2024-03-01 00:00:00 CAFIAC FIX

2024-03-11 00:00:00 CAFIAC FIX

2023-05-22 19:20:09 Older people are the big aerosol particle emitters https://t.co/RFBdviRWOS @PNASNews https://t.co/QaE2a6Wx9o

2023-05-22 15:30:50 Another example https://t.co/VueXtAFqgU

2023-05-22 15:28:45 Seeing pain the brain "The development of personalized pain biomarkers will be central to accurate diagnosis, tracking prognosis and for future therapeutic drug and device development." @NatureNeuro @PrasadShirvalka @NeurosurgUCSF https://t.co/l2RTmjRjhY https://t.co/rSzqvKvsF8

2023-05-22 15:26:44 Example https://t.co/JcyvN2AUs2

2023-05-22 15:26:43 @NatureBiotech Continuous wearable ultrasound using #AI to auto-capture body deep tissue imaging and physiology during mobility for up to 12 hours https://t.co/GVZwrLTEkr @JackLin62608901 @XugroupUCSD @JWangnano @UCSDJacobs

2023-05-22 15:09:19 "#SARSCoV2 was detected in aerosol samples up to 52 days after the initial infection." @NatureAging from aerosol monitoring of 3 Belgian nursing home outbreaks https://t.co/Y8xcfk7a1P #COVIDisAirborne @ElsKeyaerts @johanvawe and colleagues

2023-05-22 13:24:19 Our #AI times :-) @speedbumpcomic https://t.co/YVdjg3VQy6

2023-05-22 13:07:16 A biomarker has been validated as an independent and significant risk factor for heart disease and cancer, but isn't being used clinically. Why? https://t.co/notqyijOMH https://t.co/EPtoEwNbSG

2023-05-21 20:26:11 It's time to get serious about CHIP. Step 1-what is it? https://t.co/notqyijOMH https://t.co/bFkmW9DNUo

2023-05-20 19:51:12 More on this, H/T @LawrenceYoung11 https://t.co/OxJf8Ake8B https://t.co/WOG7D135TP

2023-05-20 17:49:11 This is part of the Hospital-at-Home movement, reviewed here https://t.co/W95yJBsFGp

2023-05-20 15:51:22 #MONITORHF trial @HFA_ESC #HeartFailure2023 Presented today by Jasper Brugts, @rudolf_deboer and colleagues https://t.co/xPzNGd5ku3

2023-05-20 15:42:28 @TheLancet A randomized trial in patients with heart failure shows superiority of remote monitoring for prevention of hospitalizations and marked improvement in quality of life metrics compared with standard care https://t.co/HKtWu8VMid @escardio @rudolf_deboe https://t.co/LNGegBNC9F

2023-05-19 23:21:06 @sciencethecat @alanalda Thank you!

2023-05-19 19:00:00 CAFIAC FIX

2023-05-21 19:00:00 CAFIAC FIX

2023-04-21 00:00:01 CAFIAC FIX

2023-04-15 00:10:53 RT @pnatarajanmd: Why do hibernating bears, despite prolonged immobility, not get venous thromboembolism? In a new study, scientists prior…

2023-04-15 00:09:43 @DocJeffD That’s a key point that many people miss. Thanks

2023-04-14 22:46:33 RT @JPWeiland: According to wastewater data from https://t.co/BDwnbGcDaH, US infections are the lowest they've been in over a year. Out of…

2023-04-14 16:19:25 How #AI performance results should be reported, not the way it's done now https://t.co/6XGX0XWure @ScienceMagazine by @DrRyanBurnell and colleagues and https://t.co/pdG03N1bPt @brittanytrang @statnews https://t.co/nPZMxweEMa

2023-04-14 15:11:42 This week there have been 2 important reports that reinforce the bivalent BA.5 booster did better than expected 1. Protection vs BQ.1.1 and XBB.1.5 https://t.co/tBIutN6SVP 2. High effectiveness vs severe Covid in large cohort age 65+ https://t.co/tt54BE3WzI https://t.co/Qfhqrdqrw2

2023-04-14 15:02:11 The XBB.1.16 characterized by @SystemsVirology https://t.co/5yC2vlnp1v

2023-04-14 14:59:09 The XBB.1.16 variant, with a decided growth advantage as seen in India, is starting its overtake to become the dominant one in the United States https://t.co/jjl2AnOYb5 Clinical implications are unclear, but likely not a significant wave here. Still reason to be cautious. https://t.co/LFu2TA3J3i

2023-04-14 14:40:10 How is our gut microbiome transmitted? https://t.co/9HDLp1J2dA @cibiocm @Nature https://t.co/5wd4kJouvg by @Amira_Metwaly @nsegata @NatRevGastroHep Important implications for health and disease https://t.co/dVJmUATl0T

2023-04-13 22:42:52 "This study is one of the first to evaluate real-world effectiveness of the bivalent mRNA vaccine booster to reduce hospitalization or death due to Covid-19." 68% reduction of death https://t.co/2RjM4XpUWY

2023-04-13 22:39:25 A 72% reduction of Covid hospitalizations with the bivalent (BA.5) booster vs not boosted in people age 65+ https://t.co/5Bw8YvZwvm @TheLancetInfDis @ClalitHealth @ClalitResearch @ArbelRonen and colleagues https://t.co/9eo6ES4up3

2023-04-13 17:09:01 It's not (usually) cancer that kills

2023-04-13 16:35:21 On the multitude of ways LLM #AI like #GPT4 can impact healthcare https://t.co/Rp4cjo0RGV @Nature https://t.co/kL3oaMGUwH https://t.co/hdeVeQ34cC

2023-04-13 15:42:26 Nice graphic summary of cancer immunotherapies https://t.co/JjlghpGJdL @CellCellPress https://t.co/m1KJRjbeAi

2023-04-13 14:43:18 Our #AI times by @kaltoons https://t.co/kHTskiYrR8

2023-04-13 14:13:59 Smartphone DIY ultrasound imaging w/ #AI guidance https://t.co/4TOhpA2nXD More in-depth here https://t.co/cqHYQjCziX https://t.co/WeoiC5u1TO

2023-04-13 13:57:44 A T-cell directed vaccine against Covid, with non-spike, conserved antigens (e.g. nucleocapsid, ORF1ab), effective in experimental models for preventing disease, has gone into clinical trials https://t.co/Iahj9pTCzI https://t.co/JbQYGGjd8c @CellCellPress https://t.co/j1wJGVHLNT

2023-04-13 13:36:36 Beyond autoimmunity as a mechanism for #LongCovid, the heightened risk of autoimmune diseases "Compelling and reliable evidence that #SARSCoV2 infection is linked to a substantially increased risk of developing diverse new-onset autoimmune diseases..." https://t.co/QJx7nBcvGe https://t.co/D1qPPNONbL

2023-04-13 00:50:54 If you’re interested in how #AI will reshape healthcare in the large language model era https://t.co/49Z35U2hED

2023-04-12 23:07:50 A significant advance for #Parkinsons disease: the biomarker α-synuclein is an accurate classifier, detects very early (prodromal), and a target for Rx as determined in a large cohort with controls https://t.co/NEQUzefu0n @TheLancetNeuro https://t.co/v7IBfpkgSL

2023-04-12 21:24:06 A tour de force work in clinical genomics: >

2023-04-12 21:03:59 Full text And consistent with prior post in January on the bivalent booster's outperformance https://t.co/tR5S4BBaYb https://t.co/x6Ce1SiLrP

2023-04-12 21:01:00 The bivalent (BA.5) booster protection from Covid hospitalizations and deaths exceeded expectations vs the BQ.1.1 and XBB.1.5 variants https://t.co/0zi9RPBXC0 But VE waning seen

2023-04-12 18:04:48 National Public Radio (@NPR), a leading independent, trusted, non-profit news media organization in the United States that reaches millions of Americans every day, quits @Twitter https://t.co/QRZce75hLm

2023-04-12 17:47:53 RT @GaviSeth: Fascinating read by @EricTopol on the “major triumph” of new #RSV vaccines and why “this is the most exciting time in the his…

2023-04-12 17:45:06 @pnatarajanmd @Nature @AlexBickMDPhD @jaiswalmdphd Great body of work. Why isn't CHIP getting routinely or ever assessed in clinical practice?

2023-04-12 17:40:23 That is why this program is so damn important https://t.co/bCN1afrKt9 https://t.co/nwTGUGa4Jw

2023-04-12 16:59:38 How to prevent Covid infections in multiple experimental models that were not prevented with shots. Sterilizing immunity by a nasal vaccine https://t.co/zfpVQozLJE And a potential 2-fer against flu! https://t.co/g3z3J67TE1

2023-04-12 16:31:58 Nice thread and perspective by @Michael_D_Moor https://t.co/d88GgPuJ2z

2023-04-12 15:18:25 For free access to the @Nature paper https://t.co/Rp4cjo0jRn

2023-04-12 15:14:59 I've summarized some of the key points in a new Ground Truths https://t.co/kL3oaMGUwH

2023-04-12 15:12:42 Our @Nature paper on Foundation models (aka Large Language, Generative #AI, such as #GPT4) for medicine was just published https://t.co/z6eB0l80vY @Michael_D_Moor @pranavrajpurkar @ZahraShakerii @jure @hmkyale

2023-04-12 13:59:32 Our #AI times :-) https://t.co/ODqVL2Y2rp

2023-04-11 22:23:11 RT @CrabbBrendan: I talk about this disconnect a bit in this thread. https://t.co/a4IvkWxGTg

2023-04-11 20:05:35 "We have isolated and characterized 2 human monoclonal antibodies which exhibited neutralizing activities against all #SARSCoV2 variants tested, including BQ.1. and XBB.1.5" https://t.co/jCiQumZgG0 https://t.co/EpQAFemTuW

2023-04-11 17:36:05 As global confirmed Covid deaths reach a new low for the pandemic, excess mortality estimates are on the rise @OurWorldInData https://t.co/SJfbplurOg

2023-04-11 17:18:45 RT @chrischirp: Why or why aren't we investing in cleaner indoor air? It's a no brainer. It would be a no brainer even if covid had never h…

2023-04-11 17:03:20 Important work, nicely summarized by @VirusesImmunity's thread (above) and the paper's concluding paragraph https://t.co/tNgYfMnEIB

2023-04-11 16:24:03 @KenGursky From the @washingtonpost article. I'm quite upbeat we'll have a nasal vaccine to help block infections and this program will get us there faster https://t.co/NNisfRUX8X

2023-04-11 15:47:19 A randomized trial to individualize blood pressure medication for optimal control https://t.co/naNRVwO7IZ @JAMA_current This could be facilitated by automated, 24/7 frequent blood pressures as reviewed here https://t.co/Ek9AtGmET0 https://t.co/yTKoT7g18V

2023-04-11 14:13:58 RT @EricTopol: Should you get a multi-cancer early detection (MCED) blood test? A solid, balanced appraisal of the new "liquid biopsy" 18…

2023-04-11 12:53:46 Immune evasion of #SARSCoV2 is not only via blocking our interferons or neutralizing antibodies. As the virus evolved, suppressing the T cell response now demonstrated. https://t.co/TsZj1ovs4K

2023-04-11 12:46:40 Print version of the announcement in today's paper https://t.co/8wMqq4evM9

2023-04-11 00:39:10 @pknoepfler @AnnalsofIM @BobVolkPhD @glynelwyn Hi Paul, I wrote about it some months back (last section), not much has changed https://t.co/e7Fl0F8BDW Short term ?

2023-04-11 00:17:40 Should you get a multi-cancer early detection (MCED) blood test? A solid, balanced appraisal of the new "liquid biopsy" 18 tests that, in healthy people, can pick up microscopic cancer and w/ #AI determine site of origin https://t.co/pmfXfWLUi5 @AnnalsofIM @BobVolkPhD @glynelwyn https://t.co/zGPa0XTSkp

2023-04-10 23:49:03 This was 2 years ago. We don't need to dream anymore we can do this. https://t.co/bCN1afrKt9 https://t.co/mIgANALAar

2023-04-10 22:05:56 The background and rationale for this important initiative https://t.co/bCN1afrKt9 https://t.co/CrEaqcJkXe

2023-04-10 21:34:34 I wrote about Project Next-Gen—thankfully the United States has gotten serious about new Covid vaccines and treatments. https://t.co/bCN1afrKt9

2023-04-10 20:25:25 This is big, folks. The @WhiteHouse is supporting next generation—nasal and variant-proof Covid vaccines —and therapies with a $5 billion program https://t.co/fMxCJAzIA5 by @ddiamond Thanks to the relentless efforts of @AshishKJha46 and @WHCOVIDResponse

2023-04-10 19:53:28 How to reduce airborne disease transmission during indoor gatherings Besides mask-wearing, "ventilation and break times are critical" in prevention. "Their impact would equal or exceed that of masking and moderate isolation of infected individuals." https://t.co/ePxZTNRZhN https://t.co/wxusx7vSD9

2023-04-10 17:41:16 RT @EricTopol: A double feature Ground Truths in the past 2 days —Automated 24/7 cuff-less blood pressure wristband sensor https://t.co/Ek9…

2023-04-10 15:12:30 A randomized trial of coaching for physicians (N=40

2023-04-09 19:19:46 Chromosomal instability (CIN) "remains one of the greatest unresolved genomic challenges in cancer treatment" and may become druggable .https://t.co/n4XMLBv14I @ScienceMagazine by @Samuel_Bakhoum https://t.co/lV9LfXqDtS

2023-04-09 18:25:54 @CNakas Good to know. Thanks!

2023-04-09 18:18:39 RT @siobhannyc: “This is the most exciting time in the history of vaccines.” Great edition of this very great newsletter!

2023-04-09 17:07:05 RT @sarikaphatak: Non-invasive, cuff-less, continuous blood pressure monitoring bracelet - a holy grail of sensor &

2023-04-09 16:54:48 @BillyWcostigan She didn't have Long Covid

2023-04-09 16:44:09 After a patient saw multiple physicians and neurologists over 6 months and was assigned a diagnosis of #LongCovid, a relative entered her symptoms into #ChatGPT with the correct output. Diagnosis was confirmed by antibody testing and therapy has been initiated. https://t.co/lFfp1zZmRT

2023-04-09 00:45:14 A double feature Ground Truths in the past 2 days —Automated 24/7 cuff-less blood pressure wristband sensor https://t.co/Ek9AtGmET0 —Why the new RSV vaccines are a BFD https://t.co/MJmiy8FFUj https://t.co/yIZnHbUeBL

2023-04-08 20:32:33 @BagaiDr Thanks Sanjeev

2023-04-08 19:35:52 https://t.co/fxvud14CnX

2023-04-08 17:24:27 RT @Daltmann10: Posts Exaggerate Lab Findings About COVID-19’s Impact on Immune System https://t.co/SD3LKVmg2m via @factcheckdotorg

2023-04-08 15:59:10 A very good glossary in the new world of GPT-x #AI https://t.co/MDOFG8iBpB by @Adampasick https://t.co/PoZlAXAZjt

2023-04-08 15:50:00 The free speech of @elonmusk's Twitter, yet again https://t.co/GHlwBcjgdJ by @kateconger @RMac18 https://t.co/gvFGNRDjj9

2023-04-08 14:49:32 Yup. #AI will have a transformative impact on medicine https://t.co/jYWmstBrft by @ISBLeeHood @ISBNathanPrice https://t.co/ekyM3WQswp

2023-04-08 00:53:45 Incredible and pathetic: this is what @twitter puts out in response to my post on substack! https://t.co/5Dnyao4trN https://t.co/VCQwToDwKg

2023-04-08 00:00:58 RT @JPWeiland: I'm honored to have my work featured in @NYMag along with @EricTopol ! Yes, the US is in a decent lul, but it's imperative…

2023-04-07 21:18:49 So Twitter won't allow responses or retweets to a Substack post. "free speech" https://t.co/5Dnyao4trN

2023-04-07 21:00:48 Characterization of the growth advantage of XBB.1.16 compared with XBB, XBB.1.5, with its increased fitness that will likely account for it replacing the current variants https://t.co/5yC2vlnp1v by @SystemsVirology

2023-04-07 20:34:26 @DKThomp I just posted a new @Substackinc and @twitter won't allow responses or retweets! https://t.co/Ek9AtGmET0

2023-04-07 20:31:47 Independent replication of some reduction (~25-30%) of #LongCovid with Paxlovid treatment versus controls, among non-hospitalized, vaccinated people with acute Covid https://t.co/52pBWBYpBt @rushin311 @SarjuGanatraMD and colleagues @LaheyMedicine @LaheyHospital https://t.co/bmMuo3ZAds

2023-04-07 20:19:23 The new Ground Truths is about a continuous BP monitoring bracelet I've been testing https://t.co/Ek9AtGmET0

2023-04-07 15:11:23 Spike protein in the skull-meninges An important niche of the brain immune response as reviewed in this new @ScienceMagazine paper https://t.co/RQ7uxMWQra https://t.co/yfJwjUoiGt

2023-04-07 15:02:15 XBB subvariants are starting to crowd out XBB.1.5 in the US without notable change in clinical outcomes. XBB.1.16 is here and not shown by @CDCgov tally, likely the one to overtake in the weeks ahead https://t.co/jjl2AnOYb5 https://t.co/hdxN6pb4Sm https://t.co/YRSB3jepwW

2023-04-07 14:36:48 Nah by @sdutBreen https://t.co/qdGs3tcc5u

2023-04-07 14:18:48 For a future of everything piece, I spoke to @arianapeca2 about smartphone ultrasound image #AI selfies https://t.co/4TOhpA2nXD https://t.co/gO9Dt5HWc5

2023-04-07 05:54:56 @chrishendel @karlsteinberg @ScienceMagazine @jcouzin Exactly. Thanks

2023-04-06 22:59:29 How Covid is transmitted in households, via a prospective study and dense longitudinal testing (through Alpha variant wave) https://t.co/H9U8YVvgJl @LancetMicrobe Hands and surfaces play a role https://t.co/xxNC1Natwb

2023-04-06 22:08:45 This also relates to the very interesting report of #SARSCoV2 spike protein found in the skull-meninges-brain axis today https://t.co/N2tVLKn37A

2023-04-06 22:07:04 Our understanding of the brain and immune system has radically changed . A new, 5 review @ScienceMagazine today by @castel_giulia @Tommaso_Croese and @WeizmannScience colleagues w/ @ScienceVisuals https://t.co/RQ7uxMWQra https://t.co/k97SYiurRP

2023-04-06 21:24:43 Julia, better than R and Python, for life science? https://t.co/oZNEd7mR9e @NatureMethods by @Roesch_E @theosysbio @jgreener64 @nassarhuda @ChrisRackauckas @adamlmaclean @JuliaHubInc https://t.co/i82bgpMAEN

2023-04-06 20:26:22 I think we can do this without an algorithm https://t.co/wxD0iOZFms https://t.co/eFzq4sRNeq

2023-04-06 18:23:16 Ugh. Honey, I (new Alzheimer drugs) shrunk the brain https://t.co/2LpM15zPRz @ScienceMagazine @jcouzin https://t.co/yd6Qkrk65P

2023-04-06 17:34:27 The potential and a mechanism for diet and probiotics to rev up immunotherapy vs cancer and improve clinical outcomes https://t.co/zvyKyaFDYr @CellCellPress @MeiselLab @MackJBender @AlexCMcPherson https://t.co/crLnjgJkPM

2023-04-06 17:19:58 Spike protein in post-mortem human brain https://t.co/HFlOfy7krf

2023-04-06 16:33:33 A randomized trial of time-restricted eating (w/ intermittent fasting, iTRE) vs calorie restriction or standard care in people at risk for diabetes #T2DM https://t.co/BuyDdOYdJb iTRE best for glucose metabolism @NatureMedicine https://t.co/AoHi0Z0b0K

2023-04-06 15:52:06 Centenarians have a youth-pattern gut microbiome signature https://t.co/nkkSAMdxcV @NatureAging https://t.co/4N39oyrVAo

2023-04-06 15:04:33 The death rate for Covid still markedly exceeds that of flu for hospitalized patients with either virus (6% vs 3.75%), as seen among people age 65+, and higher among unvaccinated, in the @DeptVetAffairs dataset https://t.co/DUNjRkxjp5 https://t.co/CTi7bNKQ6Q

2023-04-06 14:15:54 as shown here https://t.co/lfxHqsy5Wf

2023-04-06 14:00:31 https://t.co/2svEVytLG3

2023-04-06 14:00:30 Important new report on #LongCovid and the brain demonstrating persistence of the virus spike protein, throughout the body and particularly the skull-meninges axis, both in humans and the mouse model https://t.co/tcOywXMafL by @erturklab @zhouyi_rong @HongchengM @Sakethkapoor https://t.co/JqISpqaiLi

2023-04-05 21:22:13 These are major triumphs 66 years later after RSV was 1st reported. It is the/a leading cause of pneumonia in young children and older adults. Accompanying editorial by @ruth_karron https://t.co/q7EVzpTnls See importance of prefusion spike stabilization in Feb 15 thread above https://t.co/7DwqRyUvbs

2023-04-05 21:14:31 "But now with these LLMs like #ChatGPT, you see patients going to and asking questions that they’ve wanted to ask their doctors — because...you forget things when you go to the doctor, perhaps because you’re stressed, and because, unfortunately, doctors don’t have that much time"

2023-04-05 21:09:14 "Having #AI as an assistant to the doctor is going to play to the strength of the doctor as an intellectual, compassionate provider of care....I fully anticipate is going to happen in the next year, year and a half"—@zakkohane https://t.co/wp3YpI0BoA

2023-04-05 21:02:00 New @NEJM today: 2 new randomized trials showing high efficacy and safety for an RSV vaccine in pregnancy (against infant illness) and adults 60+ years of age https://t.co/fAs6UFuEPr https://t.co/F3JJwt8SMO https://t.co/VRNDvqIciH https://t.co/K7TkpcvbDI

2023-04-05 20:36:09 RT @stephaniemlee: Scoop: A peer-reviewed study claimed that as many as 278,000 people have died from COVID vaccines. It went viral in anti…

2023-04-05 19:52:32 RT @SouaidTarek: 1/ Ever wondered how the 4th industrial revolution (#AI, robotics, and big data) is reshaping healthcare? Let's dive i…

2023-04-05 15:40:49 Air pollution and diminished Covid vaccine response https://t.co/7q4Z6cjINF and lung cancer in non-smokers https://t.co/Fb1aMnJyys @Nature https://t.co/w6E30TVFMr

2023-04-05 15:20:37 "#AI-guided assessment of cardiac function in echocardiography was... superior to the initial assessment by the sonographer." Saved time for both sonographers and cardiologists https://t.co/6OBOdfIrxh @Nature @David_Ouyang @bryandhe @james_y_zou @CedarsSinai @StanfordDBDS https://t.co/w1iFM92axJ

2023-04-05 01:27:18 Mask studies, before &

2023-04-04 21:06:11 @inducekarmaaa Maybe you should read the thread before posting......

2023-04-04 19:16:55 Twitter's steady deterioration. As recently documented here by @faizsays and @jeremybmerrill https://t.co/G6835BLBrL It extends well beyond its "For You" timeline https://t.co/ue7YB0VD42

2023-04-04 16:01:35 #GPT4 and #ChatGPT comes to radiology https://t.co/736FIz1rBN "GPT-4 successfully transformed all free-text reports into valid JSON files without error (170/170), which could then be read automatically." https://t.co/JLbBlKXGyi Tested for breast cancer screening advice

2023-04-04 15:44:04 I hadn't heard "King Kong" applied to the new obesity drugs https://t.co/OHFt8X6FMY by @Loftus I reviewed them here https://t.co/SMZO20WGRs https://t.co/2B4BuVk21u

2023-04-04 15:24:02 The weekly US Covid death rate hit a low for the pandemic https://t.co/hdxN6pb4Sm But so many of the ~230 deaths per day are preventable https://t.co/LiUWY65XRC

2023-04-04 14:46:10 In the works: multiple shots on goal for preventing Alzheimer's disease https://t.co/S6uOvC3WAL Feature @Nature by @alison_c_abbott https://t.co/z8FD0ifgcp

2023-04-04 02:06:00 RT @CrabbBrendan: The science keeps moving... Well worth keeping infection/reinfection rates down with existing vax, breathing clean indo…

2023-04-04 00:56:39 It should not be paywalled. Here's the crux of the text https://t.co/NdddNA3EZM

2023-04-04 00:42:48 Finally. @US_FDA approval to make available free 2nd bivalent booster for age 65+ and immunocompromised https://t.co/2D22cuxt9W by @lauriemcginley2 and @bylenasun

2023-04-03 21:55:30 Before we were left with no effective monoclonal antibodies to #SARSCoV2, some real world evidence suggests they were effective in reducing death by 86%, hospitalization by 26%, including immunocompromised people https://t.co/NHDSOz1Xe6 @AnnalsofIM @marroquinoc @UPMC https://t.co/gi0hNBvLns

2023-04-03 17:54:30 A review of nanomedicines for heart and vascular indications "Nowhere is this more evident, important and impactful than in cardiovascular medicine." https://t.co/mcoWBDok3c @NatureCVR https://t.co/ZQCMAgGJ20

2023-04-03 16:07:53 It's very expensive to train #AI large language models, quantified, making this unlikely to be achievable in academic institutions https://t.co/lDNrKtscgV https://t.co/5coO3yR4up

2023-04-03 15:49:14 @NatMachIntell https://t.co/HHfMoOrX4O

2023-04-03 15:45:23 A blueprint for multimodal graph #AI learning https://t.co/zATisTNBZk outstanding perspective piece by @YEktefaie @marinkazitnik @GDasoulas @ayushnoori @MahaFarhat @harvard_data @HarvardDBMI https://t.co/Dr1SkcDJLA

2023-04-03 15:16:13 Important work by @NouaillesLab and colleagues @ewyler @ChariteBerlin @FU_Berlin entering clinical trials https://t.co/uxglb1PmJQ

2023-04-03 15:16:12 A nasal vaccine induced superior mucosal and systemic immunity vs #SARSCoV2 variants compared with mRNA (Pfizer) and adenovirus-vector vaccines by serology, histopathology, scRNA -seq in hamsters @NatureMicrobiol https://t.co/N2DVNyUPIA https://t.co/YjsDRUy7aj

2023-04-01 06:11:42 @OpenMedFuture @Twitter @verified @SubstackInc Better business model? https://t.co/G6835BLBrL

2023-04-01 06:06:50 @WorkmanLesley Many thanks

2023-04-01 05:23:14 I'm with @DanRather and so many others who I respect, follow and trust on this https://t.co/x4WaZP1dOY

2023-04-01 04:06:43 @LMetermaid @Twitter @verified @SubstackInc https://t.co/b6jcsh9ZJK

2023-04-01 03:55:55 @Arriadna @Twitter @verified @SubstackInc Thanks. Exactly what’s happening

2023-04-01 03:35:31 Wouldn't pay @twitter for a blue After >

2023-04-01 02:36:29 RT @loscharlos: Spoke with @Nature about how it’s incredibly perplexing for NIH to be prioritizing #LongCovid clinical trials that will add…

2023-04-01 00:30:19 Two more new publications and on #AI for surgery by this outstanding team https://t.co/TK7Rrsdjrq

2023-03-31 20:20:13 RT @MarkELindsay: Pleasure to write this editorial with @EricTopol describing our present and future work applying #AI to genetic and clini…

2023-03-31 20:10:21 Potential concern raised by these variants on T cell immunity https://t.co/bfuUvZKyZb

2023-03-31 20:10:20 Continuation of USA=XBB variants with XBB.1.9.1 gaining and XBB.1.16 (big in India) in the background showing more growth advantage https://t.co/jjl2AnOYb5 Unclear whether any clinical outcomes will be affected by transition from XBB.1.5 to these recombinants w/ added mutations https://t.co/yTXUHM5Sj1

2023-03-31 19:46:08 RT @jburnmurdoch: The result is that the US is the only developed country where even if you strip out all Covid deaths, life expectancy sti…

2023-03-31 02:33:40 Dysmorphic, widened aortas are quite common

2023-03-30 23:51:31 Using #AI to predict and ultimately prevent aortic dissection Our new @TheLancet digital medicine essay https://t.co/zTPk4MtrD6 @MarkELindsay @patrick_ellinor @jpirruccello https://t.co/oqjyHRUTyr

2023-03-30 19:50:42 RT @TCLawry: If you want to move beyond the hype surrounding GPTx and its application to medicine, read this assessment by @EricTopol of a…

2023-03-30 19:30:06 The connection between obesity and autoimmunity https://t.co/qJl1XbzCad @ScienceMagazine w/ @ScienceVisuals https://t.co/7LmkotJVLg

2023-03-30 18:33:00 Using #AI to enhance the performance of surgeons https://t.co/qsKA2wMQdQ @natBME @AjhungMD @DaniKiyasseh @Runzhuo_Ma @haqueward @ddonoho @AnimaAnandkumar https://t.co/US3c6GrZdU

2023-03-30 18:20:26 RT @davidrliu: Today we report in @ScienceMagazine a one-time base editing treatment for Spinal Muscular Atrophy (SMA), the leading genetic…

2023-03-30 01:40:14 Here is one example from the book where #GPT4 is coaching the doctor to be more sensitive and empathetic https://t.co/TFFzjH06jC https://t.co/nz9UeBols6

2023-03-29 23:41:04 @AndrewYNg Thanks for this important thread, Andrew

2023-03-29 21:38:17 @ATabarrok Intentional. Thanks for your close read, Alex

2023-03-29 21:28:54 This is the #AI in medicine review article with historical context and a short section on chatbots https://t.co/grbBThRROQ

2023-03-29 21:08:49 Link for the #GPT4 paper https://t.co/bHgUgFzPsf

2023-03-29 21:05:00 New @NEJM Marked reassurance that the bivalent BA.5 vaccine is not associated with increased clotting events https://t.co/LurDno0QBD "We previously found no increase in the incidence of stroke, acute MI, or pulmonary embolism after the administration of the monovalent vaccine." https://t.co/u44yk7aVoy

2023-03-29 21:01:00 The @NEJM is getting serious about covering #AI in medicine with a new series and journal. A #GPT4 preview, review and editorial today This important advance is covered in-depth in a new book https://t.co/hGyrJt4yt7 https://t.co/NeOeOGtxsb

2023-03-29 18:51:38 Discovery of a "molecular syringe": new way to deliver functional proteins into human cells with very high efficiency that exploits #AlphaFold, #AI, and nature https://t.co/yvlBaXBCZO @heidiledford https://t.co/ImfwywvNJ0 @Nature @zhangf and colleagues

2023-03-29 17:32:23 Is this really worth full page ads ⁦@nytimes⁩ and ⁦@washingtonpost⁩ today? https://t.co/QAeHINKBRc

2023-03-29 17:01:54 Our #AI times :-) ⁦@speedbumpcomic⁩ https://t.co/mCmCcqd2jz

2023-03-29 02:16:38 RT @AI_4_Healthcare: Leave it to @EricTopol to whet my appetite for the next big #AIinHealthcare book. Can't wait to read it. Hey @peteratm…

2023-03-28 21:59:19 "I struggle to understand why the healthcare systems of the world’s richest countries are not yet using all the knowledge that science has provided to bring more help to.. millions of others living with pain." https://t.co/STqC1VB2qh by @lucy_os @Nature https://t.co/YynX6ATaLX

2023-03-28 21:43:51 Wild animals suppress misinformation but we can't https://t.co/UWvTtNV58j @PNASNews https://t.co/sJm6mVaBnL

2023-03-28 21:25:23 #ChatGPT is so old Here's what GPT-4 (and beyond) can do for healthcare https://t.co/hGyrJt56iF

2023-03-28 21:20:16 For uninitiated healthcare personnel, #AI can guide obtaining high quality ultrasound images in patients with trauma https://t.co/95o99AYh3v @JAMANetworkOpen https://t.co/xWRu9RRGAH

2023-03-28 20:06:24 RT @LGlaucomflecken: New episode! We had a fascinating conversation with @EricTopol about how AI will affect the medical profession in p…

2023-03-28 05:46:06 RT @Ban_Kawas: @EricTopol @peteratmsr @goldbergcarey @zakkohane >

2023-03-28 02:00:58 RT @chrishendel: This was a fascinating read! The GPT-x Revolution in Medicine by @EricTopol Review of a new book with 6 months of asses…

2023-03-27 22:25:38 @dineshxr @peteratmsr @goldbergcarey @zakkohane Thanks. Fixed.

2023-03-27 22:17:43 I wrote about GPT-4 in medicine and a new outstanding book by @peteratmsr @goldbergcarey @zakkohane coming out soon https://t.co/hGyrJt56iF

2023-03-27 22:13:43 @loscharlos not --1000% thanks to all you are doing to maintain awareness and education with the latest information every single day

2023-03-27 22:11:03 And this :-( https://t.co/J7FSXqKssO

2023-03-27 19:48:46 Brings this piece to mind and that we need to markedly accelerate and quadruple efforts for effective treatments. Much too little is being done. https://t.co/X4B0k6ubDm #LongCovid https://t.co/Z1R7ztmZTI https://t.co/hTh6hmDwQd

2023-03-27 17:57:02 Does regular physical exercise lead to cognitive gains across the lifespan? https://t.co/p1XWeItOJv The causal evidence from the aggregated 24 meta-analyses of randomized trials is "far from conclusive" @NatureHumBehav

2023-03-27 17:09:51 Pairs with this https://t.co/1pTi8V8QMY

2023-03-27 16:48:07 Our #AI times

2023-03-25 18:46:32 @Cacciamani_MD Thank you!

2023-03-25 18:07:45 RT @chrischirp: 9. To sum up: Long Covid is real &

2023-03-25 05:46:19 @Brad49M @DelthiaRicks @DFisman @BogochIsaac Yes. Aligns with this report. Real potential for nasal spray broad neutralizing antibodies that will be variant-proof and potentially quite durable https://t.co/Ao7LT6haaV

2023-03-25 03:34:33 @harari_yuval @tristanharris @aza Thanks for cheering us up, Yuval

2023-03-25 00:58:47 RT @LongCovidAdvoc: Yes @EricTopol calling out the Denial Dismissal Unempathetic Biopsychosocial Model of #LongCovid (This includes p…

2023-03-24 22:40:37 The key and under-appreciated dimension of time and our circadian clock in the diagnosis and treatment of cancer https://t.co/k0v8gEcYrk @TrendsCellBio @CellCellPress @ETH_en https://t.co/6NoSlHOsvP

2023-03-24 21:49:41 While there has been progress in ways to reduce the likelihood of developing #LongCovid, there's very little to show for any treatment. Small randomized trials of Paxlovid and Naltrexone are underway. Reviewed here https://t.co/NyRhyCiVJO https://t.co/BY30d03eNv

2023-03-24 20:15:21 The potential for inducing pluripotent stem cells (iPSCs) from a person to treat Parkinson's disease, congenital heart disease, and many other incurable conditions is going to be assessed in multiple clinical trials https://t.co/HiCQC1tgFz by @NidhiSubs https://t.co/ddvx3t1z5m

2023-03-24 19:44:52 USA = XBBs https://t.co/jjl2AnOYb5 XBB.1.9.1, XBB.1.5.1 showing up

2023-03-24 19:27:16 RT @chrischirp: LONG COVID : Clips from today's @IndependentSage from world leading experts. PLEASE WATCH! 1. @EricTopol We know a LOT M…

2023-03-24 03:48:04 @inducekarmaaa @NewsfromScience @ScienceMagazine @jcouzin Perhaps you haven't read many essays I've written on that very topic. There is NO minimization coming from me. 1 example https://t.co/PcV84bUOwy https://t.co/MdHYgerJvw

2023-03-24 03:33:18 RT @zalaly: Paxlovid can prevent #LongCovid The latest from our team in @JAMAInternalMed by @Biostayan @TaeyoungChoi93 @zalaly A thread…

2023-03-23 21:48:18 Thanks @substackInc! https://t.co/e1AEPEZCkP https://t.co/YllXW9J82k https://t.co/FHjr572JWR

2023-03-23 20:08:42 RT @thehowie: Four principal ways to Preventing Long Covid, with *NOVID* at the top of the list. Great piece from @EricTopol https://t.co/1…

2023-03-23 20:05:06 Summary of data supporting less #LongCovid with Omicron and its subvariants (along with more immunity built via vaccinations, infections, and their combinations) https://t.co/2Z1OxL3w2B @NewsfromScience @ScienceMagazine by @jcouzin

2023-03-23 19:37:33 A prospective, multicenter study of label-free #AI classification of brain tumors (diffuse gliomas) with 93% accuracy in <

2023-03-23 18:24:15 The #SARSCoV2 virus impact on our epigenome https://t.co/T0AxihtgJ9 @NatureMicrobiol may help "pave the way for unraveling the molecular basis of #LongCovid for its intervention" https://t.co/5SNK6JvGTf

2023-03-23 18:18:47 Links to the new @JAMAInternalMed #LongCovid papers Paxlovid https://t.co/4g04GXeYUo by @zalaly and colleagues Vaccination https://t.co/N0hZ3UPCjl

2023-03-23 16:33:09 @WBryanH @JAMAInternalMed @substack Yes, vaxxes are spike-specific for inducing antibodies in contrast to full virus exposure (including nucleocapsid protein) from infections

2023-03-23 16:24:20 Link to the post https://t.co/NyRhyCiVJO

2023-03-23 15:02:00 In @JAMAInternalMed today, 2 new papers on #LongCovid, one a systematic meta-analysis showing protection associated with vaccination--a 43% reduction, and the other with Paxlovid--a 26% reduction I wrote about this w/context in a new @Substack post https://t.co/eARtGCcZyv

2023-03-23 00:45:29 Another coffee study published today https://t.co/GAPcOWIXf2 https://t.co/VZ7g6lvRqe

2023-03-23 00:03:15 Now another large language model GPT-4 has scored >

2023-03-22 21:12:17 More today on this exciting potential outgrowth of the mRNA nanoparticle platform https://t.co/kQNleLFyqd by @kathleen_neuzil @NEJM https://t.co/Ptb0xSoGp0

2023-03-22 21:04:13 "Coffee drinkers have consistently had reduced morality in prospective cohort studies, but the mechanism for this result remains unknown"

2023-03-22 21:02:32 A randomized trial of coffee consumption showed no increased of premature atrial contractions (PACs). Secondary endpoints (hypothesis-generating): more PVCs, more physical activity, ~30 mins less sleep, no change in glucose levels https://t.co/7KDnmcpcOC @NEJM https://t.co/L9ofCbBsEr

2023-03-22 19:31:22 @dfocosi @ScienceTM Agree on all points, Daniele. There have been several bnAbs with variant-proof potential (not this one) and the concept of multi-year protection via this path is alluring, to say the least, for immunocompromised individuals

2023-03-22 18:41:37 Agree on transformative impact of #AlphaFold but that wouldn't be classified as a LLM https://t.co/7bit917Bfj

2023-03-22 18:23:48 Generative AI, LLMs: “This is going to change everything about how we do everything. I think that it represents mankind’s greatest invention to date."--@MundieCraig (a bit of hype) https://t.co/amQvYIZovL @tomfriedman Even healthcare? https://t.co/lvIjbPjZIB by @bellelin_ https://t.co/GvKsQs6vCu

2023-03-22 18:05:44 Potential of 3-year protection from Covid with a broad neutralizing antibody https://t.co/5QTuMuIc4i @ScienceTM https://t.co/nHQlkt7Dnb

2023-03-22 17:12:22 @LizSzabo He consented!

2023-03-22 16:43:51 Beethoven's DNA https://t.co/XgNfMtAOqI Identified hepatitis B and other risks for liver disease, no genetic explanation for hearing loss @CurrentBiology https://t.co/HavKGkYzp6 https://t.co/4zyLBHVpHQ

2023-03-22 05:17:53 Debunking the obesity-survival paradox for patients with heart failure https://t.co/S6gzar7Dzq emphasizing BMI as a poor metric https://t.co/yFpQe7aIEA

2023-03-21 18:26:09 This action is months overdue. The FDA has left people of advanced age and immunocompromised vulnerable https://t.co/n8BLZAPGBj by @StephArmour1 w/ @mtosterholm @BarneyGrahamMD https://t.co/KVLeWZHoKB

2023-03-20 23:07:45 @DocJeffD @AnnalsofIM Exactly. A reason for early termination of the trial and a good news that is reinforced by multiple other reports https://t.co/6iqDJ3oV1b

2023-03-20 22:28:53 @wgpWoman Thank you!

2023-03-20 22:10:28 A randomized trial of a blood thinner after severe Covid to prevent clothing events. Summary of result: "highly compatible with estimates of efficacy ranging from a 56% reduction to a 95% increase risk of apixiban compared with placebo https://t.co/SqsS7OCwKq @AnnalsofIM https://t.co/mZCcbXwKBf

2023-03-19 20:02:05 On neural innervation of cancer tissue and mind-body interactions https://t.co/9JzBpfggPY by @david_j_linden https://t.co/Rq4bu8zj43

2023-03-19 19:27:38 After the first global reduction of life expectancy since World War II, a path towards "longer and healthier lives" https://t.co/FabQ5X6RsK by @Atul_Gawande https://t.co/vCbA13L490

2023-03-19 19:11:44 A large retrospective electronic health record study of #LongCovid, with many limitations (some acknowledged) https://t.co/fitmwC7NNe w/ @zalaly @VirusesImmunity and good thread dissecting it https://t.co/wrlrn1UK9l https://t.co/5GTgdT97VD

2023-03-17 22:56:07 RT @JPWeiland: Short-term forecast for the US looking good! XBB.1.5 is receding with nothing to take it's place in the near term, with n…

2023-03-17 22:27:30 @ProperLookout Thanks!

2023-03-17 21:18:35 Why this can be considered a good sign https://t.co/qTgIEjnydz

2023-03-17 18:25:23 Thanks to all the readers and subscribers of my Ground Truths newsletter. It’s going to a new, expanded phase https://t.co/ldL5SfDzdL https://t.co/JBuy0H2Sco

2023-03-17 18:18:45 @DeepaRamani1 @ScienceMagazine Much appreciated

2023-03-17 18:16:43 @Nancy_had_enuf Thanks for noting. Yes, on Mastodon and Post. But will be using substack as my primary means of getting stuff out. https://t.co/ldL5SfDzdL

2023-03-17 17:35:19 The vital role of patients and the public in guiding #LongCovid research https://t.co/V2xLnrMLIi @NatureMedicine by @AshRouten and colleagues https://t.co/6qif9SHjUB

2023-03-17 17:18:06 All remains quiet on the new variant front https://t.co/jjl2AnOYb5 https://t.co/uw5AQ1ftNY

2023-03-17 04:38:54 RT @TCLawry: If you want to understand where GPT and Large Language Models are taking us in health and medicine, this is the piece to read.…

2023-03-16 22:10:48 @FurnessColin Thanks for your input. To quote the report "the majority of recovered COVID-19 patients had normal olfactory function based on three-year follow-up." I didn't write anything about brain function or tissue

2023-03-16 20:48:05 Loss of smell after Covid: by 3-years (the longest follow-up study to date) >

2023-03-16 20:09:40 The ceramide story and how it may add to cholesterol for gauging risk and intervening for heart disease https://t.co/gFlZfPaWeN @ScienceMagazine https://t.co/MvX8eLmOLA

2023-03-16 18:37:23 Why are so many young people getting colon cancer? https://t.co/fcADufmq22 @ScienceMagazine w/ @ScienceVisuals by @GiannakisLab @KimmieNgMD @DFarberYoungCRC @DanaFarber https://t.co/wtS8RnXzeQ

2023-03-16 18:25:47 One of the most important advances for #AI in life science has been #AlphaFold. The prediction of proteins from amino acid sequences at atomic level has a new large language model, ESM-2, from @Meta https://t.co/Hs4H8wW4eS @ScienceMagazine https://t.co/m9RXmWviu7

2023-03-15 20:54:37 Not everyday a large language model scores 85.4% on the US medical licensing exam (USMLE) Implications https://t.co/aOWx7kAw4G https://t.co/0Ehb9BMnPT

2023-03-15 18:24:42 @ScienceTM Distinct and longer term immune protection induced by Prior Covid + vaccination (hybrid immunity) https://t.co/swk5Mz0ove @CIRI_Lyon @CIRI_Bcell_lab https://t.co/IcApu7L3Vm

2023-03-15 16:41:13 An important conversation with ⁦@HeartBobH⁩ about faculty, freedom of speech, the role of academic Iinstitutions and the Covid pandemic. With ⁦@cuttingforstone⁩ +transcript ⁦@Medscape⁩ https://t.co/XevAfk4npk

2023-03-15 16:16:18 RT @sheencr: Today is #LongCovidAwarenessDay LongCovid is a condition comprising often severe symptoms that can affect many different org…

2023-03-15 02:53:44 Nothing to see here for the numbified https://t.co/OYKQV32gvz https://t.co/sX20RvgITN

2023-03-15 00:06:12 @MatisseMs @ScrippsRTI @scrippsresearch Thank you!

2023-03-14 23:23:58 A thoughtful editorial on #ChatGPT in healthcare by the editors @NatureMedicine https://t.co/thDj3UteMy There's a lot going on today with release of GPT-4, success of Med-PaLM 2 on USMLE. Put in context here https://t.co/aOWx7kAw4G https://t.co/31tiv9dWiV

2023-03-14 21:11:17 RT @ScrippsDTC: In this 2009 @TEDTalks, @EricTopol highlights several of the most important wireless devices in medicine's future. Today,…

2023-03-14 20:43:58 Today @GoogleAI's Med-PaLM 2, was just reported to score 85% of the US Medical Licensing Exam, up from 67% a few months ago https://t.co/W1Sz2CMI3C Generative #AI is going to rock medicine I just wrote about it https://t.co/aOWx7kAw4G

2023-03-14 19:50:16 RT @fammedfeisty: A really important read! Especially the part near the end about the potential for AI and LLMs to greatly reduce the admin…

2023-03-14 19:49:10 @j_corey02 https://t.co/DyGfAylUO6 It originally stated, incorrectly, that Eric Topol had declared the Covid pandemic “to be over”. In fact, while Dr Topol stated there are multiple indicators that we are entering an endemic phase of the pandemic, he does not believe the pandemic to be over

2023-03-14 17:10:24 The remarkable story of @DrFejzo's perseverance to find the biologic basis for a condition she suffered from and to help establish leadership and advocacy for it @HGMoms https://t.co/bBmEm3pueX by @scienceofmom

2023-03-14 04:48:47 RT @xkcd: Lymphocytes https://t.co/yTkMCQayZv https://t.co/2AeyEu6dFa

2023-03-14 04:31:12 @tmprowell Thanks Tatiana!

2023-03-14 01:24:15 On the mission of communicating science and medical information to the public. A newsletter about this Ground Truths newsletter and an announcement about where it's headed. All proceeds to be donated to @ScrippsRTI @scrippsresearch https://t.co/ldL5SfDzdL

2023-03-13 23:48:00 @annbmcguire123 Thanks! And @dr_kkjetelina is a gem

2023-03-13 23:29:38 @LLColorMeBlue Much appreciated!

2023-03-13 23:10:00 AI isn't "superhuman intelligence" but it's interesting that humans can up their game by learning from it https://t.co/6J619boqDu @PNASNews @jinkimsci @basvanopheusden @cocosci_lab https://t.co/M5PaDcUwqF

2023-03-13 22:59:19 A new and very good review on the emerging impact of #AI for cancer diagnosis, prognosis and treatment https://t.co/0o2Fyn2btP @CellCellPress @KyleWSwanson @ericwu93 @AshAlizadeh @james_y_zou @StanfordMed @StanfordEng https://t.co/Z5fweUWZpP

2023-03-13 21:43:24 RT @SubstackInc: "Unfortunately the toxicity of twitter has progressively gotten worse, while at the same time the ability to reach followe…

2023-03-13 20:12:07 A new post about the Ground Truths newsletter and where it's headed https://t.co/ldL5SfDzdL https://t.co/ixSk1fbtIq

2023-03-13 15:22:58 Graphic derived from this @NEJM report https://t.co/AJHTK3HesC https://t.co/f0XXHcYHvK

2023-03-13 15:05:34 Two data-driven tips to optimize vaccine immune response 1. Sufficient Sleep https://t.co/pelUhPzfOi @CurrentBiology 2. Same arm https://t.co/fqBXV8HQtq https://t.co/SPhwRrNV6j

2023-03-13 14:29:08 35% of hospital admissions with medical errors/ adverse events, according to an 11-hospital Massachusetts study. Some are being addressed with #AI tools https://t.co/IOSULOeWit by @LauraALandro https://t.co/OymOwpZdbu

2023-03-13 14:14:41 Better, but ~400 Covid deaths per day is unacceptably high, given so many are preventable https://t.co/ShoeHVejq0 https://t.co/hRwfdwTAxM https://t.co/CX1JkcOpPA

2023-03-13 03:55:02 @AlisaValdesRod1 @ewencallaway Agree. Thanks

2023-03-12 22:32:36 @DrMaireadDB @j_corey02 @AlanEnglish9 @Independent_ie @PatKennyNT @NewstalkFM Thanks. I notified @PatKennyNT @NewstalkFM as well

2023-03-12 22:07:32 RT @zalaly: @EricTopol @ScienceMagazine @NEJM This is absolutely on point. One of my favorite quotes from an Op-Ed @EricTopol wrote in @…

2023-03-12 21:19:45 Despite an estimated 10-20% of an "Omicron-like event" in the next 2 years, as I reviewed here https://t.co/qTgIEjnydz Hard to find any major initiative to develop better Covid vaccines for broader, more durable protection &

2023-03-12 21:01:16 There are over 50 published papers that identify such candidate "universal" vaccines or potent broad neutralizing antibodies that can be used as a template for such vaccines. A sampling below https://t.co/QzLzYEGTGX

2023-03-12 20:51:56 In 2021, there were urgent calls for a universal coronavirus vaccine https://t.co/V71aBHAKlr @ScienceMagazine https://t.co/XsOwK7Pcnx @NEJM There is little to show for this, despite abundant candidates vs β-coronaviruses (#SARSCoV2 variant-proof) https://t.co/tss9IivpnA

2023-03-12 17:15:16 @j_corey02 Thanks Julia. I have written to @AlanEnglish9 demanding a correction about this misinformation @Independent_ie

2023-03-11 22:24:27 It's complicated. High levels of autoantibodies have been demonstrated in some people with #LongCovid. https://t.co/NwXVISGlNd by @VirusesImmunity @PutrinoLab https://t.co/n1hxFYd4Fk by @LabHeath But some of these antibodies appear to be protective https://t.co/XlgMCwvaWd https://t.co/RvwrsnXAVg

2023-03-11 20:08:08 RT @EricTopol: My conversation this week with Prof @linseymarr, a civil engineer and leading authority on air quality, viruses, and the imp…

2023-03-11 19:36:55 3+ years in, it's sad and notable that so much work has to go in to providing the evidence (for a respiratory virus) they work. https://t.co/j9qf2ul7rA https://t.co/zEZswCHp4g https://t.co/8wFaqlj7iS

2023-03-11 15:58:24 @BiffAndFinn @Mirella_PhD @brownecfm Dr. Mirella has made a repeated false accusation that I deleted a tweet--which I did not. And thank you for explaining the lack of need for "damage control," another bogus assertion she has made.

2023-03-11 00:59:42 There's a lot of confusion about what a Covid endemic phase means. I think this short essay by @ArisKatzourakis @Nature is the best description I've seen https://t.co/J16ZGW86lu "a disease can be endemic and both widespread and deadly" https://t.co/5saXi5Q9z7 https://t.co/e2MPzrrSPH

2023-03-11 00:24:01 RT @brownecfm: 1. This is a must-read from Irish journalist, Tess Finch-Lees, dissecting the recent declaration from Professor Luke O'Neill…

2023-03-10 20:43:41 Yet another pan-sarbecovirus (#SARSCoV2 variant-proof) vaccine candidate, this one with effective neutralization vs the BQ.1.1 and XBB variants in non-human primates https://t.co/ftkVFKAYP5 @PNASNews Bu none of these have progressed to clinical trials https://t.co/YratTfR9fU

2023-03-10 17:23:48 More on this, including declaration from @cochranecollab director that their review interpretation was "inaccurate and misleading" https://t.co/eRAbEAIq6C @nytopinion by @zeynep

2023-03-10 15:55:01 The pandemic at 3 years https://t.co/rvOR5COfai by @CarlaKJohnson @AP

2023-03-10 15:37:37 Unchanged US status for #SARSCoV2 genomics with XBB.1.5 accounting for 90% of new cases, no new variants showing growth advantage https://t.co/jjl2AnOqlx I reviewed implications here: https://t.co/qTgIEjn0o1 https://t.co/PST3C7wr9l

2023-03-10 13:48:20 @MichaelColey @MichaelSFuhrer That's correct. I did not say/write "the pandemic is over"but that it appears we've entered an endemic phase (think wavelets rather than major waves). And i reviewed the current high baseline of adverse outcomes and risk of a new major variant family https://t.co/qTgIEjnydz

2023-03-10 03:18:49 @JusDayDa @Twitter That’s what I heard now from hundreds of people who follow me

2023-03-10 03:11:34 This one and most of my @twitter posts are being suppressed from being seen by followers. Whether it’s attributable to intent or default is unclear. I’ve been on this platform for 13.5 years and the ability to share information is now significantly impaired

2023-03-10 00:03:43 3 years in, the status of #LongCovid Editorial @TheLancet "Progress has been excruciatingly slow due to lack of attention and resources" https://t.co/qdQ9nF2Uon https://t.co/fxauyKYAAr

2023-03-09 23:26:40 @Sara_Sawyer_ @ScienceMagazine @ScienceVisuals @CJayWarren That kicker was powerful! Great and much needed piece

2023-03-09 22:18:22 @covid19_alex Many thanks

2023-03-09 21:22:27 @EcoSexuality Yes

2023-03-09 21:15:48 On Pandemic preparedness "Given the profound consequences of virus epidemics and pandemics, and the highly flammable tinder of 8 billion people crowded onto the planet" @ScienceMagazine w/ @ScienceVisuals https://t.co/gZRFmIr0mQ by @CJayWarren @Sara_Sawyer_ https://t.co/UF8gm5VGjm

2023-03-09 20:55:02 Beyond a month post-Covid, there's a significantly elevated risk of clots, including heart attacks and strokes that has been established by multiple studies, with reduced risk among those vaccinated https://t.co/6iqDJ3oV1b https://t.co/7bXyGZiugc

2023-03-09 20:46:26 A prospective study implicating the gut microbiome and its interconnected immune response for hospital-acquired infections https://t.co/MB82FjpscM @NatureMedicine https://t.co/UzrLLZmX1k

2023-03-09 19:46:36 Update: People age 65+ are now eligible to participate https://t.co/2FHe53TKeI

2023-03-09 16:38:20 How Covid infection induces DNA damage https://t.co/I8FKt5mreK @NatureCellBio https://t.co/qAHpRffdEv

2023-03-09 16:21:29 Current treatment of blood pressure, the most common chronic medical condition, is hit or miss, with multiple drug classes and frequent lack of adequate control. What if relevant gene variants were screened? https://t.co/ohpGLuHpkN @ScienceTM https://t.co/JxDDhL04Tj

2023-03-09 16:04:27 The effects of radiation therapy Bad: Heart

2023-03-09 15:47:56 piece is by @adampiore (not adampio)

2023-03-09 15:35:09 Looks familiar https://t.co/5XBqDVmKw7 @adampio @Newsweek (and the latter isn't ready, or even close) https://t.co/nDatHpTM9z

2023-03-09 01:24:29 Will we get "Omicronized" again? https://t.co/qTgIEjnydz https://t.co/Bera1D7BEc

2023-03-09 00:49:49 Alrighty then https://t.co/iZO9avfbS2 @Uroweb #EAU23

2023-03-09 00:38:53 RT @ahandvanish: This is so exciting (not as a brag!), but because it concretely shows huge increased interest in #LongCovid, including by…

2023-03-08 23:59:01 A new systematic review of the Covid pandemic's impact on mental heath provides some reassurance from an aggregate of 137 unique reports https://t.co/6Ir0pMPB0g @bmj_latest https://t.co/NwBlwqeUH6

2023-03-08 19:22:54 The impact of pandemic school disruption (cohort, grades 7-9, in Germany), with the intelligence test gap in results persisting out 16 months https://t.co/yhfbrZZp51 https://t.co/pR9Sbp1PuP

2023-03-08 18:52:56 Our #LongCovid review @NatureRevMicro has surpassed 10,000 @altmetric and 670K downloads @ahandvanish @LisaAMcCorkell @julialmv https://t.co/EgO7gtFvoe https://t.co/IJukoucvgE

2023-03-08 17:12:08 Along similar lines https://t.co/igjwQB4miX @TheAtlantic by @jdkstern13 "Either ChatGPT will completely reshape our world or it’s a glorified toaster.... the rest of us sit quietly somewhere in the middle, trying to make sense of this strange new world."

2023-03-08 17:07:47 Discovery of specialized neurons in the upper airway that, when removed, disrupted sickness from a respiratory virus, similar to the effect of ibuprofen or aspirin https://t.co/RGpFboFRbY @Nature @justsaysinmice @HHMINEWS https://t.co/NmRi1e8rN5 https://t.co/dP3nF9uS0i

2023-03-08 16:15:12 A succinct summary of the findings https://t.co/80zIGxMXYt by @PamBelluck https://t.co/RXLEimEzD7

2023-03-08 15:56:46 @Mike_Honey_ Here is the graph from my post. XBB.1.5 was not dominant in the US in January

2023-03-08 15:39:04 @WomenInTheBurbs Both

2023-03-08 15:24:13 The first randomized trial to show that some #LongCovid can be prevented, and other Covid updates https://t.co/qTgIEjnydz https://t.co/5kH20Tpdgb

2023-03-08 15:13:53 @thehowie Thanks Howie!

2023-03-08 14:54:34 The —is bigger better ?— for LLM #AI When #ChatGPT and large language models get exponentially bigger (such as GPT-4 at 100 trillion parameters), will they perform better? An outstanding @nature feature https://t.co/efnazvOKBi by @anilananth https://t.co/TJMx1blJM4

2023-03-08 06:15:23 @Mia__Kennedy Thank you!

2023-03-08 03:20:47 Some positive news on Covid https://t.co/qTgIEjnydz

2023-03-07 20:01:20 A nasally administered monoclonal antibody in patients with mild-to-moderate Covid for favorably modulating the hyperactive T cell immune response https://t.co/ZdkvYN74Ta @PNASNews https://t.co/IFoLSgsK53

2023-03-07 18:58:08 Indoor air quality: We're not paying attention to it or doing anything substantive about improving it. It's long overdue to get serious and all over it. a new @Nature feature https://t.co/k2LB6MkYN2 by @dyanilewis https://t.co/17vy1yURSg

2023-03-07 18:12:27 A very good thread by @zalaly on this new paper https://t.co/yE0uAE2gfF

2023-03-07 17:25:27 RT @EckerleIsabella: All true at the same time: 1) #SARSCoV2 is entering an endemic phase, new variants not causing massive infection waves…

2023-03-07 16:55:39 Why #LongCovid can affect virtually every organ system in the body? Where there is high level of ACE2 expression, the cellular entry receptor or #SARSCoV2 Connecting the dots https://t.co/P0ilk3fj9s https://t.co/EgO7gtFvoe https://t.co/z3d7SCi0xz

2023-03-07 16:39:36 @DKMedJournalist That's not the correct interpretation. The 95%CI are overlapping (below age 45 and above) and there is not a treatment by age subgroup interaction.

2023-03-07 16:06:20 Here's a good summary graphic and highlighted abstract https://t.co/NWKZJrOKIW

2023-03-07 15:58:55 The gastrointestinal impact of #LongCovid https://t.co/2lk7cJ0qsR by @zalaly and colleagues Just published @NatureComms Broad risk of GI adverse outcomes after 30 days, worse with severity of Covid, but clearcut increased predisposition even in those without hospitalization https://t.co/W7aneWVcK2

2023-03-07 15:45:09 https://t.co/SgFazpBINK

2023-03-07 15:30:39 Two very good articles on Postural Orthostatic Tachycardia Syndrome (POTS) #LongCovid https://t.co/KeTfzQKxde @PostHealthSci by @AmandaMoMorris https://t.co/m8CJHs6OM2 @bmj_latest by @trishgreenhalgh @AnaBelenEspino2 https://t.co/JQu8MXEyEm

2023-03-07 15:21:22 @Bob_Wachter Given the lack of side effects and cost for a 2 week course, I think these data support use of metformin now. We do need more studies (for a solid replication), factorial design w/ Paxlovid. There are no subgroup treatment interactions so unclear how to partition its use

2023-03-07 14:53:55 @Rob_Messinger Thank you!

2023-03-07 14:38:41 Front page @latimes AT least 95 passages of plagiarism in a #1 @Amazon book (subtitled "Nature's Lessons for a Long and Happy Life") https://t.co/6JVSLNiQFB https://t.co/btGUjhqH44

2023-03-07 01:59:58 For a total takedown of the @cochranecollab report See @tomaspueyo https://t.co/0dp9FSwQ3X For the full body of evidence on masks See @trishgreenhalgh https://t.co/h0pUsWeYeb

2023-03-06 23:52:31 That's right. https://t.co/DRX2Aq5Nax

2023-03-06 23:40:35 @CDCgov_parody @BramanteCarolyn I do.

2023-03-06 23:06:33 Genetic conditions involving impaired Type 1 Interferon response predispose to severe COVID pneumonia (previously thought to only promote susceptibility to bacterial infections) https://t.co/jF8KENVYYf @JExpMed https://t.co/qU4wF7GmNq

2023-03-06 19:16:32 Dose of metformin: 1 pill (500 mg) day 1, twice daily for 4 days, then 1 in AM, 2 in PM for 9 days Cost as low as $1. https://t.co/iSK9IYrjar

2023-03-06 18:35:17 Worked consistently across key subgroups https://t.co/8EF7hHVuhQ

2023-03-06 18:35:16 Very good news Metformin significantly helped prevent #LongCovid in a placebo-controlled randomized trial, a 42% relative reduction https://t.co/go20dm3NnN by @BramanteCarolyn and colleagues https://t.co/4uUZVINq62

2023-03-06 16:15:16 Self-directed Abs (autoantibodies) against specific chemokines (cell secreted proteins) are linked with protection from #LongCovid https://t.co/2dsP0ifxq4 @NatImmunol https://t.co/80uncmfTSp

2023-03-06 15:56:47 RT @EricTopol: We've known that Covid can predispose towards clots. But what about late effects, months after an infection? A summary of th…

2023-03-06 15:45:42 From the article https://t.co/HIOyZwJDWC

2023-03-06 15:35:45 When Medical #AI makes the headlines https://t.co/22FnYHGLJ2 @satariano @CadeMetz https://t.co/WhnUHcwjRS

2023-03-06 01:59:55 Good to see @LesleyRStahl find out what happened to Sydney @bing #ChatGPT #AI :-) https://t.co/XAjQQAn8Fh @60Minutes https://t.co/GVH3M3XfBC https://t.co/ZcvH6MYBqH

2023-03-05 16:54:58 The potential for #AI to predict flares in patients with ulcerative colitis as well or better than pathologists in a multicenter prospective study #IBD https://t.co/Lw3PYpj2hO @AGA_Gastro by @MariettaIacucci @tommasoparigi and colleagues https://t.co/l7Msqr4ewu

2023-03-05 16:39:30 Smartphone imaging to detect anemia in a vulnerable, understudied pediatric population with sensitivity 93%, specificity 90% in a small cohort https://t.co/7PfeKiHfgf @thomas_wemyss and @UCL @UnivofGh colleagues @PLOSONE https://t.co/yH7UlJQEFG

2023-03-05 16:05:18 We've known that Covid can predispose towards clots. But what about late effects, months after an infection? A summary of the evidence that has been recently updated https://t.co/6iqDJ3oV1b https://t.co/RsoxU166Yr

2023-03-05 10:00:00 CAFIAC FIX

2023-03-02 22:00:00 CAFIAC FIX

2023-02-28 02:54:05 @JN1171 @cmyeaton @dr_kkjetelina Much appreciated!

2023-02-28 02:00:12 @sharongoldman @OpenAI No! :-(

2023-02-28 00:38:19 A fun visit with 2 great epidemiologists today ⁦⁦@cmyeaton⁩ ⁦and @dr_kkjetelina⁩ giving a little tour of La Jolla cove https://t.co/0S2WqqCB5X

2023-02-28 00:04:21 This is a unique "bedside to bench to model" study (starting with affected patients to RNA-seq to experimental model) for #LongCovid and may help identify specific candidate anti-inflammatory therapies

2023-02-27 23:59:49 @sfedelelondon @NatureCVR Agree!

2023-02-27 20:35:30 Towards understanding lung scarring in people with #LongCovid and potential treatment https://t.co/mJtlBvKskn Single cell RNA-seq used to identify specific markers (e.g. IL-6, CD47) and blocking these in a humanized mouse model to decrease lung scarring @PNASNews @GerlindeWernig https://t.co/qLEK4TNdtE

2023-02-27 18:14:50 The UK has led the world in human genomics. Can it further become a science superpower? https://t.co/gvzuSDhOyU new editorial @ScienceMagazine by @jameswilsdon https://t.co/OpeqEKSiBg

2023-02-27 17:30:00 RT @tomaspueyo: Do masks work? Recently, some ppl have started claiming it's proven that they don't. Is this true? I dove into the detai…

2023-02-27 16:30:47 The persistent excess of cardiovascular deaths in the United States through the 1st 2 years of the pandemic, consistent throughout 5 Covid waves, even well after surges in cases waned https://t.co/6oXy15KX47 @NatureCVR https://t.co/InSmk1C4v4

2023-02-27 16:18:52 Summary of the multiple recent reports that support autoimmune component of atherosclerosis https://t.co/CW7cKLF9sH @NatureCVR @AndreasEdsfeldt https://t.co/xpweW6l2FS

2023-02-27 16:06:14 A new report from Canada on Covid vaccine related myocarditis in teens among 1.65 million doses (77 cases) https://t.co/yjsfU2o0TY @JAMAPediatrics "the risk of these events remains very rare" reduced further by longer interval to 2nd dose https://t.co/3KY19VeE0P

2023-02-27 15:55:37 There are already several randomized trials showing #AI chatbots can support mental health. What will be the impact of large language models? https://t.co/tUhQJq5RTB @NewYorker @DhruvKhullar https://t.co/0utc60ZSGa @NatureMedicine https://t.co/m8ZT3WQHVJ

2023-02-27 01:00:00 CAFIAC FIX

2023-02-20 17:28:20 RT @CraigJoseph: Thorough overview by @EricTopol of the history of hospital-at-home, the impact that #COVID19 had on #HaH, and what the fut…

2023-02-20 17:20:20 What if you could remove APOE4, the most important genetic risk factor for Alzheimer's disease, from the brain? They did https://t.co/KjSdgdukym @NatureAging by @GladstoneInst @justsaysinmice https://t.co/ycPrG7q219

2023-02-20 16:53:52 The @JAMA_current Editors weigh in on this new trial and the body of evidence that all points to lack of Ivermectin benefit https://t.co/3wCxBV92Sd by @KBibbinsDomingo @PreetiNMalani https://t.co/QXCXuTLFBr

2023-02-20 16:49:04 Nearly all Paxlovid drug-drug interactions can be circumvented by holding the drug or reducing its dose. A quick and practical summary @JAMAInternalMed https://t.co/Fi3Vmxn9fY

2023-02-20 16:18:37 Covid vaccination is associated with significantly reduced incidence of heart attacks and strokes during follow-up. Results of a nationwide @ncats_nih_gov study https://t.co/YsfQ3Olqj0 @JACCJournals https://t.co/H8YvtDAOyJ

2023-02-20 16:06:00 This comes after @cochranecollab review of all evidence from 11 trials + 3 recent randomized trials that were all negative. There are still >

2023-02-20 16:01:31 A new Ivermectin randomized, placebo-controlled trial at high doses for long duration fails to show any benefit, published @JAMA_current today @snaggie1 @boulware_dr and colleagues https://t.co/PyT6k8Q5Jm https://t.co/oe227wjFtF

2023-02-20 14:50:30 Our digital times :-) by Hartley Lin and @MatttDavies https://t.co/DPmjlSZoIF

2023-02-20 01:56:34 RT @NHLBlackhawks: A statement from Captain Jonathan Toews https://t.co/tn7CP57bQN

2023-02-20 01:16:52 These 2 papers were the most impressive life science achievements of the week (if not much longer). I wrote about their significance and the remarkable progress that is being made in the field of genome editing https://t.co/EGCvhT76ld

2023-02-19 22:45:26 If you want to read about some really exciting biomedical genome editing stuff https://t.co/EGCvhT76ld

2023-02-19 16:39:16 @wunschcritcare Yes, it was your brilliant book I reviewed for Nature.

2023-02-19 01:40:05 @AndrewLBeam @zakkohane @NEJM @arjunmanrai Says a lot about AI in medicine when @nejm starts a dedicated journal

2023-02-19 00:57:20 I just finished a book on the history of polio. It made me think of some interesting contrasts and similarities vs #SARSCoV2 https://t.co/wDlWaeU0zR

2023-02-18 17:12:27 Two-thirds of people age 65+ have 2 or more comorbidities. Graph of in-hospital mortality in males by age groups. A "dose response" of comorbidities on top of age. Reduced physiological reserve a key factor. "Inflammaging" discussed. https://t.co/bbTJchkrnE

2023-02-18 17:12:26 A new and astute review of comorbidities and Covid, with attention to causality and biases https://t.co/4unhpohrbX @NatureMedicine by @clarkdrussell @ICULone @kennethbaillie Their influence varies considerably by the 3 phases of illness. #LongCovid least impacted https://t.co/RXrHVUi4LM

2023-02-18 03:20:49 Just when you think you've seen it all....... https://t.co/K9Wk0Ma2Up https://t.co/mcW6gEmNNm

2023-02-17 21:21:21 When we think of the immune system, antibodies and B &

2023-02-17 18:00:37 On a related front, the definitive review on autoimmune neurologic diseases https://t.co/nXVi8Dufx0 by @darshi_r @RussellCDale and colleagues @NatRevNeurol https://t.co/Kbo0JIyiF4

2023-02-17 16:48:00 This is the best and up-to-date paper (preprint) I've seen on transformer models, what's generating the LLM buzz in #AI now https://t.co/lVeZ1BooTA by @xamat https://t.co/y4Isg5Xf8M

2023-02-17 16:04:17 XBB.1.5 now dominant is all US regions without an uptick in hospitalizations or deaths in recent weeks https://t.co/fOz9luTlTo

2023-02-17 16:04:16 Variant https://t.co/jjl2AnOYb5 Now 80% XBB.1.5 as the variant accounting for new cases, with no other variant showing gains https://t.co/81VKDjgPLO

2023-02-17 15:27:40 Ignominy. From https://t.co/JzZFPPUbwp https://t.co/8luYZ6ExJi

2023-02-17 15:03:13 When large language models make the headlines https://t.co/MrICIzKqwT "The A.I. Isn't Ready for Humans" It's worth reading @kevinroose's full 2-hour transcript for many reasons, including conversation length has now been cut by @Bing https://t.co/dtZy8MjwL0

2023-02-17 14:51:27 From the Lancet paper, the difference in health care policy for prior Covid in the US and other countries https://t.co/VUJpaTSIrB

2023-02-17 14:51:26 A year ago I wrote about the failure of the US to acknowledge the protection afforded by prior Covid https://t.co/a7bue4mMgW

2023-02-17 00:28:58 Good summary for infection-acquired immunity. The unpredictability of a Covid infection with respect to inducing severe disease and chance of developing #LongCovid https://t.co/20YnGjtgPW

2023-02-17 00:06:34 RT @WesElyMD: 1/The Haunting Brain Science of Long COVID   Here I use science to raise awareness of a growing public health nightmare hid…

2023-02-16 23:47:02 Link https://t.co/CVIyJDjF74 Graph shows comparison vs vaccination for different outcomes over time Conclusionpulls a lot of data all together Work by @IHME_UW team https://t.co/ucnoWJ0SB8

2023-02-16 23:47:01 New @TheLancet Prior Covid provided high protection vs severe disease, including Omicron BA.1 ( ~90% at 10 months post-infection), as determined by systematic review of 65 studies Protection vs reinfection was high (~78% at 10 months) until Omicron,to ~44% w/ more rapid https://t.co/DfuwoSFaW3

2023-02-16 23:12:45 Muscle biopsy in-depth assessment in people with #LongCovid w/ exercise symptoms compared with 2 control groups shows microvascular abnormalities with reduced capillaries, immune cell dysregulation, distinct gene expression signature https://t.co/ngv2vKhcLn @ChariteBerlin https://t.co/ED8OJ2zNQ2

2023-02-16 20:17:11 RT @JenSeniorNY: Can we discuss long Covid for a sec? I know: You're over it. I was too, until I got it. I'd now like to talk...etiquette.…

2023-02-16 18:09:38 Beyond an association, as established in many previous reports, evidence from Mendelian randomization that Covid can cause atrophy in specific brain regions https://t.co/NnMdcdIxuV https://t.co/IBeXhzZMFa

2023-02-16 17:05:52 A 2nd @NatureMedicine report today showing prevention of hypertrophic cardiomyopathy in mice via genome editing, reinforcing the potential of a single-dose to cure the most common genetic heart disease https://t.co/S8lqnjRyJt @davidrliu @danielreichart3 and colleagues @harvardmed https://t.co/Q4c7IJjApb

2023-02-16 16:53:39 Exciting to see genome editing of hypertrophic cardiomyopathy to correct the pathogenic variant in the humanized mouse model, laying the groundwork for a potential cure in the future https://t.co/mB4obCSMnJ @NatureMedicine @Transactivator @andreas_c_chai @UTSWNews https://t.co/6i5yvXF4jQ

2023-02-16 16:43:08 Two new prospective studies of #LongCovid --59% organ impairment at 1 year https://t.co/v1YXyYMITb -->

2023-02-16 16:29:00 A new and exceptional review of neurodegenerative diseases @CellCellPress that breaks them down to 8 hallmarks https://t.co/RymBdFZzMs https://t.co/BeWJmSbMTe

2023-02-16 15:04:21 This work to understand prefusion stabilization for RSV helped set the foundation for very rapid Covid vaccines using the 2-P (proline) substitution that stabilized the spike protein before entering cells, making it much more immunogenic.

