Eric J. Topol, is an American cardiologist, geneticist and digital medicine researcher.
He contributed to the discussions that set up the AI deeplearning courses for medicine with expert Andrew Ng.
Eric wrote a book called "Deep Medicine" which gives an attractive view of AI in the medical field.
He thinks in particular that the development of the iA which provides "ambient intelligence" will totally transform medicine.
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2025-01-10 18:54:00 Digitizing the human proteome in >
2025-01-10 18:36:44 Two new reports on T cells and viral infections —more Tregs and enhanced protection via multiple Covid booster shots https://t.co/uM0hjJ8RUg —a vaccine's ability to prevent infections without neutralizing antibodies @NatureMicrobiol https://t.co/l5slObqABjhttps://t.co/WxM9lrNR1f
2025-01-10 17:54:23 Combining GLP-1 and insulin for Type 1 diabetes: a small randomized trial showed reduced insulin need, less carbohydrate intake, better glucose regulation, and reduced body weight https://t.co/1sdQq5DNmS @NatureMedicine
2025-01-09 18:00:14 @CzypionkaThomas @CellCellPress @ScienceMagazine Good point. I think the answer to your last question is yes.
2025-01-09 17:06:58 New evidence on ultra-processed foods (UPF) from prospective assessment throughout 9 countries in Europe "Higher UPF consumption was associated with greater mortality from circulatory diseases, digestive diseases, and Parkinson’s disease." https://t.co/j4DWTGbhNjhttps://t.co/OYoSRVjvDEhttps://t.co/kZWjjnHkEF
2025-01-06 02:51:19 @joybeingfree99 Thank you!
2025-01-05 18:28:39 Mosaic pattern loss of Y chromosome, which occurs in ~40% of men by age 70, is causally linked to heightened risk of many diseases, including cardiovascular, bladder cancer, and Alzheimer's. But it's almost never assessed clinically. A new @NatureRevGenet https://t.co/BUoC3V6h4Hhttps://t.co/QMMlnCoyurhttps://t.co/7v5IGHRDAo
2025-01-05 17:23:22 In randomized clinical trials, 10 people out of 100 might derive benefit (<
2025-01-05 16:51:54 RT @EricTopol: The scientist who is responsible for driving GLP-1 drugs for the treatment of obesity and testing them for prevention of Alz…
2025-01-05 16:21:38 The world's oldest person died at age 116. https://t.co/9DOnKocHgb Longest human life recorded is Jeanne Calment who died in 1997 at age 122 https://t.co/TdPRVTFmgq
2024-12-31 22:28:49 The severe case in Louisiana (first in US) is not included in these reports https://t.co/w0bXjkGQCC While the risk of human-to-human transmission is still low, the pervasive reservoirs and appearance of new, concerning mutations or those identified as a threat… https://t.co/cEGAdUkRPYhttps://t.co/2osVdSwXA3
2024-12-31 22:00:20 3. Review of 46 cases of mild H5N1 illness by CDC in 2024 https://t.co/8iGCcmI2bF
2024-12-31 22:00:19 2. Report of the 13-year-old Canadian girl who developed acute respiratory failure. Sequence of her H5N1 revealed 3 mutations that may be linked to higher virulence and adaptation to human cell binding https://t.co/vawzzo39Kb
2024-12-31 22:00:18 Three new @NEJM reports on #H5N1 today 1. An overview by @MichaelGIsonMD and @DrJeanneM "urgent need for vigilant surveillance of emerging mutations and assessment of the threat of human-to-human transmission" https://t.co/wr1oy1E5Qk
2024-12-29 19:53:08 Do you know about PIEZO receptors? We're learning more about their expansive role every day. A new podcast (with transcript and full video) with @ardemp , my friend and colleague @scrippsresearch, who discovered these channels In Ground Truths, see my profile for the link.… https://t.co/j30Vp8dhRVhttps://t.co/RDA9PYtkjs
2024-12-28 19:10:46 On "Face Age" >
2024-12-24 16:09:11 The potential for using continuous glucose sensors and #AI to differentiate types of glucose dysregulation in people with Type 2 diabetes or pre-diabetes https://t.co/wHk2CtLdmL @NatBME @Snyder_Lab_SU
2024-12-24 15:24:08 Covid is associated with an increased risk of Type 2 diabetes https://t.co/RoxbXcgLDV (one of many reports) But the mechanism is unclear. A new study suggests islet microvascular dysfunction is a contributing factor https://t.co/zZIUIlVDoI open-access https://t.co/gt8hWTH7w8
2024-12-24 15:02:21 A.I. as unlocking life’s deepest secrets and establishing a powerful new basis for curing ills, improving health and lengthening lives. "Once we decipher and truly understand the language of life, it will be magical."—@pushmeet
2024-12-23 22:31:47 Anticoagulation for severe (hospitalized) Covid, a prospective, systematic review https://t.co/CL6qtTqqCC Supports therapeutic levels (vs prophylactic) to improve survival but lots of nuances @AnnalsofIM https://t.co/GUK5ZLRydP
2024-12-23 18:58:20 Good summary of this important advance in a 25-year-old woman with Type 1 diabetes ->
2024-12-23 15:37:35 Spatial omics of human arteries to understand what drives atherosclerosis: highlights role of the microvasculature (vasa vasorum), adventitial inflammation, migration of vascular smooth muscle cells (and more) https://t.co/rFQROipzPe @NatureCVR @sikandhayat @rkramann https://t.co/LAoAMHOE9F
2024-12-21 16:57:39 The 3 big PBMs owned by insurance companies, each with a group purchasing organization, control 80% of US prescriptions https://t.co/83LlnqORPT
2024-12-19 19:28:46 good metaphor to explain opening up extra registers at the coffee shop during rush hour https://t.co/ACJOBhdTOF
2024-12-19 19:28:45 How to improve memory and cognitive function in aged mice Fix the mitochondrial EC (excitation-coupling) @ScienceMagazine https://t.co/DDQkPiDsYP representing a new potential path for replenishing neuronal energy reserves to counter brain aging https://t.co/7N7PsuScAN
2024-12-19 13:59:24 Complementing other biological clocks (epigenetic, proteomic) metabolomics helps predict health and lifespan. From 168 metabolites in >
2024-12-19 13:22:02 Related: The vagus nerve's prominent role in brain-gut, brain-immune system, brain-body interactions https://t.co/4NTWiUmYr1 @sciam @jenapincott open-access https://t.co/h1ETImNMG2
2024-12-17 16:17:23 "Why does the brain need billions of neurons to process 10 bits/second? Why can we only think about one thing at a time?" by @jieyusz and @mameister4 @Caltech @NeuroCellPress https://t.co/5QMHIXoX4Hhttps://t.co/7CtNlXCPZE
2024-12-17 15:25:48 Unsupervised deep learning of gene expression patterns across 18 types of cancer reveals insights on immune pathways and clinical outcomes https://t.co/eBEXDfFqoX @natBME @suinleelab
2024-12-15 21:45:08 @DocBorelli Yes. On Amazon for preorder
2024-12-15 21:44:43 @greenbranch @simonschuster and great!
2024-12-15 21:43:18 @SeigoIzumo Yes, I am doing the audio version (finally) of this book. Thanks, Segio
2024-12-15 18:04:07 @lightseeker22 Exactly!
2024-12-15 17:33:47 @haydentiff Thanks! Reduction in MCHC setpoint, less progression to Type 2 diabetes and MCHC percentile associated with major cardiovascular events (MACE) https://t.co/3lB4P9Emdd
2024-12-13 18:08:51 From Nature's top 2024 photos https://t.co/joGaE7oiBU I like this one, standing on the shoulders of giants
2024-12-13 00:23:37 @DocJeffD @PCORI They said there wasn’t enough proof (prelim data) that they’d work!
2024-12-12 19:51:28 The fate of T cells, such as seen in exhausted T cells, is tied to nutrients. This introduces the potential of therapies directed at keeping T cell identity and function intact. (And the infamous Krebs cycle makes a comeback to my brain) https://t.co/6Dv1Cbqxg2 @ScienceMagazine… https://t.co/Vueqa0bNzY
2024-12-12 19:17:34 The capability for producing "mirror life" is out there and poses danger. When some scientists who worked on this became aware, they stopped pursuing it, and co-authored this piece, along with over 30 leading scientists—a @ScienceMagazine policy forum that lays out the risks… https://t.co/aW82Fwz8qHhttps://t.co/T53bIzbRYh
2024-12-12 01:03:40 RT @EricTopol: New @nature Our blood tests are interpreted by average reference values. That's missing a lot or rich information! Each per…
2024-12-11 22:56:57 Wouldn't have guessed that a PCSK9 blocker (used for LDL cholesterol lowering) might someday be indicated to prevent breast cancer in individuals with a common genomic variant https://t.co/Vxc2oIhNgLhttps://t.co/ctWzxK623r
2024-12-11 19:44:20 Predicting clotting events in 49 of 53 people with Covid. An immunosensor that rapidly detects 4 different protein biomarkers https://t.co/kSuYo7qk7z @ScienceAdvances https://t.co/ksHpBpKNZj
2024-12-11 18:54:19 Whenand vomit make the cover
2024-12-09 22:26:10 With more layers of data, our ability to predict a person's risk of heart disease is getting better and better https://t.co/BI0ltvTodY @AnnalsofIM adding in social determinants of health, lifestyle, and other data @iftikhar_kullo @uk_biobank https://t.co/ng3i7nWCDY
2024-12-09 20:56:11 RT @EricTopol: We're learning how to control the immune response, like a rheostat, even in the brain. Implications for understanding the ba…
2024-12-09 16:49:34 Huji Xu recognized by @Nature as a top 10 who shaped science in 2024 Off-the-shelf CAR-T cells (CD-19 directed) for treating severe refractory autoimmune diseases. https://t.co/ybMsMmfbJ5https://t.co/nivCFJpkCi
2024-12-09 16:00:11 Link to paper https://t.co/1WVgBiPAAK This is part of the high-throughput proteomics revolution with #AI analytics that is yielding new insights about the aging process, organ clocks, and much more I wrote about it @ScienceMagazine https://t.co/LGkHiPR4Rt
2024-12-09 16:00:10 2. The protein brevican (BCAN) was strongly associated with brain age gap, MRI structural changes, dementia (all-cause, ACD, and Alzheimer's AD), stroke and movement functions, and Mendelian randomization supported causality https://t.co/7YID4p9y9whttps://t.co/E2KkI67Ld4
2024-12-07 15:04:12 The David Sinclair anti-aging companies story, front page WSJ https://t.co/xevWnbXbgp "Follow scientists who say Sinclair tends to exaggerate the findings and implications of age-related research, tarnishing a nascent field vying for credibility" https://t.co/MUba9ispDC
2024-12-06 16:06:30 RT @TwistBioscience: “Are we now entering an exponential phase of digital biology, a vertical takeoff, a golden age of discovery?” -@EricTo…
2024-12-06 15:34:00 The XEC variant continues to show growth advantage in the latest US genomic SARS-CoV-2 surveillance, accounting for 44% of new cases https://t.co/jjl2AnOYb5https://t.co/aqW4ni4m3p
2024-12-05 20:55:36 Quite an innovation! Continuous real-time monitoring of inflammation and protein biomarkers in the body with a shaking sensor https://t.co/oHaPVWwQfI @ScienceMagazine @HZargartalebi @NorthwesternU @czbiohub https://t.co/xjYEIvx2yo
2024-12-03 01:23:34 @RendAlKhalili Very kind of you!
2024-12-03 01:22:11 @drfeifei @theworldlabs Congratulations on this rapid and formidable progress, Fei-Fei and @theworldlabs team!
2024-12-03 01:02:57 @sdorodgar Thanks very much
2024-12-02 21:50:57 "Ketone bodies are janitors of damaged proteins, chaperoning away molecular waste so organisms can operate at peak molecular fitness." as demonstrated in multiple experimental Alzheimer's and aging models https://t.co/qxRwiI9KSO @BuckInstitute
2024-12-02 20:47:25 Strong new evidence for T cell exhaustion in myalgic encephalomyelitis (ME/CFS) reflecting chronic viral infection, relevant to #LongCovid, and possible path to treatment candidates https://t.co/HmcYbINPuR @PNASNews https://t.co/gHOFyLfAg9
2024-11-30 23:40:30 RT @EricTopol: A vertical takeoff of life science with #AI LLLMs. Publication of 10 new foundation models of Proteins, DNA, RNA, methylatio…
2024-11-30 20:46:40 What should we eat? Or avoid? The new Ground Truths podcast is with Kevin Hall (@KevinH_PhD), a leading scientist in nutrition and metabolism @NIH Transcript with links to his many recent publications. Open-access, free, no ads. Link is in the photo below and in my profile. https://t.co/0J5Cy5LU6S
2024-11-30 19:45:18 With all the revisionist history, this early 2021 debate seems relevant https://t.co/SfES1Dzt2F
2024-11-30 14:53:05 PIEZO ion channels are to human physiology as GLP-1 drugs are to treating many diseases https://t.co/OsLKveLhpY @ScienceMagazine
2024-11-28 21:33:13 RT @AI_4_Healthcare: If you only read one #AInHealthcare post-article-link this week, @EricTopol has written your script and the dispensing…
2024-11-28 20:49:44 I stand by my posts on this topic from over a year ago (now 4+ years instead of 3+). https://t.co/ZwR5TRorLT
2024-11-28 20:29:16 Blood vessel wall (endothelial) inflammation as a key to multi-organ complications of Covid and #LongCovid @ScienceMagazine w/ @ScienceVisuals https://t.co/I316bJ1D0Ihttps://t.co/0t7SKWmzCN
2024-11-26 21:20:16 A weak article @TheEconomist on the dangers of ultra-processed foods. The subtitle is "a mystery is finally being solved" yet there is nothing in the piece that advances our knowledge...just that they're working on it! https://t.co/qIB2IHMqU4https://t.co/bpMaYxEr1khttps://t.co/5444Mf8pLB
2024-11-25 23:57:43 RT @BoWang87: This is amazing article! Thanks @EricTopol for highlighting two of our new foundation models for DNA methylation!
2024-11-25 22:07:25 The journal @Nature asked 6 biomedical scientists to briefly comment on what should be a U.S. priority going forward. Here's mine https://t.co/zS5oUbb1Behttps://t.co/N3A1k1RTaM
2024-11-23 19:00:28 RT @GoogleDeepMind: How can AI revolutionize the scientific method to bring in a new age of discovery? @EricTopol chaired a fascinating di…
2024-11-23 15:31:57 How well do vaccines protect vs #LongCovid, a systematic review during the Omicron era? —about 20% reduced by primary series (vs no vaccination), and —another 20% reduction by boosters vs primary series https://t.co/FMk4Z4W3cPhttps://t.co/Pq8fb3GZpQ
2024-11-23 14:54:43 Misdiagnosis The author underwent a cardiac CT scan showing a very high score for calcium and was assigned the diagnosis of coronary artery disease. But it turned out he had sitostoleremia, a rare genetic disease, with a very different management plan https://t.co/s95XWSVV8Whttps://t.co/iA0SyDTvre
2024-11-22 00:25:57 They're coming fast and furious! Also today @ScienceMagazine add EVOLVEpro, a protein large language model combined with a regression model, for genome editing, antibody binding and more applications for evolving proteins https://t.co/V4BLfkg5lP @omarabudayyeh @jgooten @idmjky… https://t.co/cn9F57zLbX
2024-11-22 00:09:17 Health inequities in the United States keep getting worse. There are 10 Americas as shown below, with stark reduction (widening gaps) of life expectancy https://t.co/dm1Nf8cfBF @TheLancet @IHME_UW https://t.co/lTg0dPGYUU
2024-11-21 21:07:30 RT @pushmeet: It was a pleasure to be part of @GoogleDeepMind’s first-ever AI for Science Forum. A highlight was joining this panel with @E…
2024-11-21 19:23:02 There's really no such thing as "blue zones" for longevity https://t.co/XhKfoKuAIU @NewsfromScience @ScienceMagazine open-access feature by @IgnacioAmigoH
2024-11-19 12:47:31 Definition of the brain circuitry that slows breathing during emotional stress or anxiety @salkinstitute @justsaysinmice @NatureNeuro https://t.co/GDwkGAlNuf
2024-11-19 10:24:28 which would also drive rebound weight gain after GLP-1 drug discontinuation
2024-11-18 18:32:16 In 23 countries, among >
2024-11-18 16:13:24 New @Nature A mechanism for why durable weight loss is so difficult: epigenetic memory of fat cells https://t.co/bfyTkvWS1P @vonMeyenn @laurahinte https://t.co/6NjAP0n366
2024-11-18 13:54:18 There are now 5 reports like this—#AI performing better than physicians + AI—and we don’t have the explanation for why yet (hybrid was supposed to be best) Gift link https://t.co/wS0MH3X21Fhttps://t.co/GB1gQ24DIu
2024-11-17 15:47:53 RT @EricTopol: Time for some laughter medicine With the Glaucomfleckens @DGlaucomflecken @LGlaucomflecken In the new Ground Truths podcast…
2024-11-16 23:59:02 So proud of you, Oussama, for leading this impactful trial, getting the answer to such an important dangling question
2024-11-16 23:52:49 @SolidEvidence Since Election Day -17K here, +17K at Bluesky
2024-11-16 23:21:20 @MaxineMann52216 @NEJM @omwazni yes it does!
2024-11-16 00:42:30 @SolidEvidence Thanks Marc. That’s about right. All since the election. They’re leaving in droves and it’s not bots. I’ll keep posting here (never give up) but will be showing up much more on Substack Ground Truths (notes, analyses, and podcast) and Bluesky
2024-11-15 17:24:21 @EcoSexuality @ScienceMagazine Yes, I am there @erictopol.bsky.social
2024-11-15 16:55:25 RT @JMRothberg: What a week for biology!! Can’t wait to plug #Evo into @james_y_zou #virtuallab. @impossiblevines @ProteinEvo Thanks @…
2024-11-15 15:46:16 RT @EricTopol: How engineered T cells are changing the face of autoimmune diseases via B cell depletion https://t.co/yREY9OSeyY @ScienceMa…
2024-11-14 02:16:23 RT @EricTopol: New @NEJM A whopping (~90%) reduction of progression to Type 2 diabetes with tirzepatide (GLP-1 drug, dual receptor) vs pla…
2024-11-14 02:06:42 Economic burden of #LongCovid in the UK estimated to be >
2024-11-13 22:47:42 In other GLP-1 new publications today —Country-wide Sweden reduced hospitalizations for alcohol or substance abuse with these drugs https://t.co/qUh5HG0NHN @JAMAPsych —Concerns about discontinuation https://t.co/kknT7E5cFl @JAMA_current https://t.co/QOcoAtG6c6
2024-11-13 22:33:26 Case in point: successful treatment vs a fatal childhood brain tumor #DMG #DIPG @Nature today @michelle_monje and colleagues @StanfordMed @StanfordCancer https://t.co/fwi5l97rCM
2024-11-13 22:00:16 New @NEJM A whopping (~90%) reduction of progression to Type 2 diabetes with tirzepatide (GLP-1 drug, dual receptor) vs placebo in a randomized trial of >
2024-11-11 22:23:10 On the increase in alcohol intake that occurred with Covid in the United States https://t.co/UXqvIktjuR @AnnalsofIM @AyyalaDivya @AdamMLeventhal https://t.co/njg0VurZkT
2024-11-11 20:29:07 @ScottyWitte @theNCI @NCIHTAN @CharlesSwanton @cbailey_58 @oriol_pich @mischellab @MariamJHanjani @Nature Have been for more than a year https://t.co/4JZ7Lg24nd
2024-11-11 20:24:28 @theNCI @NCIHTAN Or the rogue, pernicious extrachromosomal DNA (ecDNA) that revs up tumor growth and block immune response, carrying a poor prognosis for patients https://t.co/6lmgNKHbB7 @CharlesSwanton @cbailey_58 @oriol_pich @mischellab @MariamJHanjani @Nature https://t.co/FbBZddomoJ
2024-11-11 19:25:17 RT @CarryLions: @EricTopol @NatureAging @BartolomucciLab Couldn’t have put it better myself! Thank you for the spotlight on our work!
2024-11-11 16:28:35 An experiment that couldn't be done in people (but might be applicable). Mice subjected to chronic social stress had accumulation of senescent cells in their brain, accelerating the brain aging process @NatureAging https://t.co/UfeoPQ1U74 @BartolomucciLab @CarryLions
2024-11-09 20:10:04 RT @_CatintheHat: @diannahaze This is a superb article from @zalaly &
2024-11-09 20:04:47 I'm not giving up. Not letting any political agendas interfere with dissemination of life science and medical stuff via this channel and others. The latter includes Substack, Threads, LinkedIn, Bluesky, and Mastodon.
2024-11-07 19:41:37 Importance of the liver's vagus nerve for regulating circadian rhythm of food intake https://t.co/FfLowxdUgA @LaurenNWoodie https://t.co/d4vxRIlOmx @noeliamartsanc @davidra17581122 @ScienceMagazine @ScienceVisuals liver-brain axis for potential anti-obesity target https://t.co/Ov3Sy28UFj
2024-11-07 19:24:52 The Covid pandemic suppressed Flu. A new @ScienceMagazine study investigated why https://t.co/e650W6MVcs —nonpharmacologic intervention (masking, physical distancing) —reduced international travel —change in virus lineage dwell times https://t.co/PuUxQHqJw9
2024-11-07 17:32:49 How can autoantibodies directed against the same target be both harmful or protective? Very goodby @EliverGhosn, senior author of this unanticipated finding https://t.co/Xcm91zwIq0
2024-11-05 01:10:34 I just passed my 15-year anniversary on this platform. It has substantially changed over the years, especially during the pandemic and X. Nonetheless, it still provides the most extensive reach to share interesting and important biomedical advances. That’s why I plan to stay… https://t.co/R4AVoCPClo
2024-11-04 18:43:24 RT @EricTopol: Meet Dr. Rachael Bedard, a physician who cares for and stands up for the people who can't stand up for themselves In the new…
2024-11-04 18:26:07 RT @JeremyFarrar: @EricTopol @NatMetabolism @CraigEdBrown @MyUVic Thanks for sharing @EricTopol - Worth linking role of IL-10 in infectious…
2024-11-04 17:05:33 RT @labs_mann: Check out the excellent ’Dawn of spatial medicine’ blog of Eric Topol where he describes our TEN DVP paper from last week.
2024-11-02 17:52:09 Forget about the election this weekend. There's so much exciting stuff going on in life science and medicine right now, not to miss. Free to subscribe, no ads. Ground Truths. https://t.co/YllXW9IAcMhttps://t.co/TiuB1eFel8
2024-11-02 15:56:36 @AshleySchapitl Thanks for noting!
2024-11-02 15:44:16 @JaneAFlegal Agree! She's a real gem. Thanks for weighing in.
2024-11-01 00:56:18 The impact of climate change on health @TheLancet https://t.co/j2bTSyLWjJ a 50-page report Reduced healthy life expectancy at birth, increased vulnerability to infections and pandemics, sleep loss, job loss, increased indoor PM 2.5, food insecurity, and a lot more. Open-access.… https://t.co/97w0mx0e1Thttps://t.co/ZfipEmBNDE
2024-10-31 16:00:43 Before this exciting discovery, a concise summary of what we knew about the brain-immune system protection or "guardians of the mind" https://t.co/7tKslqpbfD @stemcellreports https://t.co/fDmOv8hDzS
2024-10-31 15:52:33 Of ~5 million people with diabetes in a United States cohort, only 4.2% underwent screening for retinopathy over 5 years https://t.co/UcGBa3KClg @JAMAOphth Supposed to be done in 100% to prevent blindness
2024-10-31 15:19:12 A remarkable visionary perspective for the role of #AI agents to promote discovery in life science, laid out by @marinkazitnik and colleagues @CellCellPress https://t.co/xG6yBECZK6 @KempnerInst @HarvardDBMI @broadinstitute https://t.co/bKytAcduLB
2024-10-29 21:21:46 Across 7 countries, the incidence and symptom complex of #LongCovid, based on the new @WHO criteria (10 databases, >
2024-10-29 21:05:26 @BoWang87 Great work!! We need this
2024-10-29 19:46:53 The latest LLLM (large language of life) foundation model, with state-of-the art chronological age estimation, prediction of outcomes, and performance across different datasets and conditions https://t.co/QJGYC6Bj6g
2024-10-29 14:40:25 Identifying new cancer susceptibility and protective gene variants, new mechanisms, using gene-based burden tests https://t.co/9ecAIQrsVM @NatureGenet @erna_valdis @decodegenetics https://t.co/OfkmYvIFNh
2024-10-27 14:48:10 @labs_mann @NatureBiotech @MundAndreas @MPI_Biochem @Nature Link to my post about all of this https://t.co/3FxdGCexBz
2024-10-27 14:46:53 @labs_mann @NatureBiotech @MundAndreas @MPI_Biochem Here's the new @Nature paper, the first time spatial omics was used to save lives https://t.co/lUiEJL0lGIhttps://t.co/qHnC769NL6
2024-10-27 14:43:55 This breakthrough was an outgrowth of deep visual proteomics, pioneered by @labs_mann, with the main steps graphically outlined below https://t.co/Hwyahov61x @NatureBiotech @MundAndreas @MPI_Biochem https://t.co/diyRaaphB0
2024-10-25 14:32:03 Challenging medical dogma: After a stroke from atrial fibrillation, blood thinners should be started early (<
2024-10-25 14:29:07 Reassuring: decades after stem cell transplants, no indication of increase in cancer related gene mutations https://t.co/l0a7fUiPLD @ScienceTM https://t.co/aQJesDzEAd @Nature
2024-10-25 14:01:24 Here's the new CDC #SARSCoV2 genomic surveillance showing the XEC variant's continued rise, now accounting for about 1 in 5 cases in the US https://t.co/kv3jEFibgxhttps://t.co/vEAxdRnlu1
2024-10-25 00:19:22 RT @EricTopol: A substantial reduction of #Alzheimers disease associated with semaglutide (Ozempic) in >
2024-10-23 14:13:19 Systematic review of 51 studies on Covid transmission during airplane flights —sporadic clusters, proximity to cases —masks helpful for mitigation https://t.co/TmBnoib7Jo
2024-10-23 13:28:39 The increased risk of heart disease associated with exposure to arsenic in the water supply at or below the regulatory limit level https://t.co/1zzWUElteNhttps://t.co/iHzTALuxmo
2024-10-21 21:45:16 A systematic review of 44 randomized trials of #AI assisted colonoscopy shows significantly improved polyp detection rate https://t.co/cj47bRR8kD @AnnalsofIM https://t.co/vgFefG1Iqj
2024-10-21 14:56:54 A discovery of a bacterial derived enzyme that could change the face of many autoimmune diseases that involve IgG auto-antibodies https://t.co/MaYy39C8iG @CellCellPress @EmoryUniversity @RockefellerUniv https://t.co/AtabPUwrtI
2024-10-20 23:48:24 RT @AkassoglouLab: It was such a great pleasure discussing our research with @EricTopol in the Ground Truths podcast! Thank you for highlig…
2024-10-19 17:00:50 An elegant @Nature study by @AkassoglouLab has illuminated our understanding of the role of fibrin (component of blood clots), #SARSCoV2, and brain inflammation in Covid and #LongCovid. This discovery and more in the new Ground Truths podcast, with transcript, key figures (such… https://t.co/lrm8HPvAoVhttps://t.co/tSHtoIt8u0
2024-10-18 15:48:49 Mapping cancer resistance functional gene variants by #CRISPR genome editing, enabling effective alternative treatments https://t.co/A3h3h7aCr8 @NatureGenet @MatthewACoelho @Garnettlab @sangerinstitute https://t.co/s01FQaVqDX
2024-10-18 15:29:20 The GLP-1 drugs we've got now are just the beginning. The gut nutrient cell sensors ( a cellular instead of a peptide hormone target) have considerable potential. Brief thread by @HansClevers on their new @ScienceMagazine paper https://t.co/fIgAMBWvrJ
2024-10-18 14:37:22 Why intermittent consumption of a high-fat diet may be bad for you
2024-10-18 14:04:26 RT @NightShiftMD: Bottom line: current vaccines should work.
2024-10-17 22:30:31 @Dogma702 Much appreciated. Will stay on it until we have 'em here
2024-10-17 22:29:58 There's a pressing need to improve the efficiency of accurately detecting antimicrobial resistance. How about generative #AI? https://t.co/YDG5rFhXtF A problem of over-flagging, for now https://t.co/gthjEWO17F
2024-10-17 18:16:58 RT @EricTopol: The influence of diet on our immune system function is getting increasingly recognized, a feature today @Nature https://t.…
2024-10-15 21:53:16 Does an AI/ML model provide more accurate warning of clinical deterioration than older models (logistic regression or point-based) among >
2024-10-15 19:42:10 How important circadian rhythm is for promoting our health: a study of ~89,000 @UK_biobank participants with 13 million hours of light sensors https://t.co/yf84XtD0YL @PNASNews @circadian247 "Minimizing night light, maximizing day light, and keeping regular light–dark patterns… https://t.co/x26nl3AXjzhttps://t.co/yFuDvEh5Gy
2024-10-15 18:32:51 Loosening restrictive access to GLP-1 drugs could save over 40,000 American lives per year https://t.co/azmqiA6rxm @PNASNews @abhiganit @Alison_Galvan @YaleSPH https://t.co/eQK5rZDDmi
2024-10-15 18:24:36 The potential for cell therapies is exploding, well beyond cancer and autoimmune diseases. Here's a new review for neurologic disorders @NatureMedicine https://t.co/G63YuH0FnL @CliveSvendsen @CedarsSinai https://t.co/kmaGLuLsSx
2024-10-15 17:27:51 On the first 1,000 #AI medical algorithms ("devices") authorized by @US_FDA https://t.co/CzbPqgHyvu @haiderwarraich @DrCaliff_FDA @JAMA_current https://t.co/oIUGyuIr4p
2024-10-13 23:17:27 RT @EricTopol: This week in key Covid publications and preprints: —Increased risk of major adverse cardiovascular events 3-years out, irres…
2024-10-13 17:01:48 RT @UrnovFyodor: I have learned a lot from @EricTopol and from @pdhsu - I strongly suspect you will as well and thus recommend this convers…
2024-10-13 16:49:48 @mybadauditions @simonschuster Right! If only the publishing industry could move into the 21st century…….
2024-10-11 22:50:27 @JPWeiland If only it would stay that way.........but it won't!
2024-10-11 19:46:35 Why is the XEC variant on the move to be next up, when there's little change in its spike protein compared with KP.3.1.1? Its growth advantage appears to be a new path—due to the change in the nucleocapsid protein (case for this cracked by @LongDesertTrain), which is the 1st time… https://t.co/8Ud5AzUiWmhttps://t.co/G3GkLDlJD8
2024-10-11 19:01:49 Is loneliness a risk factor for #Alzheimer's disease and cognitive impairment? —Yes, association from a meta-analysis of >
2024-10-11 18:46:18 RT @VirusesImmunity: Much-needed data on the genetics of #longCOVID in a new preprint by @23andMeResearch - GWAS of #LongCOVID identified…
2024-10-08 23:12:52 @PeterHotez Much appreciated, Peter. You're the best!
2024-10-08 23:09:30 At the @NobelPrize press conference today, @geoffreyhinton's predictions for #AI's future impact https://t.co/PAr85BO6eJ
2024-10-08 21:47:50 @wendysueswanson @simonschuster Many thanks, Wendy Sue!
2024-10-08 17:23:12 A very thoughtful review and analysis of the interactions between the brain, the aging process, and energy cost/ conservation, by @MitoPsychoBio and colleagues @NatureAging https://t.co/oHbMpwO5ZLhttps://t.co/vCULSaH8Hz
2024-10-08 16:51:41 @LundinAdvocates @dysclinic Absolutely! She's a gem
2024-10-02 20:12:55 Novel method of LLM #AI for mental health diagnosis: Inputs of a person's speech patterns including variations in rhythm, pitch variability and voice quality that are typically imperceptible to human ears. Gift link https://t.co/SlTy3plM73https://t.co/oj0ODYe0Wjhttps://t.co/JsKpTZw4TP
2024-10-02 17:14:35 The association of road traffic noise and risk of atrial fibrillation, a multi-national prospective assessment https://t.co/PjbJ68A5b0
2024-10-02 16:26:56 Mapping the brain of the fruit fly, smaller than the head of a pin, with 140,000 neurons, 50 million synapses. that took 5 years. It wouldn't have been accomplished without citizen scientists and volunteers! @Nature https://t.co/qhvpKtjqJ7https://t.co/HDYHk2lld6
2024-09-30 21:29:28 In a randomized trial of time-restricted eating for people with metabolic syndrome for 3 months vs standard-of-care, the HbA1c improved 0.10%. Yes, that's zero point 1 per cent. https://t.co/RriB4fZati @AnnalsofIM https://t.co/loV0uyQJ4T
2024-09-30 18:45:15 Importance of carotid artery atherosclerosis progression by ultrasound (carotid plaque burden, cPB) for prediction of all-cause mortality in a prospective study of 5,700 participants without symptoms https://t.co/hf3XIRTCxg cPB was more informative for risk than coronary artery… https://t.co/ljBvtnKb4Vhttps://t.co/0MQfnJ9A0C
2024-09-30 17:48:06 A prospective study of the impact of air pollution in ~175,000 participants newly diagnosed with T2 diabetes with over 8 years follow-up https://t.co/8MlQi0Z1Bz PM 2.5 exposure associated with increased all-cause mortality and multiple adverse outcomes https://t.co/aBBs0Tmjnd
2024-09-30 15:53:10 RT @EricTopol: My piece @ScienceMagazine today What happens when you can assay over 10,000 proteins in the blood, in tens of thousands of…
2024-09-29 18:48:41 The same group @RockefellerUniv, led by @casanova_lab, published this important paper @ScienceMagazine 4 years ago, on the life-threatening implications of pre-existing Type 1 interferon auto-antibodies https://t.co/upmsYwWQyQ Exemplifies the false dichotomy of "immunocompetent"… https://t.co/JQMUIFG62nhttps://t.co/i7WyU5VMjN
2024-09-29 17:59:33 @EckerleIsabella Along those lines, the authors of this nasal vaccine paper recently published https://t.co/a0b3suXunM showing ~100-fold increase of ability to neutralize various Omicron variants by nasal secretory IgA vs serum IgG or IgA antibodies, again highlighting the importance of mucosal… https://t.co/9bIvZbIbmjhttps://t.co/yFeglJYdJk
2024-09-29 14:57:19 RT @EckerleIsabella: Great reminder that mucosal immunity rocks! In my view, such vaccines will be the key for the next emerging respirator…
2024-09-25 22:32:43 RT @EricTopol: Two doses of a Covid nasal vaccine spray led to >
2024-09-25 17:53:40 Despite lack of data or evidence, there's no shortage of people advocating taking rapamycin, who take it themselves. A list from a year ago https://t.co/zfp19sg73f
2024-09-25 17:33:26 "At least 86.2% participants who completed 2 [nasal vaccine] doses maintained uninfected status, likely without even asymptomatic infection, for at least 3 months."
2024-09-25 15:17:54 The GLP-1 drugs are the most important drug class breakthrough in medical history. We're still learning how they have such broad impact, especially about their anti-inflammatory effects, systemically and in the brain https://t.co/8HagDdLsj7 A new feature @Nature, by @marilenharo https://t.co/ocofHjs28ehttps://t.co/WWoZyAtUYV
2024-09-25 15:07:40 More unanticipated capabilities of machine (digital) eyes....... The 12-lead ECG prediction of heart blood flow https://t.co/nonxbYY1UY @CellRepMed @fares_alahdab @almallahmo @JiaWu_PhD https://t.co/KZRWDTBy1H
2024-09-24 01:54:56 @loafnw @random_walker @sayashk @Princeton Much appreciated!
2024-09-24 00:51:00 This book —AI Snake Oil—is being published tomorrow, by @random_walker and @sayashk of @Princeton. We discussed it on the new Ground Truths podcast. With transcript and external links to relevant papers. Link in my profile https://t.co/vw4SDQ7fbO
2024-09-23 19:57:05 @casanova_lab Important advance. Congrats!
2024-09-23 19:31:31 About 10% of people who develop severe Covid have autoantibodies to Type 1 interferon, which doesn't get diagnosed. Now there's a simple assay. It's also relevant for other life-threatening viral illnesses, and these Abs exist in ~100 million people worldwide.… https://t.co/zn8qPOo7o0https://t.co/MDyGyI363A
2024-09-23 15:18:52 One-third of former professional football players (N~2,000) perceived they are affected by chronic traumatic encephalopathy (CTE) https://t.co/teBC8mF0kL @JAMANeuro
2024-09-21 14:34:59 We're entrenched in a culture of [blood] cultures for diagnosis of sepsis https://t.co/IAkPYE3keX @TheLancet @UKAMREnvoy @mtosterholm @RickABright Yup. I wrote about this a couple of years ago at Ground Truths and nothing has changed (link in profile) https://t.co/rx6AQ04d5r
2024-09-19 02:38:27 @SolidEvidence @LongDesertTrain You both may well be right. Watching this with keen interest.
2024-09-18 22:48:49 The increasing global burden of stroke, despite~80% considered preventable, with air pollution now on par with smoking as a risk factor https://t.co/2iBGuhD3um @TheLancetNeuro https://t.co/sQV6t4Tj1G
2024-09-17 00:09:09 Bacterial antimicrobial resistance, which is steadily increasing, looms as a major threat. This new @IHME_UW report @TheLancet comprehensively reviews the past 3 decades and forecasts out to 2050. https://t.co/7fI3VOgY7Q open-access Much more needs to be done to avert tens of… https://t.co/QuVsfiqMBMhttps://t.co/Ex0pYtKaJt
2024-09-16 20:52:31 Social determinants of health (SDoH) greatly affect risk of disease and outcomes, but they are usually not (or very incompletely) assessed in patients. Now LLM #AI is showing potential to help do that from clinical text https://t.co/CI7DHPAaDr @PNASNews https://t.co/ra6lhghhVH
2024-09-16 19:36:57 New immunology insights for #LongCovid Key #SARSCoV2-specific T cell receptor signatures maintained to 2 years compared with unaffected control participants @PNASNews @louiserowntree @TheDohertyInst @kedzierskalab @ProfPCDoherty https://t.co/4dDoe4Ftx4https://t.co/2Hr6O7qTUU
2024-09-15 00:41:23 @iamzeeeggman They are all good. Novavax has less acute side effects.
2024-09-15 00:10:40 At this juncture, the XEC variant appears to be the most likely one to get legs next. Its current status nicely tracked by @Mike_Honey_ 's thread https://t.co/4AnLa3MXfz
2024-09-14 15:25:49 Many countries provide guidelines for the public to avoid ultra-processed foods, but not the US. Perhaps, finally, a start here
2024-09-12 23:25:04 High lipoprotein(a) [(Lp(a)] is a genetically determined, important risk factor for cardiovascular disease that should be (but isn't) routinely measured (at least once). There are 5 drugs that look highly effective for markedly lowering levels in clinical trials. This new… https://t.co/wfFVDA4yfMhttps://t.co/h1DViytOcF
2024-09-12 23:07:19 Digital medical research exemplifies techquity, expanding the reach to people who can not or will not access site-based, conventional clinical efforts Our new @TheLancet essay https://t.co/gkPHFaON5u @julialmv, Vik Kheterpal @ScrippsRTI @scrippsresearch @careevolution https://t.co/srgFLUMDJ3
2024-09-12 22:42:21 More perspective and critique here, @Nature @maxdkozlov https://t.co/c7ubImSzPS —impact on brain aging most prominent of any organ —clearcut suppression of chronic inflammation —but based on only 12 monkeys assigned to treatment —as my previous post, absolutely requires… https://t.co/99SBYEAi3C
2024-09-12 16:46:27 —The age of the monkeys studied was between 13-16 years, which is equivalent to human age 40-50 years —The dose used was 20 mg/kg, which is on the high end of human dosing —It's an interesting report but there are conflicting data for metformin's effect
2024-09-11 13:43:26 An unsolved mystery, summary of work in progress to understand basis of propensity for metabolic syndrome and cardiovascular disease. Feature @Nature https://t.co/QsmYDhbe4V by @AnilOza16 https://t.co/whMQp2oPKn
2024-09-11 13:32:12 The impact of stress on sperm function, serially assessed in healthy men, noting a delay of 2-3 months for key changes to manifest https://t.co/fPk3S6oBse @NatureComms @neuronickole @TheBaleLab https://t.co/YnkXfzQVla
2024-09-11 12:51:46 THE ROAD TO WISDOM is a remarkably thoughtful and inspirational book out this week by Francis Collins. Our conversation about it and other related, important matters in the new Ground Truths podcast. (Link in profile d/t X-suppression) https://t.co/ZbTL05MMlYhttps://t.co/dXAowtNWQ6
2024-08-23 15:53:09 Epigenetic aging clocks have become a commonly used metric in medical research and are being marketed to consumers. The new Ground Truths with @prof_horvath, who discovered these clocks a decade ago, provides a frank appraisal of their progress, limitations, and promise. With… https://t.co/ZeKHedfrI8https://t.co/aOPGXOmfCA
2024-08-23 14:43:00 In the era of large language models: "The extensive efforts previously required to standardize and make coding systems and ontologies interoperable for traditional computing are no longer necessary." https://t.co/lUZsgF77kz by @jnkath @DanielTruhn @Dykex6 @IsabellaWies… https://t.co/1619XhjLglhttps://t.co/dshSJOodVb
2024-08-19 21:37:49 Nice explainer for these 5 patterns of brain aging and how they can help predict risk @Nature https://t.co/Dg21bLa3xK
2024-08-19 20:52:27 This is a new finding and adds to the Ground Truths conversation with @euanashley link in profile https://t.co/wBCjavALPh
2024-08-19 19:35:32 A correlation between increased cardiorespiratory fitness (V02 max) and protection from brain aging (reflected by less demyelination) https://t.co/s5Rjvs3IEg @PNASNews @MusBouhrara https://t.co/oaw87P8a4X
2024-08-19 18:00:37 Latest wastewater data on the current wave Shows signs of peaking in all regions except Northeast https://t.co/KlD5tDMHOb
2024-08-19 15:05:43 To help address the antimicrobial resistance crisis, there are hundreds of very promising antibiotic candidates found hiding in our microbiome https://t.co/WhBLyI63Vw @CellCellPress @delafuenteupenn https://t.co/Q9RgbncnXQ
2024-08-17 18:34:46 @LongDesertTrain @SystemsVirology @StuartTurville Thanks Ryan. Would be good to solve this mystery
2024-08-17 15:42:57 The number of different ways cancer can hijack our cells is striking. Add this mechanism to the list: recruiting macrophages that suppress our immune response https://t.co/oT1hJAczQ7 @NatureCancer
2024-08-17 00:42:45 Here is the main text of the report in case you had any difficulty accessing it https://t.co/QtM2Hn3WbI
2024-08-17 00:25:27 Just published is the KP.3.1.1 characterization by @SystemsVirology, which helps explain why this has become the dominant variant here and throughout many other countries—higher infectivity and more immune evasion than other variants, w/ its S31 deletion playing a key role… https://t.co/wvQDpak8nZhttps://t.co/vOXO6TL7o0https://t.co/KXVMWNkmHY
2024-08-15 23:28:44 Tirzepatide (Mounjaro) achieves more weight loss than Semaglutide (Wegovy), but how do clinical outcomes compared in the real world? https://t.co/Ffu5b4Zl19 Major differences in less Type 2 diabetes, all-cause mortality and cardiovascualar events https://t.co/aNcQJoXnO7
2024-08-15 18:17:33 How sleep resets the brain for new memories Discovery of new type of hippocampus neuron firing called BARRS (barrage of action potentials) that go silent during deep sleep https://t.co/0oKAvhVtefhttps://t.co/2zDCEAsobB @ScienceMagazine https://t.co/3ZCbNbdGvr
2024-08-15 18:05:45 Just out @ScienceMagazine New insights from #SARSCoV2 structural biology for pan-betacoronavirus antibodies (which could also be factored into developing universal vaccines) https://t.co/SkopcnxvpKhttps://t.co/CkUDArIfOD
2024-08-15 14:45:48 RT @EricTopol: My conversation with @pnatarajanmd on preventing cardiovascular disease is the new Ground Truths podcast —how low to go for…
2024-08-14 01:40:49 @bluestarpr @YouTube Thanks. We’re trying to get @23andMe to make this work again. Sorry for the difficulty
2024-08-14 01:24:25 RT @pnatarajanmd: Great conversation with @EricTopol on the Ground Truths podcast! We covered a lot! @MGHHeartHealth @MGH_RI @broadinstitut…
2024-08-13 23:05:47 Great advice on ? apoB (a snippet) Full video interview @YouTube (link in post) https://t.co/YFnpXdQ7qW
2024-08-13 22:55:50 My conversation with @pnatarajanmd on preventing cardiovascular disease is the new Ground Truths podcast —how low to go for LDL cholesterol? — apoB, Lp(a), polygenic risk score, CHIP, role of inflammation —new RNA drugs [sorry, link is in my profile due to X-suppression] https://t.co/quKclLig8ehttps://t.co/gDKoSKS3NL
2024-08-13 14:45:25 Creative approaches, all of which are desperately needed, to address the antimicrobial resistance crisis https://t.co/EafBBNyecc @Nature including #AI, harnessing natural products
2024-08-11 14:08:53 "We seem to have memory-holed not just the suffering of Covid-19 but also the initial burst of inspiring if imperfect solidarity it produced"—@dwallacewells https://t.co/oLkFlBLwJbhttps://t.co/xCGxQXZCrH
2024-08-09 23:17:22 Explainer for the groundbreaking proteomic clock paper @Nature https://t.co/krK3exzit3
2024-08-09 14:28:59 RT @PamBelluck: About 400 million people worldwide have had long Covid, presenting a global economic cost of $1 trillion a year, a new repo…
2024-08-09 12:27:57 RT @zalaly: Our review "Long COVID science, research and policy" is out in @NatureMedicine By @zalaly @ahandvanish @LisaAMcCorkell @letic…
2024-08-08 21:14:11 @austinargen @NatureMedicine Easy when it's so exceptional and groundbreaking! I meant what I wrote as a "landmark" contribution Thanks
2024-08-04 19:58:08 RT @EricTopol: Much of dementia—perhaps half—could be prevented or substantially delayed with attention to 14 modifiable risk factors @The…
2024-08-04 18:26:28 RT @EdBelongia: Nice COVID19 summary by @EricTopol. Some key points: Summer wave of KP.3 variant w/ more severe cases. Consider old b…
2024-08-04 16:27:35 Summary Figure from the new review and my previous Ground Truths post on this topic https://t.co/KtGZ7QgDyM
2024-08-04 16:27:34 We keep ignoring CHIP (clonal hematopoiesis of indeterminate potential= mutations in our blood stem cells) even though it is no longer "indeterminate." A key marker for risk of cardiovascular events and blood cancers. It should be routinely assayed in older adults.… https://t.co/gBGMwojZcFhttps://t.co/86iZ6m2hvR
2024-08-04 14:58:59 Explainer for current US Covid wave and action plan With links to work by @profshanecrotty @SystemsVirology @JPWeiland @VirusesImmunity @trishgreenhalgh @zalaly @BernieSanders @WUSTLmed #LongCovid [Sorry, link is in my profile because it is otherwise X-suppressed] https://t.co/FZA86ZKrUh
2024-07-24 22:52:50 Which simply adds more to the state-of-the-science review by @trishgreenhalgh and colleagues. https://t.co/b8JC8yNanc
2024-07-24 22:42:14 A randomized trial in over 4,500 participants for surgical masks [2 weeks, public places] vs controls [no masks] found a 30% reduction (3/100 absolute) of respiratory symptoms consistent w/ infections https://t.co/GUGNFvNFXf @Runar_Solberg @bmj_latest https://t.co/IRMAEGWBRQ
2024-07-24 19:09:31 Learning from single-cell RNA-seq of 1.3 million brain cells from 16 individuals with #Alzheimers disease and 32 controls. Potential protective of Reelin and choline intake/supplementation https://t.co/kLVAqj2qnz @manoliskellis @MathysHansruedi @carles_boix @DrLiHueiTsai and… https://t.co/eM1zP6BtUx
2024-07-21 15:13:23 Meanwhile, not enough is being done to get nasal vaccines (to prevent infections) and universal shots (vs all variants) ready, which would get us out of this vicious cycle of waning immunity, new variants, and reliance on shots which don't achieve mucosal immunity 5/5
2024-07-21 15:13:22 But the FDA has tried to force fit Covid into an annual shot like flu, even though all data tells us it doesn't follow an annual pattern. Even the CDC acknowledges this now https://t.co/Jp6c06ahik 3/5
2024-07-21 15:13:21 We've known about KP.3's marked growth advantage since April and could have made the call then to make the new booster. That would have been aligned well with the current wave (available in July) https://t.co/iPNXFDardi 2/5 https://t.co/09Bht8ifQk
2024-07-21 15:13:20 The new boosters (vs. KP.2) should be available the first week of September. It takes ~90 days make them from the FDA decision on June. https://t.co/vWxxNw7FdF But it didn't have to be that way.......1/5
2024-07-19 19:48:09 RT @JPWeiland: July 19th update: Another substantial increase this week (+26%). Wastewater signal now higher than last summer's peak, and…
2024-07-19 17:25:50 Just in case you thought the virus wasn't still evolving. Mapped by @dfocosi https://t.co/mHeUaaYaW3
2024-07-19 16:17:31 RT @EricTopol: The GLP-1 drugs have favorable actions well beyond weight loss. How? A succinct @ScienceMagazine review by @DanielJDrucker,…
2024-07-19 15:43:55 The relationship between sleep duration and some chronic conditions in ~7,000 @AllofUsResearch participants @NatureMedicine https://t.co/7xfmnraKnVhttps://t.co/i2huEUj40I
2024-07-11 22:58:26 The Long Haul, a book on #LongCovid by @r_prior, reviewed by @mendenhall_em @TheLancet Appropriately spotlights the extraordinary patient activism "It's really possible they changed the history of medicine"—@zalaly https://t.co/ZhV0rkssWmhttps://t.co/PRs8kZEpx0
2024-07-11 18:38:28 While progress has been made with genomics and wastewater surveillance, digital is the big miss. My colleague @JayPandit put together a review paper on this topic @NatureBiotech https://t.co/NswHMmwjPl @ScrippsRTI @scrippsresearch @GiorgioQuer https://t.co/bGhFlpBTLH
2024-07-11 18:14:19 One of the big missed opportunities in the pandemic was more use of digital tracking. A new @ScienceMagazine paper by @ChristoPhraser @LucaFerrettiEvo and colleagues shows its rich, real-time transmission assessment, value beyond contact tracing https://t.co/5huwzB9CPDhttps://t.co/a5yGA3xex7
2024-07-11 16:18:01 Discovery of a molecular switch basis for lupus (SLE) using #CRISPR screens to unravel the CXCL-13 T cell circuitry @Nature https://t.co/TrRqadQ8ri @CalvinYLaw_ @Deepakarao @jaehyukchoimd @vwacle @NorthwesternMed https://t.co/VMMWbs8DZl
2024-07-06 17:11:14 RT @BJJscientist: “Exercise could be the most powerful medical intervention ever discovered." In @EricTopol's Ground Truths, learn why no…
2024-07-06 13:27:03 Does “one minute of exercise buy you five minutes of extra life”? My conversation with @euanashley on exercise In the new Ground Truths podcast (link in my profile) with transcript https://t.co/p3iINi6DWe
2024-07-06 13:17:47 RT @19joho: Many doctors who misinformed the public from day 1, like @ScottAtlas_IT, claim they were right. Yet, they refuse to accuratel…
2024-07-05 21:02:10 @ReiterLab Thanks. Missed that typo, fixed. Waist-to-height ratio (not weight)
2024-07-05 21:00:37 A group of 29 experts in Europe came to consensus on many aspects of #obesity diagnosis and management —a chronic, progressive disease —focus on abdominal adiposity —use waist-height ratio (>
2024-07-04 20:58:02 @CarlosdelRio7 @ylecun @ashishkjha @Ilibagiza @CarnegieCorp Absolutely! You’re in this group, Carlos
2024-07-04 18:16:44 A major medical milestone late last year was the first #CRISPR genome editing approval (Casgevy) vs sickle cell disease. But it's very complicated and expensive. How about an epigenetic modifier pill with the same target, as seen here @ScienceMagazine? https://t.co/IXhJM8zWfp… https://t.co/hmLZYsTNbjhttps://t.co/RpS8BVORZr
2024-07-04 18:03:22 The first tumor infiltrating lymphocytes (TILs) were FDA approved to treat refractory cancer (melanoma) this year. In the new issue @ScienceMagazine a rundown and perspective from the pioneer who worked on developing this living drug for >
2024-07-04 15:51:16 RT @EricTopol: Up to 2 years after Covid, persistent virus and T cell activation in multiple tissues, especially high in gut #LongCovid htt…
2023-05-22 15:28:45 Seeing pain the brain "The development of personalized pain biomarkers will be central to accurate diagnosis, tracking prognosis and for future therapeutic drug and device development." @NatureNeuro @PrasadShirvalka @NeurosurgUCSF https://t.co/l2RTmjRjhYhttps://t.co/rSzqvKvsF8
2023-05-22 15:26:43 @NatureBiotech Continuous wearable ultrasound using #AI to auto-capture body deep tissue imaging and physiology during mobility for up to 12 hours https://t.co/GVZwrLTEkr @JackLin62608901 @XugroupUCSD @JWangnano @UCSDJacobs
2023-05-22 15:09:19 "#SARSCoV2 was detected in aerosol samples up to 52 days after the initial infection." @NatureAging from aerosol monitoring of 3 Belgian nursing home outbreaks https://t.co/Y8xcfk7a1P #COVIDisAirborne @ElsKeyaerts @johanvawe and colleagues
2023-05-22 13:07:16 A biomarker has been validated as an independent and significant risk factor for heart disease and cancer, but isn't being used clinically. Why? https://t.co/notqyijOMHhttps://t.co/EPtoEwNbSG
2023-05-20 17:49:11 This is part of the Hospital-at-Home movement, reviewed here https://t.co/W95yJBsFGp
2023-05-20 15:51:22 #MONITORHF trial @HFA_ESC #HeartFailure2023 Presented today by Jasper Brugts, @rudolf_deboer and colleagues https://t.co/xPzNGd5ku3
2023-05-20 15:42:28 @TheLancet A randomized trial in patients with heart failure shows superiority of remote monitoring for prevention of hospitalizations and marked improvement in quality of life metrics compared with standard care https://t.co/HKtWu8VMid @escardio @rudolf_deboe https://t.co/LNGegBNC9F
2023-04-15 00:10:53 RT @pnatarajanmd: Why do hibernating bears, despite prolonged immobility, not get venous thromboembolism? In a new study, scientists prior…
2023-04-15 00:09:43 @DocJeffD That’s a key point that many people miss. Thanks
2023-04-14 22:46:33 RT @JPWeiland: According to wastewater data from https://t.co/BDwnbGcDaH, US infections are the lowest they've been in over a year. Out of…
2023-04-14 15:11:42 This week there have been 2 important reports that reinforce the bivalent BA.5 booster did better than expected 1. Protection vs BQ.1.1 and XBB.1.5 https://t.co/tBIutN6SVP 2. High effectiveness vs severe Covid in large cohort age 65+ https://t.co/tt54BE3WzIhttps://t.co/Qfhqrdqrw2
2023-04-14 14:59:09 The XBB.1.16 variant, with a decided growth advantage as seen in India, is starting its overtake to become the dominant one in the United States https://t.co/jjl2AnOYb5 Clinical implications are unclear, but likely not a significant wave here. Still reason to be cautious. https://t.co/LFu2TA3J3i
2023-04-13 22:42:52 "This study is one of the first to evaluate real-world effectiveness of the bivalent mRNA vaccine booster to reduce hospitalization or death due to Covid-19." 68% reduction of death https://t.co/2RjM4XpUWY
2023-04-13 22:39:25 A 72% reduction of Covid hospitalizations with the bivalent (BA.5) booster vs not boosted in people age 65+ https://t.co/5Bw8YvZwvm @TheLancetInfDis @ClalitHealth @ClalitResearch @ArbelRonen and colleagues https://t.co/9eo6ES4up3
2023-04-13 17:09:01 It's not (usually) cancer that kills
2023-04-13 13:57:44 A T-cell directed vaccine against Covid, with non-spike, conserved antigens (e.g. nucleocapsid, ORF1ab), effective in experimental models for preventing disease, has gone into clinical trials https://t.co/Iahj9pTCzIhttps://t.co/JbQYGGjd8c @CellCellPress https://t.co/j1wJGVHLNT
2023-04-13 13:36:36 Beyond autoimmunity as a mechanism for #LongCovid, the heightened risk of autoimmune diseases "Compelling and reliable evidence that #SARSCoV2 infection is linked to a substantially increased risk of developing diverse new-onset autoimmune diseases..." https://t.co/QJx7nBcvGehttps://t.co/D1qPPNONbL
2023-04-13 00:50:54 If you’re interested in how #AI will reshape healthcare in the large language model era https://t.co/49Z35U2hED
2023-04-12 23:07:50 A significant advance for #Parkinsons disease: the biomarker α-synuclein is an accurate classifier, detects very early (prodromal), and a target for Rx as determined in a large cohort with controls https://t.co/NEQUzefu0n @TheLancetNeuro https://t.co/v7IBfpkgSL
2023-04-12 21:24:06 A tour de force work in clinical genomics: >
2023-04-12 21:01:00 The bivalent (BA.5) booster protection from Covid hospitalizations and deaths exceeded expectations vs the BQ.1.1 and XBB.1.5 variants https://t.co/0zi9RPBXC0 But VE waning seen
2023-04-12 18:04:48 National Public Radio (@NPR), a leading independent, trusted, non-profit news media organization in the United States that reaches millions of Americans every day, quits @Twitter https://t.co/QRZce75hLm
2023-04-12 17:47:53 RT @GaviSeth: Fascinating read by @EricTopol on the “major triumph” of new #RSV vaccines and why “this is the most exciting time in the his…
2023-04-12 17:45:06 @pnatarajanmd @Nature @AlexBickMDPhD @jaiswalmdphd Great body of work. Why isn't CHIP getting routinely or ever assessed in clinical practice?
2023-04-12 16:59:38 How to prevent Covid infections in multiple experimental models that were not prevented with shots. Sterilizing immunity by a nasal vaccine https://t.co/zfpVQozLJE And a potential 2-fer against flu! https://t.co/g3z3J67TE1
2023-04-12 15:14:59 I've summarized some of the key points in a new Ground Truths https://t.co/kL3oaMGUwH
2023-04-12 15:12:42 Our @Nature paper on Foundation models (aka Large Language, Generative #AI, such as #GPT4) for medicine was just published https://t.co/z6eB0l80vY @Michael_D_Moor @pranavrajpurkar @ZahraShakerii @jure @hmkyale
2023-04-11 22:23:11 RT @CrabbBrendan: I talk about this disconnect a bit in this thread. https://t.co/a4IvkWxGTg
2023-04-11 20:05:35 "We have isolated and characterized 2 human monoclonal antibodies which exhibited neutralizing activities against all #SARSCoV2 variants tested, including BQ.1. and XBB.1.5" https://t.co/jCiQumZgG0https://t.co/EpQAFemTuW
2023-04-11 17:36:05 As global confirmed Covid deaths reach a new low for the pandemic, excess mortality estimates are on the rise @OurWorldInData https://t.co/SJfbplurOg
2023-04-11 17:18:45 RT @chrischirp: Why or why aren't we investing in cleaner indoor air? It's a no brainer. It would be a no brainer even if covid had never h…
2023-04-11 17:03:20 Important work, nicely summarized by @VirusesImmunity's thread (above) and the paper's concluding paragraph https://t.co/tNgYfMnEIB
2023-04-11 16:24:03 @KenGursky From the @washingtonpost article. I'm quite upbeat we'll have a nasal vaccine to help block infections and this program will get us there faster https://t.co/NNisfRUX8X
2023-04-11 14:13:58 RT @EricTopol: Should you get a multi-cancer early detection (MCED) blood test? A solid, balanced appraisal of the new "liquid biopsy" 18…
2023-04-11 12:53:46 Immune evasion of #SARSCoV2 is not only via blocking our interferons or neutralizing antibodies. As the virus evolved, suppressing the T cell response now demonstrated. https://t.co/TsZj1ovs4K
2023-04-11 12:46:40 Print version of the announcement in today's paper https://t.co/8wMqq4evM9
2023-04-11 00:39:10 @pknoepfler @AnnalsofIM @BobVolkPhD @glynelwyn Hi Paul, I wrote about it some months back (last section), not much has changed https://t.co/e7Fl0F8BDW Short term ?
2023-04-11 00:17:40 Should you get a multi-cancer early detection (MCED) blood test? A solid, balanced appraisal of the new "liquid biopsy" 18 tests that, in healthy people, can pick up microscopic cancer and w/ #AI determine site of origin https://t.co/pmfXfWLUi5 @AnnalsofIM @BobVolkPhD @glynelwyn https://t.co/zGPa0XTSkp
2023-04-10 21:34:34 I wrote about Project Next-Gen—thankfully the United States has gotten serious about new Covid vaccines and treatments. https://t.co/bCN1afrKt9
2023-04-10 20:25:25 This is big, folks. The @WhiteHouse is supporting next generation—nasal and variant-proof Covid vaccines —and therapies with a $5 billion program https://t.co/fMxCJAzIA5 by @ddiamond Thanks to the relentless efforts of @AshishKJha46 and @WHCOVIDResponse
2023-04-10 19:53:28 How to reduce airborne disease transmission during indoor gatherings Besides mask-wearing, "ventilation and break times are critical" in prevention. "Their impact would equal or exceed that of masking and moderate isolation of infected individuals." https://t.co/ePxZTNRZhNhttps://t.co/wxusx7vSD9
2023-04-10 17:41:16 RT @EricTopol: A double feature Ground Truths in the past 2 days —Automated 24/7 cuff-less blood pressure wristband sensor https://t.co/Ek9…
2023-04-10 15:12:30 A randomized trial of coaching for physicians (N=40
2023-04-09 19:19:46 Chromosomal instability (CIN) "remains one of the greatest unresolved genomic challenges in cancer treatment" and may become druggable .https://t.co/n4XMLBv14I @ScienceMagazine by @Samuel_Bakhoum https://t.co/lV9LfXqDtS
2023-04-09 18:25:54 @CNakas Good to know. Thanks!
2023-04-09 18:18:39 RT @siobhannyc: “This is the most exciting time in the history of vaccines.” Great edition of this very great newsletter!
2023-04-09 17:07:05 RT @sarikaphatak: Non-invasive, cuff-less, continuous blood pressure monitoring bracelet - a holy grail of sensor &
2023-04-09 16:54:48 @BillyWcostigan She didn't have Long Covid
2023-04-09 16:44:09 After a patient saw multiple physicians and neurologists over 6 months and was assigned a diagnosis of #LongCovid, a relative entered her symptoms into #ChatGPT with the correct output. Diagnosis was confirmed by antibody testing and therapy has been initiated. https://t.co/lFfp1zZmRT
2023-04-08 17:24:27 RT @Daltmann10: Posts Exaggerate Lab Findings About COVID-19’s Impact on Immune System https://t.co/SD3LKVmg2m via @factcheckdotorg
2023-04-08 00:00:58 RT @JPWeiland: I'm honored to have my work featured in @NYMag along with @EricTopol ! Yes, the US is in a decent lul, but it's imperative…
2023-04-07 21:18:49 So Twitter won't allow responses or retweets to a Substack post. "free speech" https://t.co/5Dnyao4trN
2023-04-07 21:00:48 Characterization of the growth advantage of XBB.1.16 compared with XBB, XBB.1.5, with its increased fitness that will likely account for it replacing the current variants https://t.co/5yC2vlnp1v by @SystemsVirology
2023-04-07 20:34:26 @DKThomp I just posted a new @Substackinc and @twitter won't allow responses or retweets! https://t.co/Ek9AtGmET0
2023-04-07 20:31:47 Independent replication of some reduction (~25-30%) of #LongCovid with Paxlovid treatment versus controls, among non-hospitalized, vaccinated people with acute Covid https://t.co/52pBWBYpBt @rushin311 @SarjuGanatraMD and colleagues @LaheyMedicine @LaheyHospital https://t.co/bmMuo3ZAds
2023-04-07 20:19:23 The new Ground Truths is about a continuous BP monitoring bracelet I've been testing https://t.co/Ek9AtGmET0
2023-04-07 15:11:23 Spike protein in the skull-meninges An important niche of the brain immune response as reviewed in this new @ScienceMagazine paper https://t.co/RQ7uxMWQrahttps://t.co/yfJwjUoiGt
2023-04-07 15:02:15 XBB subvariants are starting to crowd out XBB.1.5 in the US without notable change in clinical outcomes. XBB.1.16 is here and not shown by @CDCgov tally, likely the one to overtake in the weeks ahead https://t.co/jjl2AnOYb5https://t.co/hdxN6pb4Smhttps://t.co/YRSB3jepwW
2023-04-06 22:59:29 How Covid is transmitted in households, via a prospective study and dense longitudinal testing (through Alpha variant wave) https://t.co/H9U8YVvgJl @LancetMicrobe Hands and surfaces play a role https://t.co/xxNC1Natwb
2023-04-06 22:08:45 This also relates to the very interesting report of #SARSCoV2 spike protein found in the skull-meninges-brain axis today https://t.co/N2tVLKn37A
2023-04-06 22:07:04 Our understanding of the brain and immune system has radically changed . A new, 5 review @ScienceMagazine today by @castel_giulia @Tommaso_Croese and @WeizmannScience colleagues w/ @ScienceVisuals https://t.co/RQ7uxMWQrahttps://t.co/k97SYiurRP
2023-04-06 21:24:43 Julia, better than R and Python, for life science? https://t.co/oZNEd7mR9e @NatureMethods by @Roesch_E @theosysbio @jgreener64 @nassarhuda @ChrisRackauckas @adamlmaclean @JuliaHubInc https://t.co/i82bgpMAEN
2023-04-06 17:34:27 The potential and a mechanism for diet and probiotics to rev up immunotherapy vs cancer and improve clinical outcomes https://t.co/zvyKyaFDYr @CellCellPress @MeiselLab @MackJBender @AlexCMcPherson https://t.co/crLnjgJkPM
2023-04-06 16:33:33 A randomized trial of time-restricted eating (w/ intermittent fasting, iTRE) vs calorie restriction or standard care in people at risk for diabetes #T2DM https://t.co/BuyDdOYdJb iTRE best for glucose metabolism @NatureMedicine https://t.co/AoHi0Z0b0K
2023-04-06 15:04:33 The death rate for Covid still markedly exceeds that of flu for hospitalized patients with either virus (6% vs 3.75%), as seen among people age 65+, and higher among unvaccinated, in the @DeptVetAffairs dataset https://t.co/DUNjRkxjp5https://t.co/CTi7bNKQ6Q
2023-04-06 14:00:30 Important new report on #LongCovid and the brain demonstrating persistence of the virus spike protein, throughout the body and particularly the skull-meninges axis, both in humans and the mouse model https://t.co/tcOywXMafL by @erturklab @zhouyi_rong @HongchengM @Sakethkapoor https://t.co/JqISpqaiLi
2023-04-05 21:22:13 These are major triumphs 66 years later after RSV was 1st reported. It is the/a leading cause of pneumonia in young children and older adults. Accompanying editorial by @ruth_karron https://t.co/q7EVzpTnls See importance of prefusion spike stabilization in Feb 15 thread above https://t.co/7DwqRyUvbs
2023-04-05 21:14:31 "But now with these LLMs like #ChatGPT, you see patients going to and asking questions that they’ve wanted to ask their doctors — because...you forget things when you go to the doctor, perhaps because you’re stressed, and because, unfortunately, doctors don’t have that much time"
2023-04-05 21:09:14 "Having #AI as an assistant to the doctor is going to play to the strength of the doctor as an intellectual, compassionate provider of care....I fully anticipate is going to happen in the next year, year and a half"—@zakkohane https://t.co/wp3YpI0BoA
2023-04-05 20:36:09 RT @stephaniemlee: Scoop: A peer-reviewed study claimed that as many as 278,000 people have died from COVID vaccines. It went viral in anti…
2023-04-05 19:52:32 RT @SouaidTarek: 1/ Ever wondered how the 4th industrial revolution (#AI, robotics, and big data) is reshaping healthcare? Let's dive i…
2023-04-05 15:20:37 "#AI-guided assessment of cardiac function in echocardiography was... superior to the initial assessment by the sonographer." Saved time for both sonographers and cardiologists https://t.co/6OBOdfIrxh @Nature @David_Ouyang @bryandhe @james_y_zou @CedarsSinai @StanfordDBDS https://t.co/w1iFM92axJ
2023-04-05 01:27:18 Mask studies, before &
2023-04-04 21:06:11 @inducekarmaaa Maybe you should read the thread before posting......
2023-04-04 19:16:55 Twitter's steady deterioration. As recently documented here by @faizsays and @jeremybmerrill https://t.co/G6835BLBrL It extends well beyond its "For You" timeline https://t.co/ue7YB0VD42
2023-04-04 16:01:35 #GPT4 and #ChatGPT comes to radiology https://t.co/736FIz1rBN "GPT-4 successfully transformed all free-text reports into valid JSON files without error (170/170), which could then be read automatically." https://t.co/JLbBlKXGyi Tested for breast cancer screening advice
2023-04-04 02:06:00 RT @CrabbBrendan: The science keeps moving... Well worth keeping infection/reinfection rates down with existing vax, breathing clean indo…
2023-04-04 00:56:39 It should not be paywalled. Here's the crux of the text https://t.co/NdddNA3EZM
2023-04-04 00:42:48 Finally. @US_FDA approval to make available free 2nd bivalent booster for age 65+ and immunocompromised https://t.co/2D22cuxt9W by @lauriemcginley2 and @bylenasun
2023-04-03 21:55:30 Before we were left with no effective monoclonal antibodies to #SARSCoV2, some real world evidence suggests they were effective in reducing death by 86%, hospitalization by 26%, including immunocompromised people https://t.co/NHDSOz1Xe6 @AnnalsofIM @marroquinoc @UPMC https://t.co/gi0hNBvLns
2023-04-03 17:54:30 A review of nanomedicines for heart and vascular indications "Nowhere is this more evident, important and impactful than in cardiovascular medicine." https://t.co/mcoWBDok3c @NatureCVR https://t.co/ZQCMAgGJ20
2023-04-03 16:07:53 It's very expensive to train #AI large language models, quantified, making this unlikely to be achievable in academic institutions https://t.co/lDNrKtscgVhttps://t.co/5coO3yR4up
2023-04-03 15:45:23 A blueprint for multimodal graph #AI learning https://t.co/zATisTNBZk outstanding perspective piece by @YEktefaie @marinkazitnik @GDasoulas @ayushnoori @MahaFarhat @harvard_data @HarvardDBMI https://t.co/Dr1SkcDJLA
2023-04-03 15:16:13 Important work by @NouaillesLab and colleagues @ewyler @ChariteBerlin @FU_Berlin entering clinical trials https://t.co/uxglb1PmJQ
2023-04-03 15:16:12 A nasal vaccine induced superior mucosal and systemic immunity vs #SARSCoV2 variants compared with mRNA (Pfizer) and adenovirus-vector vaccines by serology, histopathology, scRNA -seq in hamsters @NatureMicrobiol https://t.co/N2DVNyUPIAhttps://t.co/YjsDRUy7aj
2023-04-01 06:11:42 @OpenMedFuture @Twitter @verified @SubstackInc Better business model? https://t.co/G6835BLBrL
2023-04-01 06:06:50 @WorkmanLesley Many thanks
2023-04-01 05:23:14 I'm with @DanRather and so many others who I respect, follow and trust on this https://t.co/x4WaZP1dOY
2023-04-01 03:35:31 Wouldn't pay @twitter for a blue After >
2023-04-01 02:36:29 RT @loscharlos: Spoke with @Nature about how it’s incredibly perplexing for NIH to be prioritizing #LongCovid clinical trials that will add…
2023-04-01 00:30:19 Two more new publications and on #AI for surgery by this outstanding team https://t.co/TK7Rrsdjrq
2023-03-31 20:20:13 RT @MarkELindsay: Pleasure to write this editorial with @EricTopol describing our present and future work applying #AI to genetic and clini…
2023-03-31 20:10:21 Potential concern raised by these variants on T cell immunity https://t.co/bfuUvZKyZb
2023-03-31 20:10:20 Continuation of USA=XBB variants with XBB.1.9.1 gaining and XBB.1.16 (big in India) in the background showing more growth advantage https://t.co/jjl2AnOYb5 Unclear whether any clinical outcomes will be affected by transition from XBB.1.5 to these recombinants w/ added mutations https://t.co/yTXUHM5Sj1
2023-03-31 19:46:08 RT @jburnmurdoch: The result is that the US is the only developed country where even if you strip out all Covid deaths, life expectancy sti…
2023-03-31 02:33:40 Dysmorphic, widened aortas are quite common
2023-03-30 23:51:31 Using #AI to predict and ultimately prevent aortic dissection Our new @TheLancet digital medicine essay https://t.co/zTPk4MtrD6 @MarkELindsay @patrick_ellinor @jpirruccello https://t.co/oqjyHRUTyr
2023-03-30 19:50:42 RT @TCLawry: If you want to move beyond the hype surrounding GPTx and its application to medicine, read this assessment by @EricTopol of a…
2023-03-30 18:33:00 Using #AI to enhance the performance of surgeons https://t.co/qsKA2wMQdQ @natBME @AjhungMD @DaniKiyasseh @Runzhuo_Ma @haqueward @ddonoho @AnimaAnandkumar https://t.co/US3c6GrZdU
2023-03-30 18:20:26 RT @davidrliu: Today we report in @ScienceMagazine a one-time base editing treatment for Spinal Muscular Atrophy (SMA), the leading genetic…
2023-03-29 21:05:00 New @NEJM Marked reassurance that the bivalent BA.5 vaccine is not associated with increased clotting events https://t.co/LurDno0QBD "We previously found no increase in the incidence of stroke, acute MI, or pulmonary embolism after the administration of the monovalent vaccine." https://t.co/u44yk7aVoy
2023-03-29 21:01:00 The @NEJM is getting serious about covering #AI in medicine with a new series and journal. A #GPT4 preview, review and editorial today This important advance is covered in-depth in a new book https://t.co/hGyrJt4yt7https://t.co/NeOeOGtxsb
2023-03-29 18:51:38 Discovery of a "molecular syringe": new way to deliver functional proteins into human cells with very high efficiency that exploits #AlphaFold, #AI, and nature https://t.co/yvlBaXBCZO @heidiledford https://t.co/ImfwywvNJ0 @Nature @zhangf and colleagues
2023-03-29 17:32:23 Is this really worth full page ads @nytimes and @washingtonpost today? https://t.co/QAeHINKBRc
2023-03-29 02:16:38 RT @AI_4_Healthcare: Leave it to @EricTopol to whet my appetite for the next big #AIinHealthcare book. Can't wait to read it. Hey @peteratm…
2023-03-28 21:59:19 "I struggle to understand why the healthcare systems of the world’s richest countries are not yet using all the knowledge that science has provided to bring more help to.. millions of others living with pain." https://t.co/STqC1VB2qh by @lucy_os @Nature https://t.co/YynX6ATaLX
2023-03-28 21:25:23 #ChatGPT is so old Here's what GPT-4 (and beyond) can do for healthcare https://t.co/hGyrJt56iF
2023-03-28 21:20:16 For uninitiated healthcare personnel, #AI can guide obtaining high quality ultrasound images in patients with trauma https://t.co/95o99AYh3v @JAMANetworkOpen https://t.co/xWRu9RRGAH
2023-03-28 20:06:24 RT @LGlaucomflecken: New episode! We had a fascinating conversation with @EricTopol about how AI will affect the medical profession in p…
2023-03-28 02:00:58 RT @chrishendel: This was a fascinating read! The GPT-x Revolution in Medicine by @EricTopol Review of a new book with 6 months of asses…
2023-03-27 22:17:43 I wrote about GPT-4 in medicine and a new outstanding book by @peteratmsr @goldbergcarey @zakkohane coming out soon https://t.co/hGyrJt56iF
2023-03-27 22:13:43 @loscharlos not --1000% thanks to all you are doing to maintain awareness and education with the latest information every single day
2023-03-27 17:57:02 Does regular physical exercise lead to cognitive gains across the lifespan? https://t.co/p1XWeItOJv The causal evidence from the aggregated 24 meta-analyses of randomized trials is "far from conclusive" @NatureHumBehav
2023-03-25 18:07:45 RT @chrischirp: 9. To sum up: Long Covid is real &
2023-03-25 05:46:19 @Brad49M @DelthiaRicks @DFisman @BogochIsaac Yes. Aligns with this report. Real potential for nasal spray broad neutralizing antibodies that will be variant-proof and potentially quite durable https://t.co/Ao7LT6haaV
2023-03-25 03:34:33 @harari_yuval @tristanharris @aza Thanks for cheering us up, Yuval
2023-03-25 00:58:47 RT @LongCovidAdvoc: Yes @EricTopol calling out the Denial Dismissal Unempathetic Biopsychosocial Model of #LongCovid (This includes p…
2023-03-24 22:40:37 The key and under-appreciated dimension of time and our circadian clock in the diagnosis and treatment of cancer https://t.co/k0v8gEcYrk @TrendsCellBio @CellCellPress @ETH_en https://t.co/6NoSlHOsvP
2023-03-24 21:49:41 While there has been progress in ways to reduce the likelihood of developing #LongCovid, there's very little to show for any treatment. Small randomized trials of Paxlovid and Naltrexone are underway. Reviewed here https://t.co/NyRhyCiVJOhttps://t.co/BY30d03eNv
2023-03-24 20:15:21 The potential for inducing pluripotent stem cells (iPSCs) from a person to treat Parkinson's disease, congenital heart disease, and many other incurable conditions is going to be assessed in multiple clinical trials https://t.co/HiCQC1tgFz by @NidhiSubs https://t.co/ddvx3t1z5m
2023-03-24 19:27:16 RT @chrischirp: LONG COVID : Clips from today's @IndependentSage from world leading experts. PLEASE WATCH! 1. @EricTopol We know a LOT M…
2023-03-24 03:48:04 @inducekarmaaa @NewsfromScience @ScienceMagazine @jcouzin Perhaps you haven't read many essays I've written on that very topic. There is NO minimization coming from me. 1 example https://t.co/PcV84bUOwyhttps://t.co/MdHYgerJvw
2023-03-24 03:33:18 RT @zalaly: Paxlovid can prevent #LongCovid The latest from our team in @JAMAInternalMed by @Biostayan @TaeyoungChoi93 @zalaly A thread…
2023-03-23 20:08:42 RT @thehowie: Four principal ways to Preventing Long Covid, with *NOVID* at the top of the list. Great piece from @EricTopol https://t.co/1…
2023-03-23 20:05:06 Summary of data supporting less #LongCovid with Omicron and its subvariants (along with more immunity built via vaccinations, infections, and their combinations) https://t.co/2Z1OxL3w2B @NewsfromScience @ScienceMagazine by @jcouzin
2023-03-23 19:37:33 A prospective, multicenter study of label-free #AI classification of brain tumors (diffuse gliomas) with 93% accuracy in <
2023-03-23 18:24:15 The #SARSCoV2 virus impact on our epigenome https://t.co/T0AxihtgJ9 @NatureMicrobiol may help "pave the way for unraveling the molecular basis of #LongCovid for its intervention" https://t.co/5SNK6JvGTf
2023-03-23 16:33:09 @WBryanH @JAMAInternalMed @substack Yes, vaxxes are spike-specific for inducing antibodies in contrast to full virus exposure (including nucleocapsid protein) from infections
2023-03-23 15:02:00 In @JAMAInternalMed today, 2 new papers on #LongCovid, one a systematic meta-analysis showing protection associated with vaccination--a 43% reduction, and the other with Paxlovid--a 26% reduction I wrote about this w/context in a new @Substack post https://t.co/eARtGCcZyv
2023-03-22 21:04:13 "Coffee drinkers have consistently had reduced morality in prospective cohort studies, but the mechanism for this result remains unknown"
2023-03-22 21:02:32 A randomized trial of coffee consumption showed no increased of premature atrial contractions (PACs). Secondary endpoints (hypothesis-generating): more PVCs, more physical activity, ~30 mins less sleep, no change in glucose levels https://t.co/7KDnmcpcOC @NEJM https://t.co/L9ofCbBsEr
2023-03-22 19:31:22 @dfocosi @ScienceTM Agree on all points, Daniele. There have been several bnAbs with variant-proof potential (not this one) and the concept of multi-year protection via this path is alluring, to say the least, for immunocompromised individuals
2023-03-22 18:41:37 Agree on transformative impact of #AlphaFold but that wouldn't be classified as a LLM https://t.co/7bit917Bfj
2023-03-21 18:26:09 This action is months overdue. The FDA has left people of advanced age and immunocompromised vulnerable https://t.co/n8BLZAPGBj by @StephArmour1 w/ @mtosterholm @BarneyGrahamMD https://t.co/KVLeWZHoKB
2023-03-20 23:07:45 @DocJeffD @AnnalsofIM Exactly. A reason for early termination of the trial and a good news that is reinforced by multiple other reports https://t.co/6iqDJ3oV1b
2023-03-20 22:28:53 @wgpWoman Thank you!