2023-02-15 23:39:26 More background on the roll out here https://t.co/xYyfJPufCO https://t.co/ElyNtKFLih

2023-02-15 22:20:59 Why did it take so long to get these effective vaccines vs. RSV? It took structure-based design to stabilize the prefusion protein, as shown below, and nicely explained by @BarneyGrahamMD https://t.co/SDxXuKSjIs https://t.co/WuIGN5qbQB

2023-02-15 22:19:15 Another RSV vaccine much larger randomized trial (also of 1 dose) with very high efficacy in people age 60+ https://t.co/SuyAu9Dxby https://t.co/1014036Bbe

2023-02-15 22:06:56 The RSV virus was discovered in 1956 and sequenced in 1982. Only now do we have effective vaccines. Today @NEJM results for age 65+ randomized trial https://t.co/SuyAu9E516 https://t.co/HloAhDADV2

2023-02-15 19:10:01 Link @ScienceTM https://t.co/mxwylkjo6H Nice #AI work by @NimaAghaeepour and colleagues @Stanford to predict newborn outcomes @StanfordPeds @StanfordPain @StanfordOBGYN https://t.co/iCarPFNaYt

2023-02-15 19:10:00 "Using 2 cohorts w/ a total of 27,000 mothers linked to more than 32,000 neonates, and validated externally with more than 12,000 newborns, we demonstrated the ability to serially and comprehensively predict neonatal outcomes from various maternal conditions extracted from EHRs." https://t.co/KH80B8YUNe

2023-02-15 16:11:14 Delay of onset of other autoimmune diseases in small randomized, placebo-controlled trials for people at high risk Multiple sclerosis https://t.co/IyNTODFgxu Rheumatoid arthritis https://t.co/5es4J6jYEY https://t.co/qjV6NOlgCJ

2023-02-15 14:37:52 The first disease-modifying drug for autoimmune, Type 1 diabetes, to forestall its onset, represents a big first step towards preventing such conditions from ever manifesting https://t.co/YnRUdOPtrg @Nature @ElieDolgin https://t.co/H4umWEnJKV

2023-02-15 05:20:24 RT @BenLGreenberg: @EricTopol @doximity Thank you Dr. Topol! So proud of DocsGPT - Conceived and built by @doximity folks far more talente…

2023-02-15 01:46:18 It isn't taking long for #ChatGPT and large language models #AI to help physicians deal with insurance companies! @BenLGreenberg and team @doximity is all over it https://t.co/hRxorApIB8 https://t.co/9gruAX3Utz

2023-02-15 00:33:37 https://t.co/264pbVKK3C

2023-02-14 23:51:55 Succinct full text reviews the different underpinnings, the unmet needs (a lab test, distinct subtypes, validated treatments) and recognition of patient led research https://t.co/rgfhCJmz13

2023-02-14 23:43:42 Towards a deeper understanding of #LongCovid by @VirusesImmunity and @PutrinoLab https://t.co/NwXVISGlNd @TheLancetInfDis https://t.co/sYgUQapfEm

2023-02-14 20:13:58 The difference in T cell response for autoimmune conditions, response to infection, and cancer. From a new review @ImmunityCP https://t.co/QYeqcBIQsP by @Dr_ImmunoMan_D @AnaAndersonlab https://t.co/nxpYzIN0CA

2023-02-14 20:00:09 The article features @UCLAHealth's #LongCovid Clinic, with a section here on POTS https://t.co/IRnQgcQFg5 https://t.co/TNLZ3Kyt37

2023-02-14 16:53:14 A new study @CedarsSinai with association of higher diabetes risk after Covid (adjusted odds ratio 1.58) and reduction with vaccination https://t.co/7poBVuKzOx @JAMANetworkOpen https://t.co/RTmz6B1zmY

2023-02-14 14:46:59 Neurologic sequelae of #LongCovid https://t.co/aceRT1teZd @sciam by @SutherlandPhD https://t.co/mmqTdhFSVe

2023-02-14 01:47:49 RT @jonirutter: Thanks @EricTopol for highlighting this important piece by @AmyDMarcus w/ @LisaAMcCorkell. Some resources to help are here…

2023-02-14 01:12:59 RT @TCLawry: A great read (as always) from Eric Topol MD on the need to pull forward the Hospital-at-Home movement. @EricTopol #HaH #hos…

2023-02-14 00:06:31 New Ontario, Canada report of Paxlovid effectiveness shows 44% reduction of hospitalizations, 51% reduction of deaths (point estimates) without being significantly affected by age (67% age 70+) or vaccination status https://t.co/b3AQq8tmax @CMAJ https://t.co/3xej0K2xIm

2023-02-13 23:55:15 Accompanying editorial https://t.co/FUguodHuql "Given that no association was found between oral antiviral treatment and viral burden rebound ... emphasizes the importance of continuing to offer antivirals to individuals with COVID-19 who are at increased risk of progression.." https://t.co/8VwcVU9XgZ

2023-02-13 23:49:22 Lack of evidence of overall Paxlovid viral or clinical rebound in a hospitalized cohort, with subgroups identified at higher or reduced risk https://t.co/lNcuVBLzAb @CarlosWongHKU @bencowling88 @gmleunghku @TheLancetInfDis https://t.co/IsPpKzAnw0

2023-02-13 22:16:54 A long held general perception is that adults with type 1 diabetes tend not to be overweight. A new @AnnalsofIM publication of a national sample challenges that view https://t.co/J9zA25dQwj @JohnsHopkinsSPH https://t.co/1Pr0vgoLJD

2023-02-13 16:18:47 Real-time, 3D tracking of the gastrointestinal tract via a wireless ingestible microdevice https://t.co/gcJ8qF1APH @NatureElectron @Caltech tested in large animal models https://t.co/M04vwrU96P

2023-02-13 15:55:39 The pandemic provided an unprecedented incentive in the US for hospital-at-home reimbursement by Medicare. Now what? https://t.co/W95yJBsFGp https://t.co/TmTbBo47YL

2023-02-12 18:22:42 The 1st survey to assess public views of polygenic testing of embryos before implantation (commercially available in the US without data to supports it use) had surprising results @ScienceMagazine this week Excellent explainer thread below, by the report's first author https://t.co/uDbhhUbgee https://t.co/Lk5VM1pdb0

2023-02-12 17:49:43 @danielalamasmd "....this staggering scientific advance has left them facing existential questions." https://t.co/tc9aVZ8rcN

2023-02-12 15:47:03 I wrote about the Hospital-at-Home movement https://t.co/W95yJBsFGp

2023-02-11 17:36:52 @AditGinde The sensitivity analyses (as commented by the editorialists) you did to understand the missingness in test date are important. Since there are innumerable critics of the day 0 imbalance, it would be great for you to lay this out in a thread https://t.co/BQy1MOca51

2023-02-11 16:08:44 Accompanying editorial https://t.co/vsJPj094Uc by @CarlosWongHKU and @gmleunghku For those brilliant critics of the day 0 effect, read the paper https://t.co/DH8U6dd7cn

2023-02-11 15:56:04 A review of 68 vaccine effectiveness studies: Preserved protection vs hospitalizations and deaths out to 6 months, substantial waning vs infections, especially Omicron

2023-02-11 15:45:50 As we're seeing w/ #LongCovid, it's essential for researchers to work closely with patients to make progress, democratizing medical science https://t.co/LmKqgH723V by @AmyDMarcus w/ @LisaAMcCorkell @patientled "We consider patients as researchers"— @jonirutter @ncats_nih_gov https://t.co/Jdd9VGPH0S

2023-02-11 15:16:52 A new #LongCovid deep assessment of the immune response confirms dysregulation, exhausted CD8+ T cells, uncoordinated humoral-cell arms https://t.co/hIIoSyajeK @GladstoneInst @UCSFMedicine Previous report https://t.co/jFbxvgWLUP @VirusesImmunity @PutrinoLab https://t.co/prZuUlBLWA

2023-02-11 01:07:42 RT @agingdoc1: When M.D. is a Machine Doctor Helping medical doctors and patients in the Foundation Model A.I. era Excellent discussion b…

2023-02-11 00:22:25 @AstroKatie @TheLancetInfDis It's very unusual for any drug to do better in the real world (via effectiveness studies) than in randomized, placebo-controlled clinical trials. Now that we've seen this broad benefit replicated multiple times, I'd say yes (made available)

2023-02-11 00:11:22 Very low rate of clinical relapse (aka rebound) "Using emergency department visits as a surrogate for clinically significant relapse ...., we observed a *lower* ED visit rate in patients treated with nirmatrelvir–ritonavir [3.9%] compared with untreated patients [4.7%]"

2023-02-11 00:06:06 A new real-world effectiveness study documents 85% reduction of deaths and 55% reduction of hospitalizations for Paxlovid, independent of vaccination status, age, variants https://t.co/9Hu7W6NPs3 @TheLancetInfDis https://t.co/D7TGUvPCYf

2023-02-10 20:43:27 @kyle_carm Community levels (below), a formula defined by the CDC website, are different from transmission https://t.co/6ZN3NXbhwW

2023-02-10 20:30:05 RT @NSpottiswoodeMD: What a delight to talk about unbiased diagnostics and amoebic brain infections with the awesome @ronwinslow at the @WS…

2023-02-10 19:40:01 Community transmission data by county is improving but still relatively high, so don't let your guard down https://t.co/WrhEyCPXkF https://t.co/InuBEkxloM

2023-02-10 19:34:49 "Metagenomics is the future of medical diagnostics. It should be the present, but not many hospitals are equipped to do it." https://t.co/bi8eExQbxX @UCSFHospitals @UCSFMedicine by @ronwinslow More here (A Culture of Cultures): https://t.co/Y8eZSBt3dQ https://t.co/LsyGgUl2d3

2023-02-10 17:57:31 RT @hholdenthorp: My column that builds on the great editorial from Shirley Malcom and @sudipsparikh about graduate student and postdoc sal…

2023-02-10 16:59:02 Some common underpinnings of #LongCovid with multisytem inflammatory syndrome in children (MISC-C) https://t.co/gdgV4JoNOL Persistent virus/remnants, dysregulated immune cell activation, multisystem involvement, autoantibodies, delayed response @ScienceMagazine by @BrodinPetter https://t.co/G0HEm5FJnl

2023-02-10 15:48:10 Outside the Northeast region during XBB.1.5's rise, there was no surge in hospitalizations, now below 30,000 nationally. Deaths have come down from ~500/day, but still alarmingly high with a substantial proportion preventable https://t.co/1gAUEnzRZQ

2023-02-10 15:37:37 All regions are XBB.1.5 dominant except the Northwest https://t.co/hl2s2kN6kT

2023-02-10 15:37:36 The XBB.1.5 variant now accounts for ~75% of new cases in the United States, with no other variant showing gains (including CH.1.1) https://t.co/jjl2AnOYb5 https://t.co/PpqPgz8atN

2023-02-09 21:06:14 Discovery of a new receptor for the #SARSCoV2 spike protein (LRRC15) that binds to the virus like molecular Velcro https://t.co/D8WbwEvjGp @PLOSBiology @Neely_Lab @LLTheResearcher @Sydney_Uni and colleagues

2023-02-09 19:27:23 Accompanying editorial pointing out the flaws in medical education https://t.co/teVQigZtT4 https://t.co/GEi7cePwQv

2023-02-09 19:14:53 When #ChatGPT performs at the passing threshold for the US medical licensing exam (USLME) https://t.co/6ct6fbOujI @PLOSDigiHealth I wrote about the implications https://t.co/2Axg5C4HtT https://t.co/XquPMjXtNu

2023-02-09 18:04:01 New @CDCMMWR reviews the data above, age 12+ https://t.co/03bkAOmvh4 https://t.co/D7QbJi15IX

2023-02-09 17:03:21 An inhaled hydrogel shield coats the airway to prevent Covid infections, yet another way to get ahead of this virus, no less other respiratory pathogens https://t.co/UhWJ61IFEi @NatureMaterials https://t.co/E9q8ZsYf8t

2023-02-09 16:48:05 Long term caloric restriction: a small effect on biologic aging, as assessed via DNA methylation markers in a randomized trial of healthy adults @NatureAging https://t.co/OBBmA3RRu3 https://t.co/M9ebUU5v1n

2023-02-09 15:51:31 RT @Dakota_150: Osterholm Update: "Episode 124: Taking Long COVID Seriously" https://t.co/rJZK3LocYA

2023-02-09 14:57:38 “The pandemic after the pandemic” Today’s ⁦@washingtonpost⁩ editorial on #LongCovid https://t.co/8gjEK16dao

2023-02-09 14:35:34 RT @EricTopol: Interferon λ, a new way to cut hospitalizations by 50% after Covid, in a randomized, placebo-controlled trial >

2023-02-09 03:03:09 It is frankly pathetic that this treatment will unlikely be available in the US, based on FDA regulatory and financial issues https://t.co/GzTIylaxam @benjmueller “I don’t know of any virus that can navigate a cell where interferon got there first”--@virusninja https://t.co/19lTWBKWUs

2023-02-09 01:23:53 It took over an hour to post this thread when Twitter was down and I almost gave up. But persisted because I think it’s quite a significant finding that broadens our potential (currently very limited) out-patient treatments

2023-02-09 00:02:15 Why are doctors so polarized about Covid treatments (HCQ, ivermectin, vaccines)? https://t.co/WaBCVuGe3Y "The preference for @FoxNews is a significant predictor of 8 outcomes (controlling for political ideology)" "Political ideology colors the evaluation of scientific evidence" https://t.co/VYECDMsvFx

2023-02-08 23:49:19 New @bmj_latest Protection for newborns/infants by maternal vaccination https://t.co/lkFaPRLiTY https://t.co/puT8gu1KwS

2023-02-08 23:00:38 And as seen here and in the new trial report, viral clearance was accelerated https://t.co/9izufULZ2I

2023-02-08 22:56:01 A single dose injected under the skin No increase in adverse events cf placebo Some key data summary points below https://t.co/YY0dYVqbfg

2023-02-08 22:56:00 Consistent across pre-specified subgroups, notably vaccinated (84%) and the unvaccinated https://t.co/Bovuyn71hq

2023-02-08 22:53:08 Consistent impact across variants, ~50% Omicron https://t.co/tc1MVhEvlO

2023-02-08 22:53:07 Interferon λ, a new way to cut hospitalizations by 50% after Covid, in a randomized, placebo-controlled trial >

2023-02-08 20:19:50 I was disappointed and surprised by the lack of mention of #LongCovid during last night's SOTU https://t.co/l5X0T8MaCU https://t.co/9dNC8iUx8b

2023-02-08 20:11:07 @_Eric_Reinhart @nytopinion @NewYorker Much appreciated, Eric. Your oped was so powerful, folding in the last few years of Covid, and deeply reinforcing the need for universal healthcare. If only we could use our collective power, as you aptly put it, to achieve the changes so desperately needed

2023-02-08 19:25:47 "Doctors can no longer be passive witnesses to these harms." Common threads for this important @nytopinion essay https://t.co/r31vUIC0GR by @_Eric_Reinhart and a piece I wrote a few years back https://t.co/XrEHsIjDQd @NewYorker https://t.co/kJPtWJpmuG

2023-02-08 17:25:20 Abnormalities of the gut microbiome in myalgic encephalomyelitis #MECFS in 2 cohorts and controls https://t.co/1mVV4RuB9W @cellhostmicrobe implications for #LongCovid too https://t.co/ZjvWWINRdX

2023-02-08 17:13:50 The search for missing heritability and a new report of ~400,000 exomes on rare/ultrarare coding variants https://t.co/39BWeJDdOG Rare variants contribute relatively little at pop level @Luke0connor @broadinstitute @danweiner92 @NadigAjay @nature https://t.co/sSPduscYRa https://t.co/SSgYVqSm74

2023-02-08 16:57:06 Agree with @JoannaStern "A big change is coming to how we get information and how we interact with our computers." https://t.co/kbsj8hVEwv @Microsoft @bingc #ChatGPT https://t.co/R6ygqmTsVo

2023-02-08 15:58:27 I discussed #AI (including LLMs) and the future of healthcare with @RobertPearlMD in the latest @FixingHCPodcast https://t.co/jaaJl0Ei6V https://t.co/Wewm3agczO

2023-02-08 15:50:02 Good news that there are no new #SARSCoV2 variants detected in China to date: @TheLancet report from ~3000 sequences (mainly BF.7 and BA5.2). Just from Beijing, thru 2022, and only a snapshot, so genomic surveillance is a work in progress https://t.co/cw7jkH5yP0 https://t.co/hLDt5UtWrh

2023-02-07 23:56:05 @JusDayDa @Microsoft @bing @CadeMetz @KYWeise Yes, I wrote about that https://t.co/2Axg5C4HtT

2023-02-07 23:17:23 Bingo for @Microsoft's new #ChatGPT powered @bing today https://t.co/LnoGJJwykQ @CadeMetz @KYWeise https://t.co/PwD9Zu0XVk

2023-02-07 22:51:38 In 2020, @ConsumerReports's investigative work showed @GoodRx was sharing medication data to tech companies w/o user permission https://t.co/qFq10QZe4o That was just the beginning->

2023-02-07 18:42:09 —I'd like to accurately sequence DNA and epigenetic modifications simultaneously —No problem, here you go —Are you kidding? —No https://t.co/cB6cBk8Xpo @NatureBiotech @Joanna_Holbrook @CEGX_news @walraj @paidicreed @ChemCambridge @Cambridge_Uni https://t.co/eO54Ecl5vp

2023-02-07 18:15:45 One end of the LLM user spectrum from @Nature link above re: @haffi67 https://t.co/TE8fQDvU0w

2023-02-07 16:59:13 The term "generative #AI" may be appropriate since #ChatGPT and LLMs are generating a helluva lot of biomedical articles https://t.co/iQJHM1lpri @stokel @Richvn @Nature https://t.co/TmGh593Sgr @KyleLam93 @LancetDigitalH https://t.co/jaLw2gp4So https://t.co/0LdLIm4S6t

2023-02-07 16:29:20 Good to see the first #AI randomized controlled trial for enhanced chest X-ray detection of lung nodules in screening >

2023-02-07 16:14:42 Direct-to-consumer drug ads: the less a drug's clinical effect, the more spent by the drug companies https://t.co/vaR3VTUyQd @JAMA_current They should be banned. And so should "further research is needed" in the conclusion. https://t.co/NXL6fh7YEL

2023-02-07 16:00:14 Spotlight on pacing for #LongCovid and #MECFS in today's @PostHealthSci by @AmandaMoMorris https://t.co/jTE6rmX7gR https://t.co/SErWfhXeep

2023-02-07 15:50:45 Reviews the biology known about IgG4, difference seen with adenovirus vector vaccines. Conclusion highlighted below https://t.co/z26fZzHryc

2023-02-07 15:35:50 A tour de force review on engineering T cells https://t.co/N9BgKZPsud by @lenghan_bioinfo @JingwenYang_ @yingjing06 @GreenLymphoLab @_meimeimei_ @MDAndersonNews that adds much to my recent review of this exciting field https://t.co/2m7WF34Pj3 https://t.co/OwZDZa1vCk

2023-02-07 15:21:44 New @SciImmunology Getting the IgG4 story right (after mRNA vaccines) https://t.co/VhgLLgb6up by @ShivPillai4 @ragoninstitute "Is it bad, good, or is IgG4 just misunderstood?" https://t.co/VnO09TOrNa https://t.co/27IkIntIc1

2023-02-07 02:47:00 RT @danielalamasmd: Imagine if your life expectancy increased by decades within your own lifespan. That’s the story for cystic fibrosis rig…

2023-02-07 02:27:25 RT @DanielCohrsMD: Great article + thread on #LongCovid and the innovative review paper below, written as a collaboration between patients…

2023-02-07 00:20:26 We had the real privilege of having ⁦@pearsekeane⁩, @ucl Prof of Artificial Medical Intelligence, as our ⁦@ScrippsRTI⁩ visiting professor today https://t.co/odHJlYLIBx

2023-02-07 00:03:57 Vitamin D may reduce the risk of developing Type 2 diabetes in people deemed pre-diabetic, combining 3 randomized, placebo-controlled trials with a modest effect https://t.co/3hYOVKUQWH @AnnalsofIM https://t.co/opbeuZcx2L

2023-02-06 23:50:47 RT @VirusesImmunity: A team member working on our #PrimeandSpike nasal spray COVID booster vaccine developed #longCOVID Long COVID is a…

2023-02-06 18:48:58 More on this report linking the APOE gene with gut microbiome-brain communication https://t.co/hkWNHdTmck @Nature @Alfonso_525 @UFNeuroscience @UFMBI https://t.co/zvNyxYhez0

2023-02-06 17:23:02 RT @WesElyMD: 25/ fin Read the most well-researched review on Long COVID to date   @ahandvanish &

2023-02-06 16:26:11 Based on nationwide screening in Iceland, the prevalence of smoldering multiple myeloma (precursor to MM, no symptoms) is higher than expected and has implications for early treatment https://t.co/ozVoIhzqj2 @NatureMedicine https://t.co/tqBRuHS2LX

2023-02-06 16:18:54 A study today purports a healthy lifestyle before Covid was associated with reduced risk of #LongCovid. That doesn't align with my experience at all—that affected individuals were remarkably health conscious and fit https://t.co/zYAnqeihUu @JAMAInternalMed https://t.co/IY1H9Fprs9

2023-02-06 16:08:56 Excess mortality among American physicians during the Covid pandemic https://t.co/fGHu44FE9R "Active physicians had lower excess mortality than nonactive physicians despite their higher risk " @JAMAInternalMed https://t.co/gMEhQ2ibRc

2023-02-05 19:21:17 RT @euanashley: A landmark study. Adverse drug outcomes significantly lower in those with pharmacogenomically-guided therapy. It is time…

2023-02-05 17:32:40 Twitter, by @stephanpastis https://t.co/ex5JhfeZGu

2023-02-05 17:24:07 Good graphic and essay for delineating the mechanism of tirzepatide (Mounjaro), a potent anti-obesity drug "that rivals the efficacy of bariatric surgery" https://t.co/A0WNI0yR62 @jclinicalinvest An important topic that I recently reviewed https://t.co/SMZO20WGRs https://t.co/ouLG6obbgI

2023-02-04 17:51:45 Rare genetic disorders in the interferon pathway and life-threatening Covid https://t.co/Mn2XZ8Bjnb @jclinicalinvest by @casanova_lab and @MAndersonUCSF https://t.co/wjZIVTzBo3

2023-02-04 17:13:08 Two studies from leading labs characterized XBB.1.5 this week. We're very fortunate that the rise of this variant to dominance in the US was not accompanied by worse outcomes https://t.co/4y0WxqCzbe @SystemsVirology https://t.co/BcoiR7MItP @yunlong_cao @TheLancetInfDis https://t.co/ztUMayhP6w

2023-02-04 16:58:31 How can #AI help improve outcomes for lung cancer, the leading cause of cancer mortality worldwide? An outstanding review https://t.co/lSRW7kUDgU @CellRepMed @ColtonLadbury @DrAryaAmini @DrRaviSalgia @cityofhope https://t.co/wS7n8XWblH

2023-02-04 16:43:35 A bit of irony "It turns out #ChatGPT is quite bad at math" https://t.co/gmR7JGo8IC @JoshZumbrun https://t.co/ImexjxNyZu

2023-02-03 23:27:55 RT @inthebubblepod: What chronic symptoms and health risks are most common in those with #LongCovid ? @EricTopol tells @ASlavitt they can r…

2023-02-03 18:07:39 Differentiate from #AI, humans spot on, by @nytdavidbrooks https://t.co/rstp6eytdS (the premise of #DeepMedicine, too) https://t.co/zwOebyJSY9

2023-02-03 16:51:47 Insightful on #ChatGPT, LLMs for science "Soon this technology will evolve to the point that it can design experiments, write and complete manuscripts, conduct peer review and support editorial decisions to accept or reject manuscripts." https://t.co/u1Gj9Ln1h3 @Nature https://t.co/ZZJzCS7aNO

2023-02-03 15:53:53 The XBB.1.5 variant now accounts for ~66% of new cases in the US, up only ~5% from last week. https://t.co/jjl2AnOYb5 CH.1.1 still low at 1.6%. No other variants gaining at an appreciable level https://t.co/PfgVZMv7xj

2023-02-03 15:46:58 My conversation with @ASlavitt on #LongCovid and getting ahead of the virus https://t.co/tuQh6rktOj @inthebubblepod Regarding our recent review https://t.co/EgO7gtFvoe @ahandvanish @LisaAMcCorkell @julialmv @NatureRevMicro

2023-02-03 14:35:32 New and succinct review of postural orthostatic tachycardia syndrome (POTS) and autonomic dysfunction post-acute Covid https://t.co/Y6NHGkKTHV #LongCovid @ArturFedorowski @NatRevCardiol https://t.co/oEOGU4EmQV

2023-02-02 23:57:02 Dignity-based medicine "Respecting the dignity of the patient as a knower suggests that expertise should also include the expertise of patients—on their body, their experience of pain or joy, and how they weight the risk of harm against benefit" https://t.co/UgyNum3j5q https://t.co/PDwoBMw6wR

2023-02-02 23:20:24 The promise for T-cell therapies has jumped from their success in refractory blood cancers to approaching solid tumors, autoimmune conditions, and anti-scarring, along with many new ways to engineer the cells https://t.co/2m7WF34Pj3 https://t.co/NX6vPfmJ18

2023-02-02 18:08:30 New CDC report on bivalent booster protection vs XBB.1.5 variant infections https://t.co/DXz5pVEbg5 https://t.co/0uo1kHpYFR

2023-02-02 16:13:07 Good new rundown on bivalent booster benefit https://t.co/mGmGjb0e3s by @SmithDanaG @NYTHealth https://t.co/s4Cofcsxsk

2023-02-02 15:13:52 @PeacockFlu @LongDesertTrain Right, thanks to Ryan. And your new report culminating in this https://t.co/RzxY7Xdv92

2023-02-02 04:05:22 RT @EricTopol: The future of Covid vaccines that we need now, a new feature @Nature by @ewencallaway, including nasal, for mucosal immunity…

2023-02-02 00:19:23 A terrific new review of our innate immunity @NEJM today, with relevance to #SARSCoV2 and Covid https://t.co/xpEMyzmgKK https://t.co/0kQW9y6bPg

2023-02-01 20:51:49 RT @ScrippsRTI: Immunocompromised people are increasingly on their own when it comes to protecting themselves against COVID-19. @EricTopol…

2023-02-01 19:56:16 Ready for a smart toilet? https://t.co/agsdJb2kqx @ScienceTM I'm not. But it could be a good research tool for data collection for willing participants https://t.co/zkyfxJMbLw

2023-02-01 18:07:26 This was the "Dream Vaccine" exceptional @Sciencemagazine article by @sciencecohen nearly 2 years ago. Next generation vaccines are not a dream—they could have been a reality by now https://t.co/K7D2L3hNbY https://t.co/2btmXVGFZr

2023-02-01 17:59:06 RT @WHCOS: As COVID cases rose in Dec/Jan, ICUs were not crushed this time? Why? The world-leading @WHCOVIDResponse plan to make paxlovid…

2023-02-01 17:28:14 See @loganawalsh's explainer thread and congratulation to this @mcgillu team for both seminal papers! https://t.co/52549BKbwc

2023-02-01 17:24:48 One of the hottest fields is biomedicine is spatial resolution of #cancer via millions of single-cell mapping + #AI. Elucidating pathobiology and better ways to Rx 2 papers @Nature today on the brain and lung https://t.co/NfCCORa0ak https://t.co/tfQqaeMPY5 https://t.co/SSZ0J8bddm

2023-02-01 16:48:19 @ahmkep Here's the rest of the article https://t.co/uYHAUfhikC

2023-02-01 16:40:23 How the time of day may affect cancer treatment https://t.co/i7ur2E83df @Nature @NatureNV https://t.co/raKvPEQwUt

2023-02-01 15:20:35 RT @Medscape: .@EricTopol and @cuttingforstone chat with the UK's professor @FryRsquared about taking risks and asking the right questions.…

2023-02-01 14:43:20 For nasal vaccines we got the first results from a large, randomized trial yesterday which were encouraging for inducing better immunity and less side-effects vs shots https://t.co/ufxF2r04wQ https://t.co/P28GNuXW0G

2023-02-01 14:27:55 The future of Covid vaccines that we need now, a new feature @Nature by @ewencallaway, including nasal, for mucosal immunity, and universal, more durable, variant-proof ones with less side effects https://t.co/9U5xO2Ve1B https://t.co/Mb8mHtDSVW

2023-02-01 01:53:38 An African lion in a zoo, deer reservoir, #SARSCoV2 probable transmission and spillover, respectively https://t.co/kcoJx00UUd @PNASNews https://t.co/Lf9JpLyClJ https://t.co/c3iBod1GBA

2023-02-01 00:55:58 RT @EricTopol: The 1st results for the @BharatBiotech nasal vaccine (BBV154, approved in India) randomized trial vs shots now posted, super…

2023-01-31 19:29:00 Accompanying text https://t.co/Sxf34WhrD4

2023-01-31 19:19:53 A good diagram by @daniella_raz @TheEconomist Example: —95% of Americans age 65+ have had at least 2-shots —Most Covid deaths are in people age 65+ who are vaccinated —There's still ~90% reduction of death for vaccinated vs unvaccinated https://t.co/oq3jBYkNly

2023-01-31 18:35:29 2. Pharmacists unwilling to prescribe Paxlovid, even though empowered (these are results from new @Medscape survey) 3. Dr. Jha is a champion for developing nasal and universal coronavirus vaccines and explains why it hasn't happened (yet)

2023-01-31 18:35:28 My interview with @AshishKJha46, leader of the @WHCOVIDResponse, about the pandemic We covered many important issues https://t.co/dzSNMOCQRH 1. Underuse of Paxlovid in older patients: not backed up by low incidence of rebound and ease of sidestepping potential drug interactions

2023-01-31 17:53:18 RT @JamesSurowiecki: An effective nasal vaccine for Covid would be exceptionally valuable.

2023-01-31 17:20:49 @YaleSPH @kmpanthagani @meganranney Terrific news. Congrats Megan!

2023-01-31 17:08:27 @AstroKatie @BharatBiotech There are no head-to-head trials of mRNA vs Covaxin so hard to know, different populations and tracking of outcomes. Data posted is for immune response and side effects only

2023-01-31 17:01:38 T and B cell responses for nasal vaccine (2 doses) vs Covaxin shots (2 doses) https://t.co/NBQ84Fgs2Y

2023-01-31 16:58:18 The 1st results for the @BharatBiotech nasal vaccine (BBV154, approved in India) randomized trial vs shots now posted, superior antibody and cellular immune response (vs ancestral and Omicron)

2023-01-31 16:41:00 And now the @JAMA_current editors weigh in https://t.co/qXaZNQ4oKU @AFlanagin @KBibbinsDomingo https://t.co/GMNk6qYrvu

2023-01-31 16:31:05 The CDC quietly posts these data on their website (Jan 25th latest installment) which counters the myth that only people age 65+ derive survival benefit from boosters. There is nothing magical about a particular age cutoff-—it's a subgroup analysis used to support one's beliefs

2023-01-31 16:24:58 The #AI machine vision kicks in for the gastroenterologist late in the day when fatigue sets in: nearly 4-fold better performance for polyp detection in randomized trials https://t.co/eb1jhDkZMA @JAMANetworkOpen https://t.co/HNGm2Tfq2D

2023-01-31 16:00:12 The underused Covid treatment https://t.co/XcvEFol8A4 by @germanrlopez Significant reasons, as verified by the new @Medscape survey, are the exaggerated concerns about drug interactions and rebound not backed up by data

2023-01-31 15:00:05 More on the link between persistent infections and #LongCovid Among 381 infections lasting 30+ days, a 50% higher rate compared with infected controls https://t.co/MyUcgwIEvV

2023-01-31 13:59:46 Only high-income country without universal healthcare coverage https://t.co/Lmc6ULjHkZ

2023-01-31 13:59:45 Worst maternal and infant mortality https://t.co/NsUN0pQ6zK

2023-01-31 13:59:44 Highest death rate from Covid https://t.co/1QR82VHC6Y

2023-01-31 13:59:42 With highest spending https://t.co/EyofQqhDJu

2023-01-31 13:59:41 The United States, the perennial outlier when it comes to healthcare spending and outcomes New data through 2021 vs peer countries by @commonwealthfnd https://t.co/qa9q75IEJB Worst @OECD life expectancy https://t.co/2tBkW9b7SH

2023-01-31 03:27:19 “I don’t think that the conventional cardiac surgeon, as we know him, will exist in a few years’ time” https://t.co/EkOEoBuczZ by @simonakam H/T @herbgreenberg https://t.co/A2AoWtcUYB

2023-01-30 23:52:43 Immune imprinting of #SARSCoV2 and its potential benefits https://t.co/ze970tAN99 @TheLancetInfDis by @CiesekSandra @SebastianHoehl https://t.co/jU6rYu2kyv

2023-01-30 23:28:38 Updated @CDCgov data on bivalent booster, age groups and deaths Overall 91% reduction of deaths across all age groups vs unvaccinated, less (80%) without bivalent booster The absolute reduction increases w/ age

2023-01-30 18:49:41 Innovation in cancer vaccines to markedly increase cancer antigen-specific T cells and activation of these cells @natBME @CHADNANO @DrMTeplensky @MirkinGroupNU @NUFeinbergMed @IINanoNU https://t.co/rLXCM7OI4r https://t.co/HEFCqldgqd

2023-01-30 18:17:49 RT @mehdirhasan: It’s mild! It’s like the flu! It doesn’t affect kids!

2023-01-30 16:43:01 fixed link https://t.co/5FV3Gn0tUw

2023-01-30 16:40:15 New support for autoimmunity as a component for triggering atherosclerosis via CD4+ T cells https://t.co/d5EI71E8gV @mariedepuydt @UniLeidenNews https://t.co/LpjCBSMoNV

2023-01-30 16:10:37 From an analysis of 42 studies in 15 countries, "students lost out on about 35% of a normal school year's worth of learning" during the Covid pandemic https://t.co/yYm4nLNTob @NatureHumBehav https://t.co/iUMwWDjDEY

2023-01-30 16:03:45 "In this study, COVID-19 was a leading cause of death among individuals aged 0 to 19 years in the US." @JAMANetworkOpen https://t.co/AWawqJ0KLl by @flaxter and colleagues https://t.co/BIokfnMDez

2023-01-30 15:06:07 @hholdenthorp @DukeMedSchool @DavidJSkorton @AAMCtoday @Bob_Wachter It’s amazing it took this long for med schools and universities to stand up

2023-01-30 14:33:37 Some years ago, owing to the formidable and practical challenges, I thought the chance for T cell therapy to make a difference would be minimal. That's changing. https://t.co/2m7WF34Pj3

2023-01-30 01:00:00 CAFIAC FIX

2023-01-17 00:05:50 Mapping XBB.1's antigenic distance (among others): "We observed that human post-vaccination neutralisation titres reflected the antigenic map, as the largest reduction in neutralising titres compared with the D614G variant" https://t.co/epa5txNqqw @LancetMicrobe @bart_haagmans https://t.co/oEIeUKt8HR

2023-01-16 21:20:11 "I would advocate *not* moving fast and breaking things." —@demishassabis https://t.co/lvGrs8mwVl @TIME @billyperrigo on LLMs

2023-01-16 20:35:54 Important work andby @SystemsVirology to characterize the XBB.1.5 variant. Fortunately, our immunity wall in the US is helping to blunt its impact to be much less than Omicron BA.1. Could be even less w/uptake of bivalent vaccines and mitigation https://t.co/mnaA3kemLp https://t.co/XRU6WCgsiW

2023-01-16 18:40:55 @VirusesImmunity @ahandvanish @LisaAMcCorkell @juliamv Thanks Akiko!

2023-01-16 18:40:43 RT @VirusesImmunity: Amazing, timely, comprehensive, and evidence-based review - Long COVID: major findings, mechanisms and recommendations…

2023-01-16 17:58:54 If you're not keeping up on the disruptive power of #AI chatbots, you might want to read these from today https://t.co/DFTGcMFTaq @NathanSanders_ @schneierblog @BKCHarvard @nytopinion https://t.co/dFjsgjYwGA @KalleyHuang https://t.co/X9FyYh2IyH

2023-01-16 17:33:35 We keep ignoring somatic mutations in the blood (CHIP) as an important risk factor for atherosclerotic cardiovascular disease, cancer, and all-cause mortality. Now a mechanistic underpinning: TP53, damage repair genes, unraveled @NatureCVR https://t.co/XttD6KynW4 https://t.co/5Oh5WUMCN6

2023-01-16 17:18:09 @terrigriffith @SFUBeedie That was the intent. Many thanks!

2023-01-16 17:13:38 Just published @NatureMedicine An astute take on the future of clinical trials and evidence-based medicine, in the digital and #AI era, by @VivekSubbiah https://t.co/625WIwa6Qx https://t.co/cLpfZKAiMI

2023-01-16 15:53:04 I review the transformative potential of #AI in medicine, now in the era of LLM/Foundation Models, in this new post, with the links to the above exams and much more https://t.co/2Axg5C4HtT

2023-01-16 15:53:03 3. US, 2022, the large language model (LLM) Med-PaLM takes the US medical licensing exam. A huge (33% relative) jump in accuracy of answering medical questions: 92.6% doctors say the AI was correct vs 92.9% other doctors were correct. Now replicated by ChatGPT. https://t.co/16itDiq3LF

2023-01-16 15:53:02 The #AI takes the medicine qualifying exam. Three to take note: 1. China, 2017, Xiaoyi passed the licensing exam with a score of 456 (passing 360-600) based on memorization and information recall, with poor performance on patient cases https://t.co/Aq3fuDiOBP

2023-01-16 14:38:38 For more on pacing (top row of the Table), a very good piece by @AmandaMoMorris today @PostHealthSci https://t.co/jTE6rmXF6p

2023-01-16 01:50:44 @Mon4Kooyong Thanks and agree on the sure fire way to prevent #LongCovid

2023-01-15 19:44:42 You've been hearing a lot about ChatGPT, DALL-E, Stable Diffusion and other foundation #AI models (also known as Large Language Models or Generative AI) lately. How are they beginning to impact medicine and healthcare? https://t.co/2Axg5C4HtT

2023-01-15 18:36:02 Sorry, I gave the wrong twitter handle for my @ScrippsRTI colleague, @julialmv. That gives me a chance to note she is currently leading this important research project to help immunocompromised individuals https://t.co/cJb7tBzJGs

2023-01-15 18:30:31 Foundation #AI goes to the movies "A.I. could create in minutes what a filmmaker worked on for years" https://t.co/Af4aU6MOg9 by @frankpavich https://t.co/ISUVLIgw7U

2023-01-15 18:26:18 It is sad to see that things have gotten worse in Japan, with fatalities towering above its prior waves https://t.co/4GVLATIav4 https://t.co/4lccBLVoky

2023-01-15 00:58:46 RT @doctorasadkhan: This is THE #LongCovid paper. Comprehensive yet accessible, jam packed with everything you need to know. Science 1-psyc…

2023-01-14 22:58:51 An excellent review of the challenges surrounding highly effective and durable nasal vaccines to achieve mucosal immunity vs respiratory viruses (including #SARSCoV2) https://t.co/TCQKwpCYKO by @NIAIDNews @cellhostmicrobe H/T @mtosterholm https://t.co/0iY0ec2HJA

2023-01-14 17:34:18 The ~80% bivalent booster vaccine effectiveness (US and Israel studies) summarized is compared to controls with prior infections, vaccinations and boosters, making that high level of protection for people age 65+ noteworthy

2023-01-14 17:30:39 The US did a great job getting its seniors vaccinated, with 94% having the primary series of 2 shots. But in the last 6 months, less than 40% have gotten a booster, and they account for most of the hospitalizations and deaths https://t.co/tR5S4BBaYb

2023-01-14 17:03:24 New insights on the gut microbiome-brain axis, based on https://t.co/kU2nnGA0uB @dongohseo1 and colleagues with @ScienceVisuals https://t.co/ndd8MfLa8P

2023-01-14 17:03:23 "These exciting results highlight the potential to harness the gut microbiota to prevent or slow the progression of AD and other tauopathies and raise awareness about the potential long-term effects of early-life diet" https://t.co/c4Xh83gekQ @Tan_ee_Ya @YuemingLiLab https://t.co/lLz2meYgR0

2023-01-14 15:00:15 RT @ahandvanish: Our review of #LongCovid research is out! This was a HUGE labor of love over 10 months from @julialmv @LisaAMcCorkell @Er…

2023-01-14 14:17:13 @zalaly @ahandvanish @LisaAMcCorkell @julialmv @NatureRevMicro Thanks Ziyad! Much of what we know about #LongCovid comes from your outstanding research contributions

2023-01-13 23:39:12 RT @loscharlos: Absolutely incredible work — a comprehensive overview on the explicit biological abnormalities of #LongCovid — thank you @E…

2023-01-13 23:39:06 RT @DrCaliff_FDA: The bivalent COVID-19 vaccines have been associated with a significant reduction in hospitalization and death in all popu…

2023-01-13 22:30:25 @CrabbBrendan @ahandvanish @LisaAMcCorkell @juliamv @NatureRevMicro Thanks Brendan!

2023-01-13 22:06:22 @nickiykwim @ahandvanish @LisaAMcCorkell @juliamv @NatureRevMicro Thanks for noting this Correct link @julialmv

2023-01-13 20:48:36 This was an outgrowth of a very long process, with multiple rounds of peer and editor reviews. In a field constantly updating. But it was all worth it to have the privilege to work with 3 all-star co-authors, each of whom have had #LongCovid. We hope you'll find it useful

2023-01-13 20:29:26 I amended my extensive review of the bivalent booster this week, which works better than expected, to comment on this issue https://t.co/tR5S4BBaYb

2023-01-13 20:29:25 Today the CDC reported a possible safety concern about the Pfizer bivalent vaccine, unconfirmed by any other dataset https://t.co/on5LcVmNwz @lauriemcginley2 @bylenasun https://t.co/Fwqg7YLpFn

2023-01-12 23:35:12 A couple of corrections to the Table, thanks to @BarouchLab —Moderna used a pseudovirus assay —The Suthar (Emory) study changed from 4-fold (bivalent vs original) to 2.3-fold vs BA.5 from their preprint to the @NEJM report https://t.co/cHyo16WjSE

2023-01-12 21:15:36 "These findings highlight the key role of antigen presentation at the mucosa and support a protective effect of mucosal immunity for up to 8 months" https://t.co/zUuVnRamin What nasal vaccines could simulate to achieve durable mucosal immunity https://t.co/lZv2BqyXh4

2023-01-12 19:29:28 RT @GeoffreySupran: NEW: In @ScienceMagazine today, our latest peer-reviewed research shows Exxon scientists predicted global warming with…

2023-01-12 17:27:15 For decades the #AI field has loosely used the term artificial neurons. Now they've really been made https://t.co/qpinCVNyEk artificial neurons that closely mimic the characteristics of biological nerve cells @NatureMaterials

2023-01-12 17:10:04 The problem of reduced T-cell immune response (CD4+) for people age 65+ to Covid vaccination https://t.co/kn5DAx8G2Z @NatureAging https://t.co/2djizJJc8P

2023-01-12 17:02:14 Beyond grim. A humanitarian crisis https://t.co/I7LJsdbbcm by @lilkuo https://t.co/EiyDxT9RRO

2023-01-12 16:56:27 Good news: In the Northeast where the XBB.1.5 variant now accounts for >

2023-01-12 15:51:27 RT @NightShiftMD: Read the fantastic review by @EricTopol. The bivalent booster dramatically prevents hosp and death esp in older patients…

2023-01-12 13:58:36 RT @Bob_Wachter: Important thread: @EricTopol was a bit skeptical about the bivalent when it rolled out. His detailed review of emerging la…

2023-01-12 02:13:26 I was quite skeptical in September when the bivalent was rolled out without human data. Now there’s compelling evidence to support its benefit.

2023-01-12 00:10:28 Fixed link @bmj_latest https://t.co/grs74wi8f4

2023-01-11 23:40:11 3. The vaccinated individuals did better: less dyspnea and more likeness to controls. 4. Children had more Strep throat &

2023-01-11 23:40:10 2. Major symptoms of difficulty breathing, cognitive impairment and weakness were present at 1 year. Also loss of smell, taste, dizziness and cough https://t.co/bF6hIauesm

2023-01-11 23:40:09 A new retrospective nationwide EHR assessment of #LongCovid in ~230,000 people w/ mild Covid and matched controls for age, sex, vaccination status, variant Some downplaying of persistent symptoms at 1 year: 1. Median age of cohort = 25 years. People age 41-60 had worse outcomes https://t.co/BV5qyoxQHU

2023-01-11 22:00:50 The Covid bivalent vaccine booster works better than expected. I've reviewed the cumulative data https://t.co/tR5S4BBaYb That's in contrast to a @NEJM essay today and 2 lab studies that used a pseudovirus assay without assessing the XBB variants

2023-01-11 19:58:14 Cell-free DNA fragmentation patterns and sequencing from small amounts of plasma hold considerable promise for screening and early detection of cancer https://t.co/9FRzcWj9Pj @ScienceTM https://t.co/ui6GlTSzyg

2023-01-11 19:05:38 Some #SARSCoV2 mutations that confer resistance to Paxlovid have been deposited @NCBI &

2023-01-11 18:28:23 Immune evasion of #SARSCoV2 typically refers to our antibodies having less neutralization capacity vs new variants. But our 1st line of defense, the innate immune system—interferons—also play a critical role as elegantly reviewed https://t.co/eCw4D5BslI @JudyMinkoff @virusninja https://t.co/jC64iN7Hx5

2023-01-11 18:01:02 @AshishKJha46 Referring to this brief thread post https://t.co/3LZnn5o3SU

2023-01-11 18:00:06 The Table accompanying this post was inadvertently deleted https://t.co/DMZlKiW4PZ

2023-01-11 17:54:53 RT @AshishKJha46: Dr. Topol is right. The evidence from high quality studies is clear: The bivalent vaccine is far superior to the origi…

2023-01-11 16:58:02 RT @WesElyMD: “China’s in the midst of a #Covid crisis w unmitigated spread &

2023-01-11 16:33:29 Health advice :-) by @stephanpastis https://t.co/PIB2TzkQup

2023-01-11 16:19:40 The lack of reproducibility issues that haunt medical #AI https://t.co/bG5ANEx2u4 @Nature https://t.co/jz5TJ8cyse

2023-01-11 04:03:40 An outstanding appraisal of #SARSCoV2 evolution as an antigen, the potential role of immune imprinting (original antigenic sin), and strategies to prevail https://t.co/OJGA1RA4kn @jclinicalinvest @MarionKoopmans @GijsbertNierop https://t.co/LaZvpQqXNZ

2023-01-10 20:54:27 While the bivalent booster was directed against BA.5, fortunately it broadens immunity and works better than the original booster for inducing antibodies vs BQ.1.1 and the XBB variants. Live virus assays are more reliable than pseudovirus

2023-01-10 20:44:17 Summary of the 8 lab studies for the bivalent BA.5 vaccine booster vs original. Neutralizing antibody (nAb) levels vs BA.5 and XBB variants All 5 live virus studies showed significant increase (3-8 fold) nAb increase for bivalent vs BA.5 and some cross-immunity vs XBB https://t.co/r4UuBdobhE

2023-01-10 17:57:36 "These data demonstrate that MVA-S vaccination confers a complete protection against #SARSCoV2 brain infection and the associated neuropathological damage (neuronal loss and vascular damage), even after a second viral infection." https://t.co/rHzB2Yu4hD @NatureNeuro @ibis_sevilla https://t.co/rzGOTPkeAe

2023-01-10 16:59:16 Bacteria play a more significant role in cancer than we previously envisioned, as we've recently been learning via spatial genomics https://t.co/E0tvczq68A @ImmunityCP @natedandy_PhD @sangerinstitute https://t.co/mi9MqNbxc3

2023-01-10 14:32:06 "The bivalent booster vaccination enhanced neutralizing antibody titers against all Omicron lineage viruses tested, including a 10-fold increase in neutralization of BQ.1 and BQ.1.1 viruses that predominated in the US." https://t.co/MbyhV05r9j

2023-01-10 14:15:03 “It’s almost certainly going to dominate in the world. I cannot find a single competitor now. Everything else is incomparable.”—@yunlong_cao https://t.co/bo13QV7xVo

2023-01-09 22:16:05 Let's create some proteins [Stop dilly-DALL-E-ing with silly images] Potential for foundation #AI models to impact life science https://t.co/kbqTbzDWzn @CadeMetz https://t.co/4C7Pa6kF9n

2023-01-09 21:55:02 These data align with the recent CDC analysis https://t.co/rqkjmug1ki

2023-01-09 20:47:44 The bivalent booster in people age 65+ compared with those who did not receive it, among >

2023-01-09 19:35:47 Cancer cells can change the shape of their nucleus to facilitate their spread throughout the body

2023-01-09 16:36:49 So powerful. Unforgettable. Thank you @celinegounder https://t.co/I9DoGvlJpW https://t.co/8BCe7j3bzV

2023-01-09 16:25:18 The association of healthy heating habits and reduced mortality in 2 large cohorts, ~120,0000 people, with up to 36 years follow up. across all racial and ethnic groups https://t.co/qcpcuCdxzX @JAMAInternalMed with the usual diet study caveats @HarvardChanSPH https://t.co/MZ8nCJfyBX

2023-01-09 15:45:26 Our digital times :-) https://t.co/5wC9nvEZ0T

2023-01-09 15:20:36 The virus is talking. We're not listening https://t.co/k6ymRyUE6f https://t.co/7JOxoWbu3R

2023-01-09 00:49:15 “The implications of XBB.1.5 are also much bigger than just this formidable variant. The virus is talking to us, and it is telling us it has many more ways to evolve.”

2023-01-09 00:25:52 “That [XBB.1.5] should serve as a wake-up call for the country to re-invest in new vaccines, treatments and pandemic monitoring”

2023-01-08 16:30:40 What the XBB.1.5 variant is telling us. And what we can do about it. My oped @washingtonpost https://t.co/k6ymRyUE6f @PostOpinions https://t.co/PQnsAl0YzZ

2023-01-08 03:31:52 RT @HamlinIsland: Putting love into the world comes back 3xs as much… thankful for everyone who has reached out and prayed. This will make…

2023-01-07 22:37:46 The poor pharma industry https://t.co/oZ7fhX3D9i by @david_wainer "It’s in the industry’s best interest to say the sky is falling”—@DusetzinaS https://t.co/3g0cdrdiXo

2023-01-07 19:30:37 There are important differences between multisystem inflammatory syndrome in children (MIS-C) vs Kawasaki's disease, but still much to learn about its pathophysiology https://t.co/TIg9U0knK0 https://t.co/j3YU5eq78f

2023-01-07 19:22:08 Good graphic to convey an important negative trend https://t.co/2f2TaSsogQ @maxdkozlov https://t.co/i3WYhUI3f7

2023-01-07 19:02:39 @RickABright @GISAID Community extrapolation only, unfortunately

2023-01-07 18:50:36 But in North Carolina, with much lower % XBB.1.5, a similar spike in hospital admissions among seniors, which supports other factors besides this variant as a principal driver https://t.co/1nk28wAwHT

2023-01-07 18:50:35 The notable rise of Covid hospitalizations in the Northeast, where XBB.1.5 variant accounts for ~75% cases, among people age 70+, especially in Massachusetts (approaching ~80% of its BA.1 wave) https://t.co/OYKQV32gvz https://t.co/aVyTHlHXiQ

2023-01-06 22:06:50 RT @aetarke: Can CD4+ T cells cross-recognize different coronaviruses (CoV), offering immune protection from potential future CoV pandemics…

2023-01-06 19:24:21 You would think the ⁦@US_FDA⁩ would have learned from Aduhelm. This drug is not deserving of any accelerated approval https://t.co/AsbZSO0RhF

2023-01-06 17:23:27 New York, where the XBB.1.5 variant was first detected, and the US bellwether for its growth, still shows signs of increasing hospitalizations, particularly for those age 70+ https://t.co/3YFO480SJ6

2023-01-06 17:16:37 Northeast region dominance of XBB.1.5 unchanged, 5 of the 8 regions still in single digits https://t.co/013DOVZXwF

2023-01-06 17:16:36 New @CDCgov #SARSCoV2 variant report Corrects/ lowers XBB.1.5 proportion of new cases from ~40% (last week) to 28% nationally now, leaving more runway before this variant achieves dominance cross country. No other variant showing growth https://t.co/jjl2AnOYb5 https://t.co/SGHJmQ12NH

2023-01-06 06:06:36 I’d reject their proposal for various reasons, but will let you and respondents air it out

2023-01-06 05:43:03 A new explanatory model proposed for #LongCovid https://t.co/62ztuTDsPH @LancetRespirMed "an embodied condition with heterogeneous biological, psychological (experiential), and social (or environmental) factors integrated in complex relationships" https://t.co/8ygX8cYeqc

2023-01-06 00:59:42 A new study finds no indication of autoantibodies, an intact immune response vs controls (antibody and T cell) but evidence of persistent, elevated circulating full-length spike protein unbound by antibodies https://t.co/mdYuj6x2Ww https://t.co/0OSC1NNg0g

2023-01-05 20:08:04 The essentiality of wastewater surveillance "Core component of infectious disease monitoring, providing a variant-specific, community-representative picture of public health trends that captures previously undetected spread and pathogen transmission links" https://t.co/D0D8WcP2bM

2023-01-05 19:57:47 How obesity can induce neuroinflammation: Reprogramming innate immunity, particularly macrophages (via epigenetics), can facilitate age-related macular degeneration in an experimental model https://t.co/Q1seFXIxwk https://t.co/JPEsOfWlSg @ScienceMagazine https://t.co/5jQMrO4hZ7

2023-01-05 19:44:40 The hidden humanitarian Covid crisis in China https://t.co/3ejhlzkLvv @ScienceMagazine https://t.co/vUaOtrxJAm @joyuwang @kaltoons https://t.co/dNAfxw21Iq @hj257 https://t.co/ymFhguPllj

2023-01-05 17:39:35 "All around the world, Covid surveillance is faltering. That, rather than the surge of cases in China, is the main reason for worry" The number of sequences submitted @GISAID has dropped 90% https://t.co/noDmDB4bDZ

2023-01-05 00:58:42 RT @TWenseleers: @BrunnCarrigg @Tuliodna @EricTopol Also see graph below. There is some registration delays apparently... https://t.co/ECnM…

2023-01-05 00:58:33 RT @TWenseleers: @BrunnCarrigg @Tuliodna @EricTopol The effect, like for BQ.1, will be felt mainly by seniors (which is perhaps why Tulio t…

2023-01-04 23:08:43 https://t.co/rHe6SJNWsg

2023-01-04 23:07:45 From studying transmission of the Delta and Omicron variants in nearly 2000schools and 300 preschools in Australia: “community restrictions, rather than school closures, best mitigated COVID-19 impacts.” https://t.co/wOruadiPk8…

2023-01-04 19:17:36 @Tuliodna Dear Tulio, I don’t think it’s being overplayed due to its remarkable growth advantage and very rapid rise to dominance here and likely much of the world But I agree that our immunity wall will undoubtedly blunt its impact

2023-01-04 19:12:51 “Our results highlight the importance and feasibility of a universal vaccine to fight against SARS-CoV-2 antigenic drift.” @ScienceTM https://t.co/yrNkWjQwb2

2023-01-04 18:21:31 No, vaccines DO NOT induce variants. That's what infections do. Blatant misinformation: "Growing evidence also suggests that repeated vaccinations may make people more susceptible to XBB" https://t.co/JroxuQpxe8

2023-01-04 17:55:53 The #SARSCoV2has been relentlessly evolving over the past 3 years to find new hosts. Its latest iteration, XBB.1.5, acquired a critical double mutation that maintains high level of immune escape while increasing infectivity by @yunlong_cao and colleagues https://t.co/32QqpChRVR https://t.co/M2GxCbmcgs

2023-01-04 17:27:58 Science and technology are getting less disruptive on the basis of 45 million papers and 3.9 million patents published in the past 6 decades https://t.co/7RxiutNR9z @Nature @russellfunk @michae1park https://t.co/RHLYmJYQz6

2023-01-04 16:35:32 The breakthrough obesity drugs, a new feature @Nature https://t.co/wXRkQe0Tyw by @meprillaman aligns with my recent review https://t.co/SMZO20WGRs https://t.co/VxLQzCwHzN

2023-01-04 16:28:20 The @UF faculty report on Florida surgeon general Ladapo's "seriously flawed," "careless, irregular, or contentious [vaccine] research practices" https://t.co/W7JQsRUWlT https://t.co/r2HxNltPve

2023-01-03 23:05:34 Why hasn't Paxlovid implementation lived up to its expectations? Prescribed for only 13% in the US &

2023-01-03 21:36:50 A hopeful turning point for Japan after having gone through its worst wave for fatalities https://t.co/ifrPlXXEdc

2023-01-03 21:19:07 @JohnKasich @vkhosla Meanwhile, for comic relief you can't beat @themattfriend https://t.co/RtXHTP5kYw

2023-01-03 21:11:36 Exceptional new reviews of the 12 interconnected biologic hallmarks of aging @CellCellPress and cancer @Cell_Metabolism https://t.co/WViWtj4NK6 https://t.co/WRDQokSbiZ https://t.co/NIWny2torf

2023-01-03 16:53:30 @TWenseleers Much appreciated, Tom

2023-01-03 01:01:35 ~63% of Americans age 65+ have not had a recent/bivalent booster, leaving them vulnerable —Lab data supports some bivalent booster cross-immunity protection vs XBB.1.5, even though it was BA.5 directed —Before XBB.1.5 becomes dominant across the US, that's a way to help defend

2023-01-03 00:45:47 That's >

2023-01-03 00:43:38 I reviewed all we know about the XBB.1.5 variant 10 days ago, w/its high transmissibility https://t.co/mnaA3kemLp The ? now is whether it will have a material impact on adverse outcomes, for which there is some evidence among seniors in states with >

2023-01-02 19:55:06 Annual sales of tirzepatide (Mounjaro) may reach $48 billion, far surpassing prior records. I reviewed why these new obesity drugs are a breakthrough, but also a liability https://t.co/FUYOzzzm73 https://t.co/SMZO20WGRs

2023-01-02 19:49:58 Unraveling #Alzheimer's disease by single-cell genomics, a new tour de force review https://t.co/Wihfht4gbe @NatureNeuro @mhmurdock1 @DrLiHueiTsai @MIT https://t.co/R0B7Jwa6WW

2023-01-02 17:31:06 Comparative effectiveness of Pfizer vs Moderna booster shot in US Delta and Omicron waves via large @DeptVetAffairs experience https://t.co/ecVit591vO Significant less symptomatic infections and hospitalizations among those treated with Moderna @NatureMicrobiol https://t.co/8lV7RpmRni

2023-01-02 17:19:32 abstract and key figure https://t.co/jSVOfYQJna

2023-01-02 17:11:42 New @NatureMedicine Proof that Covid vaccines do reduce Omicron transmission from prison data, but the impact is ~20-40% https://t.co/du9ABpahEq

2022-12-31 22:31:29 RT @BNOFeed: BREAKING: Number of Americans hospitalized with COVID-19 rises to 45,279, the highest since February

2022-12-31 22:29:13 RT @JPWeiland: I can confidently say XBB.1.5 will NOT approach the levels of hospitalizations and deaths seen in the initial Omicron wave i…

2022-12-31 18:33:05 Where were the major #SARSCoV2 variants that led to continental or global dominance first detected? Alpha—United Kingdom Beta—South Africa Gamma—South America Delta—India Omicron—Southern Africa XBB.1.5—United States

2022-12-31 18:19:50 “If you make a big bet, and you’re successful with a program [Operation Warp Speed], you should keep making big bets" https://t.co/zHVRYmP4vW @SmithsonianMag by @SimarSBajaj

2022-12-31 18:05:04 @bwizel @TRyanGregory Thank you!

2022-12-31 16:24:03 RT @Ideas_Sleep: 'The UK is incontrovertibly the world leader in genomics' – @EricTopol In 5-10 years, the UK looks set to lead the way i…

2022-12-30 21:13:00 RT @BNOFeed: Number of Americans hospitalized with COVID-19 rises to 44,138, the highest in more than 5 months

2022-12-30 20:06:17 Here for all ages 18+ Similar relative reduction, less absolute, for bivalent vs non-bivalent or without vaccination https://t.co/M2Bu9r1YTe https://t.co/CMKyrM4pl6

2022-12-30 20:00:31 New data for bivalent protection vs Covid hospitalization For age 65+, >

2022-12-30 17:34:58 Current US regional variant map. XBB.1.5 just getting started in multiple regions https://t.co/XM3fjdtoYB

2022-12-30 17:18:57 @JuliaRaifman Right, Julia. Unfortunately, That’s the XBB.1.5 signature seen in many Northeast WW in recent days

2022-12-30 17:16:26 All we know about the XBB.1.5 variant summarized here a week ago https://t.co/mnaA3kemLp We’ve not seen such rapid growth of a variant since Omicron BA.1 a year ago. Total US XBB last week = 18% of cases. Northeast now ~75% XBB.1.5. Perhaps CDC and media will finally take note

2022-12-30 17:05:15 Wow. XBB.1.5 more than doubled across the United States in 1 week, now ~40%, out-competing all variants https://t.co/PeE8P7eAeH

2022-12-30 16:14:48 @chrischirp Heading towards multi-continental dominance, first one USA evolved (first detected in New York)

2022-12-30 01:39:00 @ansonjtong You'll be hearing a lot more about it tomorrow (finally)

2022-12-30 01:38:24 Among the best @nytgraphics for 2022, this one for #LongCovid really stands out https://t.co/pYPLoTTQUj @joshkellerjosh

2022-12-29 19:50:11 "This is not how epidemiology works. One cannot extrapolate a death rate across a nation from a single death." —@kmpanthagani https://t.co/Le7cUb4nlI https://t.co/KQWzZkN4hY

2022-12-29 18:20:37 For people age 65+, the bivalent booster linked to >

2022-12-29 17:42:09 @jordan_peccia @kmpanthagani This is what XBB.1.5 looks like

2022-12-29 17:16:23 The predictive utility of a heart disease polygenic risk score for primary prevention, use of statins, especially in people less than age 50 https://t.co/hCMjfzTxgX @JAMACardio by @marstonMD and colleagues https://t.co/JmwBIKB4pu

2022-12-29 15:56:40 With focused on China, Japan, a country w/ one of the best pandemic outcomes, as previously reviewed: https://t.co/z68bDAQuhi is experiencing its worst death toll, during a 2nd BA.5 wave, with waning immunity, under-boosted, and 25% population age 65+ https://t.co/o7TgtHAgWn

2022-12-28 23:50:14 I asked why, with all the evidence, there is such resistance to accepting that masks help (for all respiratory viruses) https://t.co/rPJBJ0VjOh

2022-12-28 23:50:12 Transcript is now posted. Here is Prof @linseymarr explaining 1- and 2-way masking impact https://t.co/tkIvdxRmgd https://t.co/cbhQPkm4oT

2022-12-28 22:42:41 New @NEJM A randomized trial of an oral remdesivir analog drug (VV116) vs Paxlovid suggests it may provide an alternative (fulfilling the pre-specified non-inferiority criteria, but 1.17 hazard ratio) https://t.co/ytECEc0Fvb https://t.co/TmvZTCWDMe

2022-12-28 15:57:51 This is the summary of all @CDCgov and media coverage of the XBB.1.5 variant to date https://t.co/R5jKtidChB

2022-12-28 15:53:30 There are ~7 million Americans who are immunocompromised, more vulnerable to severe Covid, and now Evusheld rendered ineffective. We've just launched a new direct-to-participant-research program with free molecular tests &

2022-12-28 05:24:39 We’ve just launched a new research program for immuncompromised individuals in the US with free home molecular testing and rapid access to medications when needed. Please help spread the word https://t.co/PfZGBYjcQi

2022-12-28 02:22:28 I've updated this post on the XBB.1.5 variant with new data provided by @yunlong_cao, @JPWeiland and @rquiroga777. For those questioning what could be done if CDC/media raised awareness (for which there has been none), that is addressed, too. https://t.co/mnaA3kemLp

2022-12-28 01:53:57 @yunlong_cao @JPWeiland @LongDesertTrain Thanks Yunlong. That’s precisely the piece that was missing….that you’ve filled in once again

2022-12-28 01:13:39 @SystemsVirology @yunlong_cao @biorxivpreprint Thanks @SystemsVirology! Have you done any assays for XBB.1.5?

2022-12-27 23:19:45 RT @JPWeiland: I overlaid some of @trvrb group's analysis of effective Reproductive Number over time since a variant first starts spreading…

2022-12-27 20:18:17 It started in New York, now contributing in contiguous states, like Connecticut https://t.co/MOQpgmNWGl https://t.co/H6fLKYP2LU

2022-12-27 19:43:01 A functional @CDCgov would alert the public about the XBB.1.5 variant—which has already established dominance throughout the Northeast—and, with its big growth advantage over BQ.1.1, soon country-wide. https://t.co/tL2Y2HF2ew

2022-12-27 00:38:23 The Outlier 2021 US health care expenditures: $4.3 trillion

2022-12-26 23:38:46 @rquiroga777 Thanks so much, Rodrigo. I think your graphic is the best way to simply and accurately represent the progression of mutations that led to XBB.1.5. I revised the Substack post to include it https://t.co/mnaA3kemLp

2022-12-24 21:48:54 RT @LongDesertTrain: Excellent piece by @EricTopol on XBB.1.5, which @JPWeiland first called attention to a couple weeks ago. Nothing is ce…

2022-12-24 19:56:55 @macroliter Agree. To be announced soon

2022-12-24 19:15:21 @Globalbiosec Thanks so much, Raina. Very kind of you! All the best for the holidays

2022-12-24 18:38:54 Highly recommended for straight talk about airborne transmission of respiratory viruses (including #SARSCoV2) and how we can defend against it

2022-12-24 18:11:23 I've added citations to @jbloom_lab @LongDesertTrain @RajlabN. All indications are that XBB.1.5 will become dominant throughout the US in the weeks ahead, the 1st variant evolved here to have such marked growth advantage.

2022-12-23 22:48:03 Special thanks to the people who have been carefully tracking the variants, whose work is referenced in this post @yunlong_cao @JPWeiland @dfocosi @rquiroga777 @PeacockFlu @CorneliusRoemer @richardneher @siamosolocani @firefoxx66 https://t.co/pHj2uAkZiI @nextstrain

2022-12-23 20:31:57 @NoAutocracy Appreciate your feedback

2022-12-23 19:50:30 I wrote about the XBB.1.5 variant in the United States https://t.co/mnaA3kvpNp

2022-12-23 18:34:35 During surgery, frozen sections of tissue are obtained for key decision making (e.g. resecting a tumor) but there are problems w/ speed &

2022-12-23 18:23:31 "Our study demonstrates that [Molnupiravir] this commonly used antiviral can supercharge viral evolution in immunocompromised patients, potentially generating new variants and prolonging the pandemic." https://t.co/dRr0ifMF6t

2022-12-23 17:29:40 The good news is that the US flu season has peaked, started descent https://t.co/GoRVfCcLvn

2022-12-23 15:52:40 More here https://t.co/spPWEERiJf

2022-12-23 15:32:39 New York is the XBB.1.5 bellwether A brief thread on what's going on there and this variant https://t.co/B9hkn2MeeB

2022-12-23 15:30:20 New US #SARSCoV2 genomics indicates an important shift to XBB gaining on BQ.1.1. While the BQ.1s are dominant overall, the Northeast is now XBB dominant (particularly rapidly growing XBB.1.5) https://t.co/jjl2AnwOWX https://t.co/0wSbgRjtTK

2022-12-23 04:13:13 The 2 key mutations beyond XBB that appear to be linked to XBB.1.5's big growth advantage https://t.co/a1SGsKkRqr

2022-12-23 03:30:19 Look what's happening in New York State XBB (likely XBB.1.5) is quickly outcompeting BQ.1.1 https://t.co/uY35MktbbN https://t.co/XaOJRvMEnx

2022-12-23 03:20:29 What variant has the highest growth advantage of all in the mix right now https://t.co/PInFKwKIlz XBB.1.5 (based on a large number of sequences) https://t.co/ELJyQTlMlR

2022-12-23 02:07:28 If you like impersonators, Matt Friend is amazing His range seems limitless and he moves from one character to another like I've not seen before (maybe Robin Williams). https://t.co/nB91MxXL4t

2022-12-23 00:38:00 RT @linseymarr: What a delight to chat with @EricTopol for a @Medscape podcast about virus transmission and interventions!

2022-12-23 00:21:55 While the time to recovery was shortened, the price to pay is a very high rate of #SARSCoV2 mutations induced (its obligatory mechanism). That alarming rate has been amply documented by @LongDesertTrain https://t.co/RIPTr3useX https://t.co/ignWWSTU9B

2022-12-22 23:30:00 Just out @TheLancet Failure of Molnupiravir to reduce Covid hospitalizations or deaths in a very large randomized trial (N>

2022-12-22 21:42:17 Highest Covid hospitalizations in New York since January and soaring in seniors, as the XBB variant with added mutations gains growth advantage https://t.co/cz0BwwaIM3 https://t.co/AE7Gh7fQ1P

2022-12-22 20:04:00 My conversation this week with Prof @linseymarr, a civil engineer and leading authority on air quality, viruses, and the impact of masks. She's a remarkable explainer and my go-to expert on this topic https://t.co/cX7MPqhVjE #COVIDIsAirborne @Medscape

2022-12-22 19:16:03 Late after mRNA Covid vaccines, or with booster or breakthrough infections, there is a shift to IgG4 antibodies, not seen with adenovirus vector vaccines. The clinical significance is not known https://t.co/5thLxRwemm @SciImmunology @UniFAU https://t.co/YozSLVjVLd

2022-12-22 18:38:38 Another death in the lecanemab trial https://t.co/yX1xWdZ1TM @ScienceMagazine @cpiller

2022-12-22 17:58:15 RT @erikbryn: The news about life expectancy in America is devastating. Covid is taking a huge toll, but so are other causes like drug over…

2022-12-22 17:42:16 "We discovered large-scale mother-to-infant interspecies transfer of mobile genetic elements, frequently involving genes associated with diet-related adaptations." https://t.co/36B9VDy6QN by @tvatanen and colleagues @broadinstitute https://t.co/3aoXtFImGX

2022-12-22 16:57:02 BTW the cover of @CellCellPress this week shows #3D the aortic regions of a human heart whose vascular plaques are analyzed by DISCO-MS (#AI) technology (1st post in this thread) https://t.co/9n0KNUtS1T

2022-12-22 16:51:01 More jumps in the era of spatial omics 3D proteomics of intact tissue with #AI https://t.co/R7rhPr8jAj @CellCellPress @erturklab @labs_mann

2022-12-22 16:21:55 Great to see that we're making headway against KRAS, a driver of so many cancers that were previously untreatable by target. Two @NEJM reports vs the KRAS G12C mutation https://t.co/4ghBGdroZw https://t.co/1Y5nRDaBkF https://t.co/WSRRqMHoWp

2022-12-22 15:17:24 Now at a 25 year low, life expectancy in the US continues to fall. Covid persists as the 3rd leading cause of death and increasing ~20% over 2020 https://t.co/KldEystLDM @littlewern @jon_kamp https://t.co/hWpAGoQ49g

2022-12-22 01:21:01 @emollick Agree!

2022-12-21 23:53:08 When the #AI couldn't pass the radiologist qualifying examination @BMJ_latest (with special dispensation) @SusieShels @JWeirMcCall and colleagues https://t.co/CRGgMzdCTM https://t.co/m3aoYeAGZi

2022-12-21 22:59:26 Full text. One of multiple lab studies now to show the bivalent booster helps increase the immune (neutralizing antibody) response vs BQ.1.1 and XBB https://t.co/dejyM7rNrb

2022-12-21 22:01:00 New @NEJM "Persons who received the BA.5-containing bivalent booster had better neutralizing activity against all Omicron subvariants (especially against BA.2.75.2, BQ.1.1 and XBB) than those who received 1 or 2 monovalent [original] boosters" https://t.co/5m6Pmahli3 https://t.co/zuiyGWmAfC

2022-12-21 20:29:50 Coverage of this report https://t.co/GqUy6rIxLR by @dmosbergen https://t.co/XWUK5aLNWn

2022-12-21 19:18:05 A step towards improving potency of immune response for RSV vaccines. Stabilizing the pre-fusion conformation, as used in many Covid vaccines @ScienceTM https://t.co/CxDiDh0j24 @RuckwardtTracy @lauren_a_chang @NIAIDNews https://t.co/eWzSsA9DTo https://t.co/ayEPSvIUqh

2022-12-21 19:00:03 Why do some people have persistent loss of smell post-Covid? A biopsy-based study shows durable T-cell mediated inflammation long after the virus is cleared from tissue @ScienceTM by @goldstein_brad and colleagues https://t.co/5iG5ZaCtTX https://t.co/u56zCWlIGF

2022-12-21 16:13:28 New @Nature A significant discovery underpinning glioblastoma, a deadly brain cancer, involving an epigenetic target (BRD8) that blocks P53's guardian function https://t.co/N9rVOz9WkR by @CSHL @SunSherine @olaf_klingbeil and colleagues https://t.co/sEeQJZNOF3

2022-12-21 15:17:46 in today's NYT https://t.co/WP0LxOVR0X @Emily_Baum https://t.co/b39VTSo60o

2022-12-21 01:51:34 RT @elonmusk: I will resign as CEO as soon as I find someone foolish enough to take the job! After that, I will just run the software &

2022-12-20 23:47:39 The Framingham Risk Score for heart disease originated 25 years ago. Today @TheLancet a new holistic score/model was tested and validated in 2 large biobanks https://t.co/Bs1lnkrnTE @DoGenetics @IainSForrest @IcahnMountSinai @OmegaPetrazzini #AI https://t.co/ya5HqCP2Bg

2022-12-20 23:23:09 Repeated exposures to Covid or vaccines have little impact on spike-specific T cells in the circulation, in contrast to antibodies https://t.co/VYo9oo5m5h (does not address T cell breadth, homing, or durability) by @virusmonologues and colleagues @UCT_news https://t.co/W30IcpHUZF

2022-12-20 22:30:05 @drjorgemd No

2022-12-20 22:02:17 @SworldWilly @OurWorldInData Tell me about it https://t.co/sVhhbOMWfh

2022-12-20 21:40:15 For the "it's a cold" and "the pandemic is over" folks https://t.co/mzIAinl8LS

2022-12-20 21:24:19 Twitter turmoil and its influence on science https://t.co/qMgq0m0SOx w/ @CT_Bergstrom @trishgreenhalgh @OdedRechavi @RodrigoCostas1 @dsquintana @siggs28 @BristOliver

2022-12-20 19:43:42 @T_Brautigan @eBioMedicine @FelicityLiew @ShubhaTalwar @VirusesImmunity @SciImmunology No science? Goodbye.