2023-03-20 22:10:28 A randomized trial of a blood thinner after severe Covid to prevent clothing events. Summary of result: "highly compatible with estimates of efficacy ranging from a 56% reduction to a 95% increase risk of apixiban compared with placebo https://t.co/SqsS7OCwKq @AnnalsofIM https://t.co/mZCcbXwKBf
2023-03-19 19:27:38 After the first global reduction of life expectancy since World War II, a path towards "longer and healthier lives" https://t.co/FabQ5X6RsK by @Atul_Gawande https://t.co/vCbA13L490
2023-03-17 22:56:07 RT @JPWeiland: Short-term forecast for the US looking good! XBB.1.5 is receding with nothing to take it's place in the near term, with n…
2023-03-17 18:18:45 @DeepaRamani1 @ScienceMagazine Much appreciated
2023-03-17 18:16:43 @Nancy_had_enuf Thanks for noting. Yes, on Mastodon and Post. But will be using substack as my primary means of getting stuff out. https://t.co/ldL5SfDzdL
2023-03-17 17:35:19 The vital role of patients and the public in guiding #LongCovid research https://t.co/V2xLnrMLIi @NatureMedicine by @AshRouten and colleagues https://t.co/6qif9SHjUB
2023-03-17 04:38:54 RT @TCLawry: If you want to understand where GPT and Large Language Models are taking us in health and medicine, this is the piece to read.…
2023-03-16 22:10:48 @FurnessColin Thanks for your input. To quote the report "the majority of recovered COVID-19 patients had normal olfactory function based on three-year follow-up." I didn't write anything about brain function or tissue
2023-03-16 20:48:05 Loss of smell after Covid: by 3-years (the longest follow-up study to date) >
2023-03-16 20:09:40 The ceramide story and how it may add to cholesterol for gauging risk and intervening for heart disease https://t.co/gFlZfPaWeN @ScienceMagazine https://t.co/MvX8eLmOLA
2023-03-16 18:37:23 Why are so many young people getting colon cancer? https://t.co/fcADufmq22 @ScienceMagazine w/ @ScienceVisuals by @GiannakisLab @KimmieNgMD @DFarberYoungCRC @DanaFarber https://t.co/wtS8RnXzeQ
2023-03-16 18:25:47 One of the most important advances for #AI in life science has been #AlphaFold. The prediction of proteins from amino acid sequences at atomic level has a new large language model, ESM-2, from @Meta https://t.co/Hs4H8wW4eS @ScienceMagazine https://t.co/m9RXmWviu7
2023-03-15 18:24:42 @ScienceTM Distinct and longer term immune protection induced by Prior Covid + vaccination (hybrid immunity) https://t.co/swk5Mz0ove @CIRI_Lyon @CIRI_Bcell_lab https://t.co/IcApu7L3Vm
2023-03-15 16:41:13 An important conversation with @HeartBobH about faculty, freedom of speech, the role of academic Iinstitutions and the Covid pandemic. With @cuttingforstone +transcript @Medscape https://t.co/XevAfk4npk
2023-03-15 16:16:18 RT @sheencr: Today is #LongCovidAwarenessDay LongCovid is a condition comprising often severe symptoms that can affect many different org…
2023-03-14 21:11:17 RT @ScrippsDTC: In this 2009 @TEDTalks, @EricTopol highlights several of the most important wireless devices in medicine's future. Today,…
2023-03-14 20:43:58 Today @GoogleAI's Med-PaLM 2, was just reported to score 85% of the US Medical Licensing Exam, up from 67% a few months ago https://t.co/W1Sz2CMI3C Generative #AI is going to rock medicine I just wrote about it https://t.co/aOWx7kAw4G
2023-03-14 19:50:16 RT @fammedfeisty: A really important read! Especially the part near the end about the potential for AI and LLMs to greatly reduce the admin…
2023-03-14 19:49:10 @j_corey02 https://t.co/DyGfAylUO6 It originally stated, incorrectly, that Eric Topol had declared the Covid pandemic “to be over”. In fact, while Dr Topol stated there are multiple indicators that we are entering an endemic phase of the pandemic, he does not believe the pandemic to be over
2023-03-14 17:10:24 The remarkable story of @DrFejzo's perseverance to find the biologic basis for a condition she suffered from and to help establish leadership and advocacy for it @HGMoms https://t.co/bBmEm3pueX by @scienceofmom
2023-03-14 01:24:15 On the mission of communicating science and medical information to the public. A newsletter about this Ground Truths newsletter and an announcement about where it's headed. All proceeds to be donated to @ScrippsRTI @scrippsresearch https://t.co/ldL5SfDzdL
2023-03-13 23:48:00 @annbmcguire123 Thanks! And @dr_kkjetelina is a gem
2023-03-13 23:29:38 @LLColorMeBlue Much appreciated!
2023-03-13 23:10:00 AI isn't "superhuman intelligence" but it's interesting that humans can up their game by learning from it https://t.co/6J619boqDu @PNASNews @jinkimsci @basvanopheusden @cocosci_lab https://t.co/M5PaDcUwqF
2023-03-13 22:59:19 A new and very good review on the emerging impact of #AI for cancer diagnosis, prognosis and treatment https://t.co/0o2Fyn2btP @CellCellPress @KyleWSwanson @ericwu93 @AshAlizadeh @james_y_zou @StanfordMed @StanfordEng https://t.co/Z5fweUWZpP
2023-03-13 21:43:24 RT @SubstackInc: "Unfortunately the toxicity of twitter has progressively gotten worse, while at the same time the ability to reach followe…
2023-03-13 14:29:08 35% of hospital admissions with medical errors/ adverse events, according to an 11-hospital Massachusetts study. Some are being addressed with #AI tools https://t.co/IOSULOeWit by @LauraALandro https://t.co/OymOwpZdbu
2023-03-12 22:32:36 @DrMaireadDB @j_corey02 @AlanEnglish9 @Independent_ie @PatKennyNT @NewstalkFM Thanks. I notified @PatKennyNT @NewstalkFM as well
2023-03-12 22:07:32 RT @zalaly: @EricTopol @ScienceMagazine @NEJM This is absolutely on point. One of my favorite quotes from an Op-Ed @EricTopol wrote in @…
2023-03-12 21:19:45 Despite an estimated 10-20% of an "Omicron-like event" in the next 2 years, as I reviewed here https://t.co/qTgIEjnydz Hard to find any major initiative to develop better Covid vaccines for broader, more durable protection &
2023-03-12 21:01:16 There are over 50 published papers that identify such candidate "universal" vaccines or potent broad neutralizing antibodies that can be used as a template for such vaccines. A sampling below https://t.co/QzLzYEGTGX
2023-03-12 20:51:56 In 2021, there were urgent calls for a universal coronavirus vaccine https://t.co/V71aBHAKlr @ScienceMagazine https://t.co/XsOwK7Pcnx @NEJM There is little to show for this, despite abundant candidates vs β-coronaviruses (#SARSCoV2 variant-proof) https://t.co/tss9IivpnA
2023-03-12 17:15:16 @j_corey02 Thanks Julia. I have written to @AlanEnglish9 demanding a correction about this misinformation @Independent_ie
2023-03-11 20:08:08 RT @EricTopol: My conversation this week with Prof @linseymarr, a civil engineer and leading authority on air quality, viruses, and the imp…
2023-03-11 15:58:24 @BiffAndFinn @Mirella_PhD @brownecfm Dr. Mirella has made a repeated false accusation that I deleted a tweet--which I did not. And thank you for explaining the lack of need for "damage control," another bogus assertion she has made.
2023-03-11 00:59:42 There's a lot of confusion about what a Covid endemic phase means. I think this short essay by @ArisKatzourakis @Nature is the best description I've seen https://t.co/J16ZGW86lu "a disease can be endemic and both widespread and deadly" https://t.co/5saXi5Q9z7https://t.co/e2MPzrrSPH
2023-03-11 00:24:01 RT @brownecfm: 1. This is a must-read from Irish journalist, Tess Finch-Lees, dissecting the recent declaration from Professor Luke O'Neill…
2023-03-10 20:43:41 Yet another pan-sarbecovirus (#SARSCoV2 variant-proof) vaccine candidate, this one with effective neutralization vs the BQ.1.1 and XBB variants in non-human primates https://t.co/ftkVFKAYP5 @PNASNews Bu none of these have progressed to clinical trials https://t.co/YratTfR9fU
2023-03-10 17:23:48 More on this, including declaration from @cochranecollab director that their review interpretation was "inaccurate and misleading" https://t.co/eRAbEAIq6C @nytopinion by @zeynep
2023-03-10 13:48:20 @MichaelColey @MichaelSFuhrer That's correct. I did not say/write "the pandemic is over"but that it appears we've entered an endemic phase (think wavelets rather than major waves). And i reviewed the current high baseline of adverse outcomes and risk of a new major variant family https://t.co/qTgIEjnydz
2023-03-10 03:18:49 @JusDayDa @Twitter That’s what I heard now from hundreds of people who follow me
2023-03-10 03:11:34 This one and most of my @twitter posts are being suppressed from being seen by followers. Whether it’s attributable to intent or default is unclear. I’ve been on this platform for 13.5 years and the ability to share information is now significantly impaired
2023-03-10 00:03:43 3 years in, the status of #LongCovid Editorial @TheLancet "Progress has been excruciatingly slow due to lack of attention and resources" https://t.co/qdQ9nF2Uonhttps://t.co/fxauyKYAAr
2023-03-09 23:26:40 @Sara_Sawyer_ @ScienceMagazine @ScienceVisuals @CJayWarren That kicker was powerful! Great and much needed piece
2023-03-09 22:18:22 @covid19_alex Many thanks
2023-03-09 21:22:27 @EcoSexuality Yes
2023-03-09 21:15:48 On Pandemic preparedness "Given the profound consequences of virus epidemics and pandemics, and the highly flammable tinder of 8 billion people crowded onto the planet" @ScienceMagazine w/ @ScienceVisuals https://t.co/gZRFmIr0mQ by @CJayWarren @Sara_Sawyer_ https://t.co/UF8gm5VGjm
2023-03-09 20:55:02 Beyond a month post-Covid, there's a significantly elevated risk of clots, including heart attacks and strokes that has been established by multiple studies, with reduced risk among those vaccinated https://t.co/6iqDJ3oV1bhttps://t.co/7bXyGZiugc
2023-03-09 20:46:26 A prospective study implicating the gut microbiome and its interconnected immune response for hospital-acquired infections https://t.co/MB82FjpscM @NatureMedicine https://t.co/UzrLLZmX1k
2023-03-09 19:46:36 Update: People age 65+ are now eligible to participate https://t.co/2FHe53TKeI
2023-03-09 16:21:29 Current treatment of blood pressure, the most common chronic medical condition, is hit or miss, with multiple drug classes and frequent lack of adequate control. What if relevant gene variants were screened? https://t.co/ohpGLuHpkN @ScienceTM https://t.co/JxDDhL04Tj
2023-03-09 16:04:27 The effects of radiation therapy Bad: Heart
2023-03-09 15:47:56 piece is by @adampiore (not adampio)
2023-03-09 00:38:53 RT @ahandvanish: This is so exciting (not as a brag!), but because it concretely shows huge increased interest in #LongCovid, including by…
2023-03-08 23:59:01 A new systematic review of the Covid pandemic's impact on mental heath provides some reassurance from an aggregate of 137 unique reports https://t.co/6Ir0pMPB0g @bmj_latest https://t.co/NwBlwqeUH6
2023-03-08 19:22:54 The impact of pandemic school disruption (cohort, grades 7-9, in Germany), with the intelligence test gap in results persisting out 16 months https://t.co/yhfbrZZp51https://t.co/pR9Sbp1PuP
2023-03-08 18:52:56 Our #LongCovid review @NatureRevMicro has surpassed 10,000 @altmetric and 670K downloads @ahandvanish @LisaAMcCorkell @julialmv https://t.co/EgO7gtFvoehttps://t.co/IJukoucvgE
2023-03-08 17:12:08 Along similar lines https://t.co/igjwQB4miX @TheAtlantic by @jdkstern13 "Either ChatGPT will completely reshape our world or it’s a glorified toaster.... the rest of us sit quietly somewhere in the middle, trying to make sense of this strange new world."
2023-03-08 17:07:47 Discovery of specialized neurons in the upper airway that, when removed, disrupted sickness from a respiratory virus, similar to the effect of ibuprofen or aspirin https://t.co/RGpFboFRbY @Nature @justsaysinmice @HHMINEWS https://t.co/NmRi1e8rN5https://t.co/dP3nF9uS0i
2023-03-08 14:54:34 The —is bigger better ?— for LLM #AI When #ChatGPT and large language models get exponentially bigger (such as GPT-4 at 100 trillion parameters), will they perform better? An outstanding @nature feature https://t.co/efnazvOKBi by @anilananth https://t.co/TJMx1blJM4
2023-03-07 20:01:20 A nasally administered monoclonal antibody in patients with mild-to-moderate Covid for favorably modulating the hyperactive T cell immune response https://t.co/ZdkvYN74Ta @PNASNews https://t.co/IFoLSgsK53
2023-03-07 18:58:08 Indoor air quality: We're not paying attention to it or doing anything substantive about improving it. It's long overdue to get serious and all over it. a new @Nature feature https://t.co/k2LB6MkYN2 by @dyanilewis https://t.co/17vy1yURSg
2023-03-07 17:25:27 RT @EckerleIsabella: All true at the same time: 1) #SARSCoV2 is entering an endemic phase, new variants not causing massive infection waves…
2023-03-07 16:39:36 @DKMedJournalist That's not the correct interpretation. The 95%CI are overlapping (below age 45 and above) and there is not a treatment by age subgroup interaction.
2023-03-07 16:06:20 Here's a good summary graphic and highlighted abstract https://t.co/NWKZJrOKIW
2023-03-07 15:58:55 The gastrointestinal impact of #LongCovid https://t.co/2lk7cJ0qsR by @zalaly and colleagues Just published @NatureComms Broad risk of GI adverse outcomes after 30 days, worse with severity of Covid, but clearcut increased predisposition even in those without hospitalization https://t.co/W7aneWVcK2
2023-03-07 15:21:22 @Bob_Wachter Given the lack of side effects and cost for a 2 week course, I think these data support use of metformin now. We do need more studies (for a solid replication), factorial design w/ Paxlovid. There are no subgroup treatment interactions so unclear how to partition its use
2023-03-07 14:53:55 @Rob_Messinger Thank you!
2023-03-07 14:38:41 Front page @latimes AT least 95 passages of plagiarism in a #1 @Amazon book (subtitled "Nature's Lessons for a Long and Happy Life") https://t.co/6JVSLNiQFBhttps://t.co/btGUjhqH44
2023-03-07 01:59:58 For a total takedown of the @cochranecollab report See @tomaspueyo https://t.co/0dp9FSwQ3X For the full body of evidence on masks See @trishgreenhalgh https://t.co/h0pUsWeYeb
2023-03-06 23:40:35 @CDCgov_parody @BramanteCarolyn I do.
2023-03-06 23:06:33 Genetic conditions involving impaired Type 1 Interferon response predispose to severe COVID pneumonia (previously thought to only promote susceptibility to bacterial infections) https://t.co/jF8KENVYYf @JExpMed https://t.co/qU4wF7GmNq
2023-03-06 19:16:32 Dose of metformin: 1 pill (500 mg) day 1, twice daily for 4 days, then 1 in AM, 2 in PM for 9 days Cost as low as $1. https://t.co/iSK9IYrjar
2023-03-06 18:35:16 Very good news Metformin significantly helped prevent #LongCovid in a placebo-controlled randomized trial, a 42% relative reduction https://t.co/go20dm3NnN by @BramanteCarolyn and colleagues https://t.co/4uUZVINq62
2023-03-06 16:15:16 Self-directed Abs (autoantibodies) against specific chemokines (cell secreted proteins) are linked with protection from #LongCovid https://t.co/2dsP0ifxq4 @NatImmunol https://t.co/80uncmfTSp
2023-03-06 15:56:47 RT @EricTopol: We've known that Covid can predispose towards clots. But what about late effects, months after an infection? A summary of th…
2023-03-05 16:54:58 The potential for #AI to predict flares in patients with ulcerative colitis as well or better than pathologists in a multicenter prospective study #IBD https://t.co/Lw3PYpj2hO @AGA_Gastro by @MariettaIacucci @tommasoparigi and colleagues https://t.co/l7Msqr4ewu
2023-03-05 16:39:30 Smartphone imaging to detect anemia in a vulnerable, understudied pediatric population with sensitivity 93%, specificity 90% in a small cohort https://t.co/7PfeKiHfgf @thomas_wemyss and @UCL @UnivofGh colleagues @PLOSONE https://t.co/yH7UlJQEFG
2023-03-05 16:05:18 We've known that Covid can predispose towards clots. But what about late effects, months after an infection? A summary of the evidence that has been recently updated https://t.co/6iqDJ3oV1bhttps://t.co/RsoxU166Yr
2023-03-05 10:00:00 CAFIAC FIX
2023-03-02 22:00:00 CAFIAC FIX
2023-02-28 02:54:05 @JN1171 @cmyeaton @dr_kkjetelina Much appreciated!
2023-02-28 00:38:19 A fun visit with 2 great epidemiologists today @cmyeaton and @dr_kkjetelina giving a little tour of La Jolla cove https://t.co/0S2WqqCB5X
2023-02-28 00:04:21 This is a unique "bedside to bench to model" study (starting with affected patients to RNA-seq to experimental model) for #LongCovid and may help identify specific candidate anti-inflammatory therapies
2023-02-27 20:35:30 Towards understanding lung scarring in people with #LongCovid and potential treatment https://t.co/mJtlBvKskn Single cell RNA-seq used to identify specific markers (e.g. IL-6, CD47) and blocking these in a humanized mouse model to decrease lung scarring @PNASNews @GerlindeWernig https://t.co/qLEK4TNdtE
2023-02-27 18:14:50 The UK has led the world in human genomics. Can it further become a science superpower? https://t.co/gvzuSDhOyU new editorial @ScienceMagazine by @jameswilsdon https://t.co/OpeqEKSiBg
2023-02-27 17:30:00 RT @tomaspueyo: Do masks work? Recently, some ppl have started claiming it's proven that they don't. Is this true? I dove into the detai…
2023-02-27 16:30:47 The persistent excess of cardiovascular deaths in the United States through the 1st 2 years of the pandemic, consistent throughout 5 Covid waves, even well after surges in cases waned https://t.co/6oXy15KX47 @NatureCVR https://t.co/InSmk1C4v4
2023-02-27 16:18:52 Summary of the multiple recent reports that support autoimmune component of atherosclerosis https://t.co/CW7cKLF9sH @NatureCVR @AndreasEdsfeldt https://t.co/xpweW6l2FS
2023-02-27 16:06:14 A new report from Canada on Covid vaccine related myocarditis in teens among 1.65 million doses (77 cases) https://t.co/yjsfU2o0TY @JAMAPediatrics "the risk of these events remains very rare" reduced further by longer interval to 2nd dose https://t.co/3KY19VeE0P
2023-02-20 17:28:20 RT @CraigJoseph: Thorough overview by @EricTopol of the history of hospital-at-home, the impact that #COVID19 had on #HaH, and what the fut…
2023-02-20 17:20:20 What if you could remove APOE4, the most important genetic risk factor for Alzheimer's disease, from the brain? They did https://t.co/KjSdgdukym @NatureAging by @GladstoneInst @justsaysinmice https://t.co/ycPrG7q219
2023-02-20 16:53:52 The @JAMA_current Editors weigh in on this new trial and the body of evidence that all points to lack of Ivermectin benefit https://t.co/3wCxBV92Sd by @KBibbinsDomingo @PreetiNMalani https://t.co/QXCXuTLFBr
2023-02-20 16:49:04 Nearly all Paxlovid drug-drug interactions can be circumvented by holding the drug or reducing its dose. A quick and practical summary @JAMAInternalMed https://t.co/Fi3Vmxn9fY
2023-02-20 16:18:37 Covid vaccination is associated with significantly reduced incidence of heart attacks and strokes during follow-up. Results of a nationwide @ncats_nih_gov study https://t.co/YsfQ3Olqj0 @JACCJournals https://t.co/H8YvtDAOyJ
2023-02-20 16:06:00 This comes after @cochranecollab review of all evidence from 11 trials + 3 recent randomized trials that were all negative. There are still >
2023-02-20 16:01:31 A new Ivermectin randomized, placebo-controlled trial at high doses for long duration fails to show any benefit, published @JAMA_current today @snaggie1 @boulware_dr and colleagues https://t.co/PyT6k8Q5Jmhttps://t.co/oe227wjFtF
2023-02-20 14:50:30 Our digital times :-) by Hartley Lin and @MatttDavies https://t.co/DPmjlSZoIF
2023-02-20 01:56:34 RT @NHLBlackhawks: A statement from Captain Jonathan Toews https://t.co/tn7CP57bQN
2023-02-20 01:16:52 These 2 papers were the most impressive life science achievements of the week (if not much longer). I wrote about their significance and the remarkable progress that is being made in the field of genome editing https://t.co/EGCvhT76ld
2023-02-19 22:45:26 If you want to read about some really exciting biomedical genome editing stuff https://t.co/EGCvhT76ld
2023-02-19 16:39:16 @wunschcritcare Yes, it was your brilliant book I reviewed for Nature.
2023-02-19 01:40:05 @AndrewLBeam @zakkohane @NEJM @arjunmanrai Says a lot about AI in medicine when @nejm starts a dedicated journal
2023-02-19 00:57:20 I just finished a book on the history of polio. It made me think of some interesting contrasts and similarities vs #SARSCoV2 https://t.co/wDlWaeU0zR
2023-02-18 17:12:27 Two-thirds of people age 65+ have 2 or more comorbidities. Graph of in-hospital mortality in males by age groups. A "dose response" of comorbidities on top of age. Reduced physiological reserve a key factor. "Inflammaging" discussed. https://t.co/bbTJchkrnE
2023-02-18 17:12:26 A new and astute review of comorbidities and Covid, with attention to causality and biases https://t.co/4unhpohrbX @NatureMedicine by @clarkdrussell @ICULone @kennethbaillie Their influence varies considerably by the 3 phases of illness. #LongCovid least impacted https://t.co/RXrHVUi4LM
2023-02-17 21:21:21 When we think of the immune system, antibodies and B &
2023-02-17 18:00:37 On a related front, the definitive review on autoimmune neurologic diseases https://t.co/nXVi8Dufx0 by @darshi_r @RussellCDale and colleagues @NatRevNeurol https://t.co/Kbo0JIyiF4
2023-02-17 16:48:00 This is the best and up-to-date paper (preprint) I've seen on transformer models, what's generating the LLM buzz in #AI now https://t.co/lVeZ1BooTA by @xamat https://t.co/y4Isg5Xf8M
2023-02-17 16:04:17 XBB.1.5 now dominant is all US regions without an uptick in hospitalizations or deaths in recent weeks https://t.co/fOz9luTlTo
2023-02-17 15:03:13 When large language models make the headlines https://t.co/MrICIzKqwT "The A.I. Isn't Ready for Humans" It's worth reading @kevinroose's full 2-hour transcript for many reasons, including conversation length has now been cut by @Bing https://t.co/dtZy8MjwL0
2023-02-17 14:51:27 From the Lancet paper, the difference in health care policy for prior Covid in the US and other countries https://t.co/VUJpaTSIrB
2023-02-17 14:51:26 A year ago I wrote about the failure of the US to acknowledge the protection afforded by prior Covid https://t.co/a7bue4mMgW
2023-02-17 00:28:58 Good summary for infection-acquired immunity. The unpredictability of a Covid infection with respect to inducing severe disease and chance of developing #LongCovid https://t.co/20YnGjtgPW
2023-02-17 00:06:34 RT @WesElyMD: 1/The Haunting Brain Science of Long COVID Here I use science to raise awareness of a growing public health nightmare hid…
2023-02-16 23:47:02 Link https://t.co/CVIyJDjF74 Graph shows comparison vs vaccination for different outcomes over time Conclusionpulls a lot of data all together Work by @IHME_UW team https://t.co/ucnoWJ0SB8
2023-02-16 23:47:01 New @TheLancet Prior Covid provided high protection vs severe disease, including Omicron BA.1 ( ~90% at 10 months post-infection), as determined by systematic review of 65 studies Protection vs reinfection was high (~78% at 10 months) until Omicron,to ~44% w/ more rapid https://t.co/DfuwoSFaW3
2023-02-16 23:12:45 Muscle biopsy in-depth assessment in people with #LongCovid w/ exercise symptoms compared with 2 control groups shows microvascular abnormalities with reduced capillaries, immune cell dysregulation, distinct gene expression signature https://t.co/ngv2vKhcLn @ChariteBerlin https://t.co/ED8OJ2zNQ2
2023-02-16 20:17:11 RT @JenSeniorNY: Can we discuss long Covid for a sec? I know: You're over it. I was too, until I got it. I'd now like to talk...etiquette.…
2023-02-16 18:09:38 Beyond an association, as established in many previous reports, evidence from Mendelian randomization that Covid can cause atrophy in specific brain regions https://t.co/NnMdcdIxuVhttps://t.co/IBeXhzZMFa
2023-02-16 17:05:52 A 2nd @NatureMedicine report today showing prevention of hypertrophic cardiomyopathy in mice via genome editing, reinforcing the potential of a single-dose to cure the most common genetic heart disease https://t.co/S8lqnjRyJt @davidrliu @danielreichart3 and colleagues @harvardmed https://t.co/Q4c7IJjApb
2023-02-16 16:53:39 Exciting to see genome editing of hypertrophic cardiomyopathy to correct the pathogenic variant in the humanized mouse model, laying the groundwork for a potential cure in the future https://t.co/mB4obCSMnJ @NatureMedicine @Transactivator @andreas_c_chai @UTSWNews https://t.co/6i5yvXF4jQ
2023-02-16 16:43:08 Two new prospective studies of #LongCovid --59% organ impairment at 1 year https://t.co/v1YXyYMITb -->
2023-02-16 15:04:21 This work to understand prefusion stabilization for RSV helped set the foundation for very rapid Covid vaccines using the 2-P (proline) substitution that stabilized the spike protein before entering cells, making it much more immunogenic.
2023-02-15 22:20:59 Why did it take so long to get these effective vaccines vs. RSV? It took structure-based design to stabilize the prefusion protein, as shown below, and nicely explained by @BarneyGrahamMD https://t.co/SDxXuKSjIshttps://t.co/WuIGN5qbQB
2023-02-15 22:06:56 The RSV virus was discovered in 1956 and sequenced in 1982. Only now do we have effective vaccines. Today @NEJM results for age 65+ randomized trial https://t.co/SuyAu9E516https://t.co/HloAhDADV2
2023-02-15 19:10:01 Link @ScienceTM https://t.co/mxwylkjo6H Nice #AI work by @NimaAghaeepour and colleagues @Stanford to predict newborn outcomes @StanfordPeds @StanfordPain @StanfordOBGYN https://t.co/iCarPFNaYt
2023-02-15 19:10:00 "Using 2 cohorts w/ a total of 27,000 mothers linked to more than 32,000 neonates, and validated externally with more than 12,000 newborns, we demonstrated the ability to serially and comprehensively predict neonatal outcomes from various maternal conditions extracted from EHRs." https://t.co/KH80B8YUNe
2023-02-15 14:37:52 The first disease-modifying drug for autoimmune, Type 1 diabetes, to forestall its onset, represents a big first step towards preventing such conditions from ever manifesting https://t.co/YnRUdOPtrg @Nature @ElieDolgin https://t.co/H4umWEnJKV
2023-02-15 05:20:24 RT @BenLGreenberg: @EricTopol @doximity Thank you Dr. Topol! So proud of DocsGPT - Conceived and built by @doximity folks far more talente…
2023-02-15 01:46:18 It isn't taking long for #ChatGPT and large language models #AI to help physicians deal with insurance companies! @BenLGreenberg and team @doximity is all over it https://t.co/hRxorApIB8https://t.co/9gruAX3Utz
2023-02-14 23:51:55 Succinct full text reviews the different underpinnings, the unmet needs (a lab test, distinct subtypes, validated treatments) and recognition of patient led research https://t.co/rgfhCJmz13
2023-02-14 20:13:58 The difference in T cell response for autoimmune conditions, response to infection, and cancer. From a new review @ImmunityCP https://t.co/QYeqcBIQsP by @Dr_ImmunoMan_D @AnaAndersonlab https://t.co/nxpYzIN0CA
2023-02-14 16:53:14 A new study @CedarsSinai with association of higher diabetes risk after Covid (adjusted odds ratio 1.58) and reduction with vaccination https://t.co/7poBVuKzOx @JAMANetworkOpen https://t.co/RTmz6B1zmY
2023-02-14 01:47:49 RT @jonirutter: Thanks @EricTopol for highlighting this important piece by @AmyDMarcus w/ @LisaAMcCorkell. Some resources to help are here…
2023-02-14 01:12:59 RT @TCLawry: A great read (as always) from Eric Topol MD on the need to pull forward the Hospital-at-Home movement. @EricTopol #HaH #hos…
2023-02-14 00:06:31 New Ontario, Canada report of Paxlovid effectiveness shows 44% reduction of hospitalizations, 51% reduction of deaths (point estimates) without being significantly affected by age (67% age 70+) or vaccination status https://t.co/b3AQq8tmax @CMAJ https://t.co/3xej0K2xIm
2023-02-13 23:55:15 Accompanying editorial https://t.co/FUguodHuql "Given that no association was found between oral antiviral treatment and viral burden rebound ... emphasizes the importance of continuing to offer antivirals to individuals with COVID-19 who are at increased risk of progression.." https://t.co/8VwcVU9XgZ
2023-02-13 23:49:22 Lack of evidence of overall Paxlovid viral or clinical rebound in a hospitalized cohort, with subgroups identified at higher or reduced risk https://t.co/lNcuVBLzAb @CarlosWongHKU @bencowling88 @gmleunghku @TheLancetInfDis https://t.co/IsPpKzAnw0
2023-02-13 22:16:54 A long held general perception is that adults with type 1 diabetes tend not to be overweight. A new @AnnalsofIM publication of a national sample challenges that view https://t.co/J9zA25dQwj @JohnsHopkinsSPH https://t.co/1Pr0vgoLJD
2023-02-13 16:18:47 Real-time, 3D tracking of the gastrointestinal tract via a wireless ingestible microdevice https://t.co/gcJ8qF1APH @NatureElectron @Caltech tested in large animal models https://t.co/M04vwrU96P
2023-02-12 18:22:42 The 1st survey to assess public views of polygenic testing of embryos before implantation (commercially available in the US without data to supports it use) had surprising results @ScienceMagazine this week Excellent explainer thread below, by the report's first author https://t.co/uDbhhUbgeehttps://t.co/Lk5VM1pdb0
2023-02-12 17:49:43 @danielalamasmd "....this staggering scientific advance has left them facing existential questions." https://t.co/tc9aVZ8rcN
2023-02-11 17:36:52 @AditGinde The sensitivity analyses (as commented by the editorialists) you did to understand the missingness in test date are important. Since there are innumerable critics of the day 0 imbalance, it would be great for you to lay this out in a thread https://t.co/BQy1MOca51
2023-02-11 16:08:44 Accompanying editorial https://t.co/vsJPj094Uc by @CarlosWongHKU and @gmleunghku For those brilliant critics of the day 0 effect, read the paper https://t.co/DH8U6dd7cn
2023-02-11 15:56:04 A review of 68 vaccine effectiveness studies: Preserved protection vs hospitalizations and deaths out to 6 months, substantial waning vs infections, especially Omicron
2023-02-11 15:45:50 As we're seeing w/ #LongCovid, it's essential for researchers to work closely with patients to make progress, democratizing medical science https://t.co/LmKqgH723V by @AmyDMarcus w/ @LisaAMcCorkell @patientled "We consider patients as researchers"— @jonirutter @ncats_nih_gov https://t.co/Jdd9VGPH0S
2023-02-11 15:16:52 A new #LongCovid deep assessment of the immune response confirms dysregulation, exhausted CD8+ T cells, uncoordinated humoral-cell arms https://t.co/hIIoSyajeK @GladstoneInst @UCSFMedicine Previous report https://t.co/jFbxvgWLUP @VirusesImmunity @PutrinoLab https://t.co/prZuUlBLWA
2023-02-11 01:07:42 RT @agingdoc1: When M.D. is a Machine Doctor Helping medical doctors and patients in the Foundation Model A.I. era Excellent discussion b…
2023-02-11 00:22:25 @AstroKatie @TheLancetInfDis It's very unusual for any drug to do better in the real world (via effectiveness studies) than in randomized, placebo-controlled clinical trials. Now that we've seen this broad benefit replicated multiple times, I'd say yes (made available)
2023-02-11 00:11:22 Very low rate of clinical relapse (aka rebound) "Using emergency department visits as a surrogate for clinically significant relapse ...., we observed a *lower* ED visit rate in patients treated with nirmatrelvir–ritonavir [3.9%] compared with untreated patients [4.7%]"
2023-02-11 00:06:06 A new real-world effectiveness study documents 85% reduction of deaths and 55% reduction of hospitalizations for Paxlovid, independent of vaccination status, age, variants https://t.co/9Hu7W6NPs3 @TheLancetInfDis https://t.co/D7TGUvPCYf
2023-02-10 20:43:27 @kyle_carm Community levels (below), a formula defined by the CDC website, are different from transmission https://t.co/6ZN3NXbhwW
2023-02-10 20:30:05 RT @NSpottiswoodeMD: What a delight to talk about unbiased diagnostics and amoebic brain infections with the awesome @ronwinslow at the @WS…
2023-02-10 19:34:49 "Metagenomics is the future of medical diagnostics. It should be the present, but not many hospitals are equipped to do it." https://t.co/bi8eExQbxX @UCSFHospitals @UCSFMedicine by @ronwinslow More here (A Culture of Cultures): https://t.co/Y8eZSBt3dQhttps://t.co/LsyGgUl2d3
2023-02-10 17:57:31 RT @hholdenthorp: My column that builds on the great editorial from Shirley Malcom and @sudipsparikh about graduate student and postdoc sal…
2023-02-10 16:59:02 Some common underpinnings of #LongCovid with multisytem inflammatory syndrome in children (MISC-C) https://t.co/gdgV4JoNOL Persistent virus/remnants, dysregulated immune cell activation, multisystem involvement, autoantibodies, delayed response @ScienceMagazine by @BrodinPetter https://t.co/G0HEm5FJnl
2023-02-10 15:48:10 Outside the Northeast region during XBB.1.5's rise, there was no surge in hospitalizations, now below 30,000 nationally. Deaths have come down from ~500/day, but still alarmingly high with a substantial proportion preventable https://t.co/1gAUEnzRZQ
2023-02-10 15:37:37 All regions are XBB.1.5 dominant except the Northwest https://t.co/hl2s2kN6kT
2023-02-10 15:37:36 The XBB.1.5 variant now accounts for ~75% of new cases in the United States, with no other variant showing gains (including CH.1.1) https://t.co/jjl2AnOYb5https://t.co/PpqPgz8atN
2023-02-09 21:06:14 Discovery of a new receptor for the #SARSCoV2 spike protein (LRRC15) that binds to the virus like molecular Velcro https://t.co/D8WbwEvjGp @PLOSBiology @Neely_Lab @LLTheResearcher @Sydney_Uni and colleagues
2023-02-09 17:03:21 An inhaled hydrogel shield coats the airway to prevent Covid infections, yet another way to get ahead of this virus, no less other respiratory pathogens https://t.co/UhWJ61IFEi @NatureMaterials https://t.co/E9q8ZsYf8t
2023-02-09 16:48:05 Long term caloric restriction: a small effect on biologic aging, as assessed via DNA methylation markers in a randomized trial of healthy adults @NatureAging https://t.co/OBBmA3RRu3https://t.co/M9ebUU5v1n
2023-02-09 14:57:38 “The pandemic after the pandemic” Today’s @washingtonpost editorial on #LongCovid https://t.co/8gjEK16dao
2023-02-09 14:35:34 RT @EricTopol: Interferon λ, a new way to cut hospitalizations by 50% after Covid, in a randomized, placebo-controlled trial >
2023-02-09 03:03:09 It is frankly pathetic that this treatment will unlikely be available in the US, based on FDA regulatory and financial issues https://t.co/GzTIylaxam @benjmueller “I don’t know of any virus that can navigate a cell where interferon got there first”--@virusninjahttps://t.co/19lTWBKWUs
2023-02-09 01:23:53 It took over an hour to post this thread when Twitter was down and I almost gave up. But persisted because I think it’s quite a significant finding that broadens our potential (currently very limited) out-patient treatments
2023-02-09 00:02:15 Why are doctors so polarized about Covid treatments (HCQ, ivermectin, vaccines)? https://t.co/WaBCVuGe3Y "The preference for @FoxNews is a significant predictor of 8 outcomes (controlling for political ideology)" "Political ideology colors the evaluation of scientific evidence" https://t.co/VYECDMsvFx
2023-02-08 23:00:38 And as seen here and in the new trial report, viral clearance was accelerated https://t.co/9izufULZ2I
2023-02-08 22:56:01 A single dose injected under the skin No increase in adverse events cf placebo Some key data summary points below https://t.co/YY0dYVqbfg
2023-02-08 22:56:00 Consistent across pre-specified subgroups, notably vaccinated (84%) and the unvaccinated https://t.co/Bovuyn71hq
2023-02-08 20:11:07 @_Eric_Reinhart @nytopinion @NewYorker Much appreciated, Eric. Your oped was so powerful, folding in the last few years of Covid, and deeply reinforcing the need for universal healthcare. If only we could use our collective power, as you aptly put it, to achieve the changes so desperately needed
2023-02-08 17:25:20 Abnormalities of the gut microbiome in myalgic encephalomyelitis #MECFS in 2 cohorts and controls https://t.co/1mVV4RuB9W @cellhostmicrobe implications for #LongCovid too https://t.co/ZjvWWINRdX
2023-02-08 17:13:50 The search for missing heritability and a new report of ~400,000 exomes on rare/ultrarare coding variants https://t.co/39BWeJDdOG Rare variants contribute relatively little at pop level @Luke0connor @broadinstitute @danweiner92 @NadigAjay @nature https://t.co/sSPduscYRahttps://t.co/SSgYVqSm74
2023-02-08 16:57:06 Agree with @JoannaStern "A big change is coming to how we get information and how we interact with our computers." https://t.co/kbsj8hVEwv @Microsoft @bingc #ChatGPT https://t.co/R6ygqmTsVo
2023-02-08 15:50:02 Good news that there are no new #SARSCoV2 variants detected in China to date: @TheLancet report from ~3000 sequences (mainly BF.7 and BA5.2). Just from Beijing, thru 2022, and only a snapshot, so genomic surveillance is a work in progress https://t.co/cw7jkH5yP0https://t.co/hLDt5UtWrh
2023-02-07 23:56:05 @JusDayDa @Microsoft @bing @CadeMetz @KYWeise Yes, I wrote about that https://t.co/2Axg5C4HtT
2023-02-07 22:51:38 In 2020, @ConsumerReports's investigative work showed @GoodRx was sharing medication data to tech companies w/o user permission https://t.co/qFq10QZe4o That was just the beginning->
2023-02-07 18:42:09 —I'd like to accurately sequence DNA and epigenetic modifications simultaneously —No problem, here you go —Are you kidding? —No https://t.co/cB6cBk8Xpo @NatureBiotech @Joanna_Holbrook @CEGX_news @walraj @paidicreed @ChemCambridge @Cambridge_Uni https://t.co/eO54Ecl5vp
2023-02-07 18:15:45 One end of the LLM user spectrum from @Nature link above re: @haffi67 https://t.co/TE8fQDvU0w
2023-02-07 16:29:20 Good to see the first #AI randomized controlled trial for enhanced chest X-ray detection of lung nodules in screening >
2023-02-07 16:14:42 Direct-to-consumer drug ads: the less a drug's clinical effect, the more spent by the drug companies https://t.co/vaR3VTUyQd @JAMA_current They should be banned. And so should "further research is needed" in the conclusion. https://t.co/NXL6fh7YEL
2023-02-07 15:50:45 Reviews the biology known about IgG4, difference seen with adenovirus vector vaccines. Conclusion highlighted below https://t.co/z26fZzHryc
2023-02-07 15:35:50 A tour de force review on engineering T cells https://t.co/N9BgKZPsud by @lenghan_bioinfo @JingwenYang_ @yingjing06 @GreenLymphoLab @_meimeimei_ @MDAndersonNews that adds much to my recent review of this exciting field https://t.co/2m7WF34Pj3https://t.co/OwZDZa1vCk
2023-02-07 02:47:00 RT @danielalamasmd: Imagine if your life expectancy increased by decades within your own lifespan. That’s the story for cystic fibrosis rig…
2023-02-07 02:27:25 RT @DanielCohrsMD: Great article + thread on #LongCovid and the innovative review paper below, written as a collaboration between patients…
2023-02-07 00:20:26 We had the real privilege of having @pearsekeane, @ucl Prof of Artificial Medical Intelligence, as our @ScrippsRTI visiting professor today https://t.co/odHJlYLIBx
2023-02-07 00:03:57 Vitamin D may reduce the risk of developing Type 2 diabetes in people deemed pre-diabetic, combining 3 randomized, placebo-controlled trials with a modest effect https://t.co/3hYOVKUQWH @AnnalsofIM https://t.co/opbeuZcx2L
2023-02-06 23:50:47 RT @VirusesImmunity: A team member working on our #PrimeandSpike nasal spray COVID booster vaccine developed #longCOVID Long COVID is a…
2023-02-06 18:48:58 More on this report linking the APOE gene with gut microbiome-brain communication https://t.co/hkWNHdTmck @Nature @Alfonso_525 @UFNeuroscience @UFMBI https://t.co/zvNyxYhez0
2023-02-06 17:23:02 RT @WesElyMD: 25/ fin Read the most well-researched review on Long COVID to date @ahandvanish &
2023-02-06 16:26:11 Based on nationwide screening in Iceland, the prevalence of smoldering multiple myeloma (precursor to MM, no symptoms) is higher than expected and has implications for early treatment https://t.co/ozVoIhzqj2 @NatureMedicine https://t.co/tqBRuHS2LX
2023-02-06 16:18:54 A study today purports a healthy lifestyle before Covid was associated with reduced risk of #LongCovid. That doesn't align with my experience at all—that affected individuals were remarkably health conscious and fit https://t.co/zYAnqeihUu @JAMAInternalMed https://t.co/IY1H9Fprs9
2023-02-06 16:08:56 Excess mortality among American physicians during the Covid pandemic https://t.co/fGHu44FE9R "Active physicians had lower excess mortality than nonactive physicians despite their higher risk " @JAMAInternalMed https://t.co/gMEhQ2ibRc
2023-02-05 19:21:17 RT @euanashley: A landmark study. Adverse drug outcomes significantly lower in those with pharmacogenomically-guided therapy. It is time…
2023-02-05 17:24:07 Good graphic and essay for delineating the mechanism of tirzepatide (Mounjaro), a potent anti-obesity drug "that rivals the efficacy of bariatric surgery" https://t.co/A0WNI0yR62 @jclinicalinvest An important topic that I recently reviewed https://t.co/SMZO20WGRshttps://t.co/ouLG6obbgI
2023-02-04 17:51:45 Rare genetic disorders in the interferon pathway and life-threatening Covid https://t.co/Mn2XZ8Bjnb @jclinicalinvest by @casanova_lab and @MAndersonUCSF https://t.co/wjZIVTzBo3
2023-02-04 17:13:08 Two studies from leading labs characterized XBB.1.5 this week. We're very fortunate that the rise of this variant to dominance in the US was not accompanied by worse outcomes https://t.co/4y0WxqCzbe @SystemsVirology https://t.co/BcoiR7MItP @yunlong_cao @TheLancetInfDis https://t.co/ztUMayhP6w
2023-02-04 16:58:31 How can #AI help improve outcomes for lung cancer, the leading cause of cancer mortality worldwide? An outstanding review https://t.co/lSRW7kUDgU @CellRepMed @ColtonLadbury @DrAryaAmini @DrRaviSalgia @cityofhope https://t.co/wS7n8XWblH
2023-02-03 23:27:55 RT @inthebubblepod: What chronic symptoms and health risks are most common in those with #LongCovid ? @EricTopol tells @ASlavitt they can r…
2023-02-03 16:51:47 Insightful on #ChatGPT, LLMs for science "Soon this technology will evolve to the point that it can design experiments, write and complete manuscripts, conduct peer review and support editorial decisions to accept or reject manuscripts." https://t.co/u1Gj9Ln1h3 @Nature https://t.co/ZZJzCS7aNO
2023-02-03 15:53:53 The XBB.1.5 variant now accounts for ~66% of new cases in the US, up only ~5% from last week. https://t.co/jjl2AnOYb5 CH.1.1 still low at 1.6%. No other variants gaining at an appreciable level https://t.co/PfgVZMv7xj
2023-02-03 15:46:58 My conversation with @ASlavitt on #LongCovid and getting ahead of the virus https://t.co/tuQh6rktOj @inthebubblepod Regarding our recent review https://t.co/EgO7gtFvoe @ahandvanish @LisaAMcCorkell @julialmv @NatureRevMicro
2023-02-03 14:35:32 New and succinct review of postural orthostatic tachycardia syndrome (POTS) and autonomic dysfunction post-acute Covid https://t.co/Y6NHGkKTHV #LongCovid @ArturFedorowski @NatRevCardiol https://t.co/oEOGU4EmQV
2023-02-02 23:57:02 Dignity-based medicine "Respecting the dignity of the patient as a knower suggests that expertise should also include the expertise of patients—on their body, their experience of pain or joy, and how they weight the risk of harm against benefit" https://t.co/UgyNum3j5qhttps://t.co/PDwoBMw6wR
2023-02-02 23:20:24 The promise for T-cell therapies has jumped from their success in refractory blood cancers to approaching solid tumors, autoimmune conditions, and anti-scarring, along with many new ways to engineer the cells https://t.co/2m7WF34Pj3https://t.co/NX6vPfmJ18
2023-02-02 15:13:52 @PeacockFlu @LongDesertTrain Right, thanks to Ryan. And your new report culminating in this https://t.co/RzxY7Xdv92
2023-02-02 04:05:22 RT @EricTopol: The future of Covid vaccines that we need now, a new feature @Nature by @ewencallaway, including nasal, for mucosal immunity…
2023-02-01 20:51:49 RT @ScrippsRTI: Immunocompromised people are increasingly on their own when it comes to protecting themselves against COVID-19. @EricTopol…
2023-02-01 19:56:16 Ready for a smart toilet? https://t.co/agsdJb2kqx @ScienceTM I'm not. But it could be a good research tool for data collection for willing participants https://t.co/zkyfxJMbLw
2023-02-01 18:07:26 This was the "Dream Vaccine" exceptional @Sciencemagazine article by @sciencecohen nearly 2 years ago. Next generation vaccines are not a dream—they could have been a reality by now https://t.co/K7D2L3hNbYhttps://t.co/2btmXVGFZr
2023-02-01 17:59:06 RT @WHCOS: As COVID cases rose in Dec/Jan, ICUs were not crushed this time? Why? The world-leading @WHCOVIDResponse plan to make paxlovid…
2023-02-01 17:28:14 See @loganawalsh's explainer thread and congratulation to this @mcgillu team for both seminal papers! https://t.co/52549BKbwc
2023-02-01 17:24:48 One of the hottest fields is biomedicine is spatial resolution of #cancer via millions of single-cell mapping + #AI. Elucidating pathobiology and better ways to Rx 2 papers @Nature today on the brain and lung https://t.co/NfCCORa0akhttps://t.co/tfQqaeMPY5https://t.co/SSZ0J8bddm
2023-02-01 15:20:35 RT @Medscape: .@EricTopol and @cuttingforstone chat with the UK's professor @FryRsquared about taking risks and asking the right questions.…
2023-02-01 14:43:20 For nasal vaccines we got the first results from a large, randomized trial yesterday which were encouraging for inducing better immunity and less side-effects vs shots https://t.co/ufxF2r04wQhttps://t.co/P28GNuXW0G
2023-02-01 14:27:55 The future of Covid vaccines that we need now, a new feature @Nature by @ewencallaway, including nasal, for mucosal immunity, and universal, more durable, variant-proof ones with less side effects https://t.co/9U5xO2Ve1Bhttps://t.co/Mb8mHtDSVW
2023-02-01 00:55:58 RT @EricTopol: The 1st results for the @BharatBiotech nasal vaccine (BBV154, approved in India) randomized trial vs shots now posted, super…
2023-01-31 19:19:53 A good diagram by @daniella_raz @TheEconomist Example: —95% of Americans age 65+ have had at least 2-shots —Most Covid deaths are in people age 65+ who are vaccinated —There's still ~90% reduction of death for vaccinated vs unvaccinated https://t.co/oq3jBYkNly
2023-01-31 18:35:29 2. Pharmacists unwilling to prescribe Paxlovid, even though empowered (these are results from new @Medscape survey) 3. Dr. Jha is a champion for developing nasal and universal coronavirus vaccines and explains why it hasn't happened (yet)
2023-01-31 18:35:28 My interview with @AshishKJha46, leader of the @WHCOVIDResponse, about the pandemic We covered many important issues https://t.co/dzSNMOCQRH 1. Underuse of Paxlovid in older patients: not backed up by low incidence of rebound and ease of sidestepping potential drug interactions
2023-01-31 17:53:18 RT @JamesSurowiecki: An effective nasal vaccine for Covid would be exceptionally valuable.
2023-01-31 17:08:27 @AstroKatie @BharatBiotech There are no head-to-head trials of mRNA vs Covaxin so hard to know, different populations and tracking of outcomes. Data posted is for immune response and side effects only
2023-01-31 17:01:38 T and B cell responses for nasal vaccine (2 doses) vs Covaxin shots (2 doses) https://t.co/NBQ84Fgs2Y
2023-01-31 16:58:18 The 1st results for the @BharatBiotech nasal vaccine (BBV154, approved in India) randomized trial vs shots now posted, superior antibody and cellular immune response (vs ancestral and Omicron)
2023-01-31 16:31:05 The CDC quietly posts these data on their website (Jan 25th latest installment) which counters the myth that only people age 65+ derive survival benefit from boosters. There is nothing magical about a particular age cutoff-—it's a subgroup analysis used to support one's beliefs
2023-01-31 16:24:58 The #AI machine vision kicks in for the gastroenterologist late in the day when fatigue sets in: nearly 4-fold better performance for polyp detection in randomized trials https://t.co/eb1jhDkZMA @JAMANetworkOpen https://t.co/HNGm2Tfq2D
2023-01-31 16:00:12 The underused Covid treatment https://t.co/XcvEFol8A4 by @germanrlopez Significant reasons, as verified by the new @Medscape survey, are the exaggerated concerns about drug interactions and rebound not backed up by data
2023-01-31 15:00:05 More on the link between persistent infections and #LongCovid Among 381 infections lasting 30+ days, a 50% higher rate compared with infected controls https://t.co/MyUcgwIEvV
2023-01-31 13:59:46 Only high-income country without universal healthcare coverage https://t.co/Lmc6ULjHkZ
2023-01-31 13:59:41 The United States, the perennial outlier when it comes to healthcare spending and outcomes New data through 2021 vs peer countries by @commonwealthfnd https://t.co/qa9q75IEJB Worst @OECD life expectancy https://t.co/2tBkW9b7SH
2023-01-31 03:27:19 “I don’t think that the conventional cardiac surgeon, as we know him, will exist in a few years’ time” https://t.co/EkOEoBuczZ by @simonakam H/T @herbgreenberg https://t.co/A2AoWtcUYB
2023-01-30 23:28:38 Updated @CDCgov data on bivalent booster, age groups and deaths Overall 91% reduction of deaths across all age groups vs unvaccinated, less (80%) without bivalent booster The absolute reduction increases w/ age
2023-01-30 18:49:41 Innovation in cancer vaccines to markedly increase cancer antigen-specific T cells and activation of these cells @natBME @CHADNANO @DrMTeplensky @MirkinGroupNU @NUFeinbergMed @IINanoNU https://t.co/rLXCM7OI4rhttps://t.co/HEFCqldgqd
2023-01-30 18:17:49 RT @mehdirhasan: It’s mild! It’s like the flu! It doesn’t affect kids!
2023-01-30 16:40:15 New support for autoimmunity as a component for triggering atherosclerosis via CD4+ T cells https://t.co/d5EI71E8gV @mariedepuydt @UniLeidenNews https://t.co/LpjCBSMoNV
2023-01-30 16:10:37 From an analysis of 42 studies in 15 countries, "students lost out on about 35% of a normal school year's worth of learning" during the Covid pandemic https://t.co/yYm4nLNTob @NatureHumBehav https://t.co/iUMwWDjDEY
2023-01-30 16:03:45 "In this study, COVID-19 was a leading cause of death among individuals aged 0 to 19 years in the US." @JAMANetworkOpen https://t.co/AWawqJ0KLl by @flaxter and colleagues https://t.co/BIokfnMDez
2023-01-30 15:06:07 @hholdenthorp @DukeMedSchool @DavidJSkorton @AAMCtoday @Bob_Wachter It’s amazing it took this long for med schools and universities to stand up
2023-01-30 14:33:37 Some years ago, owing to the formidable and practical challenges, I thought the chance for T cell therapy to make a difference would be minimal. That's changing. https://t.co/2m7WF34Pj3
2023-01-30 01:00:00 CAFIAC FIX
2023-01-17 00:05:50 Mapping XBB.1's antigenic distance (among others): "We observed that human post-vaccination neutralisation titres reflected the antigenic map, as the largest reduction in neutralising titres compared with the D614G variant" https://t.co/epa5txNqqw @LancetMicrobe @bart_haagmans https://t.co/oEIeUKt8HR
2023-01-16 21:20:11 "I would advocate *not* moving fast and breaking things." —@demishassabis https://t.co/lvGrs8mwVl @TIME @billyperrigo on LLMs
2023-01-16 20:35:54 Important work andby @SystemsVirology to characterize the XBB.1.5 variant. Fortunately, our immunity wall in the US is helping to blunt its impact to be much less than Omicron BA.1. Could be even less w/uptake of bivalent vaccines and mitigation https://t.co/mnaA3kemLphttps://t.co/XRU6WCgsiW
2023-01-16 18:40:43 RT @VirusesImmunity: Amazing, timely, comprehensive, and evidence-based review - Long COVID: major findings, mechanisms and recommendations…
2023-01-16 17:33:35 We keep ignoring somatic mutations in the blood (CHIP) as an important risk factor for atherosclerotic cardiovascular disease, cancer, and all-cause mortality. Now a mechanistic underpinning: TP53, damage repair genes, unraveled @NatureCVR https://t.co/XttD6KynW4https://t.co/5Oh5WUMCN6
2023-01-16 17:18:09 @terrigriffith @SFUBeedie That was the intent. Many thanks!
2023-01-16 17:13:38 Just published @NatureMedicine An astute take on the future of clinical trials and evidence-based medicine, in the digital and #AI era, by @VivekSubbiah https://t.co/625WIwa6Qxhttps://t.co/cLpfZKAiMI
2023-01-16 15:53:04 I review the transformative potential of #AI in medicine, now in the era of LLM/Foundation Models, in this new post, with the links to the above exams and much more https://t.co/2Axg5C4HtT
2023-01-16 15:53:03 3. US, 2022, the large language model (LLM) Med-PaLM takes the US medical licensing exam. A huge (33% relative) jump in accuracy of answering medical questions: 92.6% doctors say the AI was correct vs 92.9% other doctors were correct. Now replicated by ChatGPT. https://t.co/16itDiq3LF
2023-01-16 15:53:02 The #AI takes the medicine qualifying exam. Three to take note: 1. China, 2017, Xiaoyi passed the licensing exam with a score of 456 (passing 360-600) based on memorization and information recall, with poor performance on patient cases https://t.co/Aq3fuDiOBP
2023-01-16 14:38:38 For more on pacing (top row of the Table), a very good piece by @AmandaMoMorris today @PostHealthSci https://t.co/jTE6rmXF6p
2023-01-16 01:50:44 @Mon4Kooyong Thanks and agree on the sure fire way to prevent #LongCovid
2023-01-15 19:44:42 You've been hearing a lot about ChatGPT, DALL-E, Stable Diffusion and other foundation #AI models (also known as Large Language Models or Generative AI) lately. How are they beginning to impact medicine and healthcare? https://t.co/2Axg5C4HtT
2023-01-15 18:36:02 Sorry, I gave the wrong twitter handle for my @ScrippsRTI colleague, @julialmv. That gives me a chance to note she is currently leading this important research project to help immunocompromised individuals https://t.co/cJb7tBzJGs
2023-01-15 18:30:31 Foundation #AI goes to the movies "A.I. could create in minutes what a filmmaker worked on for years" https://t.co/Af4aU6MOg9 by @frankpavich https://t.co/ISUVLIgw7U
2023-01-15 00:58:46 RT @doctorasadkhan: This is THE #LongCovid paper. Comprehensive yet accessible, jam packed with everything you need to know. Science 1-psyc…
2023-01-14 22:58:51 An excellent review of the challenges surrounding highly effective and durable nasal vaccines to achieve mucosal immunity vs respiratory viruses (including #SARSCoV2) https://t.co/TCQKwpCYKO by @NIAIDNews @cellhostmicrobe H/T @mtosterholm https://t.co/0iY0ec2HJA
2023-01-14 17:34:18 The ~80% bivalent booster vaccine effectiveness (US and Israel studies) summarized is compared to controls with prior infections, vaccinations and boosters, making that high level of protection for people age 65+ noteworthy
2023-01-14 17:30:39 The US did a great job getting its seniors vaccinated, with 94% having the primary series of 2 shots. But in the last 6 months, less than 40% have gotten a booster, and they account for most of the hospitalizations and deaths https://t.co/tR5S4BBaYb
2023-01-14 17:03:23 "These exciting results highlight the potential to harness the gut microbiota to prevent or slow the progression of AD and other tauopathies and raise awareness about the potential long-term effects of early-life diet" https://t.co/c4Xh83gekQ @Tan_ee_Ya @YuemingLiLab https://t.co/lLz2meYgR0
2023-01-14 15:00:15 RT @ahandvanish: Our review of #LongCovid research is out! This was a HUGE labor of love over 10 months from @julialmv @LisaAMcCorkell @Er…
2023-01-14 14:17:13 @zalaly @ahandvanish @LisaAMcCorkell @julialmv @NatureRevMicro Thanks Ziyad! Much of what we know about #LongCovid comes from your outstanding research contributions
2023-01-13 23:39:12 RT @loscharlos: Absolutely incredible work — a comprehensive overview on the explicit biological abnormalities of #LongCovid — thank you @E…
2023-01-13 23:39:06 RT @DrCaliff_FDA: The bivalent COVID-19 vaccines have been associated with a significant reduction in hospitalization and death in all popu…
2023-01-13 22:06:22 @nickiykwim @ahandvanish @LisaAMcCorkell @juliamv @NatureRevMicro Thanks for noting this Correct link @julialmv
2023-01-13 20:48:36 This was an outgrowth of a very long process, with multiple rounds of peer and editor reviews. In a field constantly updating. But it was all worth it to have the privilege to work with 3 all-star co-authors, each of whom have had #LongCovid. We hope you'll find it useful
2023-01-13 20:29:26 I amended my extensive review of the bivalent booster this week, which works better than expected, to comment on this issue https://t.co/tR5S4BBaYb
2023-01-13 20:29:25 Today the CDC reported a possible safety concern about the Pfizer bivalent vaccine, unconfirmed by any other dataset https://t.co/on5LcVmNwz @lauriemcginley2 @bylenasun https://t.co/Fwqg7YLpFn
2023-01-12 23:35:12 A couple of corrections to the Table, thanks to @BarouchLab —Moderna used a pseudovirus assay —The Suthar (Emory) study changed from 4-fold (bivalent vs original) to 2.3-fold vs BA.5 from their preprint to the @NEJM report https://t.co/cHyo16WjSE
2023-01-12 21:15:36 "These findings highlight the key role of antigen presentation at the mucosa and support a protective effect of mucosal immunity for up to 8 months" https://t.co/zUuVnRamin What nasal vaccines could simulate to achieve durable mucosal immunity https://t.co/lZv2BqyXh4
2023-01-12 19:29:28 RT @GeoffreySupran: NEW: In @ScienceMagazine today, our latest peer-reviewed research shows Exxon scientists predicted global warming with…
2023-01-12 17:27:15 For decades the #AI field has loosely used the term artificial neurons. Now they've really been made https://t.co/qpinCVNyEk artificial neurons that closely mimic the characteristics of biological nerve cells @NatureMaterials
2023-01-12 16:56:27 Good news: In the Northeast where the XBB.1.5 variant now accounts for >
2023-01-12 15:51:27 RT @NightShiftMD: Read the fantastic review by @EricTopol. The bivalent booster dramatically prevents hosp and death esp in older patients…
2023-01-12 13:58:36 RT @Bob_Wachter: Important thread: @EricTopol was a bit skeptical about the bivalent when it rolled out. His detailed review of emerging la…
2023-01-12 02:13:26 I was quite skeptical in September when the bivalent was rolled out without human data. Now there’s compelling evidence to support its benefit.
2023-01-11 23:40:11 3. The vaccinated individuals did better: less dyspnea and more likeness to controls. 4. Children had more Strep throat &
2023-01-11 23:40:10 2. Major symptoms of difficulty breathing, cognitive impairment and weakness were present at 1 year. Also loss of smell, taste, dizziness and cough https://t.co/bF6hIauesm
2023-01-11 23:40:09 A new retrospective nationwide EHR assessment of #LongCovid in ~230,000 people w/ mild Covid and matched controls for age, sex, vaccination status, variant Some downplaying of persistent symptoms at 1 year: 1. Median age of cohort = 25 years. People age 41-60 had worse outcomes https://t.co/BV5qyoxQHU
2023-01-11 22:00:50 The Covid bivalent vaccine booster works better than expected. I've reviewed the cumulative data https://t.co/tR5S4BBaYb That's in contrast to a @NEJM essay today and 2 lab studies that used a pseudovirus assay without assessing the XBB variants
2023-01-11 19:58:14 Cell-free DNA fragmentation patterns and sequencing from small amounts of plasma hold considerable promise for screening and early detection of cancer https://t.co/9FRzcWj9Pj @ScienceTM https://t.co/ui6GlTSzyg
2023-01-11 19:05:38 Some #SARSCoV2 mutations that confer resistance to Paxlovid have been deposited @NCBI &
2023-01-11 18:28:23 Immune evasion of #SARSCoV2 typically refers to our antibodies having less neutralization capacity vs new variants. But our 1st line of defense, the innate immune system—interferons—also play a critical role as elegantly reviewed https://t.co/eCw4D5BslI @JudyMinkoff @virusninja https://t.co/jC64iN7Hx5
2023-01-11 18:01:02 @AshishKJha46 Referring to this brief thread post https://t.co/3LZnn5o3SU
2023-01-11 18:00:06 The Table accompanying this post was inadvertently deleted https://t.co/DMZlKiW4PZ
2023-01-11 17:54:53 RT @AshishKJha46: Dr. Topol is right. The evidence from high quality studies is clear: The bivalent vaccine is far superior to the origi…
2023-01-11 16:58:02 RT @WesElyMD: “China’s in the midst of a #Covid crisis w unmitigated spread &
2023-01-11 04:03:40 An outstanding appraisal of #SARSCoV2 evolution as an antigen, the potential role of immune imprinting (original antigenic sin), and strategies to prevail https://t.co/OJGA1RA4kn @jclinicalinvest @MarionKoopmans @GijsbertNierop https://t.co/LaZvpQqXNZ
2023-01-10 20:54:27 While the bivalent booster was directed against BA.5, fortunately it broadens immunity and works better than the original booster for inducing antibodies vs BQ.1.1 and the XBB variants. Live virus assays are more reliable than pseudovirus
2023-01-10 20:44:17 Summary of the 8 lab studies for the bivalent BA.5 vaccine booster vs original. Neutralizing antibody (nAb) levels vs BA.5 and XBB variants All 5 live virus studies showed significant increase (3-8 fold) nAb increase for bivalent vs BA.5 and some cross-immunity vs XBB https://t.co/r4UuBdobhE
2023-01-10 17:57:36 "These data demonstrate that MVA-S vaccination confers a complete protection against #SARSCoV2 brain infection and the associated neuropathological damage (neuronal loss and vascular damage), even after a second viral infection." https://t.co/rHzB2Yu4hD @NatureNeuro @ibis_sevilla https://t.co/rzGOTPkeAe
2023-01-10 16:59:16 Bacteria play a more significant role in cancer than we previously envisioned, as we've recently been learning via spatial genomics https://t.co/E0tvczq68A @ImmunityCP @natedandy_PhD @sangerinstitute https://t.co/mi9MqNbxc3
2023-01-10 14:32:06 "The bivalent booster vaccination enhanced neutralizing antibody titers against all Omicron lineage viruses tested, including a 10-fold increase in neutralization of BQ.1 and BQ.1.1 viruses that predominated in the US." https://t.co/MbyhV05r9j
2023-01-10 14:15:03 “It’s almost certainly going to dominate in the world. I cannot find a single competitor now. Everything else is incomparable.”—@yunlong_cao https://t.co/bo13QV7xVo
2023-01-09 22:16:05 Let's create some proteins [Stop dilly-DALL-E-ing with silly images] Potential for foundation #AI models to impact life science https://t.co/kbqTbzDWzn @CadeMetz https://t.co/4C7Pa6kF9n
2023-01-09 16:25:18 The association of healthy heating habits and reduced mortality in 2 large cohorts, ~120,0000 people, with up to 36 years follow up. across all racial and ethnic groups https://t.co/qcpcuCdxzX @JAMAInternalMed with the usual diet study caveats @HarvardChanSPH https://t.co/MZ8nCJfyBX
2023-01-09 00:49:15 “The implications of XBB.1.5 are also much bigger than just this formidable variant. The virus is talking to us, and it is telling us it has many more ways to evolve.”
2023-01-09 00:25:52 “That [XBB.1.5] should serve as a wake-up call for the country to re-invest in new vaccines, treatments and pandemic monitoring”
2023-01-08 03:31:52 RT @HamlinIsland: Putting love into the world comes back 3xs as much… thankful for everyone who has reached out and prayed. This will make…
2023-01-07 22:37:46 The poor pharma industry https://t.co/oZ7fhX3D9i by @david_wainer "It’s in the industry’s best interest to say the sky is falling”—@DusetzinaS https://t.co/3g0cdrdiXo
2023-01-07 19:30:37 There are important differences between multisystem inflammatory syndrome in children (MIS-C) vs Kawasaki's disease, but still much to learn about its pathophysiology https://t.co/TIg9U0knK0https://t.co/j3YU5eq78f
2023-01-07 19:02:39 @RickABright @GISAID Community extrapolation only, unfortunately
2023-01-07 18:50:36 But in North Carolina, with much lower % XBB.1.5, a similar spike in hospital admissions among seniors, which supports other factors besides this variant as a principal driver https://t.co/1nk28wAwHT
2023-01-07 18:50:35 The notable rise of Covid hospitalizations in the Northeast, where XBB.1.5 variant accounts for ~75% cases, among people age 70+, especially in Massachusetts (approaching ~80% of its BA.1 wave) https://t.co/OYKQV32gvzhttps://t.co/aVyTHlHXiQ
2023-01-06 22:06:50 RT @aetarke: Can CD4+ T cells cross-recognize different coronaviruses (CoV), offering immune protection from potential future CoV pandemics…
2023-01-06 19:24:21 You would think the @US_FDA would have learned from Aduhelm. This drug is not deserving of any accelerated approval https://t.co/AsbZSO0RhF
2023-01-06 17:23:27 New York, where the XBB.1.5 variant was first detected, and the US bellwether for its growth, still shows signs of increasing hospitalizations, particularly for those age 70+ https://t.co/3YFO480SJ6
2023-01-06 17:16:37 Northeast region dominance of XBB.1.5 unchanged, 5 of the 8 regions still in single digits https://t.co/013DOVZXwF
2023-01-06 17:16:36 New @CDCgov #SARSCoV2 variant report Corrects/ lowers XBB.1.5 proportion of new cases from ~40% (last week) to 28% nationally now, leaving more runway before this variant achieves dominance cross country. No other variant showing growth https://t.co/jjl2AnOYb5https://t.co/SGHJmQ12NH
2023-01-06 06:06:36 I’d reject their proposal for various reasons, but will let you and respondents air it out
2023-01-06 05:43:03 A new explanatory model proposed for #LongCovid https://t.co/62ztuTDsPH @LancetRespirMed "an embodied condition with heterogeneous biological, psychological (experiential), and social (or environmental) factors integrated in complex relationships" https://t.co/8ygX8cYeqc
2023-01-06 00:59:42 A new study finds no indication of autoantibodies, an intact immune response vs controls (antibody and T cell) but evidence of persistent, elevated circulating full-length spike protein unbound by antibodies https://t.co/mdYuj6x2Wwhttps://t.co/0OSC1NNg0g
2023-01-05 20:08:04 The essentiality of wastewater surveillance "Core component of infectious disease monitoring, providing a variant-specific, community-representative picture of public health trends that captures previously undetected spread and pathogen transmission links" https://t.co/D0D8WcP2bM
2023-01-05 19:57:47 How obesity can induce neuroinflammation: Reprogramming innate immunity, particularly macrophages (via epigenetics), can facilitate age-related macular degeneration in an experimental model https://t.co/Q1seFXIxwkhttps://t.co/JPEsOfWlSg @ScienceMagazine https://t.co/5jQMrO4hZ7
2023-01-05 17:39:35 "All around the world, Covid surveillance is faltering. That, rather than the surge of cases in China, is the main reason for worry" The number of sequences submitted @GISAID has dropped 90% https://t.co/noDmDB4bDZ
2023-01-05 00:58:42 RT @TWenseleers: @BrunnCarrigg @Tuliodna @EricTopol Also see graph below. There is some registration delays apparently... https://t.co/ECnM…
2023-01-05 00:58:33 RT @TWenseleers: @BrunnCarrigg @Tuliodna @EricTopol The effect, like for BQ.1, will be felt mainly by seniors (which is perhaps why Tulio t…
2023-01-04 23:07:45 From studying transmission of the Delta and Omicron variants in nearly 2000schools and 300 preschools in Australia: “community restrictions, rather than school closures, best mitigated COVID-19 impacts.” https://t.co/wOruadiPk8…
2023-01-04 19:17:36 @Tuliodna Dear Tulio, I don’t think it’s being overplayed due to its remarkable growth advantage and very rapid rise to dominance here and likely much of the world But I agree that our immunity wall will undoubtedly blunt its impact
2023-01-04 19:12:51 “Our results highlight the importance and feasibility of a universal vaccine to fight against SARS-CoV-2 antigenic drift.” @ScienceTM https://t.co/yrNkWjQwb2
2023-01-04 18:21:31 No, vaccines DO NOT induce variants. That's what infections do. Blatant misinformation: "Growing evidence also suggests that repeated vaccinations may make people more susceptible to XBB" https://t.co/JroxuQpxe8
2023-01-04 17:55:53 The #SARSCoV2has been relentlessly evolving over the past 3 years to find new hosts. Its latest iteration, XBB.1.5, acquired a critical double mutation that maintains high level of immune escape while increasing infectivity by @yunlong_cao and colleagues https://t.co/32QqpChRVRhttps://t.co/M2GxCbmcgs
2023-01-04 17:27:58 Science and technology are getting less disruptive on the basis of 45 million papers and 3.9 million patents published in the past 6 decades https://t.co/7RxiutNR9z @Nature @russellfunk @michae1park https://t.co/RHLYmJYQz6
2023-01-04 16:28:20 The @UF faculty report on Florida surgeon general Ladapo's "seriously flawed," "careless, irregular, or contentious [vaccine] research practices" https://t.co/W7JQsRUWlThttps://t.co/r2HxNltPve
2023-01-03 23:05:34 Why hasn't Paxlovid implementation lived up to its expectations? Prescribed for only 13% in the US &
2023-01-03 21:36:50 A hopeful turning point for Japan after having gone through its worst wave for fatalities https://t.co/ifrPlXXEdc
2023-01-03 21:19:07 @JohnKasich @vkhosla Meanwhile, for comic relief you can't beat @themattfriend https://t.co/RtXHTP5kYw
2023-01-03 16:53:30 @TWenseleers Much appreciated, Tom
2023-01-03 01:01:35 ~63% of Americans age 65+ have not had a recent/bivalent booster, leaving them vulnerable —Lab data supports some bivalent booster cross-immunity protection vs XBB.1.5, even though it was BA.5 directed —Before XBB.1.5 becomes dominant across the US, that's a way to help defend
2023-01-03 00:45:47 That's >
2023-01-03 00:43:38 I reviewed all we know about the XBB.1.5 variant 10 days ago, w/its high transmissibility https://t.co/mnaA3kemLp The ? now is whether it will have a material impact on adverse outcomes, for which there is some evidence among seniors in states with >
2023-01-02 19:55:06 Annual sales of tirzepatide (Mounjaro) may reach $48 billion, far surpassing prior records. I reviewed why these new obesity drugs are a breakthrough, but also a liability https://t.co/FUYOzzzm73https://t.co/SMZO20WGRs
2023-01-02 19:49:58 Unraveling #Alzheimer's disease by single-cell genomics, a new tour de force review https://t.co/Wihfht4gbe @NatureNeuro @mhmurdock1 @DrLiHueiTsai @MIT https://t.co/R0B7Jwa6WW
2023-01-02 17:31:06 Comparative effectiveness of Pfizer vs Moderna booster shot in US Delta and Omicron waves via large @DeptVetAffairs experience https://t.co/ecVit591vO Significant less symptomatic infections and hospitalizations among those treated with Moderna @NatureMicrobiol https://t.co/8lV7RpmRni
2023-01-02 17:11:42 New @NatureMedicine Proof that Covid vaccines do reduce Omicron transmission from prison data, but the impact is ~20-40% https://t.co/du9ABpahEq
2022-12-31 22:31:29 RT @BNOFeed: BREAKING: Number of Americans hospitalized with COVID-19 rises to 45,279, the highest since February
2022-12-31 22:29:13 RT @JPWeiland: I can confidently say XBB.1.5 will NOT approach the levels of hospitalizations and deaths seen in the initial Omicron wave i…
2022-12-31 18:33:05 Where were the major #SARSCoV2 variants that led to continental or global dominance first detected? Alpha—United Kingdom Beta—South Africa Gamma—South America Delta—India Omicron—Southern Africa XBB.1.5—United States
2022-12-31 18:19:50 “If you make a big bet, and you’re successful with a program [Operation Warp Speed], you should keep making big bets" https://t.co/zHVRYmP4vW @SmithsonianMag by @SimarSBajaj
2022-12-31 16:24:03 RT @Ideas_Sleep: 'The UK is incontrovertibly the world leader in genomics' – @EricTopol In 5-10 years, the UK looks set to lead the way i…
2022-12-30 21:13:00 RT @BNOFeed: Number of Americans hospitalized with COVID-19 rises to 44,138, the highest in more than 5 months
2022-12-30 20:00:31 New data for bivalent protection vs Covid hospitalization For age 65+, >
2022-12-30 17:34:58 Current US regional variant map. XBB.1.5 just getting started in multiple regions https://t.co/XM3fjdtoYB
2022-12-30 17:18:57 @JuliaRaifman Right, Julia. Unfortunately, That’s the XBB.1.5 signature seen in many Northeast WW in recent days
2022-12-30 17:16:26 All we know about the XBB.1.5 variant summarized here a week ago https://t.co/mnaA3kemLp We’ve not seen such rapid growth of a variant since Omicron BA.1 a year ago. Total US XBB last week = 18% of cases. Northeast now ~75% XBB.1.5. Perhaps CDC and media will finally take note
2022-12-30 17:05:15 Wow. XBB.1.5 more than doubled across the United States in 1 week, now ~40%, out-competing all variants https://t.co/PeE8P7eAeH
2022-12-30 16:14:48 @chrischirp Heading towards multi-continental dominance, first one USA evolved (first detected in New York)
2022-12-30 01:39:00 @ansonjtong You'll be hearing a lot more about it tomorrow (finally)
2022-12-30 01:38:24 Among the best @nytgraphics for 2022, this one for #LongCovid really stands out https://t.co/pYPLoTTQUj @joshkellerjosh
2022-12-29 19:50:11 "This is not how epidemiology works. One cannot extrapolate a death rate across a nation from a single death." —@kmpanthagani https://t.co/Le7cUb4nlIhttps://t.co/KQWzZkN4hY
2022-12-29 18:20:37 For people age 65+, the bivalent booster linked to >
2022-12-29 17:42:09 @jordan_peccia @kmpanthagani This is what XBB.1.5 looks like
2022-12-29 17:16:23 The predictive utility of a heart disease polygenic risk score for primary prevention, use of statins, especially in people less than age 50 https://t.co/hCMjfzTxgX @JAMACardio by @marstonMD and colleagues https://t.co/JmwBIKB4pu
2022-12-29 15:56:40 With focused on China, Japan, a country w/ one of the best pandemic outcomes, as previously reviewed: https://t.co/z68bDAQuhi is experiencing its worst death toll, during a 2nd BA.5 wave, with waning immunity, under-boosted, and 25% population age 65+ https://t.co/o7TgtHAgWn
2022-12-28 23:50:14 I asked why, with all the evidence, there is such resistance to accepting that masks help (for all respiratory viruses) https://t.co/rPJBJ0VjOh
2022-12-28 22:42:41 New @NEJM A randomized trial of an oral remdesivir analog drug (VV116) vs Paxlovid suggests it may provide an alternative (fulfilling the pre-specified non-inferiority criteria, but 1.17 hazard ratio) https://t.co/ytECEc0Fvbhttps://t.co/TmvZTCWDMe
2022-12-28 15:57:51 This is the summary of all @CDCgov and media coverage of the XBB.1.5 variant to date https://t.co/R5jKtidChB
2022-12-28 15:53:30 There are ~7 million Americans who are immunocompromised, more vulnerable to severe Covid, and now Evusheld rendered ineffective. We've just launched a new direct-to-participant-research program with free molecular tests &
2022-12-28 05:24:39 We’ve just launched a new research program for immuncompromised individuals in the US with free home molecular testing and rapid access to medications when needed. Please help spread the word https://t.co/PfZGBYjcQi
2022-12-28 02:22:28 I've updated this post on the XBB.1.5 variant with new data provided by @yunlong_cao, @JPWeiland and @rquiroga777. For those questioning what could be done if CDC/media raised awareness (for which there has been none), that is addressed, too. https://t.co/mnaA3kemLp
2022-12-28 01:53:57 @yunlong_cao @JPWeiland @LongDesertTrain Thanks Yunlong. That’s precisely the piece that was missing….that you’ve filled in once again
2022-12-28 01:13:39 @SystemsVirology @yunlong_cao @biorxivpreprint Thanks @SystemsVirology! Have you done any assays for XBB.1.5?
2022-12-27 23:19:45 RT @JPWeiland: I overlaid some of @trvrb group's analysis of effective Reproductive Number over time since a variant first starts spreading…
2022-12-27 19:43:01 A functional @CDCgov would alert the public about the XBB.1.5 variant—which has already established dominance throughout the Northeast—and, with its big growth advantage over BQ.1.1, soon country-wide. https://t.co/tL2Y2HF2ew
2022-12-27 00:38:23 The Outlier 2021 US health care expenditures: $4.3 trillion
2022-12-26 23:38:46 @rquiroga777 Thanks so much, Rodrigo. I think your graphic is the best way to simply and accurately represent the progression of mutations that led to XBB.1.5. I revised the Substack post to include it https://t.co/mnaA3kemLp
2022-12-24 21:48:54 RT @LongDesertTrain: Excellent piece by @EricTopol on XBB.1.5, which @JPWeiland first called attention to a couple weeks ago. Nothing is ce…
2022-12-24 19:56:55 @macroliter Agree. To be announced soon
2022-12-24 19:15:21 @Globalbiosec Thanks so much, Raina. Very kind of you! All the best for the holidays
2022-12-24 18:38:54 Highly recommended for straight talk about airborne transmission of respiratory viruses (including #SARSCoV2) and how we can defend against it
2022-12-24 18:11:23 I've added citations to @jbloom_lab @LongDesertTrain @RajlabN. All indications are that XBB.1.5 will become dominant throughout the US in the weeks ahead, the 1st variant evolved here to have such marked growth advantage.