2022-12-20 19:35:21 RT @p_openshaw: Thanks @EricTopol for flagging our study- big collaborative effort by @CCPUKstudy and especially @FelicityLiew ,@InThwaiteI…

2022-12-20 18:51:17 A stroke that emanates from the left atrium doesn't require atrial fibrillation. A prospective study of atrial cardiopathy https://t.co/uAHcz5NiIP https://t.co/HcU3TIF5IP @AnnalsofIM @faye_epi @EmeliaBenjamin @darae_ko https://t.co/gyIQZobreX

2022-12-20 17:56:29 I recently reviewed the new breakthrough obesity drugs https://t.co/SMZO20ExDk A new @PostHealthSci piece by @lauriemcginley2 and @LennyMBernstein hits on many useful, practical points https://t.co/eZDN44geuu https://t.co/UgA2gG4ZLe

2022-12-20 17:11:25 A good sign. France, the 1st country to face the BQ.1.1 variant dominance, and the US, were running neck and neck for Covid hospital admissions. Now they're diverging and France is in descent for cases. @OurWorldInData https://t.co/Gl7UoLZ6AX

2022-12-20 16:53:34 We keep evolving.... "A more expansive view of the functional potential of the human genome... embraces these hard-to-detect, small, but significant proteins that show no traces of conservation." https://t.co/SBgKjQZlsQ @CellReports https://t.co/79md3Qm4bo

2022-12-20 16:47:58 @T_Brautigan @eBioMedicine @FelicityLiew @ShubhaTalwar Maybe you should read about it, like the piece I wrote with @VirusesImmunity @SciImmunology, before sending DON'T replies. #SARSCoV2 ≠ flu. https://t.co/OujfFxMgU6 https://t.co/KdVRVVp5fM

2022-12-20 16:25:13 We just learned a lot more on the genomics of colon cancer. A multi-omics approach in over 100,000 cases shows association cumulatively up to 73% of familial risk @NatureGenet @fredhutch and global collaborators https://t.co/mguJS3KpAj https://t.co/KxwMkFL8nU

2022-12-20 15:29:01 New @ScienceMagazine Following Covid, MIS-C, the rare and potentially lethal multisystem inflammatory syndrome in children, has been elusive for its biologic basis. Today a report of 5 unrelated kids with genetic OAS-RNase L deficiencies https://t.co/LHgIlLeMIS Link needs fixing https://t.co/V1CguLr844

2022-12-20 15:07:06 RT @ScienceMagazine: The authors of “Gradual emergence followed by exponential spread of the SARS-CoV-2 Omicron variant in Africa” are retr…

2022-12-20 01:34:38 The Figure tells the story https://t.co/cqKaP7J4J3

2022-12-20 01:26:34 Why we desperately need nasal vaccines to block infections and reinfections https://t.co/hzYDvrq34M @eBioMedicine by @FelicityLiew @ShubhaTalwar and colleagues https://t.co/G3nJiGwiSz

2022-12-19 20:22:34 RT @kmpanthagani: You may have heard the shocking headline that 250,000 people die every year in the US due to misdiagnosis in the ER. You…

2022-12-19 20:15:30 The 1st drug to show efficacy vs NASH (nonalcoholic steatohepatitis) in a Phase 3 randomized trial after a long run of negative trials https://t.co/8tsaLo35r7 https://t.co/A4teHc8M84 https://t.co/Lr3iBlbPKK

2022-12-19 17:10:59 Rapid sequencing of blood or relevant body fluids can identify the root cause of serious infections and help guide therapy (in less than 8 hours), but, with rare exceptions, it isn't being done. Now ~9 years after proof of its lifesaving capacity https://t.co/Hr6AVrNBRB https://t.co/Sy8UUXWIQo

2022-12-19 16:51:05 The tonsils and adenoids of children who have had Covid have persistent tissue-specific immunity which includes antigen-specific memory B and T cells https://t.co/fxTpLKz1oU @NatImmunol by @ManthiramMD and colleagues @NIAIDNews https://t.co/dkxB458zgt

2022-12-19 16:31:50 The diverse prospects for nanomedicine to tackle Covid-induced clotting and related inflammation https://t.co/b6TNXIFHaZ @NatureNano @peijerussell @NicoVoelcker @MIPS_Australia https://t.co/25DyKFvYvG

2022-12-18 19:26:35 Good explainer for what I think was the most interesting paper last week @ScienceMagazine https://t.co/hIgBViXMaJ https://t.co/t4a8zLNt8P

2022-12-18 19:03:35 Link to graph https://t.co/Cze8bZxwXr Link to 94% of people age 65+ had 2 shots and only 36% have had a recent booster https://t.co/WWoVjw5Bll Link to the new data on booster impact reduction of hospitalization age 65+ https://t.co/sAxR8IxKgr

2022-12-18 19:00:07 The US "senior wave" of Covid hospitalizations has already exceeded the summer BA.5 wave and may soon surpass the Delta wave. Most of these admissions could have been prevented with a booster shot. https://t.co/plG8BngKxy

2022-12-18 18:49:44 @billbrown Historically yes. Both those challenges have now been squarely addressed in thousands of such diagnosed patients with costs of desktop sequencing and reagents not a barrier. Think about the cost of 1 day in the ICU

2022-12-18 18:41:18 @nanopore @GSTTnhs Thanks @nanopore. I forgot about that paper (even though I posted it at the time it was published last year). I've revised the substack to include it and appreciate all you're doing to make clinical metagenomics the standard of care

2022-12-18 16:28:20 Rapid sequencing of a person's blood or relevant body fluid can determine the root cause of a serious infection. Why isn't this standard medical practice?https://t.co/Y8eZSBaTZI https://t.co/dFklQ7Y4Yg

2022-12-18 01:43:22 @alexmeshkin @WHCOVIDResponse February 2023

2022-12-18 01:40:48 Impressed. Ordered 15 Dec

2022-12-17 22:32:50 @mdhhsu I did

2022-12-17 22:15:11 Why don't we use rapid sequencing (metagenomics) to identify the cause of sepsis? https://t.co/Y8eZSBaTZI

2022-12-17 16:08:09 When you consider that much of the new data on bivalent booster protection is based on comparison with people who have had multiple shots and boosters, and infections, it's particularly impressive https://t.co/sAxR8IxKgr

2022-12-17 16:03:32 Sorry, that's @fmanjoo

2022-12-17 15:57:56 @Veinless @kyle_minogue @CDCMMWR The BA.5 bivalent, the only bivalent in the US

2022-12-17 15:56:05 This is really well done, by both @manjoo and #ChatGPT https://t.co/2StExLekaE @nytopinion https://t.co/fM7K6sgMwM

2022-12-17 15:39:36 The tripledemic #dataviz https://t.co/aR5bQXSeFE by @amyswalk @nytgraphics https://t.co/eivKuuoyao

2022-12-16 22:02:25 @cwarden19 Thanks for your reply. I’ve put a clarification about the comparator group and context with prior reports

2022-12-16 21:59:25 Clarification: this study compares vaccine-induced myocarditis with viral myocarditis (not Covid). There are several other reports that I’ve previously posted w/ direct comparison with Covid myocarditis

2022-12-16 21:48:00 RT @thehowie: "If you want to give a great holiday gift to any and all seniors you know, that could be life-saving or prevent a hospitaliza…

2022-12-16 21:19:48 The natural history of vaccine-induced myocarditis for outcomes such as heart failure, dilated cardiomyopathy, or death is far different—more favorable—than from Covid myocarditis (besides the latter being considerably more common) https://t.co/2de1Eth12N https://t.co/UKOMRKYNt0

2022-12-16 20:27:19 Where is the new @NIH Director with Francis Collins having stepped down a year ago? @hholdenthorp is on it https://t.co/WtwrtcHIi7 @ScienceMagazine https://t.co/fLHV76Sufz

2022-12-16 20:15:30 Here's my quick update for what we now know about the bivalent booster impact on outcomes https://t.co/sAxR8IxKgr

2022-12-16 18:53:14 Until now the immune escape of BQ.1.1 and XBB has been largely (if not exclusively) assessed via neutralizing antibodies. Here are new (in silico data): the T cell responses (CD4+, CD8+) are likely intact vs these variants, which helps prevent severe Covid https://t.co/j2ycDYFtU1

2022-12-16 18:24:31 Here are the new data for the bivalent booster for all ages vs emergency room and urgent care visits https://t.co/tedNCNoYV2 https://t.co/Fpzo6UoiQi

2022-12-16 18:07:42 Yet 64% of seniors in the US have not had a recent booster https://t.co/WWoVjw5Bll And seniors account for nearly all of the rise of Covid hospitalizations https://t.co/Cze8bZxwXr https://t.co/OKJoCnapvr

2022-12-16 17:56:29 First look at bivalent booster vaccine effectiveness vs hospitalizations through November for age 65+ Strong protection >

2022-12-16 17:22:33 The new, potent anti-obesity drugs have impact beyond reducing obesity https://t.co/v0YRKWjZXa @NatureRevEndo I reviewed in some depth here https://t.co/SMZO20ExDk https://t.co/vbujFvTU1s

2022-12-16 16:53:20 A call to action for rebooting randomized clinical trials by leading cardiologists, published in @CircAHA @JACCJournals @ESC_Journals https://t.co/DB454UYfWY particularly to use digital technologies, reduce cost, improve efficiency and speed https://t.co/R8u58iSId9

2022-12-16 15:44:13 XBB's double-digit % presence in the Northeast. https://t.co/KXVXx8r0qs

2022-12-16 15:44:12 The BQ.1 variants rise in the US to ~70%, updated today. BQ.1.1 itself (38%) is still not dominant

2022-12-16 00:22:35 Reducing symptoms and increasing activity in a small cohort of people with #LongCovid using pacing https://t.co/1uKg2x046z https://t.co/QVEAOhQsFm

2022-12-16 00:10:32 200 years after the birth of Louis Pasteur, the most visible scientist of his century "Perhaps no one better symbolizes the fundamental role of science within medicine" https://t.co/sBeQbiO3DP @TheLancet's new theme issue is rich with reviews, perspectives https://t.co/wmXbGU4s5I

2022-12-15 23:11:14 T-cell engineering vs cancer has gone to an unprecedented level for when and where cells act, via synthetic circuits @ScienceMagazine https://t.co/84Prp9xDPd https://t.co/ldH6E16bvs Good explainer @Nature https://t.co/F4ttkfQvQ1 Cellular engineering's impact is growing quickly https://t.co/6aXYNxz18I

2022-12-15 20:02:17 What's POTS? Nice demonstration by @ahandvanish https://t.co/mOD0OwLvXw

2022-12-15 19:03:30 What is @ScienceMagazine's Breakthrough of the Year? The James Webb Space Telescope Runners-up include progress in RSV vaccine, the Epstein-Barr virus associated with multiple sclerosis, foundation (creative) models #AI https://t.co/Dp0oiR2txZ https://t.co/98C8bV38WP https://t.co/hesn4Uneg6

2022-12-15 17:22:17 The primary efficacy endpoint--1-sided superiority--was pre-specified in the protocol and analysis plan https://t.co/mGhEBwwARc https://t.co/0NuF6PWi4v

2022-12-15 17:15:02 This week's editorial @Nature on Covid mortality https://t.co/3oX0TxocAX https://t.co/8rzozUQzql

2022-12-15 16:42:50 The broad benefit of SGLT2 inhibitor drugs (sodium/glucose cotransporter 2) in patients heart failure with preserved ejection fraction and symptoms https://t.co/SJsGxIedjt @NatureMedicine today

2022-12-15 15:42:36 What really matters in a crisis: experiments to explore life-and-death situations https://t.co/J9tGaV2DX0 @gordon_hecker @bengurionu https://t.co/kOAi6EP0nK

2022-12-15 15:31:36 For access https://t.co/HJWbrLS5QE

2022-12-15 02:40:58 The Elonathon by @stephanpastis https://t.co/NyMuWgUoxJ

2022-12-15 00:59:49 RT @EricTopol: We've never had medications that can safely achieve ≥20% body weight loss. With over 1 billion people with obesity and >

2022-12-15 00:37:15 Returning to free Covid tests in the US . They'll come in handy with upcoming gatherings, especially with the current wave gaining steam. Ordering starts tomorrow https://t.co/t7GnkZ8Qva

2022-12-14 21:43:32 "Loss of smell and taste during COVID-19 infection are strong predictive factors for a robust immunologic response based on IgG [antibody] titers" https://t.co/2sbGdI1R2G @PLOSOne @ColumbiaOto @ColumbiaMed

2022-12-14 21:23:18 Can an intermittent fasting (IF) diet reverse Type 2 diabetes? A small randomized trial says yes, w/ 47% of IF-assigned participants achieving remission for at least 1 year vs 3% of controls (odds ratio of 31

2022-12-14 21:11:55 All is not quiet on the Asian-Pacific front (besides China) https://t.co/ON6Xhw2DvP

2022-12-14 20:48:39 @LisaAMcCorkell @Nature @yunlong_cao I feel so lucky to have worked with you, @ahandvanish, and @julialmv on the soon to be published #LongCovid review paper in a @NaturePortfolio journal

2022-12-14 20:24:24 @yunlong_cao @Nature @LisaAMcCorkell We are all deeply appreciative of the fine work that you and your colleagues have done to extensively characterize #SARSCoV2 variants , and published the data, well before they declare themselves clinically

2022-12-14 19:04:08 RT @bel10: This is a really positive, hopeful read if you need one today. Actual lasting silver linings of this pandemic have been few and…

2022-12-14 18:48:52 This is what not protecting seniors results in.... Add the BQ.1.1 variant to under-boosting, lack of mitigation factors On the way to exceeding BA.5 variant wave peak https://t.co/axTWPiQjNE

2022-12-14 18:29:58 Impressive work by @Lenka_Dohnal @nitaidean @sellmyerlab @FitzGerald__Lab @PSUmetabolomics @BaurLab @AmberAlhadeff @Helfrich_lab @MaayanLevy_Lab See thread by @ThaissLab Hope they have a @redcube link for those with access issues https://t.co/5G7ByqA1Q5 https://t.co/4XutRKAqmo

2022-12-14 18:20:13 RT @alexnatarosMD: Excellent synopsis of @elonmusk-era #MedTwitter @CMAJ Highlights MDs to “counter &

2022-12-14 18:09:15 Among @Nature's Top 10 people who shaped science in 2022, big congratulations to @yunlong_cao Covid predictor and @LisaAMcCorkell #LongCovid advocate https://t.co/i7KcjWRQMy https://t.co/AMGURebvvy

2022-12-14 16:53:06 "My gut microbiome made me do it" "What?" "Exercise" https://t.co/Ntys1n6RX4 @Nature by @ThaissLab @ChristophThaiss @PennMicro @PennMedicine https://t.co/k3WdHmjOFM @NatureNV @pipethero @GulistanAgirman @UCL @justsaysinmice https://t.co/ijfXtwzcMD

2022-12-14 16:40:47 The deaths from Covid in the first 2 years of the pandemic were nearly 3-fold reported—~15 million globally—by @WHO excess death calculations https://t.co/YwZHD4ufC1 @Nature https://t.co/sE7wVs0tWR

2022-12-14 16:31:57 The distribution and persistence of #SARSCoV2 throughout the body and brain in people who died from Covid https://t.co/plsFOl1QYM @Nature https://t.co/pO8DX3G2jQ

2022-12-14 15:32:28 PML (progressive multifocal leukoencephalopathy) is a rare, dreaded and often fatal brain infection that can occur after immunosuppressant drugs. The potential for screening gene variants to avoid PML is raised here https://t.co/XN9MjUU0Ds https://t.co/CtZSXWtPDa

2022-12-14 15:17:44 Just published @CellCellPress "Alarming antibody evasion properties of rising #SARSCoV2 BQ and XBB subvariants" These are the current US variants to reckon with. Were it not for the immunity wall that's been built, we'd be having a much rougher go at it https://t.co/VqxKpU5ZKu https://t.co/3WjcHL7jPB

2022-12-14 01:30:24 My review of where this is headed, well beyond infectious diseases and cancer. Real pluripotent potential https://t.co/6l2aW15kRF https://t.co/eVrOaQuPXB

2022-12-14 01:26:34 In just 3 weeks using the mRNA platform we've seen: —a universal flu vaccine effective in multiple experimental models https://t.co/CfABwulTzS —1st sign of efficacy in a cancer randomized trial (vs Stage 3/4 melanoma) https://t.co/KtwPrwq9oO https://t.co/LEmljWiqbd

2022-12-13 18:59:15 The ongoing Covid "senior wave" in the United States, already has surpassed the BA.2, BA.5, and soon Delta waves for hospital admissions among people age 70+ https://t.co/Cze8bZxwXr Most admitted have had 2 shots but w/o a booster in >

2022-12-13 15:30:49 Debunking myths on metabolism and daily energy expenditure, especially with respect to age https://t.co/9KQ5IjvpEs by @HermanPontzer @sciam https://t.co/1NhTVcctN9

2022-12-13 14:32:57 @HelenBranswell @WHO @JeremyFarrar @wellcometrust Yes, this is big news. Congratulations @JeremyFarrar for your new post! And to @WHO for recruiting him

2022-12-13 14:15:34 More on this here, by @matthewherper @statnews https://t.co/KtwPrw8yxg and https://t.co/VIbuOauW3Z @FT @JamieSmythF https://t.co/ur9GsUguB9

2022-12-13 12:09:00 The 1st randomized trial of an mRNA cancer vaccine to show efficacy: Stage III/IV melanoma, a combination immunotherapy + vaccine was superior to immunotherapy alone for recurrence-free survival. 157 participants (Phase 2b) w/ large trial planned PR by Moderna &

2022-12-13 02:14:16 RT @FutureDocs: @EricTopol it’s like he wants us all to go but we should not comply

2022-12-13 01:57:06 If the #ScienceTwitter &

2022-12-13 00:09:49 For people with Type 2 diabetes, an open-label randomized trial of a low carb, high fat diet vs hi carb, low fat showed substantial benefits for 6 months that were not sustained during follow-up https://t.co/VsqmlejcE1 @AnnalsofIM @AleksanderKrag @Camilla_Dalby https://t.co/NzN4JyxBHY

2022-12-12 23:52:08 France has withstood the challenge of the BQ.1.1 variant fairly well as the 1st country to see it achieve dominance, an encouraging sign relative to its immune evasiveness @OurWorldInData and https://t.co/kraBgpXvtv https://t.co/LYAzvwikiI

2022-12-12 23:22:10 Significant reduction of hospitalization (by 40%) and deaths (by 70%) among patients who received Paxlovid vs controls in a large US health system (@MassGenBrigham) https://t.co/adjB62nooJ @AnnalsofIM @AnnWoolleyMD @SDrydenPeterson https://t.co/m1NgJXAvBI

2022-12-12 19:46:22 Part of the explanation for why there's a lot of variability for neutralizing antibodies after Covid: genomic variants in the imunoglobulin heavy chain https://t.co/UUvqfOrbfh @ImmunityCP https://t.co/dLm7N5ktWi

2022-12-12 16:50:55 RT @EricTopol: I wrote about the new anti-obesity drugs—semaglutide (Wegovy) and tirzepatide (Mounjaro)—that represent one of the most impo…

2022-12-12 16:47:56 Accompanying editorial by @dysclinic and @ArturFedorowski https://t.co/20gmj51uxv https://t.co/Q9ZFjTBKqR

2022-12-12 16:33:54 Postural orthostatic tachycardia syndrome (POTS) can occur after Covid and in the 90-day period following vaccination. It is 5-fold more common with infection https://t.co/MYMYvt1sOJ @NatureCVR @CedarsSinai https://t.co/PR390ypkET

2022-12-11 20:45:18 "When it comes to protecting seniors, we’re doing a terrible job of that in this country” https://t.co/vGLtcHNLyw by @CarlaKJohnson @laura_ungar @AP @APHealthScience In many states, Covid hospitalizations for people 70+ are higher than during their BA.2 and BA.5 waves https://t.co/ptqvUcngqH

2022-12-11 18:32:11 Why are long-lived lung, tissue-resident memory T cells so important vs Covid ? https://t.co/BOBSmGZrLi @NatRevImmunol Francis Carbone @TheDohertyInst @UniMelb https://t.co/JbYAAli0mV

2022-12-11 17:47:29 We've never had medications that can safely achieve ≥20% body weight loss. With over 1 billion people with obesity and >

2022-12-11 17:08:58 My friend, @UrnovFyodor, a pioneer of genome editing, lays out his vision and deep concerns about "word-processer- like control over DNA" "The invention of CRISPR gene editing gave us remarkable treatment powers, yet no one should do a victory lap." https://t.co/49OwXvP7kg https://t.co/3RV3I37sHl

2022-12-10 20:41:51 I wrote about the new anti-obesity drugs—semaglutide (Wegovy) and tirzepatide (Mounjaro)—that represent one of the most important breakthroughs in medicine https://t.co/SMZO20ExDk

2022-12-10 16:45:42 We're now in the era of spatial biology: it's not only possible but becoming essential to define the spatial process &

2022-12-10 16:26:05 "These observations indicate the need for development of mucosal vaccines to induce potent immune responses at sites where #SARSCoV2 infection occurs." https://t.co/OJQuUipaHi H/T @chrishendel https://t.co/tWhL61J2mu

2022-12-10 15:33:09 Just out @NEJM, a "milestone" The level of neutralizing antibodies induced by Covid vaccines has been established as a correlate of protection, i.e. a surrogate endpoint for predicting clinical outcomes and use for regulatory approvals https://t.co/CLMoASrRnt https://t.co/ZBIIb9rFsM

2022-12-09 18:36:00 RT @davelevitan: Just because this tool is pulling from millions of peer-reviewed papers doesn't make its conclusions true or good. "You…

2022-12-09 18:22:21 Case report of 2 individuals with #SARSCoV2 remnants in penile tissue at 1 month after Covid https://t.co/dYUfJjKQdL https://t.co/3hhgIC1hjJ

2022-12-09 17:27:56 In the same time frame September to now, look at booster uptake in England among 65+ seniors (>

2022-12-09 16:37:30 The GATTACA film 25 years later Its "prescient forewarnings are still relevant today in light of the current trajectory of genomic science and technology." by @dovgreenbaum and @MarkGerstein @NatureGenet https://t.co/0jBNjgwaTP https://t.co/kpn25pUOIN

2022-12-09 16:23:39 —90% of Covid deaths in the US are now in people age 65+ —94% of Americans age 65+ have had 2 shots, but majority with no booster, only 34% with bivalent booster https://t.co/5wOCpbxZO1 @dwallacewells @nytopinion

2022-12-09 15:41:12 Some regional variability for BQ.1.1 https://t.co/qJCk7AaoJ2

2022-12-09 15:41:11 The BQ.1 variants taking over, now ~70% in the US with the BQ.1.1 37%

2022-12-09 04:46:21 @msb1iop @paulg @NatureMedicine @ma_hamer @M_Stamatakis Thanks. I didn't delete anything

2022-12-08 22:03:27 China's elders problem https://t.co/3TcJQYrFul https://t.co/uG4zedUfuK

2022-12-08 21:43:12 Comparison of ChatGPT and AlphaCode https://t.co/QjlEMViyOT

2022-12-08 21:41:13 @richardludlow @NatureMedicine @ma_hamer @M_Stamatakis No cause and effect established or asserted

2022-12-08 19:46:05 RT @hholdenthorp: Enjoyed talking to Tony Fauci about the last few years and what lies ahead. Lots of great stuff in here for science polic…

2022-12-08 19:22:32 No problem, I'll code for you #AlphaCode https://t.co/7m41MgwHUM "This result marks the 1st time an #AI system has performed competitively in programming competitions" @DeepMind @OriolVinyalsML Not so fast. What it can and can't do. https://t.co/lasA1mJK08 by @zicokolter https://t.co/QqRYL14VJh

2022-12-08 18:40:15 Why does having a human cell atlas, with single-cell and spatial definition, have such transformative potential in medicine? https://t.co/l1II0q1was by @jennyErood @AidMaart @teichlab @GraphicAnja Aviv Regev @NatureMedicine https://t.co/0ZSvKnYaMg

2022-12-08 18:29:52 @JeremyKonyndyk Thanks Jeremy!

2022-12-08 17:36:09 1 vs 3 , a 3-fer https://t.co/ik98DuHT76 by @AlexLJanin w/ @dr_kkjetelina https://t.co/jZnusaUtxA @taraparkerpope @FenitN https://t.co/MyRvFSqD2G

2022-12-08 16:51:44 The conclusion is worth reviewing —1 minute bursts, 3 to 4 per day —for non-exercisers, there's hope —these finding only possible via ~25,000 people from @uk_biobank, wearable sensors, and #AI analytics —1st research to measure VILPA effects https://t.co/ECoOUmaaOo

2022-12-08 16:45:19 @paulg @NatureMedicine @ma_hamer @M_Stamatakis Yes, correct. 1 minute bursts made a difference, 3-4 per of these per day associated with the protection

2022-12-08 16:34:59 Vigorous intermittent lifestyle physical activity (VILPA), 3-4 minute bursts per day, associated with ~40% reduction of all-cause mortality, cancer and cardiovascular mortality https://t.co/BoGmigjqWl @NatureMedicine @ma_hamer @M_Stamatakis https://t.co/UPx61oh4Gs

2022-12-08 16:19:41 Subsequent development of #LongCovid detected by gene expression during acute infection. Two different patterns related to antibody production to spike protein https://t.co/ZklAmwyk4L @NatureMedicine @noambeckmann1 @IcahnMountSinai https://t.co/7uklWADq7e

2022-12-08 15:18:00 RT @Yale: PODCAST: @thehowie and @hmkyale are joined by Dr. Eric Topol, a physician and writer to discuss his career turn toward genomics a…

2022-12-08 13:00:00 CAFIAC FIX

2022-12-07 08:00:00 CAFIAC FIX

2022-11-13 23:12:39 @DrAhmedKalebi @washingtonpost Hope so!

2022-11-13 22:29:15 RT @pnatarajanmd: .@EricTopol discusses the exciting advances in more cost-efficient timely clinical while genome sequencing. Uniquely, the…

2022-11-13 21:11:24 @DeAnnGlobalHea1 @washingtonpost @PostOpinions I do the best that I can with the data that are (or when they are) availablehttps://t.co/DzBiZvrXBN

2022-11-13 21:06:43 I'm getting criticized for not highlighting more parts of the editorial. Here's the updated highlighted version https://t.co/zMgnTgISos

2022-11-13 20:54:07 I liked Michael Lewis's book a lot more https://t.co/QtrUJzxjlf

2022-11-13 20:30:13 Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so much attention has been on the lowering of cost, [sample ->

2022-11-13 17:03:30 @Mssarahmssarah @washingtonpost @PostOpinions Sure. I could have highlighted every word—it was that good

2022-11-13 16:51:54 Thanks for the mention/linkhttps://t.co/yEQ6h5f4KW

2022-11-13 16:51:53 Excellent, pitch perfect editorial on the new variants and current status of the pandemic, by @washingtonpost editorial board todayhttps://t.co/zdU2fPCTpJ @PostOpinions https://t.co/CmrSN3RsyW

2022-11-13 15:35:13 My friend @LCalabreseDO, a leading rheumatologist, relates his own experience with #LongCovidhttps://t.co/spHlV61gAg @HealioRheum https://t.co/dpqnJ7Gi5X

2022-11-13 02:17:15 Nevada. Winner Catherine-Cortez MastoSenate retained control to Democrats just now

2022-11-12 23:37:46 @nlj @OurWorldInData That's right and I stand by it. If Omicron had not arrived, the pandemic would have been over after Delta.My statement was very clear: "If there's not a worse than Delta...." And there was. Period.

2022-11-12 23:32:57 The same applies to excess mortality for the world.Yet so many people are unreceptive to any good news https://t.co/6X15RMUv0W

2022-11-12 17:44:15 Another review of @DrSidMukherjee's Song of the Cell, one of the best books this year@nytimesbooks by @jenszalai https://t.co/yLFzOpT539 https://t.co/NUGLG1FEEB https://t.co/iyHkq6644o

2022-11-12 16:18:29 Good to seeNear pandemic low and trending lower by log-plot@OurWorldInData https://t.co/zENBw9dnAW

2022-11-12 16:03:21 Covid has been associated with an increased risk of both Type 1 (autoimmune) and Type 2 diabetes, but there are many unresolved questions. A good perspective piece @NatMetabolism https://t.co/d1cnHGukq8 https://t.co/3bYG7uLvPz

2022-11-11 23:06:07 @chrischirp good to see this!

2022-11-11 17:43:13 @mlipsitch Agree with your point, Marc, but disagree that vaccines provide adequate/durable protection vs symptomatic (re-)infections. That was true through Delta but there's been marked erosion of that protection since Omicron in late 2021 and its descendants

2022-11-11 16:57:58 What is encouraging is that New York State, the highest BQ.1.1% in the US still shows no sign of increased Covid hospitalizations. Same for the US overall https://t.co/fGkw5lysLP

2022-11-11 16:49:00 A simplified map of human metabolic pathways

2022-11-11 15:55:31 New US Covid genomics: the BQ.1 variants have risen to account for 44% of cases, with BQ.1.1 at 24% (18% a week ago), as BA.5 rapidly fades. BN.1 shows some increasehttps://t.co/jjl2AnOYb5 https://t.co/94vLZ04aXA

2022-11-11 15:25:02 A new first-rate review of how the mRNA-nanoparticle platform is moving in clinical trials of infectious diseases, cancer, protein therapy and genome editing. And the many innovations in storehttps://t.co/esvgsHWF9y @NatureMedicine https://t.co/F2gYQgMRrL

2022-11-11 15:04:07 RT @EricTopol: The daily pandemic briefing Ground Truths today is on 2 publications regarding Covid reinfections and #LongCovid https://t.…

2022-11-11 02:58:10 @ValdaVinson @hholdenthorp @oooitsplasma @hoelza She’s the best life science graphic artist!

2022-11-11 01:31:36 The daily pandemic briefing Ground Truths today is on 2 publications regarding Covid reinfections and #LongCovid https://t.co/QyJtagZamT

2022-11-10 23:00:44 RT @larrybrilliant: No one knows if this winter will see a surge, a wave, or a flat and even decreasing level of cases and deaths from COV…

2022-11-10 22:32:39 New @SciImmunology —Covid vaccines neutralizing activity is almost entirely to S1 subunit of the spike—2-P substitution works well to nAbs, 6-P would likely be better—Better vaccines can and should be madehttps://t.co/u0TBY4KXBU by @veeslerlab

2022-11-10 22:23:33 The best review of tissue macrophage cells—critical for both preserving health and their role in many diseases—that I've seenhttps://t.co/5brtq516qI @CellCellPress @MiriamMerad @SinaiImmunol @park_mstreet @AymericSilvin @FGinhoux @SinaiMSTP https://t.co/FetlDBc74X

2022-11-10 19:24:51 New report from Germany of a large matched-control #LongCovid study of 157,000 people w/Covid, including ~12,000 children and adolescents"The results of the present study indicate that post-Covid-19 cannot be dismissed among children and adolescents."https://t.co/JvNgibLw21 https://t.co/sryOmAY4uI

2022-11-10 18:07:18 RT @EricTopol: Today's Ground Truths, pandemic briefing, on booster waning, brain fog with #LongCovid, and potential of Paxlovid resistance…

2022-11-10 18:00:58 Documenting #SARSCoV2 evolution in deer and a deer-to-human transmissionhttps://t.co/jlMwOcIvOj @NatureMicrobiol by @jeffcbowman @SMubareka and colleagues @UofTEPIC @UofT

2022-11-10 16:58:19 Vaccine status was not protective vs reinfection sequelae, which is why we need nasal vaccines to achieve mucosal immunity, limit infections, reinfections, and spread. Since the arrival of Omicron, we've seen limited (effectiveness &

2022-11-10 16:38:34 Just published @Nature 1st #CRISPR genome editing of immune T-cells to treat cancer, individualized for 16 patients with solid tumors, with some successhttps://t.co/vaAtFm43nbhttps://t.co/HFaQLyi6rkby @heidiledford https://t.co/ymkxkx6HaS

2022-11-10 16:16:36 All-cause mortality, hospitalizations and adverse sequelae are increased by reinfection, not just in the acute phase but during 6 month follow up https://t.co/6Uulb3fxGa

2022-11-10 16:16:34 Graphic of adverse outcomes by number of infections, a dose-response relationship https://t.co/mmM9zA9sn5

2022-11-10 16:11:29 Covid reinfections are bad for your health. Big @DeptVetAffairs study published @NatureMedicine today. #LongCovidhttps://t.co/1ZMbAnolSiby @zalaly and colleagues https://t.co/OXD2uGpVZ1

2022-11-10 01:43:56 Today's Ground Truths, pandemic briefing, on booster waning, brain fog with #LongCovid, and potential of Paxlovid resistancehttps://t.co/qMi0fhXEOJ

2022-11-10 00:36:28 The 4th shot (2nd booster) induced a good, sustained neutralizing antibody response but its protection vs infection was less durable (lasting ~3 months) than the 3rd shothttps://t.co/6sAPJvJAR6 @NEJM https://t.co/TavoVpkfVb

2022-11-09 22:27:52 The mechanism of brain fog with #LongCovid (and potential biomarker, CCL11) after a mild casehttps://t.co/8k2O8EA3xn @VarunVenkatara2 https://t.co/webMwfeVzF @CellCellPress @Franklandlab https://t.co/NQAgabJntg

2022-11-09 22:18:35 Evidence for benefit of masking in schools when the universal policy was rescindedhttps://t.co/c2evJWVm5v @NEJM @ToriCowger @KTHallPhDMPHeditorial https://t.co/WBm16es4gj by @JuliaRaifman @Tiffany_L_Green https://t.co/R7Wv10jxWM

2022-11-09 22:06:28 A triumph of successful in utero (fetal) treatment of Pompe's disease, a rare fatal genetic conditionhttps://t.co/5W1UdBbI78 @NEJM https://t.co/uZjb9Wt3U4

2022-11-09 19:20:00 3 important #cancer papers today1. Spatial genomicshttps://t.co/sr50tvUYac@nature2. Cancer vaccineshttps://t.co/37L9NSzrYr @ScienceTM3. Engineering immune cells (CAR-T) for Rxhttps://t.co/syPpYN8lUr @ScienceTM https://t.co/FvAr8lfWKX

2022-11-09 18:11:39 "We thus identified a recovery-organizing neuronal subpopulation that is necessary and sufficient to regain walking after paralysis"Restoration of walking capability in 9 patients with spinal cord injuryhttps://t.co/Jr8FepTreohttps://t.co/1tsvSyfQH6@Nature @EPFL_en @gcourtine https://t.co/Fm8xtZag3V

2022-11-09 16:37:42 Can Calmodulin gene variants exonerate "Australia's worst female serial killer"?https://t.co/IipS3z4oRO@nature by @nickyphillips_ https://t.co/6owJ75e6f0

2022-11-09 16:27:41 In pregnancy, a 10-fold higher #SARSCoV2 antibody from vaccine compared with Covid infections and enhanced protection for the newbornhttps://t.co/5Q3xzq6Q4Q @JAMANetworkOpen @dus10flan @ChildrensPhila @karen_puopolo @PennMedicine

2022-11-09 15:43:51 A new review of how mRNA vaccines work and the multiple ways the mRNA-nanoparticle platform can be improved to be more effective with less side effects (that is hardly being pursued)https://t.co/Wik2hH2pLN @ImmunityCP by @rein_verbeke and colleagues https://t.co/qXIjXzYOnd

2022-11-09 04:13:35 Polls. Schmolls.Again

2022-11-09 03:09:53 RT @mehdirhasan: Covid didn’t even get a mention in these midterms. Absolutely crazy.

2022-11-08 22:08:53 https://t.co/wbWEtix2s5

2022-11-08 19:03:24 @Agtgtwn Many thanks!

2022-11-08 18:53:36 @bbdd333 yes https://t.co/2dcaYJqbVF

2022-11-08 18:51:13 RT @jrfunke: Good news: "This uncoupling of lab assays of immune escape vs a benign clinical outlook is the first we have seen in the pande…

2022-11-08 16:51:04 RT @EricTopol: The reasons I think it's essential for #ScienceTwitter and #MedTwitter to stay with @Twitter right now—Spread the truth/fac…

2022-11-08 16:28:55 A brilliant review of the role of immunity in Alzheimer's disease and its potential as a target for therapyhttps://t.co/aZXEDZVYRtby @xiaoyingchen36 @holtzman4 @WUSTLmed @ImmunityCP @WUADRC https://t.co/edCSx5kE1D

2022-11-08 15:16:05 The impact of #LongCovid on the American workforcePersistent loss of ~500,000 workers"A mass disabling event"—@Cutler_econ https://t.co/PxnX3S69nS by @sinoceros @laurenweberWSJ https://t.co/ID1GlOQVBJ

2022-11-08 14:56:54 RT @EricTopol: An optimistic outlook (with caveats)My daily pandemic briefing, #6https://t.co/yEQ6h5f4KW If you find these useful, please…

2022-11-08 05:21:07 @DrJayneMorgan Thank you!

2022-11-08 03:56:36 @rquiroga777 Noted and thanks for pointing this out. Time will tell on the BQ.1.1x

2022-11-08 03:31:45 @iaincheeseman @StearnsLab @BlaineyLab @lukebfunk @WhiteheadInst @broadinstitute @CellCellPress Sorry on the misspelling, Iain. What a remarkable resource you and your colleagues published today

2022-11-08 02:02:31 @vaccinate Much appreciated!

2022-11-08 01:55:57 An optimistic outlook (with caveats)My daily pandemic briefing, #6https://t.co/yEQ6h5f4KW If you find these useful, please subscribe and share. They are free and always will be.

2022-11-07 22:03:42 How to determine all the essential human genes?Analyze >

2022-11-07 20:39:49 The prolonged recovery of consciousness in some patients with severe Covid is unusual. The brain state and pattern resembles the painted turtle and may be protective https://t.co/nFrLle1l4L @PNASNews https://t.co/iLVbiS1m9y @NYTScience @carlzimmer https://t.co/JbtKcSa4FO

2022-11-07 17:01:39 So you want to take down all the β-coronaviruses?Yet another path to broadly neutralizing antibodies as a template for variant-proof vaccines—the stem helixhttps://t.co/NkBfjUstbz @cellhostmicrobe @NIAIDNews @scrippsresearch https://t.co/b1SiuRtmiG

2022-11-07 16:06:21 As the BQ.1.1 threat fades in France (the bellwether), it's a preliminary good omen for the holiday season that we won't be facing a major waveAdd to this: the bivalent booster induces some cross-immunity protection vs BQ.1.1 &

2022-11-07 15:09:33 RT @EricTopol: The first study to show improvement in long-term outcomes after Paxlovid—including less #LongCovid, deaths, hospitalizations…

2022-11-07 01:35:00 We haven't had a treatment for Lp(a), a well known risk factor for heart disease. We may now. https://t.co/E8TAfp5coE #AHA2022 @NEJM @DrM_ODonoghue@marcsabatine @TIMIStudyGroup @Brighamw https://t.co/hJICTPq4MQ

2022-11-07 01:27:42 @dralicehan Thank you!

2022-11-07 00:37:56 Consistent and significant reduction of #LongCovid with Paxlovid treatment across all subgroups including age, sex, race, risk factors, prior Covid, vaccination, booster, unvaccinated https://t.co/T0oGWhfaTS

2022-11-06 18:31:46 Kudos to my friend @MollyJongFast! https://t.co/qSp7S0IKkV https://t.co/5ayJzD0H7d

2022-11-06 18:23:28 @JReinerMD https://t.co/z68bDAQuhi

2022-11-06 18:07:24 The first study to show improvement in long-term outcomes after Paxlovid—including less #LongCovid, deaths, hospitalizations and complications—is a major advance. I've reviewed and contextualized it herehttps://t.co/bugfFk44sh

2022-11-06 15:31:37 The mean age of the participants in this study was 65.In the US, people age 70+ are the least likely to receive Paxlovid (missing out on acute phase benefit) https://t.co/5GuZG9BTwt

2022-11-06 14:32:46 That’s reduction (not reception)The further divergence of deaths and hospitalizations after the acute phase is notable

2022-11-06 04:23:52 @DocJeffD Thanks!

2022-11-06 04:23:27 The reception of #LongCovid and severe outcomes in the post-acute phase, associated with paxlovid treatment, was independent of vaccination, booster, prior infection or unvaccinated status https://t.co/Ivrdq4C701

2022-11-06 03:20:41 Breakdown of reduction by system and symptoms associated with Paxlovid vs controls https://t.co/4soa5duMyi

2022-11-06 03:13:37 Divergence of curves for reduction of #LongCovid https://t.co/DthdD50HMs

2022-11-06 03:06:58 Important new preprint just posted from ⁦@zalaly⁩ and colleagues

2022-11-05 17:21:53 RT @EricTopol: How #AI is transforming human embryo selection and improving in vitro fertilization. A renaissance in reproductive medicine…

2022-11-05 15:56:47 It's a good sign when you add 3 convergent mutations to BA.5's spike, have multiple lab assays showing much more antibody evasion for BQ.1.1, but we don't see any clinical sequelae (yet)Mutation map via @PeacockFlu More on this herehttps://t.co/8ikz6ZDm26 https://t.co/HUQZz3L7Y1

2022-11-05 15:20:41 Dr. Ozby @DrewSheneman https://t.co/X1ZypOJhlO

2022-11-05 01:43:11 @DennisOwen @Twitter Much appreciated

2022-11-05 01:42:01 @wudanyan Thank you!

2022-11-05 01:30:19 A note of optimism to end the weekhttps://t.co/8ikz6ZDm26

2022-11-04 23:46:49 https://t.co/fjSTg9HIvi

2022-11-04 21:14:40 @cookyscan1 @RSNA @RadiologyEditor @cekahn @luker_md @arosenkrantzmd @ReedDunnick @ruthcarlosmd @DrLindaMoy @Abbara_UTSW Thanks @DavidBluemke @RadiologyEditor @RSNA for inviting me and I throughly enjoyed our discussion

2022-11-04 21:09:30 Europe hasn't look this good for new Covid hospital admissions for some time @OurWorldInData https://t.co/4Dm88BVF5C

2022-11-04 20:41:01 Will be staying and posting @twitter for nowAlso set up here at MastodonAnd will continue posting daily (brief) pandemic updateshttps://t.co/YllXW9J82kUntil this all gets sorted out https://t.co/SWDINcV5AY

2022-11-04 17:30:04 More on current BQ.1.1 variant status and outcomes in FranceGood thread by @nicolasberrod https://t.co/kwVYa0HIlB https://t.co/swbzAWzW2S

2022-11-04 16:32:12 We now have 6 studies of the bivalent BA.5 booster->

2022-11-04 16:20:33 New York State has >

2022-11-04 16:01:28 New US CDC Covid genomicsBQ.1.1 now 19%, showing most growth advantage vs other variants (with BQ.1 combined ~35% of new cases)https://t.co/jjl2AnOYb5 https://t.co/5gecIINrcm

2022-11-04 14:34:13 How #AI is transforming human embryo selection and improving in vitro fertilization. A renaissance in reproductive medicineOur latest @TheLancet digital medicine essayw/ @MrHadiShafiee https://t.co/W2Vc7iLglB https://t.co/mIRbfRvvsR

2022-11-04 13:28:48 Here are the data presentedhttps://t.co/RRhBYPPAUsAs seen by the Table above of the 5 recent bivalent reports, importance of live virus assay needs to be underscored.Also looks good from that standpoint vs BQ.1.1 https://t.co/DpPx7zFjbs

2022-11-04 13:12:00 More on the results, why 4-fold increase is very good, augmented response seen in people age 55+https://t.co/GkKlYHJnLd by @HelenBranswell @STATnews w/ @florian_krammer (excerpt below) https://t.co/VvnxPUyv8w

2022-11-04 10:45:00 Pfizer BA.5 bivalent booster data just presented by company press release, live virus assay:Compared w/ original booster, 4-fold increase neutralizing Abs vs BA.5 at 1 month Results very similar to @SutharLab below and very encouraging https://t.co/RH2G5NZ9lL

2022-11-04 02:38:35 Even @Oprah (who made Dr. Oz's TV career) knows https://t.co/FVgH89kc27 https://t.co/UiBTCYYOUn

2022-11-04 01:54:29 Can we extrapolate the outcomes in France to the United States if BQ.1.1* proceeds here to dominance?Perhaps, but there is a major gap in vaccination and boosters favoring France https://t.co/BbZ3bkcg1h

2022-11-04 01:09:06 Correcting the Table (Shi study used a live, chimeric virus). Thanks @florian_krammer for noting https://t.co/QF6uUznCzF

2022-11-03 22:32:21 The BQ.1.1 variant's marked immune evasion in the lab is not playing out clinically to date. It is dominant (>

2022-11-03 21:27:15 Why are males predisposed to viral and vaccine-induced myocarditis?https://t.co/jJpekAAkPw @ScienceTM @SeanM_Wuvery likely steroid signaling mediated, lessons from immune-checkpoint inhibitor myocarditis https://t.co/n7pp7p3ZfI

2022-11-03 20:13:37 Special section @ScienceMagazine new issueOur interconnected brain with its ~86 billion neurons (and ~10,000 synapses with each one) when working well is a "synchronized symphony" with aesthetic featureshttps://t.co/8LEomFfvjS https://t.co/Cltl3MJSSp

2022-11-03 18:16:56 Two new reports @PLOSGenetics on genomic susceptibility or protection from severe Covid1. A risk gene (TYK2) variant for lupus is protectivehttps://t.co/lmU3YYzLDU2. 5-fold increased risk of a rare TLR7 variant https://t.co/ZWi7hf9LaB

2022-11-03 17:06:46 It has taken 3 decades and a pandemic to actualize mRNA as a therapeutic platform, and now, with attention to improving efficiency/delivery, the potential applications are remarkably broadA new outstanding reviewhttps://t.co/ta3x0ZffEm@NatureBiotech https://t.co/LUgzWijRug

2022-11-03 14:47:21 The marked propensity for blood clots with severe Covid: antibodies to platelet factor 4 likely a contributorhttps://t.co/7grOoRnJxg @PNASNews @NIAIDNews https://t.co/Tf01jttH3n

2022-11-03 03:18:43 Summary of the 5 bivalent booster reportshttps://t.co/RDydfv4MlD https://t.co/OIOmumKgDR

2022-11-03 00:56:02 In it is a summary of the now 5 bivalent booster reports that compare its immune response (neutralizing antibodies) with the original booster. And vs the BQ.1.1 variant. https://t.co/KHTtZxw0cD

2022-11-02 23:29:22 Today's brief pandemic updatehttps://t.co/RDydfuNaX3

2022-11-02 21:59:19 A 5th report on the bivalent booster vs BQ.1.1 today reinforces the high level of immune evasion of this variant, with minimal difference for the bivalent ->

2022-11-02 21:50:48 A new, fourth assessment of the BA.5 bivalent booster showed augmented neutralizing antibody response to BA.5 compared to the original, but lacking a robust response to BQ.1.1, XBB and BA.2.75.2https://t.co/HUPkDil40v https://t.co/TEmivAXvhW https://t.co/j8qBPDERG1

2022-11-02 21:05:00 Real world mRNA vaccine effectiveness in children and teens, vs Omicron infections, Qatar https://t.co/puXbEE1tDqjust published @NEJM by @HChemaitelly @Laith_AbuRaddad and colleagues https://t.co/g97JwNe9jc

2022-11-02 20:40:26 @EladSharonMD @drorsos That’s right

2022-11-02 19:42:24 How #AI can unravel cellular immunity https://t.co/H6TBbz1Mn9 @ScienceAdvances @BerendSnijder @snijderlab @BenHale89559171 @ETH_en @IMSB_ETH https://t.co/LzAj2dlWUf

2022-11-02 19:25:06 For sepsis, quantifying immune dysfunction via whole blood RNA-seq or microarray led to accurate prediction of clinical outcomes across pathogens (including Covid) and age groups https://t.co/JkRq6w6soC #AI @ScienceTM @KnightGenetics @NDMOxford @OxfordMedSci @eddiecg https://t.co/ovfe8bJh9s

2022-11-02 18:20:18 RT @GaviSeth: A great graph. We are in a renaissance of Vaccinology. I can’t wait to see what new breakthroughs science will bring!

2022-11-02 18:16:34 LinksHo https://t.co/QT5emKL881Barouchhttps://t.co/j8XNrYTaomSutharhttps://t.co/... here:https://t.co/IOVczxd0fM

2022-11-02 18:16:33 There have been 3 bivalent booster reports w/ different results. Why?—Suthar lab used live virus, others pseudovirus—There was v small advantage (vs monovalent) for BA.5 nAbs (&

2022-11-02 17:30:16 Progress: an update of @MaxCRoser's @OurWorldInData famous graph that showed the hyper-accelerated Covid vaccine success, but many pathogens without a vaccine. Good news now for RSV (1st identified in 1956) and others with promising clinical trial data () https://t.co/6k9cy0vygd

2022-11-02 16:25:06 Impact of the rollout of an inhalable Covid vaccine in Chinahttps://t.co/okFulwr2Fr @FT @cansinobio_inc by @EleanorOlcott @WillLangley96 Yet nasal or oral vaccines get no priority or dedicated funding in the United States https://t.co/9ew7dS5X1G

2022-11-02 16:11:22 This reflect the immune evasion posed by BA.5 and replicates a few previous reports, such as this one (for age 18+).Also reinforces the waning immunity over time and reliance on boosters to maintain high level of protection https://t.co/J4fXDu3AaI

2022-11-02 16:01:58 Within the United States, the BQ.1.1 variant is highest in New York (not dominant yet), so this is good to seehttps://t.co/CbsSRbB6mz https://t.co/2NGiKfvZzn

2022-11-02 14:42:10 The new data for the bivalent booster's broadening of immune response against the BQ.1.1 variant, summarized, in context with a new paper that frames the impact of boostershttps://t.co/IOVczxuB7k

2022-11-02 14:34:31 Condensates, the peculiar shape-shifting blob droplets inside cells, are being targeted for cancer and neurodegenerative diseases, among other conditionsA @Nature feature by @ElieDolgin https://t.co/1PZA3EnSbH https://t.co/pneNmUUwrl

2022-11-02 14:27:21 Confirmation of some loss of protection of vaccines/boosters vs hospitalizations and deaths in the BA.5 wave, age 50+, Ontario, Canadahttps://t.co/ycnwmaDveZ @DrJeffKwong @ICESOntario @PublicHealthON @UofT https://t.co/PyMY7YR2eU

2022-11-02 01:20:32 @SuzBrockmann Thank you!

2022-11-01 23:18:59 @SolliesSurgery Read on

2022-11-01 22:41:32 Here's my Ground Truths daily/frequent brief pandemic update for todayhttps://t.co/IOVczxdy5kIt's free. Subscriptions tell me that it's helpful.

2022-11-01 22:11:53 Some good news for the BA.5 bivalent booster Immune response protection vs BQ.1.1 and BA.2.75.2https://t.co/t08KNiBCKY @SutharLab live virus neutralization assay indicates broadened humoral immunity vs new Omicron subvariants (and neutralization >

2022-11-01 19:57:33 RT @ScrippsRTI: “With so many millions of people impaired, the need for accelerating clinical trials with promising immune-system-modulatin…

2022-11-01 18:49:35 I can remember the days when $1 billion/year for a pharma product was considered a blockbuster. Now Pfizer has 2—$34 billion for vaccines and $22 billion for Paxlovid—and they're markedly raising prices of the former "to offset weaker demand"https://t.co/aiCcxGPbtj @JamieSmythF https://t.co/GDoIKVARxS

2022-11-01 18:03:03 @LieslMcconchie @NatureComms @Lucie_Bernard_R @CadwellLab @YaleIBIO @VirusesImmunity Thanks. I plan to briefly cover that topic in my daily update later today https://t.co/YllXWa0b4k

2022-11-01 18:01:02 On the BQ.1.1* and XBB* variant growth, these are the main countries to watch for now https://t.co/UwC8lrswjgIt's early but encouraging to see lack of adverse outcomes so far. More here: https://t.co/UFnDH2Ydwf https://t.co/quIOcIDeaI

2022-11-01 17:50:04 Not enthusiastic about daily or twice daily nasal sprays. Where are the nasal vaccines?https://t.co/eEipWNPNo5

2022-11-01 16:43:13 Some further potential evidence for immune imprinting from a nationwide Qatar study on vaccination, with or without a booster, for protection from Omicron -raddadreinfectionhttps://t.co/qEQm2vTwq4 @HChemaitelly @Laith_AbuRaddad and colleagues https://t.co/zQe0ceataU

2022-11-01 16:26:59 The gut-to-brain axis precise mechanism for how food poisoning and chemotherapies induce nausea and vomiting https://t.co/YyUG2CxY0A @CellCellPress @Tsinghua_Uni https://t.co/POLgCSiO1S

2022-11-01 15:34:42 Just published @SciImmunology The immune response gained from booster shots is largely confined to neutralizing antibodies (nAbs), not T-cellshttps://t.co/G8kB5jB1pT by @LabWalz @YMaringer and colleagues Which links the importance of nAbs to protection vs severe Covid https://t.co/ilIIP82G5D

2022-11-01 15:14:24 Beyond Covid treatments aimed at the virus, there's interest (and FDA approved drugs that can be repurposed) in targeting human protein kinases. And concerns.https://t.co/tZQbUhKGg1 @PostHealthSci https://t.co/Yxhg2TyuNH @scisignal @Tomer_M_Yaron @BrookHeaton5 @heatonlab https://t.co/9IlnmZd32h

2022-11-01 14:53:39 Covid infections disrupt the gut microbiome and increase vulnerability to secondary bloodstream infectionshttps://t.co/OMunSh31Xi@NatureComms @Lucie_Bernard_R @CadwellLab @YaleIBIO @VirusesImmunity https://t.co/7OT2okLeMj

2022-11-01 03:44:45 @mariat444 @Twitter @SubstackInc Will continue to post on Twitter unless or until it becomes unbearable. For the 5 reasons I outlined

2022-11-01 01:09:13 Nevertheless....https://t.co/tKVt1n6zXo

2022-11-01 00:35:20 With @twitter's turbulence, I've decided to post a daily/ frequent brief pandemic update @SubstackInc, beyond the ones I do on biomedicine, #AI, &

2022-10-31 21:26:59 In these uncaring times, do we [physicians] really care? by @BobDohertyDC, former SVP @ACPinternists https://t.co/frOfMQUGtZ @AnnalsofIM https://t.co/UUOnx5HSIL

2022-10-31 18:02:47 @steveagee OK, then here you go, from @dfocosi https://t.co/i6InalnmHS

2022-10-31 17:48:50 Good graphic to simplify what's going onhttps://t.co/M95l9q0bkj

2022-10-31 17:43:34 If you didn't like BQ.1.1's immune escape profile, then you really won't like BQ.1.1.10 and likewise for XBB add- on mutations (or BA.4.6.3, CH.1.1) https://t.co/IHIKgppPc4

2022-10-31 16:49:49 Good question. There's no good excuse why the US isn't aggressively pursuing thishttps://t.co/KkUyGYW9Ei @TIMEHealth by @AliceParkNY w/ @VirusesImmunity @CEPIvaccines @DrRHatchett @cansinobio_inc @BharatBiotech @NIAIDNews

2022-10-31 16:42:13 3. Overcoming bias of self-assembling peptide selectionhttps://t.co/HT0yd38vnU @NatureChemistry @argonne @TroyDLoeffler and colleagues https://t.co/I3IwvFCuUZ

2022-10-31 16:42:11 2. Unsupervised learning of multi-omic microscopic imaginghttps://t.co/a24GkwGUsTby @junbum_kim @afrendeiro @ElementoLab https://t.co/G62clj5FL5

2022-10-31 16:42:09 3 very good #AI papers today1. Graph neural networks #AI for biomedicine and #healthcarehttps://t.co/l5fHAbfNjV by @_michellemli @KexinHuang5 @marinkazitnik @natBME @broadinstitute @harvard_data https://t.co/3RqIbv2bR1

2022-10-31 14:39:01 No, that won't work :-) https://t.co/CPcBb9rViG

2022-10-31 14:08:21 The new variants with marked immune evasive properties are quickly picking up additional mutations. Important thread summary of a preprint just posted. https://t.co/RZofy5MNj6

2022-10-30 19:19:05 @MaskingForAll @Twitter Thank you. I do have a substack and will keep up with posts every couple of weeks or more frequently as warrantedhttps://t.co/YllXWa0b4k

2022-10-30 18:46:21 @morganstephensa What a great chapter and summary you put together https://t.co/fFhqwapn0L

2022-10-30 18:39:07 Graphs are the most recent data posted by @CDCgov https://t.co/HGyjNwCm0v

2022-10-30 18:36:14 The reasons I think it's essential for #ScienceTwitter and #MedTwitter to stay with @Twitter right now—Spread the truth/facts/good info—Counter &

2022-10-30 18:19:39 What if you had something that decreased death by >

2022-10-30 16:55:30 @theheatherhogan @fi_lowenstein @LisaAMcCorkell @priyakamal @chiluvs1 @dunkindona @karlitaliliana @PutrinoLab @WildNycgirl @VirusesImmunity your great chapter on dysautonomia

2022-10-30 16:49:47 What a remarkable #LongCovid info resource by 20 long-haulers &

2022-10-29 19:05:35 The #1 sleuth of life science data manipulation and imaging fraud, @MicrobiomDigest, has analyzed more than 100,000 papers since 2014. She reviews what she's learned and lays out what needs to change https://t.co/AYjYeVcrTP@nytopinion https://t.co/gw75OwQZb7

2022-10-29 17:49:56 @DrSidMukherjee Thinking back. Funny that I reviewed The Gene in Cellhttps://t.co/PYMcpbr1zj https://t.co/fYcV8huFOV

2022-10-29 17:27:33 Q—Before the pandemic, when was the last time an intervention's efficacy and safety was validated in >

2022-10-29 16:27:22 Song of the Cell, @DrSidMukherjee's new book, is an extraordinary work that covers the cell's history and future, along with its mysteries, like he did for genes in The Gene. Reviewed by @DShaywitz @WSJhttps://t.co/ec8WVRk0T6 https://t.co/YUSxRINVEb

2022-10-29 15:25:57 A ranking of the immune evasion for the new variantshttps://t.co/1lrjUMGa9X

2022-10-29 15:21:45 Good summary of the variant swarm/soup status @nature by @ewencallaway with @CorneliusRoemer @yunlong_cao https://t.co/wNwFgdLkvC https://t.co/jvAaShLJqh

2022-10-29 15:15:15 An encouraging sign for one of the (if not the) most immune evasive new variantsXBB is dominant in India and Bangladesh without a rise in cases or deaths to datehttps://t.co/kraBgpFU4V and @OurWorldInData https://t.co/oZdLOXtoSI

2022-10-28 19:37:55 Long-lived plasma cells: real time, cell-by-cell time stamping of their immune response after vaccinationhttps://t.co/bKWGL3a5rp half-life of ~700 days in the mouse model @SciImmunology @MonashUni https://t.co/vRFXcnB8Jy

2022-10-28 18:50:00 Billion-dollar experiments to "escape scientific stagnation"https://t.co/t9uGywZXnS https://t.co/fhmXKtENt6

2022-10-28 17:21:41 @uche_blackstock I'm not going anywhere, Uché. That's how I first met you

2022-10-28 17:18:01 @Nate_DiCamillo @CellCellPress unlocking the article https://t.co/8OakGeNT0I

2022-10-28 17:08:59 The case for some vigorous physical activity: association with reduced mortality, heart disease and cancer in ~72,000 people, mean age 63, followed ~6 yearshttps://t.co/h6XY9Cqms4@ESC_Journals @uk_biobank @Matthew_Ahmadi_ @M_Stamatakis https://t.co/pzYJf68EsU

2022-10-28 16:54:42 "Compelling evidence for the role of carboxylic acid in guiding the mosquito's preference toward specific people"https://t.co/wredsoM8ux @CellCellPress https://t.co/EvMS4VES25

2022-10-28 16:32:26 via @chrischirp In England, the share of cases (and spurt) of BQ.1.1 and BQ.1 is similar to the USHospital admissions are currently on the way down (for now at least) https://t.co/FmfnifCxAT

2022-10-28 15:17:45 @ACPinternists @scrippsresearch Thanks @ACPinternists!

2022-10-28 15:15:25 Besides the hopeful sign from France noted yesterday https://t.co/I4ujEQvJgw Region 2 of the US has the highest BQ.1.1/1, particularly New York, where new hospital admits have not shown a recent rise https://t.co/rcWUlpd8dk

2022-10-28 14:55:38 New US Covid genomics: BQ.1.1 and BQ.1 variants now account for 27% of cases, up from 17% a week ago, on a path to be dominant (>

2022-10-27 22:28:59 On a related front, metabolites from a specific gut microbiome bacterium in people with inflammatory bowel disease can promote tumor developmenthttps://t.co/6NNwlJvWmMhttps://t.co/hPXcuOt3ID https://t.co/72VEts7Soa

2022-10-27 22:15:34 Operation Nasal Vaccine. Please.https://t.co/OujfFxMgU6 @SciImmunology https://t.co/CtoZneSx9O

2022-10-27 21:49:26 Thanks to the swientists!https://t.co/YhPoxt6gaO @ScienceMagazine by @sciencecohen https://t.co/N48xJOHv12

2022-10-27 21:47:32 and this https://t.co/RnhEX54VOD

2022-10-27 19:11:59 @CathyLozupone @KristiKuhn @cu_medicine Agree!

2022-10-27 19:06:02 @BenIsraelow Delighted to do so, especially when it's so impressive and gives us much hope for a far better approach/defense

2022-10-27 18:30:09 Protective efficacy of the spike booster lasted for ~4 months, pan-sarbecovirus, using no adjuvants or replication-deficient or live attenuated virus (like FluMist), elicited broad neutralizing Abs.This is the variant-proof booster we need now to help prevent infections &

2022-10-27 18:16:56 Just published @ScienceMagazine A nasal vaccine booster (after primary vaccination) induces mucosal immunity —IgA, memory B and T cell—against the sarbecovirus family in the experimental modelhttps://t.co/j03xNjIXzhby @VirusesImmunity @tianyangmao and team @YaleIBIO @YaleMed https://t.co/M6LQUZWnlc

2022-10-27 17:44:25 RT @MassMedical: .@EricTopol said it would be a mistake to skip these shots. They still work, they just may not be much of an improvement o…

2022-10-27 17:39:01 Very hopeful signFrance is the 1st country in Europe to see the BQ.1.1 variant dominance (>

2022-10-26 21:05:00 The benefit of vaccination and boosters, along with prior Covid, against Omicron infections, in the California prison systemhttps://t.co/VSwHQIkwrD @NEJM https://t.co/3xg2Yn8DBm

2022-10-26 18:42:07 @Alexander_Tin @CNN @US_FDA @moderna_tx The number of participants in each of the 2 bivalent BA.5 booster independent studies is far greater than the ones Pfizer and Moderna have thus presented (zero) and are quite typical for assessment of neutralizing antibody response throughput the pandemic

2022-10-24 01:51:07 That Singapore's XBB variant wave was not severe, with relaxed mitigation, as @Fiona_M_Russell points out, is v encouraging https://t.co/tJuJ82OOBO —XBB's immune evasion could've ->

2022-10-24 01:21:15 @BagaiDr Many thanks Dr, Bagai!

2022-10-23 20:54:45 A booster is your best shot now. Why?https://t.co/G9Gnosk8E8

2022-10-23 18:04:32 It's not a good sign when 3 shots and a breakthrough (BA.1) infection (lower panel) doesn't elicit neutralizing antibodies to some of the new variants (BQ.1.1, XBB, BA.2.75.2) https://t.co/YS9rbTlSGZ

2022-10-23 16:21:46 RT @paula_span: The new bivalent COVID booster: Older folks, a highly vaccinated group, appear less interested in getting it than earlier s…

2022-10-23 16:17:42 @elderconsult I think the likely explanation is a high rate of prior infection, particularly with the Beta variant which seems to provide more cross-immunity than the others

2022-10-22 22:09:29 Thanks for the critique and feedback, @AstroKatie, @choo_ek and many others. A sense of equivalency was never intended. Preventing deaths, hospitalizations and #LongCovid towers over any liabilities.Here's a fixed version https://t.co/hrlYbI8rEI

2022-10-22 20:10:45 For the first year of vaccines, over 20 million lives saved around the world through December 2021 https://t.co/4GnPgEvg7W

2022-10-22 20:10:44 End of July 202291% reduction of deaths, all ages https://t.co/GIPkSo2daH

2022-10-22 20:10:42 Vaccines and boosters save lives. Across all ages.96% reduction of deaths for 2 boosters vs unvaccinatedEnd of May 2022@OurWorldInData https://t.co/UYkn5iszKT

2022-10-22 19:52:45 RT @cshperspectives: Sci comm irony when the first scientist quoted in a story has deleted their twitter account by the time the article ap…

2022-10-22 19:51:15 @JusDayDa @_TheAncientOne_ @MoritzGerstung Yes, that one is good, too. I had summarized it yesterdayhttps://t.co/fS78A4Vrwr

2022-10-22 19:32:01 @JusDayDa @MoritzGerstung Best I've seen is from @yunlong_cao and colleagueshttps://t.co/qWJ4AGtiur

2022-10-22 19:29:06 Avoiding #LongCovidhttps://t.co/VIVNew8bGWMy interview with @maggiemfox @Medscape, video w/ transcript https://t.co/FOpoBMAEOe

2022-10-22 16:59:36 A review of how #AI has been used during the pandemichttps://t.co/tvjS0ifKFE @PLOSDigiHealth "No clinical trials evaluating any applications impact on patient health" by @RANDCorporation @carlberdahl https://t.co/GeoWpysyyj

2022-10-22 15:31:45 The BQ.1.x wave projection for the US, and calculations for many other countries based on growth advantage vs BA.5, by @MoritzGerstung https://t.co/4TozbJWNLa https://t.co/wtuI1qLi4r

2022-10-22 14:15:56 Their XBB wave was projected to exceed BA.5.Strong NPI mitigation practices and very high vaccine/booster uptake (a top 10 country) likely contributed https://t.co/93Vd3T3Qg2

2022-10-22 14:05:17 This is very good news.The XBB variant wave in Singapore is in descenthttps://t.co/mZS5FePzrNXBB and BQ.1.1 are 2 of the most immune evasive variants and Singapore was the first country to experience a wave induced by one of them, now letting up https://t.co/DbkSC4OPN7

2022-10-22 01:27:48 @BMcranty @AstroKatie @Sarcasmorator I don't consider major reduction of deaths, hospitalizations, and #LongCovid as "meh"

2022-10-21 22:51:43 91% reduction of Covid deaths for age 50+ with 2 boosters, August 2022, vs unvaccinated BA.5 wave https://t.co/HGyjNwCm0v https://t.co/VI7LzxaLtM

2022-10-21 22:11:19 @AstroKatie I'm with you. Trying to provide as much balance as possible

2022-10-21 22:08:33 Yesterday's @CDCMMWR report that shows slippage of protection vs hospitalization after 4 months, age 18+, during BA.5 wavehttps://t.co/DRB7tiyffU https://t.co/1bTzbZvhAv

2022-10-21 22:05:10 @Sara43347888 The answer is NO. The @sfchronicle headline is terrible and worse than that is to have it behind a paywall. Unacceptable.

2022-10-21 22:01:41 For ages 18-49, the 72% reduction of Covid hospitalizations with ≥ boosterhttps://t.co/M2Bu9rj1Ve https://t.co/DX8wcxAzzt

2022-10-21 21:48:59 Since Omicron in late 2021, mRNA booster protection vs infections &

2022-10-21 20:53:57 @JohnRossMD That's one of several refutes See @K_G_Andersen https://t.co/HcVEo29XaAAnd @Friedemann1https://t.co/VJCmgWR1Vj

2022-10-21 20:45:55 RT @JohnRossMD: In case you missed it, UK COVID minimizer Francois Balloux has deleted his account after amplifying a spectacularly wrong p…

2022-10-21 18:27:42 RT @JReinerMD: Pfizer projects that it will make $32 billion from its COVID vaccine in 2022 and $22 billion from Paxlovid. Their plan to ch…

2022-10-21 17:41:28 The BQ variants and the UShttps://t.co/KEeCny0P9A by @ErinMPrater @FortuneMagazine

2022-10-21 16:36:27 RT @K_G_Andersen: BQ.1(.1)* picking up steam, but still too low to be making a major difference in cases/hospitalizations - follow this tre…

2022-10-21 15:59:15 That's right—Covid boosters aren't for everyone.But for WSJ to print this seriously flawed claim about cardiac deaths in men age 18-39 is inappropriate, to say the least https://t.co/KCox0mhlHG https://t.co/NixQ2Uki1R

2022-10-21 15:02:26 New lab assessment of these variantsBQ.1.1 has the most immune evasion and fusogenicityhttps://t.co/5FQn5FxOZ1 https://t.co/PmZPkQHB4n

2022-10-21 14:50:01 What are the #SARSCoV2 variants accounting for US cases?New CDC genomic surveillance updateOn the rise: Predominantly BQ.1 and BQ.1.1 (~17%), also BF.7 (7%), BA.2.75.2On the decline: BA.5, BA.4.6https://t.co/jjl2AnwOWX https://t.co/r7i6cYnjSe

2022-10-21 14:37:20 RT @mhornig: Not convinced efforts to avoid #SARSCoV2 infx are worth it? Think #LongCOVID and potential for #MECFS are fantasy? Please list…

2022-10-21 14:20:48 Myalgic encephalomyelitis was first recorded in 1934 in Los Angeles after an outbreak of atypical polio. It has taken nearly a century and #LongCovid to "get needed attention"https://t.co/ryyI15mfnf @NanetteAsimov #mecfs https://t.co/xOYiOk9R2A

2022-10-21 02:54:11 Keep an eye on New York, leading the country with % cases BQ.1.1, bellwether for the next wave https://t.co/vw77IAyHJj (update, first picked up by @JPWeiland) https://t.co/MPJSVvzqEY

2022-10-21 01:50:07 The inversion (next wave) is likely starting by the rise in hospitalizations. Great time for CDC to stop daily tracking https://t.co/RXymG9t41x

2022-10-20 23:56:25 On the imprinting issue, in the Discussion"antibody responses to some Omicron S[spike]-specific epitopes were hindered by prior antigenic exposure" https://t.co/w9oiWH8s5A

2022-10-20 22:39:04 Is the science information credible? For the competent outsider:https://t.co/cuyEKL762s@danrpimentel @ScienceMagazine https://t.co/z8WsB1TOjF

2022-10-20 20:02:03 The mechanism by which time-restricted eating limits obesity (in mice)https://t.co/gENt2Muxtq@DamienLagarde @kazaklab @ScienceMagazine @ScienceVisualsre:https://t.co/DN3oCsON5y@JoeBass91471540 and colleagues https://t.co/iVqHsgvAy8

2022-10-20 18:57:29 Vaccination alone did not induce neutralizing activity in the nasal mucosa, but that was achieved via breakthrough infections."These observations... .motivate the development and evaluation of a next generation of vaccines administered intranasally." https://t.co/XIaSiKDJ7R

2022-10-20 18:36:12 "We identified an ultrapotent pan-variant neutralizing antibody, that is a strong candidate for clinical development."https://t.co/jlo7fjwCr5@ScienceMagazine @veeslerlab https://t.co/bwBA8q2zfQ

2022-10-20 18:30:15 A feature @ScienceMagazine on what to do about lab virus work https://t.co/aZhzc3k7X8 by @jocelynkaiser https://t.co/Ypyp24G90K

2022-10-20 17:17:31 Also to note that 60%+ max is not the 80%+ protection vs hospitalization that was consistently seen prior to BA.5, (90%+ for Delta and prior strains) and that finding replicates 2 other studies.Underscores the importance and need for a variant-proof, pan-sarbecovirus vaccine

2022-10-20 17:07:07 Why a booster is important to maintain protection from hospitalization: waning immunityNew @CDCMMWR shows the protection vs BA.5 drops down to 37% (2 shots) and 29% (3 shots) after 4 monthshttps://t.co/DRB7tiyffUData are for all ages 18+ https://t.co/Pa0PtdlWIY

2022-10-20 15:30:35 In a prospective cohort of critically ill adults, sequencing the blood (metagenomics) identified the pathogen 99% and predicted sepsis in 74%https://t.co/tQTgyQHSjY@NatureMicrobiol @UCSF @klkalantar and colleagues https://t.co/wx4u4HpqD5

2022-10-20 13:33:04 "Middle-aged people accounted for the biggest losses in life expectancy"https://t.co/czRQeP2WkHMore at "In America and eastern Europe, covid-19 got worse in 2021" https://t.co/SxZup76Cic

2022-10-20 12:47:01 RT @bmj_latest: “This virus is so amenable to taking it down . . . But we’re just not acting like we can do this. And we can.” @EricTopol…

2022-10-20 01:56:23 RT @EricTopol: There's a lot of total BS out there about myocarditis in kids and adolescents. To state facts:1. CDC does NOT decide about…

2022-10-19 22:20:40 For children 5-11 years in males, 2nd dosethe rate is 2.5 per million https://t.co/kXEH3wMsZl

2022-10-19 22:14:25 There's a lot of total BS out there about myocarditis in kids and adolescents. To state facts:1. CDC does NOT decide about Covid vaccines in schools 2. There are no kids dying of myocarditis from the vaccines3. It is very rare, mild 4. The anti-vaxx world has gone beserk

2022-10-19 21:56:45 The BA.4.6 variant accounts for ~12% of US Covid cases (pattern of growth below, left). Its level of immune escape was characterized @NEJM today: 2-3 fold less neutralizing antibodies than BA.5 (below, right)https://t.co/WdRlUvagsW @BarouchLab https://t.co/HCJYiczVfX

2022-10-19 21:38:19 A timely, outstanding @NEJM review on myocarditis today https://t.co/WAT7pvAMZX by @Cristinabasso64 https://t.co/kx9NytqNro

2022-10-19 21:06:24 Randomized, placebo-controlled trial of the 2-dose @moderna_tx vaccine in children 6 months to 5 years, during Omicron. Safe in ~4,800 kids

2022-10-19 21:00:25 New @NEJM"Our study indicates that [Pfizer] vaccine-induced myocarditis in adolescents appears to be a rare adverse event [<

2022-10-19 19:10:16 "Alexa, what's a mechanical neural network?"https://t.co/3d8yQNsBO1 @SciRobotics #AI https://t.co/X5TbigpMCa

2022-10-19 18:00:25 4. No increased risk of miscarriage or other pregnancy complications from vaccination or booster https://t.co/mVFxD3aE8e

2022-10-19 18:00:23 3. Newborn/infant (0-5 months) avoidance of hospitalization by mother's vaccination https://t.co/T2Wut9L6kK

2022-10-19 18:00:21 2. Vaccination protected vs hospitalization vs Delta and Omicron infections with booster (same with ED or urgent care visits)But 57% of expectant mothers have not been vaccinated or had a booster https://t.co/e9BEJwfVse

2022-10-18 23:34:04 RT @morgfair: I got my booster AND flu shot 3 weeks ago. Please consider making time to get these vaccines in order to protect yourself and…

2022-10-18 23:32:35 And it looks like the 25,000 threshold was not crossed after all, erroneous data @medriva https://t.co/tYv0wdLUup

2022-10-18 23:27:30 @JPWeiland Very strange, since they were in synch, ??

2022-10-18 23:19:33 Sadly, an inversion is in the works in the weeks ahead.And that will be amplified by lack of US booster protection, especially in age 50+, but there was 72% reduction of hospitalizations during BA.5 for age 18-49 https://t.co/M2Bu9rj1Ve https://t.co/2mB1G9juGg

2022-10-18 23:09:33 Today is the first time US Covid hospitalizations went below 25,000 in 5 months https://t.co/Y2TdaIXScs

2022-10-18 23:02:07 Denmark's BA.5 wave. Prior Omicron infection plus booster had high protection against reinfection (93%) and hospitalization (96%). The risk of BA.5 hospitalizations was higher than the prior BA.2 wavehttps://t.co/0G1oRpViRd @TheLancetInfDis @C_HHansen @SSI_dk https://t.co/1hI1eg0PlH

2022-10-18 21:04:49 Reinfections, from @sporeMOH https://t.co/YiAqPtn4LV https://t.co/yvL2JVmiTq

2022-10-18 19:58:11 We've been thinking that the Omicron variant evolved from an immunocompromised individual with accelerated in vivo mutations. A new report @PNASNews raises the potential that it emanated from mice ->

2022-10-18 19:41:38 RT @florian_krammer: 1) Boston University researches have made a SARS-CoV-2 virus that has the spike of Omicron BA.1 and the remaining geno…

2022-10-18 18:46:11 The human asks: "Is there a bacteria on the slide?"The #AI responds: "Yes, indeed, and I've identified it for you"https://t.co/6d14dbMWAn @naturemethods developed by @KevinJohnCutler, a @UW physics grad student, with explanatory thread below https://t.co/axnXgss6qr

2022-10-18 18:01:02 Each day in the United States our immunity wall (vs severe Covid) develops more cracks in itWhy?Far more people have their vaccine or infection-induced immunity waned than are getting a booster

2022-10-18 17:24:41 ImmunosenescenceAdvanced age and reduced Covid mRNA vaccine induction of neutralizing antibodies and T-cell responseAnother reason why boosters, by preempting waning immunity, is so important in older age groupshttps://t.co/SF7YhiRIRs @NatureAging https://t.co/76cQS4hq5K https://t.co/U3gZaJgbax

2022-10-18 16:00:50 The XBB variant wave in Singapore will soon be their 2nd worst for the pandemic. The reinfection rate prior to the wave was 5% and now up to 17%, which tells us about the immune escape properties of this variant (akin to BQ.1.1, very high level of immune evasion) https://t.co/IMoMuymp75

2022-10-18 15:26:11 For essential workers, a recent (<

2022-10-18 15:15:22 The US purchased 171 million bivalent BA.5 booster shots

2022-10-18 14:32:36 Inflammation and dysfunction of the lining of blood vessels—the endothelium—is the basis for many of the cardiovascular complications of Covid. A new, solid review here https://t.co/1GiS8XXzT7 https://t.co/CSBS7xjXCR

2022-10-18 03:49:18 RT @dnewheiser: In case it wasn't clear, the widespread prevalence of long COVID is a VERY BAD THING.@EricTopol explains that COVID is as…

2022-10-17 23:23:08 "The results reveal inequalities in molecular risk factors for chronic diseases often decades before diagnoses"Linking socioeconomic status (SES) and mRNA signatures of disease in >

2022-10-17 21:45:07 The choice of blood thinner for patients w/ atrial fibrillation &

2022-10-17 21:33:41 Why reducing the cost of insulin is critical"A total of 16.5% (95% CI, 13.8% to 19.6%) of insulin users rationed insulin ["to save money"] in the past year, or 1.3 million adults with diabetes nationwide."https://t.co/l6Vnd1WYD7@AnnalsofIM https://t.co/d7y1Borr49

2022-10-17 21:20:49 "Countries with a higher share of vaccinated individuals suffered the least life expectancy deficit."and to note bounce back of USA for age 80+ in 2021https://t.co/EM2Fq0hciJSummary of the paper@jschoeley @jm_aburto @ridhikash07 @OxfordDemSci https://t.co/gHSvgiTj90

2022-10-17 18:21:33 How to protect vs the XBB variant wave in Singapore?With the new and significant wave, cases are up, along with hospitalizations. The 79% population booster rate (double the US) is helping to avoid severe outcomes https://t.co/mZS5FePzrN @sporeMOH https://t.co/JVmgqD15OW

2022-10-17 18:06:14 Biomarker hunt for correlation with #LongCovid risk 7 months out from 108 people with mild to moderate Covid comes up with candidates such as Rig-1 and multiple cytokineshttps://t.co/lESwHXAmWv@eLife https://t.co/5q4qRgJxxU

2022-10-17 16:09:10 In contrast to most other countries, the life expectancy decline in the US occurred across all ages 20+ "In the United States, the pandemic has accentuated the pre-existing mid-life mortality crisis. This is clear from the strong contribution of increasing mortality <

2022-10-17 15:55:44 Making human salivary gland organoids to determine #SARSCoV2 infectivity https://t.co/GkOjqWt2c9 @NatureCellBio "SARS-CoV-2 derived from saliva in asymptomatic individuals may participate in the spread of the virus" https://t.co/cWRA6BgBi1

2022-10-17 15:11:30 Life expectancy changes during the Covid pandemic among 29 countries: the US among the most pronounced reduction. Several countries had bounce back improvement in 2021 (black arrows below). Vaccination uptake was correlated w/ less deficithttps://t.co/DIxN3ZrvsK @NatureHumBehav https://t.co/GE2VJMjP84

2022-10-17 14:25:01 Good review of the treatments that have been validated for Covid https://t.co/aavLANCV4A by @nymurakami @DavidLeaf9 and colleagues @BWHKidney @NatRevNeph https://t.co/WRqSbh81WP

2022-10-16 22:47:21 RT @JPWeiland: Something interesting is happening in New York. Cases have been flat over the past month, however hospitalizations are jump…

2022-10-16 18:25:06 The @sporeMOHreport on the XBB variant wave https://t.co/LwzJzRh2Hk…—Expects peak of 15,000 cases/d (>

2022-10-16 15:40:11 RT @florian_krammer: Ours is moving. Phase II in Mexico, Phase I in the US. But funding in the US for these vaccines is hard to find.

2022-10-08 15:32:28 Our digital times :-)by @speedbumpcomic https://t.co/LzEjDTehAV

2022-10-08 14:50:36 The start of Singapore's XBB variant waveNotable how this variant left BA.2.3.20 in the dust, a variant with substantial growth advantage over BA.5

2022-10-08 01:55:55 Keep this summary data--preventing deaths--in mindhttps://t.co/Vc87IkH9WS

2022-10-08 01:52:24 2 key data points from the segment https://t.co/yjL0j9YNQC

2022-10-08 01:34:54 A data-driven segment on vaccines and boosters worth watching.Thanks @chrislhayes for staying on this as we face a new wave in the weeks ahead with an exceptionally low (34%) booster rate (half that of all high income countries) https://t.co/N2K3QCptrz

2022-10-07 22:15:48 @DanRather To support you point, DanLives saved in 2021 by Covid vaccines and boostershttps://t.co/ICyk0xZBiG

2022-10-07 18:50:43 Why do some people develop blood pressure dysregulation after severe Covid?https://t.co/yYGSMBTWQc@ScienceAdvances by @UChicagoPME @UChicago @srouhani1 and collaborators https://t.co/G5X7hIbHHC

2022-10-07 18:07:31 For more on today's UK report, an informative thread https://t.co/Dnz16oZ8ko

2022-10-07 17:54:04 New weekly US genomic surveillance https://t.co/jjl2AnwOWXBA.5 continues to fade as BA.2.75x creeps up, BF.7 (BA.5.2.1.X) &

2022-10-07 17:31:38 In a large US cohort of ~200,000 people who had Covid, vaccination reduced the risk of #LongCovid by 30-40% and this protection persisted through breakthrough infectionshttps://t.co/UqFViYOWdm

2022-10-07 17:02:35 A new profile on @Tuliodna &

2022-10-07 15:03:14 RT @EricTopol: @ArianaSeigel Since Omicron emerged, the vaccine/booster protection vs infection and spread has diminished and is less durab…

2022-10-07 14:15:21 RT @hholdenthorp: The medical establishment, especially @AAMCtoday and @AmerMedicalAssn, really needs to own the damage they are doing by n…

2022-10-07 14:10:56 The US booster rate (34%) vs peer, high income countries https://t.co/DVvWNke276

2022-10-07 13:51:21 @cindymclennan @NatureMedicine No, it's the BA.5 bivalent, but we don't have such data on that yet. This Beta variant bivalent was never made at scale

2022-10-07 13:45:42 @JELesq Yes. Read Ryan Hisner's threadhttps://t.co/hSwCNBpMHc

2022-10-07 13:39:46 New and encouraging @NatureMedicine on bivalent Beta booster"These results indicate that bivalent booster vaccines can induce potent, durable and broad antibody responses against multiple variants, providing a new tool in response to emerging variants"https://t.co/H5Q98bXoHa https://t.co/reK5Jx99sx

2022-10-07 12:51:24 The US booster rate is less than half of all its peer countries, leaving Americans vulnerable now and as the next wave hits in the weeks ahead. By ⁦@ddiamond⁩ ⁦@VPMaryBeth⁩ ⁦@majohnso⁩ https://t.co/f4OYPlfvFd

2022-10-07 03:07:23 New on MolnupiravirA randomized trial of ~26,000 patients with Covid, mean age 57 with 2 days of symptoms, showed no difference in hospitalizations or deaths, the primary endpoint, compared with usual carehttps://t.co/6ai5AawdLn https://t.co/HIF845BRLx

2022-10-06 23:01:43 In my clinic today, after routine 6-lead ECG and during smartphone echo, a faster heart rate was noted. Repeat 6-lead ECG showed atrial flutter. All part of the extended physical exam with sensors

2022-10-06 21:06:12 Good summary today on this innovation and why time to diagnosis is so critical https://t.co/F5SxIIcsnQ @Medscape

2022-10-06 20:21:23 Masks help. So do vaccines and boosters.Japan has the lowest Covid death rate of any large country in the world, per capita https://t.co/adUZVdUcu8

2022-10-06 17:38:48 @TigerlillySusan BQ.1.1 is there but not at levels that would be driving a case wave (yet)

2022-10-06 17:32:23 Unlike Singapore, where the XBB variant wave has begun https://t.co/cT9YQbHiBn

2022-10-06 17:32:22 Here we go, before the new variants kick in https://t.co/FwMmKSqE73

2022-10-06 17:09:02 The #AI can "see" kidney disease from your retina and anemia from your electrocardiogramhttps://t.co/l8GkL5vyaC

2022-10-06 15:13:46 "During the pandemic, the practice [in Japan] became pervasive, though the gov't has never enforced a mask mandate... A recent survey showed that half of Japanese would like to keep wearing masks as much as possible, regardless of medical advice or rules."https://t.co/Avfztzfd0R

2022-10-06 14:44:48 https://t.co/OsGmJVDZzW

2022-10-06 14:32:12 It's "Data Liberation Day" in the United StatesPatients can now access all *their* health records A real liberation would mean having, controlling, owning all *our* medical datahttps://t.co/zATgTyrhhC @statnews @caseymross

2022-10-06 14:25:27 @TWenseleers Start of the first XBB wave? https://t.co/J4VpmygBdB

2022-10-06 01:13:22 RT @TWenseleers: @EricTopol @Tuliodna This is the growth rate advantages I am getting of these different emerging lineages based on a fit t…

2022-10-06 01:03:25 The relationship between climate and CovidA comprehensive and very thoughtful assessmenthttps://t.co/Rb90ME8Rky @TheLancetPlanet @ccadapt @B_vanBavel @carolzavaleta and colleagues https://t.co/jwg3ZOrNBB

2022-10-05 23:37:54 @Tuliodna Hope you are right, TulioBut some of these look pretty menacing (especially BQ.1.1 and XBB right now)

2022-10-05 23:18:33 There's also this new study on T-cell immunity induced by prior infections or vaccination or both (hybrid)https://t.co/VHneulgImm@NatureComms https://t.co/KoNPpMPjH2

2022-10-05 23:18:32 There has not been adequate regard for the level of immunity acquired from Covid infection, albeit with its attendant risk and unpredictable #LongCovid sequelae.I reviewed many of the earlier studies in this threadhttps://t.co/dWMGRpKKVa

2022-10-05 23:18:31 A systematic review for protection vs Omicron hospitalization or severe disease out to 6 monthsHybrid immunity + 3 shots 95%Hybrid immunity + 2 shots 96%Prior Covid alone 80%Vaccination (2 shots) alone 65%https://t.co/z0JxOhaaZM @nikbobrovitz @lsubissi https://t.co/JS2dSTpEj3

2022-10-05 21:20:50 Prior Omicron infections protected against BA.5 (~80% effectiveness) whereas prior Covid, non-Omicron protection was markedly lower (~30%). Likely related both to immunity waning and cross-immunity within Omicron lineageshttps://t.co/kEtABqGH97 @NEJM https://t.co/V9wjEcGczS

2022-10-05 18:46:25 @AmyGlaw_1 @RajlabN @CorneliusRoemer Thank you. Yes, definitely

2022-10-05 18:33:27 RT @rkhamsi: Holy smokes! This is maybe the most important paper I’ve read in 2022…We know that this #COVID virus is good at hiding from…

2022-10-05 18:26:58 Knock 'em all out.Discovery by @EmoryVaccineCtr of a broadly neutralizing antibody (bnAb) vs all #SARSCoV2 variants through BA.5. Could be used alone or in combo w/ other bnAbs to make a variant-proof vaccinehttps://t.co/r3YDB1FOB0 @ScienceAdvances @SanjeevKumar_01 https://t.co/nUWf21gUuX

2022-10-05 16:42:27 "Alpha Tensor typically discovers thousands of algorithms for each size of matrix""Algorithms that multiply large matrices 10-20% faster than those commonly used on that piece of hardware"from the Cliff Notes versionhttps://t.co/8VPDQ2ySAT https://t.co/ZhWI3enwhY

2022-10-01 01:18:36 RT @marypcbuk: I valye twitter for precisely this flattening

2022-10-01 00:36:14 @dan_psyd Agree https://t.co/XrEHsI1uC5

2022-09-30 23:33:25 On the two-edged sword of @Twitter, by @richardhorton1 @TheLancet https://t.co/JXjjw150JZThanks for the mention with @chrischirp https://t.co/7GR1Kf1Xoh

2022-09-30 23:14:54 Already high before the pandemic, the alarming current rate (63%) and increase in physician burnout "We cared about quality of patients' experience, building relationships with them"https://t.co/MJJfpv5kHk @oliverwhang21 w/ @JBryanSexton1 @JBryanSexton1 @MayoProceedings https://t.co/YhcozuPjQh

2022-09-30 19:05:57 RT @CatchTheBaby: @RajlabN Thanks. This is very helpful.BQ.1.1 is concerning since it is resistant to both Evusheld and Bebtelovimab. http…

2022-09-30 18:59:36 Broadly neutralizing antibodies (bnAbs) are the template for variant-proof, pansarbecovirus vaccines. A new review shows the extensive discovery work has been to find bnAbs, and these are just vs the spike protein!https://t.co/dN8XsURly3@NatRevImmunol https://t.co/3DvfXiwOHN

2022-09-30 17:54:15 Current data (28 September), for those past 6 monthsAge 65+, <

2022-09-30 17:08:44 Each day in the US we have far more people whose immunity has waned, >

2022-09-30 15:58:59 RT @Tuliodna: Early reflections of the historical event @Illumina genomics forum. In this short thread, I highlight that it is not the tech…

2022-09-30 15:16:20 New US genomic surveillanceAs the BA.5 variant proportion of cases descends, the rise of BA.4.6 (13%), BF.7 (aka BA.5.2.1.7

2022-09-30 14:50:51 We've seen this movie before@OurWorldInData https://t.co/rIIR21VdsA

2022-09-30 14:39:24 No, people don't die of "old age."https://t.co/KmASnvxZNs by @MarkLandler https://t.co/viETh0rE1Hby @miho_inada https://t.co/Rm7ll7jXW6

2022-09-30 01:19:05 For #AI to be an integral part of medical practice, compelling data from randomized and prospective trials are needed. A new systematic review of all 41 RCTs shows the weak status of what has been done to datehttps://t.co/Gj8ToPdGJZ @PlanaDeborah @dlshung @BenjaminKannMD https://t.co/WdJ7iZAy4z

2022-09-30 00:42:06 RT @TIME: "Hannah Davis (@ahandvanish)’s advocacy has been a light in the darkness for many people whose Long COVID struggles have been dou…

2022-09-29 22:00:38 "We show how this [science-guided] battle got lost on Facebook very early during the COVID-19 pandemic and why the mainstream majority, including many parenting communities, had already moved closer to more extreme communities by the time vaccines arrived"https://t.co/IMUyqA80Xo https://t.co/qFrA74XBNs

2022-09-29 21:31:02 And here's a short video what we're doing for a universal, variant-proof Covid vaccine, via joint efforts of immunology and structural biology, with @DennisRBurton and Ian Wilson, @WardLab1https://t.co/yjYPkSBERa

2022-09-29 19:20:04 How to accurately identify an uncommon and lethal disease (IPF) 1 to 4 years sooner than in general medical practice?Train #AI with data from 3 million people, >

2022-09-29 18:56:34 New @USGAO @theNAMedicine report on #AI in healthcare https://t.co/ZHui8ACW92 addressing the challenges, glad to have participated @theNASEM https://t.co/T0mqQ6i0LW https://t.co/MhIq0hhNnm

2022-09-29 18:40:43 My @scrippsresearch colleagues just published @nchembio a new oral drug vs Covid that blocks ACE2 binding to the spike protein, inhibiting viral entry and infections in the experimental modelhttps://t.co/lronrARbxU https://t.co/a18sJ64O1a

2022-09-29 17:49:30 @ImmunomePro @waynekoff1 @TedSchenkelberg So glad to be a part of this new and exciting initiative with planning over the past few days, bringing together leading immunologists and computer/data scientists from all over the world

2022-09-29 14:23:11 False positives and unnecessary biopsies frequently arise from mammography screening for breast cancer. A new study using #AI of MRI scans shows the potential for much improvement https://t.co/uCZy32IBlp @ScienceTM @JanWitowski @kjgeras@nyuniversity @nyugrossman and colleagues https://t.co/CsTpJA7EI7

2022-09-29 01:17:37 He basically summarized we've made solid progress with genomics research, such as with the @AllofUsResearch program, but slow to move to the clinical realmAgree. We'll get there eventually....... https://t.co/NmbW8oHwNc

2022-09-29 00:42:20 Good to hear @BarackObama’s candid appraisal of where we stand with precision medicine #IGF https://t.co/cfyBBeFy7i

2022-09-28 19:35:51 RT @Alex_Aravanis: Looking forward to hearing from @francesarnold, @EricTopol, @amyleecp3, @j_echevarria, @clopezcorrea, and @WohlgemuthJay…

2022-09-28 16:20:29 The Lasker-DeBakey Medical Research Award today for discovery of circulating cell-free fetal DNA, the foundation for prenatal screening. Congratulations to Dennis Lohttps://t.co/N8tKiMKoSQ @NEJM @LaskerFDN https://t.co/g2RXi6W3iz

2022-09-28 15:48:15 What may be the sequelae of the new variants https://t.co/f37WFDZaUn by @GretchenVogel1 @ScienceMagazine (hint: the pandemic isn't over)And my simplified version of @dfocosi'soutstanding convergence map highlighting the 2 variants discussed in this piece https://t.co/GwfrweY5iO

2022-09-28 14:29:15 A small pilot study of plasma proteomics in health care workers with mild Covid or controls suggests potential for predicting #LongCovid https://t.co/Nygcmq4VN8 @eBioMedicine @uclnews @gabycaptur @DrWendy_Heywood https://t.co/y7anc6T31W

2022-09-28 02:37:15 @Tuliodna @christian_happi @fdesouza @illumina Welcome, Tulio and team, to Capetown of the US, without Table Mountain

2022-09-28 00:12:24 Has the β-amyloid hypothesis for Alzheimer's (AD) finally been proven? Results of a Phase 3, placebo-controlled trial of a monoclonal Ab in 1,800 participants with early stage AD raises the possibility (need to see all the data)https://t.co/npXgPzNAht https://t.co/OYlvevWCNv

2022-09-27 22:53:24 The BA.4.6 variant now accounts for >

2022-09-27 22:16:49 How long is Covid infectious and what's the best way to track it that correlates with culture positivity?"Most adults have replication-competent #SARSCoV2 for 10-14 after symptom onset, and N antigen testing is a strong predictor of viral infectiousness"https://t.co/we0hTuzKjk https://t.co/uf1AVGd5ZT

2022-09-27 18:26:48 @dfocosi @TRyanGregory @florian_krammer @Tuliodna @CorneliusRoemer @PeacockFlu @DrEricDing @kakape @SolidEvidence @ewencallaway @RobertoBurioni @mlipsitch @JeremyKonyndyk Info overload!My dumbed-down version https://t.co/Vfq1xPrKHw

2022-09-27 18:03:50 Current CDC recommendations>

2022-09-27 17:11:56 A very interesting report that adds to the possible underpinnings of #LongCovid. Reactivation of viruses such as EBV has been raised, along w/ persistent remnants/reservoir of #SARSCoV2, and autoimmunity. But imprinting from a common cold coronavirus is unlike these mechanisms

2022-09-27 15:46:49 The Cliff Notes version of this important study@NatureMedicine https://t.co/vwzkq448LU https://t.co/tlYdhUsepI

2022-09-27 14:53:21 Good summary @PopSci integrates findings from a 3rd report https://t.co/R9AwAdv7cZ by @LPBaisas

2022-09-27 14:42:37 The persistent excess of arterial and venous blood clots after Covid at 1 year compared with controlshttps://t.co/phpGVQgCOh @CircAHA by @jonathanasterne and colleagues https://t.co/Q0ONqbnHr3

2022-09-27 13:56:37 @DFisman @kasza_leslie @VirusesImmunity Thanks David! Prime + nasal boostThe link for those interestedhttps://t.co/OujfFxvdS6 @SciImmunology

2022-09-27 13:33:48 New @CellCellPress Why getting a booster too soon after Covid is not a good idea: suboptimal B-cell responsehttps://t.co/ZMFiSFxa0R@NIAIDNews https://t.co/GGMfM2OATG

2022-09-27 01:34:49 These results are derived from ~450,000 people prospectively followed for 12.5 yearsChallenging medical dogma, arrhythmias were reduced by coffee (caffeinated, not decaffeinated), as was heart failure and strokeUsual caveats of self-reporting https://t.co/AUpZKemkW0

2022-09-27 00:23:53 Coffee lovers will love this new report

2022-09-25 15:57:46 @luckytran Over 200,000 Americans died from Covid in 2022 and still now >

2022-09-25 15:34:16 A good graphic on imprinting. We don't yet know how well the bivalent BA.5 will do, but boosters are our best shot for maintaining high level protection vs severe Covidhttps://t.co/aqOp2TpAUDSummary of what's known about boosters

2022-09-25 15:19:54 Sneak preview of what's to come from @JosetteSchoenma BA.2.75.2 and BQ.1.1 in 3 countrieshttps://t.co/qqPnt9vYqO

2022-09-24 21:55:55 @AlbertBourla @loscharlos "Back in mid-August"A reinfection in such a short time bespeaks the big unmet need to block infections and spread, which we're not going to get better at with shots at this point

2022-09-24 17:53:46 Nothing to worry about out there

2022-09-24 16:14:28 The 4-D ultrasound image of the fetus (age 32-36 weeks) after the mother eats kale :-)https://t.co/FIkqxdi30C https://t.co/aBe91sTWUS

2022-09-24 16:01:35 Our metabolites indicate risk of more than 20 common diseases beyond traditional clinical risk factorsNew @NatureMedicine report from ~120,000 participants, >

2022-09-24 15:51:26 Retina images are emerging as a window to blood pressure and glucose control, kidney and hepatobiliary diseases, risk of heart disease, and Alzheimer's. Could they be a biomarker for #LongCovid?https://t.co/AFUypPKoZt https://t.co/DXhxQREHbD

2022-09-23 22:32:29 RT @captainslim: I’ve been enrolled in this study almost since it started. I’m fascinated by the idea of using passively collected data fro…

2022-09-23 20:31:25 Pandemic virus sequencing has provided the notable edge of seeing variants before they go exponential, characterizing them, determining in advance whether and which treatments (mAbs), vaccines will be effective More here: https://t.co/xr8J0OtwED by @PhilFebboMD_CMO

2022-09-23 20:22:53 And my prior post on 2 with immunoprofiling (BA.2.75.2 and BQ.1.1)https://t.co/p6F7JAUxFc

2022-09-23 20:21:00 New info on the major variants on the radar screen, by @yunlong_cao https://t.co/Qg4Nxc0W82

2022-09-23 19:59:30 These 2 large studies are consistent and concerning.Reminder: it took ~15 years after the 1918-9 pandemic to pick up the increased risk of Parkinson's disease among survivors.

2022-09-23 19:40:25 The immune system response &

2022-09-23 19:01:54 Work @ScienceMagazine w/ @ScienceVisuals Report by Yang Cao @zhenqi_zhou @MarcusSeldin @DOM_UCLA @KeckMedUSC @dgsomucla Perspective by @josephahill https://t.co/ts08EMj8BL

2022-09-23 18:51:57 We know about the heart-brain and brain-gut interactive axis. Now there's the liver-heart:A clotting factor (FXI) made in the liver protects the heart (unexpectedly) from failurehttps://t.co/vG2cFlo0Jghttps://t.co/4BqeHEiMyu https://t.co/ZizV6OvrbO

2022-09-23 15:57:34 Note. Good time to be sure you get a booster if you're ≥4 months out https://t.co/bi4HV1cdHj @NicolaKSDavis @guardianscience https://t.co/Iy3EfcY5nXhttps://t.co/KRqlB6UNMx @ONS https://t.co/ZC3UCHbDCo

2022-09-23 15:36:24 Using epigenomics (methylation markers) a person's biologic age can be determined fairly accuratelyNow digitizing #brain age is getting attention via imaging #AIOur new @Lancet Digital Medicine essay@DavidJonesBrain @NaipMayo https://t.co/bA6ypagsJC https://t.co/VRAx1Bk8r2

2022-09-23 15:12:15 Two new independent reports, one Norway nationwide, and the other US-based, indicate increased risk of Type 1 (autoimmune) diabetes from Covid in children and teenshttps://t.co/8zTYGLmblk@EASDnews https://t.co/q4t1DfcYk9 @JAMANetworkOpen https://t.co/fn1Wqnf2Th

2022-09-23 14:39:15 For opera, "It ain't over till the fat lady sings"For the pandemic, It ain't over (contained, under control, ahead of it) till we get better vaccines that block infections and spread (e.g. nasal) and are variant-proof, pan-sarbecovirus

2022-09-23 14:11:17 And @EllingUlrich has an insightful thread about both the convergent and non-convergent mutations for the new variants https://t.co/M6yWQqEren https://t.co/WgB5SZXZEv

2022-09-23 14:11:16 Here @SolidEvidence has mapped out their evolutionary path with a convergence of several mutations https://t.co/XEfxyTn0n0

2022-09-23 14:11:14 New US #SARSCoV2 genomic surveillance dataThe proportion of BA.5 cases is declining, as new variants are out-competing, some of which have already been shown to have more immune escape such as BA.2.75.2 and BQ.1.1https://t.co/jjl2AnOYb5 https://t.co/FUSgl3CAR0

2022-09-23 13:54:27 RT @NatureMedicine: In our latest Review: Multimodal #AI models could unlock many exciting applications in health and medicine

2022-09-23 01:41:31 The global Covid death toll would be more than double by now without vaccines (about 50 million people died in the 1918 influenza pandemic)https://t.co/RGe96GeJ5s

2022-09-23 01:31:34 Although we have no validated treatments yet for #LongCovid, a new @bmj_latest paper provides practical support and guidance for both patients and clinicians https://t.co/eBKGloKDEI by @trishgreenhalgh @sivanmanoj @bcdelaney1 @REvans_Breathe @ruairidhm https://t.co/1DGWMqjOxI

2022-09-22 23:54:39 Why wrist sensor surveillance should be part of pandemic monitoring https://t.co/2cTRFyybzg @LancetDigitalH by @jmradin @GiorgioQuer @JayPandit @ScrippsRTI @careevolution @SteveSteinhubl @BacaMotes @ERamosPhD @GadaletaMatteo @scrippsresearch https://t.co/0GyqYpqBif

2022-09-22 21:09:42 Think outside the spike (again)#SARSCoV2's ORF7a protein inhibits antigen presentation CD8+ T cells, may contribute to immune evasion https://t.co/toygmNWQxE@PNASNews @PaulBieniasz @RockefellerUniv https://t.co/ACjP7UYZHK

2022-09-22 20:33:26 @hholdenthorp @alanalda I love @alanalda Here's is our back and forth after I got the @ScienceMagazine review back for Covid and the heart https://t.co/Ql4PIA6rBE

2022-09-22 18:58:28 Why is obesity an important risk factor for severe Covid?@ScienceTM, a potential contributing factor #SARSCoV2 infects fat cells -->

2022-09-22 18:19:06 Discovery of a Sarbecovirus (Khosta-2) in Russian bats resistant to neutralization in serum from people who had Covid vaccineshttps://t.co/XTdua8Hwa0 @PLOSPathogens "Our findings ...underscore the urgent ned to develop broader-protecting universal sarbecovirus vaccines" https://t.co/oRRfPOrn4A

2022-09-22 17:15:38 A big brain dayhttps://t.co/M62pTCsKFf @ScienceMagazine @ScienceInsider Congrats @JoeEcker @salkinstitute to lead $126M effort to map aging human brainAnd a report @TheEconomist https://t.co/sS02x3pV2f @natashaloder https://t.co/LMSk5hSdOM

2022-09-22 16:59:00 RT @firefoxx66: What should we expect from #SARSCoV2 this autumn?I think it would be smart to prepare for both an increase in #COVID19 du…

2022-09-22 16:08:02 Some context:—77% White males (Veteran population), so generalizability—<

2022-09-22 15:05:02 Here's the breakdown by risk of outcome and excess burden per 1,000 people https://t.co/rwCEybLbk5

2022-09-22 15:03:08 @NatureMedicine Comprehensive analysis of #LongCovid neurologic outcomes at 1 year from >

2022-09-22 14:11:19 Congratulations @demishassabis @DeepMind for being awarded the Breakthrough Prize today #AlphaFold #AIhttps://t.co/kZSwCaOWwc"Few discoveries so dramatically alter a field, so rapidly” --@MoAlQuraishi

2022-09-22 14:00:12 The true pandemic death toll is currently ~22 million, not the official 6.5 million https://t.co/57lVnlqOPIMarked variance in official vs excess mortality between countries https://t.co/iCyz9XSYlU

2022-09-22 13:38:29 I don't usually agree with Paul Offit on his booster take but he makes a few good points herehttps://t.co/MzWuOJ4yu7 https://t.co/WeekdGZdQg

2022-09-22 13:35:30 New neutralizing antibody data for BA.1 and BA.5 boosters, monovalent or bivalent, in micehttps://t.co/xlSWTEh6st @BioNTech_Group BA.5 better than BA.1 (for BA.5 counter)

2022-09-22 13:14:40 Our Covid times :-)by @Walt_Handelsman https://t.co/U5QjdLm4nj

2022-09-22 02:45:04 Here is a graph showing the current growth advantage of BQ.1.1 and BA.2.75.2 relative to BA.5.2* in the UKhttps://t.co/wbicHdEOqX https://t.co/5fs2qBgWhD

2022-09-21 23:50:04 RT @thrasherxy: In its most lethal year, 1996, AIDS took about 1,100 lives in the United States each week. Last week, COVID took at least…

2022-09-21 22:45:55 Recovery >

2022-09-19 01:43:20 @meganranney Thanks Megan!

2022-09-19 01:02:26 Or that only 1 of 3 Americans have had any booster shot. A proclamation "it's over" is not going to help that https://t.co/oSnWZYX75g

2022-09-19 01:02:25 And what about the 400-500 Americans dying each day since April https://t.co/LduqLo6Iu2

2022-09-19 00:38:26 Wish this was true. What's over is @POTUS's and our government's will to get ahead of it, with magical thinking on the new bivalent boosters. Ignores #LongCovid, inevitability of new variants, and our current incapability for blocking infections and transmission https://t.co/sZyChorhC9

2022-09-19 00:28:03 @TheLizArmy Much appreciated and fully identify with you

2022-09-19 00:00:32 @terrawellington Great question. We need to push our government hard to invest in more durable and effective, variant-proof nasal sprays and shots. Instead of wasting $ billions on >

2022-09-18 18:14:51 For now: get a booster. It's the best shot you have to stay maximally protected (unless you had BA.5). It's worth the early side-effectsFor the future: we need a better strategy that prevents infections, transmission (ergo #LongCovid) and is far more durable, variant-proof

2022-09-18 18:14:50 12. There are no data to show durability of boosters vs severe Covid beyond 4-6 months. Or to even show that the new (? more potent) bivalent Omicron BA.5 will perform better than original or BA.1 bivalent boosters. A ≥ 2-time booster strategy per year is untenable, long term.

2022-09-18 18:14:49 11. Figures from the outstanding threads by @EllingUlrich and @yunlong_caohttps://t.co/EYv2j5wrVYhttps://t.co/58GWiHN9Ahthat suggest imprinting as at least part of the explanation for this observation https://t.co/s0H4G0Ehhx

2022-09-18 18:14:48 10. Is this because Omicron BA.1 is less immunogenic or because of imprinting (responding preferentially to 1st exposure strain)?Same pattern of reduced antibody response in mice (and humans) to BA.1 and BA.5 compared with ancestral https://t.co/OLJCIWdldP

2022-09-18 18:14:46 9. Let's zoom in further on these data (here's the fog part)The antibody response to Omicron BA.1 (geometric mean titer) was multi-fold less than against the ancestral strain for the bivalent or original booster https://t.co/15WrhxFGA6

2022-09-18 18:14:44 8. Yet the overall data to support the need for boosters is clearcut. What about the bivalent Omicron vaccine that matches up to BA.5 (and BA.4.6) that account for ~99% of American cases?The data for a BA.1 bivalent vaccine was published @NEJM 16 Sept https://t.co/3ZJXrOchHh

2022-09-18 18:14:43 7. More on lack of enthusiasm for new bivalent Omicron boosters (actual data to be released this week)https://t.co/cgfn3roAhb @NPR by @nprscottsimon @robsteinnews https://t.co/Vo6yJucG8K

2022-09-18 18:14:42 6. Today's NY Times front page https://t.co/cJOWj5pIzEby @jackhealyNYT @sharonNYT @amyyqin Reasons: lack of perceived benefit, reactogenecity side-effects, unaware, "it's over"I'll come back to "potent" subsequently https://t.co/tWjakyDUYi

2022-09-18 18:14:40 5. So why haven't the majority of even high-risk (age 50+) gotten a 2nd booster? Updated datahttps://t.co/YBz9U1MBA4 https://t.co/unpmxhLE2N

2022-09-18 18:14:38 4. There is also evidence that boosters help protect vs #LongCovid (point estimate 84% reduction for 3 shots in this cohort of health care workers)https://t.co/IAuQCZs6bl https://t.co/T33YZHq1VD

2022-09-18 18:14:36 3. The magnitude of benefit has been consistent over time, for different Omicron subvariants. Here in May, across all ages, H/T @redouad, 96% reduction of death for 4 shots vs unvaccinated https://t.co/oetnzuCikH

2022-09-18 18:14:34 2. The most recent @CDCgov data, compared with unvaccinated, age 50+4 shots: 94% reduction of death3 shots: 83.5% reduction of death https://t.co/ZXvVOKOhEb

2022-09-18 18:14:33 Lifting the booster fogThe evidence supporting boosters is incontrovertible. Summary of data for 4th vs 3rd shots for survival benefit, age 50+The unequivocal benefit is for enhanced protection vs severe Covid https://t.co/2Gpaxq8xlM

2022-09-18 15:19:13 @CarlHoefer1 @AlpertReyes @a1daylanan @mtosterholm Read the article

2022-09-17 20:49:26 This IS good news and aligns well with many prior report vaccination-mediated reduction (≥40%) of #LongCovid But to *prevent* this we need to block infections and transmission. As the virus evolved, that's unlikely to come from shotshttps://t.co/HqzfKW3JCk https://t.co/JiEAqC08T2 https://t.co/JUvJnk6ucm

2022-09-17 19:01:25 When hallucinating can be a good thing......"Our results highlight the rich diversity of new protein structures that can be generated using deep learning"https://t.co/085N9nDqFd @ScienceMagazine @UWproteindesign @BasileWicky #ProteinMPNN #AlphaFold #AI https://t.co/aVQe1uqeVN

2022-09-17 18:11:10 It’s “a landmark study in the treatment of autoimmunity” —Aimee Payne @PennMedicine https://t.co/QKkstwc7AL @ScienceMagazine @jcouzin

2022-09-17 17:06:26 This thread is rich with new insights about imprinting in response to BA.5 breakthrough infections (relative lack of nAb response), and for the BA.2.75.2 variant pinpointing the mutations that help explain its immune escape https://t.co/SzcTYViNKN https://t.co/0oUIdbJIlZ

2022-09-17 15:13:10 Here's the preprint by @BenjMurrell and colleagues now posted, summarized in his threadhttps://t.co/6kuQCL8AJs"BA.2.75.2 was neutralised...five-fold less potently than BA.5... These data raise concerns that BA.2.75.2 may effectively evade humoral immunity in the population."

2022-09-17 03:31:35 @MikeMadden Not to worry. It would take a couple of months for this one or an alternative to become dominant, even with exponential growth

2022-09-16 20:27:54 Independent replication BA.2.75.2https://t.co/AovxlrORTx

2022-09-16 20:17:10 This is one of the main BA.2 new variants to be concerned about, with real immune-evasive potential to outcompete BA.5 https://t.co/nE5OdNBYsl

2022-09-16 20:11:07 @BenjMurrell I'm with you on this, Ben. Very concerned about BA.2.75.2

2022-09-16 18:41:26 "if just 5% ultimately fulfill criteria for #LongCovid, that means 7.5 M individuals would be affected in the US. In comparison, each year in the US, ~1.8 M individuals are diagnosed w/cancer and 1.5 M are diagnosed w/ diabetes."https://t.co/SrtRtGsYCD@Health_Affairs https://t.co/fww1YTcF6o

2022-09-16 18:14:52 If it's a 1-pager, it's simple stuffhttps://t.co/jJ8SMZaS5R @CellCellPress @WickstromLab @WickstromLab https://t.co/n8K9L5LNJj

2022-09-16 18:06:22 The remarkably prominent and diverse role of macrophage cells in the heart continues to grow. A new, well done review @ImmunityCP https://t.co/kk9NYwIBVI by @rysa_zaman @EpelmanLab @UofT @uoftmedicine https://t.co/F6g5tdnQ5f https://t.co/gf4gAhupjb

2022-09-16 17:44:24 @berthacoombs Unfortunately, I think it's unlikely to provide longer (>

2022-09-16 16:54:41 Latest report of BA.2.75 https://t.co/kNqdzC0PiNAnd thread on prior oneshttps://t.co/awxz6JydTV https://t.co/t2SOHzrf0z

2022-09-16 16:40:20 BF.7 is BA.5.2.1.XBA.2.75 (spike mutations below, H/T @PeacockFlu ) isn't as concerning as further BA.2 derivatives BA.2.75.2 acquired 3 more key spike mutations, more immune evasion potentialNB: The virus is still showing substantial signs of evolution

2022-09-16 16:24:54 The latest US genomic surveillance data shows another small gain of BA.4.6 but, for the 1st time, past the 1% threshold of BA.2.75 and BF.7https://t.co/jjl2AnOYb5 https://t.co/HzwoPmIyre

2022-09-16 16:06:15 No differences in reactogenicity/safety between original and bivalent Omicron booster(this is an issue which needs to improve and discourages people from getting booster shots) https://t.co/vRFcIC3G18

2022-09-16 16:02:39 Just out @NEJM The bivalent ancestral/BA.1 Moderna vaccine as a 2nd booster vs original boosterhttps://t.co/tlZQSJaTTi~2-fold increase of neutralizing antibodies vs BA.1, BA.5, no effectiveness data https://t.co/FqHikImL19

2022-09-16 14:03:15 The danger of Covid vs fluFact-free viewshttps://t.co/dCZC9uqkS8 @NPR @robsteinnews Facts by @ProfPCDoherty https://t.co/lQoju88xDK https://t.co/Asua2czmBX

2022-09-16 13:50:25 It's exciting to see the powerful impact of CRISPR genome editing "In the low-dose group, the one-time infusion also reduced by 91% the painful swelling “attacks” commonly experienced by patients with a rare condition called hereditary angioedema"https://t.co/SfC6squo9G https://t.co/Qxl1kwVd56

2022-09-13 03:11:04 I posted an addendum to clarify misinterpretations that I have undervalued the profound contributions of human genomics.

2022-09-12 23:29:47 @MelissaServedio @SSI_dk @GKPedersen @eBioMedicine No.

2022-09-12 22:55:39 A Covid shot prime and nasal vaccine boost significantly reduced upper airway viral load and transmission in an experimental model, w/ perspective on other shot plus nasal vax booster clinical successhttps://t.co/wpaudojNbP @SSI_dk @GKPedersen @eBioMedicine https://t.co/lAsigX4DdX

2022-09-12 22:34:35 The protection derived from a 4th shot mRNA booster in ~40,000 people age 80+ in Singapore, compared w/ ~40,000 matched controls with 3 shots, during its BA.2 and BA.5 waveshttps://t.co/mHohjlT2lx @AnnalsofIM https://t.co/t6kpxAwnZp

2022-09-12 21:23:07 The road to cancer cures may go through the nervous system. An astute perspective on cancer-neuroscience interactions @NatureCellBio https://t.co/T4wEDD0O9B by @ChenchenPan1 @Winkler_Lab https://t.co/AGKX3CQP0z

2022-09-12 19:59:36 The paper was mistakenly put behind a paywall, which has now been corrected. Here's the link https://t.co/rYT7Hsf2jH

2022-09-12 18:17:03 A 2nd paper today with more results from this cohort on physical activity and cadence, specifically for association with cardiovascular and cancer events during follow-uphttps://t.co/qPenxKQoSO @JAMAInternalMed https://t.co/KElFmqRyga

2022-09-12 17:52:24 RT @DKThomp: This is really exciting: I'm talking to @EricTopol tomorrow afternoon in a live interview about the future of medical innova…

2022-09-12 16:11:13 A new and outstanding review of Covid/#SARSCoV2 in immunocompromised individuals https://t.co/51TMhVW1Kd @ImmunityCP @dewolf_susan @SantoshVardhana @MSKCancerCenter https://t.co/1UBQ9BzLiH

2022-09-12 15:45:49 From combining genetic data in over 730,000 people and 80 diseases burden estimates:"Genetic risk factors can explain a sizable number of healthy life years lost both at the individual and population level"https://t.co/ggljmkcmHG @NatureMed @andganna @DrSakari @FIMM_UH https://t.co/rUI1Ua3mIP

2022-09-12 00:57:50 RT @McFaul: Ukrainian warriors are humiliating Putin and his generals.

2022-09-12 00:40:00 The chasm between knowledge and practice needs to be addressed https://t.co/SU49gPt8RZ

2022-09-12 00:02:30 RT @mor10: "COVID is over" they say as the pandemic burns through the population making people sick, giving people chronic illness, killing…

2022-09-11 20:18:41 More than 20 years after the 1st human genome was sequenced, there's relatively little to show for it in clinical practice. https://t.co/NmbW8oqtLc

2022-09-11 17:14:28 I don't think so:"In a not-too-distant future, your Prime membership may include a free annual checkup."https://t.co/5Q8JeqlYPp by @david_wainer https://t.co/dOMwe7Fxgr

2022-09-11 16:22:29 Don't be numb to thishttps://t.co/t2x5LYfzZc by @jon_kamp https://t.co/qZlKRLrBdZ

2022-09-11 15:39:35 "The U.S. shouldn’t live with covid. It should get beyond the virus."https://t.co/u0USbACt9aOn annual shots working: "that is a massive if""The nation needs a massive push to create a universal coronavirus vaccine against all variants and for a long duration." https://t.co/5ABsPsdhoO

2022-09-11 15:19:18 The first organ transplant in the US was in 1954.Now there have been 1 million.105,000 people are on the waiting list.~17 die each day waitinghttps://t.co/5luRM9owWJ by @LNeergaard @APHealthScience https://t.co/zhMZXLJzoR

2022-09-10 22:40:42 "These findings highlight the need to develop vaccines that enhance nasal immunity."https://t.co/MkDNgpb6HT @FelicityLiew @p_openshaw @LanceTurtle @InThwaiteImmune and colleagues https://t.co/CXVvcVF3Yo

2022-09-10 19:28:25 RT @EricTopol: We'd never met someone w/ degrees in math, physics, history (2), and expertise in health data scienceProf Christina Pagel @…

2022-09-10 18:53:42 Superior antibody vs variants of concern and T-cell response for nasal vaccine (i.n.) compared with shots (s.c.)https://t.co/YmX3XHML6y @StJohnLab @dukenus @justsaysinmice https://t.co/VThK88lwSS

2022-09-10 18:24:48 And this by @maryhul @QZ is chillinghttps://t.co/dSjnHSMAr7 https://t.co/JCvF0acvg2

2022-09-10 18:24:47 Across the board, worst for Native Americanshttps://t.co/1antdOz14w by @germanrlopez @ashhwu @nytgraphics https://t.co/GkDVpAJZOW

2022-09-09 19:55:05 Does when you load calories during the day help with weight loss? A randomized, crossover trial says no https://t.co/pUJPMk7FUF @Cell_Metabolism https://t.co/bDmqe3f2iX

2022-09-09 19:23:06 We'd never met someone w/ degrees in math, physics, history (2), and expertise in health data scienceProf Christina Pagel @chrischirp is a leading information &

2022-09-09 18:38:30 Latest US #SARSCoV2 genomic surveillance: 89% BA.5, 9% BA.4.6Slow growth of the latter, ~1%/week, and overall decline in cases No other variants at appreciable levels https://t.co/cVICaeqetJ

2022-09-09 17:49:01 RT @chrischirp: Delighted to chat to @EricTopol and @cuttingforstone at length about maths, physics, history, my day job - and mostly - Cov…

2022-09-09 14:39:52 Hey, U.S., is this the best you can do?“At this point, we know another variant is coming — we just don’t know when,” a senior administration official said. “Our job is to make [the vaccine] available. And then people can do what they want.”https://t.co/1dK0FAoEUJ@adamcancryn

2022-09-09 14:14:49 The comprehensive list of validated treatments for ME/CFS and #LongCovid.This has to change. https://t.co/qW2wMapwVq

2022-09-09 14:03:33 In this thread, @chrischirp provides a useful summary of the responses for each of the 6 salient topicshttps://t.co/NbESV9XOIG

2022-09-08 23:11:36 A single amino acid change helps explain our cognitive power compared with Neanderthals!https://t.co/MnvqZxeyVwhttps://t.co/iJ5etwtnsI@ScienceMagazine And a @carlzimmer explainerhttps://t.co/njk0bQqbt6 @NYTScience https://t.co/Gq1NwEaboZ

2022-09-08 22:38:50 RT @ProfPCDoherty: It's important not to 'push through' with high level fitness activities if you've had mild COVID and, months later, your…

2022-09-08 19:12:37 As opposed to what is generally thought (from under-reporting sequence variation of Covid samples)......"Our study has revealed significant within host infection diversity of #SARSCoV2 through full genome sequence analysis."https://t.co/22Ab1H4dl0 @PLOSGenetics https://t.co/mErDXuNoCZ

2022-09-08 18:24:57 Quite the @ScienceMagazine feature on Covid and children with key questions and insightshttps://t.co/OpTu7vWJlG@AldertonBiol w/ @chrischirp @dgurdasani1 @BinitaKane @carlpierce @PeterHotez @sarahcobey @scotthensley https://t.co/JpDwJTqRM8

2022-09-08 18:07:08 Full text here https://t.co/vtrwAWD9kF

2022-09-08 18:07:06 Excellent, succinct review of myalgic encephalomyelitis (ME/CFS) and its overlapping features with #LongCovid @ScienceMagazine https://t.co/CipzsAdv2r https://t.co/nSAfeCU9eL

2022-09-08 16:43:49 Missed opportunities in the U.S. The intellectual property for multiple Covid nasal vaccines was licensed to companies in other countries, such as that of @WUSTLmed to @BharatBiotech https://t.co/YrV9ojPWpH https://t.co/clrbrUUDiQ

2022-09-08 16:36:06 Seeing the invisible by expansion microscopy and #AI intelligent microscopy https://t.co/vo88mCIQMS@TheEconomist @eboyden3 https://t.co/l9leXjhDAk@naturemethods @SulianaManley @EPFL_en https://t.co/HD3uLt2FNg https://t.co/KyXAhqOX49

2022-09-08 14:52:09 New research initiative on #LongCovid root causes @research_long @polybioRF @microbeminded2 https://t.co/8BCJXXeL9D@rddysum https://t.co/Olx9gDzUYK @lukemmoney https://t.co/VxAMtM0dgb

2022-09-07 23:00:36 More on the risk of artificial sweeteners ascertained through a large (>

2022-09-07 22:10:07 2 more reports characterizing BA.2.75https://t.co/0Q16FPfXw4 @cellhostmicrobe https://t.co/jt1p9uuLUv @NEJM But the concern is now shifted to BA.2.75.2, which has acquired 3 more key spike mutations, more immune evasion, see @PeacockFlu &

2022-09-07 21:44:34 @JaneEspenson @NEJM Yes, for sure, in high-risk people. There is no question of Paxlovid's high efficacy—protection vs hospitalizations and deaths—despite the occurrence of rebound in some (per cent still unknown) people

2022-09-07 21:19:47 How well does an original (ancestral strain) mRNA booster hold up vs BA.5 over time for neutralizing antibodies?https://t.co/W00tJM8bZW @NEJMNot well, especially in people without breakthrough or prior infections https://t.co/S08OQzpRSJ

2022-09-07 21:11:56 A small, in-depth study of Paxlovid rebound demonstrates high viral load with symptoms or positive antigen tests—which supports infectiousness— along with occurrence in 5 of 13 families, suggesting it is not uncommonhttps://t.co/Zqz8kaZpT4 @NEJM https://t.co/ot8yVTTu3G

2022-09-07 16:56:50 Why do people have a high affinity to fat in their diet?https://t.co/VwqKEDhZF8Discovery of a gut-brain axis with distinct cells and receptors for fat perference, not indexed to taste@ColumbiaMed @nature @justsaysinmice https://t.co/Iux0q2jmQR @HHMINEWS https://t.co/G48CUANIDc

2022-09-07 14:40:16 @cshperspectives This adds to where we stand now in [not] protecting Americans who are immunocompromisedhttps://t.co/6xoOO1MbZH https://t.co/lxySNXBi5b

2022-09-07 13:50:27 A new report confirms BA.4.6's (now ~10% in US) immune escape, loss of Evusheld sensitivity"The loss of activity of tixagevimab and cilgavimab against BA.4.6 leaves us with bebtelovimab as the only therapeutic mAb that has retained potent activity"https://t.co/6zIY01Fi0w https://t.co/pJE1BfaHnW https://t.co/IJ2RkH1Eow

2022-09-07 13:31:53 @yunlong_cao @CorneliusRoemer @chrischirp @TheLancetInfDis @BenjMurrell @PeacockFlu @DannySheward Quite concerning. Look forward to reviewing the data Thank you

2022-09-07 02:25:34 What is the prevalence of #LongCovid with the BA.5 variant? A new report from US, June-July, w/o controls, is the first crack at the question: 21.5% had symptoms >

2022-09-06 22:39:03 More good news on BA.2.75, replicating and extending the prior (attached) reporthttps://t.co/duCTPI7c5s"antibody escape is an overall less pronounced characteristic of BA.2.75 compared with BA.4/5"@TheLancetInfDis https://t.co/9SszCrYNkB

2022-09-06 22:21:21 @FlyingFish06 @GradyMcGregor @cansinobio_inc It was there, now removed. The author, @GradyMcGregor, should respond

2022-09-06 21:59:32 @lexbyanyname @leozh @HMogan24 @scottshanno @loriand95467435 @lehudgins Yes, the lowest estimate was 15% reduction, from this reporthttps://t.co/2JUuTatett

2022-09-06 21:47:18 The U.S. hasn't really even tried https://t.co/OEhpuFFenL by @GradyMcGregor Meanwhile 1 breath of @cansinobio_inc's inhaled vaccine booster was better than a 3rd shot vs Omicron for neutralizing antibody response (92% vs 0%) at 4 weeks

2022-09-06 21:31:45 @CarlosdelRio7 on "boosting our way" out is untenable, but to give a false impression of year-long protection (vs severe disease and death) with the data in hand is not acceptable. There are multiple ways this can be achieved, and the US is not actively aggressively pursuing any of them.

2022-09-06 19:43:34 I've previously addressed the vital need for variant-proof &

2022-09-06 18:50:25 Just tweaking the lipid nanoparticles could make a big difference"There is still so much optimization and development that needs to happen"—@AnnaBlakney "There's a huge amount of RNA that's not being used"—@sahayg1https://t.co/Q3wiygjRcd by @ElieDolgin @ScienceMagazine https://t.co/3ZT4fOkNeo

2022-09-06 18:24:35 This has the ring of Covid capitulation https://t.co/9boHwQ6nYiI'm certain we can do better than this. The science foundation is there for multiple paths of extended durability and enhanced protection. The will is not. https://t.co/iBMu0mcqRa

2022-09-06 18:12:59 @Laurie_Garrett Agree, Laurie

2022-09-06 17:40:44 I don't see any evidence for how an annual Covid shot will provide durable protection (current ones wane after 4-6 months) without better vaccines, such as variant-proof, improved nanoparticles, and nasalhttps://t.co/uytgskKKN9 https://t.co/knjhSjNELL

2022-09-06 16:51:28 Discovery of new antibiotics is critical to deal with the resistance issue. Hope this would be accelerated with the use of #AlphaFold is tempered by this new @EMBOPress report https://t.co/rydDsMeE6v by @MIT_IMES @MITdeptofBE https://t.co/BVqn1gh69n

2022-09-06 16:34:35 @HenrikVogt Wrong. You have completely misinterpreted and twisted what I wrote. I simply pointed out that the symptoms of the Yale/Mt. Sinai study participants tracked tightly with the multiple molecular biomarkers they assessed.

2022-09-06 15:05:31 The link between physical activity (steps) and avoidance of dementia A new @uk_biobank study of over 78,000 people showed largest decrease for >

2022-09-06 14:10:54 Timely feature @Nature : How nasal spray vaccines could change the pandemic https://t.co/R9xcvCe0qlby @EmWaltz https://t.co/ml8tfxUOVB

2022-09-06 13:32:35 Nasal and oral vaccines are our best shot to block infections, transmission, achieve containment of the virus, reduce the toll of sickness, &

2022-09-05 16:47:04 RT @VirusesImmunity: Very happy to see that China approved the world’s first inhaled vaccine against COVID-19. Convidecia Air is an aerosol…

2022-09-05 16:43:38 First inhaled Covid vaccine approved, with improved Omicron antibody response as booster to 2 shots (Coronavac) compared to 3 shots https://t.co/3MtEgb7Rro by @GradyMcGregor

2022-09-05 16:22:25 @HoffmannJedrzej @NatureMedicine @v_puntmann @AShchendrygina @c_eike @AndreasZeiher @GoetheCVI Such an important study to help us understand cardiac implications and ties to symptoms during extended follow up in a selected cohort of mild Covid, with controls. Thanks to you and your colleagues

2022-09-05 15:27:18 The main symptom was difficulty breathing with exertion

2022-09-05 15:13:51 "The imaging findings suggest that inflammatory cardiac involvement after COVID may be a pathophysiological commonality shared among all individuals, regardless of the expression of cardiac symptoms" https://t.co/NuA9h9CXIL

2022-09-05 15:13:49 @NatureMedicine Heart manifestations of #LongCovidA prospective MRI study of 346 people with mild Covid, and controls, demonstrated myocardial inflammation at 3 months, worse w/ symptoms, and edema at ~1 yearby @v_puntmann and colleagues @GoetheCVI https://t.co/TjrAJphYCh https://t.co/RxlRyHCcZ1

2022-09-04 19:54:22 Entry of #SARSCoV2, with viral membrane fusion and transfer of the genome to the cytosol of the cell. Requires an acidic pH (nasal pH in 17 healthy participants was 6.6)https://t.co/As5p6jg7JO@PNASNews https://t.co/7LoyTJyCf0

2022-09-04 18:18:08 Vaccine breakthrough infections teach us about the upper airway T-cell immune response, its durability, and hybrid immunity. Yet another indicator of what nasal vaccines could achieve instead of breakthrough infectionshttps://t.co/12cocEJ8MK @JExpMed by @bertoletti_lab https://t.co/XYkPrD9KA3

2022-09-04 00:45:15 @LongDesertTrain It's certainly possible, Ryan. Which is why I wrote "several" instead of "many" weeks respite and emphasized variant-chasing isn't the right strategy.There's also the BA.2.3 you've spotlightedhttps://t.co/ez2XHPwhPX

2022-09-03 19:29:07 The new bivalent boosters are already available in many drugstores around the country. The BA.5 spike protein mRNA comprises 15 μg for Pfizer and 25 μg for Moderna https://t.co/mf2Leop05q

2022-09-03 18:51:22 The new bivalent BA.5/ancestral booster may help restore that and could also improve protection vs infections and transmission. But we won't know that for several weeks /5https://t.co/BR54il19st

2022-09-03 18:51:21 What is concerning to me is to see the decline in vaccine effectiveness vs hospitalizations for BA.5 compared with the prior Omicron subvariants /4https://t.co/64b9g7HW1h https://t.co/7fzohLYZ7X

2022-09-03 18:51:20 Please be aware there's still lots of circulating virus, ~90% of which is BA.5 out thereOnly BA.4.6 is slowly competing at an appreciable level, recently ~1% growth/ weekLatest transmission map /3https://t.co/S0JGpwehtc. . https://t.co/v0bcuHFCZH

2022-09-03 18:51:18 The US metricsExcept for deaths that remain at a ~500 deaths/day plateau, all are pointing in the right directionCases are notoriously under-reported, but we are at the lowest level in 4 months, (that number of confirmed cases, 78K, is still very high) /2 https://t.co/BYmoS9p3IH

2022-09-03 18:51:17 The BA.5 variant wave is in descent in the US and throughout the world. Without a threatening new variant that exhibits ability to strongly compete now, we should have several weeks of a respite World cases/ deathsJapan, one of the last to get hit, still on the rise for deaths https://t.co/pq4fkpYEoF

2022-09-03 16:49:29 The involvement of endothelium, the lining of blood vessels, is an important underpinning of #LongCovid's pathophysiology. An impressive review paper @jclinicalinvesthttps://t.co/TYLx2ZsZZF https://t.co/w1OMf3Y2ah

2022-09-03 01:16:54 @CarlosdelRio7 Yes, Carlos, because it has no real competition. That may be good, and help us avoid a new wave for many weeks. I don't want to see a variant that can rapidly out-compete BA.5!

2022-09-02 20:57:18 Very good #LongCovid review of what's known on mechanism, sequelae and treatments. One edit from me on the title https://t.co/Rs6Filotob@PNASNews by @LeahabShafferWe urgently need to get treatments validated https://t.co/F5XvBrAIof

2022-09-02 18:44:06 One of the big biomedical advances this year was the report that multiple sclerosis is caused by the Epstein-Barr virus. A new essay @jclinicalinvest says not so fast, the strong evidence was restricted to one grouphttps://t.co/1xmbTJV1DV by @ihorwitz@Idasim and colleagues https://t.co/bO0LTBUyx6

2022-09-02 18:15:06 @AWeissmann_ Somehow "classified" and "empty folders" doesn't seem to go together very well

2022-09-02 17:27:56 "Our study demonstrates an unexpected role for GnRH [gonadotropin-releasing hormone] in olfactory &

2022-09-02 16:23:35 some more on backgroundhttps://t.co/ApmNy5w7S6

2022-09-02 15:11:20 BA.4.6 (in blue) shows a lot of regional variation https://t.co/BjcE3uJrev

2022-09-02 15:11:18 Latest US genomic surveillance data posted shows BA.5 at 89%, BA 4.6 at 8.4% (slow growth) and no detection at appreciable levels of a new variant https://t.co/jjl2AnwOWX https://t.co/CNV3zZfjft

2022-09-02 14:41:29 To efficiently block Covid infections and transmission, we need to get high levels of secretory IgA, reflecting mucosal immunity. Important work by @florian_krammer and colleagues

2022-09-02 14:16:00 "Equivalent of a James Webb Space Telescope for biology," now predicting 3D structure of >

2022-09-02 01:57:48 An indefatigable force throughout the pandemic, @trishgreenhalgh goes deep to understand the big miss—that #COVIDisAirborne https://t.co/erqAF4iAiB@BMJ_latest w/ @DRTomlinsonEP and Mustafa Ozbilgin https://t.co/i5oX0kQw2Z

2022-09-01 23:06:56 Sone good news about the BA.2.75 variant, in case it gets legs: it's not more immune evasive than BA.5, has cross-immunity w/ BA.1/2, and is still sensitive to Evusheld and Bebtelovimabhttps://t.co/EgnyuWpCYm @TheLancetInfDis @BenjMurrell @PeacockFlu @DannySheward &

2022-09-01 21:03:26 "A Gut Reaction" A nice explainer published today @CellCellPress on this important study https://t.co/YC9RqQx7XC https://t.co/gUKqe42NWr

2022-09-01 17:30:08 Some slippage of vaccine protection vs BA.5 hospitalizations is concerning, reflects its immune escape, and there's hope for bolstering by the new boosters. As previously noted, it ought to prompt aggressive efforts for pan-sarbecovirus and nasal vaccineshttps://t.co/vwK1ZXsU7m

2022-09-01 17:01:20 Aligns with this @nature summary and perspective of a recent analysis by @DebCro @KirbyInstitute that suggests there may be little difference between the 2 bivalent vaccines (BA.1 v. BA.5) https://t.co/iqA2L2qPp7https://t.co/cejMclUDLu by @ewencallaway https://t.co/JW5uEcYvth

2022-09-01 16:18:26 Data also presented for protection vs BA.5 symptomatic infection for age 50+ (by booster dose and over time) https://t.co/lr1mzJulKq

2022-09-01 15:50:26 New data at today's CDC/ACIP meeting on vaccine effectiveness vs BA.5 wave hospitalizations, all adultshttps://t.co/64b9g7HW1hLess protection for both 3rd and 4th dose vaccines compared with the prior wave (BA.2, BA.2.12) https://t.co/JTichjw2I3

2022-09-01 15:36:55 And in mouse model challenged with BA.5 virus, similar impact for the 2 bivalent vaccines, better than original (ancestral) vaccine https://t.co/syanLPV1ni

2022-09-01 15:36:54 First look at BA.5 bivalent booster vaccine data from @moderna_tx, only in mice, at today's ACIP meetinghttps://t.co/8cZMlkWCmuNeutralizing antibody response similar to BA.1 bivalent vaccine https://t.co/g6KuRGt0pM

2022-09-01 01:59:32 RT @MaryPeltola: My position on the right to choose is simple: our government should not be in the business of telling people what they can…

2022-08-31 23:23:56 @pelagicbird @GretchenVogel1 @ScienceInsider @ScienceMagazine @lauriemcginley2 @washingtonpost @PostHealthSci Correct. I pointed that out too and still do not understand why we aren't going vs BA.5 only https://t.co/BR54il19st

2022-08-31 23:22:09 There's one country that doesn't get what it pays for, which preceded the pandemic https://t.co/7PaLGyglVTNow >

2022-08-31 22:36:50 Congratulations to @yuwang_15 for this groundbreaking workAnd the —seeing is believing—video https://t.co/W05gz13l7B

2022-08-31 22:29:56 Good to see for JapanStart of BA.5 wave descent for fatalities @OurWorldInData Japan has one of, if not the, lowest cumulative (and excess) mortality rates of large population countries in the world with rigorous tracking https://t.co/W1GR7Jdmtp

2022-08-31 22:09:12 @molly_knight @doctorsoumya @MommasGoneCity Thanks for sharing the horrible ordeal of what you're going through and so glad you're seeing some improvement. POTS is real as a #LongCovid serious sequelae, despite the denialism out there, and vaxx/boosters cannot be relied upon to protect

2022-08-31 21:27:32 A new, very good Covid vaccine review article @NEJM https://t.co/xglkQ5HQCO by @BarouchLab "Current Covid-19 vaccines are less effective at blocking infection with the omicron variant than ... prior variants, but protection against severe disease remains largely preserved." https://t.co/APj8UwoK6f

2022-08-31 21:01:28 Full text and table from supplemental for context https://t.co/tMVa93K8ga

2022-08-31 21:01:26 A Portugal nationwide study shows prior infections with BA.1 and BA.2 protects better vs BA.5 than earlier major variants, in a highly vaccinated population https://t.co/JuxIzrDZIFThat's good since previous data was unclear for BA.1/2 and there were a lot of these infections https://t.co/bfzrI5sk8B

2022-08-31 16:54:32 2 helpful articles on the questions surrounding the new boostershttps://t.co/K9RGJb7N8g by @GretchenVogel1 @ScienceInsider @ScienceMagazine https://t.co/eRibjK3CsU by @lauriemcginley2 @washingtonpost @PostHealthSci https://t.co/BOSWMCv9kM

2022-08-31 16:39:42 How fat tissue talks to the brainThe dogma was it occurred slowly through hormones. Now there's proof it occurs rapidly through neurons.https://t.co/Uh1c3L1rWtby my colleagues @scrippsresearch @liye_tsri@ardemp @Nature https://t.co/RDw6l8xeLf

2022-08-31 16:19:18 @Nature On autoimmune features of #LongCovid "..autoreactivity persists in a subset of patients w/post-acute sequelae, raising important questions...emerging autoreactivity to ongoing symptomology upon recovery"https://t.co/xyGIqRQYrkExtrapolated via patients w/severe Covid https://t.co/Hv43gMERvC

2022-08-31 16:03:13 Relevant to new BA.5 boosters for people with recent infection <

2022-08-31 14:19:14 No surprise hereBut it’s not a straightforward decision https://t.co/BR54il19st https://t.co/iB7SZa4Ns4

2022-08-31 13:42:53 This precipitous drop and current level is substantially worse than 21 peer countrieshttps://t.co/NAEMjhs4j3 https://t.co/QhrZ1Xnwcr

2022-08-31 13:38:27 That's one way to counter Covid mis/dis-information from doctorshttps://t.co/bE5XVLgI4m @stevenleemyers https://t.co/0YSyJL1u2f

2022-08-31 12:50:05 The historic drop in US life expectancyBiggest two-year decline —2.7 years in total — in almost 100 yearsNow 76.1, the lowest in 25 years Levels at 1944 for AIANPandemic, accidents and overdoses were 1° drivershttps://t.co/0Z9TQIIXRwhttps://t.co/3iFlziN2Xk https://t.co/relDFO7Xhb

2022-08-31 03:52:05 @kyledcheney a picture worth a thousand(s) of [secret] words

2022-08-31 00:34:50 A digital, site-less, smartphone app, randomized clinical trial detected more than 2-fold atrial fibrillation warranting blood thinners compared to usual carehttps://t.co/HCCCfLXfQs@NatureMedicine https://t.co/u6TTkByW1M

2022-08-31 00:01:16 @CatchTheBaby @StephenAtHome Thanks Ruth Ann! Not sure how I goofed to get the link wrong

2022-08-30 23:47:49 RT @JusDayDa: @EricTopol @OurWorldInData Last 12 months... https://t.co/rk4bWpb7pU

2022-08-30 21:41:50 A colleague just sent me this video segment I did with @StephenAtHome from nearly a decade ago. It brought back some fun and funny memories https://t.co/Dc0gRFET3B

2022-08-30 21:18:51 @Andr3wW1l3s @acweyand Deeply appreciated

2022-08-30 20:14:44 Missed RussiaThanks for spotting @Dr_Rezaee https://t.co/XNT7S8MPNr

2022-08-30 20:03:18 Pandemic mortality over the past 12 months, outliers, per capitaOnly Greece and Hong Kong fared worse than the United StatesJapan (even w/ BA.5 wave that has doubled cumulative deaths), UAE, Qatar are among the lowest fatality ratesvia @OurWorldInData https://t.co/U2gtBX8H98 https://t.co/hJJf9EpwGw

2022-08-30 18:35:47 The term "accessory genes mutations" is used to denote those outside of the spike"We interpret these data as suggesting that mutations outside of spike may be driving critical phenotypes of #SARSCoV2 infection and disease"Nice work by @mcgrath_marisa @MattFrieman and colleagues

2022-08-30 18:35:46 The spike-centric thinking of #SARSCoV2 does not take into account pathogenic mutations outside the spikeA report documenting potential importance of ORF3a/b and ORF8 in vivo, known to affect our innate immune response (IFN, 1st line of defense)https://t.co/d0xXiXGzBI@PNASNews https://t.co/X4f0MoftDp

2022-08-30 17:10:41 Good to see steady, albeit slow decline in US Covid hospitalizations, now less than 37,000But still nearly 3-fold that of April 2022's lowest point (metric definition hasn't changed) which should be attainable, at the leasthttps://t.co/7N96LQP0Dm https://t.co/im2u98ovUI

2022-08-30 13:53:42 On the after-effects of Covid, beyond and including #LongCovid"Covid generated a kind of epidemiological aftershock by leaving people susceptible to a huge range of other conditions"https://t.co/Tr9eFjnovw @FT by @SarahNev @federicacocco https://t.co/S2JNYobrhL

2022-08-28 15:39:31 This headline will not induce public confidence in the BA.5 boosters, with 175 million doses purchased https://t.co/v68wV79fVQIt may well turn out to be the right call, but there are many uncertainties, superimposed on poor US booster uptake, discussed https://t.co/BR54il19st https://t.co/rJvS1gYi69

2022-08-28 14:42:35 On the need for physician validation and empathy https://t.co/qIAunN252B

2022-08-28 14:42:33 The brain and #LongCovid https://t.co/kRS3MLXK5F a 5 summary by @WesElyMD Evidence/paths ->

2022-08-27 22:46:22 What's a variant-proof, universal vaccine?Our @scrippsresearch team put together a 2 minute video explainer https://t.co/hjfXoVj70G https://t.co/FNwI992VyP

2022-08-27 19:57:04 I reviewed the data herehttps://t.co/BR54il19st

2022-08-27 19:57:03 Why to make of the BA.5 boosters coming soon?The range of opinionshttps://t.co/9pXvgEs554 @LNeergaard @AP @Latimes @US_FDAhttps://t.co/QN03vrWJm4 @AliceParkNY @TIME @DrPaulOffit https://t.co/uNcejx0EFp

2022-08-27 18:40:41 Using RNA sequencing from tissue biopsy and #AI to discover, validate, and quantify Covid vascular inflammation (called C19-RS) from CT scans, linked with clotting and adverse prognosishttps://t.co/xJIaDGseKm @LancetDigitalH @escardio #esc2022 https://t.co/QL7Qf53KQ4

2022-08-27 18:23:20 If you're a man 65 to 74 years old, should you have cardiovascular screening including a CT scan calcium score, ankle-brachial index, AF, blood tests for LDL and diabetes?A large randomized trial with 5.6 year follow-up showed lack of benefithttps://t.co/HFMXfyeN8c @escardio https://t.co/2jOgxOLAnQ

2022-08-27 17:28:39 Relevant statements from the reports of these 2 trials https://t.co/fcZn7G56tx

2022-08-27 17:28:37 No.Ad in @NYTmag for a dietary supplement (Urolithin A) that costs $200/month and claims to be "clinically proven to renew mitochondria"2 small clinical trials cited, called ENERGIZE and ATLAS, conducted by the companyhttps://t.co/I10jupjXYQhttps://t.co/zzWJnGgAs8 https://t.co/8Hhmv33XBz

2022-08-27 16:30:19 Wrist sensors can help in early diagnosis of Covid/viral illness and may also be useful in managing #LongCovid, @TheLancet with @julialmv @ScrippsRTI and @RobertHirten @IcahnMountSinai https://t.co/KUhmHg3U28 https://t.co/MMIftkHcwo

2022-08-27 16:05:53 A bit of contrast https://t.co/TWWeKVLyxP

2022-08-26 19:35:38 @AstroKatie Agree, Katie. It's unpredictable. But I wouldn't have expected these findings in 20-year-old healthy soldiershttps://t.co/Z9WNhhNuJj

2022-08-26 19:19:47 While it isn't large, this is one of the most comprehensive #LongCovid prospective, w/controls studies yet. Not assessing mechanistic data (like immune response, persistent virus) but insights about enduring multi-system sequelae in a cohort that would be considered very low risk

2022-08-26 18:56:44 A prospective study of #LongCovid in young (median age=21), healthy, males (93%), with controls: "new evidence that even infections in young adults can lead to sequelae that persist several months"https://t.co/379fy4HmMW https://t.co/mp8METJrE6

2022-08-26 18:01:33 If you're into the impact of circadian rhythm and sleep on health, you'll find this new review @NatureRevGenet quite informative https://t.co/7avEroBCA4by @jlane_boston @SusanRedline and colleagues @BrighamWomens @broadinstitute https://t.co/4i560J0JPi

2022-08-26 16:26:25 This week's US genomic surveillance update BA.4.6 growth competing vs BA.5, slowly, most pronounced in one region (7)No other new variants at appreciable levelshttps://t.co/jjl2AnwOWX https://t.co/4O66l736Ld

2022-08-26 15:45:31 @SKDitta Much appreciated!

2022-08-26 15:29:49 Vaccines and boosters during the Omicron wave in Singapore, among >

2022-08-26 15:07:15 Consistent w/ the idea that "vaccine absolutism" (term from @SaskiaPopescu) won't cut itIn https://t.co/aGyvgFdoRO by @KatherineJWu

2022-08-26 15:02:22 "Most importantly, we need to achieve containment of the virus once and for all, and should not rely only on just the BA.5 booster." https://t.co/BR54il19st

2022-08-26 13:46:05 RT @Aiims1742: Nicely done! #OpenAccess in @NatureCancer:Cancer vaccines: the next immunotherapy frontierhttps://t.co/an3fahkaPE https://…

2022-08-26 06:05:31 How life expectancy in the United States "fell off a cliff"https://t.co/avXRtbg22T by @jburnmurdoch https://t.co/x6t4ZkSr8K

2022-08-25 22:55:16 "COVID-19 sequelae: can long-term effects be predicted?"No. That's the problem. #LongCovid cannot be predicted.https://t.co/eEy4EbtGqo @TheLancetInfDis

2022-08-25 21:52:49 RT @HandNF: "It’s actually striking that in 2 months from the June 28th FDA meeting, there is a BA.5 vaccine booster made at scale. That is…

2022-08-25 19:02:17 If you look at the spike mutation map for BA.5 and compare it to Alpha, the first major variant, it's striking how well vaccines have held up vs severe disease, and not surprising why it has been harder to suppress infections and spreadhttps://t.co/BR54il19st https://t.co/NMKx7mWadd

2022-08-25 17:45:57 The rate of asymptomatics for current infectious disease of interestPolio ~70%https://t.co/wCrxFSSscn.Covid ~30%https://t.co/SaD7D9WGS9Monkeypox ?% (cases documented)https://t.co/uQiXzPNGCN

2022-08-25 17:21:06 @katecrawford @AlondraNelson46 Yes, I wish it started right away instead of 2026

2022-08-25 16:21:52 Now replicated. Synthetic embryos in mice from embryonic stem cells https://t.co/dgJazenrWihttps://t.co/3o07C96ybIhttps://t.co/3wcakSd55B“The next milestone in this field very likely will be a synthetic stem-cell based human embryo”

2022-08-25 15:58:31 Gene therapies, the potentially curative "miracles of medicine," are hitting stride with 40-50 expected to be approved by 2030. But their up front costs remains a formidable challenge, despite favorable cost-benefit analyseshttps://t.co/tcT4bBLOaN https://t.co/p9GUXhQxen

2022-08-25 15:04:41 Important on #LongCovid —@BrookingsInst report on loss of ability to work and the financial tollhttps://t.co/VvFAlvpiNe by @kathrynsbach —"A whole new approach is needed"https://t.co/m6OEFrJkXs by @zeynep @nytopinion https://t.co/T4uyer0zqS

2022-08-25 14:50:50 Pre-bunking to fight against misinformation. Validation via 6 randomized trials using scalable videoshttps://t.co/B2cVrGHjHQ by @ScienceAdvances @roozenbot @Sander_vdLinden @_BGoldberg@steverathje2 @STWorghttps://t.co/cyMNJrik47 @nicoagrant @tiffkhsu https://t.co/TG6h3hX2IQ

2022-08-25 01:33:33 What we know and don't know about the BA.5 booster rolling out for all Americans age 12+ in ~2 weekshttps://t.co/BR54il19st https://t.co/5nF85lOnVq

2022-08-24 23:37:16 RT @PeterHotez: Pretty important thread from @EricTopol my take: despite the rebound, unpleasant minor side effects (metallic aftertaste+ s…

2022-08-24 22:53:39 Also published today, during the BA.2 wave in Hong Kong, among hospitalized patients without need for oxygen supplementation, early Paxlovid use associated with a 66% reduction of death compared with matched controlshttps://t.co/I8pG2RIFm8 and reduction ~50% with Molnupiravir https://t.co/3yimLea69Z

2022-08-24 22:32:50 @davidakin Thank you!

2022-08-24 22:24:58 @mdhhsu read the post to find out

2022-08-20 02:26:35 New CDC data on Covid deaths, age 50+, posted today, vs unvaccinated2 boosters: 94% reduction of death1 booster: 83% reduction of deathhttps://t.co/HGyjNwCm0vCurrent 2 boosters in USage 50-64: 11%age 65+: 26% https://t.co/L7OVsysrmB

2022-08-20 00:51:06 RT @SciImmunology: A new Editorial by @EricTopol and @VirusesImmunity calls for an accelerated initiative for nasal vaccination against #SA…

2022-08-19 20:04:12 This accompanied original research by @Jie_Immunology @ImmunologyTang @UVAImmunology colleagues https://t.co/kbV1dEJOK6Robust sterilizing respiratory tract immunity (BAL) from a nasal booster vaccine in the murine model, not seen with shots in people, including vs Omicron BA.1 https://t.co/n3kBAv8qh4

2022-08-19 19:23:52 "We urgently need to achieve population-wide respiratory mucosa immunity" to break the chain of transmission of Covid and achieve containment of the virusOur Operation Nasal Vaccine essay published @SciImmunology today https://t.co/OujfFxvdS6 an honor to work w/@VirusesImmunity https://t.co/eBHW3dRLMI

2022-08-19 18:09:55 @andkg @robsteinnews @NPR @NPRHealth @Nature @heidiledford Let me be clear. BA.5 ≠ influenza. It will be the 1st vaccine to go out at scale in the US since the original. There are no data for nAbs to BA.5 vax in humansWe don't even know if it will provide better clinical protection. There is no rush. Such data can be obtained in weeks.