2022-12-23 22:48:03 Special thanks to the people who have been carefully tracking the variants, whose work is referenced in this post @yunlong_cao @JPWeiland @dfocosi @rquiroga777 @PeacockFlu @CorneliusRoemer @richardneher @siamosolocani @firefoxx66 https://t.co/pHj2uAkZiI @nextstrain
2022-12-23 20:31:57 @NoAutocracy Appreciate your feedback
2022-12-23 19:50:30 I wrote about the XBB.1.5 variant in the United States https://t.co/mnaA3kvpNp
2022-12-23 18:34:35 During surgery, frozen sections of tissue are obtained for key decision making (e.g. resecting a tumor) but there are problems w/ speed &
2022-12-23 18:23:31 "Our study demonstrates that [Molnupiravir] this commonly used antiviral can supercharge viral evolution in immunocompromised patients, potentially generating new variants and prolonging the pandemic." https://t.co/dRr0ifMF6t
2022-12-23 17:29:40 The good news is that the US flu season has peaked, started descent https://t.co/GoRVfCcLvn
2022-12-23 15:32:39 New York is the XBB.1.5 bellwether A brief thread on what's going on there and this variant https://t.co/B9hkn2MeeB
2022-12-23 15:30:20 New US #SARSCoV2 genomics indicates an important shift to XBB gaining on BQ.1.1. While the BQ.1s are dominant overall, the Northeast is now XBB dominant (particularly rapidly growing XBB.1.5) https://t.co/jjl2AnwOWXhttps://t.co/0wSbgRjtTK
2022-12-23 04:13:13 The 2 key mutations beyond XBB that appear to be linked to XBB.1.5's big growth advantage https://t.co/a1SGsKkRqr
2022-12-23 03:20:29 What variant has the highest growth advantage of all in the mix right now https://t.co/PInFKwKIlz XBB.1.5 (based on a large number of sequences) https://t.co/ELJyQTlMlR
2022-12-23 02:07:28 If you like impersonators, Matt Friend is amazing His range seems limitless and he moves from one character to another like I've not seen before (maybe Robin Williams). https://t.co/nB91MxXL4t
2022-12-23 00:38:00 RT @linseymarr: What a delight to chat with @EricTopol for a @Medscape podcast about virus transmission and interventions!
2022-12-23 00:21:55 While the time to recovery was shortened, the price to pay is a very high rate of #SARSCoV2 mutations induced (its obligatory mechanism). That alarming rate has been amply documented by @LongDesertTrain https://t.co/RIPTr3useXhttps://t.co/ignWWSTU9B
2022-12-22 23:30:00 Just out @TheLancet Failure of Molnupiravir to reduce Covid hospitalizations or deaths in a very large randomized trial (N>
2022-12-22 21:42:17 Highest Covid hospitalizations in New York since January and soaring in seniors, as the XBB variant with added mutations gains growth advantage https://t.co/cz0BwwaIM3https://t.co/AE7Gh7fQ1P
2022-12-22 20:04:00 My conversation this week with Prof @linseymarr, a civil engineer and leading authority on air quality, viruses, and the impact of masks. She's a remarkable explainer and my go-to expert on this topic https://t.co/cX7MPqhVjE #COVIDIsAirborne @Medscape
2022-12-22 19:16:03 Late after mRNA Covid vaccines, or with booster or breakthrough infections, there is a shift to IgG4 antibodies, not seen with adenovirus vector vaccines. The clinical significance is not known https://t.co/5thLxRwemm @SciImmunology @UniFAU https://t.co/YozSLVjVLd
2022-12-22 18:38:38 Another death in the lecanemab trial https://t.co/yX1xWdZ1TM @ScienceMagazine @cpiller
2022-12-22 17:58:15 RT @erikbryn: The news about life expectancy in America is devastating. Covid is taking a huge toll, but so are other causes like drug over…
2022-12-22 17:42:16 "We discovered large-scale mother-to-infant interspecies transfer of mobile genetic elements, frequently involving genes associated with diet-related adaptations." https://t.co/36B9VDy6QN by @tvatanen and colleagues @broadinstitute https://t.co/3aoXtFImGX
2022-12-22 16:57:02 BTW the cover of @CellCellPress this week shows #3D the aortic regions of a human heart whose vascular plaques are analyzed by DISCO-MS (#AI) technology (1st post in this thread) https://t.co/9n0KNUtS1T
2022-12-22 16:51:01 More jumps in the era of spatial omics 3D proteomics of intact tissue with #AI https://t.co/R7rhPr8jAj @CellCellPress @erturklab @labs_mann
2022-12-22 15:17:24 Now at a 25 year low, life expectancy in the US continues to fall. Covid persists as the 3rd leading cause of death and increasing ~20% over 2020 https://t.co/KldEystLDM @littlewern @jon_kamp https://t.co/hWpAGoQ49g
2022-12-22 01:21:01 @emollick Agree!
2022-12-21 23:53:08 When the #AI couldn't pass the radiologist qualifying examination @BMJ_latest (with special dispensation) @SusieShels @JWeirMcCall and colleagues https://t.co/CRGgMzdCTMhttps://t.co/m3aoYeAGZi
2022-12-21 22:59:26 Full text. One of multiple lab studies now to show the bivalent booster helps increase the immune (neutralizing antibody) response vs BQ.1.1 and XBB https://t.co/dejyM7rNrb
2022-12-21 22:01:00 New @NEJM "Persons who received the BA.5-containing bivalent booster had better neutralizing activity against all Omicron subvariants (especially against BA.2.75.2, BQ.1.1 and XBB) than those who received 1 or 2 monovalent [original] boosters" https://t.co/5m6Pmahli3https://t.co/zuiyGWmAfC
2022-12-21 19:18:05 A step towards improving potency of immune response for RSV vaccines. Stabilizing the pre-fusion conformation, as used in many Covid vaccines @ScienceTM https://t.co/CxDiDh0j24 @RuckwardtTracy @lauren_a_chang @NIAIDNews https://t.co/eWzSsA9DTohttps://t.co/ayEPSvIUqh
2022-12-21 19:00:03 Why do some people have persistent loss of smell post-Covid? A biopsy-based study shows durable T-cell mediated inflammation long after the virus is cleared from tissue @ScienceTM by @goldstein_brad and colleagues https://t.co/5iG5ZaCtTXhttps://t.co/u56zCWlIGF
2022-12-21 16:13:28 New @Nature A significant discovery underpinning glioblastoma, a deadly brain cancer, involving an epigenetic target (BRD8) that blocks P53's guardian function https://t.co/N9rVOz9WkR by @CSHL @SunSherine @olaf_klingbeil and colleagues https://t.co/sEeQJZNOF3
2022-12-21 01:51:34 RT @elonmusk: I will resign as CEO as soon as I find someone foolish enough to take the job! After that, I will just run the software &
2022-12-20 23:47:39 The Framingham Risk Score for heart disease originated 25 years ago. Today @TheLancet a new holistic score/model was tested and validated in 2 large biobanks https://t.co/Bs1lnkrnTE @DoGenetics @IainSForrest @IcahnMountSinai @OmegaPetrazzini #AI https://t.co/ya5HqCP2Bg
2022-12-20 23:23:09 Repeated exposures to Covid or vaccines have little impact on spike-specific T cells in the circulation, in contrast to antibodies https://t.co/VYo9oo5m5h (does not address T cell breadth, homing, or durability) by @virusmonologues and colleagues @UCT_news https://t.co/W30IcpHUZF
2022-12-20 19:35:21 RT @p_openshaw: Thanks @EricTopol for flagging our study- big collaborative effort by @CCPUKstudy and especially @FelicityLiew ,@InThwaiteI…
2022-12-20 17:11:25 A good sign. France, the 1st country to face the BQ.1.1 variant dominance, and the US, were running neck and neck for Covid hospital admissions. Now they're diverging and France is in descent for cases. @OurWorldInData https://t.co/Gl7UoLZ6AX
2022-12-20 16:53:34 We keep evolving.... "A more expansive view of the functional potential of the human genome... embraces these hard-to-detect, small, but significant proteins that show no traces of conservation." https://t.co/SBgKjQZlsQ @CellReports https://t.co/79md3Qm4bo
2022-12-20 16:47:58 @T_Brautigan @eBioMedicine @FelicityLiew @ShubhaTalwar Maybe you should read about it, like the piece I wrote with @VirusesImmunity @SciImmunology, before sending DON'T replies. #SARSCoV2 ≠ flu. https://t.co/OujfFxMgU6https://t.co/KdVRVVp5fM
2022-12-20 16:25:13 We just learned a lot more on the genomics of colon cancer. A multi-omics approach in over 100,000 cases shows association cumulatively up to 73% of familial risk @NatureGenet @fredhutch and global collaborators https://t.co/mguJS3KpAjhttps://t.co/KxwMkFL8nU
2022-12-20 15:29:01 New @ScienceMagazine Following Covid, MIS-C, the rare and potentially lethal multisystem inflammatory syndrome in children, has been elusive for its biologic basis. Today a report of 5 unrelated kids with genetic OAS-RNase L deficiencies https://t.co/LHgIlLeMIS Link needs fixing https://t.co/V1CguLr844
2022-12-20 15:07:06 RT @ScienceMagazine: The authors of “Gradual emergence followed by exponential spread of the SARS-CoV-2 Omicron variant in Africa” are retr…
2022-12-20 01:26:34 Why we desperately need nasal vaccines to block infections and reinfections https://t.co/hzYDvrq34M @eBioMedicine by @FelicityLiew @ShubhaTalwar and colleagues https://t.co/G3nJiGwiSz
2022-12-19 20:22:34 RT @kmpanthagani: You may have heard the shocking headline that 250,000 people die every year in the US due to misdiagnosis in the ER. You…
2022-12-19 17:10:59 Rapid sequencing of blood or relevant body fluids can identify the root cause of serious infections and help guide therapy (in less than 8 hours), but, with rare exceptions, it isn't being done. Now ~9 years after proof of its lifesaving capacity https://t.co/Hr6AVrNBRBhttps://t.co/Sy8UUXWIQo
2022-12-19 16:51:05 The tonsils and adenoids of children who have had Covid have persistent tissue-specific immunity which includes antigen-specific memory B and T cells https://t.co/fxTpLKz1oU @NatImmunol by @ManthiramMD and colleagues @NIAIDNews https://t.co/dkxB458zgt
2022-12-19 16:31:50 The diverse prospects for nanomedicine to tackle Covid-induced clotting and related inflammation https://t.co/b6TNXIFHaZ @NatureNano @peijerussell @NicoVoelcker @MIPS_Australia https://t.co/25DyKFvYvG
2022-12-18 19:00:07 The US "senior wave" of Covid hospitalizations has already exceeded the summer BA.5 wave and may soon surpass the Delta wave. Most of these admissions could have been prevented with a booster shot. https://t.co/plG8BngKxy
2022-12-18 18:49:44 @billbrown Historically yes. Both those challenges have now been squarely addressed in thousands of such diagnosed patients with costs of desktop sequencing and reagents not a barrier. Think about the cost of 1 day in the ICU
2022-12-18 18:41:18 @nanopore @GSTTnhs Thanks @nanopore. I forgot about that paper (even though I posted it at the time it was published last year). I've revised the substack to include it and appreciate all you're doing to make clinical metagenomics the standard of care
2022-12-18 16:28:20 Rapid sequencing of a person's blood or relevant body fluid can determine the root cause of a serious infection. Why isn't this standard medical practice?https://t.co/Y8eZSBaTZIhttps://t.co/dFklQ7Y4Yg
2022-12-18 01:43:22 @alexmeshkin @WHCOVIDResponse February 2023
2022-12-18 01:40:48 Impressed. Ordered 15 Dec
2022-12-17 22:32:50 @mdhhsu I did
2022-12-17 22:15:11 Why don't we use rapid sequencing (metagenomics) to identify the cause of sepsis? https://t.co/Y8eZSBaTZI
2022-12-17 16:08:09 When you consider that much of the new data on bivalent booster protection is based on comparison with people who have had multiple shots and boosters, and infections, it's particularly impressive https://t.co/sAxR8IxKgr
2022-12-17 16:03:32 Sorry, that's @fmanjoo
2022-12-17 15:57:56 @Veinless @kyle_minogue @CDCMMWR The BA.5 bivalent, the only bivalent in the US
2022-12-16 22:02:25 @cwarden19 Thanks for your reply. I’ve put a clarification about the comparator group and context with prior reports
2022-12-16 21:59:25 Clarification: this study compares vaccine-induced myocarditis with viral myocarditis (not Covid). There are several other reports that I’ve previously posted w/ direct comparison with Covid myocarditis
2022-12-16 21:48:00 RT @thehowie: "If you want to give a great holiday gift to any and all seniors you know, that could be life-saving or prevent a hospitaliza…
2022-12-16 21:19:48 The natural history of vaccine-induced myocarditis for outcomes such as heart failure, dilated cardiomyopathy, or death is far different—more favorable—than from Covid myocarditis (besides the latter being considerably more common) https://t.co/2de1Eth12Nhttps://t.co/UKOMRKYNt0
2022-12-16 20:27:19 Where is the new @NIH Director with Francis Collins having stepped down a year ago? @hholdenthorp is on it https://t.co/WtwrtcHIi7 @ScienceMagazine https://t.co/fLHV76Sufz
2022-12-16 20:15:30 Here's my quick update for what we now know about the bivalent booster impact on outcomes https://t.co/sAxR8IxKgr
2022-12-16 18:53:14 Until now the immune escape of BQ.1.1 and XBB has been largely (if not exclusively) assessed via neutralizing antibodies. Here are new (in silico data): the T cell responses (CD4+, CD8+) are likely intact vs these variants, which helps prevent severe Covid https://t.co/j2ycDYFtU1
2022-12-16 16:53:20 A call to action for rebooting randomized clinical trials by leading cardiologists, published in @CircAHA @JACCJournals @ESC_Journals https://t.co/DB454UYfWY particularly to use digital technologies, reduce cost, improve efficiency and speed https://t.co/R8u58iSId9
2022-12-16 00:10:32 200 years after the birth of Louis Pasteur, the most visible scientist of his century "Perhaps no one better symbolizes the fundamental role of science within medicine" https://t.co/sBeQbiO3DP @TheLancet's new theme issue is rich with reviews, perspectives https://t.co/wmXbGU4s5I
2022-12-15 19:03:30 What is @ScienceMagazine's Breakthrough of the Year? The James Webb Space Telescope Runners-up include progress in RSV vaccine, the Epstein-Barr virus associated with multiple sclerosis, foundation (creative) models #AI https://t.co/Dp0oiR2txZhttps://t.co/98C8bV38WPhttps://t.co/hesn4Uneg6
2022-12-15 16:42:50 The broad benefit of SGLT2 inhibitor drugs (sodium/glucose cotransporter 2) in patients heart failure with preserved ejection fraction and symptoms https://t.co/SJsGxIedjt @NatureMedicine today
2022-12-15 00:59:49 RT @EricTopol: We've never had medications that can safely achieve ≥20% body weight loss. With over 1 billion people with obesity and >
2022-12-15 00:37:15 Returning to free Covid tests in the US . They'll come in handy with upcoming gatherings, especially with the current wave gaining steam. Ordering starts tomorrow https://t.co/t7GnkZ8Qva
2022-12-14 21:43:32 "Loss of smell and taste during COVID-19 infection are strong predictive factors for a robust immunologic response based on IgG [antibody] titers" https://t.co/2sbGdI1R2G @PLOSOne @ColumbiaOto @ColumbiaMed
2022-12-14 21:23:18 Can an intermittent fasting (IF) diet reverse Type 2 diabetes? A small randomized trial says yes, w/ 47% of IF-assigned participants achieving remission for at least 1 year vs 3% of controls (odds ratio of 31
2022-12-14 21:11:55 All is not quiet on the Asian-Pacific front (besides China) https://t.co/ON6Xhw2DvP
2022-12-14 20:48:39 @LisaAMcCorkell @Nature @yunlong_cao I feel so lucky to have worked with you, @ahandvanish, and @julialmv on the soon to be published #LongCovid review paper in a @NaturePortfolio journal
2022-12-14 20:24:24 @yunlong_cao @Nature @LisaAMcCorkell We are all deeply appreciative of the fine work that you and your colleagues have done to extensively characterize #SARSCoV2 variants , and published the data, well before they declare themselves clinically
2022-12-14 19:04:08 RT @bel10: This is a really positive, hopeful read if you need one today. Actual lasting silver linings of this pandemic have been few and…
2022-12-14 18:48:52 This is what not protecting seniors results in.... Add the BQ.1.1 variant to under-boosting, lack of mitigation factors On the way to exceeding BA.5 variant wave peak https://t.co/axTWPiQjNE
2022-12-14 18:29:58 Impressive work by @Lenka_Dohnal @nitaidean @sellmyerlab @FitzGerald__Lab @PSUmetabolomics @BaurLab @AmberAlhadeff @Helfrich_lab @MaayanLevy_Lab See thread by @ThaissLab Hope they have a @redcube link for those with access issues https://t.co/5G7ByqA1Q5https://t.co/4XutRKAqmo
2022-12-14 18:20:13 RT @alexnatarosMD: Excellent synopsis of @elonmusk-era #MedTwitter @CMAJ Highlights MDs to “counter &
2022-12-14 18:09:15 Among @Nature's Top 10 people who shaped science in 2022, big congratulations to @yunlong_cao Covid predictor and @LisaAMcCorkell #LongCovid advocate https://t.co/i7KcjWRQMyhttps://t.co/AMGURebvvy
2022-12-14 16:40:47 The deaths from Covid in the first 2 years of the pandemic were nearly 3-fold reported—~15 million globally—by @WHO excess death calculations https://t.co/YwZHD4ufC1 @Nature https://t.co/sE7wVs0tWR
2022-12-14 15:32:28 PML (progressive multifocal leukoencephalopathy) is a rare, dreaded and often fatal brain infection that can occur after immunosuppressant drugs. The potential for screening gene variants to avoid PML is raised here https://t.co/XN9MjUU0Dshttps://t.co/CtZSXWtPDa
2022-12-14 15:17:44 Just published @CellCellPress "Alarming antibody evasion properties of rising #SARSCoV2 BQ and XBB subvariants" These are the current US variants to reckon with. Were it not for the immunity wall that's been built, we'd be having a much rougher go at it https://t.co/VqxKpU5ZKuhttps://t.co/3WjcHL7jPB
2022-12-14 01:26:34 In just 3 weeks using the mRNA platform we've seen: —a universal flu vaccine effective in multiple experimental models https://t.co/CfABwulTzS —1st sign of efficacy in a cancer randomized trial (vs Stage 3/4 melanoma) https://t.co/KtwPrwq9oOhttps://t.co/LEmljWiqbd
2022-12-13 18:59:15 The ongoing Covid "senior wave" in the United States, already has surpassed the BA.2, BA.5, and soon Delta waves for hospital admissions among people age 70+ https://t.co/Cze8bZxwXr Most admitted have had 2 shots but w/o a booster in >
2022-12-13 14:32:57 @HelenBranswell @WHO @JeremyFarrar @wellcometrust Yes, this is big news. Congratulations @JeremyFarrar for your new post! And to @WHO for recruiting him
2022-12-13 12:09:00 The 1st randomized trial of an mRNA cancer vaccine to show efficacy: Stage III/IV melanoma, a combination immunotherapy + vaccine was superior to immunotherapy alone for recurrence-free survival. 157 participants (Phase 2b) w/ large trial planned PR by Moderna &
2022-12-13 02:14:16 RT @FutureDocs: @EricTopol it’s like he wants us all to go but we should not comply
2022-12-13 01:57:06 If the #ScienceTwitter &
2022-12-13 00:09:49 For people with Type 2 diabetes, an open-label randomized trial of a low carb, high fat diet vs hi carb, low fat showed substantial benefits for 6 months that were not sustained during follow-up https://t.co/VsqmlejcE1 @AnnalsofIM @AleksanderKrag @Camilla_Dalby https://t.co/NzN4JyxBHY
2022-12-12 23:52:08 France has withstood the challenge of the BQ.1.1 variant fairly well as the 1st country to see it achieve dominance, an encouraging sign relative to its immune evasiveness @OurWorldInData and https://t.co/kraBgpXvtvhttps://t.co/LYAzvwikiI
2022-12-12 23:22:10 Significant reduction of hospitalization (by 40%) and deaths (by 70%) among patients who received Paxlovid vs controls in a large US health system (@MassGenBrigham) https://t.co/adjB62nooJ @AnnalsofIM @AnnWoolleyMD @SDrydenPeterson https://t.co/m1NgJXAvBI
2022-12-12 19:46:22 Part of the explanation for why there's a lot of variability for neutralizing antibodies after Covid: genomic variants in the imunoglobulin heavy chain https://t.co/UUvqfOrbfh @ImmunityCP https://t.co/dLm7N5ktWi
2022-12-12 16:50:55 RT @EricTopol: I wrote about the new anti-obesity drugs—semaglutide (Wegovy) and tirzepatide (Mounjaro)—that represent one of the most impo…
2022-12-12 16:33:54 Postural orthostatic tachycardia syndrome (POTS) can occur after Covid and in the 90-day period following vaccination. It is 5-fold more common with infection https://t.co/MYMYvt1sOJ @NatureCVR @CedarsSinai https://t.co/PR390ypkET
2022-12-11 20:45:18 "When it comes to protecting seniors, we’re doing a terrible job of that in this country” https://t.co/vGLtcHNLyw by @CarlaKJohnson @laura_ungar @AP @APHealthScience In many states, Covid hospitalizations for people 70+ are higher than during their BA.2 and BA.5 waves https://t.co/ptqvUcngqH
2022-12-11 18:32:11 Why are long-lived lung, tissue-resident memory T cells so important vs Covid ? https://t.co/BOBSmGZrLi @NatRevImmunol Francis Carbone @TheDohertyInst @UniMelb https://t.co/JbYAAli0mV
2022-12-11 17:47:29 We've never had medications that can safely achieve ≥20% body weight loss. With over 1 billion people with obesity and >
2022-12-11 17:08:58 My friend, @UrnovFyodor, a pioneer of genome editing, lays out his vision and deep concerns about "word-processer- like control over DNA" "The invention of CRISPR gene editing gave us remarkable treatment powers, yet no one should do a victory lap." https://t.co/49OwXvP7kghttps://t.co/3RV3I37sHl
2022-12-10 20:41:51 I wrote about the new anti-obesity drugs—semaglutide (Wegovy) and tirzepatide (Mounjaro)—that represent one of the most important breakthroughs in medicine https://t.co/SMZO20ExDk
2022-12-10 16:45:42 We're now in the era of spatial biology: it's not only possible but becoming essential to define the spatial process &
2022-12-10 16:26:05 "These observations indicate the need for development of mucosal vaccines to induce potent immune responses at sites where #SARSCoV2 infection occurs." https://t.co/OJQuUipaHi H/T @chrishendel https://t.co/tWhL61J2mu
2022-12-10 15:33:09 Just out @NEJM, a "milestone" The level of neutralizing antibodies induced by Covid vaccines has been established as a correlate of protection, i.e. a surrogate endpoint for predicting clinical outcomes and use for regulatory approvals https://t.co/CLMoASrRnthttps://t.co/ZBIIb9rFsM
2022-12-09 18:36:00 RT @davelevitan: Just because this tool is pulling from millions of peer-reviewed papers doesn't make its conclusions true or good. "You…
2022-12-09 17:27:56 In the same time frame September to now, look at booster uptake in England among 65+ seniors (>
2022-12-09 16:37:30 The GATTACA film 25 years later Its "prescient forewarnings are still relevant today in light of the current trajectory of genomic science and technology." by @dovgreenbaum and @MarkGerstein @NatureGenet https://t.co/0jBNjgwaTPhttps://t.co/kpn25pUOIN
2022-12-09 16:23:39 —90% of Covid deaths in the US are now in people age 65+ —94% of Americans age 65+ have had 2 shots, but majority with no booster, only 34% with bivalent booster https://t.co/5wOCpbxZO1 @dwallacewells @nytopinion
2022-12-08 21:41:13 @richardludlow @NatureMedicine @ma_hamer @M_Stamatakis No cause and effect established or asserted
2022-12-08 19:46:05 RT @hholdenthorp: Enjoyed talking to Tony Fauci about the last few years and what lies ahead. Lots of great stuff in here for science polic…
2022-12-08 19:22:32 No problem, I'll code for you #AlphaCode https://t.co/7m41MgwHUM "This result marks the 1st time an #AI system has performed competitively in programming competitions" @DeepMind @OriolVinyalsML Not so fast. What it can and can't do. https://t.co/lasA1mJK08 by @zicokolter https://t.co/QqRYL14VJh
2022-12-08 18:40:15 Why does having a human cell atlas, with single-cell and spatial definition, have such transformative potential in medicine? https://t.co/l1II0q1was by @jennyErood @AidMaart @teichlab @GraphicAnja Aviv Regev @NatureMedicine https://t.co/0ZSvKnYaMg
2022-12-08 16:51:44 The conclusion is worth reviewing —1 minute bursts, 3 to 4 per day —for non-exercisers, there's hope —these finding only possible via ~25,000 people from @uk_biobank, wearable sensors, and #AI analytics —1st research to measure VILPA effects https://t.co/ECoOUmaaOo
2022-12-08 16:45:19 @paulg @NatureMedicine @ma_hamer @M_Stamatakis Yes, correct. 1 minute bursts made a difference, 3-4 per of these per day associated with the protection
2022-12-08 16:34:59 Vigorous intermittent lifestyle physical activity (VILPA), 3-4 minute bursts per day, associated with ~40% reduction of all-cause mortality, cancer and cardiovascular mortality https://t.co/BoGmigjqWl @NatureMedicine @ma_hamer @M_Stamatakis https://t.co/UPx61oh4Gs
2022-12-08 16:19:41 Subsequent development of #LongCovid detected by gene expression during acute infection. Two different patterns related to antibody production to spike protein https://t.co/ZklAmwyk4L @NatureMedicine @noambeckmann1 @IcahnMountSinai https://t.co/7uklWADq7e
2022-12-08 15:18:00 RT @Yale: PODCAST: @thehowie and @hmkyale are joined by Dr. Eric Topol, a physician and writer to discuss his career turn toward genomics a…
2022-11-13 22:29:15 RT @pnatarajanmd: .@EricTopol discusses the exciting advances in more cost-efficient timely clinical while genome sequencing. Uniquely, the…
2022-11-13 21:11:24 @DeAnnGlobalHea1 @washingtonpost @PostOpinions I do the best that I can with the data that are (or when they are) availablehttps://t.co/DzBiZvrXBN
2022-11-13 21:06:43 I'm getting criticized for not highlighting more parts of the editorial. Here's the updated highlighted version https://t.co/zMgnTgISos
2022-11-13 20:30:13 Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so much attention has been on the lowering of cost, [sample ->
2022-11-13 17:03:30 @Mssarahmssarah @washingtonpost @PostOpinions Sure. I could have highlighted every word—it was that good
2022-11-13 16:51:53 Excellent, pitch perfect editorial on the new variants and current status of the pandemic, by @washingtonpost editorial board todayhttps://t.co/zdU2fPCTpJ @PostOpinions https://t.co/CmrSN3RsyW
2022-11-13 02:17:15 Nevada. Winner Catherine-Cortez MastoSenate retained control to Democrats just now
2022-11-12 23:37:46 @nlj @OurWorldInData That's right and I stand by it. If Omicron had not arrived, the pandemic would have been over after Delta.My statement was very clear: "If there's not a worse than Delta...." And there was. Period.
2022-11-12 23:32:57 The same applies to excess mortality for the world.Yet so many people are unreceptive to any good news https://t.co/6X15RMUv0W
2022-11-12 16:03:21 Covid has been associated with an increased risk of both Type 1 (autoimmune) and Type 2 diabetes, but there are many unresolved questions. A good perspective piece @NatMetabolism https://t.co/d1cnHGukq8https://t.co/3bYG7uLvPz
2022-11-11 23:06:07 @chrischirp good to see this!
2022-11-11 17:43:13 @mlipsitch Agree with your point, Marc, but disagree that vaccines provide adequate/durable protection vs symptomatic (re-)infections. That was true through Delta but there's been marked erosion of that protection since Omicron in late 2021 and its descendants
2022-11-11 16:57:58 What is encouraging is that New York State, the highest BQ.1.1% in the US still shows no sign of increased Covid hospitalizations. Same for the US overall https://t.co/fGkw5lysLP
2022-11-11 16:49:00 A simplified map of human metabolic pathways
2022-11-11 15:55:31 New US Covid genomics: the BQ.1 variants have risen to account for 44% of cases, with BQ.1.1 at 24% (18% a week ago), as BA.5 rapidly fades. BN.1 shows some increasehttps://t.co/jjl2AnOYb5https://t.co/94vLZ04aXA
2022-11-11 15:25:02 A new first-rate review of how the mRNA-nanoparticle platform is moving in clinical trials of infectious diseases, cancer, protein therapy and genome editing. And the many innovations in storehttps://t.co/esvgsHWF9y @NatureMedicine https://t.co/F2gYQgMRrL
2022-11-11 15:04:07 RT @EricTopol: The daily pandemic briefing Ground Truths today is on 2 publications regarding Covid reinfections and #LongCovid https://t.…
2022-11-11 02:58:10 @ValdaVinson @hholdenthorp @oooitsplasma @hoelza She’s the best life science graphic artist!
2022-11-11 01:31:36 The daily pandemic briefing Ground Truths today is on 2 publications regarding Covid reinfections and #LongCovid https://t.co/QyJtagZamT
2022-11-10 23:00:44 RT @larrybrilliant: No one knows if this winter will see a surge, a wave, or a flat and even decreasing level of cases and deaths from COV…
2022-11-10 22:32:39 New @SciImmunology —Covid vaccines neutralizing activity is almost entirely to S1 subunit of the spike—2-P substitution works well to nAbs, 6-P would likely be better—Better vaccines can and should be madehttps://t.co/u0TBY4KXBU by @veeslerlab
2022-11-10 22:23:33 The best review of tissue macrophage cells—critical for both preserving health and their role in many diseases—that I've seenhttps://t.co/5brtq516qI @CellCellPress @MiriamMerad @SinaiImmunol @park_mstreet @AymericSilvin @FGinhoux @SinaiMSTP https://t.co/FetlDBc74X
2022-11-10 19:24:51 New report from Germany of a large matched-control #LongCovid study of 157,000 people w/Covid, including ~12,000 children and adolescents"The results of the present study indicate that post-Covid-19 cannot be dismissed among children and adolescents."https://t.co/JvNgibLw21https://t.co/sryOmAY4uI
2022-11-10 18:07:18 RT @EricTopol: Today's Ground Truths, pandemic briefing, on booster waning, brain fog with #LongCovid, and potential of Paxlovid resistance…
2022-11-10 18:00:58 Documenting #SARSCoV2 evolution in deer and a deer-to-human transmissionhttps://t.co/jlMwOcIvOj @NatureMicrobiol by @jeffcbowman @SMubareka and colleagues @UofTEPIC @UofT
2022-11-10 16:58:19 Vaccine status was not protective vs reinfection sequelae, which is why we need nasal vaccines to achieve mucosal immunity, limit infections, reinfections, and spread. Since the arrival of Omicron, we've seen limited (effectiveness &
2022-11-10 16:16:36 All-cause mortality, hospitalizations and adverse sequelae are increased by reinfection, not just in the acute phase but during 6 month follow up https://t.co/6Uulb3fxGa
2022-11-10 16:16:34 Graphic of adverse outcomes by number of infections, a dose-response relationship https://t.co/mmM9zA9sn5
2022-11-10 16:11:29 Covid reinfections are bad for your health. Big @DeptVetAffairs study published @NatureMedicine today. #LongCovidhttps://t.co/1ZMbAnolSiby @zalaly and colleagues https://t.co/OXD2uGpVZ1
2022-11-10 01:43:56 Today's Ground Truths, pandemic briefing, on booster waning, brain fog with #LongCovid, and potential of Paxlovid resistancehttps://t.co/qMi0fhXEOJ
2022-11-10 00:36:28 The 4th shot (2nd booster) induced a good, sustained neutralizing antibody response but its protection vs infection was less durable (lasting ~3 months) than the 3rd shothttps://t.co/6sAPJvJAR6 @NEJM https://t.co/TavoVpkfVb
2022-11-09 18:11:39 "We thus identified a recovery-organizing neuronal subpopulation that is necessary and sufficient to regain walking after paralysis"Restoration of walking capability in 9 patients with spinal cord injuryhttps://t.co/Jr8FepTreohttps://t.co/1tsvSyfQH6@Nature @EPFL_en @gcourtine https://t.co/Fm8xtZag3V
2022-11-09 16:27:41 In pregnancy, a 10-fold higher #SARSCoV2 antibody from vaccine compared with Covid infections and enhanced protection for the newbornhttps://t.co/5Q3xzq6Q4Q @JAMANetworkOpen @dus10flan @ChildrensPhila @karen_puopolo @PennMedicine
2022-11-09 15:43:51 A new review of how mRNA vaccines work and the multiple ways the mRNA-nanoparticle platform can be improved to be more effective with less side effects (that is hardly being pursued)https://t.co/Wik2hH2pLN @ImmunityCP by @rein_verbeke and colleagues https://t.co/qXIjXzYOnd
2022-11-09 04:13:35 Polls. Schmolls.Again
2022-11-09 03:09:53 RT @mehdirhasan: Covid didn’t even get a mention in these midterms. Absolutely crazy.
2022-11-08 18:51:13 RT @jrfunke: Good news: "This uncoupling of lab assays of immune escape vs a benign clinical outlook is the first we have seen in the pande…
2022-11-08 16:51:04 RT @EricTopol: The reasons I think it's essential for #ScienceTwitter and #MedTwitter to stay with @Twitter right now—Spread the truth/fac…
2022-11-08 16:28:55 A brilliant review of the role of immunity in Alzheimer's disease and its potential as a target for therapyhttps://t.co/aZXEDZVYRtby @xiaoyingchen36 @holtzman4 @WUSTLmed @ImmunityCP @WUADRC https://t.co/edCSx5kE1D
2022-11-08 15:16:05 The impact of #LongCovid on the American workforcePersistent loss of ~500,000 workers"A mass disabling event"—@Cutler_econ https://t.co/PxnX3S69nS by @sinoceros @laurenweberWSJ https://t.co/ID1GlOQVBJ
2022-11-08 14:56:54 RT @EricTopol: An optimistic outlook (with caveats)My daily pandemic briefing, #6https://t.co/yEQ6h5f4KW If you find these useful, please…
2022-11-08 05:21:07 @DrJayneMorgan Thank you!
2022-11-08 03:56:36 @rquiroga777 Noted and thanks for pointing this out. Time will tell on the BQ.1.1x
2022-11-08 03:31:45 @iaincheeseman @StearnsLab @BlaineyLab @lukebfunk @WhiteheadInst @broadinstitute @CellCellPress Sorry on the misspelling, Iain. What a remarkable resource you and your colleagues published today
2022-11-08 02:02:31 @vaccinate Much appreciated!
2022-11-08 01:55:57 An optimistic outlook (with caveats)My daily pandemic briefing, #6https://t.co/yEQ6h5f4KW If you find these useful, please subscribe and share. They are free and always will be.
2022-11-07 22:03:42 How to determine all the essential human genes?Analyze >
2022-11-07 20:39:49 The prolonged recovery of consciousness in some patients with severe Covid is unusual. The brain state and pattern resembles the painted turtle and may be protective https://t.co/nFrLle1l4L @PNASNews https://t.co/iLVbiS1m9y @NYTScience @carlzimmer https://t.co/JbtKcSa4FO
2022-11-07 17:01:39 So you want to take down all the β-coronaviruses?Yet another path to broadly neutralizing antibodies as a template for variant-proof vaccines—the stem helixhttps://t.co/NkBfjUstbz @cellhostmicrobe @NIAIDNews @scrippsresearch https://t.co/b1SiuRtmiG
2022-11-07 16:06:21 As the BQ.1.1 threat fades in France (the bellwether), it's a preliminary good omen for the holiday season that we won't be facing a major waveAdd to this: the bivalent booster induces some cross-immunity protection vs BQ.1.1 &
2022-11-07 15:09:33 RT @EricTopol: The first study to show improvement in long-term outcomes after Paxlovid—including less #LongCovid, deaths, hospitalizations…
2022-11-07 00:37:56 Consistent and significant reduction of #LongCovid with Paxlovid treatment across all subgroups including age, sex, race, risk factors, prior Covid, vaccination, booster, unvaccinated https://t.co/T0oGWhfaTS
2022-11-06 18:07:24 The first study to show improvement in long-term outcomes after Paxlovid—including less #LongCovid, deaths, hospitalizations and complications—is a major advance. I've reviewed and contextualized it herehttps://t.co/bugfFk44sh
2022-11-06 15:31:37 The mean age of the participants in this study was 65.In the US, people age 70+ are the least likely to receive Paxlovid (missing out on acute phase benefit) https://t.co/5GuZG9BTwt
2022-11-06 14:32:46 That’s reduction (not reception)The further divergence of deaths and hospitalizations after the acute phase is notable
2022-11-06 04:23:52 @DocJeffD Thanks!
2022-11-06 04:23:27 The reception of #LongCovid and severe outcomes in the post-acute phase, associated with paxlovid treatment, was independent of vaccination, booster, prior infection or unvaccinated status https://t.co/Ivrdq4C701
2022-11-06 03:20:41 Breakdown of reduction by system and symptoms associated with Paxlovid vs controls https://t.co/4soa5duMyi
2022-11-06 03:13:37 Divergence of curves for reduction of #LongCovid https://t.co/DthdD50HMs
2022-11-06 03:06:58 Important new preprint just posted from @zalaly and colleagues
2022-11-05 17:21:53 RT @EricTopol: How #AI is transforming human embryo selection and improving in vitro fertilization. A renaissance in reproductive medicine…
2022-11-05 15:56:47 It's a good sign when you add 3 convergent mutations to BA.5's spike, have multiple lab assays showing much more antibody evasion for BQ.1.1, but we don't see any clinical sequelae (yet)Mutation map via @PeacockFlu More on this herehttps://t.co/8ikz6ZDm26https://t.co/HUQZz3L7Y1
2022-11-04 21:14:40 @cookyscan1 @RSNA @RadiologyEditor @cekahn @luker_md @arosenkrantzmd @ReedDunnick @ruthcarlosmd @DrLindaMoy @Abbara_UTSW Thanks @DavidBluemke @RadiologyEditor @RSNA for inviting me and I throughly enjoyed our discussion
2022-11-04 21:09:30 Europe hasn't look this good for new Covid hospital admissions for some time @OurWorldInData https://t.co/4Dm88BVF5C
2022-11-04 20:41:01 Will be staying and posting @twitter for nowAlso set up here at MastodonAnd will continue posting daily (brief) pandemic updateshttps://t.co/YllXW9J82kUntil this all gets sorted out https://t.co/SWDINcV5AY
2022-11-04 16:32:12 We now have 6 studies of the bivalent BA.5 booster->
2022-11-04 16:20:33 New York State has >
2022-11-04 16:01:28 New US CDC Covid genomicsBQ.1.1 now 19%, showing most growth advantage vs other variants (with BQ.1 combined ~35% of new cases)https://t.co/jjl2AnOYb5https://t.co/5gecIINrcm
2022-11-04 14:34:13 How #AI is transforming human embryo selection and improving in vitro fertilization. A renaissance in reproductive medicineOur latest @TheLancet digital medicine essayw/ @MrHadiShafiee https://t.co/W2Vc7iLglBhttps://t.co/mIRbfRvvsR
2022-11-04 13:28:48 Here are the data presentedhttps://t.co/RRhBYPPAUsAs seen by the Table above of the 5 recent bivalent reports, importance of live virus assay needs to be underscored.Also looks good from that standpoint vs BQ.1.1 https://t.co/DpPx7zFjbs
2022-11-04 13:12:00 More on the results, why 4-fold increase is very good, augmented response seen in people age 55+https://t.co/GkKlYHJnLd by @HelenBranswell @STATnews w/ @florian_krammer (excerpt below) https://t.co/VvnxPUyv8w
2022-11-04 10:45:00 Pfizer BA.5 bivalent booster data just presented by company press release, live virus assay:Compared w/ original booster, 4-fold increase neutralizing Abs vs BA.5 at 1 month Results very similar to @SutharLab below and very encouraging https://t.co/RH2G5NZ9lL
2022-11-04 01:54:29 Can we extrapolate the outcomes in France to the United States if BQ.1.1* proceeds here to dominance?Perhaps, but there is a major gap in vaccination and boosters favoring France https://t.co/BbZ3bkcg1h
2022-11-04 01:09:06 Correcting the Table (Shi study used a live, chimeric virus). Thanks @florian_krammer for noting https://t.co/QF6uUznCzF
2022-11-03 22:32:21 The BQ.1.1 variant's marked immune evasion in the lab is not playing out clinically to date. It is dominant (>
2022-11-03 21:27:15 Why are males predisposed to viral and vaccine-induced myocarditis?https://t.co/jJpekAAkPw @ScienceTM @SeanM_Wuvery likely steroid signaling mediated, lessons from immune-checkpoint inhibitor myocarditis https://t.co/n7pp7p3ZfI
2022-11-03 20:13:37 Special section @ScienceMagazine new issueOur interconnected brain with its ~86 billion neurons (and ~10,000 synapses with each one) when working well is a "synchronized symphony" with aesthetic featureshttps://t.co/8LEomFfvjShttps://t.co/Cltl3MJSSp
2022-11-03 18:16:56 Two new reports @PLOSGenetics on genomic susceptibility or protection from severe Covid1. A risk gene (TYK2) variant for lupus is protectivehttps://t.co/lmU3YYzLDU2. 5-fold increased risk of a rare TLR7 variant https://t.co/ZWi7hf9LaB
2022-11-03 17:06:46 It has taken 3 decades and a pandemic to actualize mRNA as a therapeutic platform, and now, with attention to improving efficiency/delivery, the potential applications are remarkably broadA new outstanding reviewhttps://t.co/ta3x0ZffEm@NatureBiotechhttps://t.co/LUgzWijRug
2022-11-03 14:47:21 The marked propensity for blood clots with severe Covid: antibodies to platelet factor 4 likely a contributorhttps://t.co/7grOoRnJxg @PNASNews @NIAIDNews https://t.co/Tf01jttH3n
2022-11-03 00:56:02 In it is a summary of the now 5 bivalent booster reports that compare its immune response (neutralizing antibodies) with the original booster. And vs the BQ.1.1 variant. https://t.co/KHTtZxw0cD
2022-11-02 21:59:19 A 5th report on the bivalent booster vs BQ.1.1 today reinforces the high level of immune evasion of this variant, with minimal difference for the bivalent ->
2022-11-02 21:50:48 A new, fourth assessment of the BA.5 bivalent booster showed augmented neutralizing antibody response to BA.5 compared to the original, but lacking a robust response to BQ.1.1, XBB and BA.2.75.2https://t.co/HUPkDil40vhttps://t.co/TEmivAXvhWhttps://t.co/j8qBPDERG1
2022-11-02 21:05:00 Real world mRNA vaccine effectiveness in children and teens, vs Omicron infections, Qatar https://t.co/puXbEE1tDqjust published @NEJM by @HChemaitelly @Laith_AbuRaddad and colleagues https://t.co/g97JwNe9jc
2022-11-02 20:40:26 @EladSharonMD @drorsos That’s right
2022-11-02 19:42:24 How #AI can unravel cellular immunity https://t.co/H6TBbz1Mn9 @ScienceAdvances @BerendSnijder @snijderlab @BenHale89559171 @ETH_en @IMSB_ETH https://t.co/LzAj2dlWUf
2022-11-02 19:25:06 For sepsis, quantifying immune dysfunction via whole blood RNA-seq or microarray led to accurate prediction of clinical outcomes across pathogens (including Covid) and age groups https://t.co/JkRq6w6soC #AI @ScienceTM @KnightGenetics @NDMOxford @OxfordMedSci @eddiecg https://t.co/ovfe8bJh9s
2022-11-02 18:20:18 RT @GaviSeth: A great graph. We are in a renaissance of Vaccinology. I can’t wait to see what new breakthroughs science will bring!
2022-11-02 18:16:33 There have been 3 bivalent booster reports w/ different results. Why?—Suthar lab used live virus, others pseudovirus—There was v small advantage (vs monovalent) for BA.5 nAbs (&
2022-11-02 17:30:16 Progress: an update of @MaxCRoser's @OurWorldInData famous graph that showed the hyper-accelerated Covid vaccine success, but many pathogens without a vaccine. Good news now for RSV (1st identified in 1956) and others with promising clinical trial data () https://t.co/6k9cy0vygd
2022-11-02 16:25:06 Impact of the rollout of an inhalable Covid vaccine in Chinahttps://t.co/okFulwr2Fr @FT @cansinobio_inc by @EleanorOlcott @WillLangley96 Yet nasal or oral vaccines get no priority or dedicated funding in the United States https://t.co/9ew7dS5X1G
2022-11-02 16:11:22 This reflect the immune evasion posed by BA.5 and replicates a few previous reports, such as this one (for age 18+).Also reinforces the waning immunity over time and reliance on boosters to maintain high level of protection https://t.co/J4fXDu3AaI
2022-11-02 14:42:10 The new data for the bivalent booster's broadening of immune response against the BQ.1.1 variant, summarized, in context with a new paper that frames the impact of boostershttps://t.co/IOVczxuB7k
2022-11-02 14:34:31 Condensates, the peculiar shape-shifting blob droplets inside cells, are being targeted for cancer and neurodegenerative diseases, among other conditionsA @Nature feature by @ElieDolgin https://t.co/1PZA3EnSbHhttps://t.co/pneNmUUwrl
2022-11-02 14:27:21 Confirmation of some loss of protection of vaccines/boosters vs hospitalizations and deaths in the BA.5 wave, age 50+, Ontario, Canadahttps://t.co/ycnwmaDveZ @DrJeffKwong @ICESOntario @PublicHealthON @UofT https://t.co/PyMY7YR2eU
2022-11-02 01:20:32 @SuzBrockmann Thank you!
2022-11-01 23:18:59 @SolliesSurgery Read on
2022-11-01 22:41:32 Here's my Ground Truths daily/frequent brief pandemic update for todayhttps://t.co/IOVczxdy5kIt's free. Subscriptions tell me that it's helpful.
2022-11-01 22:11:53 Some good news for the BA.5 bivalent booster Immune response protection vs BQ.1.1 and BA.2.75.2https://t.co/t08KNiBCKY @SutharLab live virus neutralization assay indicates broadened humoral immunity vs new Omicron subvariants (and neutralization >
2022-11-01 19:57:33 RT @ScrippsRTI: “With so many millions of people impaired, the need for accelerating clinical trials with promising immune-system-modulatin…
2022-11-01 18:49:35 I can remember the days when $1 billion/year for a pharma product was considered a blockbuster. Now Pfizer has 2—$34 billion for vaccines and $22 billion for Paxlovid—and they're markedly raising prices of the former "to offset weaker demand"https://t.co/aiCcxGPbtj @JamieSmythF https://t.co/GDoIKVARxS
2022-11-01 18:03:03 @LieslMcconchie @NatureComms @Lucie_Bernard_R @CadwellLab @YaleIBIO @VirusesImmunity Thanks. I plan to briefly cover that topic in my daily update later today https://t.co/YllXWa0b4k
2022-11-01 17:50:04 Not enthusiastic about daily or twice daily nasal sprays. Where are the nasal vaccines?https://t.co/eEipWNPNo5
2022-11-01 16:43:13 Some further potential evidence for immune imprinting from a nationwide Qatar study on vaccination, with or without a booster, for protection from Omicron -raddadreinfectionhttps://t.co/qEQm2vTwq4 @HChemaitelly @Laith_AbuRaddad and colleagues https://t.co/zQe0ceataU
2022-11-01 16:26:59 The gut-to-brain axis precise mechanism for how food poisoning and chemotherapies induce nausea and vomiting https://t.co/YyUG2CxY0A @CellCellPress @Tsinghua_Uni https://t.co/POLgCSiO1S
2022-11-01 15:34:42 Just published @SciImmunology The immune response gained from booster shots is largely confined to neutralizing antibodies (nAbs), not T-cellshttps://t.co/G8kB5jB1pT by @LabWalz @YMaringer and colleagues Which links the importance of nAbs to protection vs severe Covid https://t.co/ilIIP82G5D
2022-11-01 15:14:24 Beyond Covid treatments aimed at the virus, there's interest (and FDA approved drugs that can be repurposed) in targeting human protein kinases. And concerns.https://t.co/tZQbUhKGg1 @PostHealthSci https://t.co/Yxhg2TyuNH @scisignal @Tomer_M_Yaron @BrookHeaton5 @heatonlab https://t.co/9IlnmZd32h
2022-11-01 14:53:39 Covid infections disrupt the gut microbiome and increase vulnerability to secondary bloodstream infectionshttps://t.co/OMunSh31Xi@NatureComms @Lucie_Bernard_R @CadwellLab @YaleIBIO @VirusesImmunity https://t.co/7OT2okLeMj
2022-11-01 03:44:45 @mariat444 @Twitter @SubstackInc Will continue to post on Twitter unless or until it becomes unbearable. For the 5 reasons I outlined
2022-11-01 00:35:20 With @twitter's turbulence, I've decided to post a daily/ frequent brief pandemic update @SubstackInc, beyond the ones I do on biomedicine, #AI, &
2022-10-31 17:43:34 If you didn't like BQ.1.1's immune escape profile, then you really won't like BQ.1.1.10 and likewise for XBB add- on mutations (or BA.4.6.3, CH.1.1) https://t.co/IHIKgppPc4
2022-10-31 16:49:49 Good question. There's no good excuse why the US isn't aggressively pursuing thishttps://t.co/KkUyGYW9Ei @TIMEHealth by @AliceParkNY w/ @VirusesImmunity @CEPIvaccines @DrRHatchett @cansinobio_inc @BharatBiotech @NIAIDNews
2022-10-31 16:42:09 3 very good #AI papers today1. Graph neural networks #AI for biomedicine and #healthcarehttps://t.co/l5fHAbfNjV by @_michellemli @KexinHuang5 @marinkazitnik @natBME @broadinstitute @harvard_data https://t.co/3RqIbv2bR1
2022-10-31 14:08:21 The new variants with marked immune evasive properties are quickly picking up additional mutations. Important thread summary of a preprint just posted. https://t.co/RZofy5MNj6
2022-10-30 19:19:05 @MaskingForAll @Twitter Thank you. I do have a substack and will keep up with posts every couple of weeks or more frequently as warrantedhttps://t.co/YllXWa0b4k
2022-10-30 18:46:21 @morganstephensa What a great chapter and summary you put together https://t.co/fFhqwapn0L
2022-10-30 18:39:07 Graphs are the most recent data posted by @CDCgov https://t.co/HGyjNwCm0v
2022-10-30 18:36:14 The reasons I think it's essential for #ScienceTwitter and #MedTwitter to stay with @Twitter right now—Spread the truth/facts/good info—Counter &
2022-10-30 18:19:39 What if you had something that decreased death by >
2022-10-30 16:55:30 @theheatherhogan @fi_lowenstein @LisaAMcCorkell @priyakamal @chiluvs1 @dunkindona @karlitaliliana @PutrinoLab @WildNycgirl @VirusesImmunity your great chapter on dysautonomia
2022-10-30 16:49:47 What a remarkable #LongCovid info resource by 20 long-haulers &
2022-10-29 19:05:35 The #1 sleuth of life science data manipulation and imaging fraud, @MicrobiomDigest, has analyzed more than 100,000 papers since 2014. She reviews what she's learned and lays out what needs to change https://t.co/AYjYeVcrTP@nytopinionhttps://t.co/gw75OwQZb7
2022-10-29 17:27:33 Q—Before the pandemic, when was the last time an intervention's efficacy and safety was validated in >
2022-10-29 16:27:22 Song of the Cell, @DrSidMukherjee's new book, is an extraordinary work that covers the cell's history and future, along with its mysteries, like he did for genes in The Gene. Reviewed by @DShaywitz @WSJhttps://t.co/ec8WVRk0T6https://t.co/YUSxRINVEb
2022-10-29 15:25:57 A ranking of the immune evasion for the new variantshttps://t.co/1lrjUMGa9X
2022-10-29 15:15:15 An encouraging sign for one of the (if not the) most immune evasive new variantsXBB is dominant in India and Bangladesh without a rise in cases or deaths to datehttps://t.co/kraBgpFU4V and @OurWorldInData https://t.co/oZdLOXtoSI
2022-10-28 19:37:55 Long-lived plasma cells: real time, cell-by-cell time stamping of their immune response after vaccinationhttps://t.co/bKWGL3a5rp half-life of ~700 days in the mouse model @SciImmunology @MonashUni https://t.co/vRFXcnB8Jy
2022-10-28 17:21:41 @uche_blackstock I'm not going anywhere, Uché. That's how I first met you
2022-10-28 17:18:01 @Nate_DiCamillo @CellCellPress unlocking the article https://t.co/8OakGeNT0I
2022-10-28 17:08:59 The case for some vigorous physical activity: association with reduced mortality, heart disease and cancer in ~72,000 people, mean age 63, followed ~6 yearshttps://t.co/h6XY9Cqms4@ESC_Journals @uk_biobank @Matthew_Ahmadi_ @M_Stamatakis https://t.co/pzYJf68EsU
2022-10-28 16:54:42 "Compelling evidence for the role of carboxylic acid in guiding the mosquito's preference toward specific people"https://t.co/wredsoM8ux @CellCellPress https://t.co/EvMS4VES25
2022-10-28 16:32:26 via @chrischirp In England, the share of cases (and spurt) of BQ.1.1 and BQ.1 is similar to the USHospital admissions are currently on the way down (for now at least) https://t.co/FmfnifCxAT
2022-10-28 15:15:25 Besides the hopeful sign from France noted yesterday https://t.co/I4ujEQvJgw Region 2 of the US has the highest BQ.1.1/1, particularly New York, where new hospital admits have not shown a recent rise https://t.co/rcWUlpd8dk
2022-10-28 14:55:38 New US Covid genomics: BQ.1.1 and BQ.1 variants now account for 27% of cases, up from 17% a week ago, on a path to be dominant (>
2022-10-27 19:06:02 @BenIsraelow Delighted to do so, especially when it's so impressive and gives us much hope for a far better approach/defense
2022-10-27 18:30:09 Protective efficacy of the spike booster lasted for ~4 months, pan-sarbecovirus, using no adjuvants or replication-deficient or live attenuated virus (like FluMist), elicited broad neutralizing Abs.This is the variant-proof booster we need now to help prevent infections &
2022-10-27 18:16:56 Just published @ScienceMagazine A nasal vaccine booster (after primary vaccination) induces mucosal immunity —IgA, memory B and T cell—against the sarbecovirus family in the experimental modelhttps://t.co/j03xNjIXzhby @VirusesImmunity @tianyangmao and team @YaleIBIO @YaleMed https://t.co/M6LQUZWnlc
2022-10-27 17:44:25 RT @MassMedical: .@EricTopol said it would be a mistake to skip these shots. They still work, they just may not be much of an improvement o…
2022-10-27 17:39:01 Very hopeful signFrance is the 1st country in Europe to see the BQ.1.1 variant dominance (>
2022-10-26 21:05:00 The benefit of vaccination and boosters, along with prior Covid, against Omicron infections, in the California prison systemhttps://t.co/VSwHQIkwrD @NEJM https://t.co/3xg2Yn8DBm
2022-10-26 18:42:07 @Alexander_Tin @CNN @US_FDA @moderna_tx The number of participants in each of the 2 bivalent BA.5 booster independent studies is far greater than the ones Pfizer and Moderna have thus presented (zero) and are quite typical for assessment of neutralizing antibody response throughput the pandemic
2022-10-24 01:51:07 That Singapore's XBB variant wave was not severe, with relaxed mitigation, as @Fiona_M_Russell points out, is v encouraging https://t.co/tJuJ82OOBO —XBB's immune evasion could've ->
2022-10-24 01:21:15 @BagaiDr Many thanks Dr, Bagai!
2022-10-23 18:04:32 It's not a good sign when 3 shots and a breakthrough (BA.1) infection (lower panel) doesn't elicit neutralizing antibodies to some of the new variants (BQ.1.1, XBB, BA.2.75.2) https://t.co/YS9rbTlSGZ
2022-10-23 16:21:46 RT @paula_span: The new bivalent COVID booster: Older folks, a highly vaccinated group, appear less interested in getting it than earlier s…
2022-10-23 16:17:42 @elderconsult I think the likely explanation is a high rate of prior infection, particularly with the Beta variant which seems to provide more cross-immunity than the others
2022-10-22 22:09:29 Thanks for the critique and feedback, @AstroKatie, @choo_ek and many others. A sense of equivalency was never intended. Preventing deaths, hospitalizations and #LongCovid towers over any liabilities.Here's a fixed version https://t.co/hrlYbI8rEI
2022-10-22 20:10:45 For the first year of vaccines, over 20 million lives saved around the world through December 2021 https://t.co/4GnPgEvg7W
2022-10-22 20:10:44 End of July 202291% reduction of deaths, all ages https://t.co/GIPkSo2daH
2022-10-22 20:10:42 Vaccines and boosters save lives. Across all ages.96% reduction of deaths for 2 boosters vs unvaccinatedEnd of May 2022@OurWorldInDatahttps://t.co/UYkn5iszKT
2022-10-22 19:52:45 RT @cshperspectives: Sci comm irony when the first scientist quoted in a story has deleted their twitter account by the time the article ap…
2022-10-22 19:51:15 @JusDayDa @_TheAncientOne_ @MoritzGerstung Yes, that one is good, too. I had summarized it yesterdayhttps://t.co/fS78A4Vrwr
2022-10-22 19:32:01 @JusDayDa @MoritzGerstung Best I've seen is from @yunlong_cao and colleagueshttps://t.co/qWJ4AGtiur
2022-10-22 16:59:36 A review of how #AI has been used during the pandemichttps://t.co/tvjS0ifKFE @PLOSDigiHealth "No clinical trials evaluating any applications impact on patient health" by @RANDCorporation @carlberdahl https://t.co/GeoWpysyyj
2022-10-22 15:31:45 The BQ.1.x wave projection for the US, and calculations for many other countries based on growth advantage vs BA.5, by @MoritzGerstung https://t.co/4TozbJWNLahttps://t.co/wtuI1qLi4r
2022-10-22 14:15:56 Their XBB wave was projected to exceed BA.5.Strong NPI mitigation practices and very high vaccine/booster uptake (a top 10 country) likely contributed https://t.co/93Vd3T3Qg2
2022-10-22 14:05:17 This is very good news.The XBB variant wave in Singapore is in descenthttps://t.co/mZS5FePzrNXBB and BQ.1.1 are 2 of the most immune evasive variants and Singapore was the first country to experience a wave induced by one of them, now letting up https://t.co/DbkSC4OPN7
2022-10-22 01:27:48 @BMcranty @AstroKatie @Sarcasmorator I don't consider major reduction of deaths, hospitalizations, and #LongCovid as "meh"
2022-10-21 22:11:19 @AstroKatie I'm with you. Trying to provide as much balance as possible
2022-10-21 22:08:33 Yesterday's @CDCMMWR report that shows slippage of protection vs hospitalization after 4 months, age 18+, during BA.5 wavehttps://t.co/DRB7tiyffUhttps://t.co/1bTzbZvhAv
2022-10-21 22:05:10 @Sara43347888 The answer is NO. The @sfchronicle headline is terrible and worse than that is to have it behind a paywall. Unacceptable.
2022-10-21 20:45:55 RT @JohnRossMD: In case you missed it, UK COVID minimizer Francois Balloux has deleted his account after amplifying a spectacularly wrong p…
2022-10-21 18:27:42 RT @JReinerMD: Pfizer projects that it will make $32 billion from its COVID vaccine in 2022 and $22 billion from Paxlovid. Their plan to ch…
2022-10-21 17:41:28 The BQ variants and the UShttps://t.co/KEeCny0P9A by @ErinMPrater @FortuneMagazine
2022-10-21 16:36:27 RT @K_G_Andersen: BQ.1(.1)* picking up steam, but still too low to be making a major difference in cases/hospitalizations - follow this tre…
2022-10-21 15:59:15 That's right—Covid boosters aren't for everyone.But for WSJ to print this seriously flawed claim about cardiac deaths in men age 18-39 is inappropriate, to say the least https://t.co/KCox0mhlHGhttps://t.co/NixQ2Uki1R
2022-10-21 14:50:01 What are the #SARSCoV2 variants accounting for US cases?New CDC genomic surveillance updateOn the rise: Predominantly BQ.1 and BQ.1.1 (~17%), also BF.7 (7%), BA.2.75.2On the decline: BA.5, BA.4.6https://t.co/jjl2AnwOWXhttps://t.co/r7i6cYnjSe
2022-10-21 14:37:20 RT @mhornig: Not convinced efforts to avoid #SARSCoV2 infx are worth it? Think #LongCOVID and potential for #MECFS are fantasy? Please list…
2022-10-21 14:20:48 Myalgic encephalomyelitis was first recorded in 1934 in Los Angeles after an outbreak of atypical polio. It has taken nearly a century and #LongCovid to "get needed attention"https://t.co/ryyI15mfnf @NanetteAsimov #mecfs https://t.co/xOYiOk9R2A
2022-10-21 02:54:11 Keep an eye on New York, leading the country with % cases BQ.1.1, bellwether for the next wave https://t.co/vw77IAyHJj (update, first picked up by @JPWeiland) https://t.co/MPJSVvzqEY
2022-10-21 01:50:07 The inversion (next wave) is likely starting by the rise in hospitalizations. Great time for CDC to stop daily tracking https://t.co/RXymG9t41x
2022-10-20 23:56:25 On the imprinting issue, in the Discussion"antibody responses to some Omicron S[spike]-specific epitopes were hindered by prior antigenic exposure" https://t.co/w9oiWH8s5A
2022-10-20 18:57:29 Vaccination alone did not induce neutralizing activity in the nasal mucosa, but that was achieved via breakthrough infections."These observations... .motivate the development and evaluation of a next generation of vaccines administered intranasally." https://t.co/XIaSiKDJ7R
2022-10-20 17:17:31 Also to note that 60%+ max is not the 80%+ protection vs hospitalization that was consistently seen prior to BA.5, (90%+ for Delta and prior strains) and that finding replicates 2 other studies.Underscores the importance and need for a variant-proof, pan-sarbecovirus vaccine
2022-10-20 17:07:07 Why a booster is important to maintain protection from hospitalization: waning immunityNew @CDCMMWR shows the protection vs BA.5 drops down to 37% (2 shots) and 29% (3 shots) after 4 monthshttps://t.co/DRB7tiyffUData are for all ages 18+ https://t.co/Pa0PtdlWIY
2022-10-20 15:30:35 In a prospective cohort of critically ill adults, sequencing the blood (metagenomics) identified the pathogen 99% and predicted sepsis in 74%https://t.co/tQTgyQHSjY@NatureMicrobiol @UCSF @klkalantar and colleagues https://t.co/wx4u4HpqD5
2022-10-20 13:33:04 "Middle-aged people accounted for the biggest losses in life expectancy"https://t.co/czRQeP2WkHMore at "In America and eastern Europe, covid-19 got worse in 2021" https://t.co/SxZup76Cic
2022-10-20 12:47:01 RT @bmj_latest: “This virus is so amenable to taking it down . . . But we’re just not acting like we can do this. And we can.” @EricTopol…
2022-10-20 01:56:23 RT @EricTopol: There's a lot of total BS out there about myocarditis in kids and adolescents. To state facts:1. CDC does NOT decide about…
2022-10-19 22:20:40 For children 5-11 years in males, 2nd dosethe rate is 2.5 per million https://t.co/kXEH3wMsZl
2022-10-19 22:14:25 There's a lot of total BS out there about myocarditis in kids and adolescents. To state facts:1. CDC does NOT decide about Covid vaccines in schools 2. There are no kids dying of myocarditis from the vaccines3. It is very rare, mild 4. The anti-vaxx world has gone beserk
2022-10-19 21:56:45 The BA.4.6 variant accounts for ~12% of US Covid cases (pattern of growth below, left). Its level of immune escape was characterized @NEJM today: 2-3 fold less neutralizing antibodies than BA.5 (below, right)https://t.co/WdRlUvagsW @BarouchLab https://t.co/HCJYiczVfX
2022-10-19 21:06:24 Randomized, placebo-controlled trial of the 2-dose @moderna_tx vaccine in children 6 months to 5 years, during Omicron. Safe in ~4,800 kids
2022-10-19 21:00:25 New @NEJM"Our study indicates that [Pfizer] vaccine-induced myocarditis in adolescents appears to be a rare adverse event [<
2022-10-19 18:00:25 4. No increased risk of miscarriage or other pregnancy complications from vaccination or booster https://t.co/mVFxD3aE8e
2022-10-19 18:00:23 3. Newborn/infant (0-5 months) avoidance of hospitalization by mother's vaccination https://t.co/T2Wut9L6kK
2022-10-19 18:00:21 2. Vaccination protected vs hospitalization vs Delta and Omicron infections with booster (same with ED or urgent care visits)But 57% of expectant mothers have not been vaccinated or had a booster https://t.co/e9BEJwfVse
2022-10-18 23:34:04 RT @morgfair: I got my booster AND flu shot 3 weeks ago. Please consider making time to get these vaccines in order to protect yourself and…
2022-10-18 23:32:35 And it looks like the 25,000 threshold was not crossed after all, erroneous data @medriva https://t.co/tYv0wdLUup
2022-10-18 23:27:30 @JPWeiland Very strange, since they were in synch, ??
2022-10-18 23:19:33 Sadly, an inversion is in the works in the weeks ahead.And that will be amplified by lack of US booster protection, especially in age 50+, but there was 72% reduction of hospitalizations during BA.5 for age 18-49 https://t.co/M2Bu9rj1Vehttps://t.co/2mB1G9juGg
2022-10-18 23:09:33 Today is the first time US Covid hospitalizations went below 25,000 in 5 months https://t.co/Y2TdaIXScs
2022-10-18 23:02:07 Denmark's BA.5 wave. Prior Omicron infection plus booster had high protection against reinfection (93%) and hospitalization (96%). The risk of BA.5 hospitalizations was higher than the prior BA.2 wavehttps://t.co/0G1oRpViRd @TheLancetInfDis @C_HHansen @SSI_dk https://t.co/1hI1eg0PlH
2022-10-18 19:58:11 We've been thinking that the Omicron variant evolved from an immunocompromised individual with accelerated in vivo mutations. A new report @PNASNews raises the potential that it emanated from mice ->
2022-10-18 19:41:38 RT @florian_krammer: 1) Boston University researches have made a SARS-CoV-2 virus that has the spike of Omicron BA.1 and the remaining geno…
2022-10-18 18:46:11 The human asks: "Is there a bacteria on the slide?"The #AI responds: "Yes, indeed, and I've identified it for you"https://t.co/6d14dbMWAn @naturemethods developed by @KevinJohnCutler, a @UW physics grad student, with explanatory thread below https://t.co/axnXgss6qr
2022-10-18 18:01:02 Each day in the United States our immunity wall (vs severe Covid) develops more cracks in itWhy?Far more people have their vaccine or infection-induced immunity waned than are getting a booster
2022-10-18 17:24:41 ImmunosenescenceAdvanced age and reduced Covid mRNA vaccine induction of neutralizing antibodies and T-cell responseAnother reason why boosters, by preempting waning immunity, is so important in older age groupshttps://t.co/SF7YhiRIRs @NatureAging https://t.co/76cQS4hq5Khttps://t.co/U3gZaJgbax
2022-10-18 16:00:50 The XBB variant wave in Singapore will soon be their 2nd worst for the pandemic. The reinfection rate prior to the wave was 5% and now up to 17%, which tells us about the immune escape properties of this variant (akin to BQ.1.1, very high level of immune evasion) https://t.co/IMoMuymp75
2022-10-18 15:26:11 For essential workers, a recent (<
2022-10-18 15:15:22 The US purchased 171 million bivalent BA.5 booster shots
2022-10-18 14:32:36 Inflammation and dysfunction of the lining of blood vessels—the endothelium—is the basis for many of the cardiovascular complications of Covid. A new, solid review here https://t.co/1GiS8XXzT7https://t.co/CSBS7xjXCR
2022-10-18 03:49:18 RT @dnewheiser: In case it wasn't clear, the widespread prevalence of long COVID is a VERY BAD THING.@EricTopol explains that COVID is as…
2022-10-17 23:23:08 "The results reveal inequalities in molecular risk factors for chronic diseases often decades before diagnoses"Linking socioeconomic status (SES) and mRNA signatures of disease in >
2022-10-17 21:45:07 The choice of blood thinner for patients w/ atrial fibrillation &
2022-10-17 21:33:41 Why reducing the cost of insulin is critical"A total of 16.5% (95% CI, 13.8% to 19.6%) of insulin users rationed insulin ["to save money"] in the past year, or 1.3 million adults with diabetes nationwide."https://t.co/l6Vnd1WYD7@AnnalsofIMhttps://t.co/d7y1Borr49
2022-10-17 21:20:49 "Countries with a higher share of vaccinated individuals suffered the least life expectancy deficit."and to note bounce back of USA for age 80+ in 2021https://t.co/EM2Fq0hciJSummary of the paper@jschoeley @jm_aburto @ridhikash07 @OxfordDemSci https://t.co/gHSvgiTj90
2022-10-17 18:21:33 How to protect vs the XBB variant wave in Singapore?With the new and significant wave, cases are up, along with hospitalizations. The 79% population booster rate (double the US) is helping to avoid severe outcomes https://t.co/mZS5FePzrN @sporeMOH https://t.co/JVmgqD15OW
2022-10-17 18:06:14 Biomarker hunt for correlation with #LongCovid risk 7 months out from 108 people with mild to moderate Covid comes up with candidates such as Rig-1 and multiple cytokineshttps://t.co/lESwHXAmWv@eLifehttps://t.co/5q4qRgJxxU
2022-10-17 16:09:10 In contrast to most other countries, the life expectancy decline in the US occurred across all ages 20+ "In the United States, the pandemic has accentuated the pre-existing mid-life mortality crisis. This is clear from the strong contribution of increasing mortality <
2022-10-17 15:55:44 Making human salivary gland organoids to determine #SARSCoV2 infectivity https://t.co/GkOjqWt2c9 @NatureCellBio "SARS-CoV-2 derived from saliva in asymptomatic individuals may participate in the spread of the virus" https://t.co/cWRA6BgBi1
2022-10-17 15:11:30 Life expectancy changes during the Covid pandemic among 29 countries: the US among the most pronounced reduction. Several countries had bounce back improvement in 2021 (black arrows below). Vaccination uptake was correlated w/ less deficithttps://t.co/DIxN3ZrvsK @NatureHumBehav https://t.co/GE2VJMjP84
2022-10-17 14:25:01 Good review of the treatments that have been validated for Covid https://t.co/aavLANCV4A by @nymurakami @DavidLeaf9 and colleagues @BWHKidney @NatRevNeph https://t.co/WRqSbh81WP
2022-10-16 22:47:21 RT @JPWeiland: Something interesting is happening in New York. Cases have been flat over the past month, however hospitalizations are jump…
2022-10-16 18:25:06 The @sporeMOHreport on the XBB variant wave https://t.co/LwzJzRh2Hk…—Expects peak of 15,000 cases/d (>
2022-10-16 15:40:11 RT @florian_krammer: Ours is moving. Phase II in Mexico, Phase I in the US. But funding in the US for these vaccines is hard to find.
2022-10-08 14:50:36 The start of Singapore's XBB variant waveNotable how this variant left BA.2.3.20 in the dust, a variant with substantial growth advantage over BA.5
2022-10-08 01:55:55 Keep this summary data--preventing deaths--in mindhttps://t.co/Vc87IkH9WS
2022-10-08 01:34:54 A data-driven segment on vaccines and boosters worth watching.Thanks @chrislhayes for staying on this as we face a new wave in the weeks ahead with an exceptionally low (34%) booster rate (half that of all high income countries) https://t.co/N2K3QCptrz
2022-10-07 22:15:48 @DanRather To support you point, DanLives saved in 2021 by Covid vaccines and boostershttps://t.co/ICyk0xZBiG
2022-10-07 18:07:31 For more on today's UK report, an informative thread https://t.co/Dnz16oZ8ko
2022-10-07 17:54:04 New weekly US genomic surveillance https://t.co/jjl2AnwOWXBA.5 continues to fade as BA.2.75x creeps up, BF.7 (BA.5.2.1.X) &
2022-10-07 17:31:38 In a large US cohort of ~200,000 people who had Covid, vaccination reduced the risk of #LongCovid by 30-40% and this protection persisted through breakthrough infectionshttps://t.co/UqFViYOWdm
2022-10-07 17:02:35 A new profile on @Tuliodna &
2022-10-07 15:03:14 RT @EricTopol: @ArianaSeigel Since Omicron emerged, the vaccine/booster protection vs infection and spread has diminished and is less durab…
2022-10-07 14:15:21 RT @hholdenthorp: The medical establishment, especially @AAMCtoday and @AmerMedicalAssn, really needs to own the damage they are doing by n…
2022-10-07 14:10:56 The US booster rate (34%) vs peer, high income countries https://t.co/DVvWNke276
2022-10-07 13:51:21 @cindymclennan @NatureMedicine No, it's the BA.5 bivalent, but we don't have such data on that yet. This Beta variant bivalent was never made at scale
2022-10-07 13:39:46 New and encouraging @NatureMedicine on bivalent Beta booster"These results indicate that bivalent booster vaccines can induce potent, durable and broad antibody responses against multiple variants, providing a new tool in response to emerging variants"https://t.co/H5Q98bXoHahttps://t.co/reK5Jx99sx
2022-10-07 12:51:24 The US booster rate is less than half of all its peer countries, leaving Americans vulnerable now and as the next wave hits in the weeks ahead. By @ddiamond @VPMaryBeth @majohnso https://t.co/f4OYPlfvFd
2022-10-07 03:07:23 New on MolnupiravirA randomized trial of ~26,000 patients with Covid, mean age 57 with 2 days of symptoms, showed no difference in hospitalizations or deaths, the primary endpoint, compared with usual carehttps://t.co/6ai5AawdLnhttps://t.co/HIF845BRLx
2022-10-06 23:01:43 In my clinic today, after routine 6-lead ECG and during smartphone echo, a faster heart rate was noted. Repeat 6-lead ECG showed atrial flutter. All part of the extended physical exam with sensors
2022-10-06 21:06:12 Good summary today on this innovation and why time to diagnosis is so critical https://t.co/F5SxIIcsnQ @Medscape
2022-10-06 20:21:23 Masks help. So do vaccines and boosters.Japan has the lowest Covid death rate of any large country in the world, per capita https://t.co/adUZVdUcu8
2022-10-06 17:38:48 @TigerlillySusan BQ.1.1 is there but not at levels that would be driving a case wave (yet)
2022-10-06 17:32:23 Unlike Singapore, where the XBB variant wave has begun https://t.co/cT9YQbHiBn
2022-10-06 17:09:02 The #AI can "see" kidney disease from your retina and anemia from your electrocardiogramhttps://t.co/l8GkL5vyaC
2022-10-06 15:13:46 "During the pandemic, the practice [in Japan] became pervasive, though the gov't has never enforced a mask mandate... A recent survey showed that half of Japanese would like to keep wearing masks as much as possible, regardless of medical advice or rules."https://t.co/Avfztzfd0R
2022-10-06 14:32:12 It's "Data Liberation Day" in the United StatesPatients can now access all *their* health records A real liberation would mean having, controlling, owning all *our* medical datahttps://t.co/zATgTyrhhC @statnews @caseymross
2022-10-06 01:13:22 RT @TWenseleers: @EricTopol @Tuliodna This is the growth rate advantages I am getting of these different emerging lineages based on a fit t…
2022-10-06 01:03:25 The relationship between climate and CovidA comprehensive and very thoughtful assessmenthttps://t.co/Rb90ME8Rky @TheLancetPlanet @ccadapt @B_vanBavel @carolzavaleta and colleagues https://t.co/jwg3ZOrNBB
2022-10-05 23:37:54 @Tuliodna Hope you are right, TulioBut some of these look pretty menacing (especially BQ.1.1 and XBB right now)
2022-10-05 23:18:32 There has not been adequate regard for the level of immunity acquired from Covid infection, albeit with its attendant risk and unpredictable #LongCovid sequelae.I reviewed many of the earlier studies in this threadhttps://t.co/dWMGRpKKVa
2022-10-05 23:18:31 A systematic review for protection vs Omicron hospitalization or severe disease out to 6 monthsHybrid immunity + 3 shots 95%Hybrid immunity + 2 shots 96%Prior Covid alone 80%Vaccination (2 shots) alone 65%https://t.co/z0JxOhaaZM @nikbobrovitz @lsubissi https://t.co/JS2dSTpEj3
2022-10-05 21:20:50 Prior Omicron infections protected against BA.5 (~80% effectiveness) whereas prior Covid, non-Omicron protection was markedly lower (~30%). Likely related both to immunity waning and cross-immunity within Omicron lineageshttps://t.co/kEtABqGH97 @NEJM https://t.co/V9wjEcGczS
2022-10-05 18:33:27 RT @rkhamsi: Holy smokes! This is maybe the most important paper I’ve read in 2022…We know that this #COVID virus is good at hiding from…
2022-10-05 18:26:58 Knock 'em all out.Discovery by @EmoryVaccineCtr of a broadly neutralizing antibody (bnAb) vs all #SARSCoV2 variants through BA.5. Could be used alone or in combo w/ other bnAbs to make a variant-proof vaccinehttps://t.co/r3YDB1FOB0 @ScienceAdvances @SanjeevKumar_01 https://t.co/nUWf21gUuX
2022-10-05 16:42:27 "Alpha Tensor typically discovers thousands of algorithms for each size of matrix""Algorithms that multiply large matrices 10-20% faster than those commonly used on that piece of hardware"from the Cliff Notes versionhttps://t.co/8VPDQ2ySAThttps://t.co/ZhWI3enwhY
2022-10-01 01:18:36 RT @marypcbuk: I valye twitter for precisely this flattening
2022-09-30 23:14:54 Already high before the pandemic, the alarming current rate (63%) and increase in physician burnout "We cared about quality of patients' experience, building relationships with them"https://t.co/MJJfpv5kHk @oliverwhang21 w/ @JBryanSexton1 @JBryanSexton1 @MayoProceedings https://t.co/YhcozuPjQh
2022-09-30 19:05:57 RT @CatchTheBaby: @RajlabN Thanks. This is very helpful.BQ.1.1 is concerning since it is resistant to both Evusheld and Bebtelovimab. http…
2022-09-30 18:59:36 Broadly neutralizing antibodies (bnAbs) are the template for variant-proof, pansarbecovirus vaccines. A new review shows the extensive discovery work has been to find bnAbs, and these are just vs the spike protein!https://t.co/dN8XsURly3@NatRevImmunolhttps://t.co/3DvfXiwOHN
2022-09-30 17:54:15 Current data (28 September), for those past 6 monthsAge 65+, <
2022-09-30 17:08:44 Each day in the US we have far more people whose immunity has waned, >
2022-09-30 15:58:59 RT @Tuliodna: Early reflections of the historical event @Illumina genomics forum. In this short thread, I highlight that it is not the tech…
2022-09-30 15:16:20 New US genomic surveillanceAs the BA.5 variant proportion of cases descends, the rise of BA.4.6 (13%), BF.7 (aka BA.5.2.1.7
2022-09-30 01:19:05 For #AI to be an integral part of medical practice, compelling data from randomized and prospective trials are needed. A new systematic review of all 41 RCTs shows the weak status of what has been done to datehttps://t.co/Gj8ToPdGJZ @PlanaDeborah @dlshung @BenjaminKannMD https://t.co/WdJ7iZAy4z
2022-09-30 00:42:06 RT @TIME: "Hannah Davis (@ahandvanish)’s advocacy has been a light in the darkness for many people whose Long COVID struggles have been dou…
2022-09-29 22:00:38 "We show how this [science-guided] battle got lost on Facebook very early during the COVID-19 pandemic and why the mainstream majority, including many parenting communities, had already moved closer to more extreme communities by the time vaccines arrived"https://t.co/IMUyqA80Xohttps://t.co/qFrA74XBNs
2022-09-29 21:31:02 And here's a short video what we're doing for a universal, variant-proof Covid vaccine, via joint efforts of immunology and structural biology, with @DennisRBurton and Ian Wilson, @WardLab1https://t.co/yjYPkSBERa
2022-09-29 19:20:04 How to accurately identify an uncommon and lethal disease (IPF) 1 to 4 years sooner than in general medical practice?Train #AI with data from 3 million people, >
2022-09-29 18:40:43 My @scrippsresearch colleagues just published @nchembio a new oral drug vs Covid that blocks ACE2 binding to the spike protein, inhibiting viral entry and infections in the experimental modelhttps://t.co/lronrARbxUhttps://t.co/a18sJ64O1a
2022-09-29 17:49:30 @ImmunomePro @waynekoff1 @TedSchenkelberg So glad to be a part of this new and exciting initiative with planning over the past few days, bringing together leading immunologists and computer/data scientists from all over the world
2022-09-29 14:23:11 False positives and unnecessary biopsies frequently arise from mammography screening for breast cancer. A new study using #AI of MRI scans shows the potential for much improvement https://t.co/uCZy32IBlp @ScienceTM @JanWitowski @kjgeras@nyuniversity @nyugrossman and colleagues https://t.co/CsTpJA7EI7
2022-09-29 01:17:37 He basically summarized we've made solid progress with genomics research, such as with the @AllofUsResearch program, but slow to move to the clinical realmAgree. We'll get there eventually....... https://t.co/NmbW8oHwNc
2022-09-29 00:42:20 Good to hear @BarackObama’s candid appraisal of where we stand with precision medicine #IGF https://t.co/cfyBBeFy7i
2022-09-28 19:35:51 RT @Alex_Aravanis: Looking forward to hearing from @francesarnold, @EricTopol, @amyleecp3, @j_echevarria, @clopezcorrea, and @WohlgemuthJay…
2022-09-28 16:20:29 The Lasker-DeBakey Medical Research Award today for discovery of circulating cell-free fetal DNA, the foundation for prenatal screening. Congratulations to Dennis Lohttps://t.co/N8tKiMKoSQ @NEJM @LaskerFDN https://t.co/g2RXi6W3iz
2022-09-28 15:48:15 What may be the sequelae of the new variants https://t.co/f37WFDZaUn by @GretchenVogel1 @ScienceMagazine (hint: the pandemic isn't over)And my simplified version of @dfocosi'soutstanding convergence map highlighting the 2 variants discussed in this piece https://t.co/GwfrweY5iO
2022-09-28 14:29:15 A small pilot study of plasma proteomics in health care workers with mild Covid or controls suggests potential for predicting #LongCovid https://t.co/Nygcmq4VN8 @eBioMedicine @uclnews @gabycaptur @DrWendy_Heywood https://t.co/y7anc6T31W
2022-09-28 02:37:15 @Tuliodna @christian_happi @fdesouza @illumina Welcome, Tulio and team, to Capetown of the US, without Table Mountain
2022-09-28 00:12:24 Has the β-amyloid hypothesis for Alzheimer's (AD) finally been proven? Results of a Phase 3, placebo-controlled trial of a monoclonal Ab in 1,800 participants with early stage AD raises the possibility (need to see all the data)https://t.co/npXgPzNAhthttps://t.co/OYlvevWCNv
2022-09-27 22:53:24 The BA.4.6 variant now accounts for >
2022-09-27 22:16:49 How long is Covid infectious and what's the best way to track it that correlates with culture positivity?"Most adults have replication-competent #SARSCoV2 for 10-14 after symptom onset, and N antigen testing is a strong predictor of viral infectiousness"https://t.co/we0hTuzKjkhttps://t.co/uf1AVGd5ZT
2022-09-27 18:26:48 @dfocosi @TRyanGregory @florian_krammer @Tuliodna @CorneliusRoemer @PeacockFlu @DrEricDing @kakape @SolidEvidence @ewencallaway @RobertoBurioni @mlipsitch @JeremyKonyndyk Info overload!My dumbed-down version https://t.co/Vfq1xPrKHw
2022-09-27 18:03:50 Current CDC recommendations>
2022-09-27 17:11:56 A very interesting report that adds to the possible underpinnings of #LongCovid. Reactivation of viruses such as EBV has been raised, along w/ persistent remnants/reservoir of #SARSCoV2, and autoimmunity. But imprinting from a common cold coronavirus is unlike these mechanisms
2022-09-27 14:53:21 Good summary @PopSci integrates findings from a 3rd report https://t.co/R9AwAdv7cZ by @LPBaisas
2022-09-27 14:42:37 The persistent excess of arterial and venous blood clots after Covid at 1 year compared with controlshttps://t.co/phpGVQgCOh @CircAHA by @jonathanasterne and colleagues https://t.co/Q0ONqbnHr3
2022-09-27 13:56:37 @DFisman @kasza_leslie @VirusesImmunity Thanks David! Prime + nasal boostThe link for those interestedhttps://t.co/OujfFxvdS6 @SciImmunology
2022-09-27 01:34:49 These results are derived from ~450,000 people prospectively followed for 12.5 yearsChallenging medical dogma, arrhythmias were reduced by coffee (caffeinated, not decaffeinated), as was heart failure and strokeUsual caveats of self-reporting https://t.co/AUpZKemkW0
2022-09-27 00:23:53 Coffee lovers will love this new report
2022-09-25 15:57:46 @luckytran Over 200,000 Americans died from Covid in 2022 and still now >
2022-09-25 15:34:16 A good graphic on imprinting. We don't yet know how well the bivalent BA.5 will do, but boosters are our best shot for maintaining high level protection vs severe Covidhttps://t.co/aqOp2TpAUDSummary of what's known about boosters
2022-09-25 15:19:54 Sneak preview of what's to come from @JosetteSchoenma BA.2.75.2 and BQ.1.1 in 3 countrieshttps://t.co/qqPnt9vYqO
2022-09-24 21:55:55 @AlbertBourla @loscharlos "Back in mid-August"A reinfection in such a short time bespeaks the big unmet need to block infections and spread, which we're not going to get better at with shots at this point
2022-09-24 17:53:46 Nothing to worry about out there
2022-09-24 16:01:35 Our metabolites indicate risk of more than 20 common diseases beyond traditional clinical risk factorsNew @NatureMedicine report from ~120,000 participants, >
2022-09-24 15:51:26 Retina images are emerging as a window to blood pressure and glucose control, kidney and hepatobiliary diseases, risk of heart disease, and Alzheimer's. Could they be a biomarker for #LongCovid?https://t.co/AFUypPKoZthttps://t.co/DXhxQREHbD
2022-09-23 22:32:29 RT @captainslim: I’ve been enrolled in this study almost since it started. I’m fascinated by the idea of using passively collected data fro…
2022-09-23 20:31:25 Pandemic virus sequencing has provided the notable edge of seeing variants before they go exponential, characterizing them, determining in advance whether and which treatments (mAbs), vaccines will be effective More here: https://t.co/xr8J0OtwED by @PhilFebboMD_CMO
2022-09-23 20:22:53 And my prior post on 2 with immunoprofiling (BA.2.75.2 and BQ.1.1)https://t.co/p6F7JAUxFc
2022-09-23 20:21:00 New info on the major variants on the radar screen, by @yunlong_cao https://t.co/Qg4Nxc0W82
2022-09-23 19:59:30 These 2 large studies are consistent and concerning.Reminder: it took ~15 years after the 1918-9 pandemic to pick up the increased risk of Parkinson's disease among survivors.
2022-09-23 19:40:25 The immune system response &
2022-09-23 19:01:54 Work @ScienceMagazine w/ @ScienceVisuals Report by Yang Cao @zhenqi_zhou @MarcusSeldin @DOM_UCLA @KeckMedUSC @dgsomucla Perspective by @josephahill https://t.co/ts08EMj8BL
2022-09-23 15:36:24 Using epigenomics (methylation markers) a person's biologic age can be determined fairly accuratelyNow digitizing #brain age is getting attention via imaging #AIOur new @Lancet Digital Medicine essay@DavidJonesBrain @NaipMayo https://t.co/bA6ypagsJChttps://t.co/VRAx1Bk8r2
2022-09-23 14:39:15 For opera, "It ain't over till the fat lady sings"For the pandemic, It ain't over (contained, under control, ahead of it) till we get better vaccines that block infections and spread (e.g. nasal) and are variant-proof, pan-sarbecovirus
2022-09-23 14:11:17 And @EllingUlrich has an insightful thread about both the convergent and non-convergent mutations for the new variants https://t.co/M6yWQqErenhttps://t.co/WgB5SZXZEv
2022-09-23 14:11:16 Here @SolidEvidence has mapped out their evolutionary path with a convergence of several mutations https://t.co/XEfxyTn0n0
2022-09-23 14:11:14 New US #SARSCoV2 genomic surveillance dataThe proportion of BA.5 cases is declining, as new variants are out-competing, some of which have already been shown to have more immune escape such as BA.2.75.2 and BQ.1.1https://t.co/jjl2AnOYb5https://t.co/FUSgl3CAR0
2022-09-23 13:54:27 RT @NatureMedicine: In our latest Review: Multimodal #AI models could unlock many exciting applications in health and medicine
2022-09-23 01:41:31 The global Covid death toll would be more than double by now without vaccines (about 50 million people died in the 1918 influenza pandemic)https://t.co/RGe96GeJ5s
2022-09-23 01:31:34 Although we have no validated treatments yet for #LongCovid, a new @bmj_latest paper provides practical support and guidance for both patients and clinicians https://t.co/eBKGloKDEI by @trishgreenhalgh @sivanmanoj @bcdelaney1 @REvans_Breathe @ruairidhm https://t.co/1DGWMqjOxI
2022-09-22 23:54:39 Why wrist sensor surveillance should be part of pandemic monitoring https://t.co/2cTRFyybzg @LancetDigitalH by @jmradin @GiorgioQuer @JayPandit @ScrippsRTI @careevolution @SteveSteinhubl @BacaMotes @ERamosPhD @GadaletaMatteo @scrippsresearch https://t.co/0GyqYpqBif
2022-09-22 21:09:42 Think outside the spike (again)#SARSCoV2's ORF7a protein inhibits antigen presentation CD8+ T cells, may contribute to immune evasion https://t.co/toygmNWQxE@PNASNews @PaulBieniasz @RockefellerUniv https://t.co/ACjP7UYZHK
2022-09-22 20:33:26 @hholdenthorp @alanalda I love @alanalda Here's is our back and forth after I got the @ScienceMagazine review back for Covid and the heart https://t.co/Ql4PIA6rBE
2022-09-22 18:58:28 Why is obesity an important risk factor for severe Covid?@ScienceTM, a potential contributing factor #SARSCoV2 infects fat cells -->
2022-09-22 18:19:06 Discovery of a Sarbecovirus (Khosta-2) in Russian bats resistant to neutralization in serum from people who had Covid vaccineshttps://t.co/XTdua8Hwa0 @PLOSPathogens "Our findings ...underscore the urgent ned to develop broader-protecting universal sarbecovirus vaccines" https://t.co/oRRfPOrn4A
2022-09-22 16:59:00 RT @firefoxx66: What should we expect from #SARSCoV2 this autumn?I think it would be smart to prepare for both an increase in #COVID19 du…
2022-09-22 16:08:02 Some context:—77% White males (Veteran population), so generalizability—<
2022-09-22 15:05:02 Here's the breakdown by risk of outcome and excess burden per 1,000 people https://t.co/rwCEybLbk5
2022-09-22 15:03:08 @NatureMedicine Comprehensive analysis of #LongCovid neurologic outcomes at 1 year from >
2022-09-22 14:11:19 Congratulations @demishassabis @DeepMind for being awarded the Breakthrough Prize today #AlphaFold #AIhttps://t.co/kZSwCaOWwc"Few discoveries so dramatically alter a field, so rapidly” --@MoAlQuraishi
2022-09-22 14:00:12 The true pandemic death toll is currently ~22 million, not the official 6.5 million https://t.co/57lVnlqOPIMarked variance in official vs excess mortality between countries https://t.co/iCyz9XSYlU
2022-09-22 13:35:30 New neutralizing antibody data for BA.1 and BA.5 boosters, monovalent or bivalent, in micehttps://t.co/xlSWTEh6st @BioNTech_Group BA.5 better than BA.1 (for BA.5 counter)
2022-09-21 23:50:04 RT @thrasherxy: In its most lethal year, 1996, AIDS took about 1,100 lives in the United States each week. Last week, COVID took at least…
2022-09-21 22:45:55 Recovery >
2022-09-19 01:43:20 @meganranney Thanks Megan!
2022-09-19 01:02:26 Or that only 1 of 3 Americans have had any booster shot. A proclamation "it's over" is not going to help that https://t.co/oSnWZYX75g
2022-09-19 01:02:25 And what about the 400-500 Americans dying each day since April https://t.co/LduqLo6Iu2
2022-09-19 00:38:26 Wish this was true. What's over is @POTUS's and our government's will to get ahead of it, with magical thinking on the new bivalent boosters. Ignores #LongCovid, inevitability of new variants, and our current incapability for blocking infections and transmission https://t.co/sZyChorhC9
2022-09-19 00:28:03 @TheLizArmy Much appreciated and fully identify with you
2022-09-19 00:00:32 @terrawellington Great question. We need to push our government hard to invest in more durable and effective, variant-proof nasal sprays and shots. Instead of wasting $ billions on >
2022-09-18 18:14:51 For now: get a booster. It's the best shot you have to stay maximally protected (unless you had BA.5). It's worth the early side-effectsFor the future: we need a better strategy that prevents infections, transmission (ergo #LongCovid) and is far more durable, variant-proof
2022-09-18 18:14:50 12. There are no data to show durability of boosters vs severe Covid beyond 4-6 months. Or to even show that the new (? more potent) bivalent Omicron BA.5 will perform better than original or BA.1 bivalent boosters. A ≥ 2-time booster strategy per year is untenable, long term.
2022-09-18 18:14:48 10. Is this because Omicron BA.1 is less immunogenic or because of imprinting (responding preferentially to 1st exposure strain)?Same pattern of reduced antibody response in mice (and humans) to BA.1 and BA.5 compared with ancestral https://t.co/OLJCIWdldP
2022-09-18 18:14:46 9. Let's zoom in further on these data (here's the fog part)The antibody response to Omicron BA.1 (geometric mean titer) was multi-fold less than against the ancestral strain for the bivalent or original booster https://t.co/15WrhxFGA6
2022-09-18 18:14:44 8. Yet the overall data to support the need for boosters is clearcut. What about the bivalent Omicron vaccine that matches up to BA.5 (and BA.4.6) that account for ~99% of American cases?The data for a BA.1 bivalent vaccine was published @NEJM 16 Sept https://t.co/3ZJXrOchHh
2022-09-18 18:14:43 7. More on lack of enthusiasm for new bivalent Omicron boosters (actual data to be released this week)https://t.co/cgfn3roAhb @NPR by @nprscottsimon @robsteinnews https://t.co/Vo6yJucG8K
2022-09-18 18:14:42 6. Today's NY Times front page https://t.co/cJOWj5pIzEby @jackhealyNYT @sharonNYT @amyyqin Reasons: lack of perceived benefit, reactogenecity side-effects, unaware, "it's over"I'll come back to "potent" subsequently https://t.co/tWjakyDUYi
2022-09-18 18:14:38 4. There is also evidence that boosters help protect vs #LongCovid (point estimate 84% reduction for 3 shots in this cohort of health care workers)https://t.co/IAuQCZs6blhttps://t.co/T33YZHq1VD
2022-09-18 18:14:36 3. The magnitude of benefit has been consistent over time, for different Omicron subvariants. Here in May, across all ages, H/T @redouad, 96% reduction of death for 4 shots vs unvaccinated https://t.co/oetnzuCikH
2022-09-18 18:14:34 2. The most recent @CDCgov data, compared with unvaccinated, age 50+4 shots: 94% reduction of death3 shots: 83.5% reduction of death https://t.co/ZXvVOKOhEb
2022-09-18 18:14:33 Lifting the booster fogThe evidence supporting boosters is incontrovertible. Summary of data for 4th vs 3rd shots for survival benefit, age 50+The unequivocal benefit is for enhanced protection vs severe Covid https://t.co/2Gpaxq8xlM
2022-09-18 15:19:13 @CarlHoefer1 @AlpertReyes @a1daylanan @mtosterholm Read the article
2022-09-17 20:49:26 This IS good news and aligns well with many prior report vaccination-mediated reduction (≥40%) of #LongCovid But to *prevent* this we need to block infections and transmission. As the virus evolved, that's unlikely to come from shotshttps://t.co/HqzfKW3JCkhttps://t.co/JiEAqC08T2https://t.co/JUvJnk6ucm
2022-09-17 19:01:25 When hallucinating can be a good thing......"Our results highlight the rich diversity of new protein structures that can be generated using deep learning"https://t.co/085N9nDqFd @ScienceMagazine @UWproteindesign @BasileWicky #ProteinMPNN #AlphaFold #AI https://t.co/aVQe1uqeVN
2022-09-17 18:11:10 It’s “a landmark study in the treatment of autoimmunity” —Aimee Payne @PennMedicine https://t.co/QKkstwc7AL @ScienceMagazine @jcouzin
2022-09-17 17:06:26 This thread is rich with new insights about imprinting in response to BA.5 breakthrough infections (relative lack of nAb response), and for the BA.2.75.2 variant pinpointing the mutations that help explain its immune escape https://t.co/SzcTYViNKNhttps://t.co/0oUIdbJIlZ
2022-09-17 15:13:10 Here's the preprint by @BenjMurrell and colleagues now posted, summarized in his threadhttps://t.co/6kuQCL8AJs"BA.2.75.2 was neutralised...five-fold less potently than BA.5... These data raise concerns that BA.2.75.2 may effectively evade humoral immunity in the population."
2022-09-17 03:31:35 @MikeMadden Not to worry. It would take a couple of months for this one or an alternative to become dominant, even with exponential growth
2022-09-16 20:17:10 This is one of the main BA.2 new variants to be concerned about, with real immune-evasive potential to outcompete BA.5 https://t.co/nE5OdNBYsl
2022-09-16 20:11:07 @BenjMurrell I'm with you on this, Ben. Very concerned about BA.2.75.2
2022-09-16 18:41:26 "if just 5% ultimately fulfill criteria for #LongCovid, that means 7.5 M individuals would be affected in the US. In comparison, each year in the US, ~1.8 M individuals are diagnosed w/cancer and 1.5 M are diagnosed w/ diabetes."https://t.co/SrtRtGsYCD@Health_Affairs https://t.co/fww1YTcF6o
2022-09-16 16:40:20 BF.7 is BA.5.2.1.XBA.2.75 (spike mutations below, H/T @PeacockFlu ) isn't as concerning as further BA.2 derivatives BA.2.75.2 acquired 3 more key spike mutations, more immune evasion potentialNB: The virus is still showing substantial signs of evolution
2022-09-16 16:24:54 The latest US genomic surveillance data shows another small gain of BA.4.6 but, for the 1st time, past the 1% threshold of BA.2.75 and BF.7https://t.co/jjl2AnOYb5https://t.co/HzwoPmIyre
2022-09-16 16:06:15 No differences in reactogenicity/safety between original and bivalent Omicron booster(this is an issue which needs to improve and discourages people from getting booster shots) https://t.co/vRFcIC3G18
2022-09-16 16:02:39 Just out @NEJM The bivalent ancestral/BA.1 Moderna vaccine as a 2nd booster vs original boosterhttps://t.co/tlZQSJaTTi~2-fold increase of neutralizing antibodies vs BA.1, BA.5, no effectiveness data https://t.co/FqHikImL19
2022-09-16 13:50:25 It's exciting to see the powerful impact of CRISPR genome editing "In the low-dose group, the one-time infusion also reduced by 91% the painful swelling “attacks” commonly experienced by patients with a rare condition called hereditary angioedema"https://t.co/SfC6squo9Ghttps://t.co/Qxl1kwVd56
2022-09-13 03:11:04 I posted an addendum to clarify misinterpretations that I have undervalued the profound contributions of human genomics.
2022-09-12 22:55:39 A Covid shot prime and nasal vaccine boost significantly reduced upper airway viral load and transmission in an experimental model, w/ perspective on other shot plus nasal vax booster clinical successhttps://t.co/wpaudojNbP @SSI_dk @GKPedersen @eBioMedicine https://t.co/lAsigX4DdX
2022-09-12 22:34:35 The protection derived from a 4th shot mRNA booster in ~40,000 people age 80+ in Singapore, compared w/ ~40,000 matched controls with 3 shots, during its BA.2 and BA.5 waveshttps://t.co/mHohjlT2lx @AnnalsofIM https://t.co/t6kpxAwnZp
2022-09-12 21:23:07 The road to cancer cures may go through the nervous system. An astute perspective on cancer-neuroscience interactions @NatureCellBio https://t.co/T4wEDD0O9B by @ChenchenPan1 @Winkler_Lab https://t.co/AGKX3CQP0z
2022-09-12 19:59:36 The paper was mistakenly put behind a paywall, which has now been corrected. Here's the link https://t.co/rYT7Hsf2jH
2022-09-12 18:17:03 A 2nd paper today with more results from this cohort on physical activity and cadence, specifically for association with cardiovascular and cancer events during follow-uphttps://t.co/qPenxKQoSO @JAMAInternalMed https://t.co/KElFmqRyga
2022-09-12 17:52:24 RT @DKThomp: This is really exciting: I'm talking to @EricTopol tomorrow afternoon in a live interview about the future of medical innova…
2022-09-12 16:11:13 A new and outstanding review of Covid/#SARSCoV2 in immunocompromised individuals https://t.co/51TMhVW1Kd @ImmunityCP @dewolf_susan @SantoshVardhana @MSKCancerCenter https://t.co/1UBQ9BzLiH
2022-09-12 15:45:49 From combining genetic data in over 730,000 people and 80 diseases burden estimates:"Genetic risk factors can explain a sizable number of healthy life years lost both at the individual and population level"https://t.co/ggljmkcmHG @NatureMed @andganna @DrSakari @FIMM_UH https://t.co/rUI1Ua3mIP
2022-09-12 00:57:50 RT @McFaul: Ukrainian warriors are humiliating Putin and his generals.
2022-09-12 00:40:00 The chasm between knowledge and practice needs to be addressed https://t.co/SU49gPt8RZ
2022-09-12 00:02:30 RT @mor10: "COVID is over" they say as the pandemic burns through the population making people sick, giving people chronic illness, killing…
2022-09-11 20:18:41 More than 20 years after the 1st human genome was sequenced, there's relatively little to show for it in clinical practice. https://t.co/NmbW8oqtLc
2022-09-11 17:14:28 I don't think so:"In a not-too-distant future, your Prime membership may include a free annual checkup."https://t.co/5Q8JeqlYPp by @david_wainer https://t.co/dOMwe7Fxgr
2022-09-11 15:39:35 "The U.S. shouldn’t live with covid. It should get beyond the virus."https://t.co/u0USbACt9aOn annual shots working: "that is a massive if""The nation needs a massive push to create a universal coronavirus vaccine against all variants and for a long duration." https://t.co/5ABsPsdhoO
2022-09-11 15:19:18 The first organ transplant in the US was in 1954.Now there have been 1 million.105,000 people are on the waiting list.~17 die each day waitinghttps://t.co/5luRM9owWJ by @LNeergaard @APHealthScience https://t.co/zhMZXLJzoR
2022-09-10 22:40:42 "These findings highlight the need to develop vaccines that enhance nasal immunity."https://t.co/MkDNgpb6HT @FelicityLiew @p_openshaw @LanceTurtle @InThwaiteImmune and colleagues https://t.co/CXVvcVF3Yo
2022-09-10 19:28:25 RT @EricTopol: We'd never met someone w/ degrees in math, physics, history (2), and expertise in health data scienceProf Christina Pagel @…
2022-09-10 18:53:42 Superior antibody vs variants of concern and T-cell response for nasal vaccine (i.n.) compared with shots (s.c.)https://t.co/YmX3XHML6y @StJohnLab @dukenus @justsaysinmice https://t.co/VThK88lwSS
2022-09-09 19:55:05 Does when you load calories during the day help with weight loss? A randomized, crossover trial says no https://t.co/pUJPMk7FUF @Cell_Metabolism https://t.co/bDmqe3f2iX
2022-09-09 19:23:06 We'd never met someone w/ degrees in math, physics, history (2), and expertise in health data scienceProf Christina Pagel @chrischirp is a leading information &
2022-09-09 18:38:30 Latest US #SARSCoV2 genomic surveillance: 89% BA.5, 9% BA.4.6Slow growth of the latter, ~1%/week, and overall decline in cases No other variants at appreciable levels https://t.co/cVICaeqetJ
2022-09-09 17:49:01 RT @chrischirp: Delighted to chat to @EricTopol and @cuttingforstone at length about maths, physics, history, my day job - and mostly - Cov…
2022-09-09 14:39:52 Hey, U.S., is this the best you can do?“At this point, we know another variant is coming — we just don’t know when,” a senior administration official said. “Our job is to make [the vaccine] available. And then people can do what they want.”https://t.co/1dK0FAoEUJ@adamcancryn
2022-09-09 14:14:49 The comprehensive list of validated treatments for ME/CFS and #LongCovid.This has to change. https://t.co/qW2wMapwVq
2022-09-09 14:03:33 In this thread, @chrischirp provides a useful summary of the responses for each of the 6 salient topicshttps://t.co/NbESV9XOIG
2022-09-08 22:38:50 RT @ProfPCDoherty: It's important not to 'push through' with high level fitness activities if you've had mild COVID and, months later, your…
2022-09-08 19:12:37 As opposed to what is generally thought (from under-reporting sequence variation of Covid samples)......"Our study has revealed significant within host infection diversity of #SARSCoV2 through full genome sequence analysis."https://t.co/22Ab1H4dl0 @PLOSGenetics https://t.co/mErDXuNoCZ
2022-09-08 18:24:57 Quite the @ScienceMagazine feature on Covid and children with key questions and insightshttps://t.co/OpTu7vWJlG@AldertonBiol w/ @chrischirp @dgurdasani1 @BinitaKane @carlpierce @PeterHotez @sarahcobey @scotthensley https://t.co/JpDwJTqRM8
2022-09-08 18:07:06 Excellent, succinct review of myalgic encephalomyelitis (ME/CFS) and its overlapping features with #LongCovid @ScienceMagazine https://t.co/CipzsAdv2rhttps://t.co/nSAfeCU9eL
2022-09-08 16:43:49 Missed opportunities in the U.S. The intellectual property for multiple Covid nasal vaccines was licensed to companies in other countries, such as that of @WUSTLmed to @BharatBiotech https://t.co/YrV9ojPWpHhttps://t.co/clrbrUUDiQ
2022-09-07 23:00:36 More on the risk of artificial sweeteners ascertained through a large (>
2022-09-07 22:10:07 2 more reports characterizing BA.2.75https://t.co/0Q16FPfXw4 @cellhostmicrobe https://t.co/jt1p9uuLUv @NEJM But the concern is now shifted to BA.2.75.2, which has acquired 3 more key spike mutations, more immune evasion, see @PeacockFlu &
2022-09-07 21:44:34 @JaneEspenson @NEJM Yes, for sure, in high-risk people. There is no question of Paxlovid's high efficacy—protection vs hospitalizations and deaths—despite the occurrence of rebound in some (per cent still unknown) people
2022-09-07 21:19:47 How well does an original (ancestral strain) mRNA booster hold up vs BA.5 over time for neutralizing antibodies?https://t.co/W00tJM8bZW @NEJMNot well, especially in people without breakthrough or prior infections https://t.co/S08OQzpRSJ
2022-09-07 21:11:56 A small, in-depth study of Paxlovid rebound demonstrates high viral load with symptoms or positive antigen tests—which supports infectiousness— along with occurrence in 5 of 13 families, suggesting it is not uncommonhttps://t.co/Zqz8kaZpT4 @NEJM https://t.co/ot8yVTTu3G
2022-09-07 13:50:27 A new report confirms BA.4.6's (now ~10% in US) immune escape, loss of Evusheld sensitivity"The loss of activity of tixagevimab and cilgavimab against BA.4.6 leaves us with bebtelovimab as the only therapeutic mAb that has retained potent activity"https://t.co/6zIY01Fi0whttps://t.co/pJE1BfaHnWhttps://t.co/IJ2RkH1Eow
2022-09-07 13:31:53 @yunlong_cao @CorneliusRoemer @chrischirp @TheLancetInfDis @BenjMurrell @PeacockFlu @DannySheward Quite concerning. Look forward to reviewing the data Thank you
2022-09-07 02:25:34 What is the prevalence of #LongCovid with the BA.5 variant? A new report from US, June-July, w/o controls, is the first crack at the question: 21.5% had symptoms >
2022-09-06 22:39:03 More good news on BA.2.75, replicating and extending the prior (attached) reporthttps://t.co/duCTPI7c5s"antibody escape is an overall less pronounced characteristic of BA.2.75 compared with BA.4/5"@TheLancetInfDis https://t.co/9SszCrYNkB
2022-09-06 22:21:21 @FlyingFish06 @GradyMcGregor @cansinobio_inc It was there, now removed. The author, @GradyMcGregor, should respond
2022-09-06 21:59:32 @lexbyanyname @leozh @HMogan24 @scottshanno @loriand95467435 @lehudgins Yes, the lowest estimate was 15% reduction, from this reporthttps://t.co/2JUuTatett
2022-09-06 21:47:18 The U.S. hasn't really even tried https://t.co/OEhpuFFenL by @GradyMcGregor Meanwhile 1 breath of @cansinobio_inc's inhaled vaccine booster was better than a 3rd shot vs Omicron for neutralizing antibody response (92% vs 0%) at 4 weeks
2022-09-06 21:31:45 @CarlosdelRio7 on "boosting our way" out is untenable, but to give a false impression of year-long protection (vs severe disease and death) with the data in hand is not acceptable. There are multiple ways this can be achieved, and the US is not actively aggressively pursuing any of them.
2022-09-06 19:43:34 I've previously addressed the vital need for variant-proof &
2022-09-06 18:50:25 Just tweaking the lipid nanoparticles could make a big difference"There is still so much optimization and development that needs to happen"—@AnnaBlakney "There's a huge amount of RNA that's not being used"—@sahayg1https://t.co/Q3wiygjRcd by @ElieDolgin @ScienceMagazine https://t.co/3ZT4fOkNeo
2022-09-06 18:24:35 This has the ring of Covid capitulation https://t.co/9boHwQ6nYiI'm certain we can do better than this. The science foundation is there for multiple paths of extended durability and enhanced protection. The will is not. https://t.co/iBMu0mcqRa
2022-09-06 18:12:59 @Laurie_Garrett Agree, Laurie
2022-09-06 17:40:44 I don't see any evidence for how an annual Covid shot will provide durable protection (current ones wane after 4-6 months) without better vaccines, such as variant-proof, improved nanoparticles, and nasalhttps://t.co/uytgskKKN9https://t.co/knjhSjNELL
2022-09-06 16:51:28 Discovery of new antibiotics is critical to deal with the resistance issue. Hope this would be accelerated with the use of #AlphaFold is tempered by this new @EMBOPress report https://t.co/rydDsMeE6v by @MIT_IMES @MITdeptofBE https://t.co/BVqn1gh69n
2022-09-06 16:34:35 @HenrikVogt Wrong. You have completely misinterpreted and twisted what I wrote. I simply pointed out that the symptoms of the Yale/Mt. Sinai study participants tracked tightly with the multiple molecular biomarkers they assessed.
2022-09-06 15:05:31 The link between physical activity (steps) and avoidance of dementia A new @uk_biobank study of over 78,000 people showed largest decrease for >
2022-09-06 13:32:35 Nasal and oral vaccines are our best shot to block infections, transmission, achieve containment of the virus, reduce the toll of sickness, &
2022-09-05 16:47:04 RT @VirusesImmunity: Very happy to see that China approved the world’s first inhaled vaccine against COVID-19. Convidecia Air is an aerosol…
2022-09-05 16:43:38 First inhaled Covid vaccine approved, with improved Omicron antibody response as booster to 2 shots (Coronavac) compared to 3 shots https://t.co/3MtEgb7Rro by @GradyMcGregor
2022-09-05 16:22:25 @HoffmannJedrzej @NatureMedicine @v_puntmann @AShchendrygina @c_eike @AndreasZeiher @GoetheCVI Such an important study to help us understand cardiac implications and ties to symptoms during extended follow up in a selected cohort of mild Covid, with controls. Thanks to you and your colleagues
2022-09-05 15:27:18 The main symptom was difficulty breathing with exertion
2022-09-05 15:13:51 "The imaging findings suggest that inflammatory cardiac involvement after COVID may be a pathophysiological commonality shared among all individuals, regardless of the expression of cardiac symptoms" https://t.co/NuA9h9CXIL
2022-09-05 15:13:49 @NatureMedicine Heart manifestations of #LongCovidA prospective MRI study of 346 people with mild Covid, and controls, demonstrated myocardial inflammation at 3 months, worse w/ symptoms, and edema at ~1 yearby @v_puntmann and colleagues @GoetheCVI https://t.co/TjrAJphYChhttps://t.co/RxlRyHCcZ1
2022-09-04 19:54:22 Entry of #SARSCoV2, with viral membrane fusion and transfer of the genome to the cytosol of the cell. Requires an acidic pH (nasal pH in 17 healthy participants was 6.6)https://t.co/As5p6jg7JO@PNASNewshttps://t.co/7LoyTJyCf0
2022-09-04 18:18:08 Vaccine breakthrough infections teach us about the upper airway T-cell immune response, its durability, and hybrid immunity. Yet another indicator of what nasal vaccines could achieve instead of breakthrough infectionshttps://t.co/12cocEJ8MK @JExpMed by @bertoletti_lab https://t.co/XYkPrD9KA3
2022-09-04 00:45:15 @LongDesertTrain It's certainly possible, Ryan. Which is why I wrote "several" instead of "many" weeks respite and emphasized variant-chasing isn't the right strategy.There's also the BA.2.3 you've spotlightedhttps://t.co/ez2XHPwhPX
2022-09-03 19:29:07 The new bivalent boosters are already available in many drugstores around the country. The BA.5 spike protein mRNA comprises 15 μg for Pfizer and 25 μg for Moderna https://t.co/mf2Leop05q
2022-09-03 18:51:22 The new bivalent BA.5/ancestral booster may help restore that and could also improve protection vs infections and transmission. But we won't know that for several weeks /5https://t.co/BR54il19st
2022-09-03 18:51:21 What is concerning to me is to see the decline in vaccine effectiveness vs hospitalizations for BA.5 compared with the prior Omicron subvariants /4https://t.co/64b9g7HW1hhttps://t.co/7fzohLYZ7X
2022-09-03 18:51:20 Please be aware there's still lots of circulating virus, ~90% of which is BA.5 out thereOnly BA.4.6 is slowly competing at an appreciable level, recently ~1% growth/ weekLatest transmission map /3https://t.co/S0JGpwehtc. . https://t.co/v0bcuHFCZH
2022-09-03 18:51:18 The US metricsExcept for deaths that remain at a ~500 deaths/day plateau, all are pointing in the right directionCases are notoriously under-reported, but we are at the lowest level in 4 months, (that number of confirmed cases, 78K, is still very high) /2 https://t.co/BYmoS9p3IH
2022-09-03 18:51:17 The BA.5 variant wave is in descent in the US and throughout the world. Without a threatening new variant that exhibits ability to strongly compete now, we should have several weeks of a respite World cases/ deathsJapan, one of the last to get hit, still on the rise for deaths https://t.co/pq4fkpYEoF
2022-09-03 16:49:29 The involvement of endothelium, the lining of blood vessels, is an important underpinning of #LongCovid's pathophysiology. An impressive review paper @jclinicalinvesthttps://t.co/TYLx2ZsZZFhttps://t.co/w1OMf3Y2ah
2022-09-03 01:16:54 @CarlosdelRio7 Yes, Carlos, because it has no real competition. That may be good, and help us avoid a new wave for many weeks. I don't want to see a variant that can rapidly out-compete BA.5!
2022-09-02 20:57:18 Very good #LongCovid review of what's known on mechanism, sequelae and treatments. One edit from me on the title https://t.co/Rs6Filotob@PNASNews by @LeahabShafferWe urgently need to get treatments validated https://t.co/F5XvBrAIof
2022-09-02 18:44:06 One of the big biomedical advances this year was the report that multiple sclerosis is caused by the Epstein-Barr virus. A new essay @jclinicalinvest says not so fast, the strong evidence was restricted to one grouphttps://t.co/1xmbTJV1DV by @ihorwitz@Idasim and colleagues https://t.co/bO0LTBUyx6
2022-09-02 18:15:06 @AWeissmann_ Somehow "classified" and "empty folders" doesn't seem to go together very well
2022-09-02 17:27:56 "Our study demonstrates an unexpected role for GnRH [gonadotropin-releasing hormone] in olfactory &
2022-09-02 15:11:20 BA.4.6 (in blue) shows a lot of regional variation https://t.co/BjcE3uJrev
2022-09-02 15:11:18 Latest US genomic surveillance data posted shows BA.5 at 89%, BA 4.6 at 8.4% (slow growth) and no detection at appreciable levels of a new variant https://t.co/jjl2AnwOWXhttps://t.co/CNV3zZfjft
2022-09-02 14:41:29 To efficiently block Covid infections and transmission, we need to get high levels of secretory IgA, reflecting mucosal immunity. Important work by @florian_krammer and colleagues
2022-09-02 14:16:00 "Equivalent of a James Webb Space Telescope for biology," now predicting 3D structure of >
2022-09-02 01:57:48 An indefatigable force throughout the pandemic, @trishgreenhalgh goes deep to understand the big miss—that #COVIDisAirborne https://t.co/erqAF4iAiB@BMJ_latest w/ @DRTomlinsonEP and Mustafa Ozbilgin https://t.co/i5oX0kQw2Z
2022-09-01 23:06:56 Sone good news about the BA.2.75 variant, in case it gets legs: it's not more immune evasive than BA.5, has cross-immunity w/ BA.1/2, and is still sensitive to Evusheld and Bebtelovimabhttps://t.co/EgnyuWpCYm @TheLancetInfDis @BenjMurrell @PeacockFlu @DannySheward &
2022-09-01 17:30:08 Some slippage of vaccine protection vs BA.5 hospitalizations is concerning, reflects its immune escape, and there's hope for bolstering by the new boosters. As previously noted, it ought to prompt aggressive efforts for pan-sarbecovirus and nasal vaccineshttps://t.co/vwK1ZXsU7m
2022-09-01 17:01:20 Aligns with this @nature summary and perspective of a recent analysis by @DebCro @KirbyInstitute that suggests there may be little difference between the 2 bivalent vaccines (BA.1 v. BA.5) https://t.co/iqA2L2qPp7https://t.co/cejMclUDLu by @ewencallaway https://t.co/JW5uEcYvth
2022-09-01 16:18:26 Data also presented for protection vs BA.5 symptomatic infection for age 50+ (by booster dose and over time) https://t.co/lr1mzJulKq
2022-09-01 15:50:26 New data at today's CDC/ACIP meeting on vaccine effectiveness vs BA.5 wave hospitalizations, all adultshttps://t.co/64b9g7HW1hLess protection for both 3rd and 4th dose vaccines compared with the prior wave (BA.2, BA.2.12) https://t.co/JTichjw2I3
2022-09-01 15:36:55 And in mouse model challenged with BA.5 virus, similar impact for the 2 bivalent vaccines, better than original (ancestral) vaccine https://t.co/syanLPV1ni
2022-09-01 15:36:54 First look at BA.5 bivalent booster vaccine data from @moderna_tx, only in mice, at today's ACIP meetinghttps://t.co/8cZMlkWCmuNeutralizing antibody response similar to BA.1 bivalent vaccine https://t.co/g6KuRGt0pM
2022-09-01 01:59:32 RT @MaryPeltola: My position on the right to choose is simple: our government should not be in the business of telling people what they can…
2022-08-31 23:23:56 @pelagicbird @GretchenVogel1 @ScienceInsider @ScienceMagazine @lauriemcginley2 @washingtonpost @PostHealthSci Correct. I pointed that out too and still do not understand why we aren't going vs BA.5 only https://t.co/BR54il19st
2022-08-31 23:22:09 There's one country that doesn't get what it pays for, which preceded the pandemic https://t.co/7PaLGyglVTNow >
2022-08-31 22:36:50 Congratulations to @yuwang_15 for this groundbreaking workAnd the —seeing is believing—video https://t.co/W05gz13l7B
2022-08-31 22:29:56 Good to see for JapanStart of BA.5 wave descent for fatalities @OurWorldInData Japan has one of, if not the, lowest cumulative (and excess) mortality rates of large population countries in the world with rigorous tracking https://t.co/W1GR7Jdmtp
2022-08-31 22:09:12 @molly_knight @doctorsoumya @MommasGoneCity Thanks for sharing the horrible ordeal of what you're going through and so glad you're seeing some improvement. POTS is real as a #LongCovid serious sequelae, despite the denialism out there, and vaxx/boosters cannot be relied upon to protect
2022-08-31 21:27:32 A new, very good Covid vaccine review article @NEJM https://t.co/xglkQ5HQCO by @BarouchLab "Current Covid-19 vaccines are less effective at blocking infection with the omicron variant than ... prior variants, but protection against severe disease remains largely preserved." https://t.co/APj8UwoK6f
2022-08-31 21:01:28 Full text and table from supplemental for context https://t.co/tMVa93K8ga
2022-08-31 21:01:26 A Portugal nationwide study shows prior infections with BA.1 and BA.2 protects better vs BA.5 than earlier major variants, in a highly vaccinated population https://t.co/JuxIzrDZIFThat's good since previous data was unclear for BA.1/2 and there were a lot of these infections https://t.co/bfzrI5sk8B
2022-08-31 16:39:42 How fat tissue talks to the brainThe dogma was it occurred slowly through hormones. Now there's proof it occurs rapidly through neurons.https://t.co/Uh1c3L1rWtby my colleagues @scrippsresearch @liye_tsri@ardemp @Nature https://t.co/RDw6l8xeLf
2022-08-31 16:19:18 @Nature On autoimmune features of #LongCovid "..autoreactivity persists in a subset of patients w/post-acute sequelae, raising important questions...emerging autoreactivity to ongoing symptomology upon recovery"https://t.co/xyGIqRQYrkExtrapolated via patients w/severe Covid https://t.co/Hv43gMERvC
2022-08-31 16:03:13 Relevant to new BA.5 boosters for people with recent infection <
2022-08-31 12:50:05 The historic drop in US life expectancyBiggest two-year decline —2.7 years in total — in almost 100 yearsNow 76.1, the lowest in 25 years Levels at 1944 for AIANPandemic, accidents and overdoses were 1° drivershttps://t.co/0Z9TQIIXRwhttps://t.co/3iFlziN2Xkhttps://t.co/relDFO7Xhb
2022-08-31 03:52:05 @kyledcheney a picture worth a thousand(s) of [secret] words
2022-08-31 00:01:16 @CatchTheBaby @StephenAtHome Thanks Ruth Ann! Not sure how I goofed to get the link wrong
2022-08-30 23:47:49 RT @JusDayDa: @EricTopol @OurWorldInData Last 12 months... https://t.co/rk4bWpb7pU
2022-08-30 21:41:50 A colleague just sent me this video segment I did with @StephenAtHome from nearly a decade ago. It brought back some fun and funny memories https://t.co/Dc0gRFET3B
2022-08-30 20:03:18 Pandemic mortality over the past 12 months, outliers, per capitaOnly Greece and Hong Kong fared worse than the United StatesJapan (even w/ BA.5 wave that has doubled cumulative deaths), UAE, Qatar are among the lowest fatality ratesvia @OurWorldInData https://t.co/U2gtBX8H98https://t.co/hJJf9EpwGw
2022-08-30 18:35:47 The term "accessory genes mutations" is used to denote those outside of the spike"We interpret these data as suggesting that mutations outside of spike may be driving critical phenotypes of #SARSCoV2 infection and disease"Nice work by @mcgrath_marisa @MattFrieman and colleagues
2022-08-30 18:35:46 The spike-centric thinking of #SARSCoV2 does not take into account pathogenic mutations outside the spikeA report documenting potential importance of ORF3a/b and ORF8 in vivo, known to affect our innate immune response (IFN, 1st line of defense)https://t.co/d0xXiXGzBI@PNASNewshttps://t.co/X4f0MoftDp
2022-08-30 17:10:41 Good to see steady, albeit slow decline in US Covid hospitalizations, now less than 37,000But still nearly 3-fold that of April 2022's lowest point (metric definition hasn't changed) which should be attainable, at the leasthttps://t.co/7N96LQP0Dmhttps://t.co/im2u98ovUI
2022-08-30 13:53:42 On the after-effects of Covid, beyond and including #LongCovid"Covid generated a kind of epidemiological aftershock by leaving people susceptible to a huge range of other conditions"https://t.co/Tr9eFjnovw @FT by @SarahNev @federicacocco https://t.co/S2JNYobrhL
2022-08-28 15:39:31 This headline will not induce public confidence in the BA.5 boosters, with 175 million doses purchased https://t.co/v68wV79fVQIt may well turn out to be the right call, but there are many uncertainties, superimposed on poor US booster uptake, discussed https://t.co/BR54il19sthttps://t.co/rJvS1gYi69
2022-08-28 14:42:35 On the need for physician validation and empathy https://t.co/qIAunN252B
2022-08-28 14:42:33 The brain and #LongCovid https://t.co/kRS3MLXK5F a 5 summary by @WesElyMD Evidence/paths ->
2022-08-27 18:40:41 Using RNA sequencing from tissue biopsy and #AI to discover, validate, and quantify Covid vascular inflammation (called C19-RS) from CT scans, linked with clotting and adverse prognosishttps://t.co/xJIaDGseKm @LancetDigitalH @escardio #esc2022 https://t.co/QL7Qf53KQ4
2022-08-27 18:23:20 If you're a man 65 to 74 years old, should you have cardiovascular screening including a CT scan calcium score, ankle-brachial index, AF, blood tests for LDL and diabetes?A large randomized trial with 5.6 year follow-up showed lack of benefithttps://t.co/HFMXfyeN8c @escardio https://t.co/2jOgxOLAnQ
2022-08-27 17:28:39 Relevant statements from the reports of these 2 trials https://t.co/fcZn7G56tx
2022-08-27 17:28:37 No.Ad in @NYTmag for a dietary supplement (Urolithin A) that costs $200/month and claims to be "clinically proven to renew mitochondria"2 small clinical trials cited, called ENERGIZE and ATLAS, conducted by the companyhttps://t.co/I10jupjXYQhttps://t.co/zzWJnGgAs8https://t.co/8Hhmv33XBz
2022-08-27 16:30:19 Wrist sensors can help in early diagnosis of Covid/viral illness and may also be useful in managing #LongCovid, @TheLancet with @julialmv @ScrippsRTI and @RobertHirten @IcahnMountSinai https://t.co/KUhmHg3U28https://t.co/MMIftkHcwo
2022-08-26 19:35:38 @AstroKatie Agree, Katie. It's unpredictable. But I wouldn't have expected these findings in 20-year-old healthy soldiershttps://t.co/Z9WNhhNuJj
2022-08-26 19:19:47 While it isn't large, this is one of the most comprehensive #LongCovid prospective, w/controls studies yet. Not assessing mechanistic data (like immune response, persistent virus) but insights about enduring multi-system sequelae in a cohort that would be considered very low risk
2022-08-26 18:56:44 A prospective study of #LongCovid in young (median age=21), healthy, males (93%), with controls: "new evidence that even infections in young adults can lead to sequelae that persist several months"https://t.co/379fy4HmMWhttps://t.co/mp8METJrE6
2022-08-26 18:01:33 If you're into the impact of circadian rhythm and sleep on health, you'll find this new review @NatureRevGenet quite informative https://t.co/7avEroBCA4by @jlane_boston @SusanRedline and colleagues @BrighamWomens @broadinstitute https://t.co/4i560J0JPi
2022-08-26 16:26:25 This week's US genomic surveillance update BA.4.6 growth competing vs BA.5, slowly, most pronounced in one region (7)No other new variants at appreciable levelshttps://t.co/jjl2AnwOWXhttps://t.co/4O66l736Ld
2022-08-26 15:45:31 @SKDitta Much appreciated!
2022-08-26 15:29:49 Vaccines and boosters during the Omicron wave in Singapore, among >
2022-08-26 15:07:15 Consistent w/ the idea that "vaccine absolutism" (term from @SaskiaPopescu) won't cut itIn https://t.co/aGyvgFdoRO by @KatherineJWu
2022-08-26 15:02:22 "Most importantly, we need to achieve containment of the virus once and for all, and should not rely only on just the BA.5 booster." https://t.co/BR54il19st
2022-08-26 13:46:05 RT @Aiims1742: Nicely done! #OpenAccess in @NatureCancer:Cancer vaccines: the next immunotherapy frontierhttps://t.co/an3fahkaPE https://…
2022-08-25 22:55:16 "COVID-19 sequelae: can long-term effects be predicted?"No. That's the problem. #LongCovid cannot be predicted.https://t.co/eEy4EbtGqo @TheLancetInfDis
2022-08-25 21:52:49 RT @HandNF: "It’s actually striking that in 2 months from the June 28th FDA meeting, there is a BA.5 vaccine booster made at scale. That is…
2022-08-25 19:02:17 If you look at the spike mutation map for BA.5 and compare it to Alpha, the first major variant, it's striking how well vaccines have held up vs severe disease, and not surprising why it has been harder to suppress infections and spreadhttps://t.co/BR54il19sthttps://t.co/NMKx7mWadd
2022-08-25 15:58:31 Gene therapies, the potentially curative "miracles of medicine," are hitting stride with 40-50 expected to be approved by 2030. But their up front costs remains a formidable challenge, despite favorable cost-benefit analyseshttps://t.co/tcT4bBLOaNhttps://t.co/p9GUXhQxen
2022-08-25 14:50:50 Pre-bunking to fight against misinformation. Validation via 6 randomized trials using scalable videoshttps://t.co/B2cVrGHjHQ by @ScienceAdvances @roozenbot @Sander_vdLinden @_BGoldberg@steverathje2 @STWorghttps://t.co/cyMNJrik47 @nicoagrant @tiffkhsu https://t.co/TG6h3hX2IQ
2022-08-24 23:37:16 RT @PeterHotez: Pretty important thread from @EricTopol my take: despite the rebound, unpleasant minor side effects (metallic aftertaste+ s…
2022-08-24 22:53:39 Also published today, during the BA.2 wave in Hong Kong, among hospitalized patients without need for oxygen supplementation, early Paxlovid use associated with a 66% reduction of death compared with matched controlshttps://t.co/I8pG2RIFm8 and reduction ~50% with Molnupiravir https://t.co/3yimLea69Z
2022-08-24 22:32:50 @davidakin Thank you!
2022-08-24 22:24:58 @mdhhsu read the post to find out
2022-08-20 02:26:35 New CDC data on Covid deaths, age 50+, posted today, vs unvaccinated2 boosters: 94% reduction of death1 booster: 83% reduction of deathhttps://t.co/HGyjNwCm0vCurrent 2 boosters in USage 50-64: 11%age 65+: 26% https://t.co/L7OVsysrmB
2022-08-20 00:51:06 RT @SciImmunology: A new Editorial by @EricTopol and @VirusesImmunity calls for an accelerated initiative for nasal vaccination against #SA…
2022-08-19 20:04:12 This accompanied original research by @Jie_Immunology @ImmunologyTang @UVAImmunology colleagues https://t.co/kbV1dEJOK6Robust sterilizing respiratory tract immunity (BAL) from a nasal booster vaccine in the murine model, not seen with shots in people, including vs Omicron BA.1 https://t.co/n3kBAv8qh4
2022-08-19 19:23:52 "We urgently need to achieve population-wide respiratory mucosa immunity" to break the chain of transmission of Covid and achieve containment of the virusOur Operation Nasal Vaccine essay published @SciImmunology today https://t.co/OujfFxvdS6 an honor to work w/@VirusesImmunity https://t.co/eBHW3dRLMI
2022-08-19 18:09:55 @andkg @robsteinnews @NPR @NPRHealth @Nature @heidiledford Let me be clear. BA.5 ≠ influenza. It will be the 1st vaccine to go out at scale in the US since the original. There are no data for nAbs to BA.5 vax in humansWe don't even know if it will provide better clinical protection. There is no rush. Such data can be obtained in weeks.
2022-08-19 14:20:21 A new review of the T cell immune response from Covid infections, vaccines, and combined effect (hybrid) https://t.co/jWgo1smo3M @Anto_Berto @bertoletti_lab @ImmunityCP https://t.co/mG65sipeGt
2022-08-19 02:54:45 This isn't what "Living With Covid" was intended to mean https://t.co/Q1UV8aJrfF
2022-08-19 01:41:44 A high-resolution study of length of mild Covid infectiousness with virus culture and viral RNA load2/3rd of cases shedding virus, still infectious at 5 days post-symptom onset
2022-08-18 20:16:21 US Covid hospitalizations are at a plateau ~40,000, which is ~4-fold where we were in April this year.Likewise, deaths are at ~500 each day, and confirmed cases still hover about 100,000 per day.This is not what containing the virus looks like. https://t.co/rh9ja8SKNK
2022-08-18 19:55:17 Full text here. One point I'm a bit at adds with:There has been some reduction of vaccine/booster protection from severe disease with variants, although it's still high (75-80%). Prior to Omicron and subvariants it was >
2022-08-18 19:06:34 RT @_Eric_Reinhart: My short piece this week builds on @EricTopol's 2019 essay in @NewYorker, and also what has been an unsurprisingly larg…
2022-08-18 18:01:25 A super summary on the pivotal role of T cell immunity in response to Covid vaccines @ScienceMagazine w/ @ScienceVisualsby @EJohnWherry and @BarouchLab https://t.co/GHng2HSEuLhttps://t.co/1CUt9KJUjl
2022-08-18 17:22:12 Only 30% of American children age 5 to 11 have thus far been vaccinated. A new @CDCMMWR of >
2022-08-18 15:26:08 The ability to take on #SARSCoV2 variants can be greatly facilitated by improving nanoparticles A superb review @NatureNano https://t.co/34JnqDMZ8cBut it's science advances sitting in labs, not getting done at large to get ahead of the virus https://t.co/ZzQ8LFJ7eu
2022-08-18 15:10:45 @TRyanGregory @_TheAncientOne_ @OurWorldInData Japan's management of the pandemic has been exemplary
2022-08-18 14:25:07 Japan's BA.5 wave deaths are now higher than any previous variant and still rising sharply @OurWorldInData https://t.co/2ZM3hEuN4t
2022-08-18 14:16:43 This would be a mistake"For the first time, the FDA is planning to base its decision about whether to authorize new boosters on studies involving mice instead of humans."https://t.co/T1NFucQdf7Public trust is essential before rolling out BA.5 boosters to millions of people
2022-08-18 00:46:53 The new study with longer follow-up of nearly 1.3 million people with Covid adds to the concerns and replication of these 2 brain imaging studies https://t.co/HJWtJWieWL
2022-08-17 22:35:09 Accompanying editorial @TheLancetPsych with good context @GlynLewis9 @drjprogers @ucl @UCLPsychiatry https://t.co/97NisoBsHq
2022-08-17 22:35:08 Main endpoint of increased risk and graphs showing timing over 2 years. Data from electronic health records, retrospective https://t.co/9bNlqJzUJo
2022-08-17 22:35:06 US data, lack of differences between variants (Alpha, Delta, Omicron) https://t.co/KmdPfaXj4h
2022-08-17 22:30:09 In 1.28 million people, up to 2 years after Covid, w/ matched controls: "The persisting increased risk of post-COVID cognitive deficit, dementia, psychotic disorders, and epilepsy or seizures" and "similar during the delta and omicron waves" #LongCovid https://t.co/FRyGDJ8pSdhttps://t.co/NuqJ5Fq0Kx
2022-08-17 21:03:07 A randomized, placebo-controlled trial of 3 different drugs for Covid—metformin, ivermectin, or fluvoxamine—all of which failed to benefit with respect to primary endpoint, possible metformin benefit for a 2° endpointby @BramanteCarolyn and colleagueshttps://t.co/37zFMRvq8Fhttps://t.co/ntmA0HBrvF
2022-08-17 19:59:22 Rapid waning of immune protection by BA.1/BA.2 infections (mostly breakthroughs) against BA.5 infectionshttps://t.co/9XTirVPDa2 15-day intervals (A->
2022-08-17 18:23:16 We went from sequence of #SARSCoV2 to highly effective vaccines in 10 months, which was unprecedented. But nearly 2 years later, we see no replication of such hyper-accelerated effort, despite remarkable advances in science Today @ScienceTM yet another https://t.co/aQCjw2Z30ohttps://t.co/BmbD7aDjWg
2022-08-17 16:46:09 "The nightlife setting was the driver of Covid-19 spread, while household and healthcare settings were in the lower course of transmission chains"New report tracking Covid spread in Tokyohttps://t.co/kb9XFOGBKPhttps://t.co/HnxwVgcsbK
2022-08-17 15:49:16 We learned how to image cells without labelling, preempting disruption or killing, via deep learning #AI. Now the ability to sequence RNA of single cells without killing them https://t.co/cNyJcH987A another meaning to slice of life @BartDeplancke @EPFL_en @WanzeChen https://t.co/tX7Malx3EB
2022-08-17 02:56:18 Another step towards a pan-sarbecovirus, variant-proof vaccine. There are now >
2022-08-17 02:23:12 A brief #LongCovid thread well worth the read, on @jcouzin's @ScienceMagazine coverage/context of the new and insightful mechanistic report https://t.co/4bbg3VD5yV
2022-08-16 18:40:22 More perspective on the important new #LongCovid work by @sneakyvirus1 @VirusesImmunity @PutrinoLab and their colleagues @ScienceMagazine by @jcouzin https://t.co/vnVUVUpnIo“We should be trying these [potential treatments] right now” https://t.co/jhUL1OeHJfhttps://t.co/ZOj4RPqVkd
2022-08-16 17:25:33 Adding to the suboptimal T cell response in seniors, new data from @OHSUNews and @UTSWImmuno on how the neutralizing (and non-neutralizing) antibody response to vaccination diminishes with agehttps://t.co/rBEFjm5Qxdhttps://t.co/fxzKk1KHB3
2022-08-16 17:00:26 "Even a single case of paralytic polio represents a public health emergency in the United States."https://t.co/1Qavun6No3 new @CDCMMWR "95% vaccination coverage is required to provide herd immunity"https://t.co/pksC3nzU2E @FT @JamieSmythF @caitlinsgilbert https://t.co/d04pt3eEpk
2022-08-16 16:20:55 RT @YouAreLobbyLud: This is an excellent article by @EricTopol. It eviscerates the @CDCgov, and rightly so. I cannot understand what they a…
2022-08-16 15:05:13 The risk of blood clots in hospitalized patients with Covid vs influenza was increased 60-90% within 90 days, for venous but not arterial thrombosishttps://t.co/wPHf18NYYB @JAMA_currentRetrospective, much smaller influenza cohort from 2018-2019 https://t.co/sClYHF0J6U
2022-08-15 22:02:48 RT @AnjKhem: "By steadfastly continuing to endorse this flawed CDC guidance, our public health agency has failed its namesake mission of co…
2022-08-15 17:15:42 RT @Kit_Yates_Maths: "The CDC position that we need to “live with Covid”, as espoused with its guidance, should be countered by exploiting…
2022-08-14 23:48:08 What I wrote about the @uk_biobank when it came out. The need for independent replication. That's what the new study provides.https://t.co/wySNMFcytY
2022-08-14 22:59:17 RT @Mike_Honey_: @EricTopol Thanks and I'm glad it was useful.Here's the full thread for more context - recent growth advantage is a heal…
2022-08-14 19:42:11 The formidable challenge of BA.5 doesn't detract from the outstanding containment of the virus and high adoption of vaccines in these countries, with a 6-11 fold reduction of cumulative mortality per capita compared with the United States@OurWorldInDatahttps://t.co/00wQpIlJ3T
2022-08-14 19:00:11 For the multitude of people who think mild cases of Covid are totally meaningless, these results would beg to differ. Yes, it's a short-term effect so far and may be partially reversed over time. Yes, likely to be less w/ current variants and vaccination. But denial doesn't work.
2022-08-14 17:29:35 The rise of BA.2.75 has been studied very carefully by @TWenseleers and its trajectory may vary considerably between countries. Or we could see a co-dominance pattern, something that hasn't occurred yet /9 https://t.co/myYGLCDDGg
2022-08-14 17:29:33 More on BA.2.75Unlike BA.4.6, more evasive to BA.5 breakthrough infectionsGrowth advantage tied to enhanced ACE2 bindingBebtelovimab and Evusheld predicted to still be effective No sig increase in hospitalizations in India /8https://t.co/T8iIzUGTvZhttps://t.co/B7RGir61Hc
2022-08-14 17:29:31 What do we know about BA.4.6's properties?https://t.co/E4QrGwV6BZSpike mutation R346T may be keyIt appears to have more immune evasion than BA.5, some cross-immunity w/ BA.5 breakthrough infections, not resistant to Bebtelovimab, but Evusheld may not protect as well /6
2022-08-14 17:29:30 And to avoid spike-centric thinking, the mutation differences extend well beyond the spike, such as in the nucleocapsid (N), envelope (E), or ORF7b /5 https://t.co/Ma6PsxIFf8
2022-08-14 17:29:28 In the US, BA.4.6 has a foothold accounting for 5% of new cases https://t.co/jjl2AnwOWX, newly updated.BA.4.6 has been steadily growing here since JuneIt is already at 13% in US Region 7 /3 https://t.co/s5UndyXda2
2022-08-14 17:29:26 While BA.2.75 is becoming dominant in India, out-competing BA.5, we're now seeing signs it can also compete with BA.4.6 in Australia, as posted by @Mike_Honey_ /2 https://t.co/r1sRc2YjJm
2022-08-14 17:29:25 What variant will take over for BA.5 in the United States and why does it matter?It's currently between a BA.4/5 vs BA.2 subvariant https://t.co/V1UsNSU6m7
2022-08-14 16:05:31 The @uscensusbureau data for #LongCovidSelf-reported, without controls, or pre-Covid baseline symptoms like the new Netherlands study (12% prevalence) https://t.co/nnZsWWa0jVBut, no matter how you look at it, it's affecting a substantial number of people https://t.co/10abaYrpJR
2022-08-14 14:20:10 RT @CrabbBrendan: Thanks again for this excellent summary @EricTopol. And while we search for 'cures', I can't stress enough your final con…
2022-08-13 16:25:04 @paulg The protective power of massive prior infection exposure (hitting majority of their populations) which also adds to vaccine protection with hybrid immunity (vs the whole virus plus enhanced vs spike).Explained in full herehttps://t.co/pQYFuqy954
2022-08-13 16:20:36 Previously it was @GeisingerHealth and @Regeneron. Now it's @MountSinaiNYC and @Regeneron. Large health systems with their electronic health data and genomic sequencing for potential of drug discovery, but also bioethical considerationshttps://t.co/0rScAFfaYc by @JoeKGoldstein https://t.co/wLkD7A9yie
2022-08-13 15:28:39 @calirunnerdoc Yes, evidence from multiple reportshttps://t.co/tatxeNskY9
2022-08-13 15:18:39 Many other countries, like the US, had major case surges uncoupled from deaths as a function of their immunity walls, particularly related to prior infections. Discussed here https://t.co/pQYFuqy954
2022-08-13 15:18:38 The BA.5 wave resulted in higher deaths than from any prior variant in Australia, New Zealand and soon to be the case in Japan. That's despite very high vaccination and booster rates, attributable to BA.5's extreme biologic properties of immune escape and transmissibility https://t.co/z9TxC6shTR
2022-08-13 15:01:50 In one week's time we learned more about #LongCovid that we had in months, including evidence for a potential biomarker. Yet we're still way behind where we need to be to help millions of people who are affected. https://t.co/IEMD9R3LtUhttps://t.co/ONWeuShJ1o
2022-08-13 14:25:57 Last evening, we discussed the new @CDCgov guidelines, purportedly a shift to "protect the vulnerable," but fail to do so on many counts https://t.co/lJeFXASFjs
2022-08-12 17:34:36 RT @Karl_Lauterbach: Hier noch einmal eine gute Übersicht der Studien, die ab 50 einen klaren Überlebensvorteil der 4. Impfung zeigen. Die…
2022-08-12 16:58:36 RT @profhelenward: Excellent summary of evidence from recent Long Covid studies. Suggests clusters, and possible mechanisms for some.Also…
2022-08-12 15:57:50 @manda_trkac @ImmunityCP @kieluni Agree! Not petty at all.
2022-08-12 15:47:43 @ImmunityCP On T cell response to vaccination in seniors"Our results reveal that an intrinsic defect of the CD4+ T cell repertoire causes the age-dependent decline of immune response quality against SARS-CoV-2"https://t.co/ensXlddJ3T @kieluni https://t.co/VnCZf2RkTn
2022-08-12 15:38:56 For context"The increase in maternal death during delivery hospitalization and pregnancy-related complications during the pandemic is alarming."@JAMANetworkOpen todayhttps://t.co/TOvbaiWeSB by @Rose_L_Molina @BIDMC_ObGyn @HarvardChanSPH @joefigs2 @harvardmed https://t.co/zpCCNfdTwR
2022-08-12 14:42:20 RT @pranavrajpurkar: Delighted to share our review on "Self-supervised learning in medicine and healthcare" in Nature Biomedical Engineerin…
2022-08-12 13:34:58 The US booster botch for even 3rd shots. All @OECD countries except US >
2022-08-12 13:34:57 Summary of data supporting survival benefit of a 4th shothttps://t.co/lMLDEgpQvL
2022-08-12 12:54:05 RT @sheencr: Really excellent summary from @EricTopol on #LongCovid latest data incl markers to identify patients (a role for cortisol) a…
2022-08-12 04:34:31 RT @uche_blackstock: The CDC is relaxing COVID guidelines and saying it’s because we have a high percentage of population immunity when onl…
2022-08-12 01:06:10 In the past week, there's been a flurry of new, informative reports on #LongCovid. I've tried to summarize them here along with the implicationshttps://t.co/IEMD9R3LtU (PS you can subscribe, it's free)
2022-08-12 00:11:21 This seems importantClassified documents relating to nuclear weapons were among the items FBI agents sought in a search of former president Donald Trump’s Florida residence ohttps://t.co/tclYL3Nbyh
2022-08-11 20:06:25 RT @EricTopol: Covid and the brainhttps://t.co/SIWJuCDidRJust published @PNASNews —cortical atrophy and cognitive dysfunction in 81 peop…
2022-08-11 19:40:09 Covid and the brainhttps://t.co/SIWJuCDidRJust published @PNASNews —cortical atrophy and cognitive dysfunction in 81 people with mild Covid vs matched controls (as seen in @uk_biobank study)—astrocyte infection in severe Covid, recapitulated by iPSCs https://t.co/p8Id5nzbO3
2022-08-11 19:26:49 Our CDC at work. This is embarrassing, to say the least. https://t.co/21IFipxDNl
2022-08-11 19:17:30 The 4th shot in Americans age 50+ 10% age 50-6425% age 65+The US now ranks 80th in the world for booster vaccines at 32% of populationhttps://t.co/gWCbSb6EfDhttps://t.co/SOtBwq1zCZ
2022-08-11 19:06:13 The @CDCgov doubles down on its flawed, not evidence based Covid recommendations with a new guidance document1. Leaves fully vaccinated = 2 shots, stay "up to date"2. Leaves isolation at 5 days w/o rapid tests3. Pushes "community levels" when real info is "transmission levels" https://t.co/Sflm8U0xbS
2022-08-11 17:13:50 The positivity rate of self rapid antigen tests tracked well with PCR throughout the United States Omicron and subvariant waves https://t.co/zNZYmyHZf6https://t.co/cOzT3bbDpc
2022-08-11 16:31:59 We've learned a lot this year about the underpinning of Epstein Barr virus in multiple sclerosis. The gut #microbiome is also important, as delineated in this excellent review https://t.co/11ly64ojsR @NatRevNeurol https://t.co/OLae2MFyeJ
2022-08-11 15:06:38 Until now, most #AI in medicine has involved large annotated datasets for inputs, known as supervised deep learning. Next up is self-supervised learning. @RayanKrishnan @pranavrajpurkar and I review this topic @natBME https://t.co/5Uyrc8rX4mhttps://t.co/81EhU0StVi
2022-08-11 02:00:53 There have now been >
2022-08-11 00:58:25 @_TheAncientOne_ @ewencallaway @Nature @yunlong_cao Yes, it would be good to hear from Yunlong on this contradiction
2022-08-10 23:53:08 BA.4.6 is currently the only other variant in the US besides BA.5 that has appreciable growth, at ~5% of cases, w/ its R346T mutation. A new study suggests:—Cross-immunity w/ BA.5 breakthrough infections—Bebtelovimab still potent, but Evusheld escapehttps://t.co/E4QrGwV6BZhttps://t.co/nJ2SofgG5b
2022-08-10 19:25:26 The low cortisol levels and ACTH in the #LongCovid group is especially intriguing, supports a dysfunctional hypothalamic-pituitary-adrenal axis, not so simple for steroid Rx. May help explain some symptoms and serve as a potential biomarker https://t.co/tT1wPBKZ9q
2022-08-10 18:18:10 My colleagues @scrippsresearch just published exciting work discovering broad neutralizing antibodies from macaques (with their structural biology) that could be used as a template for variant-proof Covid vaccineshttps://t.co/lbTuGRzWvh @andrabi_raiees @DennisRBurton @menz45 https://t.co/2rDWrAiYQ5
2022-08-10 17:30:57 Correction, typo: its striking BA.2 wave
2022-08-10 17:26:43 South Korea's BA.5 wave. Currently highest cases per capita in the world. Much less impact than (and an outgrowth from) its striking BA.1 wave.@OurWorldInDatahttps://t.co/ui1mrfJr4c
2022-08-10 16:56:14 An extraordinary high-resolution map of the heart after myocardial infarction, with spatially integrated single-cell gene expression and epigenomics https://t.co/P1L6bTDUdI@Nature @rkramann @KuppeChristoph @saezlab https://t.co/b9WIJtihd8
2022-08-10 15:42:45 New insights on the underpinnings and biomarkers for #LongCovid (LC) in a systematic study https://t.co/jFbxvhdOWP*Uniformly low cortisol level*, along w/antibody and T cell findings @VirusesImmunity @PutrinoLab HC-healthy controls, CC-convalesced w/o LC https://t.co/3IN7RckkdE
2022-08-10 15:11:41 @K_G_Andersen @NatRevImmunol @rahulsurya85 @TheOttLab Yes, I see your point for how the table is over-simplified and can be misleading. Their point on susceptibility to *infection* as a function of variant (not severe disease, yet not specified in the text) has some merit, consistent with what is being seen clinically
2022-08-10 14:45:55 If you thought we've seen the end of major #SARSCoV2 variants, think again https://t.co/DkiguWbGJ9
2022-08-10 14:29:54 The enhanced protection afforded by hybrid immunity (Covid infection plus vaccination) is influenced by variants https://t.co/ocjVAUDpZF @NatRevImmunol @rahulsurya85 @TheOttLab https://t.co/X7d4L6wAS8
2022-08-10 00:57:34 End of paper:"Consistent w/ this perspective, 70 investigators signed a letter to the FDA on April 21, 2022 encouraging the inclusion of T cell responses in addition to antibody titers for the evaluation of SARS-CoV-2 vaccines in humans"Letter (I signed)https://t.co/cvgOcvas96https://t.co/r1vB5joQjE
2022-08-10 00:51:36 And what happens if you deplete CD8+ (cytotoxic) T cells with a monoclonal antibody after vaccination + #SARSCoV2 infection?https://t.co/7wjpI8rILe @SciImmunology (macaque model) https://t.co/glworgmhVU
2022-08-09 22:22:37 Why are people age 50+ at higher risk of severe Covid?A new @PNASNews study indicates their significant narrowing of T cell diversity in response to infections may be part of the explanationhttps://t.co/vamn6sp8ughttps://t.co/kbtIfnMv0Y
2022-08-09 20:46:51 @calirunnerdoc @Nature @heidiledford I agree with this concern. Most, if not all, of the trials are small
2022-08-09 19:55:13 Important to emphasize this is a potential that has not been actualized clinically.But all the more reason to be prepared, accelerate efforts to have backup and combination oral anti-virals
2022-08-09 19:51:31 @JuliaRaifman For current virus, likely yesFor Mpro resistant mutations (*if* they become prevalent), hard to know
2022-08-09 19:08:08 @nlj @OurWorldInData No question! US has >
2022-08-09 17:53:48 Recognition for the 1st open-source Covid vaccine phenomenal contribution by @mebottazzi and @PeterHotez @FastCompany by @adambluestein https://t.co/V21apBgAvfhttps://t.co/n6AujxMikQ
2022-07-26 23:53:38 RT @EricTopol: A new BA.5 variant report from Portugal indicates higher rate of hospitalization (>
2022-07-26 19:47:48 BA.5 in AustraliaNew record of hospitalizations @covidbaseau Sharp rise in deaths @OurWorldInData https://t.co/PQYcZtmSOl
2022-07-26 18:58:08 RT @bhrenton: As today's White House summit starts in the next hour, a pertinent commentary by @EricTopol and @VirusesImmunity, who propose…
2022-07-26 17:32:30 The length of time of infectiousness of #SARSCoV2 https://t.co/IB2yW3wMjT"There is no data to support 5 days or anything shorter than ten days [of isolation]."Paxlovid rebound may extend that further
2022-07-26 15:57:11 "Hundreds of thousands of [Evusheld] doses sit on shelves in hospitals and infusion centers across the country" while the vast majority of 7 million immunocompromised Americans who would benefit are not getting this prevention https://t.co/LhL4WofyFF
2022-07-26 14:51:40 But despite this and demonstrated efficacy &
2022-07-26 14:51:39 Just out @ScienceTM The robust antibody immune response that an mRNA vaccine induces in children, including "highly preserved omicron-specific functional immunity"https://t.co/Qsa0fxdhwv @ragoninstitute https://t.co/n5iExIZlla
2022-07-26 14:30:00 The body of evidence for the protective benefit of masks, updated with multiple new studies, for community and health care settingshttps://t.co/1hsoxKYaNX @AnnalsofIM https://t.co/m6QWBWVbrp
2022-07-26 14:02:01 @backagainmaybe @mehdirhasan the graph was for Japan, and deaths are on the rise there https://t.co/Fa2nKoDykY
2022-07-26 13:48:42 The absolute rates of hospitalization are low, due to the immunity walls built in Portugal and Denmark (from vaccines, boosters, infections), but the increase with BA.5 reflects its higher virulence/pathogenicity
2022-07-26 00:44:26 RT @EdwardTufte: Brilliant and credible reporting of current situation. To reason about a pandemic requires pandemic data, a longer time…
2022-07-25 22:19:25 Here's the agenda for tomorrow's WH meeting on future of Covid vaccines. You can register here: https://t.co/1o8JKN1FdW I was asked to join the 2nd panel, but unable to make it. Great that @VirusesImmunity will be there. Let's gets nasal &
2022-07-25 21:15:11 if you don't have time to read the above @statnews piece, here's the gist https://t.co/kWrYthpweS
2022-07-22 15:19:04 Some reassuring new data for #LongCovid in kidshttps://t.co/6M7eDe0CaP Only "slightly higher" than the rates vs matched children without Covid, more seen in hospitalized and older kids @JAMANetworkOpen https://t.co/zZYQCjXHME
2022-07-22 14:26:26 Very good to see that the rare and potentially fatal Covid MIS-C in children (multi-system inflammatory syndrome) has markedly declined with Omicron, 95% less than Alpha https://t.co/6TcTFwBybn @deniseroland https://t.co/J9nSV55UGV
2022-07-22 14:16:24 Where the spread of the BA.5 variant has outpaced the prior BA.1 wave with nearly 200,000 cases yesterday https://t.co/bSW4QCF9Gp
2022-07-22 14:00:39 RT @ddiamond: White House has vowed to go “above and beyond” CDC guidance to care for Biden.“The fact they are overriding CDC recommendat…
2022-07-22 13:53:07 The prognosis is good, may take longer to fully resolve with BA.5. I also spoke to Kim about debunking the notion that vaccines "are not working." Yes, they're leaking re: infections, but they've already saved >
2022-07-22 13:06:05 RT @IforRWilliams: A clarion call from @EricTopol @VirusesImmunity in a new editorial:"As the virus continues its accelerated ability to e…
2022-07-22 04:39:10 @ShanLuLiu1 @SciImmunology @VirusesImmunity Such an important study and contribution from you and your colleagues. Back to you—thanks!