2022-08-19 17:26:45 It was nice knowing you, US universal healthcare (light) for Covidhttps://t.co/UnCGPibWWU by @StephArmour1 https://t.co/NiCMWaaQVk

2022-08-19 17:13:36 Which &

2022-08-19 15:35:56 The skinny on non-nutritive sweeteners (they are not inert) via a randomized trial &

2022-08-19 14:41:35 What do high-demand cognitive work and chewing have in common? Energy sinks.Cognitionhttps://t.co/dFejfKmHwV @CurrentBiology Chewing https://t.co/zDIVuUnJtY@ScienceAdvances https://t.co/Kg96fdv4wg

2022-08-19 14:20:21 A new review of the T cell immune response from Covid infections, vaccines, and combined effect (hybrid) https://t.co/jWgo1smo3M @Anto_Berto @bertoletti_lab @ImmunityCP https://t.co/mG65sipeGt

2022-08-19 02:54:45 This isn't what "Living With Covid" was intended to mean https://t.co/Q1UV8aJrfF

2022-08-19 01:41:44 A high-resolution study of length of mild Covid infectiousness with virus culture and viral RNA load2/3rd of cases shedding virus, still infectious at 5 days post-symptom onset

2022-08-18 20:18:29 Fixed annotation, sorry https://t.co/KGA6ue9lxn

2022-08-18 20:16:21 US Covid hospitalizations are at a plateau ~40,000, which is ~4-fold where we were in April this year.Likewise, deaths are at ~500 each day, and confirmed cases still hover about 100,000 per day.This is not what containing the virus looks like. https://t.co/rh9ja8SKNK

2022-08-18 19:55:17 Full text here. One point I'm a bit at adds with:There has been some reduction of vaccine/booster protection from severe disease with variants, although it's still high (75-80%). Prior to Omicron and subvariants it was >

2022-08-18 19:06:34 RT @_Eric_Reinhart: My short piece this week builds on @EricTopol's 2019 essay in @NewYorker, and also what has been an unsurprisingly larg…

2022-08-18 18:01:25 A super summary on the pivotal role of T cell immunity in response to Covid vaccines @ScienceMagazine w/ @ScienceVisualsby @EJohnWherry and @BarouchLab https://t.co/GHng2HSEuL https://t.co/1CUt9KJUjl

2022-08-18 17:22:12 Only 30% of American children age 5 to 11 have thus far been vaccinated. A new @CDCMMWR of >

2022-08-18 15:41:26 Japan ranks 4th in the world for boosters, the US ranks 71st https://t.co/gWCbSb6EfDJapan's cumulative deaths per capita is 1/11th of the USYet BA.5, with its very high level of immune evasion, has challenged its immunity wallhttps://t.co/pQYFuqy954 https://t.co/NOLCYRykdI

2022-08-18 15:26:08 The ability to take on #SARSCoV2 variants can be greatly facilitated by improving nanoparticles A superb review @NatureNano https://t.co/34JnqDMZ8cBut it's science advances sitting in labs, not getting done at large to get ahead of the virus https://t.co/ZzQ8LFJ7eu

2022-08-18 15:10:45 @TRyanGregory @_TheAncientOne_ @OurWorldInData Japan's management of the pandemic has been exemplary

2022-08-18 14:25:08 Variants in Japan over time https://t.co/JzRj8Tkor8

2022-08-18 14:25:07 Japan's BA.5 wave deaths are now higher than any previous variant and still rising sharply @OurWorldInData https://t.co/2ZM3hEuN4t

2022-08-18 14:16:43 This would be a mistake"For the first time, the FDA is planning to base its decision about whether to authorize new boosters on studies involving mice instead of humans."https://t.co/T1NFucQdf7Public trust is essential before rolling out BA.5 boosters to millions of people

2022-08-18 00:46:53 The new study with longer follow-up of nearly 1.3 million people with Covid adds to the concerns and replication of these 2 brain imaging studies https://t.co/HJWtJWieWL

2022-08-17 22:56:08 Link for the editorial https://t.co/fnSZ6miI5AAnd quick summary @FT @clivecookson https://t.co/iNztfFpjjM https://t.co/BmVSUrWtBa

2022-08-17 22:35:09 Accompanying editorial @TheLancetPsych with good context @GlynLewis9 @drjprogers @ucl @UCLPsychiatry https://t.co/97NisoBsHq

2022-08-17 22:35:08 Main endpoint of increased risk and graphs showing timing over 2 years. Data from electronic health records, retrospective https://t.co/9bNlqJzUJo

2022-08-17 22:35:06 US data, lack of differences between variants (Alpha, Delta, Omicron) https://t.co/KmdPfaXj4h

2022-08-17 22:30:09 In 1.28 million people, up to 2 years after Covid, w/ matched controls: "The persisting increased risk of post-COVID cognitive deficit, dementia, psychotic disorders, and epilepsy or seizures" and "similar during the delta and omicron waves" #LongCovid https://t.co/FRyGDJ8pSd https://t.co/NuqJ5Fq0Kx

2022-08-17 21:13:10 Editorial: Stop using drugs that don't work.Ivermectin and Fluvoxamine and still widely prescribed.https://t.co/XfOPgSoyjE@ProfAbdoolKarim https://t.co/wEHoMpRVzv

2022-08-17 21:03:07 A randomized, placebo-controlled trial of 3 different drugs for Covid—metformin, ivermectin, or fluvoxamine—all of which failed to benefit with respect to primary endpoint, possible metformin benefit for a 2° endpointby @BramanteCarolyn and colleagueshttps://t.co/37zFMRvq8F https://t.co/ntmA0HBrvF

2022-08-17 19:59:22 Rapid waning of immune protection by BA.1/BA.2 infections (mostly breakthroughs) against BA.5 infectionshttps://t.co/9XTirVPDa2 15-day intervals (A->

2022-08-17 19:13:40 Give @CDCDirector for admitting "dramatic mistakes"https://t.co/zqvoJ1mkI1 the @FT coverage by @JamieSmythF with comments by @AmeshAAand me https://t.co/ESaAaWBbCP

2022-08-17 18:24:14 From yesterdayhttps://t.co/QNVmho3ikJ

2022-08-17 18:23:16 We went from sequence of #SARSCoV2 to highly effective vaccines in 10 months, which was unprecedented. But nearly 2 years later, we see no replication of such hyper-accelerated effort, despite remarkable advances in science Today @ScienceTM yet another https://t.co/aQCjw2Z30o https://t.co/BmbD7aDjWg

2022-08-17 17:21:31 How the amount of virus in infectees breathe changed as #SARSCoV2 evolvedhttps://t.co/dcNWs2Dtmchttps://t.co/opmUMvCgxd https://t.co/1UKBiPFNBx

2022-08-17 16:46:09 "The nightlife setting was the driver of Covid-19 spread, while household and healthcare settings were in the lower course of transmission chains"New report tracking Covid spread in Tokyohttps://t.co/kb9XFOGBKP https://t.co/HnxwVgcsbK

2022-08-17 16:13:29 @YouAreLobbyLud @CDCgov and now this.... https://t.co/rbW8X4RMlS

2022-08-17 15:49:16 We learned how to image cells without labelling, preempting disruption or killing, via deep learning #AI. Now the ability to sequence RNA of single cells without killing them https://t.co/cNyJcH987A another meaning to slice of life @BartDeplancke @EPFL_en @WanzeChen https://t.co/tX7Malx3EB

2022-08-17 02:56:18 Another step towards a pan-sarbecovirus, variant-proof vaccine. There are now >

2022-08-17 02:23:12 A brief #LongCovid thread well worth the read, on @jcouzin's @ScienceMagazine coverage/context of the new and insightful mechanistic report https://t.co/4bbg3VD5yV

2022-08-16 20:46:32 The denialist's Venn diagram https://t.co/5ih65iQwKo

2022-08-16 18:40:22 More perspective on the important new #LongCovid work by @sneakyvirus1 @VirusesImmunity @PutrinoLab and their colleagues @ScienceMagazine by @jcouzin https://t.co/vnVUVUpnIo“We should be trying these [potential treatments] right now” https://t.co/jhUL1OeHJf https://t.co/ZOj4RPqVkd

2022-08-16 17:25:33 Adding to the suboptimal T cell response in seniors, new data from @OHSUNews and @UTSWImmuno on how the neutralizing (and non-neutralizing) antibody response to vaccination diminishes with agehttps://t.co/rBEFjm5Qxd https://t.co/fxzKk1KHB3

2022-08-16 17:00:26 "Even a single case of paralytic polio represents a public health emergency in the United States."https://t.co/1Qavun6No3 new @CDCMMWR "95% vaccination coverage is required to provide herd immunity"https://t.co/pksC3nzU2E @FT @JamieSmythF @caitlinsgilbert https://t.co/d04pt3eEpk

2022-08-16 16:20:55 RT @YouAreLobbyLud: This is an excellent article by @EricTopol. It eviscerates the @CDCgov, and rightly so. I cannot understand what they a…

2022-08-16 15:05:13 The risk of blood clots in hospitalized patients with Covid vs influenza was increased 60-90% within 90 days, for venous but not arterial thrombosishttps://t.co/wPHf18NYYB @JAMA_currentRetrospective, much smaller influenza cohort from 2018-2019 https://t.co/sClYHF0J6U

2022-08-16 01:48:57 @ChristosArgyrop Thank you!

2022-08-16 00:48:16 New report on BA.2.75 today confirms less immune evasiveness compared with BA.5, and less cell-cell fusion than BA.5 https://t.co/u7hnNALX5a https://t.co/xgyPL5GRb7

2022-08-15 22:21:22 Bedside manner. From the patient perspective. Outstanding and inspiring, by Michelle Izmaylov @VUMChealth https://t.co/wnCrTpxh2B@AnnalsofIM https://t.co/MMgVx8OJbN

2022-08-15 22:02:48 RT @AnjKhem: "By steadfastly continuing to endorse this flawed CDC guidance, our public health agency has failed its namesake mission of co…

2022-08-15 18:16:56 Does multi-dose BCG vaccination help prevent Covid?A small randomized, placebo controlled trial in people with Type 1 diabetes https://t.co/iYUhzLnRyQ@CellRepMed https://t.co/fX0MXMvr1m

2022-08-15 17:15:42 RT @Kit_Yates_Maths: "The CDC position that we need to “live with Covid”, as espoused with its guidance, should be countered by exploiting…

2022-08-14 23:48:08 What I wrote about the @uk_biobank when it came out. The need for independent replication. That's what the new study provides.https://t.co/wySNMFcytY

2022-08-14 22:59:17 RT @Mike_Honey_: @EricTopol Thanks and I'm glad it was useful.Here's the full thread for more context - recent growth advantage is a heal…

2022-08-14 19:42:11 The formidable challenge of BA.5 doesn't detract from the outstanding containment of the virus and high adoption of vaccines in these countries, with a 6-11 fold reduction of cumulative mortality per capita compared with the United States@OurWorldInData https://t.co/00wQpIlJ3T

2022-08-14 19:00:11 For the multitude of people who think mild cases of Covid are totally meaningless, these results would beg to differ. Yes, it's a short-term effect so far and may be partially reversed over time. Yes, likely to be less w/ current variants and vaccination. But denial doesn't work.

2022-08-14 18:30:40 This week a new post-Covid brain MRI study was published, without baseline images and not as large as the best study to date by @uk_biobank I've compared them herehttps://t.co/SIWJuCDidR @PNASNews https://t.co/JF5UviTdYO @nature https://t.co/5zXZ0csnLV

2022-08-14 17:29:35 The rise of BA.2.75 has been studied very carefully by @TWenseleers and its trajectory may vary considerably between countries. Or we could see a co-dominance pattern, something that hasn't occurred yet /9 https://t.co/myYGLCDDGg

2022-08-14 17:29:33 More on BA.2.75Unlike BA.4.6, more evasive to BA.5 breakthrough infectionsGrowth advantage tied to enhanced ACE2 bindingBebtelovimab and Evusheld predicted to still be effective No sig increase in hospitalizations in India /8https://t.co/T8iIzUGTvZhttps://t.co/B7RGir61Hc

2022-08-14 17:29:32 What about BA.2.75?Spike: 9 amino acid residues differ from BA.2One report of less immune evasion than BA.5https://t.co/aSNpEAdW5KSimilar pathogenicity as BA.5 in expt'l model /7https://t.co/bFG1mrwYHi https://t.co/4ggttrP8cK

2022-08-14 17:29:31 What do we know about BA.4.6's properties?https://t.co/E4QrGwV6BZSpike mutation R346T may be keyIt appears to have more immune evasion than BA.5, some cross-immunity w/ BA.5 breakthrough infections, not resistant to Bebtelovimab, but Evusheld may not protect as well /6

2022-08-14 17:29:30 And to avoid spike-centric thinking, the mutation differences extend well beyond the spike, such as in the nucleocapsid (N), envelope (E), or ORF7b /5 https://t.co/Ma6PsxIFf8

2022-08-14 17:29:29 There are substantial differences in mutations for these 2 variants, spike map here, with context /4https://t.co/ExWF5Dsbhw https://t.co/7JERUyUkl6

2022-08-14 17:29:28 In the US, BA.4.6 has a foothold accounting for 5% of new cases https://t.co/jjl2AnwOWX, newly updated.BA.4.6 has been steadily growing here since JuneIt is already at 13% in US Region 7 /3 https://t.co/s5UndyXda2

2022-08-14 17:29:26 While BA.2.75 is becoming dominant in India, out-competing BA.5, we're now seeing signs it can also compete with BA.4.6 in Australia, as posted by @Mike_Honey_ /2 https://t.co/r1sRc2YjJm

2022-08-14 17:29:25 What variant will take over for BA.5 in the United States and why does it matter?It's currently between a BA.4/5 vs BA.2 subvariant https://t.co/V1UsNSU6m7

2022-08-14 16:49:04 @RenzPolster Yes, I made that point https://t.co/IEMD9R3LtU

2022-08-14 16:05:31 The @uscensusbureau data for #LongCovidSelf-reported, without controls, or pre-Covid baseline symptoms like the new Netherlands study (12% prevalence) https://t.co/nnZsWWa0jVBut, no matter how you look at it, it's affecting a substantial number of people https://t.co/10abaYrpJR

2022-08-14 14:20:10 RT @CrabbBrendan: Thanks again for this excellent summary @EricTopol. And while we search for 'cures', I can't stress enough your final con…

2022-08-13 16:25:04 @paulg The protective power of massive prior infection exposure (hitting majority of their populations) which also adds to vaccine protection with hybrid immunity (vs the whole virus plus enhanced vs spike).Explained in full herehttps://t.co/pQYFuqy954

2022-08-13 16:20:36 Previously it was @GeisingerHealth and @Regeneron. Now it's @MountSinaiNYC and @Regeneron. Large health systems with their electronic health data and genomic sequencing for potential of drug discovery, but also bioethical considerationshttps://t.co/0rScAFfaYc by @JoeKGoldstein https://t.co/wLkD7A9yie

2022-08-13 15:28:39 @calirunnerdoc Yes, evidence from multiple reportshttps://t.co/tatxeNskY9

2022-08-13 15:18:39 Many other countries, like the US, had major case surges uncoupled from deaths as a function of their immunity walls, particularly related to prior infections. Discussed here https://t.co/pQYFuqy954

2022-08-13 15:18:38 The BA.5 wave resulted in higher deaths than from any prior variant in Australia, New Zealand and soon to be the case in Japan. That's despite very high vaccination and booster rates, attributable to BA.5's extreme biologic properties of immune escape and transmissibility https://t.co/z9TxC6shTR

2022-08-13 15:01:50 In one week's time we learned more about #LongCovid that we had in months, including evidence for a potential biomarker. Yet we're still way behind where we need to be to help millions of people who are affected. https://t.co/IEMD9R3LtU https://t.co/ONWeuShJ1o

2022-08-13 14:25:58 Thread referred to by @holmescnn https://t.co/dKNsWXpM0b

2022-08-13 14:25:57 Last evening, we discussed the new @CDCgov guidelines, purportedly a shift to "protect the vulnerable," but fail to do so on many counts https://t.co/lJeFXASFjs

2022-08-12 17:34:36 RT @Karl_Lauterbach: Hier noch einmal eine gute Übersicht der Studien, die ab 50 einen klaren Überlebensvorteil der 4. Impfung zeigen. Die…

2022-08-12 16:58:36 RT @profhelenward: Excellent summary of evidence from recent Long Covid studies. Suggests clusters, and possible mechanisms for some.Also…

2022-08-12 15:57:50 @manda_trkac @ImmunityCP @kieluni Agree! Not petty at all.

2022-08-12 15:47:43 @ImmunityCP On T cell response to vaccination in seniors"Our results reveal that an intrinsic defect of the CD4+ T cell repertoire causes the age-dependent decline of immune response quality against SARS-CoV-2"https://t.co/ensXlddJ3T @kieluni https://t.co/VnCZf2RkTn

2022-08-12 15:38:56 For context"The increase in maternal death during delivery hospitalization and pregnancy-related complications during the pandemic is alarming."@JAMANetworkOpen todayhttps://t.co/TOvbaiWeSB by @Rose_L_Molina @BIDMC_ObGyn @HarvardChanSPH @joefigs2 @harvardmed https://t.co/zpCCNfdTwR

2022-08-12 14:42:20 RT @pranavrajpurkar: Delighted to share our review on "Self-supervised learning in medicine and healthcare" in Nature Biomedical Engineerin…

2022-08-12 13:34:58 The US booster botch for even 3rd shots. All @OECD countries except US >

2022-08-12 13:34:57 Summary of data supporting survival benefit of a 4th shothttps://t.co/lMLDEgpQvL

2022-08-12 12:54:05 RT @sheencr: Really excellent summary from ⁦@EricTopol⁩ on #LongCovid latest data incl markers to identify patients (a role for cortisol) a…

2022-08-12 04:34:31 RT @uche_blackstock: The CDC is relaxing COVID guidelines and saying it’s because we have a high percentage of population immunity when onl…

2022-08-12 01:06:10 In the past week, there's been a flurry of new, informative reports on #LongCovid. I've tried to summarize them here along with the implicationshttps://t.co/IEMD9R3LtU (PS you can subscribe, it's free)

2022-08-12 00:11:21 This seems importantClassified documents relating to nuclear weapons were among the items FBI agents sought in a search of former president Donald Trump’s Florida residence ohttps://t.co/tclYL3Nbyh

2022-08-11 23:06:01 Marked reassurance for safety of Covid vaccines and reduction of significant health events in pregnancy with an unvaccinated pregnant control grouphttps://t.co/rHhkzKO1BA @TheLancetInfDis https://t.co/jEOyjRvUlq https://t.co/ZqBnREl5sa

2022-08-11 20:06:25 RT @EricTopol: Covid and the brainhttps://t.co/SIWJuCDidRJust published @PNASNews —cortical atrophy and cognitive dysfunction in 81 peop…

2022-08-11 19:40:09 Covid and the brainhttps://t.co/SIWJuCDidRJust published @PNASNews —cortical atrophy and cognitive dysfunction in 81 people with mild Covid vs matched controls (as seen in @uk_biobank study)—astrocyte infection in severe Covid, recapitulated by iPSCs https://t.co/p8Id5nzbO3

2022-08-11 19:26:49 Our CDC at work. This is embarrassing, to say the least. https://t.co/21IFipxDNl

2022-08-11 19:17:30 The 4th shot in Americans age 50+ 10% age 50-6425% age 65+The US now ranks 80th in the world for booster vaccines at 32% of populationhttps://t.co/gWCbSb6EfD https://t.co/SOtBwq1zCZ

2022-08-11 19:13:21 My concerns a month ago, unaddressedhttps://t.co/AzO91kFuMQ

2022-08-11 19:06:14 https://t.co/RrJM060RXw is the link

2022-08-11 19:06:13 The @CDCgov doubles down on its flawed, not evidence based Covid recommendations with a new guidance document1. Leaves fully vaccinated = 2 shots, stay "up to date"2. Leaves isolation at 5 days w/o rapid tests3. Pushes "community levels" when real info is "transmission levels" https://t.co/Sflm8U0xbS

2022-08-11 17:13:50 The positivity rate of self rapid antigen tests tracked well with PCR throughout the United States Omicron and subvariant waves https://t.co/zNZYmyHZf6 https://t.co/cOzT3bbDpc

2022-08-11 17:04:35 CAPTCHA 2.0 :-)by @speedbumpcomic https://t.co/2DYo2YIG3g

2022-08-11 16:31:59 We've learned a lot this year about the underpinning of Epstein Barr virus in multiple sclerosis. The gut #microbiome is also important, as delineated in this excellent review https://t.co/11ly64ojsR @NatRevNeurol https://t.co/OLae2MFyeJ

2022-08-11 16:10:51 Persistent circulating spike protein in #LongCovid (PASC)https://t.co/R7QmEFaeMSAdds to finding of antibodies to #SARSCoV2 nucleocapsid (N) in unvaccinated people with Long Covidhttps://t.co/jFbxvhdOWP https://t.co/OZdrDPEb3y

2022-08-11 15:06:38 Until now, most #AI in medicine has involved large annotated datasets for inputs, known as supervised deep learning. Next up is self-supervised learning. @RayanKrishnan @pranavrajpurkar and I review this topic @natBME https://t.co/5Uyrc8rX4m https://t.co/81EhU0StVi

2022-08-11 02:00:53 There have now been >

2022-08-11 00:58:25 @_TheAncientOne_ @ewencallaway @Nature @yunlong_cao Yes, it would be good to hear from Yunlong on this contradiction

2022-08-11 00:37:18 What about BA.2.75?“I think people who have had BA.5 will not have a breakthrough infections with BA.2.75, and vice versa.”https://t.co/T8iIzUpi7p by @ewencallaway @nature w/ @yunlong_caoand https://t.co/2dFHUOIv2T https://t.co/iqwpQvneFk

2022-08-10 23:53:08 BA.4.6 is currently the only other variant in the US besides BA.5 that has appreciable growth, at ~5% of cases, w/ its R346T mutation. A new study suggests:—Cross-immunity w/ BA.5 breakthrough infections—Bebtelovimab still potent, but Evusheld escapehttps://t.co/E4QrGwV6BZ https://t.co/nJ2SofgG5b

2022-08-10 19:25:26 The low cortisol levels and ACTH in the #LongCovid group is especially intriguing, supports a dysfunctional hypothalamic-pituitary-adrenal axis, not so simple for steroid Rx. May help explain some symptoms and serve as a potential biomarker https://t.co/tT1wPBKZ9q

2022-08-10 18:18:10 My colleagues @scrippsresearch just published exciting work discovering broad neutralizing antibodies from macaques (with their structural biology) that could be used as a template for variant-proof Covid vaccineshttps://t.co/lbTuGRzWvh @andrabi_raiees @DennisRBurton @menz45 https://t.co/2rDWrAiYQ5

2022-08-10 17:30:57 Correction, typo: its striking BA.2 wave

2022-08-10 17:26:43 South Korea's BA.5 wave. Currently highest cases per capita in the world. Much less impact than (and an outgrowth from) its striking BA.1 wave.@OurWorldInData https://t.co/ui1mrfJr4c

2022-08-10 16:56:14 An extraordinary high-resolution map of the heart after myocardial infarction, with spatially integrated single-cell gene expression and epigenomics https://t.co/P1L6bTDUdI@Nature @rkramann @KuppeChristoph @saezlab https://t.co/b9WIJtihd8

2022-08-10 15:46:32 And here's the explainerby @VirusesImmunity https://t.co/9TMcyKrGXV

2022-08-10 15:42:45 New insights on the underpinnings and biomarkers for #LongCovid (LC) in a systematic study https://t.co/jFbxvhdOWP*Uniformly low cortisol level*, along w/antibody and T cell findings @VirusesImmunity @PutrinoLab HC-healthy controls, CC-convalesced w/o LC https://t.co/3IN7RckkdE

2022-08-10 15:11:41 @K_G_Andersen @NatRevImmunol @rahulsurya85 @TheOttLab Yes, I see your point for how the table is over-simplified and can be misleading. Their point on susceptibility to *infection* as a function of variant (not severe disease, yet not specified in the text) has some merit, consistent with what is being seen clinically

2022-08-10 14:59:00 How does Covid heighten the risk of clotting?https://t.co/WT96lC9dyB@NatRevImmunol @emconway99 @JHMorrissey https://t.co/DkXwSpUbRB

2022-08-10 14:45:55 If you thought we've seen the end of major #SARSCoV2 variants, think again https://t.co/DkiguWbGJ9

2022-08-10 14:29:54 The enhanced protection afforded by hybrid immunity (Covid infection plus vaccination) is influenced by variants https://t.co/ocjVAUDpZF @NatRevImmunol @rahulsurya85 @TheOttLab https://t.co/X7d4L6wAS8

2022-08-10 00:57:34 End of paper:"Consistent w/ this perspective, 70 investigators signed a letter to the FDA on April 21, 2022 encouraging the inclusion of T cell responses in addition to antibody titers for the evaluation of SARS-CoV-2 vaccines in humans"Letter (I signed)https://t.co/cvgOcvas96 https://t.co/r1vB5joQjE

2022-08-10 00:51:36 And what happens if you deplete CD8+ (cytotoxic) T cells with a monoclonal antibody after vaccination + #SARSCoV2 infection?https://t.co/7wjpI8rILe @SciImmunology (macaque model) https://t.co/glworgmhVU

2022-08-09 22:22:37 Why are people age 50+ at higher risk of severe Covid?A new @PNASNews study indicates their significant narrowing of T cell diversity in response to infections may be part of the explanationhttps://t.co/vamn6sp8ug https://t.co/kbtIfnMv0Y

2022-08-09 20:46:51 @calirunnerdoc @Nature @heidiledford I agree with this concern. Most, if not all, of the trials are small

2022-08-09 19:55:13 Important to emphasize this is a potential that has not been actualized clinically.But all the more reason to be prepared, accelerate efforts to have backup and combination oral anti-virals

2022-08-09 19:51:31 @JuliaRaifman For current virus, likely yesFor Mpro resistant mutations (*if* they become prevalent), hard to know

2022-08-09 19:35:40 More signs that Paxlovid resistance may be on the horizonhttps://t.co/ARkSE5akdRhttps://t.co/2BFZ9NWS1t https://t.co/nNDetN8bot

2022-08-09 19:08:08 @nlj @OurWorldInData No question! US has >

2022-08-09 17:53:48 Recognition for the 1st open-source Covid vaccine phenomenal contribution by @mebottazzi and @PeterHotez @FastCompany by @adambluestein https://t.co/V21apBgAvf https://t.co/n6AujxMikQ

2022-07-26 23:53:38 RT @EricTopol: A new BA.5 variant report from Portugal indicates higher rate of hospitalization (>

2022-07-26 19:47:48 BA.5 in AustraliaNew record of hospitalizations @covidbaseau Sharp rise in deaths @OurWorldInData https://t.co/PQYcZtmSOl

2022-07-26 18:58:08 RT @bhrenton: As today's White House summit starts in the next hour, a pertinent commentary by @EricTopol and @VirusesImmunity, who propose…

2022-07-26 17:32:30 The length of time of infectiousness of #SARSCoV2 https://t.co/IB2yW3wMjT"There is no data to support 5 days or anything shorter than ten days [of isolation]."Paxlovid rebound may extend that further

2022-07-26 16:11:16 The BA.5 variant now accounts for 82% of new cases in the United Stateshttps://t.co/jjl2AnwOWX https://t.co/8M1MtXtXyu

2022-07-26 15:57:11 "Hundreds of thousands of [Evusheld] doses sit on shelves in hospitals and infusion centers across the country" while the vast majority of 7 million immunocompromised Americans who would benefit are not getting this prevention https://t.co/LhL4WofyFF

2022-07-26 15:07:31 New @ScienceMagazine on the science of the origin of #SARSCoV2 https://t.co/FH7eNfRfHshttps://t.co/YLTRcFx7fX https://t.co/2y8krUeoY0

2022-07-26 14:51:40 But despite this and demonstrated efficacy &

2022-07-26 14:51:39 Just out @ScienceTM The robust antibody immune response that an mRNA vaccine induces in children, including "highly preserved omicron-specific functional immunity"https://t.co/Qsa0fxdhwv @ragoninstitute https://t.co/n5iExIZlla

2022-07-26 14:30:00 The body of evidence for the protective benefit of masks, updated with multiple new studies, for community and health care settingshttps://t.co/1hsoxKYaNX @AnnalsofIM https://t.co/m6QWBWVbrp

2022-07-26 14:02:01 @backagainmaybe @mehdirhasan the graph was for Japan, and deaths are on the rise there https://t.co/Fa2nKoDykY

2022-07-26 13:48:42 The absolute rates of hospitalization are low, due to the immunity walls built in Portugal and Denmark (from vaccines, boosters, infections), but the increase with BA.5 reflects its higher virulence/pathogenicity

2022-07-26 13:19:39 No sign of BA.5 wave let up here https://t.co/3qdpIeF2Je

2022-07-26 05:14:01 A new BA.5 variant report from Portugal indicates higher rate of hospitalization (>

2022-07-26 02:56:45 No. https://t.co/l3bE5AIgNM @CellRepMed https://t.co/PPkROpI2ON

2022-07-26 00:44:26 RT @EdwardTufte: Brilliant and credible reporting of current situation. To reason about a pandemic requires pandemic data, a longer time…

2022-07-25 22:19:25 Here's the agenda for tomorrow's WH meeting on future of Covid vaccines. You can register here: https://t.co/1o8JKN1FdW I was asked to join the 2nd panel, but unable to make it. Great that @VirusesImmunity will be there. Let's gets nasal &

2022-07-25 21:15:11 if you don't have time to read the above @statnews piece, here's the gist https://t.co/kWrYthpweS

2022-07-25 21:11:17 https://t.co/tk7xwvLO8Phttps://t.co/tk7xwvLO8P

2022-07-22 15:19:04 Some reassuring new data for #LongCovid in kidshttps://t.co/6M7eDe0CaP Only "slightly higher" than the rates vs matched children without Covid, more seen in hospitalized and older kids @JAMANetworkOpen https://t.co/zZYQCjXHME

2022-07-22 14:26:26 Very good to see that the rare and potentially fatal Covid MIS-C in children (multi-system inflammatory syndrome) has markedly declined with Omicron, 95% less than Alpha https://t.co/6TcTFwBybn @deniseroland https://t.co/J9nSV55UGV

2022-07-22 14:16:24 Where the spread of the BA.5 variant has outpaced the prior BA.1 wave with nearly 200,000 cases yesterday https://t.co/bSW4QCF9Gp

2022-07-22 14:00:39 RT @ddiamond: White House has vowed to go “above and beyond” CDC guidance to care for Biden.“The fact they are overriding CDC recommendat…

2022-07-22 13:53:07 The prognosis is good, may take longer to fully resolve with BA.5. I also spoke to Kim about debunking the notion that vaccines "are not working." Yes, they're leaking re: infections, but they've already saved >

2022-07-22 13:06:05 RT @IforRWilliams: A clarion call from @EricTopol @VirusesImmunity in a new editorial:"As the virus continues its accelerated ability to e…

2022-07-22 04:39:10 @ShanLuLiu1 @SciImmunology @VirusesImmunity Such an important study and contribution from you and your colleagues. Back to you—thanks!

2022-07-22 02:51:18 RT @VirusesImmunity: I am thrilled to coauthor an editorial piece for @SciImmunology with @EricTopol highlighting the need for Operation Na…

2022-07-21 22:22:53 @TWenseleers After a few weeks looking at 2.75, your post was the first one I saw for any place outside India w/ growth advantage over BA.5 (despite detection in so many countries). There are mixed data out on its immune evasion. Agree it needs to be watched

2022-07-21 21:37:45 Here's the list of the 12 nasal vaccines in clinical trialshttps://t.co/xbbjwc4Ln7 @TheScientistLLC https://t.co/LJzN3S3vyT

2022-07-21 21:27:35 @TWenseleers Appreciate your points, Tom, w/ BA.2.75 data from countries w/ a BA.5 bkgd. My point on "scariants" (a word I coined) is that we needn't get carried away until we have clearcut + data, since so many have turned out to be false alarmsOthers feel similarlyhttps://t.co/yZgM8Bfk9Y

2022-07-21 20:02:47 RT @SciImmunology: “The prospect of achieving [containment of #SARSCoV2] with nasal vaccines is high, but will only be possible with dedica…

2022-07-21 19:03:53 We fully recognize the challenge of a successful nasal vaccine for high efficacy &

2022-07-21 18:57:42 That's "lightning speed" not lightened.There are now 12 nasal vaccines in clinical trials and 4 are far along, in Phase 3.But no plans for manufacturing at scale, distribution, accelerating. No government support. Yet a major unmet need

2022-07-21 18:27:50 It accompanies an elegant study in people &

2022-07-21 18:27:49 In today's @SciImmunology, @VirusesImmunity and I call for Operation Nasal Vaccine, the urgent need for a lightened speed initiative, to help block Covid infections and transmissionhttps://t.co/OujfFxMgU6 https://t.co/a6bXX7sy01

2022-07-21 17:09:36 But the 65% increased risk of hospitalization for BA.5 is a source for significant concern, if replicated would point to higher pathogenicity and virulence for this variant

2022-07-21 17:01:39 "No evidence of decreased vaccine effectiveness against BA.5 compared to BA.2" (With most extensive genome sequencing to date to help differentiate variant effects)

2022-07-18 14:59:10 BA.5 in Greece https://t.co/5Rrdcwfdbx

2022-07-18 14:07:26 Novavax vaccine with booster induced neutralization antibodies vs BA.1 and BA.4/5 as well as 3 mRNA shotshttps://t.co/p3Pkeh30UT https://t.co/uYQp9fyOpu

2022-07-18 13:54:27 Not "Living with Covid" by the @bmj_latest Editorshttps://t.co/PettYwCGzk"How is the government responding to this crisis? Largely by pretending it is not happening or implying it is all under control."Seems familiar here https://t.co/89PKIs6UWw

2022-07-18 13:46:41 @matthewherper Thanks Matt. It was always a fishy story, too good to be true

2022-07-18 13:31:32 Our covid times :-)by PC Vey @NewYorker https://t.co/bgWZQUBxkn

2022-07-18 00:15:36 Epstein-Barr virus is the leading cause of multiple sclerosishttps://t.co/Q7aEwL45ZwSummary of one of the most important advances in life science this year @ScienceMagazine https://t.co/2tUgZrfxye https://t.co/8FjgOstXsu

2022-07-17 21:37:21 "But last week we got a reminder of other kinds of facts, the kind that bring us awe and comfort and context — even joy. The kinds of facts that prompt scientists to break down in tears."https://t.co/LYg2cwKQXh+ @sdutBreen :-) https://t.co/nl6N0BA9Ln

2022-07-17 19:28:23 @uhoelzle Yes, I do think more infections in the unvaccinated reference group is playing a role, reducing the VE gradient. But they're also frequent in vaccinated, which should bolster immunity. Paxlovid is now heavily being used, adding another confounding factor for hospital admits

2022-07-17 19:18:55 OTOH, hospital admissions are up more sharply in many countries that provide their data, overall well below BA.1 levels, for the same reason https://t.co/BNfkHN95PU

2022-07-17 18:57:29 The world and the BA.5 wave—2nd highest in confirmed cases after Omicron BA.1 with substantially less reported—Uptick in deaths, fortunately much lower than BA.1, due to population immunity wall of vaccines, boosters and infections@OurWorldInData https://t.co/2i8uYgRcjU

2022-07-17 15:14:46 Boosters are essential to provide protection, but that may be slipping as the virus continues to evolve.Not encouraging.From >

2022-07-17 01:16:22 RT @debra_caplan: After successfully avoiding Covid for 2.5 years, my husband tested positive for Covid 3 weeks ago, cleared the infection,…

2022-07-16 21:17:55 @UrnovFyodor Thanks. Hope for a rapid and full recovery, Fyodor

2022-07-16 20:45:06 And herehttps://t.co/wpFmCmul30

2022-07-16 20:15:49 @anonymous1967x Agree!

2022-07-16 20:07:59 So many candidates, yet so little attention https://t.co/xbbjwc4Ln7 @TheScientistLLC by @JefAkst https://t.co/7bWAKxrlHl

2022-07-16 19:54:42 I recently wrote more about this and what can be donehttps://t.co/vwK1ZXsU7mhttps://t.co/ibgdJ7yYlI https://t.co/eXLGIFtyUT

2022-07-16 19:50:46 @SmoMichelle @StudBigg That's why I tried to simplify itHere is the Figure and the legend, p. 34And I previously wrote at length about this topichttps://t.co/vwK1ZXsU7m https://t.co/Ak879dwgoE

2022-07-16 19:40:24 @StudBigg there's a link if you are not too lazy to look at it and answer your question

2022-07-16 19:31:25 As the variant antigens drift further away from the ancestral #SARSCoV2, with more immune escape, growth advantage and fitness of the virus, the people drift off to sleep rather than taking initiativeAntigenic map adapted from https://t.co/VBDwVFH3Su https://t.co/0zo0AE8zwl

2022-07-15 23:26:28 Do the added mutations in BA.2.75 confer a different immune evasive pattern cf BA.5?Yes, at least that appears to be the case for Bebtelovimab, which has still shown efficacy for BA.5Other differences noted.https://t.co/Wf6uHNbGIW Mutation map at right by @PeacockFlu https://t.co/BTdGuT1B3v

2022-07-15 19:54:45 Acknowledging that the unvaccinated reference group is much more apt over time to include people w/ Covid infections. But so are the vaccinated, w/ hybrid immunity. IMO, there are multiple signs of VE attrition in this data set, particularly for BA.2 variants. No BA.5 data yet

2022-07-15 18:12:02 Recall that through the Delta variant w/ a 3rd shot booster, vaccine effectiveness vs hospitalizations was maintained ~95%

2022-07-15 17:46:40 This is quite telling about the slippage of protection of vaccines vs hospitalizations. With BA.2/BA.2.12.1 and 3 shots, in age 50+, vaccine effectiveness was only 55%.Restored to 80% w/ 4th shot Too much happy talk about vaccines providing great protection from severe disease https://t.co/5wOtxQU9Zf

2022-07-15 17:42:58 New CDC @CDCMMWR on Omicron variants (BA.1, BA.2, BA.2.12.1) Importance of booster to restore vaccine effectiveness improved after significant drop-off (Table), BA.2/BA.2.12.1 variants worse declineBenefit3rd shot all ages 18+4th shot age 50+https://t.co/nlB0B7A9R1 https://t.co/LDP1Lus6Uz

2022-07-15 16:55:10 New: 2nd booster/4th shot broadening in the UK"people aged above 50, along w/ residents &

2022-07-15 16:36:59 RT @PeterHotez: At the risk of sounding like a broken record: maximize your boosters. Get your 2nd booster (4th immunization) if you are el…

2022-07-15 14:34:45 Misleading: Detection ≠ Spreadhttps://t.co/ryd3Wyv6IK https://t.co/ywXKA2ylep

2022-07-15 14:28:04 US Covid hospitalizations crossed 40,000 for first time since the end of February and slope of their ascent is increasinghttps://t.co/QPRo6jaOka https://t.co/oYIST9PYeL

2022-07-15 14:19:54 RT @EricTopol: Yet another study of improved survival with 4th dose of vaccine compared with 3rd, nationwide Sweden, here for age 80+https…

2022-07-15 02:03:28 With #COVIDisAirborne, the factors that modulate the duration of aerosol infectivityhttps://t.co/Bc9Iwx4uV0 @PNASNews @JakobLondahleditorial to https://t.co/DLhZvenOvj https://t.co/s5DdBWTZhL

2022-07-14 23:44:14 Reduction of death for age 50+, 4th vs 3rdhttps://t.co/HGyjNwCm0v https://t.co/dntiKA57IH

2022-07-14 23:44:12 Here for improved survival, 4th vs 3rd shot, age 60+https://t.co/tcGQ0D9aM9 https://t.co/SYLM0XjqK1

2022-07-14 23:21:35 Yet another study of improved survival with 4th dose of vaccine compared with 3rd, nationwide Sweden, here for age 80+https://t.co/tWMhxQdYxn https://t.co/jSKBxtK7Hi

2022-07-14 21:12:31 Nice summary of this report @Nature https://t.co/5kiusZ6XB5 by @meprillaman w/ @profshanecrotty https://t.co/OxlHpp5kTJ

2022-07-14 19:13:57 Very good explainer on imprinting @FT to complement the new publicationhttps://t.co/5MmqWrLmFC

2022-07-14 19:13:56 The #SARSCoV2 infection imprinting problemhttps://t.co/PE4QjMv69Unew @ScienceMagazine by @BoytonRosemary @Daltmann10 @imperialcollege and colleagues https://t.co/fZYaTcWYv2

2022-07-14 17:37:04 @saahilmenghani Hard to give strong recommendations without specific immunologic data but, in general, mixing (not matching) an adenovirus-vector or whole virus with an mRNA or protein--primary series/booster or vice versa--would be expected to induce broadest immune response

2022-07-14 17:14:52 @ScottGottliebMD Important qualifier. Thanks for noting

2022-07-14 17:11:46 Reassuring.There are no signs of spread of BA.2.75 ("Centaurus") in any other country besides India, a place with minimal BA.5 https://t.co/bQuxSTGGa9

2022-07-14 01:27:03 Full @pbsnewshour segment on the BA.5 variant, Paxlovid, action steps, with transcripthttps://t.co/grWLMlK8lK w/ @WmBrangham and @JudyWoodruff

2022-07-14 01:05:22 Latest review of incidence and natural history of myocarditis/pericarditis following Covid vaccination with 46 studies, >

2022-07-13 23:26:01 RT @NewsHour: The new BA.5 coronavirus variant is fueling yet another wave of COVID-19 infections. The CDC said it's now the dominant strai…

2022-07-13 22:11:52 Good https://t.co/zimKAarr8Z

2022-07-13 22:01:16 Ladder diagram of variant growth advantage, shown at yesterday's @WHCOVIDResponse BA.5 press briefing https://t.co/W2pfbrI3ys by Tony Fauci https://t.co/e0TVBnbPJF

2022-07-13 21:52:30 RT @AliHMokdad: Agree with @EricTopol “They haven’t gotten across that two shots is totally inadequate,” they are not doing enough and not…

2022-07-13 21:10:00 2 @NEJM reports on acute hepatitis in children raising the question as to whether adenovirus 41 is involved—still not resolvedhttps://t.co/Lwq8gjPEd7https://t.co/BOdLOaUVQB https://t.co/KJNeSmbdo0

2022-07-13 19:21:34 US Covid status: difficult to track, but this is what we've got:Hospitalizations about to cross 40,000 todayhttps://t.co/QPRo6jaOkaAll metrics are uphttps://t.co/OYKQV2K7hr https://t.co/uVwcvMkZZQ

2022-07-13 18:29:00 A step towards a universal flu vaccine https://t.co/Dgb7cPg6YP @ScienceTM A more formidable challenge than one (variant-proof) to #SARSCoV2 as we reviewed @nature here https://t.co/eKHGg7EPtM https://t.co/ZNtft5C9M3

2022-07-13 16:03:48 How #SARSCoV2 infects/affects brain astrocyteshttps://t.co/bXKLN6GzCg @PNASNews by @Andrews_MG @tmturkee @TheOttolab @Kriegsteinlab and colleagues https://t.co/Tlk4PNMHp6

2022-07-13 15:16:59 @NateSilver538 @OurWorldInData New Zealand is a model country for how it managed the pandemic, including a high vaccination &

2022-07-13 15:03:52 @NateSilver538 @OurWorldInData Yes, that hasn't changed throughout the pandemic. The signal from small population countries can be difficult to interpret, but longitudinal assessment helps. As does global contexthttps://t.co/dDpgqd3vpf https://t.co/XOMiVDzCBO

2022-07-13 14:55:53 BA.5 in New ZealandNote deaths vs Omicron BA.1 wave@OurWorldInData https://t.co/MilkXb3MtD

2022-07-13 01:42:51 This is better than what might have been predicted with the relatively narrow observed immune response from BA.1., BA.2. Bodes well for some added protection vs BA.5 from a BA.1 booster

2022-07-13 01:39:59 @kallmemeg Yes, certainly, Meaghan. it's the known "boost (bird) in the arm (hand)" benefit now vs. some unknowns in the months ahead. No right answer, but the way BA.5 is erupting here would think to. take the up-front protective benefit for those at increased risk

2022-07-13 01:01:57 New study from Qatar on BA.4/5 reinfection—Protection of a previous infection against BA.4/BA.5 was lower than that against BA.1/BA.2 (>

2022-07-13 00:47:20 @ejwillingham and also seen with Delta, as they demonstrated. Thanks

2022-07-12 23:48:26 Another undesirable feature of the BA.5 variant: Enhanced antagonism of innate immunity not seen in prior Omicron variants (BA.1, BA.2) https://t.co/6AfXx0RuBO https://t.co/nQ9e9vs6fa

2022-07-12 22:15:23 Thinking about the overlap of Americans who are still Covid cautious and those paying close attention to the Jan 6th hearings...... and those ignoring both

2022-07-12 21:11:49 https://t.co/WPD4HOwHTo

2022-07-12 21:11:48 The US pandemic mortality gap vs Canadahttps://t.co/mkc4PuljI3 by @DFisman @PNASNews "How many lives could have been spared, had it emulated some of its global peers"Editorial accompanying paper by @Alison_Galvani and colleagues in connected post below https://t.co/OFIIN06A96

2022-07-12 18:37:08 For now https://t.co/Uomri7gwwX

2022-07-12 17:40:00 @Ddrekonja Agree on that. Thanks

2022-07-12 16:55:36 Would add hybrid immunity to the boost later column (i.e. 3 shots and a prior infection). Note this refers to a 4th shot, with a person beyond 4-6 months from 1st booster

2022-07-12 16:52:14 I'm getting a lot of "To boost or not to boost" questions, so here's a Table with some recommendations now that boosters will soon be available to all adults. There are many uncertainties for waiting, and the original vaccine boost provides an extra layer of protection. https://t.co/FWq0m8p4g4

2022-07-12 16:16:10 BA.5 is now >

2022-07-12 15:40:20 @NightShiftMD Many thanks, Brian

2022-07-12 15:33:07 What happens if we don't take much more aggressive steps now towards nasal spray and variant-proof vaccines when an even worse #SARSCoV2 immune evasive variant shows up in the months ahead?

2022-07-12 15:21:12 Just published @ScienceMagazine are 2 more broad neutralizing antibodies with "unprecedented breadth" that add to a long list of well-suited candidates/basis for a universal pan-β-coronavirus vaccine https://t.co/VP75TyBMN7https://t.co/ZFT0pmYZXN https://t.co/VzCk5aELhY

2022-07-12 14:47:20 Today @CDCgov finally warned about BA.5Can you please fix the other issues on this punch list? https://t.co/AzO91kFuMQ

2022-07-12 14:35:39 @Laurie_Garrett @uche_blackstock @WhiteHouse Finally, the wake-up call ⏰

2022-07-12 14:17:31 @CarlosdelRio7 @latimes Thanks Carlos

2022-07-12 13:54:29 @CarlosdelRio7 @CDCgov The CDC is a major reason why this occurredA year after boosters were validated to save lives, the CDC still says "fully vaccinated"= 2 shotsAnd https://t.co/Amgvw8BEGw

2022-07-11 17:49:08 People keep writing "it's just a cold now." Wrong. https://t.co/HwRh6GlKd7

2022-07-11 17:49:07 You can't will it away.The rise of BA.5 globally https://t.co/xN9tUBUlla

2022-07-11 17:44:20 Good (new) summary of the @UK_biobank brain study. A larger cohort with paired imaging and matched controls from this exceptional resource is expected later this yearhttps://t.co/91yvemya8L https://t.co/uLBchEop8E

2022-07-11 16:15:59 BA.5 has evolved substantially from its Omicron predecessor variants, now acquiring enhanced cell infectivity like Delta, beyond its formidable immune escape. What are the implications? https://t.co/ibgdJ7yYlI https://t.co/hcw2rZapOH

2022-07-11 15:37:28 @DeepaRamani1 @rosemaryCNN I did thathttps://t.co/ibgdJ7yYlI

2022-07-11 14:53:45 @WHCOS @WHCOVIDResponse @ScottGottliebMD Yes it's critical. So why isn't it being shouted from the rooftops? "You should consider" is a different message than there is a body of evidence to show it's lifesaving.https://t.co/YzhFOuKPDmhttps://t.co/HGyjNwCm0vhttps://t.co/tcGQ0D9aM9

2022-07-11 14:13:30 Discussing the BA.5 variant status with @rosemaryCNN last evening https://t.co/XuLT6zp8XT

2022-07-11 14:03:55 RT @chrischirp: Quick Thread on Covid update in England:Firstly BA.5 and its child BA.5.1 are now the dominant variants and outcompeting…

2022-07-11 13:38:28 What country has a lower booster rate than Iran, Rwanda, Sri Lanka, Azerbaijan, Tajikistan and 61 others? https://t.co/gWCbSb6EfDThe United States

2022-07-11 13:24:33 RT @ddiamond: “BA.5 has taught us once again, the virus doesn’t just get milder and fade away,” @EricTopol writes. “While the virus revs up…

2022-07-11 02:44:04 There's a lot going on with the Omicron BA.5 variant. I wrote a new chapter to update its status https://t.co/ibgdJ7yYlI

2022-07-10 23:49:56 The double whammy of immune escape and increased infectivity

2022-07-10 18:14:53 "BA.5 could mediate not only extensive cytopathiceffects but was also significantly more infectious per diagnostic Ct value compared to the co-circulating BA.2 parental variant.""Appears to have evolved tropism towards pre-Omicron [cell] entry pathways"

2022-07-10 18:14:52 on BA.5 biology"Curiously, the change in BA.5 not only gives the virus greater antibody evasion potential but concurrently has changed its tropism [efficient use of TMPRSS2] along with an increased transmission potential in the community."https://t.co/U0r0ms6Mr7 https://t.co/qgCKTCHKTb

2022-07-10 17:43:58 We desperately need #LongCovid biomarker(s)Many reports show persistent virus antigens, such as this recent small onehttps://t.co/nlrgzWIscM but a few counter https://t.co/pKFX1d7cTfWith millions suffering LC, it's long overdue this gets nailed down w/large, definitive studies https://t.co/kvJFDAMEjE

2022-07-10 16:52:44 https://t.co/czSashfSGL

2022-07-10 16:52:43 An obstetrician writes about post-Roehttps://t.co/5TVVK8X8JO by @DavidNHackney @nytopinion https://t.co/F25ybClbjy

2022-07-10 15:53:35 The @uk_biobank brain study was quite concerning, so this new report is reassuring and welcome. We’ll need more high quality longitudinal studies (like these two) with extended follow-up to sort this out.

2022-07-10 15:20:39 The waste of 1.1 billion Covid vaccines that could have done a world of good to reduce deaths, hospitalizations, sickness and #LongCovid https://t.co/LXSEZObiu4 by @hannahkuchler @FT

2022-07-10 15:05:01 "America has decided the pandemic is over. The coronavirus has other ideas."https://t.co/5uRqAbZ14v by @JoelAchenbach

2022-07-09 23:16:00 @kallmemeg @profesterman @guardian Meaghan, Thanks for your post. I shared @profesterman's piece (an epidemiologist) for his perspective (not mine), which is not in my summary of BA.5 https://t.co/vwK1ZXsU7m.No intent to mislead. I will delete it and let him defend his calculation

2022-07-09 23:07:06 https://t.co/F5uXha5j3w

2022-07-09 23:07:05 Brain imaging &

2022-07-09 18:47:56 Coverage of the new @ONS UK reporthttps://t.co/QuPCZO0kpy @FT @SarahNev w/ comments by @LawrenceYoung11Report https://t.co/Fsb4G7mIKR https://t.co/68AGghg7m9

2022-07-09 18:19:37 BA.5 got started in S. Africa and Portugal. Besides affecting much of Western Europe and the US now, it is leading to new surges in the Asian-Pacific region and South America. In most regions deaths have remained low to date@OurWorldInData https://t.co/CbO1qpeuwA

2022-07-09 01:53:58 The @CDCgov twitter post todayhttps://t.co/Mp2Tfrx5Q0

2022-07-09 01:18:06 @scrivenix Much appreciated

2022-07-08 21:13:40 A systematic review of 43 studies on post-Covid reinfections from 17 countries. Pre-Omicron protection was very high and durable (Left panel)Post-Omicron: substantially lower and declined more rapidly (Right panel)https://t.co/YOFrTTAKzc by @IHME_UW https://t.co/blooSrvaFC

2022-07-08 20:55:54 BA.5 signs on in JapanNearly as vertical as Omicron BA.1, and despite a big BA.2 wave@OurWorldInData and https://t.co/t6RYIZYbFE https://t.co/9Is3zGNZt7

2022-07-08 20:39:23 Link to the @CDCgov site which provides "community level" virus by county, a deceptive and hazardous view of our BA.5 situation now. Hidden behind that on the site is the "community transmission level," as previously shown (and below)https://t.co/cp8qDLJbEn https://t.co/ujP2kooI9J

2022-07-08 20:11:20 @Jlguest Thanks Dr. Guest

2022-07-08 19:14:59 RT @mehdirhasan: Embarrassing. Shameful. Inexcusable.

2022-07-08 18:07:29 New and outstanding @SciImmunology review on #LongCovid and other respiratory viral infection chronic sequelae with particular attention to lung impact https://t.co/iivxZXQIc5by @hnarasim23 @Jie_Immunology @goplenNP @Yue_Wu_IMM @UVA_MIC @MayoClinic https://t.co/ZzuQ95YDlL

2022-07-08 17:17:11 Reference for survival advantage of a 4th shot (2nd booster) for age 50+ (besides 2 Israel @NEJM reports)https://t.co/HGyjNwCm0v https://t.co/TqusVj3d8l

2022-07-08 17:17:10 Reference for 5 days as median for length of infectiousness (best proof is not a rapid test but how long the virus can be cultured)https://t.co/OSIzRKxt33

2022-07-08 16:46:27 This is our @CDCgov X No warning on BA.5X Still says 2 vaccine doses ="fully vaccinated"X Says 5 days is all that's needed for isolation when 5 days is the median length of infectiousnessX 1 in 4 age 50+ w/ 2nd booster (<

2022-07-08 15:56:18 @cellhostmicrobe More on BA.4/5 immune escapehttps://t.co/7yDUJ5vTxqWith simplified street-sign view of its antigenic distance from prior (sub) variants that account for this property https://t.co/pmEH6HvurU

2022-07-08 14:19:30 Meanwhile, here in Californiahttps://t.co/2hpenSZ59k https://t.co/uyNSsW3mgr

2022-07-08 13:57:04 Despite the >

2022-07-08 13:57:03 Why is it the "worst variant" yet?Not because it causes worse disease. There is no evidence for that.Because it is the most transmissible and most immune-evasive of any version of the virus since the pandemic began.https://t.co/vwK1ZXsU7m

2022-07-08 13:34:54 Today's @nytimes BA.5 variant coverage by @LaurenLeatherby https://t.co/DUxqHMgHGz https://t.co/SIeCseZm37

2022-07-08 13:28:23 Today's @washingtonpost editorial on the BA.5 varianthttps://t.co/HLRpQSYBNG https://t.co/eNm00RbBxE

2022-07-08 04:03:06 @mocoband @LaurenLeatherby Yes, thanks. Introduced in Mayhttps://t.co/P7KQmSc8qK

2022-07-08 02:49:51 @mattyglesias @dgmacarthur Agree with @patrickc for what is holding us back. It's not the science, as we wrote about in early 2021https://t.co/eKHGg7EPtM @Nature

2022-07-08 02:45:06 RT @michaelmina_lab: Goes without saying at this point…Test before exiting isolation to know you are no longer infectious(Do not listen…

2022-07-06 23:29:28 It's not just about cases https://t.co/PPN3yKhOXf

2022-07-06 23:26:10 Some countries, like Singapore, have already hit 2nd highest case peak after Omicron BA.1 https://t.co/JEUTK7Kp0Z

2022-07-06 23:26:08 Broadening impact of BA.5 around the world https://t.co/kkpT6Zgodr

2022-07-06 23:10:36 Pharmacists in the US (>

2022-07-06 21:01:00 Understatement:"The rapid emergence of new variants makesvariant-specific vaccine development dificult" https://t.co/kLAuVbkDps@NEJM todaya.k.a variant chasingPan-β-coronavirus and nasal vaccines would avoid V-chasing and can help get is to variant-proof status, ahead of https://t.co/fIsYc3bdlK

2022-07-06 17:33:20 @LeanneGSinger @AshishKJha46 Agree! Instead of throwing away tens of millions of vaccines about to expire, they should be distributing 4th shots to all who want them

2022-07-06 17:22:39 Genome editing for potential definitive treatment or curies for many genetic conditions is moving forward at high velocity. A new @CellCellPress review is a masterful state-of-the-science for deliveryhttps://t.co/SJtJ512NE1 @davidrliu @samagyabanskota @liugroup @broadinstitute https://t.co/jYdghFsF3s

2022-07-06 14:14:15 Such profound waste of tens of millions of vaccines that could have saved lives, prevented hospitalizations, sickness and #LongCovid ⁦@Loftus⁩ https://t.co/qF8324imGG

2022-07-06 13:41:55 The kind of forward thinking needed to get ahead of the virus, by @CalTech @bjorkmanlab https://t.co/wpLKJ7lgDf@ScienceMagazine Nanoparticles with multiple different #SARSCoV2 receptor binding domainshttps://t.co/EAsUdng9Jx @corinnepurtill @LATMelissaHealy @latimesscience https://t.co/kOPV9d8loA

2022-07-06 13:30:17 Collateral impact of a post-Roe United States—In vitro fertilizationhttps://t.co/5WTmZQp7Zsby @JanHoffmanNYT —Prenatal genetic testinghttps://t.co/4Qmct1kcYY @CellRepMed by @MAllyse and @MarshaMichie https://t.co/nKZuGhc64G

2022-07-06 13:18:35 More on this from brain neuroinflammation in 24 patients and matched controlshttps://t.co/t8JQqSx5B8 5 severe Covid patients had #SARSCoV2 immunoreactive neurons in brainstem nuclei https://t.co/GzfT2gjVMF

2022-07-05 23:42:26 The microvascular injury and inflammation of the brain, with immune complex formation, that can occur from Covid, from in-depth assessment of 9 patient autopsies and controls. https://t.co/AWbo70nrBK by @NINDSnews https://t.co/oiBC8lXygI

2022-07-05 23:03:26 US CDC genomic surveillance updateBA.5 growth marches on, now 54%BA.4/5 combined >

2022-07-05 15:05:04 For both 2020 and 2021, Covid was the 3rd leading cause for death in the United States, by @theNCI @JAMAInternalMed In 2021, it was the #1 cause of death in Americans age 45-54 https://t.co/hFcvKAomER https://t.co/pH8sBTbLz5

2022-07-04 19:01:00 Hello BA.5 https://t.co/kZK5Ss0Ofh

2022-07-04 18:17:21 RT @shannonrwatts: Having unfettered access to 400 million guns isn’t freedom. Being able to take your kid to a Fourth of July parade witho…

2022-07-04 16:57:38 The promise of individualized medicine for systemic autoimmune rheumatic diseases https://t.co/CS5TbPUmqL A new @NatureMedicine review@guthridgej @OUHealth @OMRF https://t.co/Y1qOLMZCs1

2022-07-04 16:34:16 —I'd like an inhalable Covid vaccine with exosomes decorated by #SARSCoV2 receptor being domain—Sure, here it ishttps://t.co/RSBJaVNzm0 @NatBMESeriously, we need nasal spray vaccines

2022-07-04 15:39:32 If you're into #AI for healthcare, an essential new review article @natBME today https://t.co/3F0row83l6@Joseph_C_Wu @james_y_zou Angela Zhang @StanfordMed @StanfordCVI https://t.co/ljeO8Mji7J

2022-07-04 15:08:29 The basis for concern about the Omicron BA.2.75 variant. 8 mutations beyond BA.5, many in the N-terminal domain, which could make immune escape worse than what we’re seeing now. Competing w/ BA.5 in India. Excellent thread by @EllingUlrich https://t.co/Ko5AYxEonv

2022-07-04 14:50:22 @mebottazzi Congratulations for this richly deserved recognition!

2022-07-04 14:38:21 Celebrating Great Immigrants, Great Americans, the essential contributions of immigrants to American LifeSuch as @ardemp &

2022-07-04 03:49:38 RT @Bob_Wachter: Covid (@UCSF) Chronicles, Day 838The die is now cast: BA.5 is destined to be our dominant virus. In today’s I discuss t…

2022-07-04 01:22:02 RT @deschiam: If you do nothing else please read this. I get the fatigue but this is not doom and gloom. There is a path out but we have to…

2022-07-03 17:20:11 Relevance to Omicron infections"Omicron infection had little or no beneficial effect of boosting any part of the immune system — antibodies, B-cells or T-cells — among people who had been imprinted with earlier #SARSCoV2 variants"https://t.co/PE4QjMv69U@ScienceMagazine

2022-07-03 16:43:08 Impact on optimizing boosters, timing, and next-generation of Covid vaccines"Patterns of anti-spike immunity in different people and populations have become heterogeneous, complex and unpredictable"by @clivecookson @JamieSmythF @ian_bott_artist https://t.co/z4dT40Fwjy

2022-07-03 16:43:07 What is immune imprinting and why it is important?A superb explainer“Our first encounter with the spike antigen, either through infection or vaccination, shapes our subsequent pattern of immunity through immune imprinting" —@BoytonRosemaryhttps://t.co/OYMd5RRe1j https://t.co/8hfXjGno29

2022-07-02 23:28:27 Small study of health care workers suggests possibility that there may be increased protection from #LongCovid with increased doses of vaccine https://t.co/1tBWtHdsJM ⁦@JAMANetworkOpen⁩ https://t.co/n0OhnsxTRL

2022-07-02 20:50:29 @RajlabN @Mike_Honey_ Thanks. But I’m referring to sign of growth of BA.2.75 here. Not 2 isolates. We’ll obviously be seeing more if it in the days ahead

2022-07-02 19:13:09 Connecting the dots for these 2 sequential @KPSCalResearch reportsVaccine effectiveness vs hospitalization, 3 mRNA shots, <

2022-07-02 18:13:38 Omicron subvaraints in the US—BA.5 is likely >

2022-07-02 17:09:46 @DianaGHealth @MiamiDadeCounty Yes, concerning, and across the US test positivity only exceeded during initial Omicron wave

2022-07-02 16:45:00 Be careful out thereOn the way up. US Covid cases, hospitalizations and deaths. BA.4/5https://t.co/QPRo6jaOkahttps://t.co/g9qEGacIrz https://t.co/4230aNMcKj

2022-07-02 16:24:03 The same @KPSCalResearch group previously published their data with 2 or 3 mRNA shots over time for Delta and Omicron. Vaccine effectiveness vs hospitalization vs Delta was 89% (95%CI 83-93) for <

2022-07-02 16:24:02 A reminder that prior to Omicron vaccine effectiveness with 3 mRNA shots vs symptomatic disease (and hospitalization) was ~90% for at least 3 monthshttps://t.co/pKg2TyidP5@ScienceMagazine w/ @GuptaR_lab https://t.co/B9RwRzyfCV

2022-07-02 15:57:05 The need for better vaccines vs Omicron subvariantsReduction in 3-shot mRNA vaccine protection vs Emergency Department admission from BA.1 to BA.2 (5% at ≥ 3 mos) https://t.co/mxSyJaHRmN3-shot vaccine effectiveness vs hospitalization 80% BA.1, 74% BA.2 at <

2022-07-01 20:21:16 RT @EricTopol: Has the @CDCgov warned you about BA.5, now accounting for ~37% of Covid cases, a liability for reinfections, less protection…

2022-07-01 17:58:16 I guess the CDC woke up today on thishttps://t.co/hmQq0numog

2022-07-01 17:01:01 RT @john_actuary: Another 39% increase in today's admissions figure, to 1,572, bringing the weekly average to 1,290, itself up 34% on the w…

2022-07-01 16:47:13 "It is both perplexing and not a little devastating that this mysterious, lingering disease finds a way to continue wreaking havoc in the face of a largely vaccinated population and a supposedly milder variant."—@Daltmann10 https://t.co/NbWldSRi0Q @guardian via @JeremyFarrar

2022-07-01 15:39:50 The importance of investigating unexpected findings:the role of a silent KRAS gene variant in cancerhttps://t.co/J1MjkFTbZa by @molina_arcas @JulianDownward @NEJM https://t.co/51sToFMIxH

2022-07-01 15:23:51 Hospitalizations for croup in children with Covid rose substantially with Omicron BA.1.1https://t.co/3b9qQ0COxf @JAMANetworkOpen https://t.co/TsbMaY8S7J

2022-07-01 14:55:01 How does BA.5 spread so fast and what we can do about ithttps://t.co/vwK1ZXsU7m

2022-07-01 14:46:06 The rise of BA.5 globally https://t.co/OoY95naYJp https://t.co/ru4EuNrlAV

2022-07-01 14:34:40 The BA.5 variant: here, there (UK) and everywhere, on a path to global dominancehttps://t.co/drfdJlqjOM @clivecookson @FT https://t.co/3B9h8mrm5w

2022-07-01 05:06:51 RT @JPWeiland: Positivity rates have only been higher two times since the beginning of the pandemic. The first weeks of the pandemic, and…

2022-07-01 00:45:58 RT @AI4Pathology: Our @TheLancet perspective w/ @EricTopol highlights key findings from our recent @NatureMedicine article about AI-driven…

2022-06-30 22:57:49 Can #AI promote accuracy of diagnosing organ transplant rejection?Our new @TheLancet essayhttps://t.co/0kLA0JlBrpw/ @AI4Pathology @BWHPath @harvardmed @broadinstitute and their colleagues recent work https://t.co/KgDBuwDlgc @NatureMedicine https://t.co/piSnqdtn2b

2022-06-30 22:39:03 The 3 figures from the study to convey these 2 points https://t.co/ygFwdSJWqI

2022-06-30 22:34:55 Largest study of BMI and Covid vaccination—Underweight/low BMI less likely to get vaccinated + severe disease risk after 2nd dose higher in than in people w/normal to high BMI (need 3rd shot)—Obesity did not impact vaccine effectivenesshttps://t.co/nrEtKhwowK @TheLancetEndo https://t.co/X8I4xEBSbI

2022-06-30 20:25:54 Impact of "The hiatus of the handshake"https://t.co/ML50IIZvDV @ScienceMagazine @kbratnelson @B_Lopman @EmoryRollins @EmoryEPI A thoughtful essay on what we've learned from the pandemic, the rippling effects on other infectious diseases spread, &

2022-06-30 20:18:22 How it's going hereHospitalizationsICUsDeaths https://t.co/q39jhVwoiP

2022-06-30 18:53:24 It seems like almost every day there is another major discovery of broad, neutralizing antibodies to #SARSCoV2 that could be the foundation for pan-β-coronavirus vaccinesYesterdayhttps://t.co/53pFFnNx9gTodayhttps://t.co/rGEXabRCJF https://t.co/qANrWz3ybF

2022-06-30 18:47:20 A new, tour de force review of the gut microbiome and its implications for health and disease https://t.co/jOIuUaF60l @ScienceMagazine @abaumler @TsolisRenee @Jeeyon84 @ucdavis https://t.co/0R94eGpbt4

2022-06-30 16:37:29 @RobertoBurioni @ScienceMagazine @NewsfromScience @RobertFService Hope you are right, RobertoSince the potential exists, it would be ideal to have other drugs and combinations ready

2022-06-30 16:07:51 Here's the US Covid hospital admissions, log-scale, with BA.5 on the rise https://t.co/icf7bUryc4

2022-06-28 16:57:53 RT @Bob_Wachter: Great BA.5 primer by @EricTopol. Key points:1) Will be dominant variant soon2) infectious &

2022-06-28 15:16:51 @buzzindelhi @DrAmbrishMithal Yes

2022-06-28 15:13:46 Maternal mortality in the United States, highest of all 38 @OECD countries, increased during the pandemic and now, with banning of abortion in many states, is positioned to go even higher, w/ disproportionate impact by race and ethnicityhttps://t.co/HwPyEHs6ty @JAMANetworkOpen https://t.co/NBlQEm0M5m

2022-06-28 14:55:19 The comprehensive list of the actions taken during the pandemic to get ahead of the virus https://t.co/QxKHUKCz9v

2022-06-28 14:46:01 Note there is no BA.1 while the @US_FDA Advisory Committee debates today the merit of an EUA for a BA.1 booster that has a 3-fold drop in neutralizing antibodies vs BA.4/5https://t.co/6X3AwmEfol https://t.co/18vu12n7e4

2022-06-28 14:31:58 The BA.5 variant is now 37% of Covid cases in the US, and the BA.4/5 combo has now overtaken BA.2.12.1 to become dominanthttps://t.co/jjl2AnwOWX https://t.co/7xWs8tKUfb https://t.co/K6FuxPaxP2

2022-06-28 14:11:11 10 years ago today a @ScienceMagazine online paper with an obscure title turned out to be the beginning of the most important life science breakthrough in many decades: #CRISPR genome editinghttps://t.co/y23NPGumVV @carlzimmer https://t.co/gO4JoMgUkA

2022-06-28 02:20:03 This variant is center stage for the @US_FDA Advisory Committee hearing tomorrow about updating vaccines and the question of (EUA) approval of an Omicron (BA.1) booster (a variant that is no longer circulating)https://t.co/eHgCgUvnO0 by @SharonLNYT

2022-06-28 02:11:33 When it comes to #SARSCoV2 and Covid, it's important to keep your eyes on the ball. The ball is BA.5 and here is what we know about ithttps://t.co/vwK1ZXsU7m https://t.co/qaH1eTdqPO

2022-06-27 21:18:58 RT @chrishendel: "It’s frankly sickening to watch this virus continue to outrun us, knowing we are so damn capable of getting ahead of it"…

2022-06-27 20:51:08 I wrote about about the Omicron BA.5 variant: (1) what we know about its biology

2022-06-27 16:08:16 A new outstanding review on the antibody response to #SARSCoV2 https://t.co/7NbLF1HBQy @NatImmunol and the path to variant-proof Covid vaccines https://t.co/hnZnCnyzYr

2022-06-27 15:15:55 The promise of digital health. Our new @theNAMedicine perspective piecehttps://t.co/SfNm1YwuAu "A digital health ecosystem that provides high-quality, personalized, equitable care to all who need it is achievable and worthy of our best individual and collective efforts." https://t.co/8jE2J5OTjr

2022-06-27 14:05:42 Canada has done remarkably well throughout the pandemic compared with peer countries (G10) for major outcomes and vaccinations https://t.co/nJflYNqLHY @CMAJ https://t.co/3lWZOii6iQ

2022-06-26 17:35:28 A timely an important update, thread from @jburnmurdoch on this https://t.co/EA7K4i81wn

2022-06-26 17:26:11 As the world turns to BA.5 https://t.co/cqbVuPTjp8

2022-06-26 15:09:00 BA.5 has the most transmissibility and immune escape of any version of the virus since the pandemic began. Although its spike(S) sequence is nearly the same as BA.4, there are several mutations in other parts of the virus that may account for itsfitness https://t.co/nKnmp5OBZK https://t.co/dUsPxu2LIL https://t.co/9feAvwKAMY

2022-06-26 14:45:10 @thehowie That's incredibly kind of you, Howie. Deep thanks!

2022-06-26 14:41:53 This is the simple graph that should have been in the paper, #dataviz from @TheEconomist for saving ~20 million lives in the first year of Covid vaccinationshttps://t.co/bFNPnYyPCd @ECONdailycharts https://t.co/7WDD0YoJ4O

2022-06-25 19:48:49 RT @IAmPoliticsGirl: A court that abandons its own precedent, undermines its own authority. https://t.co/uZOtzRYQtX

2022-06-24 19:12:14 The BA.5 variant is a beast w/r to immune escape and transmissibility—UK report today on its growth advantage relative to BA.2.12.1 and BA.4https://t.co/VW6RafyHNK—San Diego wastewater todayhttps://t.co/rqPGc1qN24 https://t.co/D695PIeDFb

2022-06-24 16:49:54 A real CDC would be aggressively disseminating these data and doing everything possible to prevent unnecessary deaths from Covid https://t.co/Qj3lAZ8K4y

2022-06-24 15:33:11 "The editors of the New England Journal of Medicine strongly condemn the U.S. Supreme Court’s decision."https://t.co/m4wmq0ipFz https://t.co/NZa3rGpEYl

2022-06-24 15:15:35 RT @EricTopol: This week @TheLancet's cover https://t.co/Fnj8uzkJTn

2022-06-24 14:26:27 RT @luckytran: Today, the CDC Director flippantly dismissed the importance of counting rapid tests."You don't need to count the rain drop…

2022-06-24 14:17:44 @clivecookson @alexisak @OurWorldInData @FT @jburnmurdoch @JamieSmythF Thanks Clive. Yes, well shown here https://t.co/zEKob7UFZr

2022-06-24 14:12:01 the bigger picture https://t.co/RQtShVeZsi

2022-06-24 13:57:20 @alexisak @OurWorldInData @FT @jburnmurdoch @JamieSmythF Yes, I cited ithttps://t.co/pu7tSg4YwBBut a lot more is happening since then (and beyond Europe) attributable to BA.4/5

2022-06-24 13:31:13 The rise of BA.5 in Israel https://t.co/zMQih3Ym2g

2022-06-24 13:12:13 Not just England. The BA.4/5 wave in Europehttps://t.co/TMJf6Au4cJ and @OurWorldInData https://t.co/xs8gY8MLSQ

2022-06-24 01:46:18 RT @EricTopol: New @CDCgov data on 2nd booster protection from death for people age 50+, compared with unvaccinated, through Omicron BA.1,…

2022-06-24 00:05:47 "Trust in science has actually become a matter of life and death.”—@NaomiOreskeshttps://t.co/qCmowtRfHI @TheLancet Cover and profile of Professor Oreskes https://t.co/DMeuvBJjgF

2022-06-23 22:30:00 @TheLancetInfDis In the 1st year of Covid vaccinations, ~20 million deaths were prevented worldwide (data from 185 countries)Another ~600,000 lives would have been saved if the @WHO 40% target been achievedhttps://t.co/BWig83xlnN @azraghani @imperialcollege @MRC_Outbreak https://t.co/lF8biBJIlK

2022-06-23 21:57:17 A new study of the "atomic-level dynamics by multiple microseconds simulations" for how the #SARSCoV2 spike gets modified to more efficiently enter host cellshttps://t.co/Pybvy05L2q@PNASNews https://t.co/Z1Q3cPpP86

2022-06-23 19:10:46 Just out @ScienceMagazine "Our findings highlight the urgent need to find next-generation COVID-19 vaccines and broad-spectrum therapeutics, as well as to tighten non-pharmaceutical measures to reduce acute and chronic disease burden (#LongCovid)..."https://t.co/LGBn3krkEf

2022-06-23 19:06:08 The antigen distance map of #SARSCoV2 variants through BA.1 and BA.2 "BA.1 and BA.2 both escape vaccine-induced antibody responses as a result of different antigenic characteristics" Needs a BA.4/5 update, off the chart https://t.co/GGYW6AaMdF @SciImmunology https://t.co/GoE6YC14wz

2022-06-23 18:32:43 A bacteria, as a microbe, is expected to only be visible via a powerful compound microscope. Until this one that was discovered to be macroscopic, reported today @ScienceMagazine https://t.co/KjRYmaU1hA @PetraLevin Easy to remember its name if you like very large margaritas https://t.co/VzeWmuyMM4

2022-06-23 17:56:40 @AstroKatie No good reason. See US hospitalization data by age groups https://t.co/M2Bu9rj1Ve

2022-06-23 17:35:09 https://t.co/ibU6PHvkpR

2022-06-23 17:35:08 The Israeli researchers nailed this down back in February and have published extensively on the protection of the 4th shot for reducing death and severe diseasehttps://t.co/W4xkPskVdP

2022-06-23 16:23:17 Only 1 in 4 Americans age 50+ have had a 2nd booster. https://t.co/k1hTZD8CciPlease go for it. It could be lifesaving.