2022-07-22 02:51:18 RT @VirusesImmunity: I am thrilled to coauthor an editorial piece for @SciImmunology with @EricTopol highlighting the need for Operation Na…
2022-07-21 22:22:53 @TWenseleers After a few weeks looking at 2.75, your post was the first one I saw for any place outside India w/ growth advantage over BA.5 (despite detection in so many countries). There are mixed data out on its immune evasion. Agree it needs to be watched
2022-07-21 21:27:35 @TWenseleers Appreciate your points, Tom, w/ BA.2.75 data from countries w/ a BA.5 bkgd. My point on "scariants" (a word I coined) is that we needn't get carried away until we have clearcut + data, since so many have turned out to be false alarmsOthers feel similarlyhttps://t.co/yZgM8Bfk9Y
2022-07-21 20:02:47 RT @SciImmunology: “The prospect of achieving [containment of #SARSCoV2] with nasal vaccines is high, but will only be possible with dedica…
2022-07-21 19:03:53 We fully recognize the challenge of a successful nasal vaccine for high efficacy &
2022-07-21 18:57:42 That's "lightning speed" not lightened.There are now 12 nasal vaccines in clinical trials and 4 are far along, in Phase 3.But no plans for manufacturing at scale, distribution, accelerating. No government support. Yet a major unmet need
2022-07-21 18:27:50 It accompanies an elegant study in people &
2022-07-21 18:27:49 In today's @SciImmunology, @VirusesImmunity and I call for Operation Nasal Vaccine, the urgent need for a lightened speed initiative, to help block Covid infections and transmissionhttps://t.co/OujfFxMgU6https://t.co/a6bXX7sy01
2022-07-21 17:09:36 But the 65% increased risk of hospitalization for BA.5 is a source for significant concern, if replicated would point to higher pathogenicity and virulence for this variant
2022-07-21 17:01:39 "No evidence of decreased vaccine effectiveness against BA.5 compared to BA.2" (With most extensive genome sequencing to date to help differentiate variant effects)
2022-07-18 13:54:27 Not "Living with Covid" by the @bmj_latest Editorshttps://t.co/PettYwCGzk"How is the government responding to this crisis? Largely by pretending it is not happening or implying it is all under control."Seems familiar here https://t.co/89PKIs6UWw
2022-07-18 13:46:41 @matthewherper Thanks Matt. It was always a fishy story, too good to be true
2022-07-17 21:37:21 "But last week we got a reminder of other kinds of facts, the kind that bring us awe and comfort and context — even joy. The kinds of facts that prompt scientists to break down in tears."https://t.co/LYg2cwKQXh+ @sdutBreen :-) https://t.co/nl6N0BA9Ln
2022-07-17 19:28:23 @uhoelzle Yes, I do think more infections in the unvaccinated reference group is playing a role, reducing the VE gradient. But they're also frequent in vaccinated, which should bolster immunity. Paxlovid is now heavily being used, adding another confounding factor for hospital admits
2022-07-17 19:18:55 OTOH, hospital admissions are up more sharply in many countries that provide their data, overall well below BA.1 levels, for the same reason https://t.co/BNfkHN95PU
2022-07-17 18:57:29 The world and the BA.5 wave—2nd highest in confirmed cases after Omicron BA.1 with substantially less reported—Uptick in deaths, fortunately much lower than BA.1, due to population immunity wall of vaccines, boosters and infections@OurWorldInDatahttps://t.co/2i8uYgRcjU
2022-07-17 15:14:46 Boosters are essential to provide protection, but that may be slipping as the virus continues to evolve.Not encouraging.From >
2022-07-17 01:16:22 RT @debra_caplan: After successfully avoiding Covid for 2.5 years, my husband tested positive for Covid 3 weeks ago, cleared the infection,…
2022-07-16 21:17:55 @UrnovFyodor Thanks. Hope for a rapid and full recovery, Fyodor
2022-07-16 19:50:46 @SmoMichelle @StudBigg That's why I tried to simplify itHere is the Figure and the legend, p. 34And I previously wrote at length about this topichttps://t.co/vwK1ZXsU7mhttps://t.co/Ak879dwgoE
2022-07-16 19:40:24 @StudBigg there's a link if you are not too lazy to look at it and answer your question
2022-07-16 19:31:25 As the variant antigens drift further away from the ancestral #SARSCoV2, with more immune escape, growth advantage and fitness of the virus, the people drift off to sleep rather than taking initiativeAntigenic map adapted from https://t.co/VBDwVFH3Suhttps://t.co/0zo0AE8zwl
2022-07-15 23:26:28 Do the added mutations in BA.2.75 confer a different immune evasive pattern cf BA.5?Yes, at least that appears to be the case for Bebtelovimab, which has still shown efficacy for BA.5Other differences noted.https://t.co/Wf6uHNbGIW Mutation map at right by @PeacockFlu https://t.co/BTdGuT1B3v
2022-07-15 19:54:45 Acknowledging that the unvaccinated reference group is much more apt over time to include people w/ Covid infections. But so are the vaccinated, w/ hybrid immunity. IMO, there are multiple signs of VE attrition in this data set, particularly for BA.2 variants. No BA.5 data yet
2022-07-15 18:12:02 Recall that through the Delta variant w/ a 3rd shot booster, vaccine effectiveness vs hospitalizations was maintained ~95%
2022-07-15 17:46:40 This is quite telling about the slippage of protection of vaccines vs hospitalizations. With BA.2/BA.2.12.1 and 3 shots, in age 50+, vaccine effectiveness was only 55%.Restored to 80% w/ 4th shot Too much happy talk about vaccines providing great protection from severe disease https://t.co/5wOtxQU9Zf
2022-07-15 17:42:58 New CDC @CDCMMWR on Omicron variants (BA.1, BA.2, BA.2.12.1) Importance of booster to restore vaccine effectiveness improved after significant drop-off (Table), BA.2/BA.2.12.1 variants worse declineBenefit3rd shot all ages 18+4th shot age 50+https://t.co/nlB0B7A9R1https://t.co/LDP1Lus6Uz
2022-07-15 16:55:10 New: 2nd booster/4th shot broadening in the UK"people aged above 50, along w/ residents &
2022-07-15 16:36:59 RT @PeterHotez: At the risk of sounding like a broken record: maximize your boosters. Get your 2nd booster (4th immunization) if you are el…
2022-07-15 14:28:04 US Covid hospitalizations crossed 40,000 for first time since the end of February and slope of their ascent is increasinghttps://t.co/QPRo6jaOkahttps://t.co/oYIST9PYeL
2022-07-15 14:19:54 RT @EricTopol: Yet another study of improved survival with 4th dose of vaccine compared with 3rd, nationwide Sweden, here for age 80+https…
2022-07-14 23:21:35 Yet another study of improved survival with 4th dose of vaccine compared with 3rd, nationwide Sweden, here for age 80+https://t.co/tWMhxQdYxnhttps://t.co/jSKBxtK7Hi
2022-07-14 17:37:04 @saahilmenghani Hard to give strong recommendations without specific immunologic data but, in general, mixing (not matching) an adenovirus-vector or whole virus with an mRNA or protein--primary series/booster or vice versa--would be expected to induce broadest immune response
2022-07-14 17:14:52 @ScottGottliebMD Important qualifier. Thanks for noting
2022-07-14 17:11:46 Reassuring.There are no signs of spread of BA.2.75 ("Centaurus") in any other country besides India, a place with minimal BA.5 https://t.co/bQuxSTGGa9
2022-07-14 01:27:03 Full @pbsnewshour segment on the BA.5 variant, Paxlovid, action steps, with transcripthttps://t.co/grWLMlK8lK w/ @WmBrangham and @JudyWoodruff
2022-07-14 01:05:22 Latest review of incidence and natural history of myocarditis/pericarditis following Covid vaccination with 46 studies, >
2022-07-13 23:26:01 RT @NewsHour: The new BA.5 coronavirus variant is fueling yet another wave of COVID-19 infections. The CDC said it's now the dominant strai…
2022-07-13 21:52:30 RT @AliHMokdad: Agree with @EricTopol “They haven’t gotten across that two shots is totally inadequate,” they are not doing enough and not…
2022-07-13 16:03:48 How #SARSCoV2 infects/affects brain astrocyteshttps://t.co/bXKLN6GzCg @PNASNews by @Andrews_MG @tmturkee @TheOttolab @Kriegsteinlab and colleagues https://t.co/Tlk4PNMHp6
2022-07-13 15:16:59 @NateSilver538 @OurWorldInData New Zealand is a model country for how it managed the pandemic, including a high vaccination &
2022-07-13 15:03:52 @NateSilver538 @OurWorldInData Yes, that hasn't changed throughout the pandemic. The signal from small population countries can be difficult to interpret, but longitudinal assessment helps. As does global contexthttps://t.co/dDpgqd3vpfhttps://t.co/XOMiVDzCBO
2022-07-13 01:42:51 This is better than what might have been predicted with the relatively narrow observed immune response from BA.1., BA.2. Bodes well for some added protection vs BA.5 from a BA.1 booster
2022-07-13 01:39:59 @kallmemeg Yes, certainly, Meaghan. it's the known "boost (bird) in the arm (hand)" benefit now vs. some unknowns in the months ahead. No right answer, but the way BA.5 is erupting here would think to. take the up-front protective benefit for those at increased risk
2022-07-13 01:01:57 New study from Qatar on BA.4/5 reinfection—Protection of a previous infection against BA.4/BA.5 was lower than that against BA.1/BA.2 (>
2022-07-13 00:47:20 @ejwillingham and also seen with Delta, as they demonstrated. Thanks
2022-07-12 23:48:26 Another undesirable feature of the BA.5 variant: Enhanced antagonism of innate immunity not seen in prior Omicron variants (BA.1, BA.2) https://t.co/6AfXx0RuBOhttps://t.co/nQ9e9vs6fa
2022-07-12 22:15:23 Thinking about the overlap of Americans who are still Covid cautious and those paying close attention to the Jan 6th hearings...... and those ignoring both
2022-07-12 21:11:48 The US pandemic mortality gap vs Canadahttps://t.co/mkc4PuljI3 by @DFisman @PNASNews "How many lives could have been spared, had it emulated some of its global peers"Editorial accompanying paper by @Alison_Galvani and colleagues in connected post below https://t.co/OFIIN06A96
2022-07-12 17:40:00 @Ddrekonja Agree on that. Thanks
2022-07-12 16:55:36 Would add hybrid immunity to the boost later column (i.e. 3 shots and a prior infection). Note this refers to a 4th shot, with a person beyond 4-6 months from 1st booster
2022-07-12 16:52:14 I'm getting a lot of "To boost or not to boost" questions, so here's a Table with some recommendations now that boosters will soon be available to all adults. There are many uncertainties for waiting, and the original vaccine boost provides an extra layer of protection. https://t.co/FWq0m8p4g4
2022-07-12 16:16:10 BA.5 is now >
2022-07-12 15:40:20 @NightShiftMD Many thanks, Brian
2022-07-12 15:33:07 What happens if we don't take much more aggressive steps now towards nasal spray and variant-proof vaccines when an even worse #SARSCoV2 immune evasive variant shows up in the months ahead?
2022-07-12 15:21:12 Just published @ScienceMagazine are 2 more broad neutralizing antibodies with "unprecedented breadth" that add to a long list of well-suited candidates/basis for a universal pan-β-coronavirus vaccine https://t.co/VP75TyBMN7https://t.co/ZFT0pmYZXNhttps://t.co/VzCk5aELhY
2022-07-12 14:47:20 Today @CDCgov finally warned about BA.5Can you please fix the other issues on this punch list? https://t.co/AzO91kFuMQ
2022-07-12 14:35:39 @Laurie_Garrett @uche_blackstock @WhiteHouse Finally, the wake-up call ⏰
2022-07-12 14:17:31 @CarlosdelRio7 @latimes Thanks Carlos
2022-07-12 13:54:29 @CarlosdelRio7 @CDCgov The CDC is a major reason why this occurredA year after boosters were validated to save lives, the CDC still says "fully vaccinated"= 2 shotsAnd https://t.co/Amgvw8BEGw
2022-07-11 17:49:08 People keep writing "it's just a cold now." Wrong. https://t.co/HwRh6GlKd7
2022-07-11 17:49:07 You can't will it away.The rise of BA.5 globally https://t.co/xN9tUBUlla
2022-07-11 17:44:20 Good (new) summary of the @UK_biobank brain study. A larger cohort with paired imaging and matched controls from this exceptional resource is expected later this yearhttps://t.co/91yvemya8Lhttps://t.co/uLBchEop8E
2022-07-11 16:15:59 BA.5 has evolved substantially from its Omicron predecessor variants, now acquiring enhanced cell infectivity like Delta, beyond its formidable immune escape. What are the implications? https://t.co/ibgdJ7yYlIhttps://t.co/hcw2rZapOH
2022-07-11 14:53:45 @WHCOS @WHCOVIDResponse @ScottGottliebMD Yes it's critical. So why isn't it being shouted from the rooftops? "You should consider" is a different message than there is a body of evidence to show it's lifesaving.https://t.co/YzhFOuKPDmhttps://t.co/HGyjNwCm0vhttps://t.co/tcGQ0D9aM9
2022-07-11 14:13:30 Discussing the BA.5 variant status with @rosemaryCNN last evening https://t.co/XuLT6zp8XT
2022-07-11 14:03:55 RT @chrischirp: Quick Thread on Covid update in England:Firstly BA.5 and its child BA.5.1 are now the dominant variants and outcompeting…
2022-07-11 13:38:28 What country has a lower booster rate than Iran, Rwanda, Sri Lanka, Azerbaijan, Tajikistan and 61 others? https://t.co/gWCbSb6EfDThe United States
2022-07-11 13:24:33 RT @ddiamond: “BA.5 has taught us once again, the virus doesn’t just get milder and fade away,” @EricTopol writes. “While the virus revs up…
2022-07-11 02:44:04 There's a lot going on with the Omicron BA.5 variant. I wrote a new chapter to update its status https://t.co/ibgdJ7yYlI
2022-07-10 23:49:56 The double whammy of immune escape and increased infectivity
2022-07-10 18:14:53 "BA.5 could mediate not only extensive cytopathiceffects but was also significantly more infectious per diagnostic Ct value compared to the co-circulating BA.2 parental variant.""Appears to have evolved tropism towards pre-Omicron [cell] entry pathways"
2022-07-10 18:14:52 on BA.5 biology"Curiously, the change in BA.5 not only gives the virus greater antibody evasion potential but concurrently has changed its tropism [efficient use of TMPRSS2] along with an increased transmission potential in the community."https://t.co/U0r0ms6Mr7https://t.co/qgCKTCHKTb
2022-07-10 17:43:58 We desperately need #LongCovid biomarker(s)Many reports show persistent virus antigens, such as this recent small onehttps://t.co/nlrgzWIscM but a few counter https://t.co/pKFX1d7cTfWith millions suffering LC, it's long overdue this gets nailed down w/large, definitive studies https://t.co/kvJFDAMEjE
2022-07-10 15:53:35 The @uk_biobank brain study was quite concerning, so this new report is reassuring and welcome. We’ll need more high quality longitudinal studies (like these two) with extended follow-up to sort this out.
2022-07-10 15:20:39 The waste of 1.1 billion Covid vaccines that could have done a world of good to reduce deaths, hospitalizations, sickness and #LongCovid https://t.co/LXSEZObiu4 by @hannahkuchler @FT
2022-07-10 15:05:01 "America has decided the pandemic is over. The coronavirus has other ideas."https://t.co/5uRqAbZ14v by @JoelAchenbach
2022-07-09 23:16:00 @kallmemeg @profesterman @guardian Meaghan, Thanks for your post. I shared @profesterman's piece (an epidemiologist) for his perspective (not mine), which is not in my summary of BA.5 https://t.co/vwK1ZXsU7m.No intent to mislead. I will delete it and let him defend his calculation
2022-07-09 18:19:37 BA.5 got started in S. Africa and Portugal. Besides affecting much of Western Europe and the US now, it is leading to new surges in the Asian-Pacific region and South America. In most regions deaths have remained low to date@OurWorldInDatahttps://t.co/CbO1qpeuwA
2022-07-08 21:13:40 A systematic review of 43 studies on post-Covid reinfections from 17 countries. Pre-Omicron protection was very high and durable (Left panel)Post-Omicron: substantially lower and declined more rapidly (Right panel)https://t.co/YOFrTTAKzc by @IHME_UW https://t.co/blooSrvaFC
2022-07-08 20:39:23 Link to the @CDCgov site which provides "community level" virus by county, a deceptive and hazardous view of our BA.5 situation now. Hidden behind that on the site is the "community transmission level," as previously shown (and below)https://t.co/cp8qDLJbEnhttps://t.co/ujP2kooI9J
2022-07-08 18:07:29 New and outstanding @SciImmunology review on #LongCovid and other respiratory viral infection chronic sequelae with particular attention to lung impact https://t.co/iivxZXQIc5by @hnarasim23 @Jie_Immunology @goplenNP @Yue_Wu_IMM @UVA_MIC @MayoClinic https://t.co/ZzuQ95YDlL
2022-07-08 17:17:10 Reference for 5 days as median for length of infectiousness (best proof is not a rapid test but how long the virus can be cultured)https://t.co/OSIzRKxt33
2022-07-08 16:46:27 This is our @CDCgov X No warning on BA.5X Still says 2 vaccine doses ="fully vaccinated"X Says 5 days is all that's needed for isolation when 5 days is the median length of infectiousnessX 1 in 4 age 50+ w/ 2nd booster (<
2022-07-08 15:56:18 @cellhostmicrobe More on BA.4/5 immune escapehttps://t.co/7yDUJ5vTxqWith simplified street-sign view of its antigenic distance from prior (sub) variants that account for this property https://t.co/pmEH6HvurU
2022-07-08 13:57:03 Why is it the "worst variant" yet?Not because it causes worse disease. There is no evidence for that.Because it is the most transmissible and most immune-evasive of any version of the virus since the pandemic began.https://t.co/vwK1ZXsU7m
2022-07-08 04:03:06 @mocoband @LaurenLeatherby Yes, thanks. Introduced in Mayhttps://t.co/P7KQmSc8qK
2022-07-08 02:49:51 @mattyglesias @dgmacarthur Agree with @patrickc for what is holding us back. It's not the science, as we wrote about in early 2021https://t.co/eKHGg7EPtM @Nature
2022-07-08 02:45:06 RT @michaelmina_lab: Goes without saying at this point…Test before exiting isolation to know you are no longer infectious(Do not listen…
2022-07-06 21:01:00 Understatement:"The rapid emergence of new variants makesvariant-specific vaccine development dificult" https://t.co/kLAuVbkDps@NEJM todaya.k.a variant chasingPan-β-coronavirus and nasal vaccines would avoid V-chasing and can help get is to variant-proof status, ahead of https://t.co/fIsYc3bdlK
2022-07-06 17:33:20 @LeanneGSinger @AshishKJha46 Agree! Instead of throwing away tens of millions of vaccines about to expire, they should be distributing 4th shots to all who want them
2022-07-06 17:22:39 Genome editing for potential definitive treatment or curies for many genetic conditions is moving forward at high velocity. A new @CellCellPress review is a masterful state-of-the-science for deliveryhttps://t.co/SJtJ512NE1 @davidrliu @samagyabanskota @liugroup @broadinstitute https://t.co/jYdghFsF3s
2022-07-06 14:14:15 Such profound waste of tens of millions of vaccines that could have saved lives, prevented hospitalizations, sickness and #LongCovid @Loftus https://t.co/qF8324imGG
2022-07-06 13:18:35 More on this from brain neuroinflammation in 24 patients and matched controlshttps://t.co/t8JQqSx5B8 5 severe Covid patients had #SARSCoV2 immunoreactive neurons in brainstem nuclei https://t.co/GzfT2gjVMF
2022-07-05 23:42:26 The microvascular injury and inflammation of the brain, with immune complex formation, that can occur from Covid, from in-depth assessment of 9 patient autopsies and controls. https://t.co/AWbo70nrBK by @NINDSnews https://t.co/oiBC8lXygI
2022-07-05 23:03:26 US CDC genomic surveillance updateBA.5 growth marches on, now 54%BA.4/5 combined >
2022-07-05 15:05:04 For both 2020 and 2021, Covid was the 3rd leading cause for death in the United States, by @theNCI @JAMAInternalMed In 2021, it was the #1 cause of death in Americans age 45-54 https://t.co/hFcvKAomERhttps://t.co/pH8sBTbLz5
2022-07-04 18:17:21 RT @shannonrwatts: Having unfettered access to 400 million guns isn’t freedom. Being able to take your kid to a Fourth of July parade witho…
2022-07-04 16:34:16 —I'd like an inhalable Covid vaccine with exosomes decorated by #SARSCoV2 receptor being domain—Sure, here it ishttps://t.co/RSBJaVNzm0 @NatBMESeriously, we need nasal spray vaccines
2022-07-04 15:39:32 If you're into #AI for healthcare, an essential new review article @natBME today https://t.co/3F0row83l6@Joseph_C_Wu @james_y_zou Angela Zhang @StanfordMed @StanfordCVI https://t.co/ljeO8Mji7J
2022-07-04 15:08:29 The basis for concern about the Omicron BA.2.75 variant. 8 mutations beyond BA.5, many in the N-terminal domain, which could make immune escape worse than what we’re seeing now. Competing w/ BA.5 in India. Excellent thread by @EllingUlrich https://t.co/Ko5AYxEonv
2022-07-04 14:50:22 @mebottazzi Congratulations for this richly deserved recognition!
2022-07-04 14:38:21 Celebrating Great Immigrants, Great Americans, the essential contributions of immigrants to American LifeSuch as @ardemp &
2022-07-04 03:49:38 RT @Bob_Wachter: Covid (@UCSF) Chronicles, Day 838The die is now cast: BA.5 is destined to be our dominant virus. In today’s I discuss t…
2022-07-04 01:22:02 RT @deschiam: If you do nothing else please read this. I get the fatigue but this is not doom and gloom. There is a path out but we have to…
2022-07-03 17:20:11 Relevance to Omicron infections"Omicron infection had little or no beneficial effect of boosting any part of the immune system — antibodies, B-cells or T-cells — among people who had been imprinted with earlier #SARSCoV2 variants"https://t.co/PE4QjMv69U@ScienceMagazine
2022-07-03 16:43:08 Impact on optimizing boosters, timing, and next-generation of Covid vaccines"Patterns of anti-spike immunity in different people and populations have become heterogeneous, complex and unpredictable"by @clivecookson @JamieSmythF @ian_bott_artist https://t.co/z4dT40Fwjy
2022-07-03 16:43:07 What is immune imprinting and why it is important?A superb explainer“Our first encounter with the spike antigen, either through infection or vaccination, shapes our subsequent pattern of immunity through immune imprinting" —@BoytonRosemaryhttps://t.co/OYMd5RRe1jhttps://t.co/8hfXjGno29
2022-07-02 23:28:27 Small study of health care workers suggests possibility that there may be increased protection from #LongCovid with increased doses of vaccine https://t.co/1tBWtHdsJM @JAMANetworkOpen https://t.co/n0OhnsxTRL
2022-07-02 20:50:29 @RajlabN @Mike_Honey_ Thanks. But I’m referring to sign of growth of BA.2.75 here. Not 2 isolates. We’ll obviously be seeing more if it in the days ahead
2022-07-02 19:13:09 Connecting the dots for these 2 sequential @KPSCalResearch reportsVaccine effectiveness vs hospitalization, 3 mRNA shots, <
2022-07-02 18:13:38 Omicron subvaraints in the US—BA.5 is likely >
2022-07-02 17:09:46 @DianaGHealth @MiamiDadeCounty Yes, concerning, and across the US test positivity only exceeded during initial Omicron wave
2022-07-02 16:24:03 The same @KPSCalResearch group previously published their data with 2 or 3 mRNA shots over time for Delta and Omicron. Vaccine effectiveness vs hospitalization vs Delta was 89% (95%CI 83-93) for <
2022-07-02 15:57:05 The need for better vaccines vs Omicron subvariantsReduction in 3-shot mRNA vaccine protection vs Emergency Department admission from BA.1 to BA.2 (5% at ≥ 3 mos) https://t.co/mxSyJaHRmN3-shot vaccine effectiveness vs hospitalization 80% BA.1, 74% BA.2 at <
2022-07-01 20:21:16 RT @EricTopol: Has the @CDCgov warned you about BA.5, now accounting for ~37% of Covid cases, a liability for reinfections, less protection…
2022-07-01 17:01:01 RT @john_actuary: Another 39% increase in today's admissions figure, to 1,572, bringing the weekly average to 1,290, itself up 34% on the w…
2022-07-01 16:47:13 "It is both perplexing and not a little devastating that this mysterious, lingering disease finds a way to continue wreaking havoc in the face of a largely vaccinated population and a supposedly milder variant."—@Daltmann10 https://t.co/NbWldSRi0Q @guardian via @JeremyFarrar
2022-07-01 15:39:50 The importance of investigating unexpected findings:the role of a silent KRAS gene variant in cancerhttps://t.co/J1MjkFTbZa by @molina_arcas @JulianDownward @NEJM https://t.co/51sToFMIxH
2022-07-01 05:06:51 RT @JPWeiland: Positivity rates have only been higher two times since the beginning of the pandemic. The first weeks of the pandemic, and…
2022-07-01 00:45:58 RT @AI4Pathology: Our @TheLancet perspective w/ @EricTopol highlights key findings from our recent @NatureMedicine article about AI-driven…
2022-06-30 22:39:03 The 3 figures from the study to convey these 2 points https://t.co/ygFwdSJWqI
2022-06-30 22:34:55 Largest study of BMI and Covid vaccination—Underweight/low BMI less likely to get vaccinated + severe disease risk after 2nd dose higher in than in people w/normal to high BMI (need 3rd shot)—Obesity did not impact vaccine effectivenesshttps://t.co/nrEtKhwowK @TheLancetEndo https://t.co/X8I4xEBSbI
2022-06-30 20:25:54 Impact of "The hiatus of the handshake"https://t.co/ML50IIZvDV @ScienceMagazine @kbratnelson @B_Lopman @EmoryRollins @EmoryEPI A thoughtful essay on what we've learned from the pandemic, the rippling effects on other infectious diseases spread, &
2022-06-30 18:47:20 A new, tour de force review of the gut microbiome and its implications for health and disease https://t.co/jOIuUaF60l @ScienceMagazine @abaumler @TsolisRenee @Jeeyon84 @ucdavis https://t.co/0R94eGpbt4
2022-06-30 16:37:29 @RobertoBurioni @ScienceMagazine @NewsfromScience @RobertFService Hope you are right, RobertoSince the potential exists, it would be ideal to have other drugs and combinations ready
2022-06-30 16:07:51 Here's the US Covid hospital admissions, log-scale, with BA.5 on the rise https://t.co/icf7bUryc4
2022-06-28 16:57:53 RT @Bob_Wachter: Great BA.5 primer by @EricTopol. Key points:1) Will be dominant variant soon2) infectious &
2022-06-28 15:13:46 Maternal mortality in the United States, highest of all 38 @OECD countries, increased during the pandemic and now, with banning of abortion in many states, is positioned to go even higher, w/ disproportionate impact by race and ethnicityhttps://t.co/HwPyEHs6ty @JAMANetworkOpen https://t.co/NBlQEm0M5m
2022-06-28 14:55:19 The comprehensive list of the actions taken during the pandemic to get ahead of the virus https://t.co/QxKHUKCz9v
2022-06-28 14:46:01 Note there is no BA.1 while the @US_FDA Advisory Committee debates today the merit of an EUA for a BA.1 booster that has a 3-fold drop in neutralizing antibodies vs BA.4/5https://t.co/6X3AwmEfolhttps://t.co/18vu12n7e4
2022-06-28 14:11:11 10 years ago today a @ScienceMagazine online paper with an obscure title turned out to be the beginning of the most important life science breakthrough in many decades: #CRISPR genome editinghttps://t.co/y23NPGumVV @carlzimmer https://t.co/gO4JoMgUkA
2022-06-28 02:20:03 This variant is center stage for the @US_FDA Advisory Committee hearing tomorrow about updating vaccines and the question of (EUA) approval of an Omicron (BA.1) booster (a variant that is no longer circulating)https://t.co/eHgCgUvnO0 by @SharonLNYT
2022-06-28 02:11:33 When it comes to #SARSCoV2 and Covid, it's important to keep your eyes on the ball. The ball is BA.5 and here is what we know about ithttps://t.co/vwK1ZXsU7mhttps://t.co/qaH1eTdqPO
2022-06-27 21:18:58 RT @chrishendel: "It’s frankly sickening to watch this virus continue to outrun us, knowing we are so damn capable of getting ahead of it"…
2022-06-27 20:51:08 I wrote about about the Omicron BA.5 variant: (1) what we know about its biology
2022-06-27 16:08:16 A new outstanding review on the antibody response to #SARSCoV2 https://t.co/7NbLF1HBQy @NatImmunol and the path to variant-proof Covid vaccines https://t.co/hnZnCnyzYr
2022-06-27 15:15:55 The promise of digital health. Our new @theNAMedicine perspective piecehttps://t.co/SfNm1YwuAu "A digital health ecosystem that provides high-quality, personalized, equitable care to all who need it is achievable and worthy of our best individual and collective efforts." https://t.co/8jE2J5OTjr
2022-06-27 14:05:42 Canada has done remarkably well throughout the pandemic compared with peer countries (G10) for major outcomes and vaccinations https://t.co/nJflYNqLHY @CMAJ https://t.co/3lWZOii6iQ
2022-06-26 17:35:28 A timely an important update, thread from @jburnmurdoch on this https://t.co/EA7K4i81wn
2022-06-26 15:09:00 BA.5 has the most transmissibility and immune escape of any version of the virus since the pandemic began. Although its spike(S) sequence is nearly the same as BA.4, there are several mutations in other parts of the virus that may account for itsfitness https://t.co/nKnmp5OBZKhttps://t.co/dUsPxu2LILhttps://t.co/9feAvwKAMY
2022-06-26 14:45:10 @thehowie That's incredibly kind of you, Howie. Deep thanks!
2022-06-26 14:41:53 This is the simple graph that should have been in the paper, #dataviz from @TheEconomist for saving ~20 million lives in the first year of Covid vaccinationshttps://t.co/bFNPnYyPCd @ECONdailycharts https://t.co/7WDD0YoJ4O
2022-06-25 19:48:49 RT @IAmPoliticsGirl: A court that abandons its own precedent, undermines its own authority. https://t.co/uZOtzRYQtX
2022-06-24 16:49:54 A real CDC would be aggressively disseminating these data and doing everything possible to prevent unnecessary deaths from Covid https://t.co/Qj3lAZ8K4y
2022-06-24 14:26:27 RT @luckytran: Today, the CDC Director flippantly dismissed the importance of counting rapid tests."You don't need to count the rain drop…
2022-06-24 14:17:44 @clivecookson @alexisak @OurWorldInData @FT @jburnmurdoch @JamieSmythF Thanks Clive. Yes, well shown here https://t.co/zEKob7UFZr
2022-06-24 13:57:20 @alexisak @OurWorldInData @FT @jburnmurdoch @JamieSmythF Yes, I cited ithttps://t.co/pu7tSg4YwBBut a lot more is happening since then (and beyond Europe) attributable to BA.4/5
2022-06-24 01:46:18 RT @EricTopol: New @CDCgov data on 2nd booster protection from death for people age 50+, compared with unvaccinated, through Omicron BA.1,…
2022-06-24 00:05:47 "Trust in science has actually become a matter of life and death.”—@NaomiOreskeshttps://t.co/qCmowtRfHI @TheLancet Cover and profile of Professor Oreskes https://t.co/DMeuvBJjgF
2022-06-23 22:30:00 @TheLancetInfDis In the 1st year of Covid vaccinations, ~20 million deaths were prevented worldwide (data from 185 countries)Another ~600,000 lives would have been saved if the @WHO 40% target been achievedhttps://t.co/BWig83xlnN @azraghani @imperialcollege @MRC_Outbreak https://t.co/lF8biBJIlK
2022-06-23 21:57:17 A new study of the "atomic-level dynamics by multiple microseconds simulations" for how the #SARSCoV2 spike gets modified to more efficiently enter host cellshttps://t.co/Pybvy05L2q@PNASNewshttps://t.co/Z1Q3cPpP86
2022-06-23 19:10:46 Just out @ScienceMagazine "Our findings highlight the urgent need to find next-generation COVID-19 vaccines and broad-spectrum therapeutics, as well as to tighten non-pharmaceutical measures to reduce acute and chronic disease burden (#LongCovid)..."https://t.co/LGBn3krkEf
2022-06-23 19:06:08 The antigen distance map of #SARSCoV2 variants through BA.1 and BA.2 "BA.1 and BA.2 both escape vaccine-induced antibody responses as a result of different antigenic characteristics" Needs a BA.4/5 update, off the chart https://t.co/GGYW6AaMdF @SciImmunology https://t.co/GoE6YC14wz
2022-06-23 18:32:43 A bacteria, as a microbe, is expected to only be visible via a powerful compound microscope. Until this one that was discovered to be macroscopic, reported today @ScienceMagazine https://t.co/KjRYmaU1hA @PetraLevin Easy to remember its name if you like very large margaritas https://t.co/VzeWmuyMM4
2022-06-23 17:56:40 @AstroKatie No good reason. See US hospitalization data by age groups https://t.co/M2Bu9rj1Ve
2022-06-23 17:35:08 The Israeli researchers nailed this down back in February and have published extensively on the protection of the 4th shot for reducing death and severe diseasehttps://t.co/W4xkPskVdP
2022-06-23 16:23:17 Only 1 in 4 Americans age 50+ have had a 2nd booster. https://t.co/k1hTZD8CciPlease go for it. It could be lifesaving.
2022-06-23 16:19:26 New @CDCgov data on 2nd booster protection from death for people age 50+, compared with unvaccinated, through Omicron BA.1, BA.22 boosters: 99% reduction 1 booster: 86% reductionVaxx, no boosters: 81% reductionhttps://t.co/HGyjNwCm0vhttps://t.co/yaEtuClQA5
2022-06-23 16:07:49 RT @kallmemeg: A little sent me these. The BA.4/5 wave is here… https://t.co/ojQ7b2TNgQ
2022-06-23 02:42:26 A few added mutations in the spike sequence (BA.4/5) are leading to even more immune evasiveness and a new Covid wave in many places around the world https://t.co/xMlXAyb6VY
2022-06-21 16:22:26 Sorry, meant to link this risk of reinfection paperhttps://t.co/AiV7P6hQLO
2022-06-21 16:18:49 Before Omicron the chance of reinfection was ~1%. That has markedly increased w/ Omicron, especially for BA.4/5 with reduced protection from BA.1 infections. Reinfections carry substantial risk, as shown in this new analysis, so please keep your guard uphttps://t.co/Rx6p2lLw66
2022-06-21 15:28:32 The BA.4/5 impact is just starting to take hold, with no region of the US at a dominant level yet. It is also on a path to dominance in multiple countries in Europe, and Australia, with some attributable increases in hospitalizations https://t.co/pu7tSg4YwBhttps://t.co/CO1gfjwKSQ
2022-06-21 15:23:01 BA.4/5, the Omicron subvariants with the most immune escape (and highest transmissibility) since the pandemic began, now account for 35% of new cases in the United Stateshttps://t.co/jjl2AnwOWXhttps://t.co/teIGeGTUVC
2022-06-21 15:01:58 Americans spent ~$50 billion on vitamins and supplements in 2021. A new systematic review of 84 studies shows they are a "waste of money," lacking value in non-pregnant adults, and specifically risk of beta-carotene and lack of Vit E effect @JAMA_current https://t.co/mTPSw1u7kp
2022-06-21 14:36:06 Having so many new and repeat infections during a prolonged Omicron subvariant wave (BA.2.12.1, BA.4/5) with their toll on sickness and #LongCovid should not be comforting or give anyone the impression this is behind ushttps://t.co/FrGtjbmmf2https://t.co/8WzkZSI2FD
2022-06-21 01:27:07 RT @mcuban: Hey @JoeBiden , @LeaderMcConnell, @SpeakerPelosi , @GOPLeader, @SenSanders @RonDeSantisFL @AOC have your people call my peop…
2022-06-21 01:19:30 Covid reinfections are not benign: ~39,000 people w/reinfections vs ~5.4 million controls indicates extensive and persistent risk with a "dose-response" (more risk with repeat reinfections) https://t.co/v8nZXBEuNdby @zalaly @BCBowe @Biostayan @WUSTLmed @VAResearch https://t.co/U4pPQZLEaB
2022-06-21 00:21:08 Text and more data from the reportNote the vaccines that participants had received were Sinopharm (BBIBP-CorV) and Anhui Zhifei Longcom (ZF2001) https://t.co/jKAs8p4hIb
2022-06-20 23:58:35 Post-vaccination breakthrough infections with Omicron subvariants (BA.1, BA.2) lead to a narrow, specific neutralizing antibody response setting up vulnerability to BA.4/5 https://t.co/Kf7hDxZaf1 @TheLancetInfDis https://t.co/gkwj8XpVIX
2022-06-20 21:27:35 The new paper was based on <
2022-06-20 21:17:53 Table from the paperAnd https://t.co/sH9CNbZPAlExamples for 2 of the most frequent drugs I prescribe vs retailLisinopril for BP ($3.60 vs $24)Atorvastatin ($3.60 vs $55.20) https://t.co/V5EK6vCb9h
2022-06-20 21:10:04 The many $ billions the US could save each year by @mcuban's @costplusdrugs (MCCPDC) is remarkablehttps://t.co/3vVXM2TbnL@AnnalsofIM @BrighamWomens by @DrHussainL @PORTAL_Research @akesselheim @bnrome https://t.co/eyGwDewo1x
2022-06-20 19:34:35 Speech and spread of #SARSCoV2 "Our results suggest that the quantity of speech aerosol, in particular in the ≥ 4-μm range, may have been strongly underestimated in many prior reports"https://t.co/z4z0xj4h3g <
2022-06-20 19:07:19 "What SARS-CoV-2 does to our brains"https://t.co/8c7ORLBvgr @ImmunityCP potential of immune systems response both acutely and w/ #LongCovid @HelenaRadbruch @f_heppner @ChariteBerlin https://t.co/ktFYe6QHlS
2022-06-20 17:58:35 Deep learning #AI to rapidly identify new driver mutations in 37 types of #cancerhttps://t.co/C6V85OgfSjby @MIT_CSAIL @lab_berger @m_a_sherman @olivercpriebe @AdamYaari @NatureBiotech https://t.co/SQCdzRFZBS
2022-06-20 17:43:14 “I don’t think there can be any doubt in anyone’smind that these are a source of new variants”—@GuptaR_lab https://t.co/YXiaN6j12K @Nature by @ewencallaway https://t.co/xBoipvrpT8
2022-06-20 16:12:42 The role of digital surveillance and real-time individualized risk assessment throughout the pandemic has not been adequately emphasized
2022-06-20 16:00:54 The evolution of #SARSCoV2 in immunocompromised people with chronic infections is driven by immune evasion, especially seen w/ viral rebound, and requires extensive genomic monitoring for detection of new VOCs @NatureMedicine https://t.co/GFK4nW10Ljhttps://t.co/cNF1ivKViU
2022-06-20 15:12:55 Just published @NatureBiotechOur review of smartphone apps for Covid-19: outbreak epidemiology, individual screening, contact tracing and their futureby @JayPandit @jmradin @GiorgioQuer @ScrippsRTI @scrippsresearch https://t.co/NswHMmNmRlhttps://t.co/9pNO2VCnde
2022-06-18 21:25:39 RT @Medscape: .@EricTopol speaks with @DeepMind CEO @demishassabis about harnessing the potential of AI in health and medicine. https://t.c…
2022-06-18 16:51:09 How can you go from sequence of a novel virus to 2 vaccines with 95% efficacy and safety (>
2022-06-18 16:43:11 ‘Why aren’t we having a vaccine...that gives you a 5- or 10-year duration of protection like most vaccines?"— @PeterHotez
2022-06-18 16:43:10 ‘‘In terms of what really keeps me up at night, it’s the knowledge that we can’t keep boosting."—Dr. Peter Marks @US_FDAhttps://t.co/gLmtGp2WTf by @StephArmour1 https://t.co/j22vTDxmDo
2022-06-18 15:11:18 Concerns echoed herehttps://t.co/4VT2MQVphu"Uğur Şahin warned that a sub-variant of Omicron that fully escapes vaccines’ protection might emerge as countries prepare to launch autumn booster campaigns"@hannahkuchler @JamieSmythF https://t.co/RwBbG1nDih
2022-06-17 16:56:44 The Omicron BA.4/5 subvariants are leading to a new wave in Europe and the United States, with an impact of some increase in hospitalizationshttps://t.co/y0LvkzoCRb @SarahNev @JamieSmythF @jburnmurdoch @TWenseleers https://t.co/pBuS7Xc5Li
2022-06-17 16:41:58 A noteworthy failure of individualized medicine (or amyloid hypothesis) for prevention of Alzheimer's disease: a randomized, placebo-controlled trial of a monoclonal antibody for people w/ presenilin 1 mutation (amyloid precursor) failed to show benefithttps://t.co/e5cwN4UIsYhttps://t.co/KAG3AjfpQZ
2022-06-17 15:18:31 Just published @Nature The extent of immune evasiveness of Omicron subvariants BA.2.12.1 and BA.4/5 raises concern about effectiveness of the Omicron (BA.1) specific vaccine booster impacthttps://t.co/foDTHDo49phttps://t.co/2WmXQHmRwr
2022-06-17 15:08:07 Oh, really?
2022-06-17 03:11:51 A review of what we know about 3 theories that may represent underpinnings of #LongCovid @ScienceMagazine: (1) microclots, (2) persistent virus, and (3) immune system gone haywirehttps://t.co/KuY8N9dVp6
2022-06-17 02:40:13 Substantial (~50-75%) reduction of #LongCovid with Omicron compared with Delta variant, magnitude influenced by age and time since vaccination @TheLancet https://t.co/shAzJn8WSjhttps://t.co/bXoct0sXd1
2022-06-16 16:55:35 There's only 1 person who fits this profile and he's one of the leading forces in the world for advancing #AI, solving intelligence, and fortunately for us much of that work is in life science, such as #AlphaFold https://t.co/vqUEkGqvzyA conversation with @demishassabis https://t.co/XmvkX8fLA2
2022-06-16 16:33:26 The genetic distance (GD) of #SARSCoV2 variant's receptor binding domain predicts vaccine effectiveness vs symptomatic infections (from ~2 million sequences, 49 studies, >
2022-06-16 02:37:51 RT @demishassabis: Thanks for having me on the podcast @EricTopol, was one of the most fun and wide-ranging conversations I've had, discuss…
2022-06-15 21:28:19 2. Continued "That previous #SARSCoV2 infection history can imprint such a profound, negative impact on subsequent protective immunity is an unexpected consequence of COVID-19" —@BoytonRosemary @Daltmann10 and colleagues @ScienceMagazine https://t.co/dFtjfp9cGY
2022-06-15 21:28:18 A 3-fer on Omicron infections1. Vaccine protection vs BA.1 and BA.2 variants similar, national Qatar study https://t.co/VVcQuMSNqR @NEJM2. Evidence of imprinting ("antigenic sin") by ancestral or Alpha infections w/ reduced immune response to Omicronhttps://t.co/PE4QjMv69Uhttps://t.co/WVT2M6xKBt
2022-06-15 17:34:25 I’ve done a lot of interviews over the years, but I can’t remember one as enthralling as this one with @demishassabis on #AI, #alphafold, foundation models and the future of biomedicine @DeepMind w/transcript https://t.co/vqUEkGqvzy
2022-06-14 15:56:02 @FSBuchholzer @KasperKepp @apsmunro Actually, your accusation &
2022-06-13 22:52:54 RT @EricTopol: "We estimated that a single-payer universal healthcare system would have saved 212,000 lives in 2020 alone. We also calculat…
2022-06-13 20:33:08 “But the threat – mostly of long-term problems – seems too big to ignore.”Thanks Bob for this very important thread https://t.co/BkQzKexv5m
2022-06-13 20:14:03 Link to paper https://t.co/eNKJhkt1GX w/ @MeaganCFitz @AlyssaParpia @abhiganit and collaborators
2022-06-13 20:14:02 "We estimated that a single-payer universal healthcare system would have saved 212,000 lives in 2020 alone. We also calculated that US$105.6 billion of medical expenses associated with COVID-19 hospitalization could have been averted by a Medicare for All system."@Alison_Galvani https://t.co/cbE58eBprh
2022-06-13 17:37:35 "We explored the neurobiological effects of [mild] respiratory SARS-CoV-2 infection and found white-matter-selective microglial reactivity in mice and humans" Parallels to chemo-brainhttps://t.co/R8LoXsCDcO @michelle_monje @VirusesImmunity @ThisIsAnthonyFC @CellCellPress https://t.co/Fq1QlopJiF
2022-06-13 16:26:26 @euanashley Thanks Euan
2022-06-13 16:22:43 The Peizo1 ion channel protein was found to trigger cardiac hypertrophy, with important potential implications for an unmet clinical needhttps://t.co/0aRm4vGekL@NatureCVR @VictorChangIns @BorisMartinac @justsaysinmice https://t.co/W1IswsfQLI
2022-06-13 15:32:53 @NatureBiotechA rapid (<
2022-06-13 14:40:24 "These kinds of vaccines could buy us long-lasting protection against infections and disease. When combined together, our armamentarium for fighting Covid is growing" On the potential of nasal and pan-β-coronavirus vaccineshttps://t.co/UhoGKQdBFO by @deeptabhattacha @nytopinion
2022-06-13 14:33:15 A cluster of unprecedented reports of individualized medicine for cancer—I've tried to summarize and contextualize here https://t.co/uM9vNK1tF3
2022-06-12 23:01:00 Our brains get hotter than anticipated: 1st 4-D map of healthy human brain temperature indicates deeper brain regions often exceed 40°C, especially for women during the daytime https://t.co/o0Xdm5f7d9 by @Neurocool and colleagues @MRC_LMB @Brain1878 https://t.co/Sx0d8uvDzo
2022-06-12 22:25:39 Worthwhile insights on this from @karpathy and @cajundiscordian https://t.co/kRzal3bFeJ
2022-06-12 17:45:37 To contextualize this post, in particular, that has evoked considerable interesthttps://t.co/CPwDqlV2KD
2022-06-12 17:45:36 A Google engineer @cajundiscordian claimed it was and was put on paid administrative leave for violating its confidentiality policy https://t.co/RM1wwUELfN by @nitashatiku with balanced perspective https://t.co/UJHZmbROJL
2022-06-12 16:06:24 @BlocknixBibi You are VERY wrong. The Covid pandemic is not just about deaths. There's this thing called #LongCovid affecting millions, you fail to acknowledge. There are millions of people sick right now, and hundreds of thousands in hospitals around the world for Covid, many in the ICU
2022-06-12 15:39:21 "73 percent of people who die of cancer had cancers that are not detected by standard tests" https://t.co/vwK8yOY7hYCould a new $949 blood test change this?Not yet. I wrote about it here>
2022-06-12 15:12:36 The mysterious acute hepatitis in children is being called Long Covid Liver https://t.co/nuW0jyhQk5
2022-06-11 22:43:39 RT @VirusesImmunity: A brilliant &
2022-06-11 22:21:48 RT @DKThomp: “I believe this is the first time this has happened in the history of cancer”https://t.co/gaEMq13lH7Here is the shot of ne…
2022-06-11 22:20:25 RT @PeterHotez: It’s really interesting @EricTopol how the same subvariants are now producing such widely divergent public health effects i…
2022-06-11 18:55:56 Not every day you see 3-year follow-up of one-shot genome editing to keep 31/31 people with severe sickle-cell disease without any crises and 42/44 with beta-thalassemia without transfusionshttps://t.co/QpFJGa1Kxr #EHA2022 @CRISPRTX
2022-06-11 18:27:55 Last week BA.4/5 accounted for 13% of new cases in the US (95%CI 9,18%)Note the biologic features of these 2 variants in the posts below https://t.co/90n2CrRkzx
2022-06-11 18:15:27 Not a good idea to capitulate when the #SARSCoV2 variants with the most immune escape since the pandemic began are into exponential growth, especially when there's so much that could be done beyond the usual measureshttps://t.co/N5zk6WaGIt
2022-06-11 18:15:26 US cases are still rising, 7% increase week-to-week, >
2022-06-11 18:00:05 BA.4/5 is on the rise to become dominant in the US and UK. It hit South Africa and Portugal first. Note the difference in impact for those 2 countries in deaths https://t.co/9Y4io9tZwo
2022-06-11 15:36:57 RT @stevenbjohnson: “The narrative has been incubating for many years, but in recent days we are witnessing some extraordinary progress in…
2022-06-11 14:31:37 If you're looking for some very upbeat biomedical stuff, here it ishttps://t.co/uM9vNKj53D…Including the first time immunotherapy alone eliminated the need for chemotherapy, radiation and surgery
2022-06-10 23:20:56 @EagleMD3 Much appreciated
2022-06-10 23:04:56 @cocodoxy Thank you!
2022-06-10 22:49:00 I wrote about a cluster of new individualized medicine reports for cancer that are noteworthyhttps://t.co/uM9vNK1tF3
2022-06-10 16:49:47 Science communication during public health criseshttps://t.co/GxdFO841cI @Clin_Chem_AACC @_AACC w/ @hholdenthorp @apoorva_nyc @jsross119 @dicktofel @ClinChemJoe https://t.co/AQRp5J9qi5
2022-06-10 15:46:49 The Omicron subvariant wave (particularly BA.4/5) is starting to emerge in the UK and the implications are nicely summarized in this https://t.co/Zymh4BqGOK
2022-06-09 23:14:12 In case you are not familiar with the nuclear pore complex, it is in every cell of your body (that has a nucleus), comprised of >
2022-06-09 22:21:43 At @TheEconomist, a great overview on foundation models, an exciting, rapidly evolving frontier in #AI. Best line:"True, foundation models are capable of behaving like an idiot, but then humans are, too."https://t.co/HK0FYbahd4https://t.co/eqdvWTbdD9https://t.co/xvMrwX7uuh
2022-06-09 18:33:39 Today is a BFD triumph in life science—solving the 3D structure at near atomic level resolution, one of the world's hardest, giant jigsaw puzzles—the nuclear pore complex—the largest molecular machine in human cells, with structure-based AI prediction @ScienceMagazine https://t.co/k2B91KOr8B
2022-06-09 16:01:53 We've chronically undervalued the importance of diet for promoting &
2022-06-09 15:34:43 With all we've learned in recent years about the gut #microbiome, what is healthy eating now?https://t.co/ashCdpiVzp A tour de force review @cellhostmicrobe https://t.co/beTCzbUj2P
2022-06-09 15:24:43 The BA.4/5 variants, the next chapter of the pandemic in the US and Europe, is a story of immune escape, nicely characterized in this new @CellCellPress paperhttps://t.co/1aCfzw6ivOhttps://t.co/mhA87niphU
2022-06-09 01:37:30 New @NatureMedicineGood to see @KPSCalResearch, large health systemOmicron BA.1, BA.1.1, BA.2 infections had far less unfavorable outcomes than Delta, *adjusted*, ~40% less hospitalization, ~80% less death (vaxx or no vaxx)https://t.co/dYwYnzTu0rhttps://t.co/T0snElzTxO
2022-06-08 23:31:42 The march of the Omicron subvariants will prolong the current wave, which is the highest case burden except during Omicron BA.1 in the US pandemic, adjusted for lack of central/PCR testing https://t.co/oeV2d8JkIL
2022-06-08 23:18:38 A simplified mutation map of the changes in the spike protein for the US Omicron subvariant wave https://t.co/JlIP7KuUFf
2022-06-08 22:47:35 Omicron subvariants response to monoclonal antibodies: more immune escapeTable (lower number, more sensitivity) vs BA.2BA.4/5: ~20-fold more resistant to Evusheld(on path to US dominant)BA.2.12.1: 4-fold more resistant (now dominant in US)https://t.co/cULie0sU8Hhttps://t.co/4EmKghcz7l
2022-06-08 21:04:40 "Our results underscore the potential importance of selective pressures such as the use of monoclonal antibodies — in combination with the lack of an effective endogenous immune response--in promoting escape mutations"https://t.co/Gtzmv6y3AN in 5 immunocompromised patients @NEJM https://t.co/veGpi3Vhhr
2022-06-08 15:33:24 More evidence of #SARSCoV2 viral reservoir in some patients with #LongCovid "the presence of residual virus within the appendix and breast tissue of 2 patients who exhibited LC symptoms"https://t.co/bc36mOGyxdhttps://t.co/V4nC8NzqEM
2022-06-08 04:00:31 @GetOffMyLawnPod That there's potential that Paxlovid might not work very well in the future
2022-06-08 03:45:43 High level Paxlovid resistance (up to 80-fold) can be created in lab w/ highfitness2 reports replicate (mutations L50F, E166V/A, +/- L167F)https://t.co/EoLVXLRcKhhttps://t.co/FTyE4RP8yRSupports need for genomic surveillance + development of more potent oral anti-viral pills https://t.co/s3Azsw97Tb
2022-06-07 23:03:11 Reduction of severe Covid increased when Evusheld given early, and present/similar magnitude across nearly all subgroups https://t.co/MbtUtdXhTq
2022-06-07 22:56:27 @LancetRespirMed A randomized trial of Evusheld vs placebo reduced severe Covid, from 9% to 4%, among 910 participants (RRR 50.5%). Previously Evusheld had proven efficacy for prevention in immunocompromised
2022-06-07 21:07:01 @JeffBlackham @FryRsquared Agree!Important data point @FryRsquared reviewed for chemotherapy after breast cancer surgery in 100 women. How many does it actually benefit? 5 https://t.co/IcsLqVxwVt
2022-06-07 19:52:36 As predicted, FDA Advisory Committee votes 21-0 today to recommend @Novavax EUA
2022-06-07 19:33:32 RT @virusninja: This study is one of the few that benchmarks the host response to #SARSCoV2 against #flu. This enables us to define what m…
2022-06-07 17:01:39 "Ventilation is a key strategy recommended to reduce COVID-19 spread in school settings" —new @CDCMMWR reportSo why aren't we doing that everywhere?https://t.co/mkhKpV9PGL #COVIDisAirborne https://t.co/vA150WKy0n
2022-06-07 16:59:45 @EcoSexuality Hopefully, if the L452 mutation is key, and shared by these 3 variants (BA.2.12.1, BA.4, BA.5)
2022-06-07 16:09:57 Olfactory bulb (comparison with influenza) and transcriptomics of peripheral organs https://t.co/vFWJeTYE9M
2022-06-07 15:44:23 New, important #LongCovid report @ScienceTM: persistent pro-inflammatory biology"These data highlight a molecular mechanism for persistent COVID-19 symptomatology and provide a small animal model to explore future therapeutics."https://t.co/iLQ8dTw8BA @Justin_Frere @virusninja https://t.co/sheH9B5W4v
2022-06-07 15:12:07 "So drink up--but it would be prudent to avoid too many caramel macchiatos while more evidence brews." Excellent editorial succinctly reviews all the data on coffee and outcomes, by @wee_christina https://t.co/olLFERsRmNhttps://t.co/RE8R9RDjGt
2022-06-06 20:25:30 A look at who is getting hospitalized in the US during the BA.2/BA.2.12.1 wave.>
2022-06-06 19:59:32 Maternal asthma and the risk of children with asthmaEvidence for an epigenetically mediated mechanism during in utero exposure https://t.co/OgVfgEjJyN @PNASNews https://t.co/UFGjIzl7pQ
2022-06-06 18:00:02 BA.4 and BA.5 have different mutations than BA.2.12.1 in the spike protein and other parts of the virus (nucleocapsid, ORFs) as shown herehttps://t.co/0dcenIjbZ6https://t.co/cKewJ8ADrw
2022-06-06 16:16:50 Typo: BA.4/BA.5 more immune evasiveness than BA.2.12.1.....
2022-06-06 16:13:03 The graph at the left is weeks behind. On the right, from Minnesota's twin cities, is where we are headed. BA.4/BA.5 has more immune evasiveness than BA.1.12.1, more transmissibility, and more pathogenic in the lab and experimental model https://t.co/x2K0UT1Tqghttps://t.co/JhD6Fhbhe8
2022-06-06 14:34:15 Following one of the worst 1st booster shot uptakes in the world among developed countries, of more than 112 million Americans age 50+, only ~5 million have had a 2nd booster shothttps://t.co/9u80GJOkQl by @joshulick https://t.co/hyDGbbBMDc
2022-06-06 14:21:11 "The coronavirus pandemic has created a mass-disabling event" #LongCovid https://t.co/0urhgtH3zZby @FrancesSSellers
2022-06-06 01:09:20 RT @macroliter: @EricTopol @LizSzabo Yup. I’m quite concerned that 3x mRNA vaccinated folks like me who’ve thus far managed to avoid contra…
2022-06-05 17:51:53 'A complete remission in every single patient is “unheard-of”'Combining genomics diagnosis of mismatch repair deficient + PD-1 immunotherapy led to complete remission of 18 consecutive patients w/ advanced colorectal cancer https://t.co/54yFGoTDoZhttps://t.co/CZsoFHM0Gl #ASCO22 https://t.co/Lqtlir8Nr3
2022-06-05 16:56:49 @moskov Because the have the same spike sequenceThey differ in other parts of the virus https://t.co/92rCNiT9f2
2022-06-05 16:26:55 It's not over, by any means, but the chances of dying from Covid keep declining https://t.co/6Bl6ULPeey
2022-06-05 15:58:18 In case you were wondering if BA.4/5 will outcompete BA.2.12.1, and more.... https://t.co/7Lv7kAyD3j
2022-06-04 16:04:05 6 cases of myocarditis, all recovered, no other safety concernsData clearly meet criteria for EUA and many people have been waiting for a non-mRNA alternative for primary vax or booster https://t.co/tYCbGgCjv1
2022-06-04 15:36:13 A distinct post-Covid phenotype with smell and taste dysfunction is associated with better recovery #LongCovid "This stresses the heterogeneity of post-acute Covid sequelae, each requiring tailored management strategies"https://t.co/nTfTMjTjuihttps://t.co/fz8xaR80te
2022-06-04 14:56:42 The "S" word for the pandemic is subvariants. Who even heard or used this word prior to Omicron's descendants? 6 weeks ago the US was in the best shape since it all started. Then came BA.2, now BA.2.12.1, and next up BA.4, BA.5. https://t.co/CwdlEZMdWJ
2022-06-03 19:18:29 @larrybrilliant Thanks Larry. Wish it could be more optimistic
2022-06-03 17:59:53 Our immune system follows circadian rhythm. A new review @SciImmunology. And why getting Covid vaccines in the morning elicits a better antibody and cellular immune responsehttps://t.co/nqDxy3XYv1 @ScheiermannLab https://t.co/qfmkX4kQ4g
2022-06-03 15:56:32 Just out @SciImmunology Post-vaccination breakthrough infections with Omicron BA.1 provide strong neutralizing activity vs BA.2 (and prior variants) but not vs BA.4/5https://t.co/EyBy7aaEpshttps://t.co/RYhIAwUHj5
2022-06-03 14:27:52 A 59 % higher risk of developing diabetes in post-acute COVID-19 phase versus healthy controls, from pooled analysis from 4 large retrospective studies #LongCovidhttps://t.co/l0MtYPgbROhttps://t.co/fcqNQUuA9b
2022-06-03 04:37:31 7% reduction in cases, week-to-week https://t.co/QPRo6jaOkaI'm certainly not convinced it's peaked, but I never give up hope. And know there will likely be BA.4/5 to contend with and known unknown variants ahead. https://t.co/mhAD8MbYOL
2022-06-03 04:04:39 Could the US BA.2/BA2.12.1 wave have peaked?Hard to know with under-reporting/lack of testing and many regions still in flux, but let's hope it's a good sign https://t.co/PA3FpMKeSI
2022-06-02 18:57:05 "Height may be an unrecognized but biologically plausible risk factor for several common conditions in adults" @PLOSGenetics https://t.co/c0rmnf91RMTall stature associated w/ protection vs atrial fibrillation, cardiovascular conditions but heightened risk (no pun) for others https://t.co/JtaTAQIvj0
2022-06-02 17:58:11 With the US now BA.2.12.1 variant dominant, yesterday there were over 263,000 new confirmed cases reported and 1,247 more people hospitalized for Covidhttps://t.co/QPRo6jaOka
2022-06-02 17:40:50 This may be the 1st report of the liquid biopsy biomarker result predicting immunotherapy response better than a solid (tumor) biopsyhttps://t.co/CahP0OUYDI #cancer @TischCancer @MountSinaiNYC @ChristianRolfo https://t.co/CWxpBKmkRK
2022-06-02 16:53:01 What was the impact of Covid vaccine mandates for increased uptake across multiple countries?A big range, from <
2022-06-02 16:41:19 You'll be seeing a lot more of these headlines, not just for infectious diseases, but also for cancer, autoimmune heart disease, and genetic disordershttps://t.co/SDfsw4g30KMy substack review of this exciting path forwardhttps://t.co/KoEDkEsYrbhttps://t.co/nTmcL5T2DH
2022-06-02 01:19:20 Even with the common rebound issue, it really turned out to be a just-in-time breakthrough, as I wrote about ~6 months agohttps://t.co/lcAtZU4RJW
2022-06-01 22:25:17 More symptoms, disruption with BA.2 than BA.1https://t.co/eTDXmumK7wReinforces: as the virus evolve, it doesn't necessarily become less virulent
2022-06-01 22:25:16 Recently, worse symptoms from BA.2 infections have been documented compared with BA.1below. A new report shows the BA.2 variant replicates more efficiently in the upper airway and lung compared with BA.1https://t.co/GQdm0hJ65w @hkumed https://t.co/g6DzDe0hta
2022-06-01 21:04:30 It's a @NEJM case report, but a groundbreaking one. For a woman with refractory pancreatic cancer, genetically engineered T cells directed towards the KRAS driver mutation achieved substantial tumor regressionhttps://t.co/X7NuoRehtqhttps://t.co/TsGg84GzHa
2022-06-01 20:00:44 A new real-world effectiveness report of Paxlovid during the Omicron wave: in people age 65+ an 81% reduction in death and 67% reduction in hospitalizationshttps://t.co/ZNohKWmTK6@ArbelRonen @ClalitHealth and colleagues https://t.co/MbakbgkbAJ
2022-06-01 18:14:59 The overall sensitivity of Covid detection by trained dogs was 97% and "even reached 100% in asymptomatic individuals" compared to nasopharyngeal swab PCR tests. Overall canine sensitivity vs PCR (97% CI: 91 to 99 versus 84% CI: 74 to 90, p = 0.006), https://t.co/tE2oD6Ecdfhttps://t.co/uC9hDTH9WM
2022-06-01 17:16:25 The mutations our blood cells acquire as we age—clonal hematopoiesis—is the norm, 10% of blood cells for age 70+, with marked reduction of diversity
2022-06-01 14:41:29 Yes, the marked increase in transmissibility of Omicron over Delta was a driving factor. But vaccinations in age 65+ during Omicron were critical: 2-shots reduced deaths by 85% and with a booster there were 96% less deaths https://t.co/8jL05VYudb
2022-06-01 02:37:53 A new @bmj_latest systematic review of 53 studies of boosters and mix and match shows marked benefit of boosters but little difference for mixing (mRNA and adenovirus) vs matching (3 mRNAs)https://t.co/QsoBUwyIhxhttps://t.co/euWoXj3ul8
2022-06-01 02:03:27 And is dominant (>
2022-06-01 02:03:26 The BA.2.12.1 variant is now 59% [95% CI 55,63%] of new cases in the United Stateshttps://t.co/jjl2AnwOWX(It's ~25% more transmissible than BA.2, which it out-competed) https://t.co/S6Uo7GscDh
2022-06-01 01:53:57 Publsihed today @PNASNews Mask wearing significantly reduces #SARSCoV2 community transmission. Analysis of the effect in 92 regions, 6 continents https://t.co/t9lD0KYvTt by @g_leech_ and colleagues https://t.co/I6HxL5fSR0
2022-05-31 18:52:33 Quite a feat:"We report the transplantation of a human liver discarded by all centers, which could be preserved for several days using ex situ normothermic machine perfusion."https://t.co/TQuXIh0ie3@NatureBiotech
2022-05-31 16:59:18 "As of mid-May, more than one-quarter of Americans 65 and older had not had their most recent vaccine dose within a year. And more than half of people in that age group had not been given a shot in the last six months." https://t.co/s2iDznH0x8
2022-05-31 16:27:43 Omicron's lethality rate among seniors was worse than Deltahttps://t.co/DqZooPJKvaThe waning of vaccinations, lack of adequate booster uptake in this high-risk age group were contributory factors
2022-05-31 16:17:14 @CT_Bergstrom @JAMANetworkOpen In agreement. Here are the other graphs from their report. The other issue is pitting models vs doctors when that is not the real world for how medical decisions/prognosis are determined https://t.co/kg8TpWXeOU
2022-05-31 15:34:23 When the machines outperformed 74 oncologists for predicting outcomes in a prospective study of over 2,000 patients with advanced cancer #AIhttps://t.co/UmfjRhZak2 @JAMANetworkOpen https://t.co/5zJSb0qv0g
2022-05-31 15:23:18 "Our findings suggest that even in the context of airborne transmission, approximately 4% of index [Covid] cases in indoor settings would account for 80% of secondary cases"A new analysis of superspreader events and overdispersionhttps://t.co/OsTuZfJHPU
2022-05-31 15:12:13 Pulse oximetry overestimates arterial oxygen saturation in racial minority groups with Covid, leading to lack or delay of therapies. This "occult hypoxemia" may worsen outcomeshttps://t.co/fc9FRQUx1k @JAMAInternalMed https://t.co/QzKwVGwZjh
2022-05-31 14:03:27 Over 2 billion doses of mRNA + nanoparticles has laid the foundation for a new approach to infectious and autoimmune diseases, cancer, genetic disorders, and prevention of heart attackshttps://t.co/KoEDkEsYrb
2022-05-31 01:05:13 Quite the lede"The isolation of CCoV-HuPn-2018 from a child respiratory swab indicates that more coronaviruses are spilling over to humans than previously appreciated."https://t.co/GmUA4P289i @CellCellPress by @veeslerlab https://t.co/RqZd6e9NL4
2022-05-31 00:39:23 RT @gabrieldane: Happening tomorrow, 7p ET. Let’s BLOW THIS UP #medtwitter. Let’s show we can focus our collective energy on making a dent…
2022-05-30 21:36:13 A look at the bright side of the pandemic for decades to comehttps://t.co/KoEDkEsYrb
2022-05-30 17:34:19 "Our study reveals how specific neuron clusters located in diverse regions of the brain relevant to fear and the fight or flight response cause massive changes in leukocyte distribution and function"Elegant work w/ #optogenetics @WolframPoller @IcahnMountSinai @SinaiHeartBlood
2022-05-30 17:27:54 With a great resource that summarizes all the mutations that have changed amino acids and led to impact, with references https://t.co/5WtVC43zvz
2022-05-30 17:15:21 @NatureMedicine "The pandemic is not over, and #SARSCoV2 is spreading at a high level globally. Now is the time to enhance global sequencing capacities, focusing on widening coverage to include previous geographical and population blind spots"https://t.co/yL2xisDH0r@lsubissihttps://t.co/xip3MR762v
2022-05-30 15:33:02 RT @ChasBeekeeper: @EricTopol @AditGinde That’s reassuring and I’m so grateful for having received Evusheld in February. Without additional…
2022-05-30 15:25:37 For the pandemic, "U.S. deaths were 15 percent above normal — a number surpassed by only four other large countries in the same income group: Chile, the Czech Republic, Poland and Romania."https://t.co/mRvXoGktRd @DeniseDSLu @nytgraphics https://t.co/rShmir7w0g
2022-05-30 15:11:09 Paxlovid became a household name in the US during the BA.2 waveDuring the week that ended May 6, prescribers wrote 8,977 scripts of Lagevrio (Molnupiravar) and 118,123 scripts of Paxlovidhttps://t.co/bkCwy9p6kL by @JaredSHopkins
2022-05-30 01:41:34 RT @Bob_Wachter: We’ve been counting on Evusheld to remain a key tool for protecting immunosuppressed people during Omicron. Ir wasn’t a sl…
2022-05-29 21:40:28 First real-world assessment of Evusheld protection for immunompromised people during the Omicron wave:Marked reduction of mortality, hospitalization and infectionshttps://t.co/q59gyiInui @AditGinde https://t.co/zvpGL97JOX
2022-05-29 18:39:28 If you're looking for some inspiration, look no further than @jacindaardern's commencement addresshttps://t.co/I8GJCklHKx)
2022-05-29 15:18:05 "We could have more Warp Speeds — for therapeutics, for ventilation systems, for rapid global provision of vaccine technology."https://t.co/v54dznAqUF by @dwallacewells @nytopinion https://t.co/KxlIHrmYtZ
2022-05-29 02:02:01 I attempted to make a graph to highlight this point of *intrinsic* virulence increasing up to 3 times via diff't (sub)variants during the pandemic, which has been misinterpreted. The point is made below w/data above and the graph has been deleted. https://t.co/eZmw5hAVOa
2022-05-29 01:40:38 @socalsysbio There is confounding of vaccination and prior infection. Adjusting for that, Omicron was thought to be ~25% less virulent than Delta. Subsequent studies for BA.2 and BA.4/5 are summarized in the
2022-05-28 22:41:54 The progression of the virus's fitness throughout the pandemic. Fitness encompasses a lineage's growth, Ro reproduction number, immune-evasiveness and generation time. Graph doesn't include BA.2.12.1 and BA.4/5 which are more fit than BA.2https://t.co/0WY7gW3RtBhttps://t.co/gKvvyYbMOO
2022-05-28 22:14:04 The US current BA.2/BA.2.12.1 wave may be extended by the BA.4/5 variants, owing to their growth advantage and higher fitness, as aptly reviewed here https://t.co/1Fc9uytdv4
2022-05-28 20:14:35 "Odds of infection for those who did not always compared to those who always wore a mask was 66% higher pre-Delta, 53% higher during Delta, declining to 16% higher during Omicron"https://t.co/mXBde7wn6AOmicron's hyper-transmissibility necessitates high- quality masks (KN95/N95) https://t.co/CEtUmz5lXM
2022-05-28 16:49:44 Two countries where the BA.4/BA.5 variants became dominant: the outcomes are quite different@OurWorldInData (Not so easy to extrapolate impact of variants across places w/ marked differences in population demographics, prior/strain of infections, vaccinations, testing, etc) https://t.co/tgfHVsR3qY
2022-05-28 16:26:53 The current BA.2/BA2.12.1 wave is the 2nd highest case burden for the US pandemic
2022-05-28 16:17:41 The immune response induced by Omicron post-vaccination breakthrough infections is blunted compared with Delta breakthrough infections https://t.co/Bf5oDUKWvh @ImmunityCP @MariosKoutsakos @TheDohertyInst @ProfStephenKent and colleagues https://t.co/yWvbd4u3oY
2022-05-28 15:57:39 Prior Covid, unvaccinated, offers limited protection from Omicron infections in contrast with 3-dose vaccination: new report from the California prison system during Omicron wave of ~25,000 cases and >
2022-05-27 20:27:04 "BA.4 and BA.2.12.1 can overcome immunity provided by earlier infections with other Omicron subvariants." "This was unexpected...maybe we should adapt the system of naming"—@houzhouhttps://t.co/D0Ce1VPmsj @Nature by @amymaxmen
2022-05-27 19:56:34 @trvrb @LongDesertTrain @calmarten I provided the source in the threadhttps://t.co/IKqSKtzdR6 which did include the antigenic map below, conveying the same point as the genetic distance, but may be more difficult to interpret for people not familiar with the mutations https://t.co/IgS0piAXdr
2022-05-27 17:27:20 Keep your eyes on theevolutionThe antigenic distance (how our immune system "sees" the virus) from Omicron BA.1 to BA.2.12.1 (the dominant variant is the US now) and to BA.4/5 is pronounced. Note no functional sub-variants of any prior Greek letter VoCs https://t.co/Q2BTBI2OUJ
2022-05-27 17:00:15 + ThisFederal assault gun ban expired in 2004#ThisIsOurLane @ThisIsOurLane https://t.co/yl5qbH49bx
2022-05-27 12:51:57 RT @trishgreenhalgh: This is causing waves among virology Twitter. Bottom line: the pandemic is not over, and it's NOT getting milder.
2022-05-27 12:42:09 RT @Noahpinion: Yes we are
2022-05-27 03:55:04 "The United States has 46 percent of the world’s civilian-owned guns "https://t.co/Hf7fTQoRS3That was as of 2018, and has increased since then
2022-05-27 03:50:47 Confirmed Covid deaths, as of todayUS 1,004,121World 6,284,446https://t.co/gV8kcaeLPK
2022-05-27 03:27:30 American exceptionalismThe United States comprises 4% of the world's population 16% of the world's Covid confirmed deaths 40% of world's guns Only industrialized nation in the world with states making abortion illegal
2022-05-27 02:38:45 @TenTenbrink Thank you!
2022-05-27 02:36:05 Table of the 7 casesThe Omicron high viral load issue, as opposed to Delta when the Paxlovid randomized trials were conducted, may well be the driver of this rebound https://t.co/QGWCtff3sy
2022-05-27 02:33:01 @violetblue Thanks, Violet. I had missed this, completely unacceptable and fulfills your WTF label
2022-05-27 02:29:37 RT @gmleunghku: Thanks @EricTopol for shoutout…I’ve put together a thread here to explain in a little more detail about this and another re…
2022-05-27 02:27:42 Paxlovid relapse insights from 7 individualsHigh viral loads at enrollment and for 17 days
2022-05-27 02:01:54 1st report of real-world effectiveness of Paxlovid in the outpatient setting, BA.2 wave, Hong Kong75% reduced death, 31% reduced hospitalization, 53% reduced adverse outcomesNo impact of vaccination on outcomes
2022-05-26 23:33:48 @antoniottwalter @SystemsVirology More than prevalent. BA.2.12.1 is dominant in the US
2022-05-26 23:26:16 Above is the 2nd example of a new variant (BA.2) being more virulent than a predecessor (BA.1)The first was Delta over AlphaNew data today suggests the Omicron subvariants (BA.4/5, BA.2.12.1) may have more virulence than BA.2
2022-05-26 23:20:02 BA.2.12.1 and BA.4/BA.5 characterized in human lung cells and an experimental model by @SystemsVirology —All 3 Omicron subvariants have enhanced replication in lung cells compared w/ BA.2—BA.4/5 is more pathogenic than BA.2 in animal modelhttps://t.co/TvwlO8ljPJhttps://t.co/gSwzPoatg3
2022-05-26 23:09:37 The immune evasion is more extensive for BA.4/5 than BA.2.12.1 variant, raising the possibility that the former can out-compete the latter. Only one clinically available monoclonal antibody (bebtelovimab) has full potency against these Omicron subvariantshttps://t.co/IKqSKtzdR6https://t.co/6RWSGiGtjw
2022-05-26 19:55:14 @hholdenthorp @juliettekayyem @meghas I could have highlighted every word.Thanks Holden https://t.co/rccOheCQeB
2022-05-26 14:38:22 Head-to-head comparison of immune response, both antibody and cellular, for 4 vaccines: Moderna, Pfizer, Novavax and J&
2022-05-26 14:03:55 "Affinity Escape"Another potential mechanism for #SARSCoV2 immune escape: if a variant has stronger binding to ACE2, it could compete with neutralizing antibodieshttps://t.co/O9ThYVDjWC
2022-05-26 13:47:41 @CarlosdelRio7 @NatureMedicine @zalaly @BCBowe @Biostayan @WUSTLmed Unclear, but certainly worth finding out if it helps
2022-05-26 12:46:33 @ZekeJMiller @ashishkjha Deaths are rising.
2022-05-26 03:14:04 RT @kaitlancollins: Amerie Jo Garza's father, a med aide, says he found out she was one of the victims when he arrived on the scene and was…
2022-05-26 02:10:25 "Only" >
2022-05-25 23:40:14 The J&
2022-05-25 23:36:49 "BA.4/BA.5 are antigenically distinct from previous Omicron variants, particularly BA.1, and are still at a substantial distance from the closely related BA.2."Breakthrough infections help ->
2022-05-25 21:41:41 OWS 2.0 hasn't happened because "we" gave up, very tired, and pretending this is over—when it isn't. Far from it. https://t.co/N5zk6WsPWB
2022-05-25 21:00:26 During the Delta wave in Israel, the importance of hybrid immunity, a booster shot, or prior Covid for protection from infections. In @NEJM today https://t.co/tDjnmxsnSr@MiloLabWIS @WeizmannScience @TechnionLive @IsraelMOH https://t.co/NxFiLtqP29
2022-05-25 18:48:36 @LSteelback @ScienceTM Thanks for your vote of confidence. We have. All these agencies and the @WHCOVIDResponse want to support but there's this entity called Congress that is blocking it = zero funding
2022-05-25 18:32:05 Operation Warp Speed (OWS)1.0 was one of the most important, life-saving programs in US historyAre we foolish enough not to have an OWS 2.0 to get nasal vaccines, pan-sarbecovirus vaccines, and more/better drugs across the goal line?
2022-05-25 18:27:06 Just about every week there is a new, broad neutralizing antibody (bnAb) discovery, like this one, that is variant-proof and would take down all #SARSCoV2, that vaccines could be made to induce, that we're not advancinghttps://t.co/ektcfd0NEN @ScienceTM https://t.co/01xhPBANj2
2022-05-25 17:19:56 RT @chrischirp: This is a really important paper because it looks at risk of long covid and other post covid impacts (eg on kidneys, heart…
2022-05-25 15:55:56 This graph breaks down the risk of BTI by out-patient or hospitalized/ICU. For the common, non-severe breakthrough infections, the risks are still increased during 6-month follow-up for multiple outcomes https://t.co/rEUNf0GBQ8
2022-05-25 15:00:25 Less risk of #LongCovid sequelae with BTI compared with unvaccinated Covid https://t.co/HcygHmYnRF
2022-05-25 15:00:24 BTI relative risk and absolute excess burden at 6 months for death, particularly increased for clot-related, lung sequelae https://t.co/em3KgnPxoM
2022-05-25 15:00:22 Just out @NatureMedicine The natural history of post-vaccine breakthrough infections (BTI) in 33,000 people, >
2022-05-25 14:21:15 freja kirsebom chrischirp he misclassification explanation for these differences in vs hospitalization seems optimistic without clear data to back it up
2022-05-25 13:32:32 he 2 variant s impact on 3 shot reduced protection vs hospitalization after 3 4 months compared with 1 is noteworthy https t co i jon gix
2022-05-25 13:19:34 xhibit for the people who don t think cases are important https t co 3 nsq y
2022-05-25 13:17:25 o infection of 1 and 2 detected by random sampling underlines the need for effective genomic surveillance to reduce the risk of generating o 2 recombinants with novel pathogenic and immunologic properties https t co n r h https t co e64 lrh73
2022-05-25 13:09:54 he 6th 2 12 1 2 wave esterday s over 140 000 new confirmed cases multiply by 7 for real number gt
2022-05-24 23:39:04 chrischirp his gap is more pronounced than previously reported by and concerning hat are your thoughts
2022-05-24 23:28:27 shley an peechless eartbroken urious 20 years since olumbine27 school shootings so far 14 babies not coming ho
2022-05-24 23:26:35 emmcnally xactly hanks for pointing that out
2022-05-24 23:16:26 able https t co 4y ts k or
2022-05-24 23:16:24 ew he ancet nf is eduction in vaccine booster effectiveness vs hospitalization for 2 vs 1 variants at 10 weeks https t co 6r29aba510 14 wks 70 2 vs 85 415 wks 56 5 vs 80 4 ee table below for 95 and text for detailsby freja kirsebom and colleagues https t co m 0t2js
2022-05-24 23:07:24 clairlemon hat kind of country lets their children be massacred at school
2022-05-24 23:06:19 nd now another heinous catastrophehttps t co gq 0w ym
2022-05-24 17:45:41 verall age breakdown and graphic https t co 6i nn fxf
2022-05-24 17:45:40 new on ong ovid supports its very high frequency and particular associated risks of cardiovascular neurologic respiratory diabetes kidney mental health and musculoskeletal involvementhttps t co l6ch h https t co q d h 9
2022-05-24 16:00:07 uke2315yee tell it like it is hen there s good news will post it f you only want happy talk don t follow me
2022-05-24 15:52:39 2 12 1 now dominant is the 58 of new cases gov https t co x ud4 uaov
2022-05-24 15:32:48 he axis has to be expanded for 2 12 1 and 4 5 and further variants to come
2022-05-24 15:12:31 ith maximal exercise aerosol particle emission increased an average of 132 foldhttps t co s i8 9 1 ews hese data not only explain o 2 transmissions during indoor group exercise but also can be used to design better targeted mitigation measures https t co 2 j5e k
2022-05-24 14:25:04 ust published cience agazine rom analysis of gt
2022-05-24 13:48:31 ontrary to the perception that recent variants have become successively milder micron 2 was associated with reporting more symptoms with greater disruption to daily activities than 1 2 vs 1 igure https t co e mum 7w https t co 01h7din m
2022-05-20 08:11:00 CAFIAC FIX
2022-10-28 19:37:55 Long-lived plasma cells: real time, cell-by-cell time stamping of their immune response after vaccinationhttps://t.co/bKWGL3a5rp half-life of ~700 days in the mouse model @SciImmunology @MonashUni https://t.co/vRFXcnB8Jy
2022-10-28 17:21:41 @uche_blackstock I'm not going anywhere, Uché. That's how I first met you
2022-10-28 17:18:01 @Nate_DiCamillo @CellCellPress unlocking the article https://t.co/8OakGeNT0I
2022-10-28 17:08:59 The case for some vigorous physical activity: association with reduced mortality, heart disease and cancer in ~72,000 people, mean age 63, followed ~6 yearshttps://t.co/h6XY9Cqms4@ESC_Journals @uk_biobank @Matthew_Ahmadi_ @M_Stamatakis https://t.co/pzYJf68EsU
2022-10-28 16:54:42 "Compelling evidence for the role of carboxylic acid in guiding the mosquito's preference toward specific people"https://t.co/wredsoM8ux @CellCellPress https://t.co/EvMS4VES25
2022-10-28 16:32:26 via @chrischirp In England, the share of cases (and spurt) of BQ.1.1 and BQ.1 is similar to the USHospital admissions are currently on the way down (for now at least) https://t.co/FmfnifCxAT
2022-10-28 15:15:25 Besides the hopeful sign from France noted yesterday https://t.co/I4ujEQvJgw Region 2 of the US has the highest BQ.1.1/1, particularly New York, where new hospital admits have not shown a recent rise https://t.co/rcWUlpd8dk
2022-10-28 14:55:38 New US Covid genomics: BQ.1.1 and BQ.1 variants now account for 27% of cases, up from 17% a week ago, on a path to be dominant (>
2022-10-27 19:06:02 @BenIsraelow Delighted to do so, especially when it's so impressive and gives us much hope for a far better approach/defense
2022-10-27 18:30:09 Protective efficacy of the spike booster lasted for ~4 months, pan-sarbecovirus, using no adjuvants or replication-deficient or live attenuated virus (like FluMist), elicited broad neutralizing Abs.This is the variant-proof booster we need now to help prevent infections &
2022-10-27 18:16:56 Just published @ScienceMagazine A nasal vaccine booster (after primary vaccination) induces mucosal immunity —IgA, memory B and T cell—against the sarbecovirus family in the experimental modelhttps://t.co/j03xNjIXzhby @VirusesImmunity @tianyangmao and team @YaleIBIO @YaleMed https://t.co/M6LQUZWnlc
2022-10-27 17:44:25 RT @MassMedical: .@EricTopol said it would be a mistake to skip these shots. They still work, they just may not be much of an improvement o…
2022-10-27 17:39:01 Very hopeful signFrance is the 1st country in Europe to see the BQ.1.1 variant dominance (>
2022-10-26 21:05:00 The benefit of vaccination and boosters, along with prior Covid, against Omicron infections, in the California prison systemhttps://t.co/VSwHQIkwrD @NEJM https://t.co/3xg2Yn8DBm
2022-10-26 18:42:07 @Alexander_Tin @CNN @US_FDA @moderna_tx The number of participants in each of the 2 bivalent BA.5 booster independent studies is far greater than the ones Pfizer and Moderna have thus presented (zero) and are quite typical for assessment of neutralizing antibody response throughput the pandemic
2022-10-24 01:51:07 That Singapore's XBB variant wave was not severe, with relaxed mitigation, as @Fiona_M_Russell points out, is v encouraging https://t.co/tJuJ82OOBO —XBB's immune evasion could've ->
2022-10-24 01:21:15 @BagaiDr Many thanks Dr, Bagai!
2022-10-23 18:04:32 It's not a good sign when 3 shots and a breakthrough (BA.1) infection (lower panel) doesn't elicit neutralizing antibodies to some of the new variants (BQ.1.1, XBB, BA.2.75.2) https://t.co/YS9rbTlSGZ
2022-10-23 16:21:46 RT @paula_span: The new bivalent COVID booster: Older folks, a highly vaccinated group, appear less interested in getting it than earlier s…
2022-10-23 16:17:42 @elderconsult I think the likely explanation is a high rate of prior infection, particularly with the Beta variant which seems to provide more cross-immunity than the others
2022-10-22 22:09:29 Thanks for the critique and feedback, @AstroKatie, @choo_ek and many others. A sense of equivalency was never intended. Preventing deaths, hospitalizations and #LongCovid towers over any liabilities.Here's a fixed version https://t.co/hrlYbI8rEI
2022-10-22 20:10:45 For the first year of vaccines, over 20 million lives saved around the world through December 2021 https://t.co/4GnPgEvg7W
2022-10-22 20:10:44 End of July 202291% reduction of deaths, all ages https://t.co/GIPkSo2daH
2022-10-22 20:10:42 Vaccines and boosters save lives. Across all ages.96% reduction of deaths for 2 boosters vs unvaccinatedEnd of May 2022@OurWorldInDatahttps://t.co/UYkn5iszKT
2022-10-22 19:52:45 RT @cshperspectives: Sci comm irony when the first scientist quoted in a story has deleted their twitter account by the time the article ap…
2022-10-22 19:51:15 @JusDayDa @_TheAncientOne_ @MoritzGerstung Yes, that one is good, too. I had summarized it yesterdayhttps://t.co/fS78A4Vrwr
2022-10-22 19:32:01 @JusDayDa @MoritzGerstung Best I've seen is from @yunlong_cao and colleagueshttps://t.co/qWJ4AGtiur
2022-10-22 16:59:36 A review of how #AI has been used during the pandemichttps://t.co/tvjS0ifKFE @PLOSDigiHealth "No clinical trials evaluating any applications impact on patient health" by @RANDCorporation @carlberdahl https://t.co/GeoWpysyyj
2022-10-22 15:31:45 The BQ.1.x wave projection for the US, and calculations for many other countries based on growth advantage vs BA.5, by @MoritzGerstung https://t.co/4TozbJWNLahttps://t.co/wtuI1qLi4r
2022-10-22 14:15:56 Their XBB wave was projected to exceed BA.5.Strong NPI mitigation practices and very high vaccine/booster uptake (a top 10 country) likely contributed https://t.co/93Vd3T3Qg2
2022-10-22 14:05:17 This is very good news.The XBB variant wave in Singapore is in descenthttps://t.co/mZS5FePzrNXBB and BQ.1.1 are 2 of the most immune evasive variants and Singapore was the first country to experience a wave induced by one of them, now letting up https://t.co/DbkSC4OPN7
2022-10-22 01:27:48 @BMcranty @AstroKatie @Sarcasmorator I don't consider major reduction of deaths, hospitalizations, and #LongCovid as "meh"
2022-10-21 22:11:19 @AstroKatie I'm with you. Trying to provide as much balance as possible
2022-10-21 22:08:33 Yesterday's @CDCMMWR report that shows slippage of protection vs hospitalization after 4 months, age 18+, during BA.5 wavehttps://t.co/DRB7tiyffUhttps://t.co/1bTzbZvhAv
2022-10-21 22:05:10 @Sara43347888 The answer is NO. The @sfchronicle headline is terrible and worse than that is to have it behind a paywall. Unacceptable.
2022-10-21 20:45:55 RT @JohnRossMD: In case you missed it, UK COVID minimizer Francois Balloux has deleted his account after amplifying a spectacularly wrong p…
2022-10-21 18:27:42 RT @JReinerMD: Pfizer projects that it will make $32 billion from its COVID vaccine in 2022 and $22 billion from Paxlovid. Their plan to ch…
2022-10-21 17:41:28 The BQ variants and the UShttps://t.co/KEeCny0P9A by @ErinMPrater @FortuneMagazine
2022-10-21 16:36:27 RT @K_G_Andersen: BQ.1(.1)* picking up steam, but still too low to be making a major difference in cases/hospitalizations - follow this tre…
2022-10-21 15:59:15 That's right—Covid boosters aren't for everyone.But for WSJ to print this seriously flawed claim about cardiac deaths in men age 18-39 is inappropriate, to say the least https://t.co/KCox0mhlHGhttps://t.co/NixQ2Uki1R
2022-10-21 14:50:01 What are the #SARSCoV2 variants accounting for US cases?New CDC genomic surveillance updateOn the rise: Predominantly BQ.1 and BQ.1.1 (~17%), also BF.7 (7%), BA.2.75.2On the decline: BA.5, BA.4.6https://t.co/jjl2AnwOWXhttps://t.co/r7i6cYnjSe
2022-10-21 14:37:20 RT @mhornig: Not convinced efforts to avoid #SARSCoV2 infx are worth it? Think #LongCOVID and potential for #MECFS are fantasy? Please list…
2022-10-21 14:20:48 Myalgic encephalomyelitis was first recorded in 1934 in Los Angeles after an outbreak of atypical polio. It has taken nearly a century and #LongCovid to "get needed attention"https://t.co/ryyI15mfnf @NanetteAsimov #mecfs https://t.co/xOYiOk9R2A
2022-10-21 02:54:11 Keep an eye on New York, leading the country with % cases BQ.1.1, bellwether for the next wave https://t.co/vw77IAyHJj (update, first picked up by @JPWeiland) https://t.co/MPJSVvzqEY
2022-10-21 01:50:07 The inversion (next wave) is likely starting by the rise in hospitalizations. Great time for CDC to stop daily tracking https://t.co/RXymG9t41x
2022-10-20 23:56:25 On the imprinting issue, in the Discussion"antibody responses to some Omicron S[spike]-specific epitopes were hindered by prior antigenic exposure" https://t.co/w9oiWH8s5A
2022-10-20 18:57:29 Vaccination alone did not induce neutralizing activity in the nasal mucosa, but that was achieved via breakthrough infections."These observations... .motivate the development and evaluation of a next generation of vaccines administered intranasally." https://t.co/XIaSiKDJ7R
2022-10-20 17:17:31 Also to note that 60%+ max is not the 80%+ protection vs hospitalization that was consistently seen prior to BA.5, (90%+ for Delta and prior strains) and that finding replicates 2 other studies.Underscores the importance and need for a variant-proof, pan-sarbecovirus vaccine
2022-10-20 17:07:07 Why a booster is important to maintain protection from hospitalization: waning immunityNew @CDCMMWR shows the protection vs BA.5 drops down to 37% (2 shots) and 29% (3 shots) after 4 monthshttps://t.co/DRB7tiyffUData are for all ages 18+ https://t.co/Pa0PtdlWIY
2022-10-20 15:30:35 In a prospective cohort of critically ill adults, sequencing the blood (metagenomics) identified the pathogen 99% and predicted sepsis in 74%https://t.co/tQTgyQHSjY@NatureMicrobiol @UCSF @klkalantar and colleagues https://t.co/wx4u4HpqD5
2022-10-20 13:33:04 "Middle-aged people accounted for the biggest losses in life expectancy"https://t.co/czRQeP2WkHMore at "In America and eastern Europe, covid-19 got worse in 2021" https://t.co/SxZup76Cic
2022-10-20 12:47:01 RT @bmj_latest: “This virus is so amenable to taking it down . . . But we’re just not acting like we can do this. And we can.” @EricTopol…
2022-10-20 01:56:23 RT @EricTopol: There's a lot of total BS out there about myocarditis in kids and adolescents. To state facts:1. CDC does NOT decide about…
2022-10-19 22:20:40 For children 5-11 years in males, 2nd dosethe rate is 2.5 per million https://t.co/kXEH3wMsZl
2022-10-19 22:14:25 There's a lot of total BS out there about myocarditis in kids and adolescents. To state facts:1. CDC does NOT decide about Covid vaccines in schools 2. There are no kids dying of myocarditis from the vaccines3. It is very rare, mild 4. The anti-vaxx world has gone beserk
2022-10-19 21:56:45 The BA.4.6 variant accounts for ~12% of US Covid cases (pattern of growth below, left). Its level of immune escape was characterized @NEJM today: 2-3 fold less neutralizing antibodies than BA.5 (below, right)https://t.co/WdRlUvagsW @BarouchLab https://t.co/HCJYiczVfX
2022-10-19 21:06:24 Randomized, placebo-controlled trial of the 2-dose @moderna_tx vaccine in children 6 months to 5 years, during Omicron. Safe in ~4,800 kids
2022-10-19 21:00:25 New @NEJM"Our study indicates that [Pfizer] vaccine-induced myocarditis in adolescents appears to be a rare adverse event [<
2022-10-19 18:00:25 4. No increased risk of miscarriage or other pregnancy complications from vaccination or booster https://t.co/mVFxD3aE8e
2022-10-19 18:00:23 3. Newborn/infant (0-5 months) avoidance of hospitalization by mother's vaccination https://t.co/T2Wut9L6kK
2022-10-19 18:00:21 2. Vaccination protected vs hospitalization vs Delta and Omicron infections with booster (same with ED or urgent care visits)But 57% of expectant mothers have not been vaccinated or had a booster https://t.co/e9BEJwfVse
2022-10-29 19:05:35 The #1 sleuth of life science data manipulation and imaging fraud, @MicrobiomDigest, has analyzed more than 100,000 papers since 2014. She reviews what she's learned and lays out what needs to change https://t.co/AYjYeVcrTP@nytopinionhttps://t.co/gw75OwQZb7
2022-10-29 17:27:33 Q—Before the pandemic, when was the last time an intervention's efficacy and safety was validated in >
2022-10-29 16:27:22 Song of the Cell, @DrSidMukherjee's new book, is an extraordinary work that covers the cell's history and future, along with its mysteries, like he did for genes in The Gene. Reviewed by @DShaywitz @WSJhttps://t.co/ec8WVRk0T6https://t.co/YUSxRINVEb
2022-10-29 15:25:57 A ranking of the immune evasion for the new variantshttps://t.co/1lrjUMGa9X
2022-10-29 15:15:15 An encouraging sign for one of the (if not the) most immune evasive new variantsXBB is dominant in India and Bangladesh without a rise in cases or deaths to datehttps://t.co/kraBgpFU4V and @OurWorldInData https://t.co/oZdLOXtoSI
2022-10-28 19:37:55 Long-lived plasma cells: real time, cell-by-cell time stamping of their immune response after vaccinationhttps://t.co/bKWGL3a5rp half-life of ~700 days in the mouse model @SciImmunology @MonashUni https://t.co/vRFXcnB8Jy
2022-10-28 17:21:41 @uche_blackstock I'm not going anywhere, Uché. That's how I first met you
2022-10-28 17:18:01 @Nate_DiCamillo @CellCellPress unlocking the article https://t.co/8OakGeNT0I
2022-10-28 17:08:59 The case for some vigorous physical activity: association with reduced mortality, heart disease and cancer in ~72,000 people, mean age 63, followed ~6 yearshttps://t.co/h6XY9Cqms4@ESC_Journals @uk_biobank @Matthew_Ahmadi_ @M_Stamatakis https://t.co/pzYJf68EsU
2022-10-28 16:54:42 "Compelling evidence for the role of carboxylic acid in guiding the mosquito's preference toward specific people"https://t.co/wredsoM8ux @CellCellPress https://t.co/EvMS4VES25
2022-10-28 16:32:26 via @chrischirp In England, the share of cases (and spurt) of BQ.1.1 and BQ.1 is similar to the USHospital admissions are currently on the way down (for now at least) https://t.co/FmfnifCxAT
2022-10-28 15:15:25 Besides the hopeful sign from France noted yesterday https://t.co/I4ujEQvJgw Region 2 of the US has the highest BQ.1.1/1, particularly New York, where new hospital admits have not shown a recent rise https://t.co/rcWUlpd8dk
2022-10-28 14:55:38 New US Covid genomics: BQ.1.1 and BQ.1 variants now account for 27% of cases, up from 17% a week ago, on a path to be dominant (>
2022-10-27 19:06:02 @BenIsraelow Delighted to do so, especially when it's so impressive and gives us much hope for a far better approach/defense
2022-10-27 18:30:09 Protective efficacy of the spike booster lasted for ~4 months, pan-sarbecovirus, using no adjuvants or replication-deficient or live attenuated virus (like FluMist), elicited broad neutralizing Abs.This is the variant-proof booster we need now to help prevent infections &
2022-10-27 18:16:56 Just published @ScienceMagazine A nasal vaccine booster (after primary vaccination) induces mucosal immunity —IgA, memory B and T cell—against the sarbecovirus family in the experimental modelhttps://t.co/j03xNjIXzhby @VirusesImmunity @tianyangmao and team @YaleIBIO @YaleMed https://t.co/M6LQUZWnlc
2022-10-27 17:44:25 RT @MassMedical: .@EricTopol said it would be a mistake to skip these shots. They still work, they just may not be much of an improvement o…
2022-10-27 17:39:01 Very hopeful signFrance is the 1st country in Europe to see the BQ.1.1 variant dominance (>
2022-10-26 21:05:00 The benefit of vaccination and boosters, along with prior Covid, against Omicron infections, in the California prison systemhttps://t.co/VSwHQIkwrD @NEJM https://t.co/3xg2Yn8DBm
2022-10-26 18:42:07 @Alexander_Tin @CNN @US_FDA @moderna_tx The number of participants in each of the 2 bivalent BA.5 booster independent studies is far greater than the ones Pfizer and Moderna have thus presented (zero) and are quite typical for assessment of neutralizing antibody response throughput the pandemic
2022-10-24 01:51:07 That Singapore's XBB variant wave was not severe, with relaxed mitigation, as @Fiona_M_Russell points out, is v encouraging https://t.co/tJuJ82OOBO —XBB's immune evasion could've ->
2022-10-24 01:21:15 @BagaiDr Many thanks Dr, Bagai!
2022-10-23 18:04:32 It's not a good sign when 3 shots and a breakthrough (BA.1) infection (lower panel) doesn't elicit neutralizing antibodies to some of the new variants (BQ.1.1, XBB, BA.2.75.2) https://t.co/YS9rbTlSGZ
2022-10-23 16:21:46 RT @paula_span: The new bivalent COVID booster: Older folks, a highly vaccinated group, appear less interested in getting it than earlier s…
2022-10-23 16:17:42 @elderconsult I think the likely explanation is a high rate of prior infection, particularly with the Beta variant which seems to provide more cross-immunity than the others
2022-10-22 22:09:29 Thanks for the critique and feedback, @AstroKatie, @choo_ek and many others. A sense of equivalency was never intended. Preventing deaths, hospitalizations and #LongCovid towers over any liabilities.Here's a fixed version https://t.co/hrlYbI8rEI
2022-10-22 20:10:45 For the first year of vaccines, over 20 million lives saved around the world through December 2021 https://t.co/4GnPgEvg7W
2022-10-22 20:10:44 End of July 202291% reduction of deaths, all ages https://t.co/GIPkSo2daH
2022-10-22 20:10:42 Vaccines and boosters save lives. Across all ages.96% reduction of deaths for 2 boosters vs unvaccinatedEnd of May 2022@OurWorldInDatahttps://t.co/UYkn5iszKT
2022-10-22 19:52:45 RT @cshperspectives: Sci comm irony when the first scientist quoted in a story has deleted their twitter account by the time the article ap…
2022-10-22 19:51:15 @JusDayDa @_TheAncientOne_ @MoritzGerstung Yes, that one is good, too. I had summarized it yesterdayhttps://t.co/fS78A4Vrwr
2022-10-22 19:32:01 @JusDayDa @MoritzGerstung Best I've seen is from @yunlong_cao and colleagueshttps://t.co/qWJ4AGtiur
2022-10-22 16:59:36 A review of how #AI has been used during the pandemichttps://t.co/tvjS0ifKFE @PLOSDigiHealth "No clinical trials evaluating any applications impact on patient health" by @RANDCorporation @carlberdahl https://t.co/GeoWpysyyj
2022-10-22 15:31:45 The BQ.1.x wave projection for the US, and calculations for many other countries based on growth advantage vs BA.5, by @MoritzGerstung https://t.co/4TozbJWNLahttps://t.co/wtuI1qLi4r
2022-10-22 14:15:56 Their XBB wave was projected to exceed BA.5.Strong NPI mitigation practices and very high vaccine/booster uptake (a top 10 country) likely contributed https://t.co/93Vd3T3Qg2
2022-10-22 14:05:17 This is very good news.The XBB variant wave in Singapore is in descenthttps://t.co/mZS5FePzrNXBB and BQ.1.1 are 2 of the most immune evasive variants and Singapore was the first country to experience a wave induced by one of them, now letting up https://t.co/DbkSC4OPN7
2022-10-22 01:27:48 @BMcranty @AstroKatie @Sarcasmorator I don't consider major reduction of deaths, hospitalizations, and #LongCovid as "meh"
2022-10-21 22:11:19 @AstroKatie I'm with you. Trying to provide as much balance as possible
2022-10-21 22:08:33 Yesterday's @CDCMMWR report that shows slippage of protection vs hospitalization after 4 months, age 18+, during BA.5 wavehttps://t.co/DRB7tiyffUhttps://t.co/1bTzbZvhAv
2022-10-21 22:05:10 @Sara43347888 The answer is NO. The @sfchronicle headline is terrible and worse than that is to have it behind a paywall. Unacceptable.
2022-10-21 20:45:55 RT @JohnRossMD: In case you missed it, UK COVID minimizer Francois Balloux has deleted his account after amplifying a spectacularly wrong p…
2022-10-21 18:27:42 RT @JReinerMD: Pfizer projects that it will make $32 billion from its COVID vaccine in 2022 and $22 billion from Paxlovid. Their plan to ch…
2022-10-21 17:41:28 The BQ variants and the UShttps://t.co/KEeCny0P9A by @ErinMPrater @FortuneMagazine
2022-10-21 16:36:27 RT @K_G_Andersen: BQ.1(.1)* picking up steam, but still too low to be making a major difference in cases/hospitalizations - follow this tre…
2022-10-21 15:59:15 That's right—Covid boosters aren't for everyone.But for WSJ to print this seriously flawed claim about cardiac deaths in men age 18-39 is inappropriate, to say the least https://t.co/KCox0mhlHGhttps://t.co/NixQ2Uki1R
2022-10-21 14:50:01 What are the #SARSCoV2 variants accounting for US cases?New CDC genomic surveillance updateOn the rise: Predominantly BQ.1 and BQ.1.1 (~17%), also BF.7 (7%), BA.2.75.2On the decline: BA.5, BA.4.6https://t.co/jjl2AnwOWXhttps://t.co/r7i6cYnjSe
2022-10-21 14:37:20 RT @mhornig: Not convinced efforts to avoid #SARSCoV2 infx are worth it? Think #LongCOVID and potential for #MECFS are fantasy? Please list…
2022-10-21 14:20:48 Myalgic encephalomyelitis was first recorded in 1934 in Los Angeles after an outbreak of atypical polio. It has taken nearly a century and #LongCovid to "get needed attention"https://t.co/ryyI15mfnf @NanetteAsimov #mecfs https://t.co/xOYiOk9R2A
2022-10-21 02:54:11 Keep an eye on New York, leading the country with % cases BQ.1.1, bellwether for the next wave https://t.co/vw77IAyHJj (update, first picked up by @JPWeiland) https://t.co/MPJSVvzqEY
2022-10-21 01:50:07 The inversion (next wave) is likely starting by the rise in hospitalizations. Great time for CDC to stop daily tracking https://t.co/RXymG9t41x
2022-10-20 23:56:25 On the imprinting issue, in the Discussion"antibody responses to some Omicron S[spike]-specific epitopes were hindered by prior antigenic exposure" https://t.co/w9oiWH8s5A
2022-10-20 18:57:29 Vaccination alone did not induce neutralizing activity in the nasal mucosa, but that was achieved via breakthrough infections."These observations... .motivate the development and evaluation of a next generation of vaccines administered intranasally." https://t.co/XIaSiKDJ7R
2022-10-20 17:17:31 Also to note that 60%+ max is not the 80%+ protection vs hospitalization that was consistently seen prior to BA.5, (90%+ for Delta and prior strains) and that finding replicates 2 other studies.Underscores the importance and need for a variant-proof, pan-sarbecovirus vaccine
2022-10-20 17:07:07 Why a booster is important to maintain protection from hospitalization: waning immunityNew @CDCMMWR shows the protection vs BA.5 drops down to 37% (2 shots) and 29% (3 shots) after 4 monthshttps://t.co/DRB7tiyffUData are for all ages 18+ https://t.co/Pa0PtdlWIY
2022-10-20 15:30:35 In a prospective cohort of critically ill adults, sequencing the blood (metagenomics) identified the pathogen 99% and predicted sepsis in 74%https://t.co/tQTgyQHSjY@NatureMicrobiol @UCSF @klkalantar and colleagues https://t.co/wx4u4HpqD5
2022-10-20 13:33:04 "Middle-aged people accounted for the biggest losses in life expectancy"https://t.co/czRQeP2WkHMore at "In America and eastern Europe, covid-19 got worse in 2021" https://t.co/SxZup76Cic
2022-10-20 12:47:01 RT @bmj_latest: “This virus is so amenable to taking it down . . . But we’re just not acting like we can do this. And we can.” @EricTopol…
2022-10-20 01:56:23 RT @EricTopol: There's a lot of total BS out there about myocarditis in kids and adolescents. To state facts:1. CDC does NOT decide about…
2022-10-19 22:20:40 For children 5-11 years in males, 2nd dosethe rate is 2.5 per million https://t.co/kXEH3wMsZl
2022-10-19 22:14:25 There's a lot of total BS out there about myocarditis in kids and adolescents. To state facts:1. CDC does NOT decide about Covid vaccines in schools 2. There are no kids dying of myocarditis from the vaccines3. It is very rare, mild 4. The anti-vaxx world has gone beserk
2022-10-19 21:56:45 The BA.4.6 variant accounts for ~12% of US Covid cases (pattern of growth below, left). Its level of immune escape was characterized @NEJM today: 2-3 fold less neutralizing antibodies than BA.5 (below, right)https://t.co/WdRlUvagsW @BarouchLab https://t.co/HCJYiczVfX
2022-10-19 21:06:24 Randomized, placebo-controlled trial of the 2-dose @moderna_tx vaccine in children 6 months to 5 years, during Omicron. Safe in ~4,800 kids
2022-10-19 21:00:25 New @NEJM"Our study indicates that [Pfizer] vaccine-induced myocarditis in adolescents appears to be a rare adverse event [<
2022-10-19 18:00:25 4. No increased risk of miscarriage or other pregnancy complications from vaccination or booster https://t.co/mVFxD3aE8e
2022-10-19 18:00:23 3. Newborn/infant (0-5 months) avoidance of hospitalization by mother's vaccination https://t.co/T2Wut9L6kK
2022-10-19 18:00:21 2. Vaccination protected vs hospitalization vs Delta and Omicron infections with booster (same with ED or urgent care visits)But 57% of expectant mothers have not been vaccinated or had a booster https://t.co/e9BEJwfVse
2022-11-18 00:42:08 By current variant growth advantage patterns, the next couple of months in the US will be BQ.1.x dominated. Bivalent boosters will help protect
2022-11-17 23:56:45 A new report confirms the immune escape of the BQ.1.1 variant, along with BA.4.6 &
2022-11-17 23:26:54 We still don't have a way to diagnosis chronic traumatic encephalopathy (CTE) in people who are alive, but may be getting closer https://t.co/SftRQR7TWD by @el_belson @NYTSports https://t.co/BTh6oXUxRg
2022-11-17 21:47:06 RT @rowlsmanthorpe: Long covid has wrecked my life It’s bad, very bad. But you knew that already I want to tell you a hopeful story. A st…
2022-11-17 17:33:41 RT @linseymarr: You get a 2-for-1 with filtration. It removes virus from the air and PM2.5 that is associated with an increased risk of inf…
2022-11-17 17:28:45 RT @Aiims1742: Important #OpenAccess paper in @Cancer_Cell from @CharlesSwanton &
2022-11-17 17:09:54 Strong evidence that particulate matter air pollution (ambient PM2.5) increases the risk of Covid infection, a systematic analysis https://t.co/RueG44Hk2m @MonashUni https://t.co/kpREoqJVPi
2022-11-17 15:46:50 About 1 in 5 of us have an APOE4 gene variant, the #1 genetic risk factor for Alzheimer's disease. But the mechanism for brain injury was a mystery, now getting unraveled (cholesterol processing by oligodendrocytes) https://t.co/gIpGt0CA28 @nature https://t.co/hbmdpO6R3thttps://t.co/4zFZIhUTCI
2022-11-17 01:27:50 @amitsurg Because they do. That's mostly related to the excess of rebound after Paxlovid
2022-11-17 00:58:05 We've (re-)learned a few important lessons from the Paxlovid rebound experience about randomized trials and real world evidence Reviewed here https://t.co/jmT9vIipg9
2022-11-16 19:46:41 The Paxlovid rebound story New data reviewed in the 16 November daily briefing of Ground Truths https://t.co/jmT9vIipg9
2022-11-16 17:48:15 The US Covid death rate (7-day average) drops below 300 for the first time since June 2022. Lowest since pandemic began was 222 in July 2021. https://t.co/Cze8bZgtVrhttps://t.co/uxGosRY1KO
2022-11-16 17:14:12 Immunotherapy can induce myocarditis but the mechanism has been poorly understood. A new report @nature today supports the culprit auto-antigen role of α-myosin and cytotoxic T-cells directed to it https://t.co/uPRUQBbkVh by @MargaretAxelrod @BalkoLab https://t.co/vWZP1IcW19
2022-11-16 16:37:07 Humidity (indoor, relative) is associated with outcomes of Covid infections, a population-based study in 121 countries https://t.co/dWMmyMfBSLhttps://t.co/hW7Jq1mhdo
2022-11-16 01:17:21 RT @PeterHotez: Important and well-conducted study by @EricTopol My take: even though rebound is real and significant, in my conversation…
2022-11-15 23:33:25 For the people pointing out that @POTUS, @CDCDirector and Tony Fauci all had Paxlovid rebound, that's why you do prospective, systematic studies. We've learned that "rebound" also occurs without Paxlovid and that anecdotes/twitter are not representative of the real world
2022-11-15 20:14:34 Each participant did rapid antigen testing every other day through day 15, symptom surveys through day 17, and are being followed for 6 months https://t.co/8bDtswdytR
2022-11-15 20:00:32 The event curves for Paxlovid treated compared with controls https://t.co/2ykeOuBUAX
2022-11-15 19:56:25 Our prospective Paxlovid rebound study with controls preprint is posted By symptoms: ~12% rebound (19% Pax vs 7% controls) By positive testing: ~5% rebound (14% Pax vs 9% controls) Much lower than many estimates https://t.co/czeGEYIJvA by @JayPandit @michaelmina_lab @ScrippsRTI
2022-11-15 16:11:35 Start of new waves in South Korea and Japan, having sustained recent BA.5 waves and this variant still accounts for most new casesThe pandemic isn't over https://t.co/DhwWhZ4CJi
2022-11-15 16:01:28 Here's the article. A potential path to preventing brain tissue from dying https://t.co/ODGuD8X8iy
2022-11-15 00:48:03 Today's pandemic briefing on new booster data and the thick soup of new variantshttps://t.co/LA3nl6FxSx
2022-11-14 17:22:13 RT @danrdanny: Excited to see our work on 3-hour genome sequencing highlighted here! If you think this is interesting we have a bench scien…
2022-11-14 17:04:44 The potential for detecting heart dysfunction (ejection fraction <
2022-11-14 14:37:14 RT @EricTopol: Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so m…
2022-11-14 14:28:16 In aggregate, solid evidence that the bivalent booster elicits a strong and broadened neutralizing antibody immune response. Yet, less than 27% of Americans 65+, the have had it and poor uptake across all age groupshttps://t.co/V5Xlj3cKln
2022-11-14 14:28:15https://t.co/fJbLUdcYJdCoverage @statnews by @matthewherper w/ @SutharLab, whose results were replicated by the new data (Table)
2022-11-14 12:00:01 Moderna BA.5 bivalent booster results announced (via @moderna_tx press release)—largest study to date of >
2022-11-18 00:42:08 By current variant growth advantage patterns, the next couple of months in the US will be BQ.1.x dominated. Bivalent boosters will help protect
2022-11-17 23:56:45 A new report confirms the immune escape of the BQ.1.1 variant, along with BA.4.6 &
2022-11-17 23:26:54 We still don't have a way to diagnosis chronic traumatic encephalopathy (CTE) in people who are alive, but may be getting closer https://t.co/SftRQR7TWD by @el_belson @NYTSports https://t.co/BTh6oXUxRg
2022-11-17 21:47:06 RT @rowlsmanthorpe: Long covid has wrecked my life It’s bad, very bad. But you knew that already I want to tell you a hopeful story. A st…
2022-11-17 17:33:41 RT @linseymarr: You get a 2-for-1 with filtration. It removes virus from the air and PM2.5 that is associated with an increased risk of inf…
2022-11-17 17:28:45 RT @Aiims1742: Important #OpenAccess paper in @Cancer_Cell from @CharlesSwanton &
2022-11-17 17:09:54 Strong evidence that particulate matter air pollution (ambient PM2.5) increases the risk of Covid infection, a systematic analysis https://t.co/RueG44Hk2m @MonashUni https://t.co/kpREoqJVPi
2022-11-17 15:46:50 About 1 in 5 of us have an APOE4 gene variant, the #1 genetic risk factor for Alzheimer's disease. But the mechanism for brain injury was a mystery, now getting unraveled (cholesterol processing by oligodendrocytes) https://t.co/gIpGt0CA28 @nature https://t.co/hbmdpO6R3thttps://t.co/4zFZIhUTCI
2022-11-17 01:27:50 @amitsurg Because they do. That's mostly related to the excess of rebound after Paxlovid
2022-11-17 00:58:05 We've (re-)learned a few important lessons from the Paxlovid rebound experience about randomized trials and real world evidence Reviewed here https://t.co/jmT9vIipg9
2022-11-16 19:46:41 The Paxlovid rebound story New data reviewed in the 16 November daily briefing of Ground Truths https://t.co/jmT9vIipg9
2022-11-16 17:48:15 The US Covid death rate (7-day average) drops below 300 for the first time since June 2022. Lowest since pandemic began was 222 in July 2021. https://t.co/Cze8bZgtVrhttps://t.co/uxGosRY1KO
2022-11-16 17:14:12 Immunotherapy can induce myocarditis but the mechanism has been poorly understood. A new report @nature today supports the culprit auto-antigen role of α-myosin and cytotoxic T-cells directed to it https://t.co/uPRUQBbkVh by @MargaretAxelrod @BalkoLab https://t.co/vWZP1IcW19
2022-11-16 16:37:07 Humidity (indoor, relative) is associated with outcomes of Covid infections, a population-based study in 121 countries https://t.co/dWMmyMfBSLhttps://t.co/hW7Jq1mhdo
2022-11-16 01:17:21 RT @PeterHotez: Important and well-conducted study by @EricTopol My take: even though rebound is real and significant, in my conversation…
2022-11-15 23:33:25 For the people pointing out that @POTUS, @CDCDirector and Tony Fauci all had Paxlovid rebound, that's why you do prospective, systematic studies. We've learned that "rebound" also occurs without Paxlovid and that anecdotes/twitter are not representative of the real world
2022-11-15 20:14:34 Each participant did rapid antigen testing every other day through day 15, symptom surveys through day 17, and are being followed for 6 months https://t.co/8bDtswdytR
2022-11-15 20:00:32 The event curves for Paxlovid treated compared with controls https://t.co/2ykeOuBUAX
2022-11-15 19:56:25 Our prospective Paxlovid rebound study with controls preprint is posted By symptoms: ~12% rebound (19% Pax vs 7% controls) By positive testing: ~5% rebound (14% Pax vs 9% controls) Much lower than many estimates https://t.co/czeGEYIJvA by @JayPandit @michaelmina_lab @ScrippsRTI
2022-11-15 16:11:35 Start of new waves in South Korea and Japan, having sustained recent BA.5 waves and this variant still accounts for most new casesThe pandemic isn't over https://t.co/DhwWhZ4CJi
2022-11-15 16:01:28 Here's the article. A potential path to preventing brain tissue from dying https://t.co/ODGuD8X8iy
2022-11-15 00:48:03 Today's pandemic briefing on new booster data and the thick soup of new variantshttps://t.co/LA3nl6FxSx
2022-11-14 17:22:13 RT @danrdanny: Excited to see our work on 3-hour genome sequencing highlighted here! If you think this is interesting we have a bench scien…
2022-11-14 17:04:44 The potential for detecting heart dysfunction (ejection fraction <
2022-11-14 14:37:14 RT @EricTopol: Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so m…
2022-11-14 14:28:16 In aggregate, solid evidence that the bivalent booster elicits a strong and broadened neutralizing antibody immune response. Yet, less than 27% of Americans 65+, the have had it and poor uptake across all age groupshttps://t.co/V5Xlj3cKln
2022-11-14 14:28:15https://t.co/fJbLUdcYJdCoverage @statnews by @matthewherper w/ @SutharLab, whose results were replicated by the new data (Table)
2022-11-14 12:00:01 Moderna BA.5 bivalent booster results announced (via @moderna_tx press release)—largest study to date of >
2022-11-19 00:57:34 This poses a major concern for immunocompromised who have benefited from Evusheld (preventive) &
2022-11-19 00:57:33 The BQ.1.1 variant, as compared with many of the other new variants, is resistant to all clinically used monoclonal antibodies. BQ.1/BQ.1.1 are now the dominant variants in the United States https://t.co/PCFPSGF2uy @TheLancetInfDis https://t.co/dHucxoGokC
2022-11-18 21:17:45 Good news: 1st drug to alter the course of Type 1 diabetes in 100 years approved by @US_FDA Bad news: it costs ~$200,000/14-day treatment
2022-11-18 20:40:04 @legalnomads BA.1 bivalent induces about half as much neutralizing antibodies vs BA.5 as the BA.5 bivalent (live virus assays), both better than original booster. Whether that translates to any difference clinically is unclear.
2022-11-18 20:12:01 The bivalent BA.1 booster is being use in many countries around the world, but data are limited compared with the original (WT) booster against BA.5. New today: doubling of neutralizing antibodies https://t.co/M2YUB5wpH4 (BA.5 bivalent was ~3-5X WT in several recent studies) https://t.co/xYwnfcXkm6
2022-11-18 18:44:04 How to improve science discovery and productivity? Not just about money (see graph below): funding fast, bets on talent/people, take risk, think big https://t.co/HEAXu2L87H by @greg_ip w/ @patrickc @tylercowen @pdhsu https://t.co/7O6qplOf9C
2022-11-18 18:01:46 @KMunoz46 Correct. That's why there's no good explanation
2022-11-18 17:44:15 RT @ElinSilveous: “Foreign rivals have raced ahead in approving long-awaited nasal-spray vaccines, including one invented in St. Louis, cre…
2022-11-18 17:27:39 Does going to @NFL games increase risk of Covid? https://t.co/UzghLiDCgT Interesting findings of an association in the 14-21 day postgame period when >
2022-11-18 15:54:32 A systematic review of Covid vaccines for kids age 5 to 11 (30 studies) Effectiveness 75% vs hospitalization
2022-11-18 15:45:27 @TopherSpiro46 @AshishKJha46 I know, Topher. Absolutely no reason for refusal of Congress and failure to fund. Appreciate @ashishkjha's strong advocacy
2022-11-18 14:58:07 An explainer for why the US is not pursuing nasal vaccines. TLDR: there is no good explanation https://t.co/Ih6ypzOva7 by @benjmueller w/ @VirusesImmunity @florian_krammer
2022-11-18 03:51:13 @lainemartin1 Very appreciative of your note!
2022-11-18 03:33:22 Refers to BQ.1.1 (see blue arrow)
2022-11-18 03:32:12 New data for why a bivalent booster will help: "These data suggest the bivalent BA.4/5 vaccine is more immunogenic than the original ...vaccine against circulating Omicron sublineages, including BQ.1.1 that is becoming prevalent globally." https://t.co/wAoTyur6be Get boosted! https://t.co/j21g0bELIp
2022-11-18 00:42:08 By current variant growth advantage patterns, the next couple of months in the US will be BQ.1.x dominated. Bivalent boosters will help protect
2022-11-17 23:56:45 A new report confirms the immune escape of the BQ.1.1 variant, along with BA.4.6 &
2022-11-17 23:26:54 We still don't have a way to diagnosis chronic traumatic encephalopathy (CTE) in people who are alive, but may be getting closer https://t.co/SftRQR7TWD by @el_belson @NYTSports https://t.co/BTh6oXUxRg
2022-11-17 21:47:06 RT @rowlsmanthorpe: Long covid has wrecked my life It’s bad, very bad. But you knew that already I want to tell you a hopeful story. A st…
2022-11-17 17:33:41 RT @linseymarr: You get a 2-for-1 with filtration. It removes virus from the air and PM2.5 that is associated with an increased risk of inf…
2022-11-17 17:28:45 RT @Aiims1742: Important #OpenAccess paper in @Cancer_Cell from @CharlesSwanton &
2022-11-17 17:09:54 Strong evidence that particulate matter air pollution (ambient PM2.5) increases the risk of Covid infection, a systematic analysis https://t.co/RueG44Hk2m @MonashUni https://t.co/kpREoqJVPi
2022-11-17 15:46:50 About 1 in 5 of us have an APOE4 gene variant, the #1 genetic risk factor for Alzheimer's disease. But the mechanism for brain injury was a mystery, now getting unraveled (cholesterol processing by oligodendrocytes) https://t.co/gIpGt0CA28 @nature https://t.co/hbmdpO6R3thttps://t.co/4zFZIhUTCI
2022-11-17 01:27:50 @amitsurg Because they do. That's mostly related to the excess of rebound after Paxlovid
2022-11-17 00:58:05 We've (re-)learned a few important lessons from the Paxlovid rebound experience about randomized trials and real world evidence Reviewed here https://t.co/jmT9vIipg9
2022-11-16 19:46:41 The Paxlovid rebound story New data reviewed in the 16 November daily briefing of Ground Truths https://t.co/jmT9vIipg9
2022-11-16 17:48:15 The US Covid death rate (7-day average) drops below 300 for the first time since June 2022. Lowest since pandemic began was 222 in July 2021. https://t.co/Cze8bZgtVrhttps://t.co/uxGosRY1KO
2022-11-16 17:14:12 Immunotherapy can induce myocarditis but the mechanism has been poorly understood. A new report @nature today supports the culprit auto-antigen role of α-myosin and cytotoxic T-cells directed to it https://t.co/uPRUQBbkVh by @MargaretAxelrod @BalkoLab https://t.co/vWZP1IcW19
2022-11-16 16:37:07 Humidity (indoor, relative) is associated with outcomes of Covid infections, a population-based study in 121 countries https://t.co/dWMmyMfBSLhttps://t.co/hW7Jq1mhdo
2022-11-16 01:17:21 RT @PeterHotez: Important and well-conducted study by @EricTopol My take: even though rebound is real and significant, in my conversation…
2022-11-15 23:33:25 For the people pointing out that @POTUS, @CDCDirector and Tony Fauci all had Paxlovid rebound, that's why you do prospective, systematic studies. We've learned that "rebound" also occurs without Paxlovid and that anecdotes/twitter are not representative of the real world
2022-11-15 20:14:34 Each participant did rapid antigen testing every other day through day 15, symptom surveys through day 17, and are being followed for 6 months https://t.co/8bDtswdytR
2022-11-15 20:00:32 The event curves for Paxlovid treated compared with controls https://t.co/2ykeOuBUAX
2022-11-15 19:56:25 Our prospective Paxlovid rebound study with controls preprint is posted By symptoms: ~12% rebound (19% Pax vs 7% controls) By positive testing: ~5% rebound (14% Pax vs 9% controls) Much lower than many estimates https://t.co/czeGEYIJvA by @JayPandit @michaelmina_lab @ScrippsRTI
2022-11-15 16:11:35 Start of new waves in South Korea and Japan, having sustained recent BA.5 waves and this variant still accounts for most new casesThe pandemic isn't over https://t.co/DhwWhZ4CJi
2022-11-15 16:01:28 Here's the article. A potential path to preventing brain tissue from dying https://t.co/ODGuD8X8iy
2022-11-15 00:48:03 Today's pandemic briefing on new booster data and the thick soup of new variantshttps://t.co/LA3nl6FxSx
2022-11-14 17:22:13 RT @danrdanny: Excited to see our work on 3-hour genome sequencing highlighted here! If you think this is interesting we have a bench scien…
2022-11-14 17:04:44 The potential for detecting heart dysfunction (ejection fraction <
2022-11-14 14:37:14 RT @EricTopol: Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so m…
2022-11-14 14:28:16 In aggregate, solid evidence that the bivalent booster elicits a strong and broadened neutralizing antibody immune response. Yet, less than 27% of Americans 65+, the have had it and poor uptake across all age groupshttps://t.co/V5Xlj3cKln
2022-11-14 14:28:15https://t.co/fJbLUdcYJdCoverage @statnews by @matthewherper w/ @SutharLab, whose results were replicated by the new data (Table)
2022-11-14 12:00:01 Moderna BA.5 bivalent booster results announced (via @moderna_tx press release)—largest study to date of >
2022-11-19 19:46:26 My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SARSCoV2 variant with a marked increase in immune evasion not to have induced a wave. https://t.co/DqMJ7LAALu
2022-11-19 15:20:02 I thought that many bytes should be named helluva but the new name is quetta https://t.co/d77lA6LTc2
2022-11-19 00:57:34 This poses a major concern for immunocompromised who have benefited from Evusheld (preventive) &
2022-11-19 00:57:33 The BQ.1.1 variant, as compared with many of the other new variants, is resistant to all clinically used monoclonal antibodies. BQ.1/BQ.1.1 are now the dominant variants in the United States https://t.co/PCFPSGF2uy @TheLancetInfDis https://t.co/dHucxoGokC
2022-11-18 21:17:45 Good news: 1st drug to alter the course of Type 1 diabetes in 100 years approved by @US_FDA Bad news: it costs ~$200,000/14-day treatment
2022-11-18 20:40:04 @legalnomads BA.1 bivalent induces about half as much neutralizing antibodies vs BA.5 as the BA.5 bivalent (live virus assays), both better than original booster. Whether that translates to any difference clinically is unclear.
2022-11-18 20:12:01 The bivalent BA.1 booster is being use in many countries around the world, but data are limited compared with the original (WT) booster against BA.5. New today: doubling of neutralizing antibodies https://t.co/M2YUB5wpH4 (BA.5 bivalent was ~3-5X WT in several recent studies) https://t.co/xYwnfcXkm6
2022-11-18 18:44:04 How to improve science discovery and productivity? Not just about money (see graph below): funding fast, bets on talent/people, take risk, think big https://t.co/HEAXu2L87H by @greg_ip w/ @patrickc @tylercowen @pdhsu https://t.co/7O6qplOf9C
2022-11-18 18:01:46 @KMunoz46 Correct. That's why there's no good explanation
2022-11-18 17:44:15 RT @ElinSilveous: “Foreign rivals have raced ahead in approving long-awaited nasal-spray vaccines, including one invented in St. Louis, cre…
2022-11-18 17:27:39 Does going to @NFL games increase risk of Covid? https://t.co/UzghLiDCgT Interesting findings of an association in the 14-21 day postgame period when >
2022-11-18 15:54:32 A systematic review of Covid vaccines for kids age 5 to 11 (30 studies) Effectiveness 75% vs hospitalization
2022-11-18 15:45:27 @TopherSpiro46 @AshishKJha46 I know, Topher. Absolutely no reason for refusal of Congress and failure to fund. Appreciate @ashishkjha's strong advocacy
2022-11-18 14:58:07 An explainer for why the US is not pursuing nasal vaccines. TLDR: there is no good explanation https://t.co/Ih6ypzOva7 by @benjmueller w/ @VirusesImmunity @florian_krammer
2022-11-18 03:51:13 @lainemartin1 Very appreciative of your note!
2022-11-18 03:33:22 Refers to BQ.1.1 (see blue arrow)
2022-11-18 03:32:12 New data for why a bivalent booster will help: "These data suggest the bivalent BA.4/5 vaccine is more immunogenic than the original ...vaccine against circulating Omicron sublineages, including BQ.1.1 that is becoming prevalent globally." https://t.co/wAoTyur6be Get boosted! https://t.co/j21g0bELIp
2022-11-18 00:42:08 By current variant growth advantage patterns, the next couple of months in the US will be BQ.1.x dominated. Bivalent boosters will help protect
2022-11-17 23:56:45 A new report confirms the immune escape of the BQ.1.1 variant, along with BA.4.6 &
2022-11-17 23:26:54 We still don't have a way to diagnosis chronic traumatic encephalopathy (CTE) in people who are alive, but may be getting closer https://t.co/SftRQR7TWD by @el_belson @NYTSports https://t.co/BTh6oXUxRg
2022-11-17 21:47:06 RT @rowlsmanthorpe: Long covid has wrecked my life It’s bad, very bad. But you knew that already I want to tell you a hopeful story. A st…
2022-11-17 17:33:41 RT @linseymarr: You get a 2-for-1 with filtration. It removes virus from the air and PM2.5 that is associated with an increased risk of inf…
2022-11-17 17:28:45 RT @Aiims1742: Important #OpenAccess paper in @Cancer_Cell from @CharlesSwanton &
2022-11-17 17:09:54 Strong evidence that particulate matter air pollution (ambient PM2.5) increases the risk of Covid infection, a systematic analysis https://t.co/RueG44Hk2m @MonashUni https://t.co/kpREoqJVPi
2022-11-17 15:46:50 About 1 in 5 of us have an APOE4 gene variant, the #1 genetic risk factor for Alzheimer's disease. But the mechanism for brain injury was a mystery, now getting unraveled (cholesterol processing by oligodendrocytes) https://t.co/gIpGt0CA28 @nature https://t.co/hbmdpO6R3thttps://t.co/4zFZIhUTCI
2022-11-17 01:27:50 @amitsurg Because they do. That's mostly related to the excess of rebound after Paxlovid
2022-11-17 00:58:05 We've (re-)learned a few important lessons from the Paxlovid rebound experience about randomized trials and real world evidence Reviewed here https://t.co/jmT9vIipg9
2022-11-16 19:46:41 The Paxlovid rebound story New data reviewed in the 16 November daily briefing of Ground Truths https://t.co/jmT9vIipg9
2022-11-16 17:48:15 The US Covid death rate (7-day average) drops below 300 for the first time since June 2022. Lowest since pandemic began was 222 in July 2021. https://t.co/Cze8bZgtVrhttps://t.co/uxGosRY1KO
2022-11-16 17:14:12 Immunotherapy can induce myocarditis but the mechanism has been poorly understood. A new report @nature today supports the culprit auto-antigen role of α-myosin and cytotoxic T-cells directed to it https://t.co/uPRUQBbkVh by @MargaretAxelrod @BalkoLab https://t.co/vWZP1IcW19
2022-11-16 16:37:07 Humidity (indoor, relative) is associated with outcomes of Covid infections, a population-based study in 121 countries https://t.co/dWMmyMfBSLhttps://t.co/hW7Jq1mhdo
2022-11-16 01:17:21 RT @PeterHotez: Important and well-conducted study by @EricTopol My take: even though rebound is real and significant, in my conversation…
2022-11-15 23:33:25 For the people pointing out that @POTUS, @CDCDirector and Tony Fauci all had Paxlovid rebound, that's why you do prospective, systematic studies. We've learned that "rebound" also occurs without Paxlovid and that anecdotes/twitter are not representative of the real world
2022-11-15 20:14:34 Each participant did rapid antigen testing every other day through day 15, symptom surveys through day 17, and are being followed for 6 months https://t.co/8bDtswdytR
2022-11-15 20:00:32 The event curves for Paxlovid treated compared with controls https://t.co/2ykeOuBUAX
2022-11-15 19:56:25 Our prospective Paxlovid rebound study with controls preprint is posted By symptoms: ~12% rebound (19% Pax vs 7% controls) By positive testing: ~5% rebound (14% Pax vs 9% controls) Much lower than many estimates https://t.co/czeGEYIJvA by @JayPandit @michaelmina_lab @ScrippsRTI
2022-11-15 16:11:35 Start of new waves in South Korea and Japan, having sustained recent BA.5 waves and this variant still accounts for most new casesThe pandemic isn't over https://t.co/DhwWhZ4CJi
2022-11-15 16:01:28 Here's the article. A potential path to preventing brain tissue from dying https://t.co/ODGuD8X8iy
2022-11-15 00:48:03 Today's pandemic briefing on new booster data and the thick soup of new variantshttps://t.co/LA3nl6FxSx
2022-11-14 17:22:13 RT @danrdanny: Excited to see our work on 3-hour genome sequencing highlighted here! If you think this is interesting we have a bench scien…
2022-11-14 17:04:44 The potential for detecting heart dysfunction (ejection fraction <
2022-11-14 14:37:14 RT @EricTopol: Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so m…
2022-11-14 14:28:16 In aggregate, solid evidence that the bivalent booster elicits a strong and broadened neutralizing antibody immune response. Yet, less than 27% of Americans 65+, the have had it and poor uptake across all age groupshttps://t.co/V5Xlj3cKln
2022-11-14 14:28:15https://t.co/fJbLUdcYJdCoverage @statnews by @matthewherper w/ @SutharLab, whose results were replicated by the new data (Table)
2022-11-14 12:00:01 Moderna BA.5 bivalent booster results announced (via @moderna_tx press release)—largest study to date of >
2022-11-21 01:21:26 Tumors also can have fungi within them which can, like (and interact with) bacteria, have functional impact on cancer and its therapy https://t.co/KDWV9XjQzW @CellCellPress https://t.co/72eyqbrMq0
2022-11-21 00:03:11 @steveagee Approved in China, India, Iran Big clinical trial in Mexico A company (Ocugen) has licensed the Bharat Biotech (India, IP from @WUSTL) for the United States but there’s no regulatory guidance by @US_FDA yet for Covid nasal vaccines
2022-11-20 23:46:08 RT @EricTopol: My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SAR…
2022-11-20 18:55:24 The consistent increased risk of diabetes after Covid across all age groups, highest in the first 3 months after infection, from a systematic review of 9 studies, ~40 million people https://t.co/uJ5T3ENGrjhttps://t.co/GZzZmhDrfH
2022-11-20 17:54:58 Months ago @VirusesImmunity and I laid out the strong case for nasal vaccines to achieve containment of the virus, breaking the chain of transmission at the individual and population level https://t.co/OujfFxMgU6 @SciImmunology https://t.co/lPGQTC2T1i
2022-11-20 16:23:27 I'm outraged by this pathetic and inexcusable inability for this country to go after nasal and better, durable, variant-proof vaccines https://t.co/u2AErUyYpNhttps://t.co/CuRQ51q8pi
2022-11-20 15:45:21 Why is the outlook favorable when new variants with marked immune evasion and growth advantage have become dominant? https://t.co/DqMJ7LSJZC
2022-11-19 19:46:26 My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SARSCoV2 variant with a marked increase in immune evasion not to have induced a wave. https://t.co/DqMJ7LAALu
2022-11-19 15:20:02 I thought that many bytes should be named helluva but the new name is quetta https://t.co/d77lA6LTc2
2022-11-19 00:57:34 This poses a major concern for immunocompromised who have benefited from Evusheld (preventive) &
2022-11-19 00:57:33 The BQ.1.1 variant, as compared with many of the other new variants, is resistant to all clinically used monoclonal antibodies. BQ.1/BQ.1.1 are now the dominant variants in the United States https://t.co/PCFPSGF2uy @TheLancetInfDis https://t.co/dHucxoGokC
2022-11-18 21:17:45 Good news: 1st drug to alter the course of Type 1 diabetes in 100 years approved by @US_FDA Bad news: it costs ~$200,000/14-day treatment
2022-11-18 20:40:04 @legalnomads BA.1 bivalent induces about half as much neutralizing antibodies vs BA.5 as the BA.5 bivalent (live virus assays), both better than original booster. Whether that translates to any difference clinically is unclear.
2022-11-18 20:12:01 The bivalent BA.1 booster is being use in many countries around the world, but data are limited compared with the original (WT) booster against BA.5. New today: doubling of neutralizing antibodies https://t.co/M2YUB5wpH4 (BA.5 bivalent was ~3-5X WT in several recent studies) https://t.co/xYwnfcXkm6
2022-11-18 18:44:04 How to improve science discovery and productivity? Not just about money (see graph below): funding fast, bets on talent/people, take risk, think big https://t.co/HEAXu2L87H by @greg_ip w/ @patrickc @tylercowen @pdhsu https://t.co/7O6qplOf9C
2022-11-18 18:01:46 @KMunoz46 Correct. That's why there's no good explanation
2022-11-18 17:44:15 RT @ElinSilveous: “Foreign rivals have raced ahead in approving long-awaited nasal-spray vaccines, including one invented in St. Louis, cre…
2022-11-18 17:27:39 Does going to @NFL games increase risk of Covid? https://t.co/UzghLiDCgT Interesting findings of an association in the 14-21 day postgame period when >
2022-11-18 15:54:32 A systematic review of Covid vaccines for kids age 5 to 11 (30 studies) Effectiveness 75% vs hospitalization
2022-11-18 15:45:27 @TopherSpiro46 @AshishKJha46 I know, Topher. Absolutely no reason for refusal of Congress and failure to fund. Appreciate @ashishkjha's strong advocacy
2022-11-18 14:58:07 An explainer for why the US is not pursuing nasal vaccines. TLDR: there is no good explanation https://t.co/Ih6ypzOva7 by @benjmueller w/ @VirusesImmunity @florian_krammer
2022-11-18 03:51:13 @lainemartin1 Very appreciative of your note!
2022-11-18 03:33:22 Refers to BQ.1.1 (see blue arrow)
2022-11-18 03:32:12 New data for why a bivalent booster will help: "These data suggest the bivalent BA.4/5 vaccine is more immunogenic than the original ...vaccine against circulating Omicron sublineages, including BQ.1.1 that is becoming prevalent globally." https://t.co/wAoTyur6be Get boosted! https://t.co/j21g0bELIp
2022-11-18 00:42:08 By current variant growth advantage patterns, the next couple of months in the US will be BQ.1.x dominated. Bivalent boosters will help protect
2022-11-17 23:56:45 A new report confirms the immune escape of the BQ.1.1 variant, along with BA.4.6 &
2022-11-17 23:26:54 We still don't have a way to diagnosis chronic traumatic encephalopathy (CTE) in people who are alive, but may be getting closer https://t.co/SftRQR7TWD by @el_belson @NYTSports https://t.co/BTh6oXUxRg
2022-11-17 21:47:06 RT @rowlsmanthorpe: Long covid has wrecked my life It’s bad, very bad. But you knew that already I want to tell you a hopeful story. A st…
2022-11-17 17:33:41 RT @linseymarr: You get a 2-for-1 with filtration. It removes virus from the air and PM2.5 that is associated with an increased risk of inf…
2022-11-17 17:28:45 RT @Aiims1742: Important #OpenAccess paper in @Cancer_Cell from @CharlesSwanton &
2022-11-17 17:09:54 Strong evidence that particulate matter air pollution (ambient PM2.5) increases the risk of Covid infection, a systematic analysis https://t.co/RueG44Hk2m @MonashUni https://t.co/kpREoqJVPi
2022-11-17 15:46:50 About 1 in 5 of us have an APOE4 gene variant, the #1 genetic risk factor for Alzheimer's disease. But the mechanism for brain injury was a mystery, now getting unraveled (cholesterol processing by oligodendrocytes) https://t.co/gIpGt0CA28 @nature https://t.co/hbmdpO6R3thttps://t.co/4zFZIhUTCI
2022-11-17 01:27:50 @amitsurg Because they do. That's mostly related to the excess of rebound after Paxlovid
2022-11-17 00:58:05 We've (re-)learned a few important lessons from the Paxlovid rebound experience about randomized trials and real world evidence Reviewed here https://t.co/jmT9vIipg9
2022-11-16 19:46:41 The Paxlovid rebound story New data reviewed in the 16 November daily briefing of Ground Truths https://t.co/jmT9vIipg9
2022-11-16 17:48:15 The US Covid death rate (7-day average) drops below 300 for the first time since June 2022. Lowest since pandemic began was 222 in July 2021. https://t.co/Cze8bZgtVrhttps://t.co/uxGosRY1KO
2022-11-16 17:14:12 Immunotherapy can induce myocarditis but the mechanism has been poorly understood. A new report @nature today supports the culprit auto-antigen role of α-myosin and cytotoxic T-cells directed to it https://t.co/uPRUQBbkVh by @MargaretAxelrod @BalkoLab https://t.co/vWZP1IcW19
2022-11-16 16:37:07 Humidity (indoor, relative) is associated with outcomes of Covid infections, a population-based study in 121 countries https://t.co/dWMmyMfBSLhttps://t.co/hW7Jq1mhdo
2022-11-16 01:17:21 RT @PeterHotez: Important and well-conducted study by @EricTopol My take: even though rebound is real and significant, in my conversation…
2022-11-15 23:33:25 For the people pointing out that @POTUS, @CDCDirector and Tony Fauci all had Paxlovid rebound, that's why you do prospective, systematic studies. We've learned that "rebound" also occurs without Paxlovid and that anecdotes/twitter are not representative of the real world
2022-11-15 20:14:34 Each participant did rapid antigen testing every other day through day 15, symptom surveys through day 17, and are being followed for 6 months https://t.co/8bDtswdytR
2022-11-15 20:00:32 The event curves for Paxlovid treated compared with controls https://t.co/2ykeOuBUAX
2022-11-15 19:56:25 Our prospective Paxlovid rebound study with controls preprint is posted By symptoms: ~12% rebound (19% Pax vs 7% controls) By positive testing: ~5% rebound (14% Pax vs 9% controls) Much lower than many estimates https://t.co/czeGEYIJvA by @JayPandit @michaelmina_lab @ScrippsRTI
2022-11-15 16:11:35 Start of new waves in South Korea and Japan, having sustained recent BA.5 waves and this variant still accounts for most new casesThe pandemic isn't over https://t.co/DhwWhZ4CJi
2022-11-15 16:01:28 Here's the article. A potential path to preventing brain tissue from dying https://t.co/ODGuD8X8iy
2022-11-15 00:48:03 Today's pandemic briefing on new booster data and the thick soup of new variantshttps://t.co/LA3nl6FxSx
2022-11-14 17:22:13 RT @danrdanny: Excited to see our work on 3-hour genome sequencing highlighted here! If you think this is interesting we have a bench scien…
2022-11-14 17:04:44 The potential for detecting heart dysfunction (ejection fraction <
2022-11-14 14:37:14 RT @EricTopol: Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so m…
2022-11-14 14:28:16 In aggregate, solid evidence that the bivalent booster elicits a strong and broadened neutralizing antibody immune response. Yet, less than 27% of Americans 65+, the have had it and poor uptake across all age groupshttps://t.co/V5Xlj3cKln
2022-11-14 14:28:15https://t.co/fJbLUdcYJdCoverage @statnews by @matthewherper w/ @SutharLab, whose results were replicated by the new data (Table)
2022-11-14 12:00:01 Moderna BA.5 bivalent booster results announced (via @moderna_tx press release)—largest study to date of >
2022-11-21 16:14:51 As of 10 November 2022, it is estimated that 94% of Americans have had Covid at least once, much of those infections in the past year. Ranking of states w/ most vulnerability d/t lack of vaccines/ boosters https://t.co/W5zzyrD0vN @HarvardChanSPH https://t.co/FlY9MqC3Jq
2022-11-21 14:55:09 Unlike the prior 2 holiday seasons in the US, a major surge is unlikely, which is not in keeping with new, dominant variants with marked immune evasion. https://t.co/DqMJ7LAALu However, waning of immunity, poor uptake of boosters, and lack of mitigation sets up vulnerability https://t.co/rEQSBzeewg
2022-11-21 01:21:26 Tumors also can have fungi within them which can, like (and interact with) bacteria, have functional impact on cancer and its therapy https://t.co/KDWV9XjQzW @CellCellPress https://t.co/72eyqbrMq0
2022-11-21 00:03:11 @steveagee Approved in China, India, Iran Big clinical trial in Mexico A company (Ocugen) has licensed the Bharat Biotech (India, IP from @WUSTL) for the United States but there’s no regulatory guidance by @US_FDA yet for Covid nasal vaccines
2022-11-20 23:46:08 RT @EricTopol: My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SAR…
2022-11-20 18:55:24 The consistent increased risk of diabetes after Covid across all age groups, highest in the first 3 months after infection, from a systematic review of 9 studies, ~40 million people https://t.co/uJ5T3ENGrjhttps://t.co/GZzZmhDrfH
2022-11-20 17:54:58 Months ago @VirusesImmunity and I laid out the strong case for nasal vaccines to achieve containment of the virus, breaking the chain of transmission at the individual and population level https://t.co/OujfFxMgU6 @SciImmunology https://t.co/lPGQTC2T1i
2022-11-20 16:23:27 I'm outraged by this pathetic and inexcusable inability for this country to go after nasal and better, durable, variant-proof vaccines https://t.co/u2AErUyYpNhttps://t.co/CuRQ51q8pi
2022-11-20 15:45:21 Why is the outlook favorable when new variants with marked immune evasion and growth advantage have become dominant? https://t.co/DqMJ7LSJZC
2022-11-19 19:46:26 My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SARSCoV2 variant with a marked increase in immune evasion not to have induced a wave. https://t.co/DqMJ7LAALu
2022-11-19 15:20:02 I thought that many bytes should be named helluva but the new name is quetta https://t.co/d77lA6LTc2
2022-11-19 00:57:34 This poses a major concern for immunocompromised who have benefited from Evusheld (preventive) &
2022-11-19 00:57:33 The BQ.1.1 variant, as compared with many of the other new variants, is resistant to all clinically used monoclonal antibodies. BQ.1/BQ.1.1 are now the dominant variants in the United States https://t.co/PCFPSGF2uy @TheLancetInfDis https://t.co/dHucxoGokC
2022-11-18 21:17:45 Good news: 1st drug to alter the course of Type 1 diabetes in 100 years approved by @US_FDA Bad news: it costs ~$200,000/14-day treatment
2022-11-18 20:40:04 @legalnomads BA.1 bivalent induces about half as much neutralizing antibodies vs BA.5 as the BA.5 bivalent (live virus assays), both better than original booster. Whether that translates to any difference clinically is unclear.
2022-11-18 20:12:01 The bivalent BA.1 booster is being use in many countries around the world, but data are limited compared with the original (WT) booster against BA.5. New today: doubling of neutralizing antibodies https://t.co/M2YUB5wpH4 (BA.5 bivalent was ~3-5X WT in several recent studies) https://t.co/xYwnfcXkm6
2022-11-18 18:44:04 How to improve science discovery and productivity? Not just about money (see graph below): funding fast, bets on talent/people, take risk, think big https://t.co/HEAXu2L87H by @greg_ip w/ @patrickc @tylercowen @pdhsu https://t.co/7O6qplOf9C
2022-11-18 18:01:46 @KMunoz46 Correct. That's why there's no good explanation
2022-11-18 17:44:15 RT @ElinSilveous: “Foreign rivals have raced ahead in approving long-awaited nasal-spray vaccines, including one invented in St. Louis, cre…
2022-11-18 17:27:39 Does going to @NFL games increase risk of Covid? https://t.co/UzghLiDCgT Interesting findings of an association in the 14-21 day postgame period when >
2022-11-18 15:54:32 A systematic review of Covid vaccines for kids age 5 to 11 (30 studies) Effectiveness 75% vs hospitalization
2022-11-18 15:45:27 @TopherSpiro46 @AshishKJha46 I know, Topher. Absolutely no reason for refusal of Congress and failure to fund. Appreciate @ashishkjha's strong advocacy
2022-11-18 14:58:07 An explainer for why the US is not pursuing nasal vaccines. TLDR: there is no good explanation https://t.co/Ih6ypzOva7 by @benjmueller w/ @VirusesImmunity @florian_krammer
2022-11-18 03:51:13 @lainemartin1 Very appreciative of your note!
2022-11-18 03:33:22 Refers to BQ.1.1 (see blue arrow)
2022-11-18 03:32:12 New data for why a bivalent booster will help: "These data suggest the bivalent BA.4/5 vaccine is more immunogenic than the original ...vaccine against circulating Omicron sublineages, including BQ.1.1 that is becoming prevalent globally." https://t.co/wAoTyur6be Get boosted! https://t.co/j21g0bELIp
2022-11-18 00:42:08 By current variant growth advantage patterns, the next couple of months in the US will be BQ.1.x dominated. Bivalent boosters will help protect
2022-11-17 23:56:45 A new report confirms the immune escape of the BQ.1.1 variant, along with BA.4.6 &
2022-11-17 23:26:54 We still don't have a way to diagnosis chronic traumatic encephalopathy (CTE) in people who are alive, but may be getting closer https://t.co/SftRQR7TWD by @el_belson @NYTSports https://t.co/BTh6oXUxRg
2022-11-17 21:47:06 RT @rowlsmanthorpe: Long covid has wrecked my life It’s bad, very bad. But you knew that already I want to tell you a hopeful story. A st…
2022-11-17 17:33:41 RT @linseymarr: You get a 2-for-1 with filtration. It removes virus from the air and PM2.5 that is associated with an increased risk of inf…
2022-11-17 17:28:45 RT @Aiims1742: Important #OpenAccess paper in @Cancer_Cell from @CharlesSwanton &
2022-11-17 17:09:54 Strong evidence that particulate matter air pollution (ambient PM2.5) increases the risk of Covid infection, a systematic analysis https://t.co/RueG44Hk2m @MonashUni https://t.co/kpREoqJVPi
2022-11-17 15:46:50 About 1 in 5 of us have an APOE4 gene variant, the #1 genetic risk factor for Alzheimer's disease. But the mechanism for brain injury was a mystery, now getting unraveled (cholesterol processing by oligodendrocytes) https://t.co/gIpGt0CA28 @nature https://t.co/hbmdpO6R3thttps://t.co/4zFZIhUTCI
2022-11-17 01:27:50 @amitsurg Because they do. That's mostly related to the excess of rebound after Paxlovid
2022-11-17 00:58:05 We've (re-)learned a few important lessons from the Paxlovid rebound experience about randomized trials and real world evidence Reviewed here https://t.co/jmT9vIipg9
2022-11-16 19:46:41 The Paxlovid rebound story New data reviewed in the 16 November daily briefing of Ground Truths https://t.co/jmT9vIipg9
2022-11-16 17:48:15 The US Covid death rate (7-day average) drops below 300 for the first time since June 2022. Lowest since pandemic began was 222 in July 2021. https://t.co/Cze8bZgtVrhttps://t.co/uxGosRY1KO
2022-11-16 17:14:12 Immunotherapy can induce myocarditis but the mechanism has been poorly understood. A new report @nature today supports the culprit auto-antigen role of α-myosin and cytotoxic T-cells directed to it https://t.co/uPRUQBbkVh by @MargaretAxelrod @BalkoLab https://t.co/vWZP1IcW19
2022-11-16 16:37:07 Humidity (indoor, relative) is associated with outcomes of Covid infections, a population-based study in 121 countries https://t.co/dWMmyMfBSLhttps://t.co/hW7Jq1mhdo
2022-11-16 01:17:21 RT @PeterHotez: Important and well-conducted study by @EricTopol My take: even though rebound is real and significant, in my conversation…
2022-11-15 23:33:25 For the people pointing out that @POTUS, @CDCDirector and Tony Fauci all had Paxlovid rebound, that's why you do prospective, systematic studies. We've learned that "rebound" also occurs without Paxlovid and that anecdotes/twitter are not representative of the real world
2022-11-15 20:14:34 Each participant did rapid antigen testing every other day through day 15, symptom surveys through day 17, and are being followed for 6 months https://t.co/8bDtswdytR
2022-11-15 20:00:32 The event curves for Paxlovid treated compared with controls https://t.co/2ykeOuBUAX
2022-11-15 19:56:25 Our prospective Paxlovid rebound study with controls preprint is posted By symptoms: ~12% rebound (19% Pax vs 7% controls) By positive testing: ~5% rebound (14% Pax vs 9% controls) Much lower than many estimates https://t.co/czeGEYIJvA by @JayPandit @michaelmina_lab @ScrippsRTI
2022-11-15 16:11:35 Start of new waves in South Korea and Japan, having sustained recent BA.5 waves and this variant still accounts for most new casesThe pandemic isn't over https://t.co/DhwWhZ4CJi
2022-11-15 16:01:28 Here's the article. A potential path to preventing brain tissue from dying https://t.co/ODGuD8X8iy
2022-11-15 00:48:03 Today's pandemic briefing on new booster data and the thick soup of new variantshttps://t.co/LA3nl6FxSx
2022-11-14 17:22:13 RT @danrdanny: Excited to see our work on 3-hour genome sequencing highlighted here! If you think this is interesting we have a bench scien…
2022-11-14 17:04:44 The potential for detecting heart dysfunction (ejection fraction <
2022-11-14 14:37:14 RT @EricTopol: Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so m…
2022-11-14 14:28:16 In aggregate, solid evidence that the bivalent booster elicits a strong and broadened neutralizing antibody immune response. Yet, less than 27% of Americans 65+, the have had it and poor uptake across all age groupshttps://t.co/V5Xlj3cKln
2022-11-14 14:28:15https://t.co/fJbLUdcYJdCoverage @statnews by @matthewherper w/ @SutharLab, whose results were replicated by the new data (Table)
2022-11-14 12:00:01 Moderna BA.5 bivalent booster results announced (via @moderna_tx press release)—largest study to date of >
2022-11-22 20:53:31 Vaccine effectiveness vs reinfection, a Denmark nationwide study The reduction of reinfection after primary vaccination was significant for the Alpha, Delta, and Omicron variant periods, ranging from 60-94%, lasting up to 9 months https://t.co/C9gWMfC1Tc @PLOSMedicine https://t.co/5VZq1Hgwk2
2022-11-22 20:46:42 Illuminating new @CDCMMWR repot for real world Paxlovid reduction of hospitalization by ~50% across all subgroups by age, vaccinated status, prior infection, month of infection (proxy for variant) https://t.co/LoMLSPepmdhttps://t.co/oLNscrf5M4
2022-11-22 16:19:46 “Americans have been trained for 100 years to think that the hospital is the best place to be, the safest place. But we have strong evidence that the outcomes are actually better at home.” The hospital-at-home movement is just getting started https://t.co/TnfDzSCeoK @paula_span https://t.co/tvxqFMqwE5
2022-11-21 16:14:51 As of 10 November 2022, it is estimated that 94% of Americans have had Covid at least once, much of those infections in the past year. Ranking of states w/ most vulnerability d/t lack of vaccines/ boosters https://t.co/W5zzyrD0vN @HarvardChanSPH https://t.co/FlY9MqC3Jq
2022-11-21 14:55:09 Unlike the prior 2 holiday seasons in the US, a major surge is unlikely, which is not in keeping with new, dominant variants with marked immune evasion. https://t.co/DqMJ7LAALu However, waning of immunity, poor uptake of boosters, and lack of mitigation sets up vulnerability https://t.co/rEQSBzeewg
2022-11-21 01:21:26 Tumors also can have fungi within them which can, like (and interact with) bacteria, have functional impact on cancer and its therapy https://t.co/KDWV9XjQzW @CellCellPress https://t.co/72eyqbrMq0
2022-11-21 00:03:11 @steveagee Approved in China, India, Iran Big clinical trial in Mexico A company (Ocugen) has licensed the Bharat Biotech (India, IP from @WUSTL) for the United States but there’s no regulatory guidance by @US_FDA yet for Covid nasal vaccines
2022-11-20 23:46:08 RT @EricTopol: My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SAR…
2022-11-20 18:55:24 The consistent increased risk of diabetes after Covid across all age groups, highest in the first 3 months after infection, from a systematic review of 9 studies, ~40 million people https://t.co/uJ5T3ENGrjhttps://t.co/GZzZmhDrfH
2022-11-20 17:54:58 Months ago @VirusesImmunity and I laid out the strong case for nasal vaccines to achieve containment of the virus, breaking the chain of transmission at the individual and population level https://t.co/OujfFxMgU6 @SciImmunology https://t.co/lPGQTC2T1i
2022-11-20 16:23:27 I'm outraged by this pathetic and inexcusable inability for this country to go after nasal and better, durable, variant-proof vaccines https://t.co/u2AErUyYpNhttps://t.co/CuRQ51q8pi
2022-11-20 15:45:21 Why is the outlook favorable when new variants with marked immune evasion and growth advantage have become dominant? https://t.co/DqMJ7LSJZC
2022-11-19 19:46:26 My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SARSCoV2 variant with a marked increase in immune evasion not to have induced a wave. https://t.co/DqMJ7LAALu
2022-11-19 15:20:02 I thought that many bytes should be named helluva but the new name is quetta https://t.co/d77lA6LTc2
2022-11-19 00:57:34 This poses a major concern for immunocompromised who have benefited from Evusheld (preventive) &
2022-11-19 00:57:33 The BQ.1.1 variant, as compared with many of the other new variants, is resistant to all clinically used monoclonal antibodies. BQ.1/BQ.1.1 are now the dominant variants in the United States https://t.co/PCFPSGF2uy @TheLancetInfDis https://t.co/dHucxoGokC
2022-11-18 21:17:45 Good news: 1st drug to alter the course of Type 1 diabetes in 100 years approved by @US_FDA Bad news: it costs ~$200,000/14-day treatment
2022-11-18 20:40:04 @legalnomads BA.1 bivalent induces about half as much neutralizing antibodies vs BA.5 as the BA.5 bivalent (live virus assays), both better than original booster. Whether that translates to any difference clinically is unclear.
2022-11-18 20:12:01 The bivalent BA.1 booster is being use in many countries around the world, but data are limited compared with the original (WT) booster against BA.5. New today: doubling of neutralizing antibodies https://t.co/M2YUB5wpH4 (BA.5 bivalent was ~3-5X WT in several recent studies) https://t.co/xYwnfcXkm6
2022-11-18 18:44:04 How to improve science discovery and productivity? Not just about money (see graph below): funding fast, bets on talent/people, take risk, think big https://t.co/HEAXu2L87H by @greg_ip w/ @patrickc @tylercowen @pdhsu https://t.co/7O6qplOf9C
2022-11-18 18:01:46 @KMunoz46 Correct. That's why there's no good explanation
2022-11-18 17:44:15 RT @ElinSilveous: “Foreign rivals have raced ahead in approving long-awaited nasal-spray vaccines, including one invented in St. Louis, cre…
2022-11-18 17:27:39 Does going to @NFL games increase risk of Covid? https://t.co/UzghLiDCgT Interesting findings of an association in the 14-21 day postgame period when >
2022-11-18 15:54:32 A systematic review of Covid vaccines for kids age 5 to 11 (30 studies) Effectiveness 75% vs hospitalization
2022-11-18 15:45:27 @TopherSpiro46 @AshishKJha46 I know, Topher. Absolutely no reason for refusal of Congress and failure to fund. Appreciate @ashishkjha's strong advocacy
2022-11-18 14:58:07 An explainer for why the US is not pursuing nasal vaccines. TLDR: there is no good explanation https://t.co/Ih6ypzOva7 by @benjmueller w/ @VirusesImmunity @florian_krammer
2022-11-18 03:51:13 @lainemartin1 Very appreciative of your note!
2022-11-18 03:33:22 Refers to BQ.1.1 (see blue arrow)
2022-11-18 03:32:12 New data for why a bivalent booster will help: "These data suggest the bivalent BA.4/5 vaccine is more immunogenic than the original ...vaccine against circulating Omicron sublineages, including BQ.1.1 that is becoming prevalent globally." https://t.co/wAoTyur6be Get boosted! https://t.co/j21g0bELIp
2022-11-18 00:42:08 By current variant growth advantage patterns, the next couple of months in the US will be BQ.1.x dominated. Bivalent boosters will help protect
2022-11-17 23:56:45 A new report confirms the immune escape of the BQ.1.1 variant, along with BA.4.6 &
2022-11-17 23:26:54 We still don't have a way to diagnosis chronic traumatic encephalopathy (CTE) in people who are alive, but may be getting closer https://t.co/SftRQR7TWD by @el_belson @NYTSports https://t.co/BTh6oXUxRg
2022-11-17 21:47:06 RT @rowlsmanthorpe: Long covid has wrecked my life It’s bad, very bad. But you knew that already I want to tell you a hopeful story. A st…
2022-11-17 17:33:41 RT @linseymarr: You get a 2-for-1 with filtration. It removes virus from the air and PM2.5 that is associated with an increased risk of inf…
2022-11-17 17:28:45 RT @Aiims1742: Important #OpenAccess paper in @Cancer_Cell from @CharlesSwanton &
2022-11-17 17:09:54 Strong evidence that particulate matter air pollution (ambient PM2.5) increases the risk of Covid infection, a systematic analysis https://t.co/RueG44Hk2m @MonashUni https://t.co/kpREoqJVPi
2022-11-17 15:46:50 About 1 in 5 of us have an APOE4 gene variant, the #1 genetic risk factor for Alzheimer's disease. But the mechanism for brain injury was a mystery, now getting unraveled (cholesterol processing by oligodendrocytes) https://t.co/gIpGt0CA28 @nature https://t.co/hbmdpO6R3thttps://t.co/4zFZIhUTCI
2022-11-17 01:27:50 @amitsurg Because they do. That's mostly related to the excess of rebound after Paxlovid
2022-11-17 00:58:05 We've (re-)learned a few important lessons from the Paxlovid rebound experience about randomized trials and real world evidence Reviewed here https://t.co/jmT9vIipg9
2022-11-16 19:46:41 The Paxlovid rebound story New data reviewed in the 16 November daily briefing of Ground Truths https://t.co/jmT9vIipg9
2022-11-16 17:48:15 The US Covid death rate (7-day average) drops below 300 for the first time since June 2022. Lowest since pandemic began was 222 in July 2021. https://t.co/Cze8bZgtVrhttps://t.co/uxGosRY1KO
2022-11-16 17:14:12 Immunotherapy can induce myocarditis but the mechanism has been poorly understood. A new report @nature today supports the culprit auto-antigen role of α-myosin and cytotoxic T-cells directed to it https://t.co/uPRUQBbkVh by @MargaretAxelrod @BalkoLab https://t.co/vWZP1IcW19
2022-11-16 16:37:07 Humidity (indoor, relative) is associated with outcomes of Covid infections, a population-based study in 121 countries https://t.co/dWMmyMfBSLhttps://t.co/hW7Jq1mhdo
2022-11-16 01:17:21 RT @PeterHotez: Important and well-conducted study by @EricTopol My take: even though rebound is real and significant, in my conversation…
2022-11-15 23:33:25 For the people pointing out that @POTUS, @CDCDirector and Tony Fauci all had Paxlovid rebound, that's why you do prospective, systematic studies. We've learned that "rebound" also occurs without Paxlovid and that anecdotes/twitter are not representative of the real world
2022-11-15 20:14:34 Each participant did rapid antigen testing every other day through day 15, symptom surveys through day 17, and are being followed for 6 months https://t.co/8bDtswdytR
2022-11-15 20:00:32 The event curves for Paxlovid treated compared with controls https://t.co/2ykeOuBUAX
2022-11-15 19:56:25 Our prospective Paxlovid rebound study with controls preprint is posted By symptoms: ~12% rebound (19% Pax vs 7% controls) By positive testing: ~5% rebound (14% Pax vs 9% controls) Much lower than many estimates https://t.co/czeGEYIJvA by @JayPandit @michaelmina_lab @ScrippsRTI
2022-11-15 16:11:35 Start of new waves in South Korea and Japan, having sustained recent BA.5 waves and this variant still accounts for most new casesThe pandemic isn't over https://t.co/DhwWhZ4CJi
2022-11-15 16:01:28 Here's the article. A potential path to preventing brain tissue from dying https://t.co/ODGuD8X8iy
2022-11-15 00:48:03 Today's pandemic briefing on new booster data and the thick soup of new variantshttps://t.co/LA3nl6FxSx
2022-11-14 17:22:13 RT @danrdanny: Excited to see our work on 3-hour genome sequencing highlighted here! If you think this is interesting we have a bench scien…
2022-11-14 17:04:44 The potential for detecting heart dysfunction (ejection fraction <
2022-11-14 14:37:14 RT @EricTopol: Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so m…
2022-11-14 14:28:16 In aggregate, solid evidence that the bivalent booster elicits a strong and broadened neutralizing antibody immune response. Yet, less than 27% of Americans 65+, the have had it and poor uptake across all age groupshttps://t.co/V5Xlj3cKln
2022-11-14 14:28:15https://t.co/fJbLUdcYJdCoverage @statnews by @matthewherper w/ @SutharLab, whose results were replicated by the new data (Table)
2022-11-14 12:00:01 Moderna BA.5 bivalent booster results announced (via @moderna_tx press release)—largest study to date of >
2022-11-24 19:58:48 The growing body of evidence that the 3 respiratory viruses (Covid, flu, RSV) interfere with each other’s spread, limiting a tripledemic's threat https://t.co/auPadYfbsa @ScienceMagazine by @sciencecohen https://t.co/yUKqrZyNUW
2022-11-24 19:25:13 We're heading to a universal toolkit to engineer cells for diverse applications: cancer, autoimmune conditions, neurodegenerative diseases, repair of injured tissue and organs https://t.co/a1h3N2QCQY This week's @ScienceMagazine special section https://t.co/lPuSGVmA5F
2022-11-24 02:17:36 There is an impersonator of me, a fake account @EricTopol5, that has been reported @twitter @TwitterSupport
2022-11-24 00:21:29 The stigma and discrimination faced by most people with #LongCovid https://t.co/s4EYkgCv10 @PLOSONE by @PantelichMarija @Dr2NisreenAlwan and colleagues https://t.co/F8MdNUYAGd
2022-11-24 00:11:41 "Our results suggest that the development of a mucosal booster vaccine dose should be further exploited to induce a stronger sIgA response." @NEJM https://t.co/OPEaVtZmQT More rationale a nasal vaccine booster and benefit of mucosal immunity to augment salivary IgA https://t.co/JTX8sDrLyV
2022-11-23 23:35:06 This is about the short term outlook only, as I reviewed here https://t.co/DqMJ7LAALu still needed
2022-11-23 22:43:13 A very informative, fun and engaging conversation with @trishgreenhalgh about what constitutes evidence in medicine and the pandemic https://t.co/IaVXavjlC7 W/ @cuttingforstone @Medscape
2022-11-23 17:53:31 On the 1-year anniversary of Omicron’s detection, things are looking up. Worse variants countered by tens of millions of infections, vaccines, and boosters make a difference https://t.co/AsFyGcpFK9
2022-11-23 16:33:10 Japan's 2nd BA.5 wave reaches case peak level of Omicron BA.1 (>
2022-11-22 20:53:31 Vaccine effectiveness vs reinfection, a Denmark nationwide study The reduction of reinfection after primary vaccination was significant for the Alpha, Delta, and Omicron variant periods, ranging from 60-94%, lasting up to 9 months https://t.co/C9gWMfC1Tc @PLOSMedicine https://t.co/5VZq1Hgwk2
2022-11-22 20:46:42 Illuminating new @CDCMMWR repot for real world Paxlovid reduction of hospitalization by ~50% across all subgroups by age, vaccinated status, prior infection, month of infection (proxy for variant) https://t.co/LoMLSPepmdhttps://t.co/oLNscrf5M4
2022-11-22 16:19:46 “Americans have been trained for 100 years to think that the hospital is the best place to be, the safest place. But we have strong evidence that the outcomes are actually better at home.” The hospital-at-home movement is just getting started https://t.co/TnfDzSCeoK @paula_span https://t.co/tvxqFMqwE5
2022-11-21 16:14:51 As of 10 November 2022, it is estimated that 94% of Americans have had Covid at least once, much of those infections in the past year. Ranking of states w/ most vulnerability d/t lack of vaccines/ boosters https://t.co/W5zzyrD0vN @HarvardChanSPH https://t.co/FlY9MqC3Jq
2022-11-21 14:55:09 Unlike the prior 2 holiday seasons in the US, a major surge is unlikely, which is not in keeping with new, dominant variants with marked immune evasion. https://t.co/DqMJ7LAALu However, waning of immunity, poor uptake of boosters, and lack of mitigation sets up vulnerability https://t.co/rEQSBzeewg
2022-11-21 01:21:26 Tumors also can have fungi within them which can, like (and interact with) bacteria, have functional impact on cancer and its therapy https://t.co/KDWV9XjQzW @CellCellPress https://t.co/72eyqbrMq0
2022-11-21 00:03:11 @steveagee Approved in China, India, Iran Big clinical trial in Mexico A company (Ocugen) has licensed the Bharat Biotech (India, IP from @WUSTL) for the United States but there’s no regulatory guidance by @US_FDA yet for Covid nasal vaccines
2022-11-20 23:46:08 RT @EricTopol: My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SAR…
2022-11-20 18:55:24 The consistent increased risk of diabetes after Covid across all age groups, highest in the first 3 months after infection, from a systematic review of 9 studies, ~40 million people https://t.co/uJ5T3ENGrjhttps://t.co/GZzZmhDrfH
2022-11-20 17:54:58 Months ago @VirusesImmunity and I laid out the strong case for nasal vaccines to achieve containment of the virus, breaking the chain of transmission at the individual and population level https://t.co/OujfFxMgU6 @SciImmunology https://t.co/lPGQTC2T1i
2022-11-20 16:23:27 I'm outraged by this pathetic and inexcusable inability for this country to go after nasal and better, durable, variant-proof vaccines https://t.co/u2AErUyYpNhttps://t.co/CuRQ51q8pi
2022-11-20 15:45:21 Why is the outlook favorable when new variants with marked immune evasion and growth advantage have become dominant? https://t.co/DqMJ7LSJZC
2022-11-19 19:46:26 My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SARSCoV2 variant with a marked increase in immune evasion not to have induced a wave. https://t.co/DqMJ7LAALu
2022-11-19 15:20:02 I thought that many bytes should be named helluva but the new name is quetta https://t.co/d77lA6LTc2
2022-11-19 00:57:34 This poses a major concern for immunocompromised who have benefited from Evusheld (preventive) &
2022-11-19 00:57:33 The BQ.1.1 variant, as compared with many of the other new variants, is resistant to all clinically used monoclonal antibodies. BQ.1/BQ.1.1 are now the dominant variants in the United States https://t.co/PCFPSGF2uy @TheLancetInfDis https://t.co/dHucxoGokC
2022-11-18 21:17:45 Good news: 1st drug to alter the course of Type 1 diabetes in 100 years approved by @US_FDA Bad news: it costs ~$200,000/14-day treatment
2022-11-18 20:40:04 @legalnomads BA.1 bivalent induces about half as much neutralizing antibodies vs BA.5 as the BA.5 bivalent (live virus assays), both better than original booster. Whether that translates to any difference clinically is unclear.