2022-06-23 16:19:26 New @CDCgov data on 2nd booster protection from death for people age 50+, compared with unvaccinated, through Omicron BA.1, BA.22 boosters: 99% reduction 1 booster: 86% reductionVaxx, no boosters: 81% reductionhttps://t.co/HGyjNwCm0v https://t.co/yaEtuClQA5

2022-06-23 16:07:49 RT @kallmemeg: A little sent me these. The BA.4/5 wave is here… https://t.co/ojQ7b2TNgQ

2022-06-23 16:04:22 The trajectory in Englandhttps://t.co/UzmuMktkq5

2022-06-23 15:48:42 More @TheEconomist today on @mcuban's @costplusdrugs and @CivicaRx efforts to take down drug costshttps://t.co/jJH6hmH3sq https://t.co/iiRyMe6QKZ

2022-06-23 14:51:28 On the amazing 300 million smell receptors in dogs that can sniff out Covid and diseaseshttps://t.co/f6opxKX7lU@nature @PVWDCvet @juliannaphos https://t.co/oY89CE4O4o

2022-06-23 14:22:57 A new systematic review of #LongCovidKids https://t.co/GP73U57KOb https://t.co/8IVwtzpwXl

2022-06-23 02:42:26 A few added mutations in the spike sequence (BA.4/5) are leading to even more immune evasiveness and a new Covid wave in many places around the world https://t.co/xMlXAyb6VY

2022-06-23 01:44:40 "Astoundingly, they found that more than 78% of all the CTCs obtained were from the samples taken during the resting [sleep] phase."https://t.co/nQVG1s5pLA@NatureNV https://t.co/eJZbKkU2gT

2022-06-23 01:34:39 The exact opposite:@VirusesImmunity tips for 1st rate science communication on @Twitter https://t.co/qPqFWGJBCs@NatImmunol https://t.co/0cZSsalGfC

2022-06-22 22:57:27 Accompanying editorial https://t.co/u28w8wyG6Pby @skr9skr9 and Denise Jamieson https://t.co/XHa1dBDX7X

2022-06-22 22:30:13 Largest study of #LongCovid in kids, a nationwide Denmark report with age-sex-matched controls @LancetChildAdol Higher odds of >

2022-06-22 21:49:14 How vaccinating 1 person protects 2Expectant mothers and their newbornshttps://t.co/CgARnJzAab https://t.co/BH0VOBuBDT

2022-06-21 21:43:55 A new report on Covid reinfections is particularly concerning. I've written about it here https://t.co/2dRK90OeoV

2022-06-21 19:11:55 The link to this important report is now active https://t.co/iOHqC3ulET

2022-06-21 18:09:47 A wake-up call for drug-gene interactionshttps://t.co/CufZhaKPp9by @CeciliaChung11 and colleagues @VUMChealth @VUMC_Medicine @VUMCClinPharm https://t.co/Cm6nK5Ji0X@AnnalsofIM https://t.co/3TV4Ztl2Iz

2022-06-21 17:00:13 New @CDCMMWR reports Real world evidence for Paxlovid efficacy, striking increase in prescriptions, and their mismatch in places of high vulnerability/needhttps://t.co/HCMlSrgrK4https://t.co/NB76ONZDPi https://t.co/ScUIGIQbum

2022-06-21 16:22:26 Sorry, meant to link this risk of reinfection paperhttps://t.co/AiV7P6hQLO

2022-06-21 16:18:49 Before Omicron the chance of reinfection was ~1%. That has markedly increased w/ Omicron, especially for BA.4/5 with reduced protection from BA.1 infections. Reinfections carry substantial risk, as shown in this new analysis, so please keep your guard uphttps://t.co/Rx6p2lLw66

2022-06-21 15:28:32 The BA.4/5 impact is just starting to take hold, with no region of the US at a dominant level yet. It is also on a path to dominance in multiple countries in Europe, and Australia, with some attributable increases in hospitalizations https://t.co/pu7tSg4YwB https://t.co/CO1gfjwKSQ

2022-06-21 15:23:01 BA.4/5, the Omicron subvariants with the most immune escape (and highest transmissibility) since the pandemic began, now account for 35% of new cases in the United Stateshttps://t.co/jjl2AnwOWX https://t.co/teIGeGTUVC

2022-06-21 15:01:58 Americans spent ~$50 billion on vitamins and supplements in 2021. A new systematic review of 84 studies shows they are a "waste of money," lacking value in non-pregnant adults, and specifically risk of beta-carotene and lack of Vit E effect @JAMA_current https://t.co/mTPSw1u7kp

2022-06-21 14:36:06 Having so many new and repeat infections during a prolonged Omicron subvariant wave (BA.2.12.1, BA.4/5) with their toll on sickness and #LongCovid should not be comforting or give anyone the impression this is behind ushttps://t.co/FrGtjbmmf2 https://t.co/8WzkZSI2FD

2022-06-21 14:24:54 For those questioning about peer review, these authors have published extensively on Covid cardiovascular outcomes https://t.co/bCXl6MEeP0, breakthrough infections and #LongCovid https://t.co/2JUuTasGDVdiabetes, mental health, kidney disease, and morehttps://t.co/mT5sylrfy4

2022-06-21 01:27:07 RT @mcuban: Hey @JoeBiden , @LeaderMcConnell, @SpeakerPelosi , @GOPLeader, @SenSanders @RonDeSantisFL @AOC have your people call my peop…

2022-06-21 01:19:30 Covid reinfections are not benign: ~39,000 people w/reinfections vs ~5.4 million controls indicates extensive and persistent risk with a "dose-response" (more risk with repeat reinfections) https://t.co/v8nZXBEuNdby @zalaly @BCBowe @Biostayan @WUSTLmed @VAResearch https://t.co/U4pPQZLEaB

2022-06-21 00:21:08 Text and more data from the reportNote the vaccines that participants had received were Sinopharm (BBIBP-CorV) and Anhui Zhifei Longcom (ZF2001) https://t.co/jKAs8p4hIb

2022-06-20 23:58:35 Post-vaccination breakthrough infections with Omicron subvariants (BA.1, BA.2) lead to a narrow, specific neutralizing antibody response setting up vulnerability to BA.4/5 https://t.co/Kf7hDxZaf1 @TheLancetInfDis https://t.co/gkwj8XpVIX

2022-06-20 21:27:35 The new paper was based on <

2022-06-20 21:17:53 Table from the paperAnd https://t.co/sH9CNbZPAlExamples for 2 of the most frequent drugs I prescribe vs retailLisinopril for BP ($3.60 vs $24)Atorvastatin ($3.60 vs $55.20) https://t.co/V5EK6vCb9h

2022-06-20 21:10:04 The many $ billions the US could save each year by @mcuban's @costplusdrugs (MCCPDC) is remarkablehttps://t.co/3vVXM2TbnL@AnnalsofIM @BrighamWomens by @DrHussainL @PORTAL_Research @akesselheim @bnrome https://t.co/eyGwDewo1x

2022-06-20 19:34:35 Speech and spread of #SARSCoV2 "Our results suggest that the quantity of speech aerosol, in particular in the ≥ 4-μm range, may have been strongly underestimated in many prior reports"https://t.co/z4z0xj4h3g <

2022-06-20 19:07:19 "What SARS-CoV-2 does to our brains"https://t.co/8c7ORLBvgr @ImmunityCP potential of immune systems response both acutely and w/ #LongCovid @HelenaRadbruch @f_heppner @ChariteBerlin https://t.co/ktFYe6QHlS

2022-06-20 17:58:35 Deep learning #AI to rapidly identify new driver mutations in 37 types of #cancerhttps://t.co/C6V85OgfSjby @MIT_CSAIL @lab_berger @m_a_sherman @olivercpriebe @AdamYaari @NatureBiotech https://t.co/SQCdzRFZBS

2022-06-20 17:43:14 “I don’t think there can be any doubt in anyone’smind that these are a source of new variants”—@GuptaR_lab https://t.co/YXiaN6j12K @Nature by @ewencallaway https://t.co/xBoipvrpT8

2022-06-20 17:37:55 RT @NatureBiotech: Smartphone apps in the COVID-19 pandemic https://t.co/0VLZ5LGAVQ https://t.co/oyfsFNHPLo

2022-06-20 16:12:42 The role of digital surveillance and real-time individualized risk assessment throughout the pandemic has not been adequately emphasized

2022-06-20 16:00:54 The evolution of #SARSCoV2 in immunocompromised people with chronic infections is driven by immune evasion, especially seen w/ viral rebound, and requires extensive genomic monitoring for detection of new VOCs @NatureMedicine https://t.co/GFK4nW10Lj https://t.co/cNF1ivKViU

2022-06-20 15:12:55 Just published @NatureBiotechOur review of smartphone apps for Covid-19: outbreak epidemiology, individual screening, contact tracing and their futureby @JayPandit @jmradin @GiorgioQuer @ScrippsRTI @scrippsresearch https://t.co/NswHMmNmRl https://t.co/9pNO2VCnde

2022-06-19 16:14:33 How the pandemic is catalyzing innovations1. https://t.co/G5aKL6z8IX @NatureMedicine 2. https://t.co/6l2aW15kRF3. https://t.co/KUc1KWIyQP https://t.co/U8xnQc8JoC

2022-06-18 21:25:39 RT @Medscape: .@EricTopol speaks with @DeepMind CEO @demishassabis about harnessing the potential of AI in health and medicine. https://t.c…

2022-06-18 16:51:09 How can you go from sequence of a novel virus to 2 vaccines with 95% efficacy and safety (>

2022-06-18 16:43:11 ‘Why aren’t we having a vaccine...that gives you a 5- or 10-year duration of protection like most vaccines?"— @PeterHotez

2022-06-18 16:43:10 ‘‘In terms of what really keeps me up at night, it’s the knowledge that we can’t keep boosting."—Dr. Peter Marks @US_FDAhttps://t.co/gLmtGp2WTf by @StephArmour1 https://t.co/j22vTDxmDo

2022-06-18 15:11:18 Concerns echoed herehttps://t.co/4VT2MQVphu"Uğur Şahin warned that a sub-variant of Omicron that fully escapes vaccines’ protection might emerge as countries prepare to launch autumn booster campaigns"@hannahkuchler @JamieSmythF https://t.co/RwBbG1nDih

2022-06-17 19:12:07 More on this from @chrischirp @bmj_latest https://t.co/S0MsyPqwJV https://t.co/sSYi3djtey

2022-06-17 17:01:47 Parts of the text https://t.co/aPjzqIc5lI

2022-06-17 16:56:44 The Omicron BA.4/5 subvariants are leading to a new wave in Europe and the United States, with an impact of some increase in hospitalizationshttps://t.co/y0LvkzoCRb @SarahNev @JamieSmythF @jburnmurdoch @TWenseleers https://t.co/pBuS7Xc5Li

2022-06-17 16:41:58 A noteworthy failure of individualized medicine (or amyloid hypothesis) for prevention of Alzheimer's disease: a randomized, placebo-controlled trial of a monoclonal antibody for people w/ presenilin 1 mutation (amyloid precursor) failed to show benefithttps://t.co/e5cwN4UIsY https://t.co/KAG3AjfpQZ

2022-06-17 15:18:31 Just published @Nature The extent of immune evasiveness of Omicron subvariants BA.2.12.1 and BA.4/5 raises concern about effectiveness of the Omicron (BA.1) specific vaccine booster impacthttps://t.co/foDTHDo49p https://t.co/2WmXQHmRwr

2022-06-17 15:08:07 Oh, really?

2022-06-17 03:11:51 A review of what we know about 3 theories that may represent underpinnings of #LongCovid @ScienceMagazine: (1) microclots, (2) persistent virus, and (3) immune system gone haywirehttps://t.co/KuY8N9dVp6

2022-06-17 02:40:13 Substantial (~50-75%) reduction of #LongCovid with Omicron compared with Delta variant, magnitude influenced by age and time since vaccination @TheLancet https://t.co/shAzJn8WSj https://t.co/bXoct0sXd1

2022-06-16 16:55:35 There's only 1 person who fits this profile and he's one of the leading forces in the world for advancing #AI, solving intelligence, and fortunately for us much of that work is in life science, such as #AlphaFold https://t.co/vqUEkGqvzyA conversation with @demishassabis https://t.co/XmvkX8fLA2

2022-06-16 16:33:26 The genetic distance (GD) of #SARSCoV2 variant's receptor binding domain predicts vaccine effectiveness vs symptomatic infections (from ~2 million sequences, 49 studies, >

2022-06-16 02:37:51 RT @demishassabis: Thanks for having me on the podcast @EricTopol, was one of the most fun and wide-ranging conversations I've had, discuss…

2022-06-15 21:28:21 3. 3-shot mRNA vs Omicron hospitalization had 77% (95% CI 71,82%) effectiveness in 21 US hospitals https://t.co/EbI5MRTM1O https://t.co/anG7253CWr

2022-06-15 21:28:19 2. Continued "That previous #SARSCoV2 infection history can imprint such a profound, negative impact on subsequent protective immunity is an unexpected consequence of COVID-19" —@BoytonRosemary @Daltmann10 and colleagues @ScienceMagazine https://t.co/dFtjfp9cGY

2022-06-15 21:28:18 A 3-fer on Omicron infections1. Vaccine protection vs BA.1 and BA.2 variants similar, national Qatar study https://t.co/VVcQuMSNqR @NEJM2. Evidence of imprinting ("antigenic sin") by ancestral or Alpha infections w/ reduced immune response to Omicronhttps://t.co/PE4QjMv69U https://t.co/WVT2M6xKBt

2022-06-15 17:34:25 I’ve done a lot of interviews over the years, but I can’t remember one as enthralling as this one with ⁦@demishassabis⁩ on #AI, #alphafold, foundation models and the future of biomedicine ⁦@DeepMind⁩ w/transcript https://t.co/vqUEkGqvzy

2022-06-14 15:56:02 @FSBuchholzer @KasperKepp @apsmunro Actually, your accusation &

2022-06-13 22:52:54 RT @EricTopol: "We estimated that a single-payer universal healthcare system would have saved 212,000 lives in 2020 alone. We also calculat…

2022-06-13 20:33:08 “But the threat – mostly of long-term problems – seems too big to ignore.”Thanks Bob for this very important thread https://t.co/BkQzKexv5m

2022-06-13 20:14:03 Link to paper https://t.co/eNKJhkt1GX w/ @MeaganCFitz @AlyssaParpia @abhiganit and collaborators

2022-06-13 20:14:02 "We estimated that a single-payer universal healthcare system would have saved 212,000 lives in 2020 alone. We also calculated that US$105.6 billion of medical expenses associated with COVID-19 hospitalization could have been averted by a Medicare for All system."@Alison_Galvani https://t.co/cbE58eBprh

2022-06-13 17:39:27 Dr. Monje's excellent https://t.co/NxZp0l89Bn

2022-06-13 17:37:35 "We explored the neurobiological effects of [mild] respiratory SARS-CoV-2 infection and found white-matter-selective microglial reactivity in mice and humans" Parallels to chemo-brainhttps://t.co/R8LoXsCDcO @michelle_monje @VirusesImmunity @ThisIsAnthonyFC @CellCellPress https://t.co/Fq1QlopJiF

2022-06-13 16:26:26 @euanashley Thanks Euan

2022-06-13 16:22:43 The Peizo1 ion channel protein was found to trigger cardiac hypertrophy, with important potential implications for an unmet clinical needhttps://t.co/0aRm4vGekL@NatureCVR @VictorChangIns @BorisMartinac @justsaysinmice https://t.co/W1IswsfQLI

2022-06-13 15:32:53 @NatureBiotechA rapid (<

2022-06-13 14:40:24 "These kinds of vaccines could buy us long-lasting protection against infections and disease. When combined together, our armamentarium for fighting Covid is growing" On the potential of nasal and pan-β-coronavirus vaccineshttps://t.co/UhoGKQdBFO by @deeptabhattacha @nytopinion

2022-06-13 14:33:15 A cluster of unprecedented reports of individualized medicine for cancer—I've tried to summarize and contextualize here https://t.co/uM9vNK1tF3

2022-06-13 14:03:59 Our covid times by @BruceEricKaplan https://t.co/6iLFDoKcfC

2022-06-12 23:01:00 Our brains get hotter than anticipated: 1st 4-D map of healthy human brain temperature indicates deeper brain regions often exceed 40°C, especially for women during the daytime https://t.co/o0Xdm5f7d9 by @Neurocool and colleagues @MRC_LMB @Brain1878 https://t.co/Sx0d8uvDzo

2022-06-12 22:25:39 Worthwhile insights on this from @karpathy and @cajundiscordian https://t.co/kRzal3bFeJ

2022-06-12 18:29:05 Covid in Colorado https://t.co/wS1wyTXwit

2022-06-12 17:45:37 To contextualize this post, in particular, that has evoked considerable interesthttps://t.co/CPwDqlV2KD

2022-06-12 17:45:36 A Google engineer @cajundiscordian claimed it was and was put on paid administrative leave for violating its confidentiality policy https://t.co/RM1wwUELfN by @nitashatiku with balanced perspective https://t.co/UJHZmbROJL

2022-06-12 17:45:35 We're well into the 3rd "large-scale" era of machine learning https://t.co/0vEjA39edE which has given rise to Foundation Models https://t.co/HK0FYbahd4 and a recent controversy about whether LaMDA, a language model, is sentient #AI https://t.co/KUsH9mc8vX

2022-06-12 16:06:24 @BlocknixBibi You are VERY wrong. The Covid pandemic is not just about deaths. There's this thing called #LongCovid affecting millions, you fail to acknowledge. There are millions of people sick right now, and hundreds of thousands in hospitals around the world for Covid, many in the ICU

2022-06-12 15:39:21 "73 percent of people who die of cancer had cancers that are not detected by standard tests" https://t.co/vwK8yOY7hYCould a new $949 blood test change this?Not yet. I wrote about it here>

2022-06-12 15:12:36 The mysterious acute hepatitis in children is being called Long Covid Liver https://t.co/nuW0jyhQk5

2022-06-11 22:43:39 RT @VirusesImmunity: A brilliant &

2022-06-11 22:34:18 BA.5 is on the rise in Australia, toohttps://t.co/0wnV0URdjp

2022-06-11 22:21:48 RT @DKThomp: “I believe this is the first time this has happened in the history of cancer”https://t.co/gaEMq13lH7Here is the shot of ne…

2022-06-11 22:20:25 RT @PeterHotez: It’s really interesting @EricTopol how the same subvariants are now producing such widely divergent public health effects i…

2022-06-11 19:25:19 @berthacoombs Masks, distancing, ventilated, filtration etc

2022-06-11 18:55:56 Not every day you see 3-year follow-up of one-shot genome editing to keep 31/31 people with severe sickle-cell disease without any crises and 42/44 with beta-thalassemia without transfusionshttps://t.co/QpFJGa1Kxr #EHA2022 @CRISPRTX

2022-06-11 18:27:57 https://t.co/d7VsfmoKYb

2022-06-11 18:27:56 https://t.co/aAhdTjOihA

2022-06-11 18:27:55 Last week BA.4/5 accounted for 13% of new cases in the US (95%CI 9,18%)Note the biologic features of these 2 variants in the posts below https://t.co/90n2CrRkzx

2022-06-11 18:15:27 Not a good idea to capitulate when the #SARSCoV2 variants with the most immune escape since the pandemic began are into exponential growth, especially when there's so much that could be done beyond the usual measureshttps://t.co/N5zk6WaGIt

2022-06-11 18:15:26 US cases are still rising, 7% increase week-to-week, >

2022-06-11 18:00:05 BA.4/5 is on the rise to become dominant in the US and UK. It hit South Africa and Portugal first. Note the difference in impact for those 2 countries in deaths https://t.co/9Y4io9tZwo

2022-06-11 15:36:57 RT @stevenbjohnson: “The narrative has been incubating for many years, but in recent days we are witnessing some extraordinary progress in…

2022-06-11 14:31:37 If you're looking for some very upbeat biomedical stuff, here it ishttps://t.co/uM9vNKj53D…Including the first time immunotherapy alone eliminated the need for chemotherapy, radiation and surgery

2022-06-10 23:20:56 @EagleMD3 Much appreciated

2022-06-10 23:04:56 @cocodoxy Thank you!

2022-06-10 22:49:00 I wrote about a cluster of new individualized medicine reports for cancer that are noteworthyhttps://t.co/uM9vNK1tF3

2022-06-10 16:49:47 Science communication during public health criseshttps://t.co/GxdFO841cI @Clin_Chem_AACC @_AACC w/ @hholdenthorp @apoorva_nyc @jsross119 @dicktofel @ClinChemJoe https://t.co/AQRp5J9qi5

2022-06-10 15:46:49 The Omicron subvariant wave (particularly BA.4/5) is starting to emerge in the UK and the implications are nicely summarized in this https://t.co/Zymh4BqGOK

2022-06-09 23:14:12 In case you are not familiar with the nuclear pore complex, it is in every cell of your body (that has a nucleus), comprised of >

2022-06-09 22:25:42 More NPC stuffhttps://t.co/Cyq6RGfpFfhttps://t.co/JTYzbbvXM9 https://t.co/opADCCIpeO

2022-06-09 22:21:43 At @TheEconomist, a great overview on foundation models, an exciting, rapidly evolving frontier in #AI. Best line:"True, foundation models are capable of behaving like an idiot, but then humans are, too."https://t.co/HK0FYbahd4https://t.co/eqdvWTbdD9 https://t.co/xvMrwX7uuh

2022-06-09 20:33:28 Enough with the mice. We need this for peoplehttps://t.co/1fxeOGzBKdPerformed better than intramuscular shots@PNASNews https://t.co/CyJ4moUxRx

2022-06-09 18:49:31 Extraordinary work and perseverance by multiple groupshttps://t.co/rzi5w0CcbFThis wouldn't have happened without #AI #AlphaFold https://t.co/Gq8supfKRv

2022-06-09 18:33:39 Today is a BFD triumph in life science—solving the 3D structure at near atomic level resolution, one of the world's hardest, giant jigsaw puzzles—the nuclear pore complex—the largest molecular machine in human cells, with structure-based AI prediction @ScienceMagazine https://t.co/k2B91KOr8B

2022-06-09 16:01:53 We've chronically undervalued the importance of diet for promoting &

2022-06-09 15:34:43 With all we've learned in recent years about the gut #microbiome, what is healthy eating now?https://t.co/ashCdpiVzp A tour de force review @cellhostmicrobe https://t.co/beTCzbUj2P

2022-06-09 15:24:43 The BA.4/5 variants, the next chapter of the pandemic in the US and Europe, is a story of immune escape, nicely characterized in this new @CellCellPress paperhttps://t.co/1aCfzw6ivO https://t.co/mhA87niphU

2022-06-09 13:33:50 Nationwide England data (57 million people) for the 1st 2 waves of the pandemic and the risk of immune-mediated diseases/medications used to treathttps://t.co/8slzQXGuHm @LancetDigitalH https://t.co/AJ4rLMOpaL @TheLancetRheum https://t.co/1ECfsRHGYz

2022-06-09 12:40:11 Ahem. Over 210,000 confirmed new cases yesterday (= well over a million real ones) https://t.co/krzSvEkEI2

2022-06-09 01:37:31 If you prefer event curves https://t.co/BKaeneXmnU

2022-06-09 01:37:30 New @NatureMedicineGood to see @KPSCalResearch, large health systemOmicron BA.1, BA.1.1, BA.2 infections had far less unfavorable outcomes than Delta, *adjusted*, ~40% less hospitalization, ~80% less death (vaxx or no vaxx)https://t.co/dYwYnzTu0r https://t.co/T0snElzTxO

2022-06-08 23:31:42 The march of the Omicron subvariants will prolong the current wave, which is the highest case burden except during Omicron BA.1 in the US pandemic, adjusted for lack of central/PCR testing https://t.co/oeV2d8JkIL

2022-06-08 23:18:38 A simplified mutation map of the changes in the spike protein for the US Omicron subvariant wave https://t.co/JlIP7KuUFf

2022-06-08 22:47:35 Omicron subvariants response to monoclonal antibodies: more immune escapeTable (lower number, more sensitivity) vs BA.2BA.4/5: ~20-fold more resistant to Evusheld(on path to US dominant)BA.2.12.1: 4-fold more resistant (now dominant in US)https://t.co/cULie0sU8H https://t.co/4EmKghcz7l

2022-06-08 21:04:40 "Our results underscore the potential importance of selective pressures such as the use of monoclonal antibodies — in combination with the lack of an effective endogenous immune response--in promoting escape mutations"https://t.co/Gtzmv6y3AN in 5 immunocompromised patients @NEJM https://t.co/veGpi3Vhhr

2022-06-08 18:10:03 They're still increasing during the current US Omicron subvariant wave, but at least the rate of rise is slowing@OurWorldInData https://t.co/HrYFvqV25B

2022-06-08 17:43:26 Challenging dogma:When mutations don't change the amino acid (synonymous) but alter the fitness of the protein, and can be as harmful as non-synonymous mutationshttps://t.co/zEQahjDhw0https://t.co/WUUNNgVB7E@Nature @NatureNV https://t.co/FuTMt9ChWH

2022-06-08 17:29:02 An exceptional #LongCovid thread by @trishgreenhalgh https://t.co/w1o2qNfJoa

2022-06-08 15:56:12 When #CovidisAirborne at a Nurses Station during a hospital outbreakhttps://t.co/2MEqNA6ZlU @JAMANetworkOpen https://t.co/8ycndJ08PL

2022-06-08 15:33:24 More evidence of #SARSCoV2 viral reservoir in some patients with #LongCovid "the presence of residual virus within the appendix and breast tissue of 2 patients who exhibited LC symptoms"https://t.co/bc36mOGyxd https://t.co/V4nC8NzqEM

2022-06-08 15:13:40 And the 1st onehttps://t.co/TKtZSpSuef

2022-06-08 04:00:31 @GetOffMyLawnPod That there's potential that Paxlovid might not work very well in the future

2022-06-08 03:45:43 High level Paxlovid resistance (up to 80-fold) can be created in lab w/ highfitness2 reports replicate (mutations L50F, E166V/A, +/- L167F)https://t.co/EoLVXLRcKhhttps://t.co/FTyE4RP8yRSupports need for genomic surveillance + development of more potent oral anti-viral pills https://t.co/s3Azsw97Tb

2022-06-08 01:15:01 more Covid in Florida https://t.co/1rYT5tf2XW

2022-06-07 23:03:11 Reduction of severe Covid increased when Evusheld given early, and present/similar magnitude across nearly all subgroups https://t.co/MbtUtdXhTq

2022-06-07 22:56:27 @LancetRespirMed A randomized trial of Evusheld vs placebo reduced severe Covid, from 9% to 4%, among 910 participants (RRR 50.5%). Previously Evusheld had proven efficacy for prevention in immunocompromised

2022-06-07 21:26:23 Covid in Florida https://t.co/bVTQ2CQmW6

2022-06-07 21:07:01 @JeffBlackham @FryRsquared Agree!Important data point @FryRsquared reviewed for chemotherapy after breast cancer surgery in 100 women. How many does it actually benefit? 5 https://t.co/IcsLqVxwVt

2022-06-07 19:52:36 As predicted, FDA Advisory Committee votes 21-0 today to recommend @Novavax EUA

2022-06-07 19:33:32 RT @virusninja: This study is one of the few that benchmarks the host response to #SARSCoV2 against #flu. This enables us to define what m…

2022-06-07 18:51:25 That's right.https://t.co/OUwlOKLlkq by @henryimiller @GeneticLiteracy

2022-06-07 18:27:24 Not every day there's an anti-obesity drug that leads to 15-20% body weight loss https://t.co/5jiUjsV5nB recently @US_FDA approved for #diabetes treatmenthttps://t.co/o3gMtSrkeG https://t.co/bWpb9BA5TJ

2022-06-07 17:36:21 "A once-in decades opportunity now exists"New @JAMA_current accompanying the @CDCgov reporthttps://t.co/vuF9Y0FFhn via @chrishendel https://t.co/4nJmrjNx65

2022-06-07 17:01:39 "Ventilation is a key strategy recommended to reduce COVID-19 spread in school settings" —new @CDCMMWR reportSo why aren't we doing that everywhere?https://t.co/mkhKpV9PGL #COVIDisAirborne https://t.co/vA150WKy0n

2022-06-07 16:59:45 @EcoSexuality Hopefully, if the L452 mutation is key, and shared by these 3 variants (BA.2.12.1, BA.4, BA.5)

2022-06-07 16:09:57 Olfactory bulb (comparison with influenza) and transcriptomics of peripheral organs https://t.co/vFWJeTYE9M

2022-06-07 15:44:23 New, important #LongCovid report @ScienceTM: persistent pro-inflammatory biology"These data highlight a molecular mechanism for persistent COVID-19 symptomatology and provide a small animal model to explore future therapeutics."https://t.co/iLQ8dTw8BA @Justin_Frere @virusninja https://t.co/sheH9B5W4v

2022-06-07 15:12:07 "So drink up--but it would be prudent to avoid too many caramel macchiatos while more evidence brews." Excellent editorial succinctly reviews all the data on coffee and outcomes, by @wee_christina https://t.co/olLFERsRmN https://t.co/RE8R9RDjGt

2022-06-07 15:03:17 The @AnnalsofIM studyhttps://t.co/NmTg0F3xzu https://t.co/jiqV3fQ3H4

2022-06-07 15:03:16 For lovers, good news (with the usual caveats of observational studies, as highlighted below)https://t.co/eCK4bzwuo2 https://t.co/8gI2nXn8Py

2022-06-07 14:48:38 ->

2022-06-07 00:15:11 Mass shootings in the US—2022, thru June 5, 246—2021 year, 240https://t.co/DcI1cKrbeT@juledurg @dataKateR https://t.co/C2A031RGhS

2022-06-06 23:40:43 @CarlosdelRio7 @AnnalsofIM Many were not

2022-06-06 21:35:18 RT @JamesSurowiecki: "But, of course, CDC can't provide the data" is such a sad, and true, sentence.

2022-06-06 21:33:03 When the primary efficacy metric is low, you go on a hunt for more:"This secondary analysis of the ... trial sought to identify other potential clinical benefits of molnupiravir versus placebo@AnnalsofIM 1° results https://t.co/MC2XwTek8V2° resultshttps://t.co/NNTfy1H5QZ https://t.co/ezTnbNVa7k

2022-06-06 20:25:30 A look at who is getting hospitalized in the US during the BA.2/BA.2.12.1 wave.>

2022-06-06 19:59:32 Maternal asthma and the risk of children with asthmaEvidence for an epigenetically mediated mechanism during in utero exposure https://t.co/OgVfgEjJyN @PNASNews https://t.co/UFGjIzl7pQ

2022-06-06 18:00:02 BA.4 and BA.5 have different mutations than BA.2.12.1 in the spike protein and other parts of the virus (nucleocapsid, ORFs) as shown herehttps://t.co/0dcenIjbZ6 https://t.co/cKewJ8ADrw

2022-06-06 16:16:50 Typo: BA.4/BA.5 more immune evasiveness than BA.2.12.1.....

2022-06-06 16:13:03 The graph at the left is weeks behind. On the right, from Minnesota's twin cities, is where we are headed. BA.4/BA.5 has more immune evasiveness than BA.1.12.1, more transmissibility, and more pathogenic in the lab and experimental model https://t.co/x2K0UT1Tqg https://t.co/JhD6Fhbhe8

2022-06-06 14:45:43 4th shot datahttps://t.co/W4xkPskVdP

2022-06-06 14:40:55 @RyanCartwright @joshulick yes

2022-06-06 14:34:15 Following one of the worst 1st booster shot uptakes in the world among developed countries, of more than 112 million Americans age 50+, only ~5 million have had a 2nd booster shothttps://t.co/9u80GJOkQl by @joshulick https://t.co/hyDGbbBMDc

2022-06-06 14:21:11 "The coronavirus pandemic has created a mass-disabling event" #LongCovid https://t.co/0urhgtH3zZby @FrancesSSellers

2022-06-06 01:09:20 RT @macroliter: @EricTopol @LizSzabo Yup. I’m quite concerned that 3x mRNA vaccinated folks like me who’ve thus far managed to avoid contra…

2022-06-05 17:51:53 'A complete remission in every single patient is “unheard-of”'Combining genomics diagnosis of mismatch repair deficient + PD-1 immunotherapy led to complete remission of 18 consecutive patients w/ advanced colorectal cancer https://t.co/54yFGoTDoZhttps://t.co/CZsoFHM0Gl #ASCO22 https://t.co/Lqtlir8Nr3

2022-06-05 16:56:49 @moskov Because the have the same spike sequenceThey differ in other parts of the virus https://t.co/92rCNiT9f2

2022-06-05 16:26:55 It's not over, by any means, but the chances of dying from Covid keep declining https://t.co/6Bl6ULPeey

2022-06-05 15:58:18 In case you were wondering if BA.4/5 will outcompete BA.2.12.1, and more.... https://t.co/7Lv7kAyD3j

2022-06-04 16:04:05 6 cases of myocarditis, all recovered, no other safety concernsData clearly meet criteria for EUA and many people have been waiting for a non-mRNA alternative for primary vax or booster https://t.co/tYCbGgCjv1

2022-06-04 16:04:03 The @Novavax vaccine @US_FDA documentshttps://t.co/QZHMRa0N9eGood efficacy (pre-Omicron) vs all infections https://t.co/pzrNwjCRBa

2022-06-04 15:36:13 A distinct post-Covid phenotype with smell and taste dysfunction is associated with better recovery #LongCovid "This stresses the heterogeneity of post-acute Covid sequelae, each requiring tailored management strategies"https://t.co/nTfTMjTjui https://t.co/fz8xaR80te

2022-06-04 15:11:07 A randomized trial in patients with colon cancer demonstrates the benefit of liquid biopsy to markedly reduce chemotherapyWhen "biology outperforms anatomy to improve therapy"https://t.co/gd0vVevqJX #ASCO22https://t.co/D7M1osPXWw https://t.co/6xNTDhuYB1

2022-06-04 14:56:42 The "S" word for the pandemic is subvariants. Who even heard or used this word prior to Omicron's descendants? 6 weeks ago the US was in the best shape since it all started. Then came BA.2, now BA.2.12.1, and next up BA.4, BA.5. https://t.co/CwdlEZMdWJ

2022-06-03 19:18:29 @larrybrilliant Thanks Larry. Wish it could be more optimistic

2022-06-03 17:59:53 Our immune system follows circadian rhythm. A new review @SciImmunology. And why getting Covid vaccines in the morning elicits a better antibody and cellular immune responsehttps://t.co/nqDxy3XYv1 @ScheiermannLab https://t.co/qfmkX4kQ4g

2022-06-03 17:31:43 Confirms and extends prior summaryhttps://t.co/d7VsfmoKYb

2022-06-03 17:01:05 New @CDCMMWR on #Monkeypoxhttps://t.co/h9lI3IHt2o https://t.co/aecCLiOHJ2

2022-06-03 15:56:32 Just out @SciImmunology Post-vaccination breakthrough infections with Omicron BA.1 provide strong neutralizing activity vs BA.2 (and prior variants) but not vs BA.4/5https://t.co/EyBy7aaEps https://t.co/RYhIAwUHj5

2022-06-03 14:51:58 From my book Deep Medicine https://t.co/GLk8mic7LH

2022-06-03 14:43:52 Human touch is irreplaceable. https://t.co/yarGl5vo2K

2022-06-03 14:27:52 A 59 % higher risk of developing diabetes in post-acute COVID-19 phase versus healthy controls, from pooled analysis from 4 large retrospective studies #LongCovidhttps://t.co/l0MtYPgbRO https://t.co/fcqNQUuA9b

2022-06-03 04:37:31 7% reduction in cases, week-to-week https://t.co/QPRo6jaOkaI'm certainly not convinced it's peaked, but I never give up hope. And know there will likely be BA.4/5 to contend with and known unknown variants ahead. https://t.co/mhAD8MbYOL

2022-06-03 04:04:39 Could the US BA.2/BA2.12.1 wave have peaked?Hard to know with under-reporting/lack of testing and many regions still in flux, but let's hope it's a good sign https://t.co/PA3FpMKeSI

2022-06-02 23:33:35 On a related front, Turbocharging the T cells to fight cancer https://t.co/2Gsq6B27jQ https://t.co/CvJBSiFG4u

2022-06-02 18:57:05 "Height may be an unrecognized but biologically plausible risk factor for several common conditions in adults" @PLOSGenetics https://t.co/c0rmnf91RMTall stature associated w/ protection vs atrial fibrillation, cardiovascular conditions but heightened risk (no pun) for others https://t.co/JtaTAQIvj0

2022-06-02 18:01:58 Nothing to see or do anything about hereBecause we've capitulatedhttps://t.co/N5zk6WaGIt https://t.co/feorbboflJ https://t.co/6DiTkGYpvG

2022-06-02 17:58:11 With the US now BA.2.12.1 variant dominant, yesterday there were over 263,000 new confirmed cases reported and 1,247 more people hospitalized for Covidhttps://t.co/QPRo6jaOka

2022-06-02 17:40:50 This may be the 1st report of the liquid biopsy biomarker result predicting immunotherapy response better than a solid (tumor) biopsyhttps://t.co/CahP0OUYDI #cancer @TischCancer @MountSinaiNYC @ChristianRolfo https://t.co/CWxpBKmkRK

2022-06-02 16:53:01 What was the impact of Covid vaccine mandates for increased uptake across multiple countries?A big range, from <

2022-06-02 16:45:28 Correction: autoimmune diseases (IBD, MS, SLE, RA, PSS, etc) and heart disease

2022-06-02 16:41:19 You'll be seeing a lot more of these headlines, not just for infectious diseases, but also for cancer, autoimmune heart disease, and genetic disordershttps://t.co/SDfsw4g30KMy substack review of this exciting path forwardhttps://t.co/KoEDkEsYrb https://t.co/nTmcL5T2DH

2022-06-02 01:19:20 Even with the common rebound issue, it really turned out to be a just-in-time breakthrough, as I wrote about ~6 months agohttps://t.co/lcAtZU4RJW

2022-06-01 22:25:17 More symptoms, disruption with BA.2 than BA.1https://t.co/eTDXmumK7wReinforces: as the virus evolve, it doesn't necessarily become less virulent

2022-06-01 22:25:16 Recently, worse symptoms from BA.2 infections have been documented compared with BA.1below. A new report shows the BA.2 variant replicates more efficiently in the upper airway and lung compared with BA.1https://t.co/GQdm0hJ65w @hkumed https://t.co/g6DzDe0hta

2022-06-01 22:07:58 Accompanying editorial. helpful context, significancehttps://t.co/3JUN43GH8h by @CMelief https://t.co/N5Z6bOIUIp

2022-06-01 21:04:30 It's a @NEJM case report, but a groundbreaking one. For a woman with refractory pancreatic cancer, genetically engineered T cells directed towards the KRAS driver mutation achieved substantial tumor regressionhttps://t.co/X7NuoRehtq https://t.co/TsGg84GzHa

2022-06-01 20:00:44 A new real-world effectiveness report of Paxlovid during the Omicron wave: in people age 65+ an 81% reduction in death and 67% reduction in hospitalizationshttps://t.co/ZNohKWmTK6@ArbelRonen @ClalitHealth and colleagues https://t.co/MbakbgkbAJ

2022-06-01 18:14:59 The overall sensitivity of Covid detection by trained dogs was 97% and "even reached 100% in asymptomatic individuals" compared to nasopharyngeal swab PCR tests. Overall canine sensitivity vs PCR (97% CI: 91 to 99 versus 84% CI: 74 to 90, p = 0.006), https://t.co/tE2oD6Ecdf https://t.co/uC9hDTH9WM

2022-06-01 17:16:25 The mutations our blood cells acquire as we age—clonal hematopoiesis—is the norm, 10% of blood cells for age 70+, with marked reduction of diversity

2022-06-01 14:41:31 A1 and other useful graphs, data https://t.co/AXEknMTPZs

2022-06-01 14:41:29 Yes, the marked increase in transmissibility of Omicron over Delta was a driving factor. But vaccinations in age 65+ during Omicron were critical: 2-shots reduced deaths by 85% and with a booster there were 96% less deaths https://t.co/8jL05VYudb

2022-06-01 13:52:14 Our brain's impressive immune defense systemhttps://t.co/RSNmd230Xm@Nature feature by @DianaMKwon https://t.co/FYGBuOFM0c

2022-06-01 13:47:33 A black market for Covid anti-viral pills, the Molnupiravir experience https://t.co/zzCOKZnf2u @bmj_latest https://t.co/IT6FuMy1rM

2022-06-01 02:37:53 A new @bmj_latest systematic review of 53 studies of boosters and mix and match shows marked benefit of boosters but little difference for mixing (mRNA and adenovirus) vs matching (3 mRNAs)https://t.co/QsoBUwyIhx https://t.co/euWoXj3ul8

2022-06-01 02:03:27 And is dominant (>

2022-06-01 02:03:26 The BA.2.12.1 variant is now 59% [95% CI 55,63%] of new cases in the United Stateshttps://t.co/jjl2AnwOWX(It's ~25% more transmissible than BA.2, which it out-competed) https://t.co/S6Uo7GscDh

2022-06-01 01:53:57 Publsihed today @PNASNews Mask wearing significantly reduces #SARSCoV2 community transmission. Analysis of the effect in 92 regions, 6 continents https://t.co/t9lD0KYvTt by @g_leech_ and colleagues https://t.co/I6HxL5fSR0

2022-05-31 22:31:01 Is it time to do systematic medical real-world reviews with #AI support to promote accuracy and reduce bias?https://t.co/Mua9o8tspe@AnnalsofIM @AnnelieseArno @jhjelliott https://t.co/gQE4vkhnIL

2022-05-31 18:52:33 Quite a feat:"We report the transplantation of a human liver discarded by all centers, which could be preserved for several days using ex situ normothermic machine perfusion."https://t.co/TQuXIh0ie3@NatureBiotech

2022-05-31 16:59:18 "As of mid-May, more than one-quarter of Americans 65 and older had not had their most recent vaccine dose within a year. And more than half of people in that age group had not been given a shot in the last six months." https://t.co/s2iDznH0x8

2022-05-31 16:27:43 Omicron's lethality rate among seniors was worse than Deltahttps://t.co/DqZooPJKvaThe waning of vaccinations, lack of adequate booster uptake in this high-risk age group were contributory factors

2022-05-31 16:17:14 @CT_Bergstrom @JAMANetworkOpen In agreement. Here are the other graphs from their report. The other issue is pitting models vs doctors when that is not the real world for how medical decisions/prognosis are determined https://t.co/kg8TpWXeOU

2022-05-31 15:34:23 When the machines outperformed 74 oncologists for predicting outcomes in a prospective study of over 2,000 patients with advanced cancer #AIhttps://t.co/UmfjRhZak2 @JAMANetworkOpen https://t.co/5zJSb0qv0g

2022-05-31 15:23:18 "Our findings suggest that even in the context of airborne transmission, approximately 4% of index [Covid] cases in indoor settings would account for 80% of secondary cases"A new analysis of superspreader events and overdispersionhttps://t.co/OsTuZfJHPU

2022-05-31 15:12:13 Pulse oximetry overestimates arterial oxygen saturation in racial minority groups with Covid, leading to lack or delay of therapies. This "occult hypoxemia" may worsen outcomeshttps://t.co/fc9FRQUx1k @JAMAInternalMed https://t.co/QzKwVGwZjh

2022-05-31 14:03:27 Over 2 billion doses of mRNA + nanoparticles has laid the foundation for a new approach to infectious and autoimmune diseases, cancer, genetic disorders, and prevention of heart attackshttps://t.co/KoEDkEsYrb

2022-05-31 02:44:18 Progressively taking the death out of the Covid calculus, now 90% reduced from peak worldwide@OurWorldInData https://t.co/GNBRK6gMyC

2022-05-31 01:05:13 Quite the lede"The isolation of CCoV-HuPn-2018 from a child respiratory swab indicates that more coronaviruses are spilling over to humans than previously appreciated."https://t.co/GmUA4P289i @CellCellPress by @veeslerlab https://t.co/RqZd6e9NL4

2022-05-31 00:39:23 RT @gabrieldane: Happening tomorrow, 7p ET. Let’s BLOW THIS UP #medtwitter. Let’s show we can focus our collective energy on making a dent…

2022-05-30 21:36:13 A look at the bright side of the pandemic for decades to comehttps://t.co/KoEDkEsYrb

2022-05-30 17:34:19 "Our study reveals how specific neuron clusters located in diverse regions of the brain relevant to fear and the fight or flight response cause massive changes in leukocyte distribution and function"Elegant work w/ #optogenetics @WolframPoller @IcahnMountSinai @SinaiHeartBlood

2022-05-30 17:27:54 With a great resource that summarizes all the mutations that have changed amino acids and led to impact, with references https://t.co/5WtVC43zvz

2022-05-30 17:15:21 @NatureMedicine "The pandemic is not over, and #SARSCoV2 is spreading at a high level globally. Now is the time to enhance global sequencing capacities, focusing on widening coverage to include previous geographical and population blind spots"https://t.co/yL2xisDH0r@lsubissi https://t.co/xip3MR762v

2022-05-30 16:22:17 Just published @Nature How acute stress impairs our immunity to Covidhttps://t.co/dmI0FgzoOV https://t.co/ru5xh26Yjb

2022-05-30 15:51:29 Covers @NewYorker by Eric Drookerpaired withhttps://t.co/z04JguVmPL by @jelani9 https://t.co/zlwl0Q1CZ9 by @rachmonroe https://t.co/N74IKbf1ZO by @winterjessica https://t.co/l2yXqQdHXx by @JohnCassidy https://t.co/uUGMGn3nAa

2022-05-30 15:33:02 RT @ChasBeekeeper: @EricTopol @AditGinde That’s reassuring and I’m so grateful for having received Evusheld in February. Without additional…

2022-05-30 15:25:37 For the pandemic, "U.S. deaths were 15 percent above normal — a number surpassed by only four other large countries in the same income group: Chile, the Czech Republic, Poland and Romania."https://t.co/mRvXoGktRd @DeniseDSLu @nytgraphics https://t.co/rShmir7w0g

2022-05-30 15:11:09 Paxlovid became a household name in the US during the BA.2 waveDuring the week that ended May 6, prescribers wrote 8,977 scripts of Lagevrio (Molnupiravar) and 118,123 scripts of Paxlovidhttps://t.co/bkCwy9p6kL by @JaredSHopkins

2022-05-30 15:05:41 A bad case :-)by @speedbumpcomic https://t.co/FzkBfRump5

2022-05-30 01:41:34 RT @Bob_Wachter: We’ve been counting on Evusheld to remain a key tool for protecting immunosuppressed people during Omicron. Ir wasn’t a sl…

2022-05-29 21:40:28 First real-world assessment of Evusheld protection for immunompromised people during the Omicron wave:Marked reduction of mortality, hospitalization and infectionshttps://t.co/q59gyiInui @AditGinde https://t.co/zvpGL97JOX

2022-05-29 18:39:28 If you're looking for some inspiration, look no further than @jacindaardern's commencement addresshttps://t.co/I8GJCklHKx)

2022-05-29 17:50:07 https://t.co/9BEj4Ns973

2022-05-29 17:38:54 RT @ACPinternists: How can we address #priorauth and the burden it puts on physicians/patients? On 5/31, join ACP &

2022-05-29 17:32:00 Graph via @trvrb https://t.co/1Fc9uytdv4 https://t.co/L6YKTLHPok

2022-05-29 17:31:59 Updating, one year laterOriginal: https://t.co/xec3OdHiFV @CellCellPress by @K_G_Andersen and colleagues https://t.co/8Kt6rDfx7E

2022-05-29 15:23:36 "compel us to take bold action" --@aboutKPSay it: Ban assault weapons. And much more https://t.co/OF43dV9NvO

2022-05-29 15:18:05 "We could have more Warp Speeds — for therapeutics, for ventilation systems, for rapid global provision of vaccine technology."https://t.co/v54dznAqUF by @dwallacewells @nytopinion https://t.co/KxlIHrmYtZ

2022-05-29 15:10:06 That's right. Thanks @aboutKP https://t.co/JEUyY3jd8q

2022-05-29 02:02:01 I attempted to make a graph to highlight this point of *intrinsic* virulence increasing up to 3 times via diff't (sub)variants during the pandemic, which has been misinterpreted. The point is made below w/data above and the graph has been deleted. https://t.co/eZmw5hAVOa

2022-05-29 01:40:38 @socalsysbio There is confounding of vaccination and prior infection. Adjusting for that, Omicron was thought to be ~25% less virulent than Delta. Subsequent studies for BA.2 and BA.4/5 are summarized in the

2022-05-28 22:41:54 The progression of the virus's fitness throughout the pandemic. Fitness encompasses a lineage's growth, Ro reproduction number, immune-evasiveness and generation time. Graph doesn't include BA.2.12.1 and BA.4/5 which are more fit than BA.2https://t.co/0WY7gW3RtB https://t.co/gKvvyYbMOO

2022-05-28 22:14:04 The US current BA.2/BA.2.12.1 wave may be extended by the BA.4/5 variants, owing to their growth advantage and higher fitness, as aptly reviewed here https://t.co/1Fc9uytdv4

2022-05-28 20:14:35 "Odds of infection for those who did not always compared to those who always wore a mask was 66% higher pre-Delta, 53% higher during Delta, declining to 16% higher during Omicron"https://t.co/mXBde7wn6AOmicron's hyper-transmissibility necessitates high- quality masks (KN95/N95) https://t.co/CEtUmz5lXM

2022-05-28 16:49:44 Two countries where the BA.4/BA.5 variants became dominant: the outcomes are quite different@OurWorldInData (Not so easy to extrapolate impact of variants across places w/ marked differences in population demographics, prior/strain of infections, vaccinations, testing, etc) https://t.co/tgfHVsR3qY

2022-05-28 16:26:53 The current BA.2/BA2.12.1 wave is the 2nd highest case burden for the US pandemic

2022-05-28 16:17:41 The immune response induced by Omicron post-vaccination breakthrough infections is blunted compared with Delta breakthrough infections https://t.co/Bf5oDUKWvh @ImmunityCP @MariosKoutsakos @TheDohertyInst @ProfStephenKent and colleagues https://t.co/yWvbd4u3oY

2022-05-28 15:57:39 Prior Covid, unvaccinated, offers limited protection from Omicron infections in contrast with 3-dose vaccination: new report from the California prison system during Omicron wave of ~25,000 cases and >

2022-05-27 20:27:04 "BA.4 and BA.2.12.1 can overcome immunity provided by earlier infections with other Omicron subvariants." "This was unexpected...maybe we should adapt the system of naming"—@houzhouhttps://t.co/D0Ce1VPmsj @Nature by @amymaxmen

2022-05-27 19:56:34 @trvrb @LongDesertTrain @calmarten I provided the source in the threadhttps://t.co/IKqSKtzdR6 which did include the antigenic map below, conveying the same point as the genetic distance, but may be more difficult to interpret for people not familiar with the mutations https://t.co/IgS0piAXdr

2022-05-27 17:56:42 —BA.2 more symptoms than BA.1 https://t.co/eTDXmumK7w—BA.2.12.1 and BA.4/5 more replication in lung cells than BA.2—BA.4/5 more pathogenic than BA.2 in exp'tl modelhttps://t.co/TvwlO8ljPJ—BA.4/5 more immune escape than BA.2.12.1https://t.co/IKqSKtzdR6

2022-05-27 17:27:20 Keep your eyes on theevolutionThe antigenic distance (how our immune system "sees" the virus) from Omicron BA.1 to BA.2.12.1 (the dominant variant is the US now) and to BA.4/5 is pronounced. Note no functional sub-variants of any prior Greek letter VoCs https://t.co/Q2BTBI2OUJ

2022-05-27 17:00:15 + ThisFederal assault gun ban expired in 2004#ThisIsOurLane @ThisIsOurLane https://t.co/yl5qbH49bx

2022-05-27 15:15:20 https://t.co/GMsglbBvqW

2022-05-27 14:40:04 Or this https://t.co/o3HqIBGndQ

2022-05-27 14:06:35 @mroliverbarnes @FT Thanks for your indefatigable work covering the pandemic!

2022-05-27 13:32:29 .@HHMINEWS https://t.co/VpYawj2qe3 by @laurenmlumpkin https://t.co/LgbZh3kTtt

2022-05-27 13:24:35 And this https://t.co/YKheISjYVe

2022-05-27 13:24:34 This https://t.co/gLd1tQ7raq

2022-05-27 12:51:57 RT @trishgreenhalgh: This is causing waves among virology Twitter. Bottom line: the pandemic is not over, and it's NOT getting milder.

2022-05-27 12:42:09 RT @Noahpinion: Yes we are

2022-05-27 03:55:04 "The United States has 46 percent of the world’s civilian-owned guns "https://t.co/Hf7fTQoRS3That was as of 2018, and has increased since then

2022-05-27 03:50:47 Confirmed Covid deaths, as of todayUS 1,004,121World 6,284,446https://t.co/gV8kcaeLPK

2022-05-27 03:27:30 American exceptionalismThe United States comprises 4% of the world's population 16% of the world's Covid confirmed deaths 40% of world's guns Only industrialized nation in the world with states making abortion illegal

2022-05-27 02:38:45 @TenTenbrink Thank you!

2022-05-27 02:36:05 Table of the 7 casesThe Omicron high viral load issue, as opposed to Delta when the Paxlovid randomized trials were conducted, may well be the driver of this rebound https://t.co/QGWCtff3sy

2022-05-27 02:33:01 @violetblue Thanks, Violet. I had missed this, completely unacceptable and fulfills your WTF label

2022-05-27 02:29:37 RT @gmleunghku: Thanks @EricTopol for shoutout…I’ve put together a thread here to explain in a little more detail about this and another re…

2022-05-27 02:27:42 Paxlovid relapse insights from 7 individualsHigh viral loads at enrollment and for 17 days

2022-05-27 02:01:54 1st report of real-world effectiveness of Paxlovid in the outpatient setting, BA.2 wave, Hong Kong75% reduced death, 31% reduced hospitalization, 53% reduced adverse outcomesNo impact of vaccination on outcomes

2022-05-26 23:33:48 @antoniottwalter @SystemsVirology More than prevalent. BA.2.12.1 is dominant in the US

2022-05-26 23:26:16 Above is the 2nd example of a new variant (BA.2) being more virulent than a predecessor (BA.1)The first was Delta over AlphaNew data today suggests the Omicron subvariants (BA.4/5, BA.2.12.1) may have more virulence than BA.2

2022-05-26 23:20:02 BA.2.12.1 and BA.4/BA.5 characterized in human lung cells and an experimental model by @SystemsVirology —All 3 Omicron subvariants have enhanced replication in lung cells compared w/ BA.2—BA.4/5 is more pathogenic than BA.2 in animal modelhttps://t.co/TvwlO8ljPJ https://t.co/gSwzPoatg3

2022-05-26 23:09:37 The immune evasion is more extensive for BA.4/5 than BA.2.12.1 variant, raising the possibility that the former can out-compete the latter. Only one clinically available monoclonal antibody (bebtelovimab) has full potency against these Omicron subvariantshttps://t.co/IKqSKtzdR6 https://t.co/6RWSGiGtjw

2022-05-26 19:55:14 @hholdenthorp @juliettekayyem @meghas I could have highlighted every word.Thanks Holden https://t.co/rccOheCQeB

2022-05-26 18:10:35 A smorgasbord of outstanding reviews and perspectives on the human microbiome in the new issue of @ScienceMagazinehttps://t.co/Y67TpxzTm5 https://t.co/79q041Tcfz

2022-05-26 18:06:35 The first dissolving pacemaker with a wireless body network for smartphone physiologic vital sign monitoring and real-time patient haptic feedback, on a temporary basis@ScienceMagazine https://t.co/nWtVpvIhyehttps://t.co/ZIzgQkT3Do https://t.co/9FhHSc0LWq

2022-05-26 14:38:22 Head-to-head comparison of immune response, both antibody and cellular, for 4 vaccines: Moderna, Pfizer, Novavax and J&

2022-05-26 14:03:55 "Affinity Escape"Another potential mechanism for #SARSCoV2 immune escape: if a variant has stronger binding to ACE2, it could compete with neutralizing antibodieshttps://t.co/O9ThYVDjWC

2022-05-26 13:47:41 @CarlosdelRio7 @NatureMedicine @zalaly @BCBowe @Biostayan @WUSTLmed Unclear, but certainly worth finding out if it helps

2022-05-26 13:28:45 https://t.co/Lw5joeipRK

2022-05-26 13:17:31 @ZekeJMiller @ashishkjha https://t.co/QPRo6jaOka https://t.co/eIHYp0P8vl

2022-05-26 12:46:33 @ZekeJMiller @ashishkjha Deaths are rising.

2022-05-26 03:14:04 RT @kaitlancollins: Amerie Jo Garza's father, a med aide, says he found out she was one of the victims when he arrived on the scene and was…

2022-05-26 02:10:25 "Only" >

2022-05-25 23:40:14 The J&

2022-05-25 23:36:49 "BA.4/BA.5 are antigenically distinct from previous Omicron variants, particularly BA.1, and are still at a substantial distance from the closely related BA.2."Breakthrough infections help ->

2022-05-25 21:41:41 OWS 2.0 hasn't happened because "we" gave up, very tired, and pretending this is over—when it isn't. Far from it. https://t.co/N5zk6WsPWB

2022-05-25 21:00:26 During the Delta wave in Israel, the importance of hybrid immunity, a booster shot, or prior Covid for protection from infections. In @NEJM today https://t.co/tDjnmxsnSr@MiloLabWIS @WeizmannScience @TechnionLive @IsraelMOH https://t.co/NxFiLtqP29

2022-05-25 18:48:36 @LSteelback @ScienceTM Thanks for your vote of confidence. We have. All these agencies and the @WHCOVIDResponse want to support but there's this entity called Congress that is blocking it = zero funding

2022-05-25 18:32:05 Operation Warp Speed (OWS)1.0 was one of the most important, life-saving programs in US historyAre we foolish enough not to have an OWS 2.0 to get nasal vaccines, pan-sarbecovirus vaccines, and more/better drugs across the goal line?

2022-05-25 18:27:06 Just about every week there is a new, broad neutralizing antibody (bnAb) discovery, like this one, that is variant-proof and would take down all #SARSCoV2, that vaccines could be made to induce, that we're not advancinghttps://t.co/ektcfd0NEN @ScienceTM https://t.co/01xhPBANj2

2022-05-25 17:19:56 RT @chrischirp: This is a really important paper because it looks at risk of long covid and other post covid impacts (eg on kidneys, heart…

2022-05-25 15:55:56 This graph breaks down the risk of BTI by out-patient or hospitalized/ICU. For the common, non-severe breakthrough infections, the risks are still increased during 6-month follow-up for multiple outcomes https://t.co/rEUNf0GBQ8

2022-05-25 15:00:25 Less risk of #LongCovid sequelae with BTI compared with unvaccinated Covid https://t.co/HcygHmYnRF

2022-05-25 15:00:24 BTI relative risk and absolute excess burden at 6 months for death, particularly increased for clot-related, lung sequelae https://t.co/em3KgnPxoM

2022-05-25 15:00:22 Just out @NatureMedicine The natural history of post-vaccine breakthrough infections (BTI) in 33,000 people, >

2022-05-25 14:21:15 freja kirsebom chrischirp he misclassification explanation for these differences in vs hospitalization seems optimistic without clear data to back it up

2022-05-25 13:32:32 he 2 variant s impact on 3 shot reduced protection vs hospitalization after 3 4 months compared with 1 is noteworthy https t co i jon gix

2022-05-25 13:19:34 xhibit for the people who don t think cases are important https t co 3 nsq y

2022-05-25 13:17:25 o infection of 1 and 2 detected by random sampling underlines the need for effective genomic surveillance to reduce the risk of generating o 2 recombinants with novel pathogenic and immunologic properties https t co n r h https t co e64 lrh73

2022-05-25 13:09:54 he 6th 2 12 1 2 wave esterday s over 140 000 new confirmed cases multiply by 7 for real number gt

2022-05-24 23:39:04 chrischirp his gap is more pronounced than previously reported by and concerning hat are your thoughts

2022-05-24 23:28:27 shley an peechless eartbroken urious 20 years since olumbine27 school shootings so far 14 babies not coming ho

2022-05-24 23:26:35 emmcnally xactly hanks for pointing that out

2022-05-24 23:16:26 able https t co 4y ts k or

2022-05-24 23:16:24 ew he ancet nf is eduction in vaccine booster effectiveness vs hospitalization for 2 vs 1 variants at 10 weeks https t co 6r29aba510 14 wks 70 2 vs 85 415 wks 56 5 vs 80 4 ee table below for 95 and text for detailsby freja kirsebom and colleagues https t co m 0t2js

2022-05-24 23:07:24 clairlemon hat kind of country lets their children be massacred at school

2022-05-24 23:06:19 nd now another heinous catastrophehttps t co gq 0w ym

2022-05-24 17:45:41 verall age breakdown and graphic https t co 6i nn fxf

2022-05-24 17:45:40 new on ong ovid supports its very high frequency and particular associated risks of cardiovascular neurologic respiratory diabetes kidney mental health and musculoskeletal involvementhttps t co l6ch h https t co q d h 9

2022-05-24 16:00:07 uke2315yee tell it like it is hen there s good news will post it f you only want happy talk don t follow me

2022-05-24 15:52:39 2 12 1 now dominant is the 58 of new cases gov https t co x ud4 uaov

2022-05-24 15:32:48 he axis has to be expanded for 2 12 1 and 4 5 and further variants to come

2022-05-24 15:12:31 ith maximal exercise aerosol particle emission increased an average of 132 foldhttps t co s i8 9 1 ews hese data not only explain o 2 transmissions during indoor group exercise but also can be used to design better targeted mitigation measures https t co 2 j5e k

2022-05-24 14:25:04 ust published cience agazine rom analysis of gt

2022-05-24 13:48:31 ontrary to the perception that recent variants have become successively milder micron 2 was associated with reporting more symptoms with greater disruption to daily activities than 1 2 vs 1 igure https t co e mum 7w https t co 01h7din m

2022-05-20 08:11:00 CAFIAC FIX

2022-10-28 19:37:55 Long-lived plasma cells: real time, cell-by-cell time stamping of their immune response after vaccinationhttps://t.co/bKWGL3a5rp half-life of ~700 days in the mouse model @SciImmunology @MonashUni https://t.co/vRFXcnB8Jy

2022-10-28 18:50:00 Billion-dollar experiments to "escape scientific stagnation"https://t.co/t9uGywZXnS https://t.co/fhmXKtENt6

2022-10-28 17:21:41 @uche_blackstock I'm not going anywhere, Uché. That's how I first met you

2022-10-28 17:18:01 @Nate_DiCamillo @CellCellPress unlocking the article https://t.co/8OakGeNT0I

2022-10-28 17:08:59 The case for some vigorous physical activity: association with reduced mortality, heart disease and cancer in ~72,000 people, mean age 63, followed ~6 yearshttps://t.co/h6XY9Cqms4@ESC_Journals @uk_biobank @Matthew_Ahmadi_ @M_Stamatakis https://t.co/pzYJf68EsU

2022-10-28 16:54:42 "Compelling evidence for the role of carboxylic acid in guiding the mosquito's preference toward specific people"https://t.co/wredsoM8ux @CellCellPress https://t.co/EvMS4VES25

2022-10-28 16:32:26 via @chrischirp In England, the share of cases (and spurt) of BQ.1.1 and BQ.1 is similar to the USHospital admissions are currently on the way down (for now at least) https://t.co/FmfnifCxAT

2022-10-28 15:17:45 @ACPinternists @scrippsresearch Thanks @ACPinternists!

2022-10-28 15:15:25 Besides the hopeful sign from France noted yesterday https://t.co/I4ujEQvJgw Region 2 of the US has the highest BQ.1.1/1, particularly New York, where new hospital admits have not shown a recent rise https://t.co/rcWUlpd8dk

2022-10-28 14:55:38 New US Covid genomics: BQ.1.1 and BQ.1 variants now account for 27% of cases, up from 17% a week ago, on a path to be dominant (>

2022-10-27 22:28:59 On a related front, metabolites from a specific gut microbiome bacterium in people with inflammatory bowel disease can promote tumor developmenthttps://t.co/6NNwlJvWmMhttps://t.co/hPXcuOt3ID https://t.co/72VEts7Soa

2022-10-27 22:15:34 Operation Nasal Vaccine. Please.https://t.co/OujfFxMgU6 @SciImmunology https://t.co/CtoZneSx9O

2022-10-27 21:49:26 Thanks to the swientists!https://t.co/YhPoxt6gaO @ScienceMagazine by @sciencecohen https://t.co/N48xJOHv12

2022-10-27 21:47:32 and this https://t.co/RnhEX54VOD

2022-10-27 19:11:59 @CathyLozupone @KristiKuhn @cu_medicine Agree!

2022-10-27 19:06:02 @BenIsraelow Delighted to do so, especially when it's so impressive and gives us much hope for a far better approach/defense

2022-10-27 18:30:09 Protective efficacy of the spike booster lasted for ~4 months, pan-sarbecovirus, using no adjuvants or replication-deficient or live attenuated virus (like FluMist), elicited broad neutralizing Abs.This is the variant-proof booster we need now to help prevent infections &

2022-10-27 18:16:56 Just published @ScienceMagazine A nasal vaccine booster (after primary vaccination) induces mucosal immunity —IgA, memory B and T cell—against the sarbecovirus family in the experimental modelhttps://t.co/j03xNjIXzhby @VirusesImmunity @tianyangmao and team @YaleIBIO @YaleMed https://t.co/M6LQUZWnlc

2022-10-27 17:44:25 RT @MassMedical: .@EricTopol said it would be a mistake to skip these shots. They still work, they just may not be much of an improvement o…

2022-10-27 17:39:01 Very hopeful signFrance is the 1st country in Europe to see the BQ.1.1 variant dominance (>

2022-10-26 21:05:00 The benefit of vaccination and boosters, along with prior Covid, against Omicron infections, in the California prison systemhttps://t.co/VSwHQIkwrD @NEJM https://t.co/3xg2Yn8DBm

2022-10-26 18:42:07 @Alexander_Tin @CNN @US_FDA @moderna_tx The number of participants in each of the 2 bivalent BA.5 booster independent studies is far greater than the ones Pfizer and Moderna have thus presented (zero) and are quite typical for assessment of neutralizing antibody response throughput the pandemic

2022-10-24 01:51:07 That Singapore's XBB variant wave was not severe, with relaxed mitigation, as @Fiona_M_Russell points out, is v encouraging https://t.co/tJuJ82OOBO —XBB's immune evasion could've ->

2022-10-24 01:21:15 @BagaiDr Many thanks Dr, Bagai!

2022-10-23 20:54:45 A booster is your best shot now. Why?https://t.co/G9Gnosk8E8

2022-10-23 18:04:32 It's not a good sign when 3 shots and a breakthrough (BA.1) infection (lower panel) doesn't elicit neutralizing antibodies to some of the new variants (BQ.1.1, XBB, BA.2.75.2) https://t.co/YS9rbTlSGZ

2022-10-23 16:21:46 RT @paula_span: The new bivalent COVID booster: Older folks, a highly vaccinated group, appear less interested in getting it than earlier s…

2022-10-23 16:17:42 @elderconsult I think the likely explanation is a high rate of prior infection, particularly with the Beta variant which seems to provide more cross-immunity than the others

2022-10-22 22:09:29 Thanks for the critique and feedback, @AstroKatie, @choo_ek and many others. A sense of equivalency was never intended. Preventing deaths, hospitalizations and #LongCovid towers over any liabilities.Here's a fixed version https://t.co/hrlYbI8rEI

2022-10-22 20:10:45 For the first year of vaccines, over 20 million lives saved around the world through December 2021 https://t.co/4GnPgEvg7W

2022-10-22 20:10:44 End of July 202291% reduction of deaths, all ages https://t.co/GIPkSo2daH

2022-10-22 20:10:42 Vaccines and boosters save lives. Across all ages.96% reduction of deaths for 2 boosters vs unvaccinatedEnd of May 2022@OurWorldInData https://t.co/UYkn5iszKT

2022-10-22 19:52:45 RT @cshperspectives: Sci comm irony when the first scientist quoted in a story has deleted their twitter account by the time the article ap…

2022-10-22 19:51:15 @JusDayDa @_TheAncientOne_ @MoritzGerstung Yes, that one is good, too. I had summarized it yesterdayhttps://t.co/fS78A4Vrwr

2022-10-22 19:32:01 @JusDayDa @MoritzGerstung Best I've seen is from @yunlong_cao and colleagueshttps://t.co/qWJ4AGtiur

2022-10-22 19:29:06 Avoiding #LongCovidhttps://t.co/VIVNew8bGWMy interview with @maggiemfox @Medscape, video w/ transcript https://t.co/FOpoBMAEOe

2022-10-22 16:59:36 A review of how #AI has been used during the pandemichttps://t.co/tvjS0ifKFE @PLOSDigiHealth "No clinical trials evaluating any applications impact on patient health" by @RANDCorporation @carlberdahl https://t.co/GeoWpysyyj

2022-10-22 15:31:45 The BQ.1.x wave projection for the US, and calculations for many other countries based on growth advantage vs BA.5, by @MoritzGerstung https://t.co/4TozbJWNLa https://t.co/wtuI1qLi4r

2022-10-22 14:15:56 Their XBB wave was projected to exceed BA.5.Strong NPI mitigation practices and very high vaccine/booster uptake (a top 10 country) likely contributed https://t.co/93Vd3T3Qg2

2022-10-22 14:05:17 This is very good news.The XBB variant wave in Singapore is in descenthttps://t.co/mZS5FePzrNXBB and BQ.1.1 are 2 of the most immune evasive variants and Singapore was the first country to experience a wave induced by one of them, now letting up https://t.co/DbkSC4OPN7

2022-10-22 01:27:48 @BMcranty @AstroKatie @Sarcasmorator I don't consider major reduction of deaths, hospitalizations, and #LongCovid as "meh"

2022-10-21 22:51:43 91% reduction of Covid deaths for age 50+ with 2 boosters, August 2022, vs unvaccinated BA.5 wave https://t.co/HGyjNwCm0v https://t.co/VI7LzxaLtM

2022-10-21 22:11:19 @AstroKatie I'm with you. Trying to provide as much balance as possible

2022-10-21 22:08:33 Yesterday's @CDCMMWR report that shows slippage of protection vs hospitalization after 4 months, age 18+, during BA.5 wavehttps://t.co/DRB7tiyffU https://t.co/1bTzbZvhAv

2022-10-21 22:05:10 @Sara43347888 The answer is NO. The @sfchronicle headline is terrible and worse than that is to have it behind a paywall. Unacceptable.

2022-10-21 22:01:41 For ages 18-49, the 72% reduction of Covid hospitalizations with ≥ boosterhttps://t.co/M2Bu9rj1Ve https://t.co/DX8wcxAzzt

2022-10-21 21:48:59 Since Omicron in late 2021, mRNA booster protection vs infections &

2022-10-21 20:53:57 @JohnRossMD That's one of several refutes See @K_G_Andersen https://t.co/HcVEo29XaAAnd @Friedemann1https://t.co/VJCmgWR1Vj

2022-10-21 20:45:55 RT @JohnRossMD: In case you missed it, UK COVID minimizer Francois Balloux has deleted his account after amplifying a spectacularly wrong p…

2022-10-21 18:27:42 RT @JReinerMD: Pfizer projects that it will make $32 billion from its COVID vaccine in 2022 and $22 billion from Paxlovid. Their plan to ch…

2022-10-21 17:41:28 The BQ variants and the UShttps://t.co/KEeCny0P9A by @ErinMPrater @FortuneMagazine

2022-10-21 16:36:27 RT @K_G_Andersen: BQ.1(.1)* picking up steam, but still too low to be making a major difference in cases/hospitalizations - follow this tre…

2022-10-21 15:59:15 That's right—Covid boosters aren't for everyone.But for WSJ to print this seriously flawed claim about cardiac deaths in men age 18-39 is inappropriate, to say the least https://t.co/KCox0mhlHG https://t.co/NixQ2Uki1R

2022-10-21 15:02:26 New lab assessment of these variantsBQ.1.1 has the most immune evasion and fusogenicityhttps://t.co/5FQn5FxOZ1 https://t.co/PmZPkQHB4n

2022-10-21 14:50:01 What are the #SARSCoV2 variants accounting for US cases?New CDC genomic surveillance updateOn the rise: Predominantly BQ.1 and BQ.1.1 (~17%), also BF.7 (7%), BA.2.75.2On the decline: BA.5, BA.4.6https://t.co/jjl2AnwOWX https://t.co/r7i6cYnjSe

2022-10-21 14:37:20 RT @mhornig: Not convinced efforts to avoid #SARSCoV2 infx are worth it? Think #LongCOVID and potential for #MECFS are fantasy? Please list…

2022-10-21 14:20:48 Myalgic encephalomyelitis was first recorded in 1934 in Los Angeles after an outbreak of atypical polio. It has taken nearly a century and #LongCovid to "get needed attention"https://t.co/ryyI15mfnf @NanetteAsimov #mecfs https://t.co/xOYiOk9R2A

2022-10-21 02:54:11 Keep an eye on New York, leading the country with % cases BQ.1.1, bellwether for the next wave https://t.co/vw77IAyHJj (update, first picked up by @JPWeiland) https://t.co/MPJSVvzqEY

2022-10-21 01:50:07 The inversion (next wave) is likely starting by the rise in hospitalizations. Great time for CDC to stop daily tracking https://t.co/RXymG9t41x

2022-10-20 23:56:25 On the imprinting issue, in the Discussion"antibody responses to some Omicron S[spike]-specific epitopes were hindered by prior antigenic exposure" https://t.co/w9oiWH8s5A

2022-10-20 22:39:04 Is the science information credible? For the competent outsider:https://t.co/cuyEKL762s@danrpimentel @ScienceMagazine https://t.co/z8WsB1TOjF

2022-10-20 20:02:03 The mechanism by which time-restricted eating limits obesity (in mice)https://t.co/gENt2Muxtq@DamienLagarde @kazaklab @ScienceMagazine @ScienceVisualsre:https://t.co/DN3oCsON5y@JoeBass91471540 and colleagues https://t.co/iVqHsgvAy8

2022-10-20 18:57:29 Vaccination alone did not induce neutralizing activity in the nasal mucosa, but that was achieved via breakthrough infections."These observations... .motivate the development and evaluation of a next generation of vaccines administered intranasally." https://t.co/XIaSiKDJ7R

2022-10-20 18:36:12 "We identified an ultrapotent pan-variant neutralizing antibody, that is a strong candidate for clinical development."https://t.co/jlo7fjwCr5@ScienceMagazine @veeslerlab https://t.co/bwBA8q2zfQ

2022-10-20 18:30:15 A feature @ScienceMagazine on what to do about lab virus work https://t.co/aZhzc3k7X8 by @jocelynkaiser https://t.co/Ypyp24G90K

2022-10-20 17:17:31 Also to note that 60%+ max is not the 80%+ protection vs hospitalization that was consistently seen prior to BA.5, (90%+ for Delta and prior strains) and that finding replicates 2 other studies.Underscores the importance and need for a variant-proof, pan-sarbecovirus vaccine

2022-10-20 17:07:07 Why a booster is important to maintain protection from hospitalization: waning immunityNew @CDCMMWR shows the protection vs BA.5 drops down to 37% (2 shots) and 29% (3 shots) after 4 monthshttps://t.co/DRB7tiyffUData are for all ages 18+ https://t.co/Pa0PtdlWIY

2022-10-20 15:30:35 In a prospective cohort of critically ill adults, sequencing the blood (metagenomics) identified the pathogen 99% and predicted sepsis in 74%https://t.co/tQTgyQHSjY@NatureMicrobiol @UCSF @klkalantar and colleagues https://t.co/wx4u4HpqD5

2022-10-20 13:33:04 "Middle-aged people accounted for the biggest losses in life expectancy"https://t.co/czRQeP2WkHMore at "In America and eastern Europe, covid-19 got worse in 2021" https://t.co/SxZup76Cic

2022-10-20 12:47:01 RT @bmj_latest: “This virus is so amenable to taking it down . . . But we’re just not acting like we can do this. And we can.” @EricTopol…

2022-10-20 01:56:23 RT @EricTopol: There's a lot of total BS out there about myocarditis in kids and adolescents. To state facts:1. CDC does NOT decide about…

2022-10-19 22:20:40 For children 5-11 years in males, 2nd dosethe rate is 2.5 per million https://t.co/kXEH3wMsZl

2022-10-19 22:14:25 There's a lot of total BS out there about myocarditis in kids and adolescents. To state facts:1. CDC does NOT decide about Covid vaccines in schools 2. There are no kids dying of myocarditis from the vaccines3. It is very rare, mild 4. The anti-vaxx world has gone beserk

2022-10-19 21:56:45 The BA.4.6 variant accounts for ~12% of US Covid cases (pattern of growth below, left). Its level of immune escape was characterized @NEJM today: 2-3 fold less neutralizing antibodies than BA.5 (below, right)https://t.co/WdRlUvagsW @BarouchLab https://t.co/HCJYiczVfX

2022-10-19 21:38:19 A timely, outstanding @NEJM review on myocarditis today https://t.co/WAT7pvAMZX by @Cristinabasso64 https://t.co/kx9NytqNro

2022-10-19 21:06:24 Randomized, placebo-controlled trial of the 2-dose @moderna_tx vaccine in children 6 months to 5 years, during Omicron. Safe in ~4,800 kids

2022-10-19 21:00:25 New @NEJM"Our study indicates that [Pfizer] vaccine-induced myocarditis in adolescents appears to be a rare adverse event [<

2022-10-19 19:10:16 "Alexa, what's a mechanical neural network?"https://t.co/3d8yQNsBO1 @SciRobotics #AI https://t.co/X5TbigpMCa

2022-10-19 18:00:25 4. No increased risk of miscarriage or other pregnancy complications from vaccination or booster https://t.co/mVFxD3aE8e

2022-10-19 18:00:23 3. Newborn/infant (0-5 months) avoidance of hospitalization by mother's vaccination https://t.co/T2Wut9L6kK

2022-10-19 18:00:21 2. Vaccination protected vs hospitalization vs Delta and Omicron infections with booster (same with ED or urgent care visits)But 57% of expectant mothers have not been vaccinated or had a booster https://t.co/e9BEJwfVse

2022-10-29 19:05:35 The #1 sleuth of life science data manipulation and imaging fraud, @MicrobiomDigest, has analyzed more than 100,000 papers since 2014. She reviews what she's learned and lays out what needs to change https://t.co/AYjYeVcrTP@nytopinion https://t.co/gw75OwQZb7

2022-10-29 17:49:56 @DrSidMukherjee Thinking back. Funny that I reviewed The Gene in Cellhttps://t.co/PYMcpbr1zj https://t.co/fYcV8huFOV

2022-10-29 17:27:33 Q—Before the pandemic, when was the last time an intervention's efficacy and safety was validated in >

2022-10-29 16:27:22 Song of the Cell, @DrSidMukherjee's new book, is an extraordinary work that covers the cell's history and future, along with its mysteries, like he did for genes in The Gene. Reviewed by @DShaywitz @WSJhttps://t.co/ec8WVRk0T6 https://t.co/YUSxRINVEb

2022-10-29 15:25:57 A ranking of the immune evasion for the new variantshttps://t.co/1lrjUMGa9X

2022-10-29 15:21:45 Good summary of the variant swarm/soup status @nature by @ewencallaway with @CorneliusRoemer @yunlong_cao https://t.co/wNwFgdLkvC https://t.co/jvAaShLJqh

2022-10-29 15:15:15 An encouraging sign for one of the (if not the) most immune evasive new variantsXBB is dominant in India and Bangladesh without a rise in cases or deaths to datehttps://t.co/kraBgpFU4V and @OurWorldInData https://t.co/oZdLOXtoSI

2022-10-28 19:37:55 Long-lived plasma cells: real time, cell-by-cell time stamping of their immune response after vaccinationhttps://t.co/bKWGL3a5rp half-life of ~700 days in the mouse model @SciImmunology @MonashUni https://t.co/vRFXcnB8Jy

2022-10-28 18:50:00 Billion-dollar experiments to "escape scientific stagnation"https://t.co/t9uGywZXnS https://t.co/fhmXKtENt6

2022-10-28 17:21:41 @uche_blackstock I'm not going anywhere, Uché. That's how I first met you

2022-10-28 17:18:01 @Nate_DiCamillo @CellCellPress unlocking the article https://t.co/8OakGeNT0I

2022-10-28 17:08:59 The case for some vigorous physical activity: association with reduced mortality, heart disease and cancer in ~72,000 people, mean age 63, followed ~6 yearshttps://t.co/h6XY9Cqms4@ESC_Journals @uk_biobank @Matthew_Ahmadi_ @M_Stamatakis https://t.co/pzYJf68EsU

2022-10-28 16:54:42 "Compelling evidence for the role of carboxylic acid in guiding the mosquito's preference toward specific people"https://t.co/wredsoM8ux @CellCellPress https://t.co/EvMS4VES25

2022-10-28 16:32:26 via @chrischirp In England, the share of cases (and spurt) of BQ.1.1 and BQ.1 is similar to the USHospital admissions are currently on the way down (for now at least) https://t.co/FmfnifCxAT

2022-10-28 15:17:45 @ACPinternists @scrippsresearch Thanks @ACPinternists!

2022-10-28 15:15:25 Besides the hopeful sign from France noted yesterday https://t.co/I4ujEQvJgw Region 2 of the US has the highest BQ.1.1/1, particularly New York, where new hospital admits have not shown a recent rise https://t.co/rcWUlpd8dk

2022-10-28 14:55:38 New US Covid genomics: BQ.1.1 and BQ.1 variants now account for 27% of cases, up from 17% a week ago, on a path to be dominant (>

2022-10-27 22:28:59 On a related front, metabolites from a specific gut microbiome bacterium in people with inflammatory bowel disease can promote tumor developmenthttps://t.co/6NNwlJvWmMhttps://t.co/hPXcuOt3ID https://t.co/72VEts7Soa

2022-10-27 22:15:34 Operation Nasal Vaccine. Please.https://t.co/OujfFxMgU6 @SciImmunology https://t.co/CtoZneSx9O

2022-10-27 21:49:26 Thanks to the swientists!https://t.co/YhPoxt6gaO @ScienceMagazine by @sciencecohen https://t.co/N48xJOHv12

2022-10-27 21:47:32 and this https://t.co/RnhEX54VOD

2022-10-27 19:11:59 @CathyLozupone @KristiKuhn @cu_medicine Agree!