2022-11-18 20:12:01 The bivalent BA.1 booster is being use in many countries around the world, but data are limited compared with the original (WT) booster against BA.5. New today: doubling of neutralizing antibodies https://t.co/M2YUB5wpH4 (BA.5 bivalent was ~3-5X WT in several recent studies) https://t.co/xYwnfcXkm6
2022-11-18 18:44:04 How to improve science discovery and productivity? Not just about money (see graph below): funding fast, bets on talent/people, take risk, think big https://t.co/HEAXu2L87H by @greg_ip w/ @patrickc @tylercowen @pdhsu https://t.co/7O6qplOf9C
2022-11-18 18:01:46 @KMunoz46 Correct. That's why there's no good explanation
2022-11-18 17:44:15 RT @ElinSilveous: “Foreign rivals have raced ahead in approving long-awaited nasal-spray vaccines, including one invented in St. Louis, cre…
2022-11-18 17:27:39 Does going to @NFL games increase risk of Covid? https://t.co/UzghLiDCgT Interesting findings of an association in the 14-21 day postgame period when >
2022-11-18 15:54:32 A systematic review of Covid vaccines for kids age 5 to 11 (30 studies) Effectiveness 75% vs hospitalization
2022-11-18 15:45:27 @TopherSpiro46 @AshishKJha46 I know, Topher. Absolutely no reason for refusal of Congress and failure to fund. Appreciate @ashishkjha's strong advocacy
2022-11-18 14:58:07 An explainer for why the US is not pursuing nasal vaccines. TLDR: there is no good explanation https://t.co/Ih6ypzOva7 by @benjmueller w/ @VirusesImmunity @florian_krammer
2022-11-18 03:51:13 @lainemartin1 Very appreciative of your note!
2022-11-18 03:33:22 Refers to BQ.1.1 (see blue arrow)
2022-11-18 03:32:12 New data for why a bivalent booster will help: "These data suggest the bivalent BA.4/5 vaccine is more immunogenic than the original ...vaccine against circulating Omicron sublineages, including BQ.1.1 that is becoming prevalent globally." https://t.co/wAoTyur6be Get boosted! https://t.co/j21g0bELIp
2022-11-18 00:42:08 By current variant growth advantage patterns, the next couple of months in the US will be BQ.1.x dominated. Bivalent boosters will help protect
2022-11-17 23:56:45 A new report confirms the immune escape of the BQ.1.1 variant, along with BA.4.6 &
2022-11-17 23:26:54 We still don't have a way to diagnosis chronic traumatic encephalopathy (CTE) in people who are alive, but may be getting closer https://t.co/SftRQR7TWD by @el_belson @NYTSports https://t.co/BTh6oXUxRg
2022-11-17 21:47:06 RT @rowlsmanthorpe: Long covid has wrecked my life It’s bad, very bad. But you knew that already I want to tell you a hopeful story. A st…
2022-11-17 17:33:41 RT @linseymarr: You get a 2-for-1 with filtration. It removes virus from the air and PM2.5 that is associated with an increased risk of inf…
2022-11-17 17:28:45 RT @Aiims1742: Important #OpenAccess paper in @Cancer_Cell from @CharlesSwanton &
2022-11-17 17:09:54 Strong evidence that particulate matter air pollution (ambient PM2.5) increases the risk of Covid infection, a systematic analysis https://t.co/RueG44Hk2m @MonashUni https://t.co/kpREoqJVPi
2022-11-17 15:46:50 About 1 in 5 of us have an APOE4 gene variant, the #1 genetic risk factor for Alzheimer's disease. But the mechanism for brain injury was a mystery, now getting unraveled (cholesterol processing by oligodendrocytes) https://t.co/gIpGt0CA28 @nature https://t.co/hbmdpO6R3thttps://t.co/4zFZIhUTCI
2022-11-17 01:27:50 @amitsurg Because they do. That's mostly related to the excess of rebound after Paxlovid
2022-11-17 00:58:05 We've (re-)learned a few important lessons from the Paxlovid rebound experience about randomized trials and real world evidence Reviewed here https://t.co/jmT9vIipg9
2022-11-16 19:46:41 The Paxlovid rebound story New data reviewed in the 16 November daily briefing of Ground Truths https://t.co/jmT9vIipg9
2022-11-16 17:48:15 The US Covid death rate (7-day average) drops below 300 for the first time since June 2022. Lowest since pandemic began was 222 in July 2021. https://t.co/Cze8bZgtVrhttps://t.co/uxGosRY1KO
2022-11-16 17:14:12 Immunotherapy can induce myocarditis but the mechanism has been poorly understood. A new report @nature today supports the culprit auto-antigen role of α-myosin and cytotoxic T-cells directed to it https://t.co/uPRUQBbkVh by @MargaretAxelrod @BalkoLab https://t.co/vWZP1IcW19
2022-11-16 16:37:07 Humidity (indoor, relative) is associated with outcomes of Covid infections, a population-based study in 121 countries https://t.co/dWMmyMfBSLhttps://t.co/hW7Jq1mhdo
2022-11-16 01:17:21 RT @PeterHotez: Important and well-conducted study by @EricTopol My take: even though rebound is real and significant, in my conversation…
2022-11-15 23:33:25 For the people pointing out that @POTUS, @CDCDirector and Tony Fauci all had Paxlovid rebound, that's why you do prospective, systematic studies. We've learned that "rebound" also occurs without Paxlovid and that anecdotes/twitter are not representative of the real world
2022-11-15 20:14:34 Each participant did rapid antigen testing every other day through day 15, symptom surveys through day 17, and are being followed for 6 months https://t.co/8bDtswdytR
2022-11-15 20:00:32 The event curves for Paxlovid treated compared with controls https://t.co/2ykeOuBUAX
2022-11-15 19:56:25 Our prospective Paxlovid rebound study with controls preprint is posted By symptoms: ~12% rebound (19% Pax vs 7% controls) By positive testing: ~5% rebound (14% Pax vs 9% controls) Much lower than many estimates https://t.co/czeGEYIJvA by @JayPandit @michaelmina_lab @ScrippsRTI
2022-11-15 16:11:35 Start of new waves in South Korea and Japan, having sustained recent BA.5 waves and this variant still accounts for most new casesThe pandemic isn't over https://t.co/DhwWhZ4CJi
2022-11-15 16:01:28 Here's the article. A potential path to preventing brain tissue from dying https://t.co/ODGuD8X8iy
2022-11-15 00:48:03 Today's pandemic briefing on new booster data and the thick soup of new variantshttps://t.co/LA3nl6FxSx
2022-11-14 17:22:13 RT @danrdanny: Excited to see our work on 3-hour genome sequencing highlighted here! If you think this is interesting we have a bench scien…
2022-11-14 17:04:44 The potential for detecting heart dysfunction (ejection fraction <
2022-11-14 14:37:14 RT @EricTopol: Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so m…
2022-11-14 14:28:16 In aggregate, solid evidence that the bivalent booster elicits a strong and broadened neutralizing antibody immune response. Yet, less than 27% of Americans 65+, the have had it and poor uptake across all age groupshttps://t.co/V5Xlj3cKln
2022-11-14 14:28:15https://t.co/fJbLUdcYJdCoverage @statnews by @matthewherper w/ @SutharLab, whose results were replicated by the new data (Table)
2022-11-14 12:00:01 Moderna BA.5 bivalent booster results announced (via @moderna_tx press release)—largest study to date of >
2022-11-29 01:23:20 RT @CorneliusRoemer: I'm seeing quite a bit of discussion about the potential impact of a big wave in mainland China on variant evolution.…
2022-11-29 00:43:08 Good thing it's so simple to predict optimal vaccine response
2022-11-28 22:36:33 In the 2nd year of the US pandemic "the shift in COVID-19 mortality to relatively younger people.. .contributed to markedly elevated years of life lost (YLL) from this increasingly preventable cause of death" https://t.co/Vj0DleONDZ @AnnalsofIM @MarkCzeisler https://t.co/nX7ZrnF9tG
2022-11-28 22:12:32 A randomized trial of medical masks vs N95s in health care workers to prevent Covid https://t.co/CSJkFLE15z —It's woefully underpowered but ruled out a doubling of hazard for use of medical masks —In 3 of the 4 countries there was less risk with N95s (p=NS) https://t.co/B7iBvT1J9B
2022-11-28 21:20:35 Despite David Ho and colleagues new preprint, I wrote that the concerns over these variants have yet to be clinically manifest. It's the 1st time in the pandemic that lab assays of marked increases in immune evasion have not played out w/ new major surges https://t.co/DqMJ7LSJZC
2022-11-28 20:51:49 "The extent of the antigenic drift or shift measured herein is comparable to the antigenic leap made by the initial Omicron variant from its predecessors one year ago." https://t.co/2wDWjZkTr7
2022-11-28 20:51:47 Nonetheless "Our findings indicate that BQ &
2022-11-28 20:42:33 A note of alarm from Ho lab about the immune escape features of XBB &
2022-11-28 19:25:44 Very concerning about the new drug w/modest effects for Alzheimer's disease (AD) "If the patient hadn’t been on lecanemab she would be alive today.” Underlying cerebral amyloid angiopathy is present in nearly half of AD patients https://t.co/UNRoKcICNw @cpiller @ScienceMagazine
2022-11-28 16:51:27 The pandemic isn't over. Besides the major trouble that is brewing in China, it's notable that Japan's new wave has exceeded its Omicron BA.1 surge, averaging over 100,000 cases/day, and still is on steep ascent @OurWorldInData https://t.co/XnNveiLs33
2022-11-28 16:43:14 It doesn't help that the @CDCgov still defines "fully vaccinated" as 2 shots, when it would now have taken 5 shots to counter the waning immunity/protect vs severe Covid for people age 50+
2022-11-28 15:00:27 In the last month, nearly 90% of the deaths from Covid were in people age 65+ (16% of the US population). Their bivalent booster rate is less than 25%. Paxlovid use is low in seniors. A high % of these deaths are preventable. https://t.co/X3DTJcrU4F @arianaeunjung @dtkeating https://t.co/PBWUvsn3W4
2022-11-27 22:12:09 These projections for China were based on modeling. But with the low rate of seniors with booster shots, lower efficacy of their vaccines vs Omicron subvariants, and now inability to contain the virus, major trouble lies ahead https://t.co/2Ddz6coeNU
2022-11-27 03:40:59 If we can do a universal influenza vaccine, a pan-β-coronavirus (variant-proof) virus is well within reach!
2022-11-26 19:35:11 Not a good look for Covid in Arizona —Most increase in US hospitalizations in the past 2 weeks, notable in age 70+ —Hard to attribute to BQ.1.1 or other new variants https://t.co/Cze8bZxwXrhttps://t.co/xGxvgnpKiM
2022-11-26 17:01:55 The BQ.1.1 variant is resistant to all available monoclonal antibodies, including Evusheld and Bebtelovimab, leaving immunocompromised individuals particularly vulnerable. There are a few new antibodies currently being tested, with some promise https://t.co/Atfwxm2hjV @majohnso https://t.co/sjthau0XGT
2022-11-26 02:42:30 RT @DrTomasAragon: Here is are two papers from @trishgreenhalgh that complements this great podcast with @EricTopol - https://t.co/q9bk5jV…
2022-11-26 02:41:55 @dokhollidays Thank you!
2022-11-26 01:44:24 Evolution of the Omicron family of variants https://t.co/UnFls9aXeq by @CorneliusRoemer @LongDesertTrain @PeacockFlu and colleagues "It is entirely possible all the lineages described here would be outcompeted in the event of a second ‘Omicron-like event’" https://t.co/W0C7lTKx40
2022-11-25 21:18:05 RT @DrSethPT: “Whilst RCTs are a fantastic idea for testing drugs, they are a catastrophically bad idea for testing loads of other things.”…
2022-11-25 17:22:37 Common threads between #SARSCoV2 brain involvement and Alzheimer's disease at post-mortem: pattern of neuroinflammation and gene expression, microglia nodule formation, pathway activation, and vascular injury https://t.co/ln41iwTlvG @Pasing01 @IcahnMountSinai @IcahnCMIN https://t.co/UeUh2dOuRV
2022-11-25 16:51:06 Growth curves of BQ.1.1 and XBB in Region 2 (includes New York). The BQ.1s are >
2022-11-25 16:24:49 This week's CDC genomic update shows that 57% of new cases are due to BQ.1/BQ.1.1 variants as BA.5 fades and small increases in a few other variants (XBB, BN.1, BA.2.75) https://t.co/jjl2AnwOWXhttps://t.co/IWoEZFI5Rb
2022-11-25 15:37:26 The molecular mechanism of #SARSCoV2 infection https://t.co/zxLN8q66Rf @ScienceMagazine highlighting the role of endosomes in a prize winning essay https://t.co/l3yukGRZ9B
2022-11-24 19:58:48 The growing body of evidence that the 3 respiratory viruses (Covid, flu, RSV) interfere with each other’s spread, limiting a tripledemic's threat https://t.co/auPadYfbsa @ScienceMagazine by @sciencecohen https://t.co/yUKqrZyNUW
2022-11-24 19:25:13 We're heading to a universal toolkit to engineer cells for diverse applications: cancer, autoimmune conditions, neurodegenerative diseases, repair of injured tissue and organs https://t.co/a1h3N2QCQY This week's @ScienceMagazine special section https://t.co/lPuSGVmA5F
2022-11-24 02:17:36 There is an impersonator of me, a fake account @EricTopol5, that has been reported @twitter @TwitterSupport
2022-11-24 00:21:29 The stigma and discrimination faced by most people with #LongCovid https://t.co/s4EYkgCv10 @PLOSONE by @PantelichMarija @Dr2NisreenAlwan and colleagues https://t.co/F8MdNUYAGd
2022-11-24 00:11:41 "Our results suggest that the development of a mucosal booster vaccine dose should be further exploited to induce a stronger sIgA response." @NEJM https://t.co/OPEaVtZmQT More rationale a nasal vaccine booster and benefit of mucosal immunity to augment salivary IgA https://t.co/JTX8sDrLyV
2022-11-23 23:35:06 This is about the short term outlook only, as I reviewed here https://t.co/DqMJ7LAALu still needed
2022-11-23 22:43:13 A very informative, fun and engaging conversation with @trishgreenhalgh about what constitutes evidence in medicine and the pandemic https://t.co/IaVXavjlC7 W/ @cuttingforstone @Medscape
2022-11-23 17:53:31 On the 1-year anniversary of Omicron’s detection, things are looking up. Worse variants countered by tens of millions of infections, vaccines, and boosters make a difference https://t.co/AsFyGcpFK9
2022-11-23 16:33:10 Japan's 2nd BA.5 wave reaches case peak level of Omicron BA.1 (>
2022-11-22 20:53:31 Vaccine effectiveness vs reinfection, a Denmark nationwide study The reduction of reinfection after primary vaccination was significant for the Alpha, Delta, and Omicron variant periods, ranging from 60-94%, lasting up to 9 months https://t.co/C9gWMfC1Tc @PLOSMedicine https://t.co/5VZq1Hgwk2
2022-11-22 20:46:42 Illuminating new @CDCMMWR repot for real world Paxlovid reduction of hospitalization by ~50% across all subgroups by age, vaccinated status, prior infection, month of infection (proxy for variant) https://t.co/LoMLSPepmdhttps://t.co/oLNscrf5M4
2022-11-22 16:19:46 “Americans have been trained for 100 years to think that the hospital is the best place to be, the safest place. But we have strong evidence that the outcomes are actually better at home.” The hospital-at-home movement is just getting started https://t.co/TnfDzSCeoK @paula_span https://t.co/tvxqFMqwE5
2022-11-21 16:14:51 As of 10 November 2022, it is estimated that 94% of Americans have had Covid at least once, much of those infections in the past year. Ranking of states w/ most vulnerability d/t lack of vaccines/ boosters https://t.co/W5zzyrD0vN @HarvardChanSPH https://t.co/FlY9MqC3Jq
2022-11-21 14:55:09 Unlike the prior 2 holiday seasons in the US, a major surge is unlikely, which is not in keeping with new, dominant variants with marked immune evasion. https://t.co/DqMJ7LAALu However, waning of immunity, poor uptake of boosters, and lack of mitigation sets up vulnerability https://t.co/rEQSBzeewg
2022-11-21 01:21:26 Tumors also can have fungi within them which can, like (and interact with) bacteria, have functional impact on cancer and its therapy https://t.co/KDWV9XjQzW @CellCellPress https://t.co/72eyqbrMq0
2022-11-21 00:03:11 @steveagee Approved in China, India, Iran Big clinical trial in Mexico A company (Ocugen) has licensed the Bharat Biotech (India, IP from @WUSTL) for the United States but there’s no regulatory guidance by @US_FDA yet for Covid nasal vaccines
2022-11-20 23:46:08 RT @EricTopol: My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SAR…
2022-11-20 18:55:24 The consistent increased risk of diabetes after Covid across all age groups, highest in the first 3 months after infection, from a systematic review of 9 studies, ~40 million people https://t.co/uJ5T3ENGrjhttps://t.co/GZzZmhDrfH
2022-11-20 17:54:58 Months ago @VirusesImmunity and I laid out the strong case for nasal vaccines to achieve containment of the virus, breaking the chain of transmission at the individual and population level https://t.co/OujfFxMgU6 @SciImmunology https://t.co/lPGQTC2T1i
2022-11-20 16:23:27 I'm outraged by this pathetic and inexcusable inability for this country to go after nasal and better, durable, variant-proof vaccines https://t.co/u2AErUyYpNhttps://t.co/CuRQ51q8pi
2022-11-20 15:45:21 Why is the outlook favorable when new variants with marked immune evasion and growth advantage have become dominant? https://t.co/DqMJ7LSJZC
2022-11-19 19:46:26 My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SARSCoV2 variant with a marked increase in immune evasion not to have induced a wave. https://t.co/DqMJ7LAALu
2022-11-19 15:20:02 I thought that many bytes should be named helluva but the new name is quetta https://t.co/d77lA6LTc2
2022-11-19 00:57:34 This poses a major concern for immunocompromised who have benefited from Evusheld (preventive) &
2022-11-19 00:57:33 The BQ.1.1 variant, as compared with many of the other new variants, is resistant to all clinically used monoclonal antibodies. BQ.1/BQ.1.1 are now the dominant variants in the United States https://t.co/PCFPSGF2uy @TheLancetInfDis https://t.co/dHucxoGokC
2022-11-18 21:17:45 Good news: 1st drug to alter the course of Type 1 diabetes in 100 years approved by @US_FDA Bad news: it costs ~$200,000/14-day treatment
2022-11-18 20:40:04 @legalnomads BA.1 bivalent induces about half as much neutralizing antibodies vs BA.5 as the BA.5 bivalent (live virus assays), both better than original booster. Whether that translates to any difference clinically is unclear.
2022-11-18 20:12:01 The bivalent BA.1 booster is being use in many countries around the world, but data are limited compared with the original (WT) booster against BA.5. New today: doubling of neutralizing antibodies https://t.co/M2YUB5wpH4 (BA.5 bivalent was ~3-5X WT in several recent studies) https://t.co/xYwnfcXkm6
2022-11-18 18:44:04 How to improve science discovery and productivity? Not just about money (see graph below): funding fast, bets on talent/people, take risk, think big https://t.co/HEAXu2L87H by @greg_ip w/ @patrickc @tylercowen @pdhsu https://t.co/7O6qplOf9C
2022-11-18 18:01:46 @KMunoz46 Correct. That's why there's no good explanation
2022-11-18 17:44:15 RT @ElinSilveous: “Foreign rivals have raced ahead in approving long-awaited nasal-spray vaccines, including one invented in St. Louis, cre…
2022-11-18 17:27:39 Does going to @NFL games increase risk of Covid? https://t.co/UzghLiDCgT Interesting findings of an association in the 14-21 day postgame period when >
2022-11-18 15:54:32 A systematic review of Covid vaccines for kids age 5 to 11 (30 studies) Effectiveness 75% vs hospitalization
2022-11-18 15:45:27 @TopherSpiro46 @AshishKJha46 I know, Topher. Absolutely no reason for refusal of Congress and failure to fund. Appreciate @ashishkjha's strong advocacy
2022-11-18 14:58:07 An explainer for why the US is not pursuing nasal vaccines. TLDR: there is no good explanation https://t.co/Ih6ypzOva7 by @benjmueller w/ @VirusesImmunity @florian_krammer
2022-11-18 03:51:13 @lainemartin1 Very appreciative of your note!
2022-11-18 03:33:22 Refers to BQ.1.1 (see blue arrow)
2022-11-18 03:32:12 New data for why a bivalent booster will help: "These data suggest the bivalent BA.4/5 vaccine is more immunogenic than the original ...vaccine against circulating Omicron sublineages, including BQ.1.1 that is becoming prevalent globally." https://t.co/wAoTyur6be Get boosted! https://t.co/j21g0bELIp
2022-11-18 00:42:08 By current variant growth advantage patterns, the next couple of months in the US will be BQ.1.x dominated. Bivalent boosters will help protect
2022-11-17 23:56:45 A new report confirms the immune escape of the BQ.1.1 variant, along with BA.4.6 &
2022-11-17 23:26:54 We still don't have a way to diagnosis chronic traumatic encephalopathy (CTE) in people who are alive, but may be getting closer https://t.co/SftRQR7TWD by @el_belson @NYTSports https://t.co/BTh6oXUxRg
2022-11-17 21:47:06 RT @rowlsmanthorpe: Long covid has wrecked my life It’s bad, very bad. But you knew that already I want to tell you a hopeful story. A st…
2022-11-17 17:33:41 RT @linseymarr: You get a 2-for-1 with filtration. It removes virus from the air and PM2.5 that is associated with an increased risk of inf…
2022-11-17 17:28:45 RT @Aiims1742: Important #OpenAccess paper in @Cancer_Cell from @CharlesSwanton &
2022-11-17 17:09:54 Strong evidence that particulate matter air pollution (ambient PM2.5) increases the risk of Covid infection, a systematic analysis https://t.co/RueG44Hk2m @MonashUni https://t.co/kpREoqJVPi
2022-11-17 15:46:50 About 1 in 5 of us have an APOE4 gene variant, the #1 genetic risk factor for Alzheimer's disease. But the mechanism for brain injury was a mystery, now getting unraveled (cholesterol processing by oligodendrocytes) https://t.co/gIpGt0CA28 @nature https://t.co/hbmdpO6R3thttps://t.co/4zFZIhUTCI
2022-11-17 01:27:50 @amitsurg Because they do. That's mostly related to the excess of rebound after Paxlovid
2022-11-17 00:58:05 We've (re-)learned a few important lessons from the Paxlovid rebound experience about randomized trials and real world evidence Reviewed here https://t.co/jmT9vIipg9
2022-11-16 19:46:41 The Paxlovid rebound story New data reviewed in the 16 November daily briefing of Ground Truths https://t.co/jmT9vIipg9
2022-11-16 17:48:15 The US Covid death rate (7-day average) drops below 300 for the first time since June 2022. Lowest since pandemic began was 222 in July 2021. https://t.co/Cze8bZgtVrhttps://t.co/uxGosRY1KO
2022-11-16 17:14:12 Immunotherapy can induce myocarditis but the mechanism has been poorly understood. A new report @nature today supports the culprit auto-antigen role of α-myosin and cytotoxic T-cells directed to it https://t.co/uPRUQBbkVh by @MargaretAxelrod @BalkoLab https://t.co/vWZP1IcW19
2022-11-16 16:37:07 Humidity (indoor, relative) is associated with outcomes of Covid infections, a population-based study in 121 countries https://t.co/dWMmyMfBSLhttps://t.co/hW7Jq1mhdo
2022-11-16 01:17:21 RT @PeterHotez: Important and well-conducted study by @EricTopol My take: even though rebound is real and significant, in my conversation…
2022-11-15 23:33:25 For the people pointing out that @POTUS, @CDCDirector and Tony Fauci all had Paxlovid rebound, that's why you do prospective, systematic studies. We've learned that "rebound" also occurs without Paxlovid and that anecdotes/twitter are not representative of the real world
2022-11-15 20:14:34 Each participant did rapid antigen testing every other day through day 15, symptom surveys through day 17, and are being followed for 6 months https://t.co/8bDtswdytR
2022-11-15 20:00:32 The event curves for Paxlovid treated compared with controls https://t.co/2ykeOuBUAX
2022-11-15 19:56:25 Our prospective Paxlovid rebound study with controls preprint is posted By symptoms: ~12% rebound (19% Pax vs 7% controls) By positive testing: ~5% rebound (14% Pax vs 9% controls) Much lower than many estimates https://t.co/czeGEYIJvA by @JayPandit @michaelmina_lab @ScrippsRTI
2022-11-15 16:11:35 Start of new waves in South Korea and Japan, having sustained recent BA.5 waves and this variant still accounts for most new casesThe pandemic isn't over https://t.co/DhwWhZ4CJi
2022-11-15 16:01:28 Here's the article. A potential path to preventing brain tissue from dying https://t.co/ODGuD8X8iy
2022-11-15 00:48:03 Today's pandemic briefing on new booster data and the thick soup of new variantshttps://t.co/LA3nl6FxSx
2022-11-14 17:22:13 RT @danrdanny: Excited to see our work on 3-hour genome sequencing highlighted here! If you think this is interesting we have a bench scien…
2022-11-14 17:04:44 The potential for detecting heart dysfunction (ejection fraction <
2022-11-14 14:37:14 RT @EricTopol: Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so m…
2022-11-14 14:28:16 In aggregate, solid evidence that the bivalent booster elicits a strong and broadened neutralizing antibody immune response. Yet, less than 27% of Americans 65+, the have had it and poor uptake across all age groupshttps://t.co/V5Xlj3cKln
2022-11-14 14:28:15https://t.co/fJbLUdcYJdCoverage @statnews by @matthewherper w/ @SutharLab, whose results were replicated by the new data (Table)
2022-11-14 12:00:01 Moderna BA.5 bivalent booster results announced (via @moderna_tx press release)—largest study to date of >
2022-12-07 20:33:05 "But over the last 30 years or so, I have begun to realize that while RCTs are a brilliant idea for testing drugs, they are a catastrophically bad idea for testing certain other things, masks being one of them."—@trishgreenhalgh https://t.co/IaVXavjlC7 w/ transcript
2022-12-07 18:50:25 RT @EricTopol: The body of evidence we have for efficacy and safety of Covid vaccines is the largest in the history of medical interventions
2022-12-07 17:59:57 The rise in US Covid hospitalizations may surpass the summer BA.5 wave, fueled by waning immunity, lack of mitigation and BQ.1.1 https://t.co/o5ibW11jaXhttps://t.co/Y3Uf6EKC3i
2022-12-07 16:07:37 @JillianHortonMD Thank you!
2022-12-07 15:50:42 The denialism of a new wave extends to the risk of infections and reinfections. "Anyone who doesn’t take seriously the risk of COVID infection is in denial about the risk of #LongCovid and its potentially disabling effects."
2022-12-07 15:40:23 During COVID-19, the US lost more life expectancy than almost any other country as assessed here, #dataviz https://t.co/DIxN3ZrvsK @NatureHumBehav @FortuneMagazine by @Trans_World https://t.co/HSx8SprqVN
2022-12-07 15:27:34 Los Angeles County is the largest county in the US with a population of nearly 10 million people Now with a new Covid surge https://t.co/EM7Ei3cpGB @LukeMMoney @ronlin Cases have doubled and hospitalizations are up 77% in the last 2 weeks https://t.co/2hpenSZ59khttps://t.co/xXBiuekLJi
2022-12-07 14:15:25 The body of evidence we have for efficacy and safety of Covid vaccines is the largest in the history of medical interventions
2022-12-07 23:26:54 France is the 1st country to have seen the BQ.1.1 variant become dominant (now >
2022-12-07 23:11:37 Characterization of the immune evasion and cell entry for the new variants: BQ.1.1, XBB.1, and BR.2.1 (<
2022-12-07 20:33:05 "But over the last 30 years or so, I have begun to realize that while RCTs are a brilliant idea for testing drugs, they are a catastrophically bad idea for testing certain other things, masks being one of them."—@trishgreenhalgh https://t.co/IaVXavjlC7 w/ transcript
2022-12-07 18:50:25 RT @EricTopol: The body of evidence we have for efficacy and safety of Covid vaccines is the largest in the history of medical interventions
2022-12-07 17:59:57 The rise in US Covid hospitalizations may surpass the summer BA.5 wave, fueled by waning immunity, lack of mitigation and BQ.1.1 https://t.co/o5ibW11jaXhttps://t.co/Y3Uf6EKC3i
2022-12-07 16:07:37 @JillianHortonMD Thank you!
2022-12-07 15:50:42 The denialism of a new wave extends to the risk of infections and reinfections. "Anyone who doesn’t take seriously the risk of COVID infection is in denial about the risk of #LongCovid and its potentially disabling effects."
2022-12-07 15:40:23 During COVID-19, the US lost more life expectancy than almost any other country as assessed here, #dataviz https://t.co/DIxN3ZrvsK @NatureHumBehav @FortuneMagazine by @Trans_World https://t.co/HSx8SprqVN
2022-12-07 15:27:34 Los Angeles County is the largest county in the US with a population of nearly 10 million people Now with a new Covid surge https://t.co/EM7Ei3cpGB @LukeMMoney @ronlin Cases have doubled and hospitalizations are up 77% in the last 2 weeks https://t.co/2hpenSZ59khttps://t.co/xXBiuekLJi
2022-12-08 21:41:13 @richardludlow @NatureMedicine @ma_hamer @M_Stamatakis No cause and effect established or asserted
2022-12-08 19:46:05 RT @hholdenthorp: Enjoyed talking to Tony Fauci about the last few years and what lies ahead. Lots of great stuff in here for science polic…
2022-12-08 19:22:32 No problem, I'll code for you #AlphaCode https://t.co/7m41MgwHUM "This result marks the 1st time an #AI system has performed competitively in programming competitions" @DeepMind @OriolVinyalsML Not so fast. What it can and can't do. https://t.co/lasA1mJK08 by @zicokolter https://t.co/QqRYL14VJh
2022-12-08 18:40:15 Why does having a human cell atlas, with single-cell and spatial definition, have such transformative potential in medicine? https://t.co/l1II0q1was by @jennyErood @AidMaart @teichlab @GraphicAnja Aviv Regev @NatureMedicine https://t.co/0ZSvKnYaMg
2022-12-08 16:51:44 The conclusion is worth reviewing —1 minute bursts, 3 to 4 per day —for non-exercisers, there's hope —these finding only possible via ~25,000 people from @uk_biobank, wearable sensors, and #AI analytics —1st research to measure VILPA effects https://t.co/ECoOUmaaOo
2022-12-08 16:45:19 @paulg @NatureMedicine @ma_hamer @M_Stamatakis Yes, correct. 1 minute bursts made a difference, 3-4 per of these per day associated with the protection
2022-12-08 16:34:59 Vigorous intermittent lifestyle physical activity (VILPA), 3-4 minute bursts per day, associated with ~40% reduction of all-cause mortality, cancer and cardiovascular mortality https://t.co/BoGmigjqWl @NatureMedicine @ma_hamer @M_Stamatakis https://t.co/UPx61oh4Gs
2022-12-08 16:19:41 Subsequent development of #LongCovid detected by gene expression during acute infection. Two different patterns related to antibody production to spike protein https://t.co/ZklAmwyk4L @NatureMedicine @noambeckmann1 @IcahnMountSinai https://t.co/7uklWADq7e
2022-12-08 15:18:00 RT @Yale: PODCAST: @thehowie and @hmkyale are joined by Dr. Eric Topol, a physician and writer to discuss his career turn toward genomics a…
2022-12-07 23:26:54 France is the 1st country to have seen the BQ.1.1 variant become dominant (now >
2022-12-07 23:11:37 Characterization of the immune evasion and cell entry for the new variants: BQ.1.1, XBB.1, and BR.2.1 (<
2022-12-07 20:33:05 "But over the last 30 years or so, I have begun to realize that while RCTs are a brilliant idea for testing drugs, they are a catastrophically bad idea for testing certain other things, masks being one of them."—@trishgreenhalgh https://t.co/IaVXavjlC7 w/ transcript
2022-12-07 18:50:25 RT @EricTopol: The body of evidence we have for efficacy and safety of Covid vaccines is the largest in the history of medical interventions
2022-12-07 17:59:57 The rise in US Covid hospitalizations may surpass the summer BA.5 wave, fueled by waning immunity, lack of mitigation and BQ.1.1 https://t.co/o5ibW11jaXhttps://t.co/Y3Uf6EKC3i
2022-12-07 16:07:37 @JillianHortonMD Thank you!
2022-12-07 15:50:42 The denialism of a new wave extends to the risk of infections and reinfections. "Anyone who doesn’t take seriously the risk of COVID infection is in denial about the risk of #LongCovid and its potentially disabling effects."
2022-12-07 15:40:23 During COVID-19, the US lost more life expectancy than almost any other country as assessed here, #dataviz https://t.co/DIxN3ZrvsK @NatureHumBehav @FortuneMagazine by @Trans_World https://t.co/HSx8SprqVN
2022-12-07 15:27:34 Los Angeles County is the largest county in the US with a population of nearly 10 million people Now with a new Covid surge https://t.co/EM7Ei3cpGB @LukeMMoney @ronlin Cases have doubled and hospitalizations are up 77% in the last 2 weeks https://t.co/2hpenSZ59khttps://t.co/xXBiuekLJi
2022-12-08 21:41:13 @richardludlow @NatureMedicine @ma_hamer @M_Stamatakis No cause and effect established or asserted
2022-12-08 19:46:05 RT @hholdenthorp: Enjoyed talking to Tony Fauci about the last few years and what lies ahead. Lots of great stuff in here for science polic…
2022-12-08 19:22:32 No problem, I'll code for you #AlphaCode https://t.co/7m41MgwHUM "This result marks the 1st time an #AI system has performed competitively in programming competitions" @DeepMind @OriolVinyalsML Not so fast. What it can and can't do. https://t.co/lasA1mJK08 by @zicokolter https://t.co/QqRYL14VJh
2022-12-08 18:40:15 Why does having a human cell atlas, with single-cell and spatial definition, have such transformative potential in medicine? https://t.co/l1II0q1was by @jennyErood @AidMaart @teichlab @GraphicAnja Aviv Regev @NatureMedicine https://t.co/0ZSvKnYaMg
2022-12-08 16:51:44 The conclusion is worth reviewing —1 minute bursts, 3 to 4 per day —for non-exercisers, there's hope —these finding only possible via ~25,000 people from @uk_biobank, wearable sensors, and #AI analytics —1st research to measure VILPA effects https://t.co/ECoOUmaaOo
2022-12-08 16:45:19 @paulg @NatureMedicine @ma_hamer @M_Stamatakis Yes, correct. 1 minute bursts made a difference, 3-4 per of these per day associated with the protection
2022-12-08 16:34:59 Vigorous intermittent lifestyle physical activity (VILPA), 3-4 minute bursts per day, associated with ~40% reduction of all-cause mortality, cancer and cardiovascular mortality https://t.co/BoGmigjqWl @NatureMedicine @ma_hamer @M_Stamatakis https://t.co/UPx61oh4Gs
2022-12-08 16:19:41 Subsequent development of #LongCovid detected by gene expression during acute infection. Two different patterns related to antibody production to spike protein https://t.co/ZklAmwyk4L @NatureMedicine @noambeckmann1 @IcahnMountSinai https://t.co/7uklWADq7e
2022-12-08 15:18:00 RT @Yale: PODCAST: @thehowie and @hmkyale are joined by Dr. Eric Topol, a physician and writer to discuss his career turn toward genomics a…
2022-12-07 23:26:54 France is the 1st country to have seen the BQ.1.1 variant become dominant (now >
2022-12-07 23:11:37 Characterization of the immune evasion and cell entry for the new variants: BQ.1.1, XBB.1, and BR.2.1 (<
2022-12-07 20:33:05 "But over the last 30 years or so, I have begun to realize that while RCTs are a brilliant idea for testing drugs, they are a catastrophically bad idea for testing certain other things, masks being one of them."—@trishgreenhalgh https://t.co/IaVXavjlC7 w/ transcript
2022-12-07 18:50:25 RT @EricTopol: The body of evidence we have for efficacy and safety of Covid vaccines is the largest in the history of medical interventions
2022-12-07 17:59:57 The rise in US Covid hospitalizations may surpass the summer BA.5 wave, fueled by waning immunity, lack of mitigation and BQ.1.1 https://t.co/o5ibW11jaXhttps://t.co/Y3Uf6EKC3i
2022-12-07 16:07:37 @JillianHortonMD Thank you!
2022-12-07 15:50:42 The denialism of a new wave extends to the risk of infections and reinfections. "Anyone who doesn’t take seriously the risk of COVID infection is in denial about the risk of #LongCovid and its potentially disabling effects."
2022-12-07 15:40:23 During COVID-19, the US lost more life expectancy than almost any other country as assessed here, #dataviz https://t.co/DIxN3ZrvsK @NatureHumBehav @FortuneMagazine by @Trans_World https://t.co/HSx8SprqVN
2022-12-07 15:27:34 Los Angeles County is the largest county in the US with a population of nearly 10 million people Now with a new Covid surge https://t.co/EM7Ei3cpGB @LukeMMoney @ronlin Cases have doubled and hospitalizations are up 77% in the last 2 weeks https://t.co/2hpenSZ59khttps://t.co/xXBiuekLJi
2022-12-08 21:41:13 @richardludlow @NatureMedicine @ma_hamer @M_Stamatakis No cause and effect established or asserted
2022-12-08 19:46:05 RT @hholdenthorp: Enjoyed talking to Tony Fauci about the last few years and what lies ahead. Lots of great stuff in here for science polic…
2022-12-08 19:22:32 No problem, I'll code for you #AlphaCode https://t.co/7m41MgwHUM "This result marks the 1st time an #AI system has performed competitively in programming competitions" @DeepMind @OriolVinyalsML Not so fast. What it can and can't do. https://t.co/lasA1mJK08 by @zicokolter https://t.co/QqRYL14VJh
2022-12-08 18:40:15 Why does having a human cell atlas, with single-cell and spatial definition, have such transformative potential in medicine? https://t.co/l1II0q1was by @jennyErood @AidMaart @teichlab @GraphicAnja Aviv Regev @NatureMedicine https://t.co/0ZSvKnYaMg
2022-12-08 16:51:44 The conclusion is worth reviewing —1 minute bursts, 3 to 4 per day —for non-exercisers, there's hope —these finding only possible via ~25,000 people from @uk_biobank, wearable sensors, and #AI analytics —1st research to measure VILPA effects https://t.co/ECoOUmaaOo
2022-12-08 16:45:19 @paulg @NatureMedicine @ma_hamer @M_Stamatakis Yes, correct. 1 minute bursts made a difference, 3-4 per of these per day associated with the protection
2022-12-08 16:34:59 Vigorous intermittent lifestyle physical activity (VILPA), 3-4 minute bursts per day, associated with ~40% reduction of all-cause mortality, cancer and cardiovascular mortality https://t.co/BoGmigjqWl @NatureMedicine @ma_hamer @M_Stamatakis https://t.co/UPx61oh4Gs
2022-12-08 16:19:41 Subsequent development of #LongCovid detected by gene expression during acute infection. Two different patterns related to antibody production to spike protein https://t.co/ZklAmwyk4L @NatureMedicine @noambeckmann1 @IcahnMountSinai https://t.co/7uklWADq7e
2022-12-08 15:18:00 RT @Yale: PODCAST: @thehowie and @hmkyale are joined by Dr. Eric Topol, a physician and writer to discuss his career turn toward genomics a…
2022-03-16 17:40:49 Even with lower fatality of Omicron where there's an immunity wall (69% 2-shot, 42% 3-shot), a booster shot reduces mortality 96% https://t.co/fOkipDbOAC @OurWorldInData https://t.co/6lywOwGjUp
2022-03-16 17:07:26 RT @kaitlancollins: Biden announces the U.S. will send drones to Ukraine.
2022-03-16 17:03:46 Today's @nature cover on "oracle," the deep neural network that predicts gene expression from a promoter DNA sequence, trained by tens of millions, paper by @_e_d_v_ and colleagues, link above Art by @MKrzywinski https://t.co/5tSdGuk7u2
2022-03-16 16:42:43 Innovation, just published @Nature You can wear it, machine wash it: the woven acoustic fabric w/ piezoelectric that "hears", picks up heart rate and heart sounds, establishes bidirectional communication https://t.co/9o9naSp1zT https://t.co/VQBw2AJnBS
2022-03-16 16:25:35 For medical #AI, a major bottleneck is having high- quality, annotated image datasets with clinical data and follow-up at scale @pearsekeane @sktywagner @Denniston_Ophth @UCLeye did this for the retina, a window to many medical conditions https://t.co/CD2x6GkRnh @BMJ_Open https://t.co/VCiHlqbVG4
2022-03-16 15:34:22 The Human Pangenome Project https://t.co/eS2AeqWe9B by @rkhamsi @Nature After 2 decades of a foundation based upon 11 individuals, 70% from one man, and genome research desperately lacking diversity, it's time to do this right https://t.co/WrXqy0nbhZ
2022-03-16 14:17:35 RT @josh_wingrove: Here's the video Zelenskiy played for U.S. lawmakers today (via @joshscampbell). https://t.co/UgBhdqX5Ql
2022-03-16 13:29:27 The pattern of American denialism when it comes to Covid, and its new waves https://t.co/dNaNeBm3Lb my latest piece @guardian
2022-03-16 05:31:48 @NicSaldias good way to show it
2022-03-16 02:57:38 Just saw this great 30 second TV ad for boosters https://t.co/FEGC75nIFN Where was it months ago?
2022-03-16 02:09:59 Relative to Hong Kong, it's death rate is very low. Boosters more than double. Great coverage of age 60+ No Sinovac vaccines. BTW Hong Kong's booster 30% rate now exceeds the US (29%) https://t.co/6yWCRc4rvB
2022-03-16 02:03:54 @_j_omara Time from the beginning of the pandemic
2022-03-16 01:58:16 When South Korea, a model country for the pandemic, has > Very high 2-shot vaxx 87%, 3-shot 63%. The pandemic isn't over. https://t.co/X3JKQqvi9S
2022-03-15 23:59:49 "The definition of fully vaccinated now is reasonably three doses."—Edward Mills and @dr_gilmarreis https://t.co/MCIa0lkXqd @HEI_mcmaster @McMasterU @TheLancet today
2022-03-15 21:49:14 @chrislhayes We don't have an up-to-date read on virus sequences from China, but extrapolating from Hong Kong it's likely BA.2. The question is what it will evolve to as it spreads widely...... https://t.co/0e1AmalZGU
2022-03-15 21:38:41 But it's not as simple as BA.2 and facilitators Some countries with BA.2 dominance show the pattern of a new increase in cases Others do not. Case rise without BA.2 or no significant rise with BA.2 https://t.co/t6RYIZYbFE https://t.co/dRlMpCgN8Y https://t.co/KKwFpLiAEV
2022-03-15 19:58:05 The #AI diet 2019 https://t.co/1LxhpaljJL 2022 https://t.co/Q69znO3JlD by @sandeeprtweets https://t.co/BoDyr324Ho
2022-03-15 19:04:15 We once learned that what happens in China doesn't stay in China https://t.co/6q3OC3lWqk
2022-03-15 18:38:27 @CDCMMWR Hospitalizations during the Omicron wave for children less than age 5 were 5-fold higher than with Delta or any other time in the US pandemic https://t.co/AZcOZgRPXO https://t.co/I9SILUk1cu
2022-03-15 17:41:30 This is pathetic. https://t.co/Q50mEm0RtB
2022-03-15 17:35:36 The increase in hospital admissions in many countries with data @OurWorldInData https://t.co/JGNMT66O4o
2022-03-15 17:15:45 The BA.2 triad. The new wave in Europe has 3 inter-dependent underpinnings. BA.2 has ~30% more transmission than BA.1. Less restrictions and more waning immunity will increase that further. https://t.co/saWZm90CXq
2022-03-15 16:57:29 The new Europe wave is gaining steam https://t.co/RUFFyl5Agd
2022-03-15 16:26:46 In December, Israel started a 2nd booster shot for people age 60+ On February 1, they published compelling data for benefit for > https://t.co/06OcNpRCB8 Still no plan in the United States Now this. https://t.co/bHyw5MNtG3
2022-03-15 15:30:56 This is a problem. Use of a drug with very low efficacy (30%) and worrisome side effects due to inadequate supply of Paxlovid pills https://t.co/5xilTwxRnJ by @JaredSHopkins https://t.co/pYlqMnO2H8
2022-03-15 15:03:11 Evidence of small airways disease and air trapping in people with #LongCovid symptoms in a prospective study compared with healthy controls, independent of initial infection severity (small N) https://t.co/yn9WY4PtOy @radiology_rsna
2022-03-15 14:44:28 @ScienceTM Omicron's impact on reinfection in South Africa https://t.co/iPWCQ8bQ73 by @SACEMAdirector and colleagues https://t.co/Eg6RrQB8G0
2022-03-15 14:23:01 Denmark. https://t.co/Q6ar8mFWCo
2022-03-15 14:14:18 The need for booster shots compromised the crucial goal of global vaccine equity https://t.co/OpMGImlFBL @donatopmancini @JamieSmythF https://t.co/tGl7ux0wmP
2022-03-15 03:20:42 Wastewater surveillance of Covid is relatively sparse in the US, but 62 (15%) sites have a > https://t.co/bc8crKZDHu https://t.co/aOSmkR9C7E
2022-03-15 02:01:41 85% of Covid infections were asymptomatic in a prospective, rigorous household South African study w/ 116,000 nasal swabs in 1,200 urban and rural household members. Transmission was the same, irrespective of the presence of symptoms. Pre-omicron. https://t.co/rP4Yi46Jl2
2022-03-15 01:22:37 Great to see US Covid hospitalizations down to 23,000 and approaching their pandemic low But indicators from the new wave in Europe and US wastewater surveillance suggest this may be short-lived https://t.co/lwl6u0a5YL
2022-03-14 22:45:09 Let's see if we can screw it up again. https://t.co/qNB4VzOiXB
2022-03-14 22:42:31 How to be complacent and unprepared. If this stands..... Cancels order for 9.2 million doses of Paxlovid, blatant lack of support improved data/ wastewater surveillance and testing, pan-β-coronavirus vaccine, and other critical public health measures https://t.co/15EUDuy4Ps
2022-03-14 21:57:40 Not just infections. https://t.co/CrmrX75F9j
2022-03-14 21:35:20 That's @NatImmunol (not @NatureMedicine) from @StanfordMed's immunology group @stanfordimmuno Pulendran Lab
2022-03-14 21:29:41 The mechanism of immunity generated by an mRNA Covid vaccine @NatureMedicine https://t.co/6PZHLUkg0d How innate immunity pathways interact with the cellular response https://t.co/N2rhQIM2c3
2022-03-14 20:50:44 What happens in the UK and Europe doesn't stay there. 5 out of 5 warnings predicted what would happen in this US. Let's make believe the 6th won't. https://t.co/BFPpGsZXV7
2022-03-14 18:37:55 Now ranks #67 for 2-shot and #70 for boosters in the world. https://t.co/spNKdMZtvm
2022-03-14 18:37:53 Vaccinations in the United States have fallen to their lowest levels since they were initiated https://t.co/cPQsmihHQt
2022-03-14 18:18:33 Then compare to Hong Kong, with substantially less vaccination protection, 70% 2-shot, 30% boosted, much lower % in elderly for both, and high use of Sinovac, which provides less protection vs. Omicron. https://t.co/B3N6Pn72Oq
2022-03-14 17:43:37 South Korea and Singapore, both 100% Omicron, 90% 2-shot vaccinated, 65% boosted population, demonstrate this strain's virulence and lethality @OurWorldInData https://t.co/oPUQmXYIjv
2022-03-14 17:09:54 A systematic review of 21 randomized trials challenges the very aggressive use of statin LDL-lowering for reducing heart attacks, strokes, and deaths https://t.co/fUskuto7LG @JAMAInternalMed @pbyrne82 @MaryanneDemasi @susanmsmith https://t.co/XzieFVwou5
2022-03-14 16:05:01 Notable exception in people age 65+ throughout the pandemic, not well protected by natural immunity. After 6 months, still a significantly reduced protection, 72% for age 65+, compared with younger age groups https://t.co/Ce14q5VdPV
2022-03-14 16:05:00 Prior Covid (natural immunity) provided pretty strong protection against reinfection. Then came Omicron. https://t.co/TQOQV4SL9a New report from several million people in Denmark https://t.co/Gl09q9iYST
2022-03-14 15:20:26 Vaccination provides substantial protection for kids age 12-17 from infection: Delta (left) and Omicron (right) after 1-shot https://t.co/CRnoTBZWNM @erika_molteni and colleagues https://t.co/BLA6jg5ZCt
2022-03-14 15:01:13 A global record that is surpassed day after day https://t.co/RiFT7NlTdy
2022-03-14 14:50:32 "We argue the lower severity of Omicron is a coincidence and that ongoing rapid antigenic evolution is likely to produce new variants that may escape immunity and be more severe" https://t.co/PwuwYMmYSq @pvmarkov @ArisKatzourakis @NatureRevMicro https://t.co/35weGu27LQ
2022-03-14 07:14:28 Why? Here is the vaccination coverage by age vs Singapore and New Zealand. Also contributing is the high use of Sinovac, for 2/3rd of elderly who were vaccinated, which has reduced efficacy vs Omicron https://t.co/ncS1Vlgrls
2022-03-14 07:14:27 Hong Kong, where every Omicron "Covid case has been between 20 and 50 times more deadly in than in peer countries" https://t.co/Fts5g0mEa4 @mroliverbarnes @primroseriordan @jburnmurdoch @imandylin2 https://t.co/dxR6rHGVFP
2022-03-14 00:52:26 The acid test for Covid vaccines are protection of the elderly. New data from ~900,000 Finns age 70+ show how 3 shots achieved 96% effectiveness vs hospitalization, before and after Omicron, and even higher vs ICU need https://t.co/TQOQV4SL9a Spikevax=Moderna
2022-03-13 22:04:02 @Mike_Honey_ Agree and thanks, Mike. It certainly appears to be contributing, but there are countries with BA.2 sharp rise/dominance without clear case ascension, and a lack of relationship between countries by extent of case and BA.2 rise
2022-03-13 21:20:03 Over the past year, life science is getting transformed by #AI: —Accurately predicting protein structure from amino acid sequence —Accurately predicting RNA structure —Step closer to predicting gene expression from DNA sequence (this week) https://t.co/XXZbhdDAtJ @_e_d_v_ @MIT https://t.co/LxidcX6IGU
2022-03-13 20:25:21 3-shot and 2-shot vaccination % population levels and timing in these countries: lack of correlation with upticks. Same with BA.2 %. https://t.co/fYXULVfJxz
2022-03-13 20:25:19 Why are many countries in Europe starting to ascend again? Relaxed mitigation measures BA.2's higher transmission Waning of immunity There's no clear or consistent pattern to determine which (or all) of these factors are driving it
2022-03-13 19:33:15 What we've learned so far about genetic susceptibility to Covid https://t.co/cU1kmBSb5n, by @danielalamasmd @nytopinion @Mayanazatz @dalygene @casanova_lab https://t.co/aMLutAck9Z
2022-03-13 18:42:45 Tracking new variants, a primer. Yes, there's been a "Deltacron" (fusion of Delta/Omicron components) detected since January but no sign of it having transmission or pathogenicity worries https://t.co/65F3vxgAo5 @donatopmancini @clivecookson w/@Tuliodna @ewan_harrison @sajidjavid
2022-03-13 18:16:04 China's Covid predicament is manifesting in 2 of its most populous cities, Shanghai and Shenzhen https://t.co/4DdH0bv9Er https://t.co/fulBD5UNgW https://t.co/zI8UELCycb
2022-03-12 19:02:41 I wrote this last week, not expecting the new wave to manifest this quickly https://t.co/PEtZXCRkxS
2022-03-12 18:49:39 6. Unlike the UK, which has laid out its plan for a 4th dose, the US has no plan. Just like what happened for the 3rd dose. https://t.co/yYG2cx44gD
2022-03-12 18:35:17 A post-mortem of the pandemic's preventable mortality https://t.co/pIbLWXuLP5 by @zeynep Including a large proportion of more than a million lost American lives https://t.co/ZiOpMjbyh0
2022-03-12 18:19:40 4. No difference in vaccine effectiveness between Omicron lineages BA.1 and BA.2 vs symptomatic disease, but steady decline at 10+ weeks https://t.co/MqA6G0R8F7
2022-03-12 18:19:38 3. Also seen vs hospitalizations by 10+ weeks https://t.co/QYgsHn28Dg
2022-03-12 18:19:37 2. The falloff of effectiveness vs Omicron over time is striking. Here VE for age 50+ against mortality https://t.co/Gyyz7nmVrU
2022-03-12 18:19:36 A review of the latest @UKHSA report https://t.co/qSaguxF5XA 1. Booster shots have prevented about 160,000 hospitalizations in England during the Omicron wave https://t.co/TPb5P4YCq2
2022-03-12 18:00:26 The 1st @czbiohub has done much to advance life science. I interviewed @StephenQuake, its president, about its long-term mission to end human disease as we know it, the expansion to new biohubs, and the exemplary innovative work he's done over many years https://t.co/r8Nj0ZMUzx
2022-03-12 17:23:04 An assessment of the US pandemic's impact 2 years on: the multiplier effect of 1 million lives lost among families, #LongCovid, attrition of the healthcare workforce, and more https://t.co/aD30gZwKPy, by @Edpilkington @guardian https://t.co/TK7DsZely3
2022-03-12 17:15:25 RT @MarkHertling: I said it yesterday on @cnn, I'll say it again today. Having worked w/ UKR's army, I expected them to be very good. And…
2022-03-12 16:46:49 @RogerSeheult Yes, both its BA.1 and BA.2 lineages
2022-03-12 16:42:28 @Tuliodna Great question, Tulio. You may well be right. Waning of vaccine immunity is in the differential, too. May represent all 3 factors at play.
2022-03-12 16:24:04 Among countries that make their data available, some show rising hospital admissions https://t.co/lwT6Owyvjs https://t.co/oNwxsS8rNx
2022-03-12 15:58:47 The next wave in Europe has begun https://t.co/2qm4JzOqit
2022-03-12 15:42:21 This does not bode well for China, relying fully on vaccines with low efficacy vs Omicron. Hong Kong's use of Sinovac is 40%. Both have low booster rates. https://t.co/1tMOafuTXM
2022-03-12 15:17:44 Omicron's lethality in Hong Kong, already at an unprecedented level for the pandemic, is still on the rise https://t.co/crlAwAqEoa
2022-03-12 08:11:00 CAFIAC FIX
2022-01-21 04:03:00 Very similar pattern for age 50-64 44-fold reduction of hospitalization for vaccination Booster benefit consistent,at every time point, but gradient vs 2-shot less pronounced than age 65+ https://t.co/Rzg15Ivz5r
2022-01-21 03:07:17 For the 1st time, @CDC has posted data for hospitalizations partitioned by booster, 2-shots, or no vaccination. Age groups (50-64, 65+) https://t.co/M2Bu9rj1Ve It's Delta, mostly pre-Omicron 50-fold risk for unvaccinated Remarkably low, at times zero/100,000 people, for boosted https://t.co/PykB7hXss7
2022-01-21 01:34:51 RT @EricTopol: I get a lot of questions about "my team" who helps with my twitter posts. Let me make it clear. The "team" is me. >
2022-01-21 00:28:14 @tdietterich @MichaelSmith2nd @UKHSA Indeed. It would satisfy FDA approval for a Covid vaccine
2022-01-21 00:19:59 That's good https://t.co/IGBUwGGJsx
2022-01-21 00:13:29 @Neotas63 @richardhorton1 @TheLancet you mean to block you?
2022-01-21 00:06:47 Q: Do vaccines help protect vs #LongCovid? https://t.co/K3EtYSWyHT @LancetRespirMed A: Yes https://t.co/FFflKeIZKb by @epi_michael and colleagues https://t.co/cRmJo4zKs5
2022-01-20 23:52:51 "An honest appraisal of the past 2 years of pandemic management might include the conclusion that ...there has been an over-reliance on mathematical modelling and too little emphasis on the experience of health workers on the front lines of care." https://t.co/7RYwmzFrMf https://t.co/JzpBjsUv6X
2022-01-20 23:28:23 RT @EricTopol: New: Remarkable 90% and durable protection (>
2022-01-20 22:28:38 This new report adds to the concern https://t.co/cNSV0B7Ji1
2022-01-20 20:36:22 RT @aaas: Writing in @ScienceMagazine, @EricTopol has suggestions for @CDCgov, @NIH, and @HHSGov to improve how they are managing our publi…
2022-01-20 19:40:58 Here are the concordant latest @UKHSA data for 2 and 3-shot vaccine effectiveness vs Omicron hospitalization. An independent replication today, so good to see Kaiser 3 shot, < UK 3 shot, <
2022-01-20 19:29:47 the Omicron spike-ACE complex (with reduced affinity cf prior strains) https://t.co/izgLv5DYYI
2022-01-20 19:29:45 Advances via structural biology throughout the pandemic have been nothing short of incredible. Today the cryo-EM structure of Omicron @ScienceMagazine and .... https://t.co/HcKyrxQZcG https://t.co/nRBbvUbOX4
2022-01-20 19:20:30 Great work by @KPSCalResearch @aboutKP Sara Tartof and colleagues who have been lighting it up for US data throughout the pandemic. Current report is with Pfizer vaccine. As expected, not as high protection (+ waning) vs Omicron for ER visits for booster (yet better than 2-shots) https://t.co/o12YXbogpx
2022-01-20 19:09:08 @DanielSimancasR More great work from @KPSCalResearch @aboutKP Sara Tartof and colleagues who have been lighting it up for US data throughout the pandemic. Current report is with Pfizer vaccine. As expected, Omicron ER visits were not well protected https://t.co/nxgbKmWK3Z
2022-01-20 19:01:00 The neurologic consequences of Covid @ScienceMagazine @SpudichSerena "Many people who experience neurologic symptoms that linger after acute COVID-19 are less than 50 years old and were healthy and active prior to infection" @oooitsplasma @ScienceVisuals https://t.co/rKuGoeArd5 https://t.co/rpgV6c61Ok
2022-01-20 18:59:10 New: Remarkable 90% and durable protection (> https://t.co/5MgpcQp06Y https://t.co/dkaJIma3H4
2022-01-20 17:57:11 What accounts for the differences of Covid in children compared with adults? https://t.co/v6WuOsCuzN @ImmunityCP by @BrodinPetter A very interesting perspective and review https://t.co/rRzGaiJ0aw
2022-01-20 17:49:26 Free access https://t.co/5V9ZeuSceU
2022-01-20 17:19:55 RT @pranavrajpurkar: Today, I am delighted to share our review in @NatureMedicine on AI in Health and Medicine. I am grateful to have work…
2022-01-20 16:40:36 Simulating #SARSCoV2 transmission on long flights: Counting the number of viral copies inhaled by each passenger predicted 84% infectees and uninfected. Masks and limiting conversation between passengers would help reduce risk https://t.co/SAF0UkpFO8 https://t.co/hYLmajGHCT
2022-01-20 16:30:28 The leader of the unwilling and the effectiveness of mandates throughout the world https://t.co/563bcAd239 https://t.co/RvbzvW8r9R
2022-01-20 16:14:58 Our review of #AI for medicine, just published @NatureMedicine https://t.co/OAoAGmErns @pranavrajpurkar, Emma Chen, Oishi Banerjee https://t.co/oufp3nnOob
2022-01-20 15:38:04 https://t.co/uEm4XzTZdR
2022-01-20 15:22:28 "The world got lucky with Omicron. It’s unimaginable what would have happened if that highly contagious variant had caused disease as severe as Delta has. We may not be so lucky the next time."--@JNkengasong @AfricaCDC https://t.co/BIB8bEiC7p https://t.co/LxfpLimr2U
2022-01-20 15:14:34 How's the United States doing on boosters? Trailing a long list of countries, including Serbia, Slovenia, and Lithuania @OurWorldInData https://t.co/cOCVoyuqT3
2022-01-20 14:57:34 "Much better days may be ahead. But as the world has learned over the past two years, only fools with short memories make promises in a pandemic."—@BillHanage https://t.co/yrJEBrkFLr
2022-01-20 14:53:09 A new human organoid model sheds light on Omicron's marked transmissibility with higher replication rate, fitness, and tropism than prior variants for airway, not alveolar lung cells https://t.co/YVDUYOb5mw https://t.co/6hQPkEctam https://t.co/V3rkXyHmHk
++
2022-01-20 04:44:30 @maxdkozlov @SizeMichael @poisondartfrog7 Right, we just don't know what it is yet.
2022-01-20 04:28:21 Why is Omicron so hyper-transmissible? It's not related to high viral load in the upper airway, as shown by 2 recent studies. Contrary to early reports of increased load, up to 70-fold, vs ancestral strain https://t.co/iTpn0WNzLJ by @maxdkozlov So far, it's immune evasion alone
2022-01-20 02:35:50 .@IHME_UW's Chris Murray predicting the end of the pandemic is nigh "More than 50% of the world will have been infected with omicron ...[by] the end of March, 2022" "After the omicron wave, COVID-19 will return but the pandemic will not." https://t.co/9NSw8lZuUe @TheLancet
2022-01-20 00:56:58 RT @K_G_Andersen: Wastewater surveillance is one of the most important tools for tracking COVID-19 waves. Great article @nytimes on the to…
2022-01-20 00:40:53 Neighboring states moving in opposite Omicron case spread directions Wisconsin heading to #1 Michigan now 2nd lowest (above ME) https://t.co/yKYSy65aYt
2022-01-20 00:21:42 Omicron posed no match to Paxlovid https://t.co/IkGC1UIMXj A new lab study report of the anti-Covid pill, woefully in less than scarce availability https://t.co/wVxZwqHcti
2022-01-19 23:54:42 The 3rd shot (booster) neutralizing antibody response to Omicron, and comparisons with breakthroughs (mostly Delta), with and without prior Covid, in a large sample of over 360 participants https://t.co/jXXb7scV0f @MaryYiWeiWu @dremmacbw @DavidLVBauer @TheCrick @TheLancet https://t.co/cUF9O7PPd7
2022-01-19 23:26:01 After South Africa, Denmark was one of the first countries hit by Omicron. There's little sign of any let up, except in ICU patients @OurWorldInData https://t.co/MPz8sRU0AS
2022-01-19 23:12:29 RT @MeaganPhelan: How should science communication change? To gather leading expert views, @hholdenthorp will moderate a plenary discussion…
2022-01-19 22:53:38 What explains this dichotomy of our antibody vs cellular response to Omicron? Over-simplified: Antibodies are not so smart for recognizing its antigenic drift, whereas on-demand T cells and B cells are, and come to the rescue More on this https://t.co/BueHt9PbgD
2022-01-19 22:08:37 The Qatar comparison of 2-shot mRNA vaccines (matched > @NEJM today https://t.co/yyjwoJao2o https://t.co/FN8tvCBCJX
2022-01-19 22:01:00 Just out @NEJM Finally published are the data for the immune response benefit of J& https://t.co/5SRd6LRiyY https://t.co/T3D3ltMG3z
2022-01-19 21:09:48 @JeremyFarrar Agree fully that a variant-specific approach seems low value, perhaps even futile. I'd favor a pan-sarbecovirus vaccine, since we may see further antigenic drift that makes reliance on the ancestral strain a bad bet.
2022-01-19 20:56:15 Omicron's marked ability to evade our humoral (antibody) immune response & This Table summarizes a dichotomy. Our vaccines have weakened vs infection but, w/ a 3rd shot, have preserved, remarkable protection vs hospitalizations and deaths https://t.co/jwGYIOVFCs
2022-01-19 18:50:41 Just published @CellCellPress Good news if you did wind up having an a vaccine breakthrough infection with Omicron: you likely got a potent neutralizing antibody response with increased breadth https://t.co/NY4FyfXZq9 @veeslerlab https://t.co/z87vBo2plv
2022-01-19 17:44:13 @tony_vandongen Nice try. My grants are not for Covid.
2022-01-19 17:36:34 A 16X risk of reinfection for someone with prior Covid to get Omicron (vs prior variants) is striking. Big time antigenic drift. For those relying on "natural immunity" it ought to be a wake up call. Why is that? https://t.co/BueHt9PbgD
2022-01-19 17:31:50 Not Where's Waldo? It's where's Xavier?, as in @SecBecerra @HHSgov https://t.co/SxpGhuEURq regarding @ScienceMagazine editorial https://t.co/SGzbvgZ56l
2022-01-19 17:24:38 Another example of the O-descent wobble Despite that, Spain is doing a great job suppressing hospitalizations, ICU, and deaths with 82% of its population vaccinated, 40% boosted @OurWorldInData https://t.co/W4uB9npjUw https://t.co/FDraqS8mW1
2022-01-19 17:11:24 When Bob asked my about the recent @WSJ oped that said we should deliberately be spreading Omicron, I responded I almost was "tweetless" Since I tweet too much, that might convey how stunned I was to read it (~15 min in) https://t.co/5iYVTaTbjM
2022-01-19 15:31:36 What it took for @RebeccaDRobbins to get her 73 year old mother Paxlovid is inexcusable https://t.co/q6Sbb6HLV4
2022-01-19 14:55:14 Parents, please take note of this important finding on 90% vaccine protection vs MIS-C below. And good to see new data that the recovery of heart function for MIS-C is fairly rapid in most children when this dreaded outcome occurs https://t.co/Jm6vBukm5Z https://t.co/XNJDnpALl9 https://t.co/Op4ITae7dr
2022-01-19 14:19:33 Descents from Omicron waves can be slow, stuttering, and be quite different than initially observed in Gauteng, South Africa https://t.co/Jf1Y99M3yz
2022-01-19 14:12:45 The real death toll from the pandemic is 3 to 5 times higher than what has been reported, and the excess mortality is especially pronounced among low and middle income countries @Nature https://t.co/NSTJ6endB6 https://t.co/y16SliMldf
2022-01-19 13:50:26 @BarakRaveh Thanks, Barak, for flagging these data. Attrition of infection protection with booster over time vs Omicron. Any data yet for hospitalization or severe disease?
2022-01-19 13:46:28 Also confirms marked reduction in loss of smell and taste (~80% less) for Omicron vs Delta https://t.co/5W3OKCwo7G
2022-01-19 13:39:34 New @ONS report The risk of reinfection during the Omicron wave is 16-fold higher than during the Delta wave, further evidence for this strain's marked immune evasion https://t.co/0teRLJLe0b
2022-01-19 03:34:00 @Rossputin @GuptaR_lab Quantified here https://t.co/P1ghWwulh3
2022-01-19 02:49:14 This is happening, too "The Biden administration will announce Wednesday a plan to distribute hundreds of millions of free, high-quality [N95] masks through pharmacies and community sites" https://t.co/rARkne2Ygt
2022-01-19 02:43:10 @Rossputin @GuptaR_lab simple translation: Omicron, unlike prior versions of the virus, can't get into lung cells or GI tract cells as well, which is good (we don't know about other organs yet)
2022-01-19 02:40:10 Guess what's in all these trucks? Rapid @iHealthLabsUS tests, fulfilling about 300 million of the 500M US government order, to be sent out @USPS by request later this month https://t.co/9k8Qp5E7Pc
2022-01-19 02:27:57 RT @DrLeanaWen: "Millions of Americans would have been far better protected against severe disease from both Delta &
2022-01-19 02:18:03 @TiffanyAlaniz @TheLancet @C_Kuhlmann1 You're right. It's an unfortunate and terrible term, which we wrote about @ScienceMagazine https://t.co/k8JKuJs6wX
2022-01-19 01:41:59 18 January Now 3 days in a row, a very good streak to build on
2022-01-19 01:27:57 This was the prophetic 1st cluster of 7 people who had Omicron breakthrough infections despite 2 shots + booster Published @TheLancet today https://t.co/i3g7Eftp68 "booster dose still provides good protection against severe disease caused by omicron" https://t.co/TUDLawU6Rc
2022-01-19 00:20:28 Same with me https://t.co/ZyxQtS9vUY
2022-01-18 23:27:34 Beyond the lungs, Omicron has less tropism and infectivity for the gastrointestinal tract, too https://t.co/EhRYFbrhjM by @GuptaR_lab Along with impaired cell-fusion, inability to use TMPRSS2, and more dependency on the endosomal pathway for cell entry
2022-01-18 21:41:46 How the US botched the boosters https://t.co/SGzbvgZ56l https://t.co/R5JfcCzMuy
2022-01-18 21:05:22 Maybe people will realize that we're very fortunate, given Omicron's extensive immune escape, to have this level of protection from an extra dose of a vaccine directed against a virus from 2 years ago https://t.co/LxfpLimr2U
2022-01-18 21:05:21 Then there's data for age 65+: 94% effectiveness, going to 89% after 10+ weeks https://t.co/FcXR0aNPxF https://t.co/PAcI2led6F
2022-01-18 20:55:58 It seems the people who write the vaccines w/ a booster aren't working against Omicron are completely out of touch with the data I'd consider ~90% effectiveness vs hospitalization pretty, pretty damn good https://t.co/sYt4ygsl7f Especially compared with 44% without a booster https://t.co/y8ixbmG8uH
2022-01-18 18:46:31 @in_timbuktu https://t.co/6aHlqiaG5e
2022-01-18 17:54:49 "The president and leading members of public health agencies have made numerous statements and public appearances throughout the pandemic, but not *a single word has been uttered* about fixing the profoundly deficient data systems" https://t.co/SGzbvgZ56l
2022-01-18 17:26:37 Lab studies of Paxlovid "maintain plasma concentrations many-fold times higher than the amount required to prevent Omicron from replicating in cells" New today, along w/ @Dereklowe's piece on the chemistry & https://t.co/rB78pBcEPT https://t.co/s8IVOxYz0V
2022-01-18 16:29:12 These new findings from @sigallab are consistent https://t.co/odzYrClH3p
2022-01-18 16:13:50 RT @ZekeEmanuel: .@erictopol gets it right: we need better data collection, consistent and unified public health comms, and leadership from…
2022-01-18 16:06:46 Just published @ScienceMagazine Restoration of 3rd/booster dose of mRNA vaccine (Pfizer/@BioNTech_Group) for neutralization of Omicron live virus at 1 month, not achieved with 2 doses https://t.co/mF6hjmf1V7 https://t.co/HVBOlNfIuG
2022-01-18 15:54:50 Testing is at peak levels in 2 of these states https://t.co/ocQzNAgY3v
2022-01-18 15:27:49 It's not too late My editorial @ScienceMagazine today https://t.co/SGzbvgHueN The need for a single, consistent, and unified public message, to fix the profound data deficits, and have @HHSgov @SecBecerra step up https://t.co/cRydQmN1Re
2022-01-18 15:18:39 RT @ScienceMagazine: “With the pandemic far from over, public health agencies must take corrective action: gather and share the data, avoid…
2022-01-18 15:06:27 Omicron cases turnaround in some US states with low vaccination rates is a good sign https://t.co/8nSq7PDzHS
2022-01-18 14:43:00 Further highlighting this dichotomy in Israel Impact of cases vs impact on severe disease/hospital or ICU admits/death https://t.co/W4uB9n7J2Y https://t.co/09ddGDQiHC
2022-01-18 14:34:45 "Omicron infection enhances preexisting immunity elicited by vaccines, but on its own may not induce broad, cross-neutralizing humoral immunity in unvaccinated individuals." https://t.co/WvMt69xN6e @GladstoneInst Implications re: immunity wall built from Omicron infections alone https://t.co/kmceu2lmWQ
2022-01-18 14:23:53 “The spectrum of illness reminds us of other seasonal presentation of illnesses that we commonly care for — asthma, croup and bronchiolitis. It is almost as though Covid has replaced some of the usual actors” The risk for subsequent PIMS is yet unknown https://t.co/tlf3mC3mAS
2022-01-18 14:23:52 Omicron: more pediatric hospitalizations, less severity https://t.co/mt4oK5oJVM "The US under-5s hospitalisation rate has jumped to more than four in 100,000, from 2.5 per 100,000 in December, and is by far the highest rate during the pandemic." https://t.co/uT4HLi789b
2022-01-18 05:34:51 @BigginsMarshall I did, retweeted this morning, thanks https://t.co/KI4EZP3frn
2022-01-18 04:58:08 Last point, which I cannot emphasize enough: 3rd shot protection vs Omicron hospitalizations, severe disease, death is remarkably high, about as well preserved as 2 shots vs ancestral strain, and a very different look compared with VE vs infections https://t.co/sYt4ygsl7f https://t.co/q6TmxMQM7E
2022-01-18 04:45:21 Israel has given a 4th dose to well over 500,000 people (of 9 M population) https://t.co/YtYMEE3lth Testing is aggressive (>
2022-01-18 04:35:31 It falls off pretty fast, this vs Omicron (and Delta) symptomatic infections. So an important unresolved question is whether the 4th dose helps prevents this attrition of VE over time vs symptomatic infection and severe disease https://t.co/ekb2jnLjJx
2022-01-18 04:35:29 Last week @UKHSA published their new data on Omicron and 2 dose vs 3 dose vaccine effectiveness (VE) vs infections https://t.co/sYt4ygsl7f In people w/o prior Covid, the booster approximately doubled VE, the 62% isn't bad (point estimate) But https://t.co/VXGSkqfQp8
2022-01-18 03:47:52 New data mRNA vaccine 4th dose https://t.co/s7Odxdk8hd —HCW, 154 Pfizer, 120 Moderna, + control group —Increase in antibodies > —Little effect on Omicron cases —No data yet for ? severe disease, memory B/T cells, higher or more durable protection —Uncertain benefit/need
2022-01-18 01:07:59 17 January 2 days in a row of decreasing US hospitalizations, very good to see
2022-01-17 23:02:43 Inequities and the neurologic sequelae burden of Covid https://t.co/Y53VOuP36v by @LashNolen @NeuroIDdoc @DrNicteMejia @NatureMedicine https://t.co/bUg6nuooic
2022-01-17 22:50:26 More reasons than protecting vs severe illness to love vaccines vs #LongCovid bonus https://t.co/SR9sEHP27k
2022-01-17 22:44:48 RT @matthewcobb: Fascinating. Genes are expressed in non-neuronal cells of olfactory epithelium and seem to be involved in metabolism of od…
2022-01-17 18:26:25 The most recent data posted on this by CDC is from November, prior to Omicron, in 14 states https://t.co/M2Bu9rj1Ve https://t.co/AWJywQAOP9
2022-01-17 17:58:53 @DFisman Just going with the data, including 7-day rolling averages and testing per capita, that are available. If you have better data to illuminate, please share. Obviously, test availability and restrictions, and unreported rapid testing, are major issues throughout North America
2022-01-17 17:38:19 No, it is not a testing "thing" https://t.co/ajvRG7YBbq
2022-01-17 17:36:56 Helps when you have a lot more % people vaccinated and adopt a #VaccinePlus strategy @OurWorldinData https://t.co/HB71yHWzqQ
2022-01-17 17:34:55 Canada's Omicron wave U-turn https://t.co/paqANPV9ju
2022-01-17 17:13:28 Sorry, @CDCgov. This needed a bit of editing for accuracy https://t.co/EWEVcCSkEE https://t.co/aYUfG5s63b
2022-01-17 16:02:00 Why do some people lose smell or taste with Covid? Genetics may play a role. An association with a genome locus expressed in olfactory mucosa new @NatureGenetics https://t.co/3LPOgb2RNm https://t.co/85OHrmTmJR
2022-01-17 15:40:17 Going along with this yesterday was New York's reduction of 548 patients hospitalized, the most in a day in 9 months. Test positivity is coming down in recent days https://t.co/hSKkK1WvXU
2022-01-17 15:10:09 RT @redouad: Update: Switzerland now reports deaths by booster status. Compared to unvaccinated people, the COVID mortality rate is: • 9x…
2022-01-17 14:35:00 Our covid times :-) https://t.co/3eoCtOWglw
2022-01-17 08:11:00 CAFIAC FIX
2022-01-11 08:11:00 CAFIAC FIX
2022-01-04 03:07:51 Today hospitalizations rose steeply again, >
2022-01-03 23:50:02 New York State is a key bellwether for the US now, w/ the highest case/capita count, higher vaccinated (72 vs 62% US), much prior Covid, test positivity > Hospitalizations are steeply rising, mostly in people unvaccinated (thru 12/20) Not a good look for other states to come https://t.co/oBifyYuSxv
2022-01-03 22:59:09 Thanks to @virusmonologues for the update and prompt for a Table summary
2022-01-03 22:58:16 In just a week, 6 new studies have now reported how T cells, induced from multiple vaccines or prior Covid, hold up quite well vs Omicron (i.e. they exhibit cross-reactivity), which should help protect vs severe disease https://t.co/lWVKlxLMjP
2022-01-03 21:30:37 @virusmonologues @marcus_buggert @rorydevries Thanks, Wendy. I thought I was keeping up, but you're a step ahead!