2022-10-27 19:06:02 @BenIsraelow Delighted to do so, especially when it's so impressive and gives us much hope for a far better approach/defense

2022-10-27 18:30:09 Protective efficacy of the spike booster lasted for ~4 months, pan-sarbecovirus, using no adjuvants or replication-deficient or live attenuated virus (like FluMist), elicited broad neutralizing Abs.This is the variant-proof booster we need now to help prevent infections &

2022-10-27 18:16:56 Just published @ScienceMagazine A nasal vaccine booster (after primary vaccination) induces mucosal immunity —IgA, memory B and T cell—against the sarbecovirus family in the experimental modelhttps://t.co/j03xNjIXzhby @VirusesImmunity @tianyangmao and team @YaleIBIO @YaleMed https://t.co/M6LQUZWnlc

2022-10-27 17:44:25 RT @MassMedical: .@EricTopol said it would be a mistake to skip these shots. They still work, they just may not be much of an improvement o…

2022-10-27 17:39:01 Very hopeful signFrance is the 1st country in Europe to see the BQ.1.1 variant dominance (>

2022-10-26 21:05:00 The benefit of vaccination and boosters, along with prior Covid, against Omicron infections, in the California prison systemhttps://t.co/VSwHQIkwrD @NEJM https://t.co/3xg2Yn8DBm

2022-10-26 18:42:07 @Alexander_Tin @CNN @US_FDA @moderna_tx The number of participants in each of the 2 bivalent BA.5 booster independent studies is far greater than the ones Pfizer and Moderna have thus presented (zero) and are quite typical for assessment of neutralizing antibody response throughput the pandemic

2022-10-24 01:51:07 That Singapore's XBB variant wave was not severe, with relaxed mitigation, as @Fiona_M_Russell points out, is v encouraging https://t.co/tJuJ82OOBO —XBB's immune evasion could've ->

2022-10-24 01:21:15 @BagaiDr Many thanks Dr, Bagai!

2022-10-23 20:54:45 A booster is your best shot now. Why?https://t.co/G9Gnosk8E8

2022-10-23 18:04:32 It's not a good sign when 3 shots and a breakthrough (BA.1) infection (lower panel) doesn't elicit neutralizing antibodies to some of the new variants (BQ.1.1, XBB, BA.2.75.2) https://t.co/YS9rbTlSGZ

2022-10-23 16:21:46 RT @paula_span: The new bivalent COVID booster: Older folks, a highly vaccinated group, appear less interested in getting it than earlier s…

2022-10-23 16:17:42 @elderconsult I think the likely explanation is a high rate of prior infection, particularly with the Beta variant which seems to provide more cross-immunity than the others

2022-10-22 22:09:29 Thanks for the critique and feedback, @AstroKatie, @choo_ek and many others. A sense of equivalency was never intended. Preventing deaths, hospitalizations and #LongCovid towers over any liabilities.Here's a fixed version https://t.co/hrlYbI8rEI

2022-10-22 20:10:45 For the first year of vaccines, over 20 million lives saved around the world through December 2021 https://t.co/4GnPgEvg7W

2022-10-22 20:10:44 End of July 202291% reduction of deaths, all ages https://t.co/GIPkSo2daH

2022-10-22 20:10:42 Vaccines and boosters save lives. Across all ages.96% reduction of deaths for 2 boosters vs unvaccinatedEnd of May 2022@OurWorldInData https://t.co/UYkn5iszKT

2022-10-22 19:52:45 RT @cshperspectives: Sci comm irony when the first scientist quoted in a story has deleted their twitter account by the time the article ap…

2022-10-22 19:51:15 @JusDayDa @_TheAncientOne_ @MoritzGerstung Yes, that one is good, too. I had summarized it yesterdayhttps://t.co/fS78A4Vrwr

2022-10-22 19:32:01 @JusDayDa @MoritzGerstung Best I've seen is from @yunlong_cao and colleagueshttps://t.co/qWJ4AGtiur

2022-10-22 19:29:06 Avoiding #LongCovidhttps://t.co/VIVNew8bGWMy interview with @maggiemfox @Medscape, video w/ transcript https://t.co/FOpoBMAEOe

2022-10-22 16:59:36 A review of how #AI has been used during the pandemichttps://t.co/tvjS0ifKFE @PLOSDigiHealth "No clinical trials evaluating any applications impact on patient health" by @RANDCorporation @carlberdahl https://t.co/GeoWpysyyj

2022-10-22 15:31:45 The BQ.1.x wave projection for the US, and calculations for many other countries based on growth advantage vs BA.5, by @MoritzGerstung https://t.co/4TozbJWNLa https://t.co/wtuI1qLi4r

2022-10-22 14:15:56 Their XBB wave was projected to exceed BA.5.Strong NPI mitigation practices and very high vaccine/booster uptake (a top 10 country) likely contributed https://t.co/93Vd3T3Qg2

2022-10-22 14:05:17 This is very good news.The XBB variant wave in Singapore is in descenthttps://t.co/mZS5FePzrNXBB and BQ.1.1 are 2 of the most immune evasive variants and Singapore was the first country to experience a wave induced by one of them, now letting up https://t.co/DbkSC4OPN7

2022-10-22 01:27:48 @BMcranty @AstroKatie @Sarcasmorator I don't consider major reduction of deaths, hospitalizations, and #LongCovid as "meh"

2022-10-21 22:51:43 91% reduction of Covid deaths for age 50+ with 2 boosters, August 2022, vs unvaccinated BA.5 wave https://t.co/HGyjNwCm0v https://t.co/VI7LzxaLtM

2022-10-21 22:11:19 @AstroKatie I'm with you. Trying to provide as much balance as possible

2022-10-21 22:08:33 Yesterday's @CDCMMWR report that shows slippage of protection vs hospitalization after 4 months, age 18+, during BA.5 wavehttps://t.co/DRB7tiyffU https://t.co/1bTzbZvhAv

2022-10-21 22:05:10 @Sara43347888 The answer is NO. The @sfchronicle headline is terrible and worse than that is to have it behind a paywall. Unacceptable.

2022-10-21 22:01:41 For ages 18-49, the 72% reduction of Covid hospitalizations with ≥ boosterhttps://t.co/M2Bu9rj1Ve https://t.co/DX8wcxAzzt

2022-10-21 21:48:59 Since Omicron in late 2021, mRNA booster protection vs infections &

2022-10-21 20:53:57 @JohnRossMD That's one of several refutes See @K_G_Andersen https://t.co/HcVEo29XaAAnd @Friedemann1https://t.co/VJCmgWR1Vj

2022-10-21 20:45:55 RT @JohnRossMD: In case you missed it, UK COVID minimizer Francois Balloux has deleted his account after amplifying a spectacularly wrong p…

2022-10-21 18:27:42 RT @JReinerMD: Pfizer projects that it will make $32 billion from its COVID vaccine in 2022 and $22 billion from Paxlovid. Their plan to ch…

2022-10-21 17:41:28 The BQ variants and the UShttps://t.co/KEeCny0P9A by @ErinMPrater @FortuneMagazine

2022-10-21 16:36:27 RT @K_G_Andersen: BQ.1(.1)* picking up steam, but still too low to be making a major difference in cases/hospitalizations - follow this tre…

2022-10-21 15:59:15 That's right—Covid boosters aren't for everyone.But for WSJ to print this seriously flawed claim about cardiac deaths in men age 18-39 is inappropriate, to say the least https://t.co/KCox0mhlHG https://t.co/NixQ2Uki1R

2022-10-21 15:02:26 New lab assessment of these variantsBQ.1.1 has the most immune evasion and fusogenicityhttps://t.co/5FQn5FxOZ1 https://t.co/PmZPkQHB4n

2022-10-21 14:50:01 What are the #SARSCoV2 variants accounting for US cases?New CDC genomic surveillance updateOn the rise: Predominantly BQ.1 and BQ.1.1 (~17%), also BF.7 (7%), BA.2.75.2On the decline: BA.5, BA.4.6https://t.co/jjl2AnwOWX https://t.co/r7i6cYnjSe

2022-10-21 14:37:20 RT @mhornig: Not convinced efforts to avoid #SARSCoV2 infx are worth it? Think #LongCOVID and potential for #MECFS are fantasy? Please list…

2022-10-21 14:20:48 Myalgic encephalomyelitis was first recorded in 1934 in Los Angeles after an outbreak of atypical polio. It has taken nearly a century and #LongCovid to "get needed attention"https://t.co/ryyI15mfnf @NanetteAsimov #mecfs https://t.co/xOYiOk9R2A

2022-10-21 02:54:11 Keep an eye on New York, leading the country with % cases BQ.1.1, bellwether for the next wave https://t.co/vw77IAyHJj (update, first picked up by @JPWeiland) https://t.co/MPJSVvzqEY

2022-10-21 01:50:07 The inversion (next wave) is likely starting by the rise in hospitalizations. Great time for CDC to stop daily tracking https://t.co/RXymG9t41x

2022-10-20 23:56:25 On the imprinting issue, in the Discussion"antibody responses to some Omicron S[spike]-specific epitopes were hindered by prior antigenic exposure" https://t.co/w9oiWH8s5A

2022-10-20 22:39:04 Is the science information credible? For the competent outsider:https://t.co/cuyEKL762s@danrpimentel @ScienceMagazine https://t.co/z8WsB1TOjF

2022-10-20 20:02:03 The mechanism by which time-restricted eating limits obesity (in mice)https://t.co/gENt2Muxtq@DamienLagarde @kazaklab @ScienceMagazine @ScienceVisualsre:https://t.co/DN3oCsON5y@JoeBass91471540 and colleagues https://t.co/iVqHsgvAy8

2022-10-20 18:57:29 Vaccination alone did not induce neutralizing activity in the nasal mucosa, but that was achieved via breakthrough infections."These observations... .motivate the development and evaluation of a next generation of vaccines administered intranasally." https://t.co/XIaSiKDJ7R

2022-10-20 18:36:12 "We identified an ultrapotent pan-variant neutralizing antibody, that is a strong candidate for clinical development."https://t.co/jlo7fjwCr5@ScienceMagazine @veeslerlab https://t.co/bwBA8q2zfQ

2022-10-20 18:30:15 A feature @ScienceMagazine on what to do about lab virus work https://t.co/aZhzc3k7X8 by @jocelynkaiser https://t.co/Ypyp24G90K

2022-10-20 17:17:31 Also to note that 60%+ max is not the 80%+ protection vs hospitalization that was consistently seen prior to BA.5, (90%+ for Delta and prior strains) and that finding replicates 2 other studies.Underscores the importance and need for a variant-proof, pan-sarbecovirus vaccine

2022-10-20 17:07:07 Why a booster is important to maintain protection from hospitalization: waning immunityNew @CDCMMWR shows the protection vs BA.5 drops down to 37% (2 shots) and 29% (3 shots) after 4 monthshttps://t.co/DRB7tiyffUData are for all ages 18+ https://t.co/Pa0PtdlWIY

2022-10-20 15:30:35 In a prospective cohort of critically ill adults, sequencing the blood (metagenomics) identified the pathogen 99% and predicted sepsis in 74%https://t.co/tQTgyQHSjY@NatureMicrobiol @UCSF @klkalantar and colleagues https://t.co/wx4u4HpqD5

2022-10-20 13:33:04 "Middle-aged people accounted for the biggest losses in life expectancy"https://t.co/czRQeP2WkHMore at "In America and eastern Europe, covid-19 got worse in 2021" https://t.co/SxZup76Cic

2022-10-20 12:47:01 RT @bmj_latest: “This virus is so amenable to taking it down . . . But we’re just not acting like we can do this. And we can.” @EricTopol…

2022-10-20 01:56:23 RT @EricTopol: There's a lot of total BS out there about myocarditis in kids and adolescents. To state facts:1. CDC does NOT decide about…

2022-10-19 22:20:40 For children 5-11 years in males, 2nd dosethe rate is 2.5 per million https://t.co/kXEH3wMsZl

2022-10-19 22:14:25 There's a lot of total BS out there about myocarditis in kids and adolescents. To state facts:1. CDC does NOT decide about Covid vaccines in schools 2. There are no kids dying of myocarditis from the vaccines3. It is very rare, mild 4. The anti-vaxx world has gone beserk

2022-10-19 21:56:45 The BA.4.6 variant accounts for ~12% of US Covid cases (pattern of growth below, left). Its level of immune escape was characterized @NEJM today: 2-3 fold less neutralizing antibodies than BA.5 (below, right)https://t.co/WdRlUvagsW @BarouchLab https://t.co/HCJYiczVfX

2022-10-19 21:38:19 A timely, outstanding @NEJM review on myocarditis today https://t.co/WAT7pvAMZX by @Cristinabasso64 https://t.co/kx9NytqNro

2022-10-19 21:06:24 Randomized, placebo-controlled trial of the 2-dose @moderna_tx vaccine in children 6 months to 5 years, during Omicron. Safe in ~4,800 kids

2022-10-19 21:00:25 New @NEJM"Our study indicates that [Pfizer] vaccine-induced myocarditis in adolescents appears to be a rare adverse event [<

2022-10-19 19:10:16 "Alexa, what's a mechanical neural network?"https://t.co/3d8yQNsBO1 @SciRobotics #AI https://t.co/X5TbigpMCa

2022-10-19 18:00:25 4. No increased risk of miscarriage or other pregnancy complications from vaccination or booster https://t.co/mVFxD3aE8e

2022-10-19 18:00:23 3. Newborn/infant (0-5 months) avoidance of hospitalization by mother's vaccination https://t.co/T2Wut9L6kK

2022-10-19 18:00:21 2. Vaccination protected vs hospitalization vs Delta and Omicron infections with booster (same with ED or urgent care visits)But 57% of expectant mothers have not been vaccinated or had a booster https://t.co/e9BEJwfVse

2022-11-18 00:42:08 By current variant growth advantage patterns, the next couple of months in the US will be BQ.1.x dominated. Bivalent boosters will help protect

2022-11-18 00:20:49 @WHCOS Nicely put, Ron. Thanks!

2022-11-18 00:20:19 RT @WHCOS: In simpler terms: Go get your new COVID vaccination now.

2022-11-18 00:06:48 What science forgot during the pandemic https://t.co/12ffbs3ZOF by @richardhorton1 @TheLancet https://t.co/aoJSA3dEco

2022-11-17 23:56:45 A new report confirms the immune escape of the BQ.1.1 variant, along with BA.4.6 &

2022-11-17 23:26:54 We still don't have a way to diagnosis chronic traumatic encephalopathy (CTE) in people who are alive, but may be getting closer https://t.co/SftRQR7TWD by @el_belson @NYTSports https://t.co/BTh6oXUxRg

2022-11-17 21:47:06 RT @rowlsmanthorpe: Long covid has wrecked my life It’s bad, very bad. But you knew that already I want to tell you a hopeful story. A st…

2022-11-17 19:37:27 @PraliNoisette I don't see any sign of that https://t.co/e7u7aZCfBZ

2022-11-17 19:12:51 To note https://t.co/y2qdjFrvDR

2022-11-17 19:11:30 75 years later we have chips with >

2022-11-17 18:08:47 BA.5, déjà vu https://t.co/eILO8PxIkY

2022-11-17 17:33:41 RT @linseymarr: You get a 2-for-1 with filtration. It removes virus from the air and PM2.5 that is associated with an increased risk of inf…

2022-11-17 17:28:45 RT @Aiims1742: Important #OpenAccess paper in @Cancer_Cell from @CharlesSwanton &

2022-11-17 17:09:54 Strong evidence that particulate matter air pollution (ambient PM2.5) increases the risk of Covid infection, a systematic analysis https://t.co/RueG44Hk2m @MonashUni https://t.co/kpREoqJVPi

2022-11-17 15:46:50 About 1 in 5 of us have an APOE4 gene variant, the #1 genetic risk factor for Alzheimer's disease. But the mechanism for brain injury was a mystery, now getting unraveled (cholesterol processing by oligodendrocytes) https://t.co/gIpGt0CA28 @nature https://t.co/hbmdpO6R3t https://t.co/4zFZIhUTCI

2022-11-17 01:27:50 @amitsurg Because they do. That's mostly related to the excess of rebound after Paxlovid

2022-11-17 00:58:05 We've (re-)learned a few important lessons from the Paxlovid rebound experience about randomized trials and real world evidence Reviewed here https://t.co/jmT9vIipg9

2022-11-16 19:46:41 The Paxlovid rebound story New data reviewed in the 16 November daily briefing of Ground Truths https://t.co/jmT9vIipg9

2022-11-16 17:48:15 The US Covid death rate (7-day average) drops below 300 for the first time since June 2022. Lowest since pandemic began was 222 in July 2021. https://t.co/Cze8bZgtVr https://t.co/uxGosRY1KO

2022-11-16 17:14:12 Immunotherapy can induce myocarditis but the mechanism has been poorly understood. A new report @nature today supports the culprit auto-antigen role of α-myosin and cytotoxic T-cells directed to it https://t.co/uPRUQBbkVh by @MargaretAxelrod @BalkoLab https://t.co/vWZP1IcW19

2022-11-16 16:37:07 Humidity (indoor, relative) is associated with outcomes of Covid infections, a population-based study in 121 countries https://t.co/dWMmyMfBSL https://t.co/hW7Jq1mhdo

2022-11-16 01:17:21 RT @PeterHotez: Important and well-conducted study by @EricTopol My take: even though rebound is real and significant, in my conversation…

2022-11-15 23:33:25 For the people pointing out that @POTUS, @CDCDirector and Tony Fauci all had Paxlovid rebound, that's why you do prospective, systematic studies. We've learned that "rebound" also occurs without Paxlovid and that anecdotes/twitter are not representative of the real world

2022-11-15 20:14:34 Each participant did rapid antigen testing every other day through day 15, symptom surveys through day 17, and are being followed for 6 months https://t.co/8bDtswdytR

2022-11-15 20:00:32 The event curves for Paxlovid treated compared with controls https://t.co/2ykeOuBUAX

2022-11-15 19:56:25 Our prospective Paxlovid rebound study with controls preprint is posted By symptoms: ~12% rebound (19% Pax vs 7% controls) By positive testing: ~5% rebound (14% Pax vs 9% controls) Much lower than many estimates https://t.co/czeGEYIJvA by @JayPandit @michaelmina_lab @ScrippsRTI

2022-11-15 19:45:43 Foundation #AI models come to science https://t.co/G7Xx31w1Of https://t.co/HNjVOs3J4I

2022-11-15 19:23:17 @Jdrodric12 that's right!

2022-11-15 18:47:56 @SarahWLaurence @ScrippsRTI Thank you!

2022-11-15 18:31:49 On a day when the world has reached about ~8 billion people, it's notable there have been >

2022-11-15 17:10:19 @surrogateexpare @Medscape Included here https://t.co/bugfFk44sh@Medscape Please fix the links

2022-11-15 17:09:38 This post has all the relevant links and review the recent its for protection vs #LongCovid https://t.co/bugfFk44sh

2022-11-15 16:30:20 Paxlovid interactionsA new report claims 14.6% of patients had contraindications to treatment. But most of these meds could have been safely stopped for 5 dayshttps://t.co/FP3o0J0eBzMore on this herehttps://t.co/i3pUyAJlAs @Medscape https://t.co/0tsAf3xUqu

2022-11-15 16:11:35 Start of new waves in South Korea and Japan, having sustained recent BA.5 waves and this variant still accounts for most new casesThe pandemic isn't over https://t.co/DhwWhZ4CJi

2022-11-15 16:01:28 Here's the article. A potential path to preventing brain tissue from dying https://t.co/ODGuD8X8iy

2022-11-15 00:48:03 Today's pandemic briefing on new booster data and the thick soup of new variantshttps://t.co/LA3nl6FxSx

2022-11-14 17:22:13 RT @danrdanny: Excited to see our work on 3-hour genome sequencing highlighted here! If you think this is interesting we have a bench scien…

2022-11-14 17:04:44 The potential for detecting heart dysfunction (ejection fraction <

2022-11-14 14:37:14 RT @EricTopol: Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so m…

2022-11-14 14:28:16 In aggregate, solid evidence that the bivalent booster elicits a strong and broadened neutralizing antibody immune response. Yet, less than 27% of Americans 65+, the have had it and poor uptake across all age groupshttps://t.co/V5Xlj3cKln

2022-11-14 14:28:15 https://t.co/fJbLUdcYJdCoverage @statnews by @matthewherper w/ @SutharLab, whose results were replicated by the new data (Table)

2022-11-14 12:00:01 Moderna BA.5 bivalent booster results announced (via @moderna_tx press release)—largest study to date of >

2022-11-18 00:42:08 By current variant growth advantage patterns, the next couple of months in the US will be BQ.1.x dominated. Bivalent boosters will help protect

2022-11-18 00:20:49 @WHCOS Nicely put, Ron. Thanks!

2022-11-18 00:20:19 RT @WHCOS: In simpler terms: Go get your new COVID vaccination now.

2022-11-18 00:06:48 What science forgot during the pandemic https://t.co/12ffbs3ZOF by @richardhorton1 @TheLancet https://t.co/aoJSA3dEco

2022-11-17 23:56:45 A new report confirms the immune escape of the BQ.1.1 variant, along with BA.4.6 &

2022-11-17 23:26:54 We still don't have a way to diagnosis chronic traumatic encephalopathy (CTE) in people who are alive, but may be getting closer https://t.co/SftRQR7TWD by @el_belson @NYTSports https://t.co/BTh6oXUxRg

2022-11-17 21:47:06 RT @rowlsmanthorpe: Long covid has wrecked my life It’s bad, very bad. But you knew that already I want to tell you a hopeful story. A st…

2022-11-17 19:37:27 @PraliNoisette I don't see any sign of that https://t.co/e7u7aZCfBZ

2022-11-17 19:12:51 To note https://t.co/y2qdjFrvDR

2022-11-17 19:11:30 75 years later we have chips with >

2022-11-17 18:08:47 BA.5, déjà vu https://t.co/eILO8PxIkY

2022-11-17 17:33:41 RT @linseymarr: You get a 2-for-1 with filtration. It removes virus from the air and PM2.5 that is associated with an increased risk of inf…

2022-11-17 17:28:45 RT @Aiims1742: Important #OpenAccess paper in @Cancer_Cell from @CharlesSwanton &

2022-11-17 17:09:54 Strong evidence that particulate matter air pollution (ambient PM2.5) increases the risk of Covid infection, a systematic analysis https://t.co/RueG44Hk2m @MonashUni https://t.co/kpREoqJVPi

2022-11-17 15:46:50 About 1 in 5 of us have an APOE4 gene variant, the #1 genetic risk factor for Alzheimer's disease. But the mechanism for brain injury was a mystery, now getting unraveled (cholesterol processing by oligodendrocytes) https://t.co/gIpGt0CA28 @nature https://t.co/hbmdpO6R3t https://t.co/4zFZIhUTCI

2022-11-17 01:27:50 @amitsurg Because they do. That's mostly related to the excess of rebound after Paxlovid

2022-11-17 00:58:05 We've (re-)learned a few important lessons from the Paxlovid rebound experience about randomized trials and real world evidence Reviewed here https://t.co/jmT9vIipg9

2022-11-16 19:46:41 The Paxlovid rebound story New data reviewed in the 16 November daily briefing of Ground Truths https://t.co/jmT9vIipg9

2022-11-16 17:48:15 The US Covid death rate (7-day average) drops below 300 for the first time since June 2022. Lowest since pandemic began was 222 in July 2021. https://t.co/Cze8bZgtVr https://t.co/uxGosRY1KO

2022-11-16 17:14:12 Immunotherapy can induce myocarditis but the mechanism has been poorly understood. A new report @nature today supports the culprit auto-antigen role of α-myosin and cytotoxic T-cells directed to it https://t.co/uPRUQBbkVh by @MargaretAxelrod @BalkoLab https://t.co/vWZP1IcW19

2022-11-16 16:37:07 Humidity (indoor, relative) is associated with outcomes of Covid infections, a population-based study in 121 countries https://t.co/dWMmyMfBSL https://t.co/hW7Jq1mhdo

2022-11-16 01:17:21 RT @PeterHotez: Important and well-conducted study by @EricTopol My take: even though rebound is real and significant, in my conversation…

2022-11-15 23:33:25 For the people pointing out that @POTUS, @CDCDirector and Tony Fauci all had Paxlovid rebound, that's why you do prospective, systematic studies. We've learned that "rebound" also occurs without Paxlovid and that anecdotes/twitter are not representative of the real world

2022-11-15 20:14:34 Each participant did rapid antigen testing every other day through day 15, symptom surveys through day 17, and are being followed for 6 months https://t.co/8bDtswdytR

2022-11-15 20:00:32 The event curves for Paxlovid treated compared with controls https://t.co/2ykeOuBUAX

2022-11-15 19:56:25 Our prospective Paxlovid rebound study with controls preprint is posted By symptoms: ~12% rebound (19% Pax vs 7% controls) By positive testing: ~5% rebound (14% Pax vs 9% controls) Much lower than many estimates https://t.co/czeGEYIJvA by @JayPandit @michaelmina_lab @ScrippsRTI

2022-11-15 19:45:43 Foundation #AI models come to science https://t.co/G7Xx31w1Of https://t.co/HNjVOs3J4I

2022-11-15 19:23:17 @Jdrodric12 that's right!

2022-11-15 18:47:56 @SarahWLaurence @ScrippsRTI Thank you!

2022-11-15 18:31:49 On a day when the world has reached about ~8 billion people, it's notable there have been >

2022-11-15 17:10:19 @surrogateexpare @Medscape Included here https://t.co/bugfFk44sh@Medscape Please fix the links

2022-11-15 17:09:38 This post has all the relevant links and review the recent its for protection vs #LongCovid https://t.co/bugfFk44sh

2022-11-15 16:30:20 Paxlovid interactionsA new report claims 14.6% of patients had contraindications to treatment. But most of these meds could have been safely stopped for 5 dayshttps://t.co/FP3o0J0eBzMore on this herehttps://t.co/i3pUyAJlAs @Medscape https://t.co/0tsAf3xUqu

2022-11-15 16:11:35 Start of new waves in South Korea and Japan, having sustained recent BA.5 waves and this variant still accounts for most new casesThe pandemic isn't over https://t.co/DhwWhZ4CJi

2022-11-15 16:01:28 Here's the article. A potential path to preventing brain tissue from dying https://t.co/ODGuD8X8iy

2022-11-15 00:48:03 Today's pandemic briefing on new booster data and the thick soup of new variantshttps://t.co/LA3nl6FxSx

2022-11-14 17:22:13 RT @danrdanny: Excited to see our work on 3-hour genome sequencing highlighted here! If you think this is interesting we have a bench scien…

2022-11-14 17:04:44 The potential for detecting heart dysfunction (ejection fraction <

2022-11-14 14:37:14 RT @EricTopol: Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so m…

2022-11-14 14:28:16 In aggregate, solid evidence that the bivalent booster elicits a strong and broadened neutralizing antibody immune response. Yet, less than 27% of Americans 65+, the have had it and poor uptake across all age groupshttps://t.co/V5Xlj3cKln

2022-11-14 14:28:15 https://t.co/fJbLUdcYJdCoverage @statnews by @matthewherper w/ @SutharLab, whose results were replicated by the new data (Table)

2022-11-14 12:00:01 Moderna BA.5 bivalent booster results announced (via @moderna_tx press release)—largest study to date of >

2022-11-19 00:57:34 This poses a major concern for immunocompromised who have benefited from Evusheld (preventive) &

2022-11-19 00:57:33 The BQ.1.1 variant, as compared with many of the other new variants, is resistant to all clinically used monoclonal antibodies. BQ.1/BQ.1.1 are now the dominant variants in the United States https://t.co/PCFPSGF2uy @TheLancetInfDis https://t.co/dHucxoGokC

2022-11-18 21:17:45 Good news: 1st drug to alter the course of Type 1 diabetes in 100 years approved by @US_FDA Bad news: it costs ~$200,000/14-day treatment

2022-11-18 20:40:04 @legalnomads BA.1 bivalent induces about half as much neutralizing antibodies vs BA.5 as the BA.5 bivalent (live virus assays), both better than original booster. Whether that translates to any difference clinically is unclear.

2022-11-18 20:12:01 The bivalent BA.1 booster is being use in many countries around the world, but data are limited compared with the original (WT) booster against BA.5. New today: doubling of neutralizing antibodies https://t.co/M2YUB5wpH4 (BA.5 bivalent was ~3-5X WT in several recent studies) https://t.co/xYwnfcXkm6

2022-11-18 18:44:04 How to improve science discovery and productivity? Not just about money (see graph below): funding fast, bets on talent/people, take risk, think big https://t.co/HEAXu2L87H by @greg_ip w/ @patrickc @tylercowen @pdhsu https://t.co/7O6qplOf9C

2022-11-18 18:01:46 @KMunoz46 Correct. That's why there's no good explanation

2022-11-18 17:44:15 RT @ElinSilveous: “Foreign rivals have raced ahead in approving long-awaited nasal-spray vaccines, including one invented in St. Louis, cre…

2022-11-18 17:27:39 Does going to @NFL games increase risk of Covid? https://t.co/UzghLiDCgT Interesting findings of an association in the 14-21 day postgame period when >

2022-11-18 16:57:29 If you'd like to boost your protection vs BQ.1.1, 2 new studies that back up the bivalent as the way to get that done https://t.co/wAoTyur6be https://t.co/fDF4KEyJAL https://t.co/FiBnQRxlMG

2022-11-18 16:52:03 US Covid genomics

2022-11-18 15:54:32 A systematic review of Covid vaccines for kids age 5 to 11 (30 studies) Effectiveness 75% vs hospitalization

2022-11-18 15:45:27 @TopherSpiro46 @AshishKJha46 I know, Topher. Absolutely no reason for refusal of Congress and failure to fund. Appreciate @ashishkjha's strong advocacy

2022-11-18 14:58:07 An explainer for why the US is not pursuing nasal vaccines. TLDR: there is no good explanation https://t.co/Ih6ypzOva7 by @benjmueller w/ @VirusesImmunity @florian_krammer

2022-11-18 05:38:35 @hola_jonathan Many thanks!

2022-11-18 05:37:46 @amuendelheim Thanks!

2022-11-18 05:10:48 I'll be here until the lights go out........ You can also find me @erictopol@mstdn.social and https://t.co/YllXWa0b4k https://t.co/5rfMlDkCdM

2022-11-18 03:51:13 @lainemartin1 Very appreciative of your note!

2022-11-18 03:33:22 Refers to BQ.1.1 (see blue arrow)

2022-11-18 03:32:12 New data for why a bivalent booster will help: "These data suggest the bivalent BA.4/5 vaccine is more immunogenic than the original ...vaccine against circulating Omicron sublineages, including BQ.1.1 that is becoming prevalent globally." https://t.co/wAoTyur6be Get boosted! https://t.co/j21g0bELIp

2022-11-18 00:42:08 By current variant growth advantage patterns, the next couple of months in the US will be BQ.1.x dominated. Bivalent boosters will help protect

2022-11-18 00:20:49 @WHCOS Nicely put, Ron. Thanks!

2022-11-18 00:20:19 RT @WHCOS: In simpler terms: Go get your new COVID vaccination now.

2022-11-18 00:06:48 What science forgot during the pandemic https://t.co/12ffbs3ZOF by @richardhorton1 @TheLancet https://t.co/aoJSA3dEco

2022-11-17 23:56:45 A new report confirms the immune escape of the BQ.1.1 variant, along with BA.4.6 &

2022-11-17 23:26:54 We still don't have a way to diagnosis chronic traumatic encephalopathy (CTE) in people who are alive, but may be getting closer https://t.co/SftRQR7TWD by @el_belson @NYTSports https://t.co/BTh6oXUxRg

2022-11-17 21:47:06 RT @rowlsmanthorpe: Long covid has wrecked my life It’s bad, very bad. But you knew that already I want to tell you a hopeful story. A st…

2022-11-17 19:37:27 @PraliNoisette I don't see any sign of that https://t.co/e7u7aZCfBZ

2022-11-17 19:12:51 To note https://t.co/y2qdjFrvDR

2022-11-17 19:11:30 75 years later we have chips with >

2022-11-17 18:08:47 BA.5, déjà vu https://t.co/eILO8PxIkY

2022-11-17 17:33:41 RT @linseymarr: You get a 2-for-1 with filtration. It removes virus from the air and PM2.5 that is associated with an increased risk of inf…

2022-11-17 17:28:45 RT @Aiims1742: Important #OpenAccess paper in @Cancer_Cell from @CharlesSwanton &

2022-11-17 17:09:54 Strong evidence that particulate matter air pollution (ambient PM2.5) increases the risk of Covid infection, a systematic analysis https://t.co/RueG44Hk2m @MonashUni https://t.co/kpREoqJVPi

2022-11-17 15:46:50 About 1 in 5 of us have an APOE4 gene variant, the #1 genetic risk factor for Alzheimer's disease. But the mechanism for brain injury was a mystery, now getting unraveled (cholesterol processing by oligodendrocytes) https://t.co/gIpGt0CA28 @nature https://t.co/hbmdpO6R3t https://t.co/4zFZIhUTCI

2022-11-17 01:27:50 @amitsurg Because they do. That's mostly related to the excess of rebound after Paxlovid

2022-11-17 00:58:05 We've (re-)learned a few important lessons from the Paxlovid rebound experience about randomized trials and real world evidence Reviewed here https://t.co/jmT9vIipg9

2022-11-16 19:46:41 The Paxlovid rebound story New data reviewed in the 16 November daily briefing of Ground Truths https://t.co/jmT9vIipg9

2022-11-16 17:48:15 The US Covid death rate (7-day average) drops below 300 for the first time since June 2022. Lowest since pandemic began was 222 in July 2021. https://t.co/Cze8bZgtVr https://t.co/uxGosRY1KO

2022-11-16 17:14:12 Immunotherapy can induce myocarditis but the mechanism has been poorly understood. A new report @nature today supports the culprit auto-antigen role of α-myosin and cytotoxic T-cells directed to it https://t.co/uPRUQBbkVh by @MargaretAxelrod @BalkoLab https://t.co/vWZP1IcW19

2022-11-16 16:37:07 Humidity (indoor, relative) is associated with outcomes of Covid infections, a population-based study in 121 countries https://t.co/dWMmyMfBSL https://t.co/hW7Jq1mhdo

2022-11-16 01:17:21 RT @PeterHotez: Important and well-conducted study by @EricTopol My take: even though rebound is real and significant, in my conversation…

2022-11-15 23:33:25 For the people pointing out that @POTUS, @CDCDirector and Tony Fauci all had Paxlovid rebound, that's why you do prospective, systematic studies. We've learned that "rebound" also occurs without Paxlovid and that anecdotes/twitter are not representative of the real world

2022-11-15 20:14:34 Each participant did rapid antigen testing every other day through day 15, symptom surveys through day 17, and are being followed for 6 months https://t.co/8bDtswdytR

2022-11-15 20:00:32 The event curves for Paxlovid treated compared with controls https://t.co/2ykeOuBUAX

2022-11-15 19:56:25 Our prospective Paxlovid rebound study with controls preprint is posted By symptoms: ~12% rebound (19% Pax vs 7% controls) By positive testing: ~5% rebound (14% Pax vs 9% controls) Much lower than many estimates https://t.co/czeGEYIJvA by @JayPandit @michaelmina_lab @ScrippsRTI

2022-11-15 19:45:43 Foundation #AI models come to science https://t.co/G7Xx31w1Of https://t.co/HNjVOs3J4I

2022-11-15 19:23:17 @Jdrodric12 that's right!

2022-11-15 18:47:56 @SarahWLaurence @ScrippsRTI Thank you!

2022-11-15 18:31:49 On a day when the world has reached about ~8 billion people, it's notable there have been >

2022-11-15 17:10:19 @surrogateexpare @Medscape Included here https://t.co/bugfFk44sh@Medscape Please fix the links

2022-11-15 17:09:38 This post has all the relevant links and review the recent its for protection vs #LongCovid https://t.co/bugfFk44sh

2022-11-15 16:30:20 Paxlovid interactionsA new report claims 14.6% of patients had contraindications to treatment. But most of these meds could have been safely stopped for 5 dayshttps://t.co/FP3o0J0eBzMore on this herehttps://t.co/i3pUyAJlAs @Medscape https://t.co/0tsAf3xUqu

2022-11-15 16:11:35 Start of new waves in South Korea and Japan, having sustained recent BA.5 waves and this variant still accounts for most new casesThe pandemic isn't over https://t.co/DhwWhZ4CJi

2022-11-15 16:01:28 Here's the article. A potential path to preventing brain tissue from dying https://t.co/ODGuD8X8iy

2022-11-15 00:48:03 Today's pandemic briefing on new booster data and the thick soup of new variantshttps://t.co/LA3nl6FxSx

2022-11-14 17:22:13 RT @danrdanny: Excited to see our work on 3-hour genome sequencing highlighted here! If you think this is interesting we have a bench scien…

2022-11-14 17:04:44 The potential for detecting heart dysfunction (ejection fraction <

2022-11-14 14:37:14 RT @EricTopol: Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so m…

2022-11-14 14:28:16 In aggregate, solid evidence that the bivalent booster elicits a strong and broadened neutralizing antibody immune response. Yet, less than 27% of Americans 65+, the have had it and poor uptake across all age groupshttps://t.co/V5Xlj3cKln

2022-11-14 14:28:15 https://t.co/fJbLUdcYJdCoverage @statnews by @matthewherper w/ @SutharLab, whose results were replicated by the new data (Table)

2022-11-14 12:00:01 Moderna BA.5 bivalent booster results announced (via @moderna_tx press release)—largest study to date of >

2022-11-19 20:21:41 A new and useful perspective on this report @NatRevNeurol https://t.co/wZ9kvh567Q by @alessandro5161 and @andreapilotto https://t.co/cjturtGVq2

2022-11-19 20:00:42 @TheLarvinMewis Thank you!

2022-11-19 19:46:26 My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SARSCoV2 variant with a marked increase in immune evasion not to have induced a wave. https://t.co/DqMJ7LAALu

2022-11-19 15:35:10 Correcting my typo: it's ronna, not rona More on this here @nature by @LizzieGibney https://t.co/Erb4zTYWCl https://t.co/zMGRoGHeTk

2022-11-19 15:20:02 I thought that many bytes should be named helluva but the new name is quetta https://t.co/d77lA6LTc2

2022-11-19 00:57:34 This poses a major concern for immunocompromised who have benefited from Evusheld (preventive) &

2022-11-19 00:57:33 The BQ.1.1 variant, as compared with many of the other new variants, is resistant to all clinically used monoclonal antibodies. BQ.1/BQ.1.1 are now the dominant variants in the United States https://t.co/PCFPSGF2uy @TheLancetInfDis https://t.co/dHucxoGokC

2022-11-18 21:17:45 Good news: 1st drug to alter the course of Type 1 diabetes in 100 years approved by @US_FDA Bad news: it costs ~$200,000/14-day treatment

2022-11-18 20:40:04 @legalnomads BA.1 bivalent induces about half as much neutralizing antibodies vs BA.5 as the BA.5 bivalent (live virus assays), both better than original booster. Whether that translates to any difference clinically is unclear.

2022-11-18 20:12:01 The bivalent BA.1 booster is being use in many countries around the world, but data are limited compared with the original (WT) booster against BA.5. New today: doubling of neutralizing antibodies https://t.co/M2YUB5wpH4 (BA.5 bivalent was ~3-5X WT in several recent studies) https://t.co/xYwnfcXkm6

2022-11-18 18:44:04 How to improve science discovery and productivity? Not just about money (see graph below): funding fast, bets on talent/people, take risk, think big https://t.co/HEAXu2L87H by @greg_ip w/ @patrickc @tylercowen @pdhsu https://t.co/7O6qplOf9C

2022-11-18 18:01:46 @KMunoz46 Correct. That's why there's no good explanation

2022-11-18 17:44:15 RT @ElinSilveous: “Foreign rivals have raced ahead in approving long-awaited nasal-spray vaccines, including one invented in St. Louis, cre…

2022-11-18 17:27:39 Does going to @NFL games increase risk of Covid? https://t.co/UzghLiDCgT Interesting findings of an association in the 14-21 day postgame period when >

2022-11-18 16:57:29 If you'd like to boost your protection vs BQ.1.1, 2 new studies that back up the bivalent as the way to get that done https://t.co/wAoTyur6be https://t.co/fDF4KEyJAL https://t.co/FiBnQRxlMG

2022-11-18 16:52:03 US Covid genomics

2022-11-18 15:54:32 A systematic review of Covid vaccines for kids age 5 to 11 (30 studies) Effectiveness 75% vs hospitalization

2022-11-18 15:45:27 @TopherSpiro46 @AshishKJha46 I know, Topher. Absolutely no reason for refusal of Congress and failure to fund. Appreciate @ashishkjha's strong advocacy

2022-11-18 14:58:07 An explainer for why the US is not pursuing nasal vaccines. TLDR: there is no good explanation https://t.co/Ih6ypzOva7 by @benjmueller w/ @VirusesImmunity @florian_krammer

2022-11-18 05:38:35 @hola_jonathan Many thanks!

2022-11-18 05:37:46 @amuendelheim Thanks!

2022-11-18 05:10:48 I'll be here until the lights go out........ You can also find me @erictopol@mstdn.social and https://t.co/YllXWa0b4k https://t.co/5rfMlDkCdM

2022-11-18 03:51:13 @lainemartin1 Very appreciative of your note!

2022-11-18 03:33:22 Refers to BQ.1.1 (see blue arrow)

2022-11-18 03:32:12 New data for why a bivalent booster will help: "These data suggest the bivalent BA.4/5 vaccine is more immunogenic than the original ...vaccine against circulating Omicron sublineages, including BQ.1.1 that is becoming prevalent globally." https://t.co/wAoTyur6be Get boosted! https://t.co/j21g0bELIp

2022-11-18 00:42:08 By current variant growth advantage patterns, the next couple of months in the US will be BQ.1.x dominated. Bivalent boosters will help protect

2022-11-18 00:20:49 @WHCOS Nicely put, Ron. Thanks!

2022-11-18 00:20:19 RT @WHCOS: In simpler terms: Go get your new COVID vaccination now.

2022-11-18 00:06:48 What science forgot during the pandemic https://t.co/12ffbs3ZOF by @richardhorton1 @TheLancet https://t.co/aoJSA3dEco

2022-11-17 23:56:45 A new report confirms the immune escape of the BQ.1.1 variant, along with BA.4.6 &

2022-11-17 23:26:54 We still don't have a way to diagnosis chronic traumatic encephalopathy (CTE) in people who are alive, but may be getting closer https://t.co/SftRQR7TWD by @el_belson @NYTSports https://t.co/BTh6oXUxRg

2022-11-17 21:47:06 RT @rowlsmanthorpe: Long covid has wrecked my life It’s bad, very bad. But you knew that already I want to tell you a hopeful story. A st…

2022-11-17 19:37:27 @PraliNoisette I don't see any sign of that https://t.co/e7u7aZCfBZ

2022-11-17 19:12:51 To note https://t.co/y2qdjFrvDR

2022-11-17 19:11:30 75 years later we have chips with >

2022-11-17 18:08:47 BA.5, déjà vu https://t.co/eILO8PxIkY

2022-11-17 17:33:41 RT @linseymarr: You get a 2-for-1 with filtration. It removes virus from the air and PM2.5 that is associated with an increased risk of inf…

2022-11-17 17:28:45 RT @Aiims1742: Important #OpenAccess paper in @Cancer_Cell from @CharlesSwanton &

2022-11-17 17:09:54 Strong evidence that particulate matter air pollution (ambient PM2.5) increases the risk of Covid infection, a systematic analysis https://t.co/RueG44Hk2m @MonashUni https://t.co/kpREoqJVPi

2022-11-17 15:46:50 About 1 in 5 of us have an APOE4 gene variant, the #1 genetic risk factor for Alzheimer's disease. But the mechanism for brain injury was a mystery, now getting unraveled (cholesterol processing by oligodendrocytes) https://t.co/gIpGt0CA28 @nature https://t.co/hbmdpO6R3t https://t.co/4zFZIhUTCI

2022-11-17 01:27:50 @amitsurg Because they do. That's mostly related to the excess of rebound after Paxlovid

2022-11-17 00:58:05 We've (re-)learned a few important lessons from the Paxlovid rebound experience about randomized trials and real world evidence Reviewed here https://t.co/jmT9vIipg9

2022-11-16 19:46:41 The Paxlovid rebound story New data reviewed in the 16 November daily briefing of Ground Truths https://t.co/jmT9vIipg9

2022-11-16 17:48:15 The US Covid death rate (7-day average) drops below 300 for the first time since June 2022. Lowest since pandemic began was 222 in July 2021. https://t.co/Cze8bZgtVr https://t.co/uxGosRY1KO

2022-11-16 17:14:12 Immunotherapy can induce myocarditis but the mechanism has been poorly understood. A new report @nature today supports the culprit auto-antigen role of α-myosin and cytotoxic T-cells directed to it https://t.co/uPRUQBbkVh by @MargaretAxelrod @BalkoLab https://t.co/vWZP1IcW19

2022-11-16 16:37:07 Humidity (indoor, relative) is associated with outcomes of Covid infections, a population-based study in 121 countries https://t.co/dWMmyMfBSL https://t.co/hW7Jq1mhdo

2022-11-16 01:17:21 RT @PeterHotez: Important and well-conducted study by @EricTopol My take: even though rebound is real and significant, in my conversation…

2022-11-15 23:33:25 For the people pointing out that @POTUS, @CDCDirector and Tony Fauci all had Paxlovid rebound, that's why you do prospective, systematic studies. We've learned that "rebound" also occurs without Paxlovid and that anecdotes/twitter are not representative of the real world

2022-11-15 20:14:34 Each participant did rapid antigen testing every other day through day 15, symptom surveys through day 17, and are being followed for 6 months https://t.co/8bDtswdytR

2022-11-15 20:00:32 The event curves for Paxlovid treated compared with controls https://t.co/2ykeOuBUAX

2022-11-15 19:56:25 Our prospective Paxlovid rebound study with controls preprint is posted By symptoms: ~12% rebound (19% Pax vs 7% controls) By positive testing: ~5% rebound (14% Pax vs 9% controls) Much lower than many estimates https://t.co/czeGEYIJvA by @JayPandit @michaelmina_lab @ScrippsRTI

2022-11-15 19:45:43 Foundation #AI models come to science https://t.co/G7Xx31w1Of https://t.co/HNjVOs3J4I

2022-11-15 19:23:17 @Jdrodric12 that's right!

2022-11-15 18:47:56 @SarahWLaurence @ScrippsRTI Thank you!

2022-11-15 18:31:49 On a day when the world has reached about ~8 billion people, it's notable there have been >

2022-11-15 17:10:19 @surrogateexpare @Medscape Included here https://t.co/bugfFk44sh@Medscape Please fix the links

2022-11-15 17:09:38 This post has all the relevant links and review the recent its for protection vs #LongCovid https://t.co/bugfFk44sh

2022-11-15 16:30:20 Paxlovid interactionsA new report claims 14.6% of patients had contraindications to treatment. But most of these meds could have been safely stopped for 5 dayshttps://t.co/FP3o0J0eBzMore on this herehttps://t.co/i3pUyAJlAs @Medscape https://t.co/0tsAf3xUqu

2022-11-15 16:11:35 Start of new waves in South Korea and Japan, having sustained recent BA.5 waves and this variant still accounts for most new casesThe pandemic isn't over https://t.co/DhwWhZ4CJi

2022-11-15 16:01:28 Here's the article. A potential path to preventing brain tissue from dying https://t.co/ODGuD8X8iy

2022-11-15 00:48:03 Today's pandemic briefing on new booster data and the thick soup of new variantshttps://t.co/LA3nl6FxSx

2022-11-14 17:22:13 RT @danrdanny: Excited to see our work on 3-hour genome sequencing highlighted here! If you think this is interesting we have a bench scien…

2022-11-14 17:04:44 The potential for detecting heart dysfunction (ejection fraction <

2022-11-14 14:37:14 RT @EricTopol: Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so m…

2022-11-14 14:28:16 In aggregate, solid evidence that the bivalent booster elicits a strong and broadened neutralizing antibody immune response. Yet, less than 27% of Americans 65+, the have had it and poor uptake across all age groupshttps://t.co/V5Xlj3cKln

2022-11-14 14:28:15 https://t.co/fJbLUdcYJdCoverage @statnews by @matthewherper w/ @SutharLab, whose results were replicated by the new data (Table)

2022-11-14 12:00:01 Moderna BA.5 bivalent booster results announced (via @moderna_tx press release)—largest study to date of >

2022-11-21 03:25:03 @kjhyuijhybh Yes I did that https://t.co/mJyBxYKymV

2022-11-21 03:24:06 @fstults2 https://t.co/mJyBxZ1BoV works

2022-11-21 01:21:26 Tumors also can have fungi within them which can, like (and interact with) bacteria, have functional impact on cancer and its therapy https://t.co/KDWV9XjQzW @CellCellPress https://t.co/72eyqbrMq0

2022-11-21 00:03:11 @steveagee Approved in China, India, Iran Big clinical trial in Mexico A company (Ocugen) has licensed the Bharat Biotech (India, IP from @WUSTL) for the United States but there’s no regulatory guidance by @US_FDA yet for Covid nasal vaccines

2022-11-20 23:46:08 RT @EricTopol: My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SAR…

2022-11-20 23:14:08 @kellyclose Both, Kelly. T1D mostly in young, predominantly T2D overall

2022-11-20 22:12:36 Great to see a big win for @UVA @UVAMensHoops

2022-11-20 19:10:31 https://t.co/N60zU6pExk

2022-11-20 19:10:30 Bacteria within tumors are capable of suppressing the immune response and promoting cancer spread https://t.co/g0WfQOd6lA @nature elegant work by @BullmanLab and @CJohnstonLab1 using spatial genomics https://t.co/K1sAMmpvhS https://t.co/C62S0nwLFR

2022-11-20 18:55:24 The consistent increased risk of diabetes after Covid across all age groups, highest in the first 3 months after infection, from a systematic review of 9 studies, ~40 million people https://t.co/uJ5T3ENGrj https://t.co/GZzZmhDrfH

2022-11-20 18:41:40 No need to dream anymore. This can be done. But it takes will, priority and funding And debunking the delusion that we're done with #SARSCoV2 https://t.co/TrR777xZTI https://t.co/eKHGg7EPtM https://t.co/1ijx5gN79W

2022-11-20 17:54:58 Months ago @VirusesImmunity and I laid out the strong case for nasal vaccines to achieve containment of the virus, breaking the chain of transmission at the individual and population level https://t.co/OujfFxMgU6 @SciImmunology https://t.co/lPGQTC2T1i

2022-11-20 16:23:27 I'm outraged by this pathetic and inexcusable inability for this country to go after nasal and better, durable, variant-proof vaccines https://t.co/u2AErUyYpN https://t.co/CuRQ51q8pi

2022-11-20 16:10:23 The variants accounting for new cases in Japan as of 11 November https://t.co/Tkkh0fwsf9 https://t.co/2JPHxUOxG1

2022-11-20 15:58:24 There's a 2nd BA.5 wave happening in Japan, the country that has best managed the pandemic https://t.co/z68bDAyl3a https://t.co/FTGx5BB1qt

2022-11-20 15:45:21 Why is the outlook favorable when new variants with marked immune evasion and growth advantage have become dominant? https://t.co/DqMJ7LSJZC

2022-11-19 20:21:41 A new and useful perspective on this report @NatRevNeurol https://t.co/wZ9kvh567Q by @alessandro5161 and @andreapilotto https://t.co/cjturtGVq2

2022-11-19 20:00:42 @TheLarvinMewis Thank you!

2022-11-19 19:46:26 My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SARSCoV2 variant with a marked increase in immune evasion not to have induced a wave. https://t.co/DqMJ7LAALu

2022-11-19 15:35:10 Correcting my typo: it's ronna, not rona More on this here @nature by @LizzieGibney https://t.co/Erb4zTYWCl https://t.co/zMGRoGHeTk

2022-11-19 15:20:02 I thought that many bytes should be named helluva but the new name is quetta https://t.co/d77lA6LTc2

2022-11-19 00:57:34 This poses a major concern for immunocompromised who have benefited from Evusheld (preventive) &

2022-11-19 00:57:33 The BQ.1.1 variant, as compared with many of the other new variants, is resistant to all clinically used monoclonal antibodies. BQ.1/BQ.1.1 are now the dominant variants in the United States https://t.co/PCFPSGF2uy @TheLancetInfDis https://t.co/dHucxoGokC

2022-11-18 21:17:45 Good news: 1st drug to alter the course of Type 1 diabetes in 100 years approved by @US_FDA Bad news: it costs ~$200,000/14-day treatment

2022-11-18 20:40:04 @legalnomads BA.1 bivalent induces about half as much neutralizing antibodies vs BA.5 as the BA.5 bivalent (live virus assays), both better than original booster. Whether that translates to any difference clinically is unclear.

2022-11-18 20:12:01 The bivalent BA.1 booster is being use in many countries around the world, but data are limited compared with the original (WT) booster against BA.5. New today: doubling of neutralizing antibodies https://t.co/M2YUB5wpH4 (BA.5 bivalent was ~3-5X WT in several recent studies) https://t.co/xYwnfcXkm6

2022-11-18 18:44:04 How to improve science discovery and productivity? Not just about money (see graph below): funding fast, bets on talent/people, take risk, think big https://t.co/HEAXu2L87H by @greg_ip w/ @patrickc @tylercowen @pdhsu https://t.co/7O6qplOf9C

2022-11-18 18:01:46 @KMunoz46 Correct. That's why there's no good explanation

2022-11-18 17:44:15 RT @ElinSilveous: “Foreign rivals have raced ahead in approving long-awaited nasal-spray vaccines, including one invented in St. Louis, cre…

2022-11-18 17:27:39 Does going to @NFL games increase risk of Covid? https://t.co/UzghLiDCgT Interesting findings of an association in the 14-21 day postgame period when >

2022-11-18 16:57:29 If you'd like to boost your protection vs BQ.1.1, 2 new studies that back up the bivalent as the way to get that done https://t.co/wAoTyur6be https://t.co/fDF4KEyJAL https://t.co/FiBnQRxlMG

2022-11-18 16:52:03 US Covid genomics

2022-11-18 15:54:32 A systematic review of Covid vaccines for kids age 5 to 11 (30 studies) Effectiveness 75% vs hospitalization

2022-11-18 15:45:27 @TopherSpiro46 @AshishKJha46 I know, Topher. Absolutely no reason for refusal of Congress and failure to fund. Appreciate @ashishkjha's strong advocacy

2022-11-18 14:58:07 An explainer for why the US is not pursuing nasal vaccines. TLDR: there is no good explanation https://t.co/Ih6ypzOva7 by @benjmueller w/ @VirusesImmunity @florian_krammer

2022-11-18 05:38:35 @hola_jonathan Many thanks!

2022-11-18 05:37:46 @amuendelheim Thanks!

2022-11-18 05:10:48 I'll be here until the lights go out........ You can also find me @erictopol@mstdn.social and https://t.co/YllXWa0b4k https://t.co/5rfMlDkCdM

2022-11-18 03:51:13 @lainemartin1 Very appreciative of your note!

2022-11-18 03:33:22 Refers to BQ.1.1 (see blue arrow)

2022-11-18 03:32:12 New data for why a bivalent booster will help: "These data suggest the bivalent BA.4/5 vaccine is more immunogenic than the original ...vaccine against circulating Omicron sublineages, including BQ.1.1 that is becoming prevalent globally." https://t.co/wAoTyur6be Get boosted! https://t.co/j21g0bELIp

2022-11-18 00:42:08 By current variant growth advantage patterns, the next couple of months in the US will be BQ.1.x dominated. Bivalent boosters will help protect

2022-11-18 00:20:49 @WHCOS Nicely put, Ron. Thanks!

2022-11-18 00:20:19 RT @WHCOS: In simpler terms: Go get your new COVID vaccination now.

2022-11-18 00:06:48 What science forgot during the pandemic https://t.co/12ffbs3ZOF by @richardhorton1 @TheLancet https://t.co/aoJSA3dEco

2022-11-17 23:56:45 A new report confirms the immune escape of the BQ.1.1 variant, along with BA.4.6 &

2022-11-17 23:26:54 We still don't have a way to diagnosis chronic traumatic encephalopathy (CTE) in people who are alive, but may be getting closer https://t.co/SftRQR7TWD by @el_belson @NYTSports https://t.co/BTh6oXUxRg

2022-11-17 21:47:06 RT @rowlsmanthorpe: Long covid has wrecked my life It’s bad, very bad. But you knew that already I want to tell you a hopeful story. A st…

2022-11-17 19:37:27 @PraliNoisette I don't see any sign of that https://t.co/e7u7aZCfBZ

2022-11-17 19:12:51 To note https://t.co/y2qdjFrvDR

2022-11-17 19:11:30 75 years later we have chips with >

2022-11-17 18:08:47 BA.5, déjà vu https://t.co/eILO8PxIkY

2022-11-17 17:33:41 RT @linseymarr: You get a 2-for-1 with filtration. It removes virus from the air and PM2.5 that is associated with an increased risk of inf…

2022-11-17 17:28:45 RT @Aiims1742: Important #OpenAccess paper in @Cancer_Cell from @CharlesSwanton &

2022-11-17 17:09:54 Strong evidence that particulate matter air pollution (ambient PM2.5) increases the risk of Covid infection, a systematic analysis https://t.co/RueG44Hk2m @MonashUni https://t.co/kpREoqJVPi

2022-11-17 15:46:50 About 1 in 5 of us have an APOE4 gene variant, the #1 genetic risk factor for Alzheimer's disease. But the mechanism for brain injury was a mystery, now getting unraveled (cholesterol processing by oligodendrocytes) https://t.co/gIpGt0CA28 @nature https://t.co/hbmdpO6R3t https://t.co/4zFZIhUTCI

2022-11-17 01:27:50 @amitsurg Because they do. That's mostly related to the excess of rebound after Paxlovid

2022-11-17 00:58:05 We've (re-)learned a few important lessons from the Paxlovid rebound experience about randomized trials and real world evidence Reviewed here https://t.co/jmT9vIipg9

2022-11-16 19:46:41 The Paxlovid rebound story New data reviewed in the 16 November daily briefing of Ground Truths https://t.co/jmT9vIipg9

2022-11-16 17:48:15 The US Covid death rate (7-day average) drops below 300 for the first time since June 2022. Lowest since pandemic began was 222 in July 2021. https://t.co/Cze8bZgtVr https://t.co/uxGosRY1KO

2022-11-16 17:14:12 Immunotherapy can induce myocarditis but the mechanism has been poorly understood. A new report @nature today supports the culprit auto-antigen role of α-myosin and cytotoxic T-cells directed to it https://t.co/uPRUQBbkVh by @MargaretAxelrod @BalkoLab https://t.co/vWZP1IcW19

2022-11-16 16:37:07 Humidity (indoor, relative) is associated with outcomes of Covid infections, a population-based study in 121 countries https://t.co/dWMmyMfBSL https://t.co/hW7Jq1mhdo

2022-11-16 01:17:21 RT @PeterHotez: Important and well-conducted study by @EricTopol My take: even though rebound is real and significant, in my conversation…

2022-11-15 23:33:25 For the people pointing out that @POTUS, @CDCDirector and Tony Fauci all had Paxlovid rebound, that's why you do prospective, systematic studies. We've learned that "rebound" also occurs without Paxlovid and that anecdotes/twitter are not representative of the real world

2022-11-15 20:14:34 Each participant did rapid antigen testing every other day through day 15, symptom surveys through day 17, and are being followed for 6 months https://t.co/8bDtswdytR

2022-11-15 20:00:32 The event curves for Paxlovid treated compared with controls https://t.co/2ykeOuBUAX

2022-11-15 19:56:25 Our prospective Paxlovid rebound study with controls preprint is posted By symptoms: ~12% rebound (19% Pax vs 7% controls) By positive testing: ~5% rebound (14% Pax vs 9% controls) Much lower than many estimates https://t.co/czeGEYIJvA by @JayPandit @michaelmina_lab @ScrippsRTI

2022-11-15 19:45:43 Foundation #AI models come to science https://t.co/G7Xx31w1Of https://t.co/HNjVOs3J4I

2022-11-15 19:23:17 @Jdrodric12 that's right!

2022-11-15 18:47:56 @SarahWLaurence @ScrippsRTI Thank you!

2022-11-15 18:31:49 On a day when the world has reached about ~8 billion people, it's notable there have been >

2022-11-15 17:10:19 @surrogateexpare @Medscape Included here https://t.co/bugfFk44sh@Medscape Please fix the links

2022-11-15 17:09:38 This post has all the relevant links and review the recent its for protection vs #LongCovid https://t.co/bugfFk44sh

2022-11-15 16:30:20 Paxlovid interactionsA new report claims 14.6% of patients had contraindications to treatment. But most of these meds could have been safely stopped for 5 dayshttps://t.co/FP3o0J0eBzMore on this herehttps://t.co/i3pUyAJlAs @Medscape https://t.co/0tsAf3xUqu

2022-11-15 16:11:35 Start of new waves in South Korea and Japan, having sustained recent BA.5 waves and this variant still accounts for most new casesThe pandemic isn't over https://t.co/DhwWhZ4CJi

2022-11-15 16:01:28 Here's the article. A potential path to preventing brain tissue from dying https://t.co/ODGuD8X8iy

2022-11-15 00:48:03 Today's pandemic briefing on new booster data and the thick soup of new variantshttps://t.co/LA3nl6FxSx

2022-11-14 17:22:13 RT @danrdanny: Excited to see our work on 3-hour genome sequencing highlighted here! If you think this is interesting we have a bench scien…

2022-11-14 17:04:44 The potential for detecting heart dysfunction (ejection fraction <

2022-11-14 14:37:14 RT @EricTopol: Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so m…

2022-11-14 14:28:16 In aggregate, solid evidence that the bivalent booster elicits a strong and broadened neutralizing antibody immune response. Yet, less than 27% of Americans 65+, the have had it and poor uptake across all age groupshttps://t.co/V5Xlj3cKln

2022-11-14 14:28:15 https://t.co/fJbLUdcYJdCoverage @statnews by @matthewherper w/ @SutharLab, whose results were replicated by the new data (Table)

2022-11-14 12:00:01 Moderna BA.5 bivalent booster results announced (via @moderna_tx press release)—largest study to date of >

2022-11-21 16:14:51 As of 10 November 2022, it is estimated that 94% of Americans have had Covid at least once, much of those infections in the past year. Ranking of states w/ most vulnerability d/t lack of vaccines/ boosters https://t.co/W5zzyrD0vN @HarvardChanSPH https://t.co/FlY9MqC3Jq

2022-11-21 14:55:09 Unlike the prior 2 holiday seasons in the US, a major surge is unlikely, which is not in keeping with new, dominant variants with marked immune evasion. https://t.co/DqMJ7LAALu However, waning of immunity, poor uptake of boosters, and lack of mitigation sets up vulnerability https://t.co/rEQSBzeewg

2022-11-21 14:38:35 Encouraging new data for @Novavax boosters (1st and 2nd) for inducing neutralizing antibody response vs BA.5 https://t.co/CmpPueCwuG https://t.co/sbeWpljL7e

2022-11-21 14:28:55 Myocarditis after mRNA Covid vaccines: results from over 10 million doses in British Columbia https://t.co/CrnzxyPSDX @CMAJ https://t.co/y4rcdcJS67

2022-11-21 03:25:03 @kjhyuijhybh Yes I did that https://t.co/mJyBxYKymV

2022-11-21 03:24:06 @fstults2 https://t.co/mJyBxZ1BoV works

2022-11-21 01:21:26 Tumors also can have fungi within them which can, like (and interact with) bacteria, have functional impact on cancer and its therapy https://t.co/KDWV9XjQzW @CellCellPress https://t.co/72eyqbrMq0

2022-11-21 00:03:11 @steveagee Approved in China, India, Iran Big clinical trial in Mexico A company (Ocugen) has licensed the Bharat Biotech (India, IP from @WUSTL) for the United States but there’s no regulatory guidance by @US_FDA yet for Covid nasal vaccines

2022-11-20 23:46:08 RT @EricTopol: My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SAR…

2022-11-20 23:14:08 @kellyclose Both, Kelly. T1D mostly in young, predominantly T2D overall

2022-11-20 22:12:36 Great to see a big win for @UVA @UVAMensHoops

2022-11-20 19:10:31 https://t.co/N60zU6pExk

2022-11-20 19:10:30 Bacteria within tumors are capable of suppressing the immune response and promoting cancer spread https://t.co/g0WfQOd6lA @nature elegant work by @BullmanLab and @CJohnstonLab1 using spatial genomics https://t.co/K1sAMmpvhS https://t.co/C62S0nwLFR

2022-11-20 18:55:24 The consistent increased risk of diabetes after Covid across all age groups, highest in the first 3 months after infection, from a systematic review of 9 studies, ~40 million people https://t.co/uJ5T3ENGrj https://t.co/GZzZmhDrfH

2022-11-20 18:41:40 No need to dream anymore. This can be done. But it takes will, priority and funding And debunking the delusion that we're done with #SARSCoV2 https://t.co/TrR777xZTI https://t.co/eKHGg7EPtM https://t.co/1ijx5gN79W

2022-11-20 17:54:58 Months ago @VirusesImmunity and I laid out the strong case for nasal vaccines to achieve containment of the virus, breaking the chain of transmission at the individual and population level https://t.co/OujfFxMgU6 @SciImmunology https://t.co/lPGQTC2T1i

2022-11-20 16:23:27 I'm outraged by this pathetic and inexcusable inability for this country to go after nasal and better, durable, variant-proof vaccines https://t.co/u2AErUyYpN https://t.co/CuRQ51q8pi

2022-11-20 16:10:23 The variants accounting for new cases in Japan as of 11 November https://t.co/Tkkh0fwsf9 https://t.co/2JPHxUOxG1

2022-11-20 15:58:24 There's a 2nd BA.5 wave happening in Japan, the country that has best managed the pandemic https://t.co/z68bDAyl3a https://t.co/FTGx5BB1qt

2022-11-20 15:45:21 Why is the outlook favorable when new variants with marked immune evasion and growth advantage have become dominant? https://t.co/DqMJ7LSJZC

2022-11-19 20:21:41 A new and useful perspective on this report @NatRevNeurol https://t.co/wZ9kvh567Q by @alessandro5161 and @andreapilotto https://t.co/cjturtGVq2

2022-11-19 20:00:42 @TheLarvinMewis Thank you!

2022-11-19 19:46:26 My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SARSCoV2 variant with a marked increase in immune evasion not to have induced a wave. https://t.co/DqMJ7LAALu

2022-11-19 15:35:10 Correcting my typo: it's ronna, not rona More on this here @nature by @LizzieGibney https://t.co/Erb4zTYWCl https://t.co/zMGRoGHeTk

2022-11-19 15:20:02 I thought that many bytes should be named helluva but the new name is quetta https://t.co/d77lA6LTc2

2022-11-19 00:57:34 This poses a major concern for immunocompromised who have benefited from Evusheld (preventive) &

2022-11-19 00:57:33 The BQ.1.1 variant, as compared with many of the other new variants, is resistant to all clinically used monoclonal antibodies. BQ.1/BQ.1.1 are now the dominant variants in the United States https://t.co/PCFPSGF2uy @TheLancetInfDis https://t.co/dHucxoGokC

2022-11-18 21:17:45 Good news: 1st drug to alter the course of Type 1 diabetes in 100 years approved by @US_FDA Bad news: it costs ~$200,000/14-day treatment

2022-11-18 20:40:04 @legalnomads BA.1 bivalent induces about half as much neutralizing antibodies vs BA.5 as the BA.5 bivalent (live virus assays), both better than original booster. Whether that translates to any difference clinically is unclear.

2022-11-18 20:12:01 The bivalent BA.1 booster is being use in many countries around the world, but data are limited compared with the original (WT) booster against BA.5. New today: doubling of neutralizing antibodies https://t.co/M2YUB5wpH4 (BA.5 bivalent was ~3-5X WT in several recent studies) https://t.co/xYwnfcXkm6

2022-11-18 18:44:04 How to improve science discovery and productivity? Not just about money (see graph below): funding fast, bets on talent/people, take risk, think big https://t.co/HEAXu2L87H by @greg_ip w/ @patrickc @tylercowen @pdhsu https://t.co/7O6qplOf9C

2022-11-18 18:01:46 @KMunoz46 Correct. That's why there's no good explanation

2022-11-18 17:44:15 RT @ElinSilveous: “Foreign rivals have raced ahead in approving long-awaited nasal-spray vaccines, including one invented in St. Louis, cre…

2022-11-18 17:27:39 Does going to @NFL games increase risk of Covid? https://t.co/UzghLiDCgT Interesting findings of an association in the 14-21 day postgame period when >

2022-11-18 16:57:29 If you'd like to boost your protection vs BQ.1.1, 2 new studies that back up the bivalent as the way to get that done https://t.co/wAoTyur6be https://t.co/fDF4KEyJAL https://t.co/FiBnQRxlMG

2022-11-18 16:52:03 US Covid genomics

2022-11-18 15:54:32 A systematic review of Covid vaccines for kids age 5 to 11 (30 studies) Effectiveness 75% vs hospitalization

2022-11-18 15:45:27 @TopherSpiro46 @AshishKJha46 I know, Topher. Absolutely no reason for refusal of Congress and failure to fund. Appreciate @ashishkjha's strong advocacy

2022-11-18 14:58:07 An explainer for why the US is not pursuing nasal vaccines. TLDR: there is no good explanation https://t.co/Ih6ypzOva7 by @benjmueller w/ @VirusesImmunity @florian_krammer

2022-11-18 05:38:35 @hola_jonathan Many thanks!

2022-11-18 05:37:46 @amuendelheim Thanks!

2022-11-18 05:10:48 I'll be here until the lights go out........ You can also find me @erictopol@mstdn.social and https://t.co/YllXWa0b4k https://t.co/5rfMlDkCdM

2022-11-18 03:51:13 @lainemartin1 Very appreciative of your note!

2022-11-18 03:33:22 Refers to BQ.1.1 (see blue arrow)

2022-11-18 03:32:12 New data for why a bivalent booster will help: "These data suggest the bivalent BA.4/5 vaccine is more immunogenic than the original ...vaccine against circulating Omicron sublineages, including BQ.1.1 that is becoming prevalent globally." https://t.co/wAoTyur6be Get boosted! https://t.co/j21g0bELIp

2022-11-18 00:42:08 By current variant growth advantage patterns, the next couple of months in the US will be BQ.1.x dominated. Bivalent boosters will help protect

2022-11-18 00:20:49 @WHCOS Nicely put, Ron. Thanks!

2022-11-18 00:20:19 RT @WHCOS: In simpler terms: Go get your new COVID vaccination now.

2022-11-18 00:06:48 What science forgot during the pandemic https://t.co/12ffbs3ZOF by @richardhorton1 @TheLancet https://t.co/aoJSA3dEco

2022-11-17 23:56:45 A new report confirms the immune escape of the BQ.1.1 variant, along with BA.4.6 &

2022-11-17 23:26:54 We still don't have a way to diagnosis chronic traumatic encephalopathy (CTE) in people who are alive, but may be getting closer https://t.co/SftRQR7TWD by @el_belson @NYTSports https://t.co/BTh6oXUxRg

2022-11-17 21:47:06 RT @rowlsmanthorpe: Long covid has wrecked my life It’s bad, very bad. But you knew that already I want to tell you a hopeful story. A st…

2022-11-17 19:37:27 @PraliNoisette I don't see any sign of that https://t.co/e7u7aZCfBZ

2022-11-17 19:12:51 To note https://t.co/y2qdjFrvDR

2022-11-17 19:11:30 75 years later we have chips with >

2022-11-17 18:08:47 BA.5, déjà vu https://t.co/eILO8PxIkY

2022-11-17 17:33:41 RT @linseymarr: You get a 2-for-1 with filtration. It removes virus from the air and PM2.5 that is associated with an increased risk of inf…

2022-11-17 17:28:45 RT @Aiims1742: Important #OpenAccess paper in @Cancer_Cell from @CharlesSwanton &

2022-11-17 17:09:54 Strong evidence that particulate matter air pollution (ambient PM2.5) increases the risk of Covid infection, a systematic analysis https://t.co/RueG44Hk2m @MonashUni https://t.co/kpREoqJVPi

2022-11-17 15:46:50 About 1 in 5 of us have an APOE4 gene variant, the #1 genetic risk factor for Alzheimer's disease. But the mechanism for brain injury was a mystery, now getting unraveled (cholesterol processing by oligodendrocytes) https://t.co/gIpGt0CA28 @nature https://t.co/hbmdpO6R3t https://t.co/4zFZIhUTCI

2022-11-17 01:27:50 @amitsurg Because they do. That's mostly related to the excess of rebound after Paxlovid

2022-11-17 00:58:05 We've (re-)learned a few important lessons from the Paxlovid rebound experience about randomized trials and real world evidence Reviewed here https://t.co/jmT9vIipg9

2022-11-16 19:46:41 The Paxlovid rebound story New data reviewed in the 16 November daily briefing of Ground Truths https://t.co/jmT9vIipg9

2022-11-16 17:48:15 The US Covid death rate (7-day average) drops below 300 for the first time since June 2022. Lowest since pandemic began was 222 in July 2021. https://t.co/Cze8bZgtVr https://t.co/uxGosRY1KO

2022-11-16 17:14:12 Immunotherapy can induce myocarditis but the mechanism has been poorly understood. A new report @nature today supports the culprit auto-antigen role of α-myosin and cytotoxic T-cells directed to it https://t.co/uPRUQBbkVh by @MargaretAxelrod @BalkoLab https://t.co/vWZP1IcW19

2022-11-16 16:37:07 Humidity (indoor, relative) is associated with outcomes of Covid infections, a population-based study in 121 countries https://t.co/dWMmyMfBSL https://t.co/hW7Jq1mhdo

2022-11-16 01:17:21 RT @PeterHotez: Important and well-conducted study by @EricTopol My take: even though rebound is real and significant, in my conversation…

2022-11-15 23:33:25 For the people pointing out that @POTUS, @CDCDirector and Tony Fauci all had Paxlovid rebound, that's why you do prospective, systematic studies. We've learned that "rebound" also occurs without Paxlovid and that anecdotes/twitter are not representative of the real world

2022-11-15 20:14:34 Each participant did rapid antigen testing every other day through day 15, symptom surveys through day 17, and are being followed for 6 months https://t.co/8bDtswdytR

2022-11-15 20:00:32 The event curves for Paxlovid treated compared with controls https://t.co/2ykeOuBUAX

2022-11-15 19:56:25 Our prospective Paxlovid rebound study with controls preprint is posted By symptoms: ~12% rebound (19% Pax vs 7% controls) By positive testing: ~5% rebound (14% Pax vs 9% controls) Much lower than many estimates https://t.co/czeGEYIJvA by @JayPandit @michaelmina_lab @ScrippsRTI

2022-11-15 19:45:43 Foundation #AI models come to science https://t.co/G7Xx31w1Of https://t.co/HNjVOs3J4I

2022-11-15 19:23:17 @Jdrodric12 that's right!

2022-11-15 18:47:56 @SarahWLaurence @ScrippsRTI Thank you!

2022-11-15 18:31:49 On a day when the world has reached about ~8 billion people, it's notable there have been >

2022-11-15 17:10:19 @surrogateexpare @Medscape Included here https://t.co/bugfFk44sh@Medscape Please fix the links

2022-11-15 17:09:38 This post has all the relevant links and review the recent its for protection vs #LongCovid https://t.co/bugfFk44sh

2022-11-15 16:30:20 Paxlovid interactionsA new report claims 14.6% of patients had contraindications to treatment. But most of these meds could have been safely stopped for 5 dayshttps://t.co/FP3o0J0eBzMore on this herehttps://t.co/i3pUyAJlAs @Medscape https://t.co/0tsAf3xUqu

2022-11-15 16:11:35 Start of new waves in South Korea and Japan, having sustained recent BA.5 waves and this variant still accounts for most new casesThe pandemic isn't over https://t.co/DhwWhZ4CJi

2022-11-15 16:01:28 Here's the article. A potential path to preventing brain tissue from dying https://t.co/ODGuD8X8iy

2022-11-15 00:48:03 Today's pandemic briefing on new booster data and the thick soup of new variantshttps://t.co/LA3nl6FxSx

2022-11-14 17:22:13 RT @danrdanny: Excited to see our work on 3-hour genome sequencing highlighted here! If you think this is interesting we have a bench scien…

2022-11-14 17:04:44 The potential for detecting heart dysfunction (ejection fraction <

2022-11-14 14:37:14 RT @EricTopol: Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so m…

2022-11-14 14:28:16 In aggregate, solid evidence that the bivalent booster elicits a strong and broadened neutralizing antibody immune response. Yet, less than 27% of Americans 65+, the have had it and poor uptake across all age groupshttps://t.co/V5Xlj3cKln

2022-11-14 14:28:15 https://t.co/fJbLUdcYJdCoverage @statnews by @matthewherper w/ @SutharLab, whose results were replicated by the new data (Table)

2022-11-14 12:00:01 Moderna BA.5 bivalent booster results announced (via @moderna_tx press release)—largest study to date of >

2022-11-22 23:11:25 In synch with the hopeful tone https://t.co/uliFt9RZTS https://t.co/tHHLSvHdfg

2022-11-22 20:53:31 Vaccine effectiveness vs reinfection, a Denmark nationwide study The reduction of reinfection after primary vaccination was significant for the Alpha, Delta, and Omicron variant periods, ranging from 60-94%, lasting up to 9 months https://t.co/C9gWMfC1Tc @PLOSMedicine https://t.co/5VZq1Hgwk2

2022-11-22 20:46:42 Illuminating new @CDCMMWR repot for real world Paxlovid reduction of hospitalization by ~50% across all subgroups by age, vaccinated status, prior infection, month of infection (proxy for variant) https://t.co/LoMLSPepmd https://t.co/oLNscrf5M4

2022-11-22 20:05:09 New @CDCgov data for reduction of deaths by vaccination/boosters for age 12+ through September 2022 https://t.co/HGyjNwCm0v https://t.co/zo345UNZgb

2022-11-22 16:19:46 “Americans have been trained for 100 years to think that the hospital is the best place to be, the safest place. But we have strong evidence that the outcomes are actually better at home.” The hospital-at-home movement is just getting started https://t.co/TnfDzSCeoK @paula_span https://t.co/tvxqFMqwE5

2022-11-22 16:07:48 Our digital times :-) by @speedbumpcomic https://t.co/owtpzW5NqN

2022-11-21 16:14:51 As of 10 November 2022, it is estimated that 94% of Americans have had Covid at least once, much of those infections in the past year. Ranking of states w/ most vulnerability d/t lack of vaccines/ boosters https://t.co/W5zzyrD0vN @HarvardChanSPH https://t.co/FlY9MqC3Jq

2022-11-21 14:55:09 Unlike the prior 2 holiday seasons in the US, a major surge is unlikely, which is not in keeping with new, dominant variants with marked immune evasion. https://t.co/DqMJ7LAALu However, waning of immunity, poor uptake of boosters, and lack of mitigation sets up vulnerability https://t.co/rEQSBzeewg

2022-11-21 14:38:35 Encouraging new data for @Novavax boosters (1st and 2nd) for inducing neutralizing antibody response vs BA.5 https://t.co/CmpPueCwuG https://t.co/sbeWpljL7e

2022-11-21 14:28:55 Myocarditis after mRNA Covid vaccines: results from over 10 million doses in British Columbia https://t.co/CrnzxyPSDX @CMAJ https://t.co/y4rcdcJS67

2022-11-21 03:25:03 @kjhyuijhybh Yes I did that https://t.co/mJyBxYKymV

2022-11-21 03:24:06 @fstults2 https://t.co/mJyBxZ1BoV works

2022-11-21 01:21:26 Tumors also can have fungi within them which can, like (and interact with) bacteria, have functional impact on cancer and its therapy https://t.co/KDWV9XjQzW @CellCellPress https://t.co/72eyqbrMq0

2022-11-21 00:03:11 @steveagee Approved in China, India, Iran Big clinical trial in Mexico A company (Ocugen) has licensed the Bharat Biotech (India, IP from @WUSTL) for the United States but there’s no regulatory guidance by @US_FDA yet for Covid nasal vaccines

2022-11-20 23:46:08 RT @EricTopol: My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SAR…

2022-11-20 23:14:08 @kellyclose Both, Kelly. T1D mostly in young, predominantly T2D overall

2022-11-20 22:12:36 Great to see a big win for @UVA @UVAMensHoops

2022-11-20 19:10:31 https://t.co/N60zU6pExk

2022-11-20 19:10:30 Bacteria within tumors are capable of suppressing the immune response and promoting cancer spread https://t.co/g0WfQOd6lA @nature elegant work by @BullmanLab and @CJohnstonLab1 using spatial genomics https://t.co/K1sAMmpvhS https://t.co/C62S0nwLFR

2022-11-20 18:55:24 The consistent increased risk of diabetes after Covid across all age groups, highest in the first 3 months after infection, from a systematic review of 9 studies, ~40 million people https://t.co/uJ5T3ENGrj https://t.co/GZzZmhDrfH

2022-11-20 18:41:40 No need to dream anymore. This can be done. But it takes will, priority and funding And debunking the delusion that we're done with #SARSCoV2 https://t.co/TrR777xZTI https://t.co/eKHGg7EPtM https://t.co/1ijx5gN79W

2022-11-20 17:54:58 Months ago @VirusesImmunity and I laid out the strong case for nasal vaccines to achieve containment of the virus, breaking the chain of transmission at the individual and population level https://t.co/OujfFxMgU6 @SciImmunology https://t.co/lPGQTC2T1i

2022-11-20 16:23:27 I'm outraged by this pathetic and inexcusable inability for this country to go after nasal and better, durable, variant-proof vaccines https://t.co/u2AErUyYpN https://t.co/CuRQ51q8pi

2022-11-20 16:10:23 The variants accounting for new cases in Japan as of 11 November https://t.co/Tkkh0fwsf9 https://t.co/2JPHxUOxG1

2022-11-20 15:58:24 There's a 2nd BA.5 wave happening in Japan, the country that has best managed the pandemic https://t.co/z68bDAyl3a https://t.co/FTGx5BB1qt

2022-11-20 15:45:21 Why is the outlook favorable when new variants with marked immune evasion and growth advantage have become dominant? https://t.co/DqMJ7LSJZC

2022-11-19 20:21:41 A new and useful perspective on this report @NatRevNeurol https://t.co/wZ9kvh567Q by @alessandro5161 and @andreapilotto https://t.co/cjturtGVq2

2022-11-19 20:00:42 @TheLarvinMewis Thank you!

2022-11-19 19:46:26 My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SARSCoV2 variant with a marked increase in immune evasion not to have induced a wave. https://t.co/DqMJ7LAALu

2022-11-19 15:35:10 Correcting my typo: it's ronna, not rona More on this here @nature by @LizzieGibney https://t.co/Erb4zTYWCl https://t.co/zMGRoGHeTk

2022-11-19 15:20:02 I thought that many bytes should be named helluva but the new name is quetta https://t.co/d77lA6LTc2

2022-11-19 00:57:34 This poses a major concern for immunocompromised who have benefited from Evusheld (preventive) &

2022-11-19 00:57:33 The BQ.1.1 variant, as compared with many of the other new variants, is resistant to all clinically used monoclonal antibodies. BQ.1/BQ.1.1 are now the dominant variants in the United States https://t.co/PCFPSGF2uy @TheLancetInfDis https://t.co/dHucxoGokC

2022-11-18 21:17:45 Good news: 1st drug to alter the course of Type 1 diabetes in 100 years approved by @US_FDA Bad news: it costs ~$200,000/14-day treatment

2022-11-18 20:40:04 @legalnomads BA.1 bivalent induces about half as much neutralizing antibodies vs BA.5 as the BA.5 bivalent (live virus assays), both better than original booster. Whether that translates to any difference clinically is unclear.

2022-11-18 20:12:01 The bivalent BA.1 booster is being use in many countries around the world, but data are limited compared with the original (WT) booster against BA.5. New today: doubling of neutralizing antibodies https://t.co/M2YUB5wpH4 (BA.5 bivalent was ~3-5X WT in several recent studies) https://t.co/xYwnfcXkm6

2022-11-18 18:44:04 How to improve science discovery and productivity? Not just about money (see graph below): funding fast, bets on talent/people, take risk, think big https://t.co/HEAXu2L87H by @greg_ip w/ @patrickc @tylercowen @pdhsu https://t.co/7O6qplOf9C

2022-11-18 18:01:46 @KMunoz46 Correct. That's why there's no good explanation

2022-11-18 17:44:15 RT @ElinSilveous: “Foreign rivals have raced ahead in approving long-awaited nasal-spray vaccines, including one invented in St. Louis, cre…

2022-11-18 17:27:39 Does going to @NFL games increase risk of Covid? https://t.co/UzghLiDCgT Interesting findings of an association in the 14-21 day postgame period when >

2022-11-18 16:57:29 If you'd like to boost your protection vs BQ.1.1, 2 new studies that back up the bivalent as the way to get that done https://t.co/wAoTyur6be https://t.co/fDF4KEyJAL https://t.co/FiBnQRxlMG

2022-11-18 16:52:03 US Covid genomics

2022-11-18 15:54:32 A systematic review of Covid vaccines for kids age 5 to 11 (30 studies) Effectiveness 75% vs hospitalization

2022-11-18 15:45:27 @TopherSpiro46 @AshishKJha46 I know, Topher. Absolutely no reason for refusal of Congress and failure to fund. Appreciate @ashishkjha's strong advocacy

2022-11-18 14:58:07 An explainer for why the US is not pursuing nasal vaccines. TLDR: there is no good explanation https://t.co/Ih6ypzOva7 by @benjmueller w/ @VirusesImmunity @florian_krammer

2022-11-18 05:38:35 @hola_jonathan Many thanks!

2022-11-18 05:37:46 @amuendelheim Thanks!

2022-11-18 05:10:48 I'll be here until the lights go out........ You can also find me @erictopol@mstdn.social and https://t.co/YllXWa0b4k https://t.co/5rfMlDkCdM

2022-11-18 03:51:13 @lainemartin1 Very appreciative of your note!

2022-11-18 03:33:22 Refers to BQ.1.1 (see blue arrow)

2022-11-18 03:32:12 New data for why a bivalent booster will help: "These data suggest the bivalent BA.4/5 vaccine is more immunogenic than the original ...vaccine against circulating Omicron sublineages, including BQ.1.1 that is becoming prevalent globally." https://t.co/wAoTyur6be Get boosted! https://t.co/j21g0bELIp

2022-11-18 00:42:08 By current variant growth advantage patterns, the next couple of months in the US will be BQ.1.x dominated. Bivalent boosters will help protect

2022-11-18 00:20:49 @WHCOS Nicely put, Ron. Thanks!

2022-11-18 00:20:19 RT @WHCOS: In simpler terms: Go get your new COVID vaccination now.

2022-11-18 00:06:48 What science forgot during the pandemic https://t.co/12ffbs3ZOF by @richardhorton1 @TheLancet https://t.co/aoJSA3dEco

2022-11-17 23:56:45 A new report confirms the immune escape of the BQ.1.1 variant, along with BA.4.6 &

2022-11-17 23:26:54 We still don't have a way to diagnosis chronic traumatic encephalopathy (CTE) in people who are alive, but may be getting closer https://t.co/SftRQR7TWD by @el_belson @NYTSports https://t.co/BTh6oXUxRg

2022-11-17 21:47:06 RT @rowlsmanthorpe: Long covid has wrecked my life It’s bad, very bad. But you knew that already I want to tell you a hopeful story. A st…

2022-11-17 19:37:27 @PraliNoisette I don't see any sign of that https://t.co/e7u7aZCfBZ

2022-11-17 19:12:51 To note https://t.co/y2qdjFrvDR

2022-11-17 19:11:30 75 years later we have chips with >

2022-11-17 18:08:47 BA.5, déjà vu https://t.co/eILO8PxIkY

2022-11-17 17:33:41 RT @linseymarr: You get a 2-for-1 with filtration. It removes virus from the air and PM2.5 that is associated with an increased risk of inf…

2022-11-17 17:28:45 RT @Aiims1742: Important #OpenAccess paper in @Cancer_Cell from @CharlesSwanton &

2022-11-17 17:09:54 Strong evidence that particulate matter air pollution (ambient PM2.5) increases the risk of Covid infection, a systematic analysis https://t.co/RueG44Hk2m @MonashUni https://t.co/kpREoqJVPi

2022-11-17 15:46:50 About 1 in 5 of us have an APOE4 gene variant, the #1 genetic risk factor for Alzheimer's disease. But the mechanism for brain injury was a mystery, now getting unraveled (cholesterol processing by oligodendrocytes) https://t.co/gIpGt0CA28 @nature https://t.co/hbmdpO6R3t https://t.co/4zFZIhUTCI

2022-11-17 01:27:50 @amitsurg Because they do. That's mostly related to the excess of rebound after Paxlovid

2022-11-17 00:58:05 We've (re-)learned a few important lessons from the Paxlovid rebound experience about randomized trials and real world evidence Reviewed here https://t.co/jmT9vIipg9

2022-11-16 19:46:41 The Paxlovid rebound story New data reviewed in the 16 November daily briefing of Ground Truths https://t.co/jmT9vIipg9

2022-11-16 17:48:15 The US Covid death rate (7-day average) drops below 300 for the first time since June 2022. Lowest since pandemic began was 222 in July 2021. https://t.co/Cze8bZgtVr https://t.co/uxGosRY1KO

2022-11-16 17:14:12 Immunotherapy can induce myocarditis but the mechanism has been poorly understood. A new report @nature today supports the culprit auto-antigen role of α-myosin and cytotoxic T-cells directed to it https://t.co/uPRUQBbkVh by @MargaretAxelrod @BalkoLab https://t.co/vWZP1IcW19

2022-11-16 16:37:07 Humidity (indoor, relative) is associated with outcomes of Covid infections, a population-based study in 121 countries https://t.co/dWMmyMfBSL https://t.co/hW7Jq1mhdo

2022-11-16 01:17:21 RT @PeterHotez: Important and well-conducted study by @EricTopol My take: even though rebound is real and significant, in my conversation…

2022-11-15 23:33:25 For the people pointing out that @POTUS, @CDCDirector and Tony Fauci all had Paxlovid rebound, that's why you do prospective, systematic studies. We've learned that "rebound" also occurs without Paxlovid and that anecdotes/twitter are not representative of the real world

2022-11-15 20:14:34 Each participant did rapid antigen testing every other day through day 15, symptom surveys through day 17, and are being followed for 6 months https://t.co/8bDtswdytR

2022-11-15 20:00:32 The event curves for Paxlovid treated compared with controls https://t.co/2ykeOuBUAX

2022-11-15 19:56:25 Our prospective Paxlovid rebound study with controls preprint is posted By symptoms: ~12% rebound (19% Pax vs 7% controls) By positive testing: ~5% rebound (14% Pax vs 9% controls) Much lower than many estimates https://t.co/czeGEYIJvA by @JayPandit @michaelmina_lab @ScrippsRTI

2022-11-15 19:45:43 Foundation #AI models come to science https://t.co/G7Xx31w1Of https://t.co/HNjVOs3J4I

2022-11-15 19:23:17 @Jdrodric12 that's right!

2022-11-15 18:47:56 @SarahWLaurence @ScrippsRTI Thank you!

2022-11-15 18:31:49 On a day when the world has reached about ~8 billion people, it's notable there have been >

2022-11-15 17:10:19 @surrogateexpare @Medscape Included here https://t.co/bugfFk44sh@Medscape Please fix the links

2022-11-15 17:09:38 This post has all the relevant links and review the recent its for protection vs #LongCovid https://t.co/bugfFk44sh

2022-11-15 16:30:20 Paxlovid interactionsA new report claims 14.6% of patients had contraindications to treatment. But most of these meds could have been safely stopped for 5 dayshttps://t.co/FP3o0J0eBzMore on this herehttps://t.co/i3pUyAJlAs @Medscape https://t.co/0tsAf3xUqu

2022-11-15 16:11:35 Start of new waves in South Korea and Japan, having sustained recent BA.5 waves and this variant still accounts for most new casesThe pandemic isn't over https://t.co/DhwWhZ4CJi

2022-11-15 16:01:28 Here's the article. A potential path to preventing brain tissue from dying https://t.co/ODGuD8X8iy

2022-11-15 00:48:03 Today's pandemic briefing on new booster data and the thick soup of new variantshttps://t.co/LA3nl6FxSx

2022-11-14 17:22:13 RT @danrdanny: Excited to see our work on 3-hour genome sequencing highlighted here! If you think this is interesting we have a bench scien…

2022-11-14 17:04:44 The potential for detecting heart dysfunction (ejection fraction <

2022-11-14 14:37:14 RT @EricTopol: Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so m…

2022-11-14 14:28:16 In aggregate, solid evidence that the bivalent booster elicits a strong and broadened neutralizing antibody immune response. Yet, less than 27% of Americans 65+, the have had it and poor uptake across all age groupshttps://t.co/V5Xlj3cKln

2022-11-14 14:28:15 https://t.co/fJbLUdcYJdCoverage @statnews by @matthewherper w/ @SutharLab, whose results were replicated by the new data (Table)

2022-11-14 12:00:01 Moderna BA.5 bivalent booster results announced (via @moderna_tx press release)—largest study to date of >

2022-11-24 19:58:48 The growing body of evidence that the 3 respiratory viruses (Covid, flu, RSV) interfere with each other’s spread, limiting a tripledemic's threat https://t.co/auPadYfbsa @ScienceMagazine by @sciencecohen https://t.co/yUKqrZyNUW

2022-11-24 19:25:13 We're heading to a universal toolkit to engineer cells for diverse applications: cancer, autoimmune conditions, neurodegenerative diseases, repair of injured tissue and organs https://t.co/a1h3N2QCQY This week's @ScienceMagazine special section https://t.co/lPuSGVmA5F

2022-11-24 19:04:59 Just published @ScienceMagazine A universal influenza mRNA vaccine effective against all 20 lineages of influenza A and B, effective in experimental models https://t.co/CfABwuE2O0 https://t.co/hyA6lktAgX https://t.co/eyteciqmY2

2022-11-24 02:17:36 There is an impersonator of me, a fake account @EricTopol5, that has been reported @twitter @TwitterSupport

2022-11-24 00:21:29 The stigma and discrimination faced by most people with #LongCovid https://t.co/s4EYkgCv10 @PLOSONE by @PantelichMarija @Dr2NisreenAlwan and colleagues https://t.co/F8MdNUYAGd

2022-11-24 00:11:41 "Our results suggest that the development of a mucosal booster vaccine dose should be further exploited to induce a stronger sIgA response." @NEJM https://t.co/OPEaVtZmQT More rationale a nasal vaccine booster and benefit of mucosal immunity to augment salivary IgA https://t.co/JTX8sDrLyV

2022-11-23 23:35:06 This is about the short term outlook only, as I reviewed here https://t.co/DqMJ7LAALu still needed

2022-11-23 22:43:13 A very informative, fun and engaging conversation with @trishgreenhalgh about what constitutes evidence in medicine and the pandemic https://t.co/IaVXavjlC7 W/ @cuttingforstone @Medscape

2022-11-23 17:53:31 On the 1-year anniversary of Omicron’s detection, things are looking up. Worse variants countered by tens of millions of infections, vaccines, and boosters make a difference https://t.co/AsFyGcpFK9

2022-11-23 16:33:10 Japan's 2nd BA.5 wave reaches case peak level of Omicron BA.1 (>

2022-11-23 16:02:02 Good Intro editing :-) by @stephanpastis https://t.co/do6Lg8W93j

2022-11-22 23:11:25 In synch with the hopeful tone https://t.co/uliFt9RZTS https://t.co/tHHLSvHdfg

2022-11-22 20:53:31 Vaccine effectiveness vs reinfection, a Denmark nationwide study The reduction of reinfection after primary vaccination was significant for the Alpha, Delta, and Omicron variant periods, ranging from 60-94%, lasting up to 9 months https://t.co/C9gWMfC1Tc @PLOSMedicine https://t.co/5VZq1Hgwk2

2022-11-22 20:46:42 Illuminating new @CDCMMWR repot for real world Paxlovid reduction of hospitalization by ~50% across all subgroups by age, vaccinated status, prior infection, month of infection (proxy for variant) https://t.co/LoMLSPepmd https://t.co/oLNscrf5M4

2022-11-22 20:05:09 New @CDCgov data for reduction of deaths by vaccination/boosters for age 12+ through September 2022 https://t.co/HGyjNwCm0v https://t.co/zo345UNZgb

2022-11-22 16:19:46 “Americans have been trained for 100 years to think that the hospital is the best place to be, the safest place. But we have strong evidence that the outcomes are actually better at home.” The hospital-at-home movement is just getting started https://t.co/TnfDzSCeoK @paula_span https://t.co/tvxqFMqwE5

2022-11-22 16:07:48 Our digital times :-) by @speedbumpcomic https://t.co/owtpzW5NqN

2022-11-21 16:14:51 As of 10 November 2022, it is estimated that 94% of Americans have had Covid at least once, much of those infections in the past year. Ranking of states w/ most vulnerability d/t lack of vaccines/ boosters https://t.co/W5zzyrD0vN @HarvardChanSPH https://t.co/FlY9MqC3Jq

2022-11-21 14:55:09 Unlike the prior 2 holiday seasons in the US, a major surge is unlikely, which is not in keeping with new, dominant variants with marked immune evasion. https://t.co/DqMJ7LAALu However, waning of immunity, poor uptake of boosters, and lack of mitigation sets up vulnerability https://t.co/rEQSBzeewg

2022-11-21 14:38:35 Encouraging new data for @Novavax boosters (1st and 2nd) for inducing neutralizing antibody response vs BA.5 https://t.co/CmpPueCwuG https://t.co/sbeWpljL7e

2022-11-21 14:28:55 Myocarditis after mRNA Covid vaccines: results from over 10 million doses in British Columbia https://t.co/CrnzxyPSDX @CMAJ https://t.co/y4rcdcJS67

2022-11-21 03:25:03 @kjhyuijhybh Yes I did that https://t.co/mJyBxYKymV

2022-11-21 03:24:06 @fstults2 https://t.co/mJyBxZ1BoV works

2022-11-21 01:21:26 Tumors also can have fungi within them which can, like (and interact with) bacteria, have functional impact on cancer and its therapy https://t.co/KDWV9XjQzW @CellCellPress https://t.co/72eyqbrMq0

2022-11-21 00:03:11 @steveagee Approved in China, India, Iran Big clinical trial in Mexico A company (Ocugen) has licensed the Bharat Biotech (India, IP from @WUSTL) for the United States but there’s no regulatory guidance by @US_FDA yet for Covid nasal vaccines

2022-11-20 23:46:08 RT @EricTopol: My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SAR…

2022-11-20 23:14:08 @kellyclose Both, Kelly. T1D mostly in young, predominantly T2D overall

2022-11-20 22:12:36 Great to see a big win for @UVA @UVAMensHoops

2022-11-20 19:10:31 https://t.co/N60zU6pExk

2022-11-20 19:10:30 Bacteria within tumors are capable of suppressing the immune response and promoting cancer spread https://t.co/g0WfQOd6lA @nature elegant work by @BullmanLab and @CJohnstonLab1 using spatial genomics https://t.co/K1sAMmpvhS https://t.co/C62S0nwLFR

2022-11-20 18:55:24 The consistent increased risk of diabetes after Covid across all age groups, highest in the first 3 months after infection, from a systematic review of 9 studies, ~40 million people https://t.co/uJ5T3ENGrj https://t.co/GZzZmhDrfH

2022-11-20 18:41:40 No need to dream anymore. This can be done. But it takes will, priority and funding And debunking the delusion that we're done with #SARSCoV2 https://t.co/TrR777xZTI https://t.co/eKHGg7EPtM https://t.co/1ijx5gN79W

2022-11-20 17:54:58 Months ago @VirusesImmunity and I laid out the strong case for nasal vaccines to achieve containment of the virus, breaking the chain of transmission at the individual and population level https://t.co/OujfFxMgU6 @SciImmunology https://t.co/lPGQTC2T1i

2022-11-20 16:23:27 I'm outraged by this pathetic and inexcusable inability for this country to go after nasal and better, durable, variant-proof vaccines https://t.co/u2AErUyYpN https://t.co/CuRQ51q8pi

2022-11-20 16:10:23 The variants accounting for new cases in Japan as of 11 November https://t.co/Tkkh0fwsf9 https://t.co/2JPHxUOxG1

2022-11-20 15:58:24 There's a 2nd BA.5 wave happening in Japan, the country that has best managed the pandemic https://t.co/z68bDAyl3a https://t.co/FTGx5BB1qt

2022-11-20 15:45:21 Why is the outlook favorable when new variants with marked immune evasion and growth advantage have become dominant? https://t.co/DqMJ7LSJZC

2022-11-19 20:21:41 A new and useful perspective on this report @NatRevNeurol https://t.co/wZ9kvh567Q by @alessandro5161 and @andreapilotto https://t.co/cjturtGVq2

2022-11-19 20:00:42 @TheLarvinMewis Thank you!

2022-11-19 19:46:26 My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SARSCoV2 variant with a marked increase in immune evasion not to have induced a wave. https://t.co/DqMJ7LAALu

2022-11-19 15:35:10 Correcting my typo: it's ronna, not rona More on this here @nature by @LizzieGibney https://t.co/Erb4zTYWCl https://t.co/zMGRoGHeTk

2022-11-19 15:20:02 I thought that many bytes should be named helluva but the new name is quetta https://t.co/d77lA6LTc2

2022-11-19 00:57:34 This poses a major concern for immunocompromised who have benefited from Evusheld (preventive) &

2022-11-19 00:57:33 The BQ.1.1 variant, as compared with many of the other new variants, is resistant to all clinically used monoclonal antibodies. BQ.1/BQ.1.1 are now the dominant variants in the United States https://t.co/PCFPSGF2uy @TheLancetInfDis https://t.co/dHucxoGokC

2022-11-18 21:17:45 Good news: 1st drug to alter the course of Type 1 diabetes in 100 years approved by @US_FDA Bad news: it costs ~$200,000/14-day treatment

2022-11-18 20:40:04 @legalnomads BA.1 bivalent induces about half as much neutralizing antibodies vs BA.5 as the BA.5 bivalent (live virus assays), both better than original booster. Whether that translates to any difference clinically is unclear.

2022-11-18 20:12:01 The bivalent BA.1 booster is being use in many countries around the world, but data are limited compared with the original (WT) booster against BA.5. New today: doubling of neutralizing antibodies https://t.co/M2YUB5wpH4 (BA.5 bivalent was ~3-5X WT in several recent studies) https://t.co/xYwnfcXkm6

2022-11-18 18:44:04 How to improve science discovery and productivity? Not just about money (see graph below): funding fast, bets on talent/people, take risk, think big https://t.co/HEAXu2L87H by @greg_ip w/ @patrickc @tylercowen @pdhsu https://t.co/7O6qplOf9C

2022-11-18 18:01:46 @KMunoz46 Correct. That's why there's no good explanation

2022-11-18 17:44:15 RT @ElinSilveous: “Foreign rivals have raced ahead in approving long-awaited nasal-spray vaccines, including one invented in St. Louis, cre…

2022-11-18 17:27:39 Does going to @NFL games increase risk of Covid? https://t.co/UzghLiDCgT Interesting findings of an association in the 14-21 day postgame period when >

2022-11-18 16:57:29 If you'd like to boost your protection vs BQ.1.1, 2 new studies that back up the bivalent as the way to get that done https://t.co/wAoTyur6be https://t.co/fDF4KEyJAL https://t.co/FiBnQRxlMG

2022-11-18 16:52:03 US Covid genomics

2022-11-18 15:54:32 A systematic review of Covid vaccines for kids age 5 to 11 (30 studies) Effectiveness 75% vs hospitalization

2022-11-18 15:45:27 @TopherSpiro46 @AshishKJha46 I know, Topher. Absolutely no reason for refusal of Congress and failure to fund. Appreciate @ashishkjha's strong advocacy

2022-11-18 14:58:07 An explainer for why the US is not pursuing nasal vaccines. TLDR: there is no good explanation https://t.co/Ih6ypzOva7 by @benjmueller w/ @VirusesImmunity @florian_krammer

2022-11-18 05:38:35 @hola_jonathan Many thanks!

2022-11-18 05:37:46 @amuendelheim Thanks!

2022-11-18 05:10:48 I'll be here until the lights go out........ You can also find me @erictopol@mstdn.social and https://t.co/YllXWa0b4k https://t.co/5rfMlDkCdM

2022-11-18 03:51:13 @lainemartin1 Very appreciative of your note!

2022-11-18 03:33:22 Refers to BQ.1.1 (see blue arrow)

2022-11-18 03:32:12 New data for why a bivalent booster will help: "These data suggest the bivalent BA.4/5 vaccine is more immunogenic than the original ...vaccine against circulating Omicron sublineages, including BQ.1.1 that is becoming prevalent globally." https://t.co/wAoTyur6be Get boosted! https://t.co/j21g0bELIp

2022-11-18 00:42:08 By current variant growth advantage patterns, the next couple of months in the US will be BQ.1.x dominated. Bivalent boosters will help protect

2022-11-18 00:20:49 @WHCOS Nicely put, Ron. Thanks!

2022-11-18 00:20:19 RT @WHCOS: In simpler terms: Go get your new COVID vaccination now.

2022-11-18 00:06:48 What science forgot during the pandemic https://t.co/12ffbs3ZOF by @richardhorton1 @TheLancet https://t.co/aoJSA3dEco

2022-11-17 23:56:45 A new report confirms the immune escape of the BQ.1.1 variant, along with BA.4.6 &

2022-11-17 23:26:54 We still don't have a way to diagnosis chronic traumatic encephalopathy (CTE) in people who are alive, but may be getting closer https://t.co/SftRQR7TWD by @el_belson @NYTSports https://t.co/BTh6oXUxRg

2022-11-17 21:47:06 RT @rowlsmanthorpe: Long covid has wrecked my life It’s bad, very bad. But you knew that already I want to tell you a hopeful story. A st…

2022-11-17 19:37:27 @PraliNoisette I don't see any sign of that https://t.co/e7u7aZCfBZ

2022-11-17 19:12:51 To note https://t.co/y2qdjFrvDR

2022-11-17 19:11:30 75 years later we have chips with >

2022-11-17 18:08:47 BA.5, déjà vu https://t.co/eILO8PxIkY

2022-11-17 17:33:41 RT @linseymarr: You get a 2-for-1 with filtration. It removes virus from the air and PM2.5 that is associated with an increased risk of inf…

2022-11-17 17:28:45 RT @Aiims1742: Important #OpenAccess paper in @Cancer_Cell from @CharlesSwanton &

2022-11-17 17:09:54 Strong evidence that particulate matter air pollution (ambient PM2.5) increases the risk of Covid infection, a systematic analysis https://t.co/RueG44Hk2m @MonashUni https://t.co/kpREoqJVPi

2022-11-17 15:46:50 About 1 in 5 of us have an APOE4 gene variant, the #1 genetic risk factor for Alzheimer's disease. But the mechanism for brain injury was a mystery, now getting unraveled (cholesterol processing by oligodendrocytes) https://t.co/gIpGt0CA28 @nature https://t.co/hbmdpO6R3t https://t.co/4zFZIhUTCI

2022-11-17 01:27:50 @amitsurg Because they do. That's mostly related to the excess of rebound after Paxlovid

2022-11-17 00:58:05 We've (re-)learned a few important lessons from the Paxlovid rebound experience about randomized trials and real world evidence Reviewed here https://t.co/jmT9vIipg9

2022-11-16 19:46:41 The Paxlovid rebound story New data reviewed in the 16 November daily briefing of Ground Truths https://t.co/jmT9vIipg9

2022-11-16 17:48:15 The US Covid death rate (7-day average) drops below 300 for the first time since June 2022. Lowest since pandemic began was 222 in July 2021. https://t.co/Cze8bZgtVr https://t.co/uxGosRY1KO

2022-11-16 17:14:12 Immunotherapy can induce myocarditis but the mechanism has been poorly understood. A new report @nature today supports the culprit auto-antigen role of α-myosin and cytotoxic T-cells directed to it https://t.co/uPRUQBbkVh by @MargaretAxelrod @BalkoLab https://t.co/vWZP1IcW19

2022-11-16 16:37:07 Humidity (indoor, relative) is associated with outcomes of Covid infections, a population-based study in 121 countries https://t.co/dWMmyMfBSL https://t.co/hW7Jq1mhdo

2022-11-16 01:17:21 RT @PeterHotez: Important and well-conducted study by @EricTopol My take: even though rebound is real and significant, in my conversation…

2022-11-15 23:33:25 For the people pointing out that @POTUS, @CDCDirector and Tony Fauci all had Paxlovid rebound, that's why you do prospective, systematic studies. We've learned that "rebound" also occurs without Paxlovid and that anecdotes/twitter are not representative of the real world

2022-11-15 20:14:34 Each participant did rapid antigen testing every other day through day 15, symptom surveys through day 17, and are being followed for 6 months https://t.co/8bDtswdytR

2022-11-15 20:00:32 The event curves for Paxlovid treated compared with controls https://t.co/2ykeOuBUAX

2022-11-15 19:56:25 Our prospective Paxlovid rebound study with controls preprint is posted By symptoms: ~12% rebound (19% Pax vs 7% controls) By positive testing: ~5% rebound (14% Pax vs 9% controls) Much lower than many estimates https://t.co/czeGEYIJvA by @JayPandit @michaelmina_lab @ScrippsRTI

2022-11-15 19:45:43 Foundation #AI models come to science https://t.co/G7Xx31w1Of https://t.co/HNjVOs3J4I

2022-11-15 19:23:17 @Jdrodric12 that's right!

2022-11-15 18:47:56 @SarahWLaurence @ScrippsRTI Thank you!

2022-11-15 18:31:49 On a day when the world has reached about ~8 billion people, it's notable there have been >

2022-11-15 17:10:19 @surrogateexpare @Medscape Included here https://t.co/bugfFk44sh@Medscape Please fix the links

2022-11-15 17:09:38 This post has all the relevant links and review the recent its for protection vs #LongCovid https://t.co/bugfFk44sh

2022-11-15 16:30:20 Paxlovid interactionsA new report claims 14.6% of patients had contraindications to treatment. But most of these meds could have been safely stopped for 5 dayshttps://t.co/FP3o0J0eBzMore on this herehttps://t.co/i3pUyAJlAs @Medscape https://t.co/0tsAf3xUqu

2022-11-15 16:11:35 Start of new waves in South Korea and Japan, having sustained recent BA.5 waves and this variant still accounts for most new casesThe pandemic isn't over https://t.co/DhwWhZ4CJi

2022-11-15 16:01:28 Here's the article. A potential path to preventing brain tissue from dying https://t.co/ODGuD8X8iy

2022-11-15 00:48:03 Today's pandemic briefing on new booster data and the thick soup of new variantshttps://t.co/LA3nl6FxSx

2022-11-14 17:22:13 RT @danrdanny: Excited to see our work on 3-hour genome sequencing highlighted here! If you think this is interesting we have a bench scien…

2022-11-14 17:04:44 The potential for detecting heart dysfunction (ejection fraction <

2022-11-14 14:37:14 RT @EricTopol: Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so m…

2022-11-14 14:28:16 In aggregate, solid evidence that the bivalent booster elicits a strong and broadened neutralizing antibody immune response. Yet, less than 27% of Americans 65+, the have had it and poor uptake across all age groupshttps://t.co/V5Xlj3cKln

2022-11-14 14:28:15 https://t.co/fJbLUdcYJdCoverage @statnews by @matthewherper w/ @SutharLab, whose results were replicated by the new data (Table)

2022-11-14 12:00:01 Moderna BA.5 bivalent booster results announced (via @moderna_tx press release)—largest study to date of >

2022-11-29 01:23:20 RT @CorneliusRoemer: I'm seeing quite a bit of discussion about the potential impact of a big wave in mainland China on variant evolution.…

2022-11-29 00:43:08 Good thing it's so simple to predict optimal vaccine response

2022-11-28 22:36:33 In the 2nd year of the US pandemic "the shift in COVID-19 mortality to relatively younger people.. .contributed to markedly elevated years of life lost (YLL) from this increasingly preventable cause of death" https://t.co/Vj0DleONDZ @AnnalsofIM @MarkCzeisler https://t.co/nX7ZrnF9tG

2022-11-28 22:12:32 A randomized trial of medical masks vs N95s in health care workers to prevent Covid https://t.co/CSJkFLE15z —It's woefully underpowered but ruled out a doubling of hazard for use of medical masks —In 3 of the 4 countries there was less risk with N95s (p=NS) https://t.co/B7iBvT1J9B

2022-11-28 21:20:35 Despite David Ho and colleagues new preprint, I wrote that the concerns over these variants have yet to be clinically manifest. It's the 1st time in the pandemic that lab assays of marked increases in immune evasion have not played out w/ new major surges https://t.co/DqMJ7LSJZC

2022-11-28 20:51:49 "The extent of the antigenic drift or shift measured herein is comparable to the antigenic leap made by the initial Omicron variant from its predecessors one year ago." https://t.co/2wDWjZkTr7

2022-11-28 20:51:47 Nonetheless "Our findings indicate that BQ &

2022-11-28 20:42:33 A note of alarm from Ho lab about the immune escape features of XBB &

2022-11-28 19:52:20 Disruption of the gut microbiome by Covid infections https://t.co/eZO3FBW5xS by Martin Blaser and colleagues @RutgersCABM https://t.co/bFUwDEjFFJ

2022-11-28 19:25:44 Very concerning about the new drug w/modest effects for Alzheimer's disease (AD) "If the patient hadn’t been on lecanemab she would be alive today.” Underlying cerebral amyloid angiopathy is present in nearly half of AD patients https://t.co/UNRoKcICNw @cpiller @ScienceMagazine

2022-11-28 16:51:27 The pandemic isn't over. Besides the major trouble that is brewing in China, it's notable that Japan's new wave has exceeded its Omicron BA.1 surge, averaging over 100,000 cases/day, and still is on steep ascent @OurWorldInData https://t.co/XnNveiLs33

2022-11-28 16:43:14 It doesn't help that the @CDCgov still defines "fully vaccinated" as 2 shots, when it would now have taken 5 shots to counter the waning immunity/protect vs severe Covid for people age 50+

2022-11-28 15:34:09 Mask psychology by @lianafinck @NewYorker https://t.co/2uGXaeJhFe

2022-11-28 15:00:27 In the last month, nearly 90% of the deaths from Covid were in people age 65+ (16% of the US population). Their bivalent booster rate is less than 25%. Paxlovid use is low in seniors. A high % of these deaths are preventable. https://t.co/X3DTJcrU4F @arianaeunjung @dtkeating https://t.co/PBWUvsn3W4

2022-11-28 14:49:23 Help Elon :-) by @stephanpastis https://t.co/UMFrafyakl

2022-11-27 22:12:09 These projections for China were based on modeling. But with the low rate of seniors with booster shots, lower efficacy of their vaccines vs Omicron subvariants, and now inability to contain the virus, major trouble lies ahead https://t.co/2Ddz6coeNU

2022-11-27 03:40:59 If we can do a universal influenza vaccine, a pan-β-coronavirus (variant-proof) virus is well within reach!

2022-11-26 19:35:11 Not a good look for Covid in Arizona —Most increase in US hospitalizations in the past 2 weeks, notable in age 70+ —Hard to attribute to BQ.1.1 or other new variants https://t.co/Cze8bZxwXr https://t.co/xGxvgnpKiM

2022-11-26 17:01:55 The BQ.1.1 variant is resistant to all available monoclonal antibodies, including Evusheld and Bebtelovimab, leaving immunocompromised individuals particularly vulnerable. There are a few new antibodies currently being tested, with some promise https://t.co/Atfwxm2hjV @majohnso https://t.co/sjthau0XGT

2022-11-26 02:42:30 RT @DrTomasAragon: Here is are two papers from @trishgreenhalgh that complements this great podcast with @EricTopol - https://t.co/q9bk5jV…

2022-11-26 02:41:55 @dokhollidays Thank you!

2022-11-26 01:44:24 Evolution of the Omicron family of variants https://t.co/UnFls9aXeq by @CorneliusRoemer @LongDesertTrain @PeacockFlu and colleagues "It is entirely possible all the lineages described here would be outcompeted in the event of a second ‘Omicron-like event’" https://t.co/W0C7lTKx40

2022-11-25 21:18:05 RT @DrSethPT: “Whilst RCTs are a fantastic idea for testing drugs, they are a catastrophically bad idea for testing loads of other things.”…

2022-11-25 20:54:07 Genome editing to restore heart function of dilated cardiomyopathy in experimental model https://t.co/QsU87cYuAu @ScienceTM https://t.co/0msjDZmn1I

2022-11-25 17:29:51 Hope for avoiding a holiday Covid surge https://t.co/GpMStLVkrt by @jon_kamp In depth: https://t.co/DqMJ7LAALu https://t.co/gNqutFc8wm

2022-11-25 17:22:37 Common threads between #SARSCoV2 brain involvement and Alzheimer's disease at post-mortem: pattern of neuroinflammation and gene expression, microglia nodule formation, pathway activation, and vascular injury https://t.co/ln41iwTlvG @Pasing01 @IcahnMountSinai @IcahnCMIN https://t.co/UeUh2dOuRV

2022-11-25 16:51:06 Growth curves of BQ.1.1 and XBB in Region 2 (includes New York). The BQ.1s are >

2022-11-25 16:24:49 This week's CDC genomic update shows that 57% of new cases are due to BQ.1/BQ.1.1 variants as BA.5 fades and small increases in a few other variants (XBB, BN.1, BA.2.75) https://t.co/jjl2AnwOWX https://t.co/IWoEZFI5Rb

2022-11-25 15:57:51 Our digital times :-) @speedbumpcomic https://t.co/62Tuq2ozPl

2022-11-25 15:37:26 The molecular mechanism of #SARSCoV2 infection https://t.co/zxLN8q66Rf @ScienceMagazine highlighting the role of endosomes in a prize winning essay https://t.co/l3yukGRZ9B

2022-11-24 19:58:48 The growing body of evidence that the 3 respiratory viruses (Covid, flu, RSV) interfere with each other’s spread, limiting a tripledemic's threat https://t.co/auPadYfbsa @ScienceMagazine by @sciencecohen https://t.co/yUKqrZyNUW

2022-11-24 19:25:13 We're heading to a universal toolkit to engineer cells for diverse applications: cancer, autoimmune conditions, neurodegenerative diseases, repair of injured tissue and organs https://t.co/a1h3N2QCQY This week's @ScienceMagazine special section https://t.co/lPuSGVmA5F

2022-11-24 19:04:59 Just published @ScienceMagazine A universal influenza mRNA vaccine effective against all 20 lineages of influenza A and B, effective in experimental models https://t.co/CfABwuE2O0 https://t.co/hyA6lktAgX https://t.co/eyteciqmY2

2022-11-24 02:17:36 There is an impersonator of me, a fake account @EricTopol5, that has been reported @twitter @TwitterSupport

2022-11-24 00:21:29 The stigma and discrimination faced by most people with #LongCovid https://t.co/s4EYkgCv10 @PLOSONE by @PantelichMarija @Dr2NisreenAlwan and colleagues https://t.co/F8MdNUYAGd

2022-11-24 00:11:41 "Our results suggest that the development of a mucosal booster vaccine dose should be further exploited to induce a stronger sIgA response." @NEJM https://t.co/OPEaVtZmQT More rationale a nasal vaccine booster and benefit of mucosal immunity to augment salivary IgA https://t.co/JTX8sDrLyV

2022-11-23 23:35:06 This is about the short term outlook only, as I reviewed here https://t.co/DqMJ7LAALu still needed

2022-11-23 22:43:13 A very informative, fun and engaging conversation with @trishgreenhalgh about what constitutes evidence in medicine and the pandemic https://t.co/IaVXavjlC7 W/ @cuttingforstone @Medscape

2022-11-23 17:53:31 On the 1-year anniversary of Omicron’s detection, things are looking up. Worse variants countered by tens of millions of infections, vaccines, and boosters make a difference https://t.co/AsFyGcpFK9

2022-11-23 16:33:10 Japan's 2nd BA.5 wave reaches case peak level of Omicron BA.1 (>

2022-11-23 16:02:02 Good Intro editing :-) by @stephanpastis https://t.co/do6Lg8W93j

2022-11-22 23:11:25 In synch with the hopeful tone https://t.co/uliFt9RZTS https://t.co/tHHLSvHdfg

2022-11-22 20:53:31 Vaccine effectiveness vs reinfection, a Denmark nationwide study The reduction of reinfection after primary vaccination was significant for the Alpha, Delta, and Omicron variant periods, ranging from 60-94%, lasting up to 9 months https://t.co/C9gWMfC1Tc @PLOSMedicine https://t.co/5VZq1Hgwk2

2022-11-22 20:46:42 Illuminating new @CDCMMWR repot for real world Paxlovid reduction of hospitalization by ~50% across all subgroups by age, vaccinated status, prior infection, month of infection (proxy for variant) https://t.co/LoMLSPepmd https://t.co/oLNscrf5M4

2022-11-22 20:05:09 New @CDCgov data for reduction of deaths by vaccination/boosters for age 12+ through September 2022 https://t.co/HGyjNwCm0v https://t.co/zo345UNZgb

2022-11-22 16:19:46 “Americans have been trained for 100 years to think that the hospital is the best place to be, the safest place. But we have strong evidence that the outcomes are actually better at home.” The hospital-at-home movement is just getting started https://t.co/TnfDzSCeoK @paula_span https://t.co/tvxqFMqwE5

2022-11-22 16:07:48 Our digital times :-) by @speedbumpcomic https://t.co/owtpzW5NqN

2022-11-21 16:14:51 As of 10 November 2022, it is estimated that 94% of Americans have had Covid at least once, much of those infections in the past year. Ranking of states w/ most vulnerability d/t lack of vaccines/ boosters https://t.co/W5zzyrD0vN @HarvardChanSPH https://t.co/FlY9MqC3Jq

2022-11-21 14:55:09 Unlike the prior 2 holiday seasons in the US, a major surge is unlikely, which is not in keeping with new, dominant variants with marked immune evasion. https://t.co/DqMJ7LAALu However, waning of immunity, poor uptake of boosters, and lack of mitigation sets up vulnerability https://t.co/rEQSBzeewg

2022-11-21 14:38:35 Encouraging new data for @Novavax boosters (1st and 2nd) for inducing neutralizing antibody response vs BA.5 https://t.co/CmpPueCwuG https://t.co/sbeWpljL7e

2022-11-21 14:28:55 Myocarditis after mRNA Covid vaccines: results from over 10 million doses in British Columbia https://t.co/CrnzxyPSDX @CMAJ https://t.co/y4rcdcJS67

2022-11-21 03:25:03 @kjhyuijhybh Yes I did that https://t.co/mJyBxYKymV

2022-11-21 03:24:06 @fstults2 https://t.co/mJyBxZ1BoV works

2022-11-21 01:21:26 Tumors also can have fungi within them which can, like (and interact with) bacteria, have functional impact on cancer and its therapy https://t.co/KDWV9XjQzW @CellCellPress https://t.co/72eyqbrMq0

2022-11-21 00:03:11 @steveagee Approved in China, India, Iran Big clinical trial in Mexico A company (Ocugen) has licensed the Bharat Biotech (India, IP from @WUSTL) for the United States but there’s no regulatory guidance by @US_FDA yet for Covid nasal vaccines

2022-11-20 23:46:08 RT @EricTopol: My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SAR…

2022-11-20 23:14:08 @kellyclose Both, Kelly. T1D mostly in young, predominantly T2D overall

2022-11-20 22:12:36 Great to see a big win for @UVA @UVAMensHoops

2022-11-20 19:10:31 https://t.co/N60zU6pExk

2022-11-20 19:10:30 Bacteria within tumors are capable of suppressing the immune response and promoting cancer spread https://t.co/g0WfQOd6lA @nature elegant work by @BullmanLab and @CJohnstonLab1 using spatial genomics https://t.co/K1sAMmpvhS https://t.co/C62S0nwLFR

2022-11-20 18:55:24 The consistent increased risk of diabetes after Covid across all age groups, highest in the first 3 months after infection, from a systematic review of 9 studies, ~40 million people https://t.co/uJ5T3ENGrj https://t.co/GZzZmhDrfH

2022-11-20 18:41:40 No need to dream anymore. This can be done. But it takes will, priority and funding And debunking the delusion that we're done with #SARSCoV2 https://t.co/TrR777xZTI https://t.co/eKHGg7EPtM https://t.co/1ijx5gN79W

2022-11-20 17:54:58 Months ago @VirusesImmunity and I laid out the strong case for nasal vaccines to achieve containment of the virus, breaking the chain of transmission at the individual and population level https://t.co/OujfFxMgU6 @SciImmunology https://t.co/lPGQTC2T1i

2022-11-20 16:23:27 I'm outraged by this pathetic and inexcusable inability for this country to go after nasal and better, durable, variant-proof vaccines https://t.co/u2AErUyYpN https://t.co/CuRQ51q8pi

2022-11-20 16:10:23 The variants accounting for new cases in Japan as of 11 November https://t.co/Tkkh0fwsf9 https://t.co/2JPHxUOxG1

2022-11-20 15:58:24 There's a 2nd BA.5 wave happening in Japan, the country that has best managed the pandemic https://t.co/z68bDAyl3a https://t.co/FTGx5BB1qt

2022-11-20 15:45:21 Why is the outlook favorable when new variants with marked immune evasion and growth advantage have become dominant? https://t.co/DqMJ7LSJZC

2022-11-19 20:21:41 A new and useful perspective on this report @NatRevNeurol https://t.co/wZ9kvh567Q by @alessandro5161 and @andreapilotto https://t.co/cjturtGVq2

2022-11-19 20:00:42 @TheLarvinMewis Thank you!

2022-11-19 19:46:26 My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SARSCoV2 variant with a marked increase in immune evasion not to have induced a wave. https://t.co/DqMJ7LAALu

2022-11-19 15:35:10 Correcting my typo: it's ronna, not rona More on this here @nature by @LizzieGibney https://t.co/Erb4zTYWCl https://t.co/zMGRoGHeTk

2022-11-19 15:20:02 I thought that many bytes should be named helluva but the new name is quetta https://t.co/d77lA6LTc2

2022-11-19 00:57:34 This poses a major concern for immunocompromised who have benefited from Evusheld (preventive) &

2022-11-19 00:57:33 The BQ.1.1 variant, as compared with many of the other new variants, is resistant to all clinically used monoclonal antibodies. BQ.1/BQ.1.1 are now the dominant variants in the United States https://t.co/PCFPSGF2uy @TheLancetInfDis https://t.co/dHucxoGokC

2022-11-18 21:17:45 Good news: 1st drug to alter the course of Type 1 diabetes in 100 years approved by @US_FDA Bad news: it costs ~$200,000/14-day treatment

2022-11-18 20:40:04 @legalnomads BA.1 bivalent induces about half as much neutralizing antibodies vs BA.5 as the BA.5 bivalent (live virus assays), both better than original booster. Whether that translates to any difference clinically is unclear.

2022-11-18 20:12:01 The bivalent BA.1 booster is being use in many countries around the world, but data are limited compared with the original (WT) booster against BA.5. New today: doubling of neutralizing antibodies https://t.co/M2YUB5wpH4 (BA.5 bivalent was ~3-5X WT in several recent studies) https://t.co/xYwnfcXkm6

2022-11-18 18:44:04 How to improve science discovery and productivity? Not just about money (see graph below): funding fast, bets on talent/people, take risk, think big https://t.co/HEAXu2L87H by @greg_ip w/ @patrickc @tylercowen @pdhsu https://t.co/7O6qplOf9C

2022-11-18 18:01:46 @KMunoz46 Correct. That's why there's no good explanation

2022-11-18 17:44:15 RT @ElinSilveous: “Foreign rivals have raced ahead in approving long-awaited nasal-spray vaccines, including one invented in St. Louis, cre…

2022-11-18 17:27:39 Does going to @NFL games increase risk of Covid? https://t.co/UzghLiDCgT Interesting findings of an association in the 14-21 day postgame period when >

2022-11-18 16:57:29 If you'd like to boost your protection vs BQ.1.1, 2 new studies that back up the bivalent as the way to get that done https://t.co/wAoTyur6be https://t.co/fDF4KEyJAL https://t.co/FiBnQRxlMG

2022-11-18 16:52:03 US Covid genomics

2022-11-18 15:54:32 A systematic review of Covid vaccines for kids age 5 to 11 (30 studies) Effectiveness 75% vs hospitalization

2022-11-18 15:45:27 @TopherSpiro46 @AshishKJha46 I know, Topher. Absolutely no reason for refusal of Congress and failure to fund. Appreciate @ashishkjha's strong advocacy

2022-11-18 14:58:07 An explainer for why the US is not pursuing nasal vaccines. TLDR: there is no good explanation https://t.co/Ih6ypzOva7 by @benjmueller w/ @VirusesImmunity @florian_krammer

2022-11-18 05:38:35 @hola_jonathan Many thanks!

2022-11-18 05:37:46 @amuendelheim Thanks!

2022-11-18 05:10:48 I'll be here until the lights go out........ You can also find me @erictopol@mstdn.social and https://t.co/YllXWa0b4k https://t.co/5rfMlDkCdM

2022-11-18 03:51:13 @lainemartin1 Very appreciative of your note!

2022-11-18 03:33:22 Refers to BQ.1.1 (see blue arrow)

2022-11-18 03:32:12 New data for why a bivalent booster will help: "These data suggest the bivalent BA.4/5 vaccine is more immunogenic than the original ...vaccine against circulating Omicron sublineages, including BQ.1.1 that is becoming prevalent globally." https://t.co/wAoTyur6be Get boosted! https://t.co/j21g0bELIp

2022-11-18 00:42:08 By current variant growth advantage patterns, the next couple of months in the US will be BQ.1.x dominated. Bivalent boosters will help protect

2022-11-18 00:20:49 @WHCOS Nicely put, Ron. Thanks!

2022-11-18 00:20:19 RT @WHCOS: In simpler terms: Go get your new COVID vaccination now.

2022-11-18 00:06:48 What science forgot during the pandemic https://t.co/12ffbs3ZOF by @richardhorton1 @TheLancet https://t.co/aoJSA3dEco

2022-11-17 23:56:45 A new report confirms the immune escape of the BQ.1.1 variant, along with BA.4.6 &

2022-11-17 23:26:54 We still don't have a way to diagnosis chronic traumatic encephalopathy (CTE) in people who are alive, but may be getting closer https://t.co/SftRQR7TWD by @el_belson @NYTSports https://t.co/BTh6oXUxRg

2022-11-17 21:47:06 RT @rowlsmanthorpe: Long covid has wrecked my life It’s bad, very bad. But you knew that already I want to tell you a hopeful story. A st…

2022-11-17 19:37:27 @PraliNoisette I don't see any sign of that https://t.co/e7u7aZCfBZ

2022-11-17 19:12:51 To note https://t.co/y2qdjFrvDR

2022-11-17 19:11:30 75 years later we have chips with >

2022-11-17 18:08:47 BA.5, déjà vu https://t.co/eILO8PxIkY

2022-11-17 17:33:41 RT @linseymarr: You get a 2-for-1 with filtration. It removes virus from the air and PM2.5 that is associated with an increased risk of inf…

2022-11-17 17:28:45 RT @Aiims1742: Important #OpenAccess paper in @Cancer_Cell from @CharlesSwanton &

2022-11-17 17:09:54 Strong evidence that particulate matter air pollution (ambient PM2.5) increases the risk of Covid infection, a systematic analysis https://t.co/RueG44Hk2m @MonashUni https://t.co/kpREoqJVPi

2022-11-17 15:46:50 About 1 in 5 of us have an APOE4 gene variant, the #1 genetic risk factor for Alzheimer's disease. But the mechanism for brain injury was a mystery, now getting unraveled (cholesterol processing by oligodendrocytes) https://t.co/gIpGt0CA28 @nature https://t.co/hbmdpO6R3t https://t.co/4zFZIhUTCI

2022-11-17 01:27:50 @amitsurg Because they do. That's mostly related to the excess of rebound after Paxlovid

2022-11-17 00:58:05 We've (re-)learned a few important lessons from the Paxlovid rebound experience about randomized trials and real world evidence Reviewed here https://t.co/jmT9vIipg9

2022-11-16 19:46:41 The Paxlovid rebound story New data reviewed in the 16 November daily briefing of Ground Truths https://t.co/jmT9vIipg9

2022-11-16 17:48:15 The US Covid death rate (7-day average) drops below 300 for the first time since June 2022. Lowest since pandemic began was 222 in July 2021. https://t.co/Cze8bZgtVr https://t.co/uxGosRY1KO

2022-11-16 17:14:12 Immunotherapy can induce myocarditis but the mechanism has been poorly understood. A new report @nature today supports the culprit auto-antigen role of α-myosin and cytotoxic T-cells directed to it https://t.co/uPRUQBbkVh by @MargaretAxelrod @BalkoLab https://t.co/vWZP1IcW19

2022-11-16 16:37:07 Humidity (indoor, relative) is associated with outcomes of Covid infections, a population-based study in 121 countries https://t.co/dWMmyMfBSL https://t.co/hW7Jq1mhdo

2022-11-16 01:17:21 RT @PeterHotez: Important and well-conducted study by @EricTopol My take: even though rebound is real and significant, in my conversation…

2022-11-15 23:33:25 For the people pointing out that @POTUS, @CDCDirector and Tony Fauci all had Paxlovid rebound, that's why you do prospective, systematic studies. We've learned that "rebound" also occurs without Paxlovid and that anecdotes/twitter are not representative of the real world

2022-11-15 20:14:34 Each participant did rapid antigen testing every other day through day 15, symptom surveys through day 17, and are being followed for 6 months https://t.co/8bDtswdytR

2022-11-15 20:00:32 The event curves for Paxlovid treated compared with controls https://t.co/2ykeOuBUAX

2022-11-15 19:56:25 Our prospective Paxlovid rebound study with controls preprint is posted By symptoms: ~12% rebound (19% Pax vs 7% controls) By positive testing: ~5% rebound (14% Pax vs 9% controls) Much lower than many estimates https://t.co/czeGEYIJvA by @JayPandit @michaelmina_lab @ScrippsRTI

2022-11-15 19:45:43 Foundation #AI models come to science https://t.co/G7Xx31w1Of https://t.co/HNjVOs3J4I

2022-11-15 19:23:17 @Jdrodric12 that's right!

2022-11-15 18:47:56 @SarahWLaurence @ScrippsRTI Thank you!

2022-11-15 18:31:49 On a day when the world has reached about ~8 billion people, it's notable there have been >

2022-11-15 17:10:19 @surrogateexpare @Medscape Included here https://t.co/bugfFk44sh@Medscape Please fix the links

2022-11-15 17:09:38 This post has all the relevant links and review the recent its for protection vs #LongCovid https://t.co/bugfFk44sh

2022-11-15 16:30:20 Paxlovid interactionsA new report claims 14.6% of patients had contraindications to treatment. But most of these meds could have been safely stopped for 5 dayshttps://t.co/FP3o0J0eBzMore on this herehttps://t.co/i3pUyAJlAs @Medscape https://t.co/0tsAf3xUqu

2022-11-15 16:11:35 Start of new waves in South Korea and Japan, having sustained recent BA.5 waves and this variant still accounts for most new casesThe pandemic isn't over https://t.co/DhwWhZ4CJi

2022-11-15 16:01:28 Here's the article. A potential path to preventing brain tissue from dying https://t.co/ODGuD8X8iy

2022-11-15 00:48:03 Today's pandemic briefing on new booster data and the thick soup of new variantshttps://t.co/LA3nl6FxSx

2022-11-14 17:22:13 RT @danrdanny: Excited to see our work on 3-hour genome sequencing highlighted here! If you think this is interesting we have a bench scien…

2022-11-14 17:04:44 The potential for detecting heart dysfunction (ejection fraction <

2022-11-14 14:37:14 RT @EricTopol: Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so m…

2022-11-14 14:28:16 In aggregate, solid evidence that the bivalent booster elicits a strong and broadened neutralizing antibody immune response. Yet, less than 27% of Americans 65+, the have had it and poor uptake across all age groupshttps://t.co/V5Xlj3cKln

2022-11-14 14:28:15 https://t.co/fJbLUdcYJdCoverage @statnews by @matthewherper w/ @SutharLab, whose results were replicated by the new data (Table)

2022-11-14 12:00:01 Moderna BA.5 bivalent booster results announced (via @moderna_tx press release)—largest study to date of >

2022-12-07 20:33:05 "But over the last 30 years or so, I have begun to realize that while RCTs are a brilliant idea for testing drugs, they are a catastrophically bad idea for testing certain other things, masks being one of them."—@trishgreenhalgh https://t.co/IaVXavjlC7 w/ transcript

2022-12-07 19:37:31 @JReinerMD Thanks Jonathan!

2022-12-07 18:54:30 The last time Covid hospital admissions in New York State was this high was in early February 2022 https://t.co/vw77IAyHJj https://t.co/Zwy5b2byHT

2022-12-07 18:50:25 RT @EricTopol: The body of evidence we have for efficacy and safety of Covid vaccines is the largest in the history of medical interventions

2022-12-07 17:59:57 The rise in US Covid hospitalizations may surpass the summer BA.5 wave, fueled by waning immunity, lack of mitigation and BQ.1.1 https://t.co/o5ibW11jaX https://t.co/Y3Uf6EKC3i

2022-12-07 16:07:37 @JillianHortonMD Thank you!

2022-12-07 15:50:42 The denialism of a new wave extends to the risk of infections and reinfections. "Anyone who doesn’t take seriously the risk of COVID infection is in denial about the risk of #LongCovid and its potentially disabling effects."

2022-12-07 15:40:23 During COVID-19, the US lost more life expectancy than almost any other country as assessed here, #dataviz https://t.co/DIxN3ZrvsK @NatureHumBehav @FortuneMagazine by @Trans_World https://t.co/HSx8SprqVN

2022-12-07 15:27:34 Los Angeles County is the largest county in the US with a population of nearly 10 million people Now with a new Covid surge https://t.co/EM7Ei3cpGB @LukeMMoney @ronlin Cases have doubled and hospitalizations are up 77% in the last 2 weeks https://t.co/2hpenSZ59k https://t.co/xXBiuekLJi

2022-12-07 15:18:44 Much can be done to limit the new Covid wave....that isn't being done. https://t.co/cXxjLDiX3e @latimes my oped @latimesopinion https://t.co/JHQh2odOyG

2022-12-07 14:15:25 The body of evidence we have for efficacy and safety of Covid vaccines is the largest in the history of medical interventions

2022-12-07 23:26:54 France is the 1st country to have seen the BQ.1.1 variant become dominant (now >

2022-12-07 23:11:37 Characterization of the immune evasion and cell entry for the new variants: BQ.1.1, XBB.1, and BR.2.1 (<

2022-12-07 20:33:05 "But over the last 30 years or so, I have begun to realize that while RCTs are a brilliant idea for testing drugs, they are a catastrophically bad idea for testing certain other things, masks being one of them."—@trishgreenhalgh https://t.co/IaVXavjlC7 w/ transcript

2022-12-07 19:37:31 @JReinerMD Thanks Jonathan!

2022-12-07 18:54:30 The last time Covid hospital admissions in New York State was this high was in early February 2022 https://t.co/vw77IAyHJj https://t.co/Zwy5b2byHT

2022-12-07 18:50:25 RT @EricTopol: The body of evidence we have for efficacy and safety of Covid vaccines is the largest in the history of medical interventions

2022-12-07 17:59:57 The rise in US Covid hospitalizations may surpass the summer BA.5 wave, fueled by waning immunity, lack of mitigation and BQ.1.1 https://t.co/o5ibW11jaX https://t.co/Y3Uf6EKC3i

2022-12-07 16:07:37 @JillianHortonMD Thank you!

2022-12-07 15:50:42 The denialism of a new wave extends to the risk of infections and reinfections. "Anyone who doesn’t take seriously the risk of COVID infection is in denial about the risk of #LongCovid and its potentially disabling effects."

2022-12-07 15:40:23 During COVID-19, the US lost more life expectancy than almost any other country as assessed here, #dataviz https://t.co/DIxN3ZrvsK @NatureHumBehav @FortuneMagazine by @Trans_World https://t.co/HSx8SprqVN

2022-12-07 15:27:34 Los Angeles County is the largest county in the US with a population of nearly 10 million people Now with a new Covid surge https://t.co/EM7Ei3cpGB @LukeMMoney @ronlin Cases have doubled and hospitalizations are up 77% in the last 2 weeks https://t.co/2hpenSZ59k https://t.co/xXBiuekLJi

2022-12-07 15:18:44 Much can be done to limit the new Covid wave....that isn't being done. https://t.co/cXxjLDiX3e @latimes my oped @latimesopinion https://t.co/JHQh2odOyG

2022-12-07 14:15:25 The body of evidence we have for efficacy and safety of Covid vaccines is the largest in the history of medical interventions

2022-12-08 22:03:27 China's elders problem https://t.co/3TcJQYrFul https://t.co/uG4zedUfuK

2022-12-08 21:43:12 Comparison of ChatGPT and AlphaCode https://t.co/QjlEMViyOT

2022-12-08 21:41:13 @richardludlow @NatureMedicine @ma_hamer @M_Stamatakis No cause and effect established or asserted

2022-12-08 19:46:05 RT @hholdenthorp: Enjoyed talking to Tony Fauci about the last few years and what lies ahead. Lots of great stuff in here for science polic…

2022-12-08 19:22:32 No problem, I'll code for you #AlphaCode https://t.co/7m41MgwHUM "This result marks the 1st time an #AI system has performed competitively in programming competitions" @DeepMind @OriolVinyalsML Not so fast. What it can and can't do. https://t.co/lasA1mJK08 by @zicokolter https://t.co/QqRYL14VJh

2022-12-08 18:40:15 Why does having a human cell atlas, with single-cell and spatial definition, have such transformative potential in medicine? https://t.co/l1II0q1was by @jennyErood @AidMaart @teichlab @GraphicAnja Aviv Regev @NatureMedicine https://t.co/0ZSvKnYaMg

2022-12-08 18:29:52 @JeremyKonyndyk Thanks Jeremy!

2022-12-08 17:36:09 1 vs 3 , a 3-fer https://t.co/ik98DuHT76 by @AlexLJanin w/ @dr_kkjetelina https://t.co/jZnusaUtxA @taraparkerpope @FenitN https://t.co/MyRvFSqD2G

2022-12-08 16:51:44 The conclusion is worth reviewing —1 minute bursts, 3 to 4 per day —for non-exercisers, there's hope —these finding only possible via ~25,000 people from @uk_biobank, wearable sensors, and #AI analytics —1st research to measure VILPA effects https://t.co/ECoOUmaaOo

2022-12-08 16:45:19 @paulg @NatureMedicine @ma_hamer @M_Stamatakis Yes, correct. 1 minute bursts made a difference, 3-4 per of these per day associated with the protection

2022-12-08 16:34:59 Vigorous intermittent lifestyle physical activity (VILPA), 3-4 minute bursts per day, associated with ~40% reduction of all-cause mortality, cancer and cardiovascular mortality https://t.co/BoGmigjqWl @NatureMedicine @ma_hamer @M_Stamatakis https://t.co/UPx61oh4Gs

2022-12-08 16:19:41 Subsequent development of #LongCovid detected by gene expression during acute infection. Two different patterns related to antibody production to spike protein https://t.co/ZklAmwyk4L @NatureMedicine @noambeckmann1 @IcahnMountSinai https://t.co/7uklWADq7e

2022-12-08 15:18:00 RT @Yale: PODCAST: @thehowie and @hmkyale are joined by Dr. Eric Topol, a physician and writer to discuss his career turn toward genomics a…

2022-12-07 23:26:54 France is the 1st country to have seen the BQ.1.1 variant become dominant (now >

2022-12-07 23:11:37 Characterization of the immune evasion and cell entry for the new variants: BQ.1.1, XBB.1, and BR.2.1 (<

2022-12-07 20:33:05 "But over the last 30 years or so, I have begun to realize that while RCTs are a brilliant idea for testing drugs, they are a catastrophically bad idea for testing certain other things, masks being one of them."—@trishgreenhalgh https://t.co/IaVXavjlC7 w/ transcript

2022-12-07 19:37:31 @JReinerMD Thanks Jonathan!

2022-12-07 18:54:30 The last time Covid hospital admissions in New York State was this high was in early February 2022 https://t.co/vw77IAyHJj https://t.co/Zwy5b2byHT

2022-12-07 18:50:25 RT @EricTopol: The body of evidence we have for efficacy and safety of Covid vaccines is the largest in the history of medical interventions

2022-12-07 17:59:57 The rise in US Covid hospitalizations may surpass the summer BA.5 wave, fueled by waning immunity, lack of mitigation and BQ.1.1 https://t.co/o5ibW11jaX https://t.co/Y3Uf6EKC3i

2022-12-07 16:07:37 @JillianHortonMD Thank you!

2022-12-07 15:50:42 The denialism of a new wave extends to the risk of infections and reinfections. "Anyone who doesn’t take seriously the risk of COVID infection is in denial about the risk of #LongCovid and its potentially disabling effects."

2022-12-07 15:40:23 During COVID-19, the US lost more life expectancy than almost any other country as assessed here, #dataviz https://t.co/DIxN3ZrvsK @NatureHumBehav @FortuneMagazine by @Trans_World https://t.co/HSx8SprqVN

2022-12-07 15:27:34 Los Angeles County is the largest county in the US with a population of nearly 10 million people Now with a new Covid surge https://t.co/EM7Ei3cpGB @LukeMMoney @ronlin Cases have doubled and hospitalizations are up 77% in the last 2 weeks https://t.co/2hpenSZ59k https://t.co/xXBiuekLJi

2022-12-07 15:18:44 Much can be done to limit the new Covid wave....that isn't being done. https://t.co/cXxjLDiX3e @latimes my oped @latimesopinion https://t.co/JHQh2odOyG

2022-12-07 14:15:25 The body of evidence we have for efficacy and safety of Covid vaccines is the largest in the history of medical interventions

2022-12-08 22:03:27 China's elders problem https://t.co/3TcJQYrFul https://t.co/uG4zedUfuK

2022-12-08 21:43:12 Comparison of ChatGPT and AlphaCode https://t.co/QjlEMViyOT

2022-12-08 21:41:13 @richardludlow @NatureMedicine @ma_hamer @M_Stamatakis No cause and effect established or asserted

2022-12-08 19:46:05 RT @hholdenthorp: Enjoyed talking to Tony Fauci about the last few years and what lies ahead. Lots of great stuff in here for science polic…

2022-12-08 19:22:32 No problem, I'll code for you #AlphaCode https://t.co/7m41MgwHUM "This result marks the 1st time an #AI system has performed competitively in programming competitions" @DeepMind @OriolVinyalsML Not so fast. What it can and can't do. https://t.co/lasA1mJK08 by @zicokolter https://t.co/QqRYL14VJh

2022-12-08 18:40:15 Why does having a human cell atlas, with single-cell and spatial definition, have such transformative potential in medicine? https://t.co/l1II0q1was by @jennyErood @AidMaart @teichlab @GraphicAnja Aviv Regev @NatureMedicine https://t.co/0ZSvKnYaMg

2022-12-08 18:29:52 @JeremyKonyndyk Thanks Jeremy!

2022-12-08 17:36:09 1 vs 3 , a 3-fer https://t.co/ik98DuHT76 by @AlexLJanin w/ @dr_kkjetelina https://t.co/jZnusaUtxA @taraparkerpope @FenitN https://t.co/MyRvFSqD2G

2022-12-08 16:51:44 The conclusion is worth reviewing —1 minute bursts, 3 to 4 per day —for non-exercisers, there's hope —these finding only possible via ~25,000 people from @uk_biobank, wearable sensors, and #AI analytics —1st research to measure VILPA effects https://t.co/ECoOUmaaOo

2022-12-08 16:45:19 @paulg @NatureMedicine @ma_hamer @M_Stamatakis Yes, correct. 1 minute bursts made a difference, 3-4 per of these per day associated with the protection

2022-12-08 16:34:59 Vigorous intermittent lifestyle physical activity (VILPA), 3-4 minute bursts per day, associated with ~40% reduction of all-cause mortality, cancer and cardiovascular mortality https://t.co/BoGmigjqWl @NatureMedicine @ma_hamer @M_Stamatakis https://t.co/UPx61oh4Gs

2022-12-08 16:19:41 Subsequent development of #LongCovid detected by gene expression during acute infection. Two different patterns related to antibody production to spike protein https://t.co/ZklAmwyk4L @NatureMedicine @noambeckmann1 @IcahnMountSinai https://t.co/7uklWADq7e

2022-12-08 15:18:00 RT @Yale: PODCAST: @thehowie and @hmkyale are joined by Dr. Eric Topol, a physician and writer to discuss his career turn toward genomics a…

2022-12-07 23:26:54 France is the 1st country to have seen the BQ.1.1 variant become dominant (now >

2022-12-07 23:11:37 Characterization of the immune evasion and cell entry for the new variants: BQ.1.1, XBB.1, and BR.2.1 (<

2022-12-07 20:33:05 "But over the last 30 years or so, I have begun to realize that while RCTs are a brilliant idea for testing drugs, they are a catastrophically bad idea for testing certain other things, masks being one of them."—@trishgreenhalgh https://t.co/IaVXavjlC7 w/ transcript

2022-12-07 19:37:31 @JReinerMD Thanks Jonathan!

2022-12-07 18:54:30 The last time Covid hospital admissions in New York State was this high was in early February 2022 https://t.co/vw77IAyHJj https://t.co/Zwy5b2byHT

2022-12-07 18:50:25 RT @EricTopol: The body of evidence we have for efficacy and safety of Covid vaccines is the largest in the history of medical interventions

2022-12-07 17:59:57 The rise in US Covid hospitalizations may surpass the summer BA.5 wave, fueled by waning immunity, lack of mitigation and BQ.1.1 https://t.co/o5ibW11jaX https://t.co/Y3Uf6EKC3i

2022-12-07 16:07:37 @JillianHortonMD Thank you!

2022-12-07 15:50:42 The denialism of a new wave extends to the risk of infections and reinfections. "Anyone who doesn’t take seriously the risk of COVID infection is in denial about the risk of #LongCovid and its potentially disabling effects."

2022-12-07 15:40:23 During COVID-19, the US lost more life expectancy than almost any other country as assessed here, #dataviz https://t.co/DIxN3ZrvsK @NatureHumBehav @FortuneMagazine by @Trans_World https://t.co/HSx8SprqVN

2022-12-07 15:27:34 Los Angeles County is the largest county in the US with a population of nearly 10 million people Now with a new Covid surge https://t.co/EM7Ei3cpGB @LukeMMoney @ronlin Cases have doubled and hospitalizations are up 77% in the last 2 weeks https://t.co/2hpenSZ59k https://t.co/xXBiuekLJi

2022-12-07 15:18:44 Much can be done to limit the new Covid wave....that isn't being done. https://t.co/cXxjLDiX3e @latimes my oped @latimesopinion https://t.co/JHQh2odOyG

2022-12-07 14:15:25 The body of evidence we have for efficacy and safety of Covid vaccines is the largest in the history of medical interventions

2022-12-09 04:46:21 @msb1iop @paulg @NatureMedicine @ma_hamer @M_Stamatakis Thanks. I didn't delete anything

2022-12-08 22:03:27 China's elders problem https://t.co/3TcJQYrFul https://t.co/uG4zedUfuK

2022-12-08 21:43:12 Comparison of ChatGPT and AlphaCode https://t.co/QjlEMViyOT

2022-12-08 21:41:13 @richardludlow @NatureMedicine @ma_hamer @M_Stamatakis No cause and effect established or asserted

2022-12-08 19:46:05 RT @hholdenthorp: Enjoyed talking to Tony Fauci about the last few years and what lies ahead. Lots of great stuff in here for science polic…

2022-12-08 19:22:32 No problem, I'll code for you #AlphaCode https://t.co/7m41MgwHUM "This result marks the 1st time an #AI system has performed competitively in programming competitions" @DeepMind @OriolVinyalsML Not so fast. What it can and can't do. https://t.co/lasA1mJK08 by @zicokolter https://t.co/QqRYL14VJh

2022-12-08 18:40:15 Why does having a human cell atlas, with single-cell and spatial definition, have such transformative potential in medicine? https://t.co/l1II0q1was by @jennyErood @AidMaart @teichlab @GraphicAnja Aviv Regev @NatureMedicine https://t.co/0ZSvKnYaMg

2022-12-08 18:29:52 @JeremyKonyndyk Thanks Jeremy!

2022-12-08 17:36:09 1 vs 3 , a 3-fer https://t.co/ik98DuHT76 by @AlexLJanin w/ @dr_kkjetelina https://t.co/jZnusaUtxA @taraparkerpope @FenitN https://t.co/MyRvFSqD2G

2022-12-08 16:51:44 The conclusion is worth reviewing —1 minute bursts, 3 to 4 per day —for non-exercisers, there's hope —these finding only possible via ~25,000 people from @uk_biobank, wearable sensors, and #AI analytics —1st research to measure VILPA effects https://t.co/ECoOUmaaOo

2022-12-08 16:45:19 @paulg @NatureMedicine @ma_hamer @M_Stamatakis Yes, correct. 1 minute bursts made a difference, 3-4 per of these per day associated with the protection

2022-12-08 16:34:59 Vigorous intermittent lifestyle physical activity (VILPA), 3-4 minute bursts per day, associated with ~40% reduction of all-cause mortality, cancer and cardiovascular mortality https://t.co/BoGmigjqWl @NatureMedicine @ma_hamer @M_Stamatakis https://t.co/UPx61oh4Gs

2022-12-08 16:19:41 Subsequent development of #LongCovid detected by gene expression during acute infection. Two different patterns related to antibody production to spike protein https://t.co/ZklAmwyk4L @NatureMedicine @noambeckmann1 @IcahnMountSinai https://t.co/7uklWADq7e

2022-12-08 15:18:00 RT @Yale: PODCAST: @thehowie and @hmkyale are joined by Dr. Eric Topol, a physician and writer to discuss his career turn toward genomics a…