2022-01-03 21:22:47 And the 2nd one here from @ljiresearch Vaccination induced T-cells vs Omicron well preserved compared with all variants and with 3 different vaccines https://t.co/9uu3pZ8a80 @aetarke @SetteLab https://t.co/KYE8Gdxbua
2022-01-03 21:16:55 This is the 3rd major report, independent replication, that emphasizes the T cells from vaccination or prior infection or both are fully capable of responding to Omicron 1st one here from @virusmonologues and colleagues https://t.co/Em3c3Tt9V2
2022-01-03 21:11:44 The original vaccine-induced T cell response (via mRNA or J& https://t.co/ov8dBZjmiG "current vaccines may provide considerable protection against severe disease w/ the Omicron variant despite the substantial reduction of neutralizing antibody responses" https://t.co/K7XiEgxO6e
2022-01-03 15:59:41 Cognitive dysfunction after Covid vs uninfected controls, total N ~2,000, avg age 37 https://t.co/VfSFHk7ntf "regardless of COVID-19 symptom severity reported a significantly higher number of symptoms of executive dysfunction than their non-infected counterparts" + dose response https://t.co/8dGHnp3sA9
2022-01-03 15:31:25 That's a bit of progress. But it should have been 4 months (many countries, including UK and Canada, have moved to 3 months). Lack of the US sticking to the data leaves many people unnecessarily vulnerable to infections, further promotes spread https://t.co/CNmv7EUYWD
2022-01-03 15:10:44 This was expected, but finally we see 5 months instead of 6 (many months overdue, as backed by the data on waning) "anyone eligible for a booster could get the shot five months after receiving the second Pfizer-BioNTech shot, down from six months" https://t.co/wVjv8CCftt https://t.co/oWoH5Iew8A
2022-01-03 14:51:38 An urgent call for global "vaccine-plus" action @bmj_latest today, by @trishgreenhalgh and >
2022-01-03 14:37:00 Our covid times :-( by @smithtoons https://t.co/0HxXLb6wXg
2022-01-03 06:23:49 RT @calonghurst: 5/ Yesterday @UCSDHealth cared for 16 inpatients with omicron (1 in ICU), 15 with delta (4 in ICU), and another 20+ with u…
2022-01-03 02:30:24 ~100,000 patients with Covid in US hospitals today, rising quickly, isn't good, folks https://t.co/xStmHRzwg2 https://t.co/GHSh1mcQOL
2022-01-02 23:34:51 @lotusctr https://t.co/aKxlzo77cM
2022-01-02 21:31:31 @eliowa Good point
2022-01-02 21:20:44 It's pretty impressive that vaccines directed to the ancestral strain spike from 2 years ago, w/ the virus that's evolved thru >
2022-01-02 20:58:12 RT @ScottGottliebMD: @saletan @carlzimmer @azeen Upper airway infections could be more challenging for very young children than it is in ad…
2022-01-02 18:34:37 A 3rd shot (booster) vaccine has 88% effectiveness (95% CI 78, 93) vs Omicron hospitalization [vs 52% without, @UKHSA] UK booster/100 residents 50% Denmark booster/100 residents 49% US booster/100 residents 21% @OurWorldInData https://t.co/sMaiHqNmmD
2022-01-02 17:56:20 A key driver of breakthrough Omicron infections is time from vaccination. When they occur, the neutralizing antibodies induced are effective (cross-reactive) vs the prior variants https://t.co/9eSdLsdp5w https://t.co/2xOzO17W3D
2022-01-02 17:44:30 So far we've seen reduction in Omicron clinical severity vs Delta, reflecting both immunity wall and instrinsic virus properties, in 2 different populations: Gauteng, South Africa 73% https://t.co/zd1sRl12W9 UK 60-70% https://t.co/gVl5c5o9nl
2022-01-02 15:38:35 Our crack @CDCgov data tracking now reporting deaths and hospitalizations through November 2022 https://t.co/HGyjNwCm0v https://t.co/jZlDABrxTP
2022-01-02 01:04:18 That's a big boost of protection for 3rd dose vaccine vs hospitalization from Omicron infection https://t.co/gVl5c5o9nl Vaccine effectiveness increased from 52% (due to 2-dose waning after 6 months) to 88% after the 3rd dose https://t.co/c63Mpx8ClA
2022-01-02 00:15:26 As the world turns.....vertical the Omicron signature (|) @OurWorldInData https://t.co/LOBiaiBapD
2022-01-02 00:05:17 How our memory B cells, when given a 3rd dose (booster) vaccine, adapt to Omicron https://t.co/zaRO6KUfBp @ragoninstitute @ShivPillai4 https://t.co/TFgPihe4X9
2022-01-01 22:02:12 @thehowie Important bellwether. Most recent New York State data: vaccine effectiveness 94% vs hospitalization https://t.co/snnRe7EaRN https://t.co/LIqFRCUth1
2022-01-01 19:35:00 @antonioregalado Because the high efficacy for remdesivir requires coming to a medical center 3 days in a row for intravenous infusions instead of simply popping a pill (for 5 days, lots of pills). However, the ample supply of remdesivir now should not be overlooked
2022-01-01 19:17:05 Recognizing the phenomenal work of @PeterHotez and @mebottazzi "We're not trying to make money. We just want to see people get vaccinated." @TexasChildrens @BCM_TropMed @bcmhouston https://t.co/yGMZH0OVKx by @mradamtaylor https://t.co/IvJqY0NZpL
2022-01-01 18:46:47 For @NHSEngland, last week Omicron was associated with absence (sick or isolating) of ~68,000 healthcare professionals, representing 5% of the workforce https://t.co/ovLnLVoOWf https://t.co/kLT2v3gkwM
2022-01-01 18:26:02 Hospitalizations and ICU cases Testing ~1/4th of Denmark, 2X US, per capita https://t.co/K2exIWpl4d
2022-01-01 18:26:01 The Omicron wave in Ireland > https://t.co/IVSxECDp6L https://t.co/GvWOSNLxXp
2022-01-01 18:07:00 @EagleMD3 Much appreciated
2022-01-01 18:05:29 Why is Omicron so much more transmissible than Delta and previous variants? Enhanced binding and entering cells in the upper airway may be the explanation Work by @PeacockFlu @wendybarclay11 and colleagues and preprint https://t.co/iMICK4jqyN https://t.co/5TexbyzBHR
2022-01-01 15:56:11 Omicron science makes the front page https://t.co/vpZyzRAKQl https://t.co/cYGpqZPuym
2021-12-31 20:39:23 New York State with 72% vaccinated (US avg 62%) had over 76,500 cases today, and is telling us what can happen across the US, during the Omicron wave, with its sharp rise in hospitalizations https://t.co/JPa2bpJxNI
2021-12-31 20:15:06 Our covid times by @mluckovichajc https://t.co/WrrQ09qpQ1
2021-12-31 20:13:14 RT @Nature: Dennis R. Burton and @EricTopol call for variant-proof vaccines to prepare for the next pandemic, in this comment piece from Fe…
2021-12-31 19:27:20 Two new lab reports on Omicron neutralization, among many findings, show the basis for lack of protection for Prior Covid alone, but superior impact of hybrid immunity https://t.co/cKN35M3K4I @florian_krammer https://t.co/mi0RcKGO9A @EckerleIsabella @MBekliz https://t.co/YTNHkZAD6Y
2021-12-31 18:52:15 “One secret weapon has helped beat every disease outbreak over the last century https://t.co/XIkfgpmQmd In 2 years, the US has done nothing of substance to improve pandemic data tracking https://t.co/vveR9xh7c6
2021-12-31 18:21:44 These 6 studies help us understand the relative sparing of the lungs for Omicron vs prior variants. A nice text explainer by @carlzimmer and @azeen https://t.co/8YswyRxx9V w/ @GuptaR_lab @SystemsVirology @hkumed https://t.co/XAbRHS4xkM
2021-12-31 18:13:30 And in the report quantified: A 60-70% reduction in hospitalization for Omicron vs Delta (even with that marked reduction, the enormous case toll for Omicron translates to a lot of severe disease) https://t.co/0RJSFlcL8m
2021-12-31 18:13:29 Another important finding is the overall less severity of Omicron Seen here in a @jburnmurdoch graph for London ICU https://t.co/ovLnLVoOWf https://t.co/2FlkSPFORP
2021-12-31 17:59:06 The new @UKHSA report today strongly reinforces the benefit of the 3rd shot (booster) vs Omicron for reducing hospitalization: 88% https://t.co/gVl5c5o9nl (this is the 1st time we've seen such VE data for booster vs severe disease) https://t.co/8g2cGcl4eU
2021-12-31 02:47:30 @GPallatuci Just over 130,000 a year ago https://t.co/Vys7Vaw3Jr
2021-12-31 02:41:57 Final count just short of 600K, almost double any previous day through the pandemic Also over 5,500 new hospitalizations since yesterday that gets total up to ~90,000 https://t.co/xStmHRzwg2 https://t.co/z9qt1u3Yzz
2021-12-31 00:24:01 The US confirmed new cases reported today are already >
2021-12-30 23:47:32 @JasonRomano This was on 271 Covid hospitalizations in 6 hospitals
2021-12-30 23:06:05 Vaccines working well in kids 12-17 to prevent hospitalizations: 72.1% in unvaccinated 0.4% in vaccinated (2-doses) That's a 180-fold reduction https://t.co/raeT65gbM6 new @CDCMMWR
2021-12-30 22:15:54 Updated the Table with the 6th study. It's rare to see such consistency. And in this case quite welcome https://t.co/PdpOjohxiJ https://t.co/qQ2eh77lYG
2021-12-30 21:54:18 Another report today @JAMA_current from 49 acute care hospitals in South Africa with similar findings for the Omicron wave —reduced clinical severity compared with the first 3 waves https://t.co/7koQ4I7suu https://t.co/R2jCLDm2E3
2021-12-30 20:57:57 The remarkable safety of > https://t.co/2hBYfxyYFr @CDCMMWR https://t.co/CZaq2Bh6Cb
2021-12-30 17:46:37 O signs (|) all over the world (here 4 continents, 20 countries) as Omicron continues on its path to global dominance https://t.co/HMeKgTHtZ1 @donatopmancini @jburnmurdoch @stef_palma https://t.co/21mQPghMcl
2021-12-30 17:38:20 Now a 6th study in both Syrian hamsters and mice with marked reduced pathogenicity for Omicron vs Delta and other variants https://t.co/x79PTUuSBV https://t.co/PdpOjohxiJ https://t.co/a6iZMXlymD
2021-12-30 17:12:21 With Omicron, there's been the emergence of 2 different camps with opposite perspectives. I've tried to summarize them here https://t.co/UAQ2hqo4Eo
2021-12-30 16:05:06 This, too, to note https://t.co/LhtC68DAME
2021-12-30 15:50:22 A good omen for Omicron from its 1st epicenter in Gauteng, South Africa https://t.co/zd1sRl12W9 The reduced clinical severity compared with the 1st 3 waves, and vs Beta and Delta variants https://t.co/aNqhedHdNh
2021-12-30 15:24:44 Childhood vaccinations in Europe. The US is < https://t.co/5TW0fnRGeS @labboudles @hannahkuchler @mroliverbarnes https://t.co/1wgM8OHk97 @CarlODonnell26 @aaboulenein https://t.co/HfZhofM4cH
2021-12-30 13:58:57 Updated fatality rates by state vaccination % @nytgraphics https://t.co/X5b51E3y6T
2021-12-30 13:49:04 In the United States, since all adults were eligible for vaccination in April, there have been nearly 1,000 deaths a day, >
2021-12-30 13:38:45 What is "fully vaccinated"?https://t.co/YkLL2Pt89z by @EmilyAnthes @noahweiland https://t.co/7d6qOAaLRp https://t.co/VTncfMiVIh https://t.co/FEIHV2t46E
2021-12-30 13:19:53 For Omicron wave in South Africa, 2-dose J&
2021-12-30 05:43:37 Maybe someday @CDCgov and other gov't leaders who are currently saying testing won't help can explain why 4 days prior to the new shortened isolation guidelines they issued guidance for healthcare workers *with a negative test result* https://t.co/m2IkuhCA2w
2021-12-30 01:52:24 We also very quickly jumped to over 84,000 Covid hospitalizations https://t.co/F0PlWbiifQ https://t.co/wo8c7h2qbg
2021-12-30 01:48:49 That doesn't look good https://t.co/WPr9ssdRsI
2021-12-30 01:17:35 We thought the anti-Covid pill Paxlovid (Nirmatrelvir) would be effective vs Omicron because there are few, if any, mutations in the main protease of the virus in variants. But good to see this confirmation of potency in an independent lab (not Pfizer) https://t.co/HyCaYtBVRA https://t.co/d5EQMKE2OZ
2021-12-29 22:23:40 RT @nickmmark: Twitter removes notorious spreader of misinformation. Almost everything this guy said was untrue, beginning with his Twitter…
2021-12-29 22:01:00 Just published @NEJM Vaccine effectiveness (Pfizer, 2-doses) vs hospitalization was reduced from 93% (CI 90,94) during the Delta wave to 70% (CI 62,76) during the Omicron wave in a large health system in South Africa https://t.co/AQ2zej88RB
2021-12-29 21:14:28 From @virusmonologues (Prof Wendy Burgers) and the extraordinary team of South African scientists who have been a lighting it up throughout the pandemic, the deets on this report https://t.co/39UDHqfZuI
2021-12-29 20:21:52 @Antonio_Caramia Fully recognize the surge in hospitalizations. I didn't write that there wouldn't be severe Covid. Just that it looks like it will be reduced, related to both Omicron's intrinsic virulence and the immunity that has been built.
2021-12-29 20:14:52 A new study of 2 breakthrough infections with Omicron (OP1 and OP2) shows there was broad cross-immunity to all prior variants of concern, an independent replication of @sigallab's report (and good to see) https://t.co/P0HThQakDy https://t.co/la582VpZvL https://t.co/SdkMnGvQFf
2021-12-29 19:19:17 "Incidental Covid" https://t.co/FxsrcmlUcv A dream for the future. An increase of these in the present @MarcSantoraNYT and @meganspecia https://t.co/KzEUPzSdjp
2021-12-29 19:16:50 @profshanecrotty Thanks, Shane. Just on the papers that are highly relevant and/or impactful. Congrats to you and your group (again)
2021-12-29 18:31:48 5 Studies, 5 Figures. All consistent, independent replications in vivo, in vitro. Omicron can't infect lungs or lung cells as well as prior variants. @KU_Leuven @SystemsVirology @GuptaR_lab @hkumed @LivUni https://t.co/X9jbugx0vs
2021-12-29 18:06:00 With yet another in vivo study of Omicron infection today, it sure is looking that this variant has less virulence, less chance of inducing Covid pneumonia New report: https://t.co/6gj5WmCpRt Added to our immunity wall and T cell defense, this is all good. https://t.co/qhc767nuCK
2021-12-29 17:24:22 A 2nd report today from @ljiresearch also demonstrates vaccination induced T-cells vs Omicron (B.1.1,519) well preserved compared with all variants and with 3 different vaccines https://t.co/u9chjMohFs @aetarke @SetteLab https://t.co/Em3c3Tt9V2 https://t.co/cAQLqRS0RB
2021-12-29 17:05:22 High rate of asymptomatic carriers noted with Omicron as compared with prior variants, with high viral nasal titers in many carriers, adds to its rapid spread capability https://t.co/m0VFAmmvF1
2021-12-29 16:05:11 RT @michaelmina_lab: Not surprising, UK Gov put out an announcement that offers useful info about their evaluation of rapid tests for Omicr…
2021-12-29 15:59:21 RT @angie_rasmussen: I respect Dr. Fauci enormously, particularly for his candor. In the same spirit, I think this line of reasoning is bul…
2021-12-29 15:22:55 A study of nearly 12,000 households in Denmark shows a marked reduction of Omicron transmission among people who had a 3rd (booster) shot https://t.co/gUPW6UCvpm https://t.co/NjQPymxIG7
2021-12-29 15:09:11 Our T cells appear to be ready, willing and able to defend vs Omicron https://t.co/VA2AZW3Jhl CD4+ and CD8+ cells hold up well in people vaccinated or prior Covid https://t.co/nK9l63vDSA
2021-12-29 14:23:55 Exhibit A, by @ravenscimaven https://t.co/981f2dtikT
2021-12-29 14:23:54 I don't buy the excuse that @US_FDA didn't specifically authorize rapid antigen tests to assess whether a person is still infectious and help guide isolation time. This is precisely how the tests are used in the UK and elsewhere. https://t.co/G1JzTffoEg https://t.co/vC3Py63ltY
2021-12-29 03:36:14 @CarolynCannu @CDCgov Sorry, Carolyn. Will work on that tomorrow
2021-12-29 03:13:42 Today in the US > https://t.co/xStmHRzwg2 https://t.co/R6WwPDwsCo
2021-12-29 02:17:40 @drcharitydean I almost put in the metaphor about watering the plastic flowers from The Premonition book that featured your remarkable career in public health
2021-12-29 02:12:24 @atlmammo @CDCgov @SubstackInc Good point. Thanks for noting that
2021-12-28 23:49:46 I wrote about the very bad day at @CDCgov and hope/need for a rapid turnaround https://t.co/NluMfayPTb @SubstackInc
2021-12-28 20:36:12 Data from London's Omicron experience that replicates much of what we had seen in South Africa regarding uncoupling (cases vs severe disease), less severity, less need for mechanical ventilation, rapid ascent/descent https://t.co/2W6WrJnYUG
2021-12-28 20:08:18 BTW The slide also sums up all of the data we have for Omicron shedding and clearance time, in vaccinated or unvaccinated people. Zero.
2021-12-28 19:48:47 Imagine if we tested like Denmark, UK, Israel.... https://t.co/c0Hp24zQny
2021-12-28 18:59:31 @JillEngel12 @CDCgov I think you missed the point
2021-12-28 18:38:58 I cannot understand why there has not been aggressive pursuit of nasal #SARSCoV2 inhibitors or vaccines, like this one, highly effective vs Omicron, to help block transmission https://t.co/o0zAxf03Y2 @helsinkiuni https://t.co/psuGwxjdgr
2021-12-28 18:06:14 The increased risk of breakthrough infections among people with immune dysfunction https://t.co/cpAGGMziPf @ncats_nih_gov BMT-bone marrow Tx, SOT-solid organ Tx @JAMAInternalMed https://t.co/siFLkwkAcj
2021-12-28 16:25:28 Omicron and an expanded Y-axis https://t.co/oqXuqMoG2a
2021-12-28 15:56:56 RT @MoNscience: Omicron got me, fam... ...and I can testify that "mild-to-moderate" symptoms probably feel worse than you think. My jou…
2021-12-28 15:10:30 The @CDCgov is on a roll https://t.co/mgYYQhPkSj
2021-12-28 14:50:38 The data that supports the new @CDCgov 5 day isolation period without a negative test https://t.co/eRIwgGFd01
2021-12-28 14:38:50 Big congrats to my friend @PeterHotez and @TexasChildrens for the approval of Corbevax, their low cost, recombinant protein subunit Covid vaccine in India https://t.co/qZIWQse2Nk
2021-12-28 03:05:10 @eric_seufert It was linked. Here's the graph https://t.co/70qgvkpirG
2021-12-28 02:57:13 There's backlog in the > https://t.co/xStmHRzwg2 https://t.co/IdAjXlPZ1q
2021-12-28 02:43:41 RT @drsanjaygupta: While these are no substitutes for vaccination, @EricTopol notes these drugs are important because they don’t revolve ar…
2021-12-27 22:52:51 This is especially good news, and nicely explained to boot https://t.co/uuFARiOM2U
2021-12-27 22:26:30 I found out today that it takes only 3 people https://t.co/xStmHRzwg2, led by Gérard Hoeberigs, to post data promptly every day for each US state — including hospitalizations, ICUs &
2021-12-27 21:53:01 RT @ScottGottliebMD: Hard to believe a public health agency is running a campaign to drive vaccination by scaring people about cost of seek…
2021-12-27 21:49:03 In these 2 weeks, hospitalizations have already increased > https://t.co/ZwOWW0T3T5 https://t.co/9fV83BdL8Q
2021-12-27 21:22:42 Similar results in this new @CellCellPress report, and extended to Moderna, J& https://t.co/0mivRXO2dE https://t.co/EvogoiTrTE
2021-12-27 21:10:46 Just published @NatureMedicine https://t.co/xBCQMgKFdv Omicron evading neutralization of 2-shot mRNA vaccine or prior infection, but yields to 3-shot or Prior Covid + 1-shot (hybrid) https://t.co/gR5mN60Xop https://t.co/30w7Y6sl0j
2021-12-27 20:32:35 Puerto Rico went from < Even if only a small % get very sick...... 28% of residents are unvaccinated (and that's lower than 45 US states) Respect Omicron's potential for harm.
2021-12-27 19:44:44 Throughout the pandemic, Puerto Rico prevented outbreaks better than any US state. Then came Omicron. https://t.co/D8FpIsWR3W
2021-12-27 18:42:59 The 3rd vaccine shot (booster) substantially helps protect against Omicron symptomatic infections (VE ~70-75%). A mechanism for this may be related to the breadth of memory B-cell response, not seen from a 2-dose vaccination https://t.co/NsAJscbeyJ https://t.co/OeiYSYA2jH
2021-12-27 18:00:17 Despite encouraging lab and animal studies on Omicron's potential reduced pathogenicity, there's still plenty to worry about, especially in the US —70 million people unvaccinated, including children —the immunocompromised (> —the unknowns re: #LongCovid https://t.co/LqjwRvb6To
2021-12-27 17:06:21 Now a 4th study, also in the Syrian hamster model, shows markedly diminished Omicron replication, infectivity, and pathology in the lungs compared with the D614G strain @KU_Leuven https://t.co/4wDGIJiP5W https://t.co/YTX9bsv4dm https://t.co/un66c5poUv
2021-12-27 16:13:06 Every week @UKHSA publishes an extensive report on variants, transmission, vaccine effectiveness, and more. https://t.co/zHOMTzlICN As do many other countries. Here is the @CDCgov report full content https://t.co/W7ev3Gzy3x
2021-12-27 14:52:32 Our covid times :-( https://t.co/Mh1puoIlse
2021-12-27 08:20:00 CAFIAC FIX
2021-12-21 05:49:12 RT @megtirrell: A look ahead at medicine in 2022, with some help from @EricTopol &
2021-12-21 04:07:29 With an infographic https://t.co/cbpW9APG1V
2021-12-21 03:33:05 A new, outstanding review of diagnostic tests for Covid @TheLancet: PCR/molecular tests, rapid antigen and antibody assessment, and how they should be used https://t.co/Qiawu0SCi0 https://t.co/w4u5S74GXb
2021-12-21 03:22:46 RT @DrTomFrieden: I've worked on infectious disease outbreaks for 30 years. I've NEVER seen anything like the speed of Omicron. It's as inf…
2021-12-21 02:16:47 Covid in the US today, reported: --First Omicron death (unvaccinated man in Texas) --Over 268,000 new cases (excluding backlog) --> --Over 67,000 hospitalizations (from Delta) https://t.co/sVE3J1k2Tp
2021-12-21 00:24:00 Just published @TheLancet The waning protection after 2-doses of AZ vaccine became evident at 3 months vs hospitalizations and deaths among > https://t.co/rHvlyo2oeZ https://t.co/segFzYgQB1
2021-12-20 23:30:22 BTW that was as of Saturday. Wonder what it is 2 days later? https://t.co/jjl2AnOqlx https://t.co/98FRSc6B06
2021-12-20 23:22:29 Good context. To add, credit the increase in US sequencing in recent weeks to get on top of this , the Omicron wave. When will @CDCgov collect and report data for hospitalizations by sequencing and vaccine status? https://t.co/ClxpnuLUSu by @MikeStobbe @CarlaKJohnson @AP https://t.co/xTgidNA5hS
2021-12-20 23:16:29 Yes, you read it right, a whopping 73% https://t.co/YudB468Dvd
2021-12-20 22:50:29 Last week's 2.9% of cases being Omicron has been revised upward to 12.6% 12.6% --> That's what you call exponential growth, folks
2021-12-20 22:48:36 Last week @CDCgov reported Omicron was 2.9% (that has now been revised) *Today it is 73%* Dominant across the US (with heterogeneity) This is a doubling growth rate of 2 days or less Replicates what has been seen in South Africa, UK, Denmark https://t.co/enQ5wazT8G
2021-12-20 22:28:35 New @AnnalsofIM 2-shot mRNA Vaccine effectiveness in over 1 million Veterans average age 69 with matched 1 million unvaccinated Effectiveness vs infection 69% Effectiveness vs death 86% https://t.co/esuZah4Elg https://t.co/riHb3bDRMk
2021-12-20 18:57:02 More on this from @JamesWard73's "hopium" on hospitalizations and possible signal of less severe Omicron illness https://t.co/3LVOMS4ZEv
2021-12-20 18:40:32 Good news from London, an Omicron epicenter https://t.co/zLo7slxrjA
2021-12-20 16:42:37 RT @NYMag: "One of the important things will be determining whether people who were vaccinated and got Omicron clear quickly so they’re not…
2021-12-20 15:57:19 Negative rapid test, then Covid positive? My friend @michaelmina_lab's graphic adapted @FT by @jburnmurdoch https://t.co/bbfENh3PjN https://t.co/jJYMaLADv1
2021-12-20 14:24:51 Waning of vaccine protection over time, during the Delta wave in the US, associated with increase in Covid cases across all age groups and increase in deaths among age 65+ shown below https://t.co/j0lhKt8vIv but there was a 2 month delay in recommending boosters for all adults https://t.co/9qmGxbQWuS
2021-12-20 13:50:02 "Reformulation of existing mRNA vaccines to target Omicron may not be necessary with a 3-dose regimen" and lab characterization of its spike properties (reduced receptor binding, cell-cell fusion, but increased cell-to-cell transmission) https://t.co/IVjfJzc3ts https://t.co/SkmjBSq6XB
2021-12-20 13:27:10 Data presented this morning https://t.co/jK0vMFYEOF https://t.co/mkAbb9rNUz
2021-12-20 10:01:00 New lab neutralization titer data vs Omicron for Moderna vaccine booster (sera from 40 individuals vs pseudovirus, 1 month later) @moderna_tx 50 μg ~37-fold increase 100 μg ~83-fold increase (that's very high) Raises question as to optimal booster vs Omicron going forward
2021-12-20 03:14:47 There are also these 2 lab studies of diminished lung cell infectivity for Omicron compared with Delta, a *possible* mechanism for a difference in this variant's intrinsic activity https://t.co/UGnVe0MPK5
2021-12-20 03:02:16 Loss of smell and taste symptoms were hallmark of Covid and still prominent for breakthrough Delta infections. What about Omicron? It seems particularly unusual in confirmed cases and may be a telling indicator of this variant's pathogencity
2021-12-20 01:12:52 Making sense of Omicron @NPR My conversation with @SachaPfeiffer @npratc Where we stand and why there's room for some optimism, with many caveats https://t.co/mcc4viznlN
2021-12-19 22:39:23 Updating this to now more than 6 million children and >
2021-12-19 21:42:58 Covid 19, now Omicron: Where do we go from here? @TheLancet "The USA provides a potent demonstration of the structural barriers and stymied progress in COVID-19 that can originate from political obstacles to health." https://t.co/auilppSSSf https://t.co/5S7Oo3bTUb
2021-12-19 21:28:56 Today's report on Omicron (vs yesterday) Hospitalizations increased from 85 to 104 Deaths increased from 7 to 12
2021-12-19 21:24:25 Denmark is also a world leader in sequencing the virus Today's @SSI_dk report Most Omicron cases in age group 20-29 Omicron hospitalizations increased by 30, 5 less in ICU https://t.co/OAckf5R7HW (in English) https://t.co/YHE5NLfS8X
2021-12-19 20:47:32 @HIVTox Thanks, but I can't translate it. Please elaborate.
2021-12-19 20:35:09 Denmark is an important window for tracking Omicron, w/ its extremely high testing rate (35/100K Today's data (yes, weekend, nonetheless) are fairly encouraging https://t.co/h9u7qjr2dr Missing—hospitalizations, by variant &
2021-12-19 20:14:18 For a graphic review and links to some of the abundant evidence, the first 3 in the thread below https://t.co/uylNYmTk3y
2021-12-19 20:02:05 The evidence for all adults benefiting from boosters was unequivocal well before Omicron https://t.co/1X7qisBZJP @PostOpinions w/ @mtosterholm https://t.co/2yaGgexpZf
2021-12-19 19:30:40 New data posted @CDCgov thru November 20th: 1. strong protection of vaccination vs infections 2. the impact of their 2 month delay for recommending boosters for all adults: a 2.8-fold rise in cases https://t.co/HGyjNwTXp5 in 17 jurisdictions https://t.co/mJqfP8Fiya
2021-12-19 18:50:01 Same here O = | https://t.co/gSTcdP13WZ
2021-12-19 18:31:04 @NIHDirector @genome_gov Our deepest thanks to you, Francis, for your remarkable leadership @NIH all these years, and for many prior to that @genome_gov. Your contributions to advance life science and the steady stewardship you have provided for decades are inimitable.
2021-12-19 01:26:28 Dr Fearnley's warning https://t.co/uxCu3AJRaW
2021-12-19 01:14:25 @MartyManley Thanks for posting this. I, too, very much want to see this Administration succeed. Dealing w/ Delta &
2021-12-19 00:51:24 @meghanor @NYMag Many thanks
2021-12-19 00:24:39 You wouldn't need to sequence the virus in Eswatini to know which variant it is https://t.co/XWSow0fsu7
2021-12-19 00:10:54 Of the 4 countries with highest documented Omicron case burden, Denmark looks like the outlier. But if you consider their current testing levels, they're pretty similar @OurWorldInData https://t.co/SCzIMBkrFd
2021-12-18 21:01:30 We really got into Omicron, immunity, vaccines and the anti-Covid pills https://t.co/p7PVywNkS5 @AspenInstitute w/ @celinegounder @theodora_nyc @DrOnyemaOgbuagu @AaronFMertz @KiraPeikoff @leaps_org
2021-12-18 19:34:50 RT @Bob_Wachter: This is one of the most confusing times of the pandemic, w/ a firehose of new Omicron data (lots of fab work on #medtwitte…
2021-12-18 18:42:28 Paxlovid will likely get EUA before year end (already has in Europe) but there are only 200,000 packs ready. That’s not going to cut it. With the >
2021-12-18 18:08:33 Until now, we’ve fully relied on immunity to counter the virus. With Omicron and further evolution, it’s time to make this anti-Covid pill a priority. I would enact the Defense Production Act to get pills made at scale and not rely on one company https://t.co/Yrs5UBSPNK
2021-12-18 16:34:40 RT @NYMag: "One of the important things will be determining whether people who were vaccinated and got Omicron clear quickly so they’re not…
2021-12-18 15:55:49 @eliowa @evolutionarypsy @MitchKSmith Oh. Let's negate (make believe the data doesn't exist) on the 90% reduction in death age 50+ and marked reduction of hospitalizations age 40+ for 3 shots vs 2 shots https://t.co/Q9c5LXYYJx
2021-12-18 15:48:14 The overall picture for Omicron may well be less severe than prior strains but we're already seeing more hospitalizations and deaths attributed to it @UKHSA 20 more hospitalizations and 6 more deaths since yesterday https://t.co/4hzJQMJFYP It is *not* benign, folks. Get boosted. https://t.co/DIsvEQ8hpA
2021-12-18 15:14:10 How did the American Indian and Alaska Native population achieve the highest vaccination rate of any racial or ethnic group? Ingenuity. Resourcefulness. Innovation.Autonomy New @NEJM https://t.co/e7EkkknVa4
2021-12-18 14:58:54 We've had nearly 2 years to get Covid testing right in the United States, but it's still a blatant failure https://t.co/3Ue2aG86RN by @SherylNYT and @SharonLNYT with my critique about rapid antigen tests https://t.co/fniF3TzfVh
2021-12-18 14:48:28 We'd all like to be an "elite neutralizer" of #SARSCoV2 but only rare people make ultrapotent antibodies, which can be the basis for making a pancoronavirus vaccine. A new bNAb discovery here active vs all variants assessed https://t.co/Bv0Pc3Dyqj New @cellhostmicrobe https://t.co/BIBPTzaLyf
2021-12-18 14:28:39 And we are far behind Only 1 in 6 Americans boosted Data shows that 2-shot waning is clearcut by 4 months but the US sticks to a 6 months booster policy, leaving so many people vulnerable https://t.co/DAdDgOdkgg by @ShawnHubler @amy_harmon
2021-12-18 14:18:58 If you needed more proof in https://t.co/gOl6QNfYjN by @MitchKSmith (during Delta wave) https://t.co/VTncfMiVIh https://t.co/sSrKORynJA
2021-12-18 03:32:21 RT @DrTomFrieden: A tidal wave of Omicron will hit the US and other countries at the worst possible time—holidays approaching, health syste…
2021-12-18 02:44:18 Highest number of confirmed cases in New York State for the pandemic, >
2021-12-18 02:03:05 Follow up of the 1st US Omicron superspreader event @Cornell, among students who were 97% vaccinated, now > by @AnilOza16 @cornellsun https://t.co/uBzMdc7FUz https://t.co/JFYjuORxwD
2021-12-18 00:15:29 @Atul_Gawande Congratulations Atul! We need you on this
2021-12-17 23:30:29 Didn't know what to make of the 1st report on this But it's great to see an independent replication
2021-12-17 23:23:44 Importantby Ravi and his team Omicron-> https://t.co/4PO3uPERLC Which, added to immunity wall of vaccination, would help reduce potential of Covid pneumonia https://t.co/r2SeXXxIoV https://t.co/EvvPgO8I2s
2021-12-17 22:33:04 Current Tests/population @OurWorldInData 9-fold difference Denmark 34,616 per million United States 3,816 per million
2021-12-17 21:32:10 Denmark today: 11,194 cases (yesterday 10,000), likely now Omicron dominant, highest per capita case load in world, over 1,400/million (very high % testing country). 2nd now is Switzerland 1054/M. Good news to date: Very low fatalities https://t.co/ascRkv4tGK
2021-12-17 19:56:36 RT @DFisman: A few thoughts on emerging data around omicron variant. As noted by @EricTopol, case increases in countries with high fract…
2021-12-17 19:41:44 Omicron has already become dominant in England (>
2021-12-17 17:20:15 Here's the actual report https://t.co/kgUvI2Sjny Very small N of hospitalizations 11X reinfection risk vs prior variants Old adage emphasis: Absence of evidence is not evidence of absence. Overall picture is less severity with muliple confounders https://t.co/PGuKKCBnYE
2021-12-17 16:59:50 Latest @UKHSA risk assessment https://t.co/jf3JL3cz6f
2021-12-17 16:52:32 "There are insufficient data to fully assess severity, which is expected in the early period of emergence of a new variant"
2021-12-17 16:44:47 New @UKHSA Omicron report https://t.co/DGHcQ007s2 Exponential growth continues, ~3-fold X Delta for household contact transmission, reinfections vis prior variants https://t.co/tkrzTHigrU
2021-12-17 16:34:15 There's no room for complacency vs Omicron. We have the tools to ante up. Using them will help prevent cases, illness, and #LongCovid, at the very least https://t.co/HBNlNeAb0v my oped @latimes https://t.co/udfRMeiS0R
2021-12-17 15:29:54 @ChrisTeso It’s still early and the data from Denmark are more concerning. There are many confounders, but my sense is that less severity is real, but has little or nothing to do with the virus, per se. More here https://t.co/RcblLn7ZFa
2021-12-17 15:06:53 New vaccine effectiveness data over time from Qatar on Moderna in 880,000 vaccinees vs symptomatic infections https://t.co/MwRafq0ZAo https://t.co/loQscuHyC0
2021-12-17 14:46:16 The field of pharmacogenomics refers to matching a treatment with a person’s genomic data We didn’t have a “viro-genomics” precedent, whereby the treatment is matched with the virus’s genomic data
2021-12-17 14:36:27 Very important point. First time sequencing of a virus linked to optimal treatment, and the supply of Sotrovimab, the only monoclonal effective vs Omicron, is limited https://t.co/yV4ZTKoVvt https://t.co/W9TEghY8pk
2021-12-17 13:55:23 Some additional information on this here https://t.co/Xu1usRipx8
2021-12-17 13:46:39 No evidence that Omicron is less severe, new @imperialcollege study reports https://t.co/x8XcnDYH6a https://t.co/5YYzJ6tVtc
2021-12-17 04:14:58 @greg5green @kevinchawkins @OurWorldInData https://t.co/CJqyIZFV62
2021-12-17 03:41:09 @saletan Not at the country level, Will, just Gauteng, via @jburnmurdoch https://t.co/iLKAo0vOfo
2021-12-17 02:48:45 Fortunately, to date, the hospital admissions and fatalities are uncoupled from the very high case numbers and have remained low. This is most likely related to the immunity walls built in these countries, along with the lag time to fully manifest /2 https://t.co/nyczTzFmzq
2021-12-17 02:48:44 The 4 countries with the highest documented Omicron burden have each exceeded their pandemic record for new cases, and still ascending rapidly /1 @OurWorldInData https://t.co/0ifYFGAKII
2021-12-17 02:32:42 @NewsHour @WmBrangham For more on Omicron with @WmBrangham @NewsHour Here's the full conversation we had https://t.co/KAfScwKn9p
2021-12-17 00:17:47 RT @NewsHour: "We have no evidence that the virus itself is more mild," @EricTopol says of the omicron COVID-19 variant. He tells @WmBrang…
2021-12-16 23:56:26 Another O sign, New York City, via @MarkLevineNYC https://t.co/lQvDbGneL7
2021-12-16 23:54:33 "The breakthrough in protein folding is one of the greatest ever in terms of both the scientific achievement and the enabling of future research."--@hholdenthorp @ScienceMagazine https://t.co/pmnvidBzq4
2021-12-16 23:45:18 Last January, the state of Rhode Island had the highest new case/capita of any state or country in the world. Now it has the O-sign | https://t.co/qO9hvfFX74
2021-12-16 23:14:22 What New York City is doing now is what the US should have done for all Americans a long time ago: free KN95 masks and rapid antigen tests https://t.co/xy4NXclgIz
2021-12-16 22:55:10 The Molnupiravir anti-Covid pill randomized trial published @NEJM today. Final results are quite different (half the efficacy) from the highly encouraging interim results https://t.co/3Pvi3iDa8P How does it compare with Paxlovid? https://t.co/qClag5KjUy https://t.co/0W5x5PUMcQ
2021-12-16 21:43:09 The holidays should be a time for getting together with friends and family, but instead we have a double dose of coronavirus strains—Delta and Omicron. How to deal with it? https://t.co/HBNlNeAb0v my oped @LATimes https://t.co/mETILLCmDn
2021-12-16 19:10:25 This is the @ScienceMagazine Breakthrough of the Year 2021 Cover by @oooitsplasma @ScienceVisuals Big congratulations to the 2 groups below with their landmark contributions https://t.co/z3PY7zFEvc https://t.co/bV7psnG1Dw
2021-12-16 18:26:44 RT @JillianHortonMD: Superb piece from @EricTopol in today's @latimes. #Omicron #omicronvariant @KindrachukJason https://t.co/xEGTwSEzjQ
2021-12-16 17:49:35 Exponential growth https://t.co/HlpL4DKTAd
2021-12-16 16:56:10 When another of @nataliexdean's brilliant @twitter explainer + Figure is found in @TheEconomist. This one's on understanding the impact of Omicron https://t.co/lxczLu3H21 https://t.co/WH5B5l441M https://t.co/2IR4Mmss6C
2021-12-16 16:45:47 Up that to 88,376 today https://t.co/pItJxXPpv6 https://t.co/iBjLLbFbw9
2021-12-16 15:24:24 Why is this a unique advance? https://t.co/Bus8FWXN4D
2021-12-16 15:20:15 Summary graph of waning immunity for 4 vaccines over time, during Delta, against infections https://t.co/SDZXFg4Yj2 https://t.co/mCyWtZNxfB
2021-12-16 14:34:34 The anti-Covid pill (Paxlovid) is a veritable breakthrough. Just when we really need it. I wrote about it @SubstackInc. It's free. Please subscribe to follow https://t.co/qClag5KjUy
2021-12-16 14:17:51 A year ago the first Covid vaccines were given. This @nature graph, adapted from @MaxCRoser @OurWorldinData, puts the speed of that remarkable advance in context, leading to untold lives saved and severe disease prevented https://t.co/ny44pW9RTc https://t.co/FROkz1klVE
2021-12-16 13:11:00 Tell it like it is, @CDCgov https://t.co/sDoDeRJZ7h
2021-12-16 05:28:51 Some great news that we desperately need. An in-depth assessment of the 1st potent and safe anti-Covid pill https://t.co/qClag5KjUy
2021-12-16 02:25:05 RT @thenewsoncnbc: "We're in omicron land now, even with delta. To have full effectiveness, you need three [shots] and omicron is much more…
2021-12-16 01:20:24 @leonidkruglyak Right. Wouldn't want to scare anyone about the harsh reality we are facing in the weeks ahead.......
2021-12-16 01:11:19 For a bit of comic relief, the real and #AI generated top Christmas titles for @bmj_latest https://t.co/Fq9h6JFKbu https://t.co/hk3cvzEofh
2021-12-16 00:58:23 https://t.co/aE7U5Mxgdq
2021-12-16 00:49:30 Everyone's familiar w/ the 5 stages of denial. For the pandemic, the US has invented the 5 denials of warnings (it won't happen here). The 5th warning: alarming Omicron signals from S Africa, UK, Denmark &
2021-12-15 23:41:31 @jenbrea In the accompanying text. Referring to infections, not hospitalizations
2021-12-15 23:30:59 What countries are best protected from Omicron? The countries with both the highest vaccination rate and having that boosted. The calculation for Delta (X-axis) gives credit to prior Covid without vaccination https://t.co/mGRxfcaOl1 https://t.co/DyWlnRzKnq
2021-12-15 22:40:08 @jimcramer Numb. In denial. Again.
2021-12-15 22:32:09 Yes, a universal coronavirus vaccine is urgently needed Today @NEJM. We can and must do this. https://t.co/3vIfwQEQrK Variant-proof, cover all sarbecoviruses ++ https://t.co/aGRJNXlLeT https://t.co/IkTT66ANxj
2021-12-15 22:24:50 Covid vaccines should be digital: no need to purify proteins, inactivate the virus https://t.co/oOIMTOd63Y @ScienceTM https://t.co/50e1b57qTB
2021-12-15 22:00:01 The North American @Novavax vaccine randomized, placebo-controlled trial in ~30,000 participants is published in @NEJM today with 90% efficacy vs symptomatic infections https://t.co/baCQHnQ0Yd (most breakthroughs were Alpha
2021-12-15 21:41:56 @JeremyFarrar @JAMANetworkOpen Yes, thanks Jeremy, so much that could be done but the US isn’t moving forward as it should. Shortening the time for boosting is just one example of so many. Very frustrating, to say the least.
2021-12-15 21:38:35 A new report on Omicron's potency for inhibiting vaccine-induced, infection-induced, and monoclonal Ab (mAb) mediated virus neutralization. Only Sotrovimab was effective as a mAb) https://t.co/xs6BSzu8R8 https://t.co/ZeELwqvNbR
2021-12-15 21:31:40 The full preprint just posted with more data for Omicron's impact on the Moderna vaccine and effect of the 3rd shot (booster) https://t.co/4Q5ZQNMeOV https://t.co/PdGYEkGLQR
2021-12-15 20:00:41 I meant to say "should change" but there's no sign that US 3rd shot policy is changing (yet)
2021-12-15 19:44:40 Another new study shows "decrease in vaccine effectiveness accelerated after month 4 after full vaccination" in US Veterans, age 65+, due to both time of waning and rise of Delta @JAMANetworkOpen https://t.co/6RssoQDkBD US policy to change to boost at 4-5 months instead of >
2021-12-15 17:08:33 Another O sign, in London, via @theosanderson https://t.co/7opsAYvfyB
2021-12-15 16:51:37 New data from 3rd shot Moderna (booster, 50 μg) vs Omicron induces substantial increase in neutralization activity, presented today by @WHCOVIDResponse https://t.co/hbYz7WubBV https://t.co/kNPbrTv8oK
2021-12-15 16:24:03 Today the UK had 78,610 new cases, well above any prior day in the pandemic, representing the combined effect of Delta and Omicron https://t.co/pItJxXPpv6 @OurWorldinData https://t.co/0JBjXaXLW2
2021-12-15 16:01:00 Congratulations to @Tuliodna and @kallmemeg for their extraordinary efforts during the pandemic, named today as @Nature's 10, among 10 people who helped shape science for 2021 https://t.co/fYNOskKV1Z https://t.co/Yd8ukcsxvn
2021-12-15 15:16:32 Omicron’s immune evasiveness across all vaccines and prior Covid infectees, now widely replicated for the marked decline in neutralizing antibodies https://t.co/GKMLBJXf0H
2021-12-15 04:05:50 The O signature is a | @Cornell, graph by @AnilOza16 @cornellsun https://t.co/4CNYCZcQSn
2021-12-15 03:55:02 @tedsan Yes, thanks, with the pretty distinct Omicron | signature https://t.co/xVGJlOG0HB
2021-12-15 02:17:55 The country with the highest cases/capita in the world now is Denmark, with 77% of its population fully vaccinated, 23% boosted, soon to be Omicron dominant. (The US is 61% vaccinated, 15% boosted, avg ~120,000 cases per day, w/ >
2021-12-15 00:09:40 If you get exponential growth, you'd buy this UK projection, and realize what it portends for the US: "If Omicron infections continue to double every 2.5 days, as current estimates suggest, there will be a million people infected this coming Sunday alone." https://t.co/WUhcopH7lp
2021-12-14 20:32:32 We just talked Covid with @ASlavitt, who I consider a version of "Mr Phelps," taking on Mission(s) Impossible for helping the United States with its biggest healthcare challenges. Here's our conversation w/ @cuttingforstone @Medscape https://t.co/Vwn4bA67Ug
2021-12-14 18:53:05 A 4th report documents both Prior Covid or 2-dose Pfizer vaccine provide low level neutralization vs Omicron, resolved by , and nearly all the monoclonal antibodies (except sotrovimab /S309 ) will lack effectiveness https://t.co/7rBifm7KyP https://t.co/eXDMpl7cTs
2021-12-14 18:41:13 A 3rd report today which includes Moderna and J& "Neutralization of Omicron was undetectable in most vaccinated individuals [before boost]." 1-shot J& https://t.co/67AFTS9p9I https://t.co/vTdDUlrVlO
2021-12-14 18:07:39 RT @NightingaleOS: We just launched Nightingale Open Science, a computing platform housing massive new medical imaging datasets for the…
2021-12-14 17:18:34 There is no sign of let up of the Omicron wave in South Africa. Highest test positivity yet and ~24,000 new cases added today https://t.co/fyl8yULrm5 https://t.co/Pn2aJtsfgS
2021-12-14 16:54:56 40%—the proportion of people with #SARSCoV2 confirmed infections who are asymptomatic among nearly 30,000,000 people tested, confirmed + https://t.co/LclSkCnP29 in full agreement with our 2020 @AnnalsofIM report https://t.co/EuvXLge1SY @danieloran @ScrippsRTI https://t.co/ILujjIEiG3
2021-12-14 15:57:01 @Dereklowe Agree. But the underpowered low risk trial showed v consistent decline in hospitalizations. All interventions would be expected to benefit higher risk more. There will be supply limitations. Bkthru infections can be more than "mild." I see eventual utility for this indication
2021-12-14 15:42:56 2 new reports: up to 100-fold increase in neutralization activity vs Omicron after 3rd dose vaccine https://t.co/imiVfD52qX https://t.co/BkYOUoPsZy https://t.co/ssLN1NSAAr
2021-12-14 14:47:25 The bottom line that is worth a few seconds for you to read https://t.co/nOzyaxO9od
2021-12-14 14:47:23 Just published @NatureMedicine The most comprehensive assessment of the rare events of myocarditis, pericarditis, arrhythmias after COVID and AZ, mRNA vaccines https://t.co/0bEdMJSLXg https://t.co/eC5JOx0CmG
2021-12-14 14:28:12 New O spikes will exceed pandemic records for cases in many places throughout the world Graphs by @jburnmurdoch Link above and https://t.co/gxxI8NMvRw https://t.co/KVRm3or6L2
2021-12-14 14:08:47 That's the 2-dose drop down. We still need to know how the booster does vs Omicron for prevention of hospitalization and death, and how long it lasts https://t.co/YbAUnMM1IT @Reuters @winning_alex @WRoelf
2021-12-14 13:40:31 Our covid times by @Ramireztoons https://t.co/sXAM8N93kd
2021-12-14 13:17:20 Graph of Pfizer 3rd shot (booster) vs Omicron symptomatic infection, restoring to 75% protection, significantly less compared to its effect vs Delta (95%) with 95% CI, @UKHSA data, vs unvaccinated https://t.co/SHYXiCbKnx by @hannahkuchler @donatopmancini @mroliverbarnes https://t.co/PHMDZGIgDj
2021-12-14 12:56:27 More on this 5-day pill strategy of 2 150 mg Paxlovid tablets and 1 100 mg ritonavir tablet twice daily https://t.co/9ST6F4URt4 by @carlzimmer @RebeccaDRobbins
2021-12-14 12:50:32 The 70% protection vs severe disease represents a substantial decline from 93% in the Delta wave in same population @Discovery_SA via @miamalan https://t.co/D325bCswp4
2021-12-14 12:41:51 We now have a safe and highly effective anti-Covid pill strategy (combination of nirmatrelvir (Paxlovid) and low dose ritnoavir to add to our defense vs Omicron https://t.co/WBagPdQgtX @matthewherper @statnews
2021-12-14 12:33:31 First data for Omicron on 2-dose Pfizer vaccine effectiveness vs severe disease, report from South Africa: 70% protection among > https://t.co/0kPpQLNPPu also confirms @UKHSA report of 33% effectiveness vs infection by @eweise @kweintraub @USATODAY https://t.co/jPeNH90ZdS
2021-12-14 11:45:00 Very good news this morning Exciting new data on Paxlovid anti-Covid pill from 2 randomized, placebo-controlled clinical trials: high-risk final results and standard (low) risk interim findings, summarized here. See @statnews full coverage by @matthewherper https://t.co/8OOMCjsjEu
2021-12-14 06:00:52 The rapidity with which Omicron is taking hold in Europe "In Norway, health authorities warned that if no countermeasures were taken Omicron could infect up to 300,000 people a day compared with the previous peak of about 1,000 cases." https://t.co/2v0zIAjO6p @rmilneNordic @FT https://t.co/owPtGzWgMK
2021-12-14 04:34:57 @davidjlynch Likely equal to 3 shots but we don’t have any data yet to be sure, particularly vs Omicron
2021-12-14 03:45:35 In this column, I present a conceptual model to help explain the apparent reduced severity of Omicron-induced illness to date, emphasizing the T cell layer of defense https://t.co/YWaG8RrgwU
2021-12-14 01:10:46 What Denmark did to cut the booster shot interval to 4.5 months was smart. That's when (~5 months) substantial waning shows up, not 6 months, the US policy, which will leave many not adequately protected vs symptomatic infection https://t.co/uvYigpbtpu
2021-12-14 00:35:30 With so much new data, I've just posted an updated summary for where we stand with Omicron. https://t.co/5NJ1sATKNv @SubstackInc It's called "Ground Truths". It's free to subscribe. It's a 1-month experiment that I'm trying to get deeper into topics than I can via twitter posts
2021-12-13 18:53:35 2 weeks after the @US_FDA advisors narrowly (13-10) voted to recommend Molnupiravir for EUA, it still has not been given a green light, which is telling https://t.co/pzBagKwXkp by @benjmueller https://t.co/PRvdiPOMEO @nature by @maxdkozlov
2021-12-13 15:55:19 Some information on the first 10 patients hospitalized due to Omicron infections, most with 2 vaccinations, age 18-85, 1st death among them https://t.co/mZpzRSGjb8
2021-12-13 15:03:32 The US confirmed Covid deaths exceeds 800,000 Killed 1 of every 100 Americans over age 65 Killed 1 of every 415 Americans. https://t.co/kaFJNo7WVN by @juliebosman @albertsun @amy_harmon ~300,000 deaths well after US vaccine rollout https://t.co/ghdYZmcp0K
2021-12-13 14:19:20 Our covid times :-) by @stephanpastis https://t.co/0kAVsu8fFP
2021-12-12 22:14:29 Hard to watch The US falls further to 67th on the list of countries for fully vaccinated https://t.co/4DfToRXl1g (w/ 2 shot definition) https://t.co/Kg7QuREyZM
2021-12-12 21:48:16 Reinfection from Omicron in people who had Covid —UK "Preliminary analyses indicate approximately 3-8 fold increased risk of reinfection with the Omicron variant" https://t.co/FH0r2hemuF —South Africa > https://t.co/CqGvVSiPub https://t.co/85MqE3pUYC
2021-12-12 21:37:04 If you think Prior Covid protects against Omicron (B.1.1.529), think again https://t.co/B7Lf37DKiq and "Neutralizing antibody titers against Omicron were low, even below the limit of detection in a significant fraction of convalescent individuals https://t.co/I9ECqTzyO8 https://t.co/IfEU24DZAk
2021-12-12 21:22:23 RT @ShaunLintern: The fear of an Omicron wave and trauma of past 2 years is making some staff refuse to be redeployed to Covid wards. The N…
2021-12-12 21:13:05 @Laurie_Garrett Thanks Laurie!
2021-12-12 18:38:30 This is holding up a couple of days later. The longer we go w/ very small % hospitalizations, especially if seen in older people, no prior Covid, unvaccinated, the more likely it'll be the immunity wall + something intrinsic to the virus to explain less virulence (<
2021-12-12 18:24:41 @eliowa @OurWorldInData Because no vaccine manufacturer has submitted data yet to @US_FDA for authorization of boosters for age below 16
2021-12-12 18:15:32 Without a booster vs Omicron, the vaccine effectiveness early point estimate for Pfizer was 35% vs symptomatic infection https://t.co/FH0r2hemuF https://t.co/lgseerlEA6
2021-12-12 18:07:03 The United States lags many countries in uptake of booster shots @OurWorldInData Latest CDC: 26% of eligible and only 51% of people age 65+ have had one https://t.co/COXsuYvtL6
2021-12-12 18:02:49 2 days, that is https://t.co/I7HkZUqOtg
2021-12-12 15:51:26 Denmark, where Omicron is heading towards dominance in a matter of days, on top of its recent Delta surge @OurWorldInData https://t.co/vbI3A6jxlf https://t.co/FuYTwgOlxH
2021-12-12 15:21:54 UK confirmed Omicron cases nearly doubled since yesterday with some leading to the first hospitalizations there https://t.co/HC8C6YfI3y https://t.co/v9vlHOVb9p
2021-12-12 01:56:32 @profheathergray @ScottGottliebMD Thanks for noting. But there are other encouraging reports Today's data, most testing yet https://t.co/uzHrAgfKna Gauteng data plot https://t.co/Hb75ejCG3L
2021-12-12 01:35:37 RT @ScottGottliebMD: The positivity rate in South Africa has been flattening and now declined for the past two days. Hospital admissions in…
2021-12-11 22:02:20 New from @trvrb Extends this pattern to 2 more countries:Germany the the United States https://t.co/Q77Q6yyOQx
2021-12-11 21:15:53 New @MedCellPress Comparative effectiveness of the Pfizer and Moderna vaccines over time, in both the Alpha and Delta US waves, vs symptomatic infections https://t.co/RlWUXeZ2f2 consistent 8-12 % points advantage for Moderna https://t.co/IwHXFIKaEp
2021-12-11 19:32:47 We also don't have data yet for duration of the 3rd shot VE for either variant. Even the early drop in VE after boosters vs Delta (95%) compared with Omicron (75%) would be associated with a potential 5-fold increase in breakthrough infections
2021-12-11 18:58:36 @EpicBear @UKHSA They are in my previous posts. But I presume that would be too difficult to find before you tweet.
2021-12-11 18:43:53 The decline of vaccine effectiveness vs Omicron. Simplified (no 95% CI) summary for Pfizer vaccine vs Delta, + booster, and vs Omicron, + booster (early @UKHSA data) vs symptomatic infection. This is substantially reduced protection. And we have no data yet vs severe Covid https://t.co/xqdpbqZa6e
2021-12-11 17:51:54 The accelerated progress in the science of Omicron over the past 2 weeks, representing remarkable collaboration between genomicists, virologists, immunologists, epidemiologists, and clinicians, throughout the world, is stunning. A preliminary timeline of some of the highlights https://t.co/ldTlgKJ9UX
2021-12-11 17:19:51 RT @EricTopol: Not much has been said of Omicron's potential to induce #LongCovid, but with such high transmission levels that is certainly…
2021-12-11 16:08:46 @Donaldverger https://t.co/xStmHRzwg2
2021-12-11 16:08:07 fixed link https://t.co/xStmHRzwg2
2021-12-11 15:54:41 And the most likely explanation for the lesser severity of Omicron induced-illness that we've seen to date (not the virus, the immunity wall) /3
2021-12-11 15:51:13 You might have missed that in the US yesterday there were 2,100 Delta variant deaths, > https://t.co/0AHQd1HSH2
2021-12-11 15:36:23 Which is why this projection for Omicron in the UK is particularly concerning by @mroliverbarnes @jburnmurdoch @JasmineCC_95 /2 https://t.co/ZcUBMgc2Ti
2021-12-11 15:36:22 The concept of a country/region "immunity wall" vs Covid isn't new. But this analysis by @DevanSinha of the UK's is, showing w/ recent data how extensive it is across age groups https://t.co/qx58EqvwTg /1 https://t.co/Y1Zg4GV3IO
2021-12-11 01:58:32 The quest for the pancoronaavirus vaccine. It's likely within reach. https://t.co/4wGtZW1L4Q by @RobertLangreth @business We've been asking for this to be #1 priority for nearly a year https://t.co/eKHGg7EPtM @nature @DennisRBurton @scrippsresearch https://t.co/aGRJNXlLeT https://t.co/XwSu3CM3bt
2021-12-11 00:06:06 @CzypionkaThomas @FranColombo2019 Yes, thanks. I had addressed that key point earlier https://t.co/82s0EhT8oO
2021-12-10 22:40:29 @StevenSternberg No data, have to extrapolate from AZ, it’s closest cousin
2021-12-10 22:29:10 @KashPrime Nicely done!
2021-12-10 22:25:00 @brianvastag https://t.co/UUaEVTdwlo
2021-12-10 22:15:06 @brianvastag I've emphasized that liability previously (multiple times) and it's a big deal/concern
2021-12-10 22:10:30 There's been a lot of new data for Omicron in the last day, much still preliminary, but here's my summary of the good and bad https://t.co/pL8uiD7hfV
2021-12-10 20:44:16 The similarity/parallel of Omicron rapid growth across 5 countries (logit) https://t.co/CWOrEvQsC8
2021-12-10 18:59:20 Best part of the data on these 581 UK cases: no hospitalizations or deaths to date
2021-12-10 18:50:19 Much more new beyond 1st look at Omicron vaccine effectiveness, summarized in a terrific thread by @kallmemeg https://t.co/k1n8VpyBRw — ~7% cases Omicron reinfections (0.4% Delta) — 3.2X adjusted odds of household transmission (vs Delta) — big growth advantage https://t.co/JrvyjsHQEh
2021-12-10 18:41:33 The 95% CI presented here with relatively small number of Omicron cases overlap vs Delta, but certainly suggest less protection after 3rd dose. For Omicron, essentially no protective effect of 2 AZ doses, 3rd goes to 71% (42,86)
2021-12-10 18:30:46 First data on booster vaccine effectiveness vs Omicron (581 cases): drop in protection vs symptomatic infection by 2 doses (AZ -> https://t.co/FH0r2hemuF @UKHSA https://t.co/tolCOeUOL9 https://t.co/HMNRo9zgR0 https://t.co/F2tYDeyFOy
2021-12-10 17:57:32 @SMImmunology It is indeed accurate. Immune escape and immune evasiveness are not binary terms, it's a continuum and definite that Omicron has this property in excess of any prior variant or the ancestral strain
2021-12-10 16:52:28 How not to prepare D comes before O https://t.co/SGAKlfAHUw
2021-12-10 16:43:17 RT @jburnmurdoch: NEW thread: data show South Africa’s Omicron wave is resulting in less severe disease and death than past waves, though h…
2021-12-10 15:36:56 More supportive data for our T cells to hold up to Omicron https://t.co/GzQpbgvG6O
2021-12-10 14:46:25 @zchagla OK, but that’s sure a lot different than your initial reply to me
2021-12-10 14:25:40 @Antonio_Caramia that's
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2025-01-10 18:54:00 Digitizing the human proteome in >
2025-01-10 18:36:44 Two new reports on T cells and viral infections —more Tregs and enhanced protection via multiple Covid booster shots https://t.co/uM0hjJ8RUg —a vaccine's ability to prevent infections without neutralizing antibodies @NatureMicrobiol https://t.co/l5slObqABj https://t.co/WxM9lrNR1f
2025-01-10 17:54:23 Combining GLP-1 and insulin for Type 1 diabetes: a small randomized trial showed reduced insulin need, less carbohydrate intake, better glucose regulation, and reduced body weight https://t.co/1sdQq5DNmS @NatureMedicine
2025-01-09 18:00:14 @CzypionkaThomas @CellCellPress @ScienceMagazine Good point. I think the answer to your last question is yes.
2025-01-09 17:06:58 New evidence on ultra-processed foods (UPF) from prospective assessment throughout 9 countries in Europe "Higher UPF consumption was associated with greater mortality from circulatory diseases, digestive diseases, and Parkinson’s disease." https://t.co/j4DWTGbhNj https://t.co/OYoSRVjvDE https://t.co/kZWjjnHkEF
2025-01-06 02:51:19 @joybeingfree99 Thank you!
2025-01-05 18:28:39 Mosaic pattern loss of Y chromosome, which occurs in ~40% of men by age 70, is causally linked to heightened risk of many diseases, including cardiovascular, bladder cancer, and Alzheimer's. But it's almost never assessed clinically. A new @NatureRevGenet https://t.co/BUoC3V6h4H https://t.co/QMMlnCoyur https://t.co/7v5IGHRDAo
2025-01-05 17:23:22 In randomized clinical trials, 10 people out of 100 might derive benefit (<
2025-01-05 16:51:54 RT @EricTopol: The scientist who is responsible for driving GLP-1 drugs for the treatment of obesity and testing them for prevention of Alz…
2025-01-05 16:21:38 The world's oldest person died at age 116. https://t.co/9DOnKocHgb Longest human life recorded is Jeanne Calment who died in 1997 at age 122 https://t.co/TdPRVTFmgq
2024-12-31 22:28:49 The severe case in Louisiana (first in US) is not included in these reports https://t.co/w0bXjkGQCC While the risk of human-to-human transmission is still low, the pervasive reservoirs and appearance of new, concerning mutations or those identified as a threat… https://t.co/cEGAdUkRPY https://t.co/2osVdSwXA3
2024-12-31 22:02:26 Links https://t.co/II2O8QSk87 https://t.co/0vuZG39KKa https://t.co/7Rp2vWc6hv
2024-12-31 22:00:20 3. Review of 46 cases of mild H5N1 illness by CDC in 2024 https://t.co/8iGCcmI2bF
2024-12-31 22:00:19 2. Report of the 13-year-old Canadian girl who developed acute respiratory failure. Sequence of her H5N1 revealed 3 mutations that may be linked to higher virulence and adaptation to human cell binding https://t.co/vawzzo39Kb
2024-12-31 22:00:18 Three new @NEJM reports on #H5N1 today 1. An overview by @MichaelGIsonMD and @DrJeanneM "urgent need for vigilant surveillance of emerging mutations and assessment of the threat of human-to-human transmission" https://t.co/wr1oy1E5Qk
2024-12-29 20:53:04 Two new articles today on GLP-1 drugs —Less consumption of ultra-processed foods https://t.co/4focHYCqLb —Cost offset by reduced purchase of food https://t.co/PxGOphrxZJ https://t.co/HQhMC07HO3
2024-12-29 20:32:30 @ScienceMagazine A clip from our conversation https://t.co/i29hqWVrLL
2024-12-29 20:31:03 Like the wet dog (or animal) shake @ScienceMagazine https://t.co/ijucQ9v23G https://t.co/qtoiOQKxfo
2024-12-29 19:53:08 Do you know about PIEZO receptors? We're learning more about their expansive role every day. A new podcast (with transcript and full video) with @ardemp , my friend and colleague @scrippsresearch, who discovered these channels In Ground Truths, see my profile for the link.… https://t.co/j30Vp8dhRV https://t.co/RDA9PYtkjs
2024-12-28 19:10:46 On "Face Age" >
2024-12-24 16:09:11 The potential for using continuous glucose sensors and #AI to differentiate types of glucose dysregulation in people with Type 2 diabetes or pre-diabetes https://t.co/wHk2CtLdmL @NatBME @Snyder_Lab_SU
2024-12-24 15:24:08 Covid is associated with an increased risk of Type 2 diabetes https://t.co/RoxbXcgLDV (one of many reports) But the mechanism is unclear. A new study suggests islet microvascular dysfunction is a contributing factor https://t.co/zZIUIlVDoI open-access https://t.co/gt8hWTH7w8
2024-12-24 15:02:21 A.I. as unlocking life’s deepest secrets and establishing a powerful new basis for curing ills, improving health and lengthening lives. "Once we decipher and truly understand the language of life, it will be magical."—@pushmeet
2024-12-24 14:57:29 The upside of #AI hallucination gift link https://t.co/zYRPhWoz4u by @WilliamJBroad @NYTScience https://t.co/as0FPu7zo6
2024-12-23 22:31:47 Anticoagulation for severe (hospitalized) Covid, a prospective, systematic review https://t.co/CL6qtTqqCC Supports therapeutic levels (vs prophylactic) to improve survival but lots of nuances @AnnalsofIM https://t.co/GUK5ZLRydP
2024-12-23 18:58:20 Good summary of this important advance in a 25-year-old woman with Type 1 diabetes ->
2024-12-23 16:15:40 The potential role of dark microglia, a distinct subset of the primary immune cells in the brain, in Alzheimer's disease @NeuroCellPress https://t.co/FgBZLwCaL5 https://t.co/nNi8pWyyMz https://t.co/p9XjEhBA7k
2024-12-23 15:37:35 Spatial omics of human arteries to understand what drives atherosclerosis: highlights role of the microvasculature (vasa vasorum), adventitial inflammation, migration of vascular smooth muscle cells (and more) https://t.co/rFQROipzPe @NatureCVR @sikandhayat @rkramann https://t.co/LAoAMHOE9F
2024-12-21 16:57:42 Podcast https://t.co/GceTYjOl7H Video https://t.co/HerGUDD7jj https://t.co/8R2NYQzFxm
2024-12-21 16:57:41 Covered in our conversation https://t.co/NADSGONEF2
2024-12-21 16:57:40 Two outstanding front page @nytimes articles on PBMs https://t.co/zfsE6JFI48 https://t.co/zfsE6JFI48 @ReedAbelson @RebeccaDRobbins https://t.co/0kMuyNJUMo
2024-12-21 16:57:39 The 3 big PBMs owned by insurance companies, each with a group purchasing organization, control 80% of US prescriptions https://t.co/83LlnqORPT
2024-12-21 16:38:52 @AwhatsN @AdvancedTweaker exactly. Thanks
2024-12-19 19:33:30 Fixed links https://t.co/dt63FmOICn https://t.co/uQbVTd4ker
2024-12-19 19:28:46 good metaphor to explain opening up extra registers at the coffee shop during rush hour https://t.co/ACJOBhdTOF
2024-12-19 19:28:45 How to improve memory and cognitive function in aged mice Fix the mitochondrial EC (excitation-coupling) @ScienceMagazine https://t.co/DDQkPiDsYP representing a new potential path for replenishing neuronal energy reserves to counter brain aging https://t.co/7N7PsuScAN
2024-12-19 13:59:24 Complementing other biological clocks (epigenetic, proteomic) metabolomics helps predict health and lifespan. From 168 metabolites in >
2024-12-19 13:22:02 Related: The vagus nerve's prominent role in brain-gut, brain-immune system, brain-body interactions https://t.co/4NTWiUmYr1 @sciam @jenapincott open-access https://t.co/h1ETImNMG2
2024-12-17 16:17:23 "Why does the brain need billions of neurons to process 10 bits/second? Why can we only think about one thing at a time?" by @jieyusz and @mameister4 @Caltech @NeuroCellPress https://t.co/5QMHIXoX4H https://t.co/7CtNlXCPZE
2024-12-17 15:55:28 A foundation #AI model for interpreting electrocardiograms across ancestries https://t.co/7BbwuQUDDE https://t.co/0cMN4uGB0i
2024-12-17 15:30:54 A neurologist with 2 APOE4 copies tells us about his experience with #Alzheimers disease https://t.co/RBnOHgKjrE https://t.co/bm3Ac7PCvA
2024-12-17 15:25:48 Unsupervised deep learning of gene expression patterns across 18 types of cancer reveals insights on immune pathways and clinical outcomes https://t.co/eBEXDfFqoX @natBME @suinleelab
2024-12-15 21:45:08 @DocBorelli Yes. On Amazon for preorder
2024-12-15 21:44:43 @greenbranch @simonschuster and great!
2024-12-15 21:43:18 @SeigoIzumo Yes, I am doing the audio version (finally) of this book. Thanks, Segio
2024-12-15 18:04:07 @lightseeker22 Exactly!
2024-12-15 17:33:47 @haydentiff Thanks! Reduction in MCHC setpoint, less progression to Type 2 diabetes and MCHC percentile associated with major cardiovascular events (MACE) https://t.co/3lB4P9Emdd
2024-12-13 18:13:09 And this one, Rhynchophorus ferrugineus, the pugilist! https://t.co/8Z6X0709R1 https://t.co/xnerKmFbVb
2024-12-13 18:08:51 From Nature's top 2024 photos https://t.co/joGaE7oiBU I like this one, standing on the shoulders of giants
2024-12-13 00:23:37 @DocJeffD @PCORI They said there wasn’t enough proof (prelim data) that they’d work!
2024-12-12 19:51:28 The fate of T cells, such as seen in exhausted T cells, is tied to nutrients. This introduces the potential of therapies directed at keeping T cell identity and function intact. (And the infamous Krebs cycle makes a comeback to my brain) https://t.co/6Dv1Cbqxg2 @ScienceMagazine… https://t.co/Vueqa0bNzY
2024-12-12 19:17:34 The capability for producing "mirror life" is out there and poses danger. When some scientists who worked on this became aware, they stopped pursuing it, and co-authored this piece, along with over 30 leading scientists—a @ScienceMagazine policy forum that lays out the risks… https://t.co/aW82Fwz8qH https://t.co/T53bIzbRYh
2024-12-12 01:03:40 RT @EricTopol: New @nature Our blood tests are interpreted by average reference values. That's missing a lot or rich information! Each per…
2024-12-11 22:56:57 Wouldn't have guessed that a PCSK9 blocker (used for LDL cholesterol lowering) might someday be indicated to prevent breast cancer in individuals with a common genomic variant https://t.co/Vxc2oIhNgL https://t.co/ctWzxK623r
2024-12-11 19:44:20 Predicting clotting events in 49 of 53 people with Covid. An immunosensor that rapidly detects 4 different protein biomarkers https://t.co/kSuYo7qk7z @ScienceAdvances https://t.co/ksHpBpKNZj
2024-12-11 18:54:19 Whenand vomit make the cover
2024-12-09 22:26:10 With more layers of data, our ability to predict a person's risk of heart disease is getting better and better https://t.co/BI0ltvTodY @AnnalsofIM adding in social determinants of health, lifestyle, and other data @iftikhar_kullo @uk_biobank https://t.co/ng3i7nWCDY
2024-12-09 20:56:11 RT @EricTopol: We're learning how to control the immune response, like a rheostat, even in the brain. Implications for understanding the ba…
2024-12-09 16:49:34 Huji Xu recognized by @Nature as a top 10 who shaped science in 2024 Off-the-shelf CAR-T cells (CD-19 directed) for treating severe refractory autoimmune diseases. https://t.co/ybMsMmfbJ5 https://t.co/nivCFJpkCi
2024-12-09 16:00:11 Link to paper https://t.co/1WVgBiPAAK This is part of the high-throughput proteomics revolution with #AI analytics that is yielding new insights about the aging process, organ clocks, and much more I wrote about it @ScienceMagazine https://t.co/LGkHiPR4Rt
2024-12-09 16:00:10 2. The protein brevican (BCAN) was strongly associated with brain age gap, MRI structural changes, dementia (all-cause, ACD, and Alzheimer's AD), stroke and movement functions, and Mendelian randomization supported causality https://t.co/7YID4p9y9w https://t.co/E2KkI67Ld4
2024-12-07 15:04:12 The David Sinclair anti-aging companies story, front page WSJ https://t.co/xevWnbXbgp "Follow scientists who say Sinclair tends to exaggerate the findings and implications of age-related research, tarnishing a nascent field vying for credibility" https://t.co/MUba9ispDC
2024-12-06 16:06:30 RT @TwistBioscience: “Are we now entering an exponential phase of digital biology, a vertical takeoff, a golden age of discovery?” -@EricTo…
2024-12-06 15:42:27 Should we intensify efforts to convert some of our white adipose tissue to brown fat? https://t.co/ONJy4NWIti @Cell_Metabolism https://t.co/mxUsmgQHJQ
2024-12-06 15:34:00 The XEC variant continues to show growth advantage in the latest US genomic SARS-CoV-2 surveillance, accounting for 44% of new cases https://t.co/jjl2AnOYb5 https://t.co/aqW4ni4m3p
2024-12-06 14:24:29 From an outstanding review of sepsis in this week's @NEJM https://t.co/6uW3iYAlBe @nualameyer https://t.co/4rsCcoVX2r
2024-12-05 23:52:27 The call to action, by @IHME_UW https://t.co/wKm9rwlSyN
2024-12-05 23:33:48 Forecast of US life expectancy to 2050 vs >
2024-12-05 21:31:29 Fixed links https://t.co/SpoZ5bLtjx https://t.co/xpnqtzFyhv
2024-12-05 21:30:53 @taracdennehy https://t.co/xpnqtzFyhv
2024-12-05 20:55:36 Quite an innovation! Continuous real-time monitoring of inflammation and protein biomarkers in the body with a shaking sensor https://t.co/oHaPVWwQfI @ScienceMagazine @HZargartalebi @NorthwesternU @czbiohub https://t.co/xjYEIvx2yo
2024-12-03 01:23:34 @RendAlKhalili Very kind of you!
2024-12-03 01:22:11 @drfeifei @theworldlabs Congratulations on this rapid and formidable progress, Fei-Fei and @theworldlabs team!
2024-12-03 01:02:57 @sdorodgar Thanks very much
2024-12-02 21:50:57 "Ketone bodies are janitors of damaged proteins, chaperoning away molecular waste so organisms can operate at peak molecular fitness." as demonstrated in multiple experimental Alzheimer's and aging models https://t.co/qxRwiI9KSO @BuckInstitute
2024-12-02 20:47:25 Strong new evidence for T cell exhaustion in myalgic encephalomyelitis (ME/CFS) reflecting chronic viral infection, relevant to #LongCovid, and possible path to treatment candidates https://t.co/HmcYbINPuR @PNASNews https://t.co/gHOFyLfAg9
2024-11-30 23:40:30 RT @EricTopol: A vertical takeoff of life science with #AI LLLMs. Publication of 10 new foundation models of Proteins, DNA, RNA, methylatio…
2024-11-30 22:36:27 @longcovidRD1980 @KevinH_PhD @NIH https://t.co/YllXW9IAcM
2024-11-30 20:46:40 What should we eat? Or avoid? The new Ground Truths podcast is with Kevin Hall (@KevinH_PhD), a leading scientist in nutrition and metabolism @NIH Transcript with links to his many recent publications. Open-access, free, no ads. Link is in the photo below and in my profile. https://t.co/0J5Cy5LU6S
2024-11-30 19:45:18 With all the revisionist history, this early 2021 debate seems relevant https://t.co/SfES1Dzt2F
2024-11-30 14:53:05 PIEZO ion channels are to human physiology as GLP-1 drugs are to treating many diseases https://t.co/OsLKveLhpY @ScienceMagazine
2024-11-28 21:33:13 RT @AI_4_Healthcare: If you only read one #AInHealthcare post-article-link this week, @EricTopol has written your script and the dispensing…
2024-11-28 20:49:44 I stand by my posts on this topic from over a year ago (now 4+ years instead of 3+). https://t.co/ZwR5TRorLT
2024-11-28 20:40:24 Add another today @ScienceMagazine on demyelination https://t.co/3u1ZvVcN0V https://t.co/OOu1A7u9Kh
2024-11-28 20:31:31 Full text https://t.co/rzIyZogEGu
2024-11-28 20:29:16 Blood vessel wall (endothelial) inflammation as a key to multi-organ complications of Covid and #LongCovid @ScienceMagazine w/ @ScienceVisuals https://t.co/I316bJ1D0I https://t.co/0t7SKWmzCN
2024-11-26 21:20:16 A weak article @TheEconomist on the dangers of ultra-processed foods. The subtitle is "a mystery is finally being solved" yet there is nothing in the piece that advances our knowledge...just that they're working on it! https://t.co/qIB2IHMqU4 https://t.co/bpMaYxEr1k https://t.co/5444Mf8pLB
2024-11-26 20:21:34 Then (2020) and Now https://t.co/BAhebkQ1HA @ScienceMagazine https://t.co/AxK3th0x9z https://t.co/WPsSm35QSG
2024-11-26 14:24:34 The hospital-at-home movement is in its early days. Lots of potential using multimodal #AI remote monitoring and validation via randomized trials https://t.co/zTwIdaAs0b by @FenitN w/ @JayPandit https://t.co/7twOSjpErE https://t.co/bPXH8EN2gW
2024-11-25 23:57:43 RT @BoWang87: This is amazing article! Thanks @EricTopol for highlighting two of our new foundation models for DNA methylation!
2024-11-25 22:07:25 The journal @Nature asked 6 biomedical scientists to briefly comment on what should be a U.S. priority going forward. Here's mine https://t.co/zS5oUbb1Be https://t.co/N3A1k1RTaM
2024-11-23 19:00:28 RT @GoogleDeepMind: How can AI revolutionize the scientific method to bring in a new age of discovery? @EricTopol chaired a fascinating di…
2024-11-23 15:31:57 How well do vaccines protect vs #LongCovid, a systematic review during the Omicron era? —about 20% reduced by primary series (vs no vaccination), and —another 20% reduction by boosters vs primary series https://t.co/FMk4Z4W3cP https://t.co/Pq8fb3GZpQ
2024-11-23 14:54:43 Misdiagnosis The author underwent a cardiac CT scan showing a very high score for calcium and was assigned the diagnosis of coronary artery disease. But it turned out he had sitostoleremia, a rare genetic disease, with a very different management plan https://t.co/s95XWSVV8W https://t.co/iA0SyDTvre
2024-11-22 23:27:22 Summary on the XEC variant today @JAMA_current https://t.co/ny739nvo0y
2024-11-22 00:57:26 The power of proteomics Predicting cardiovascular outcomes https://t.co/1lS4iHFh9F @pnatarajanmd @McHoniggg @APournamdari @artschuermans @NatureCVR https://t.co/GAGPcG0z5X https://t.co/0HRU8XCLGd
2024-11-22 00:25:57 They're coming fast and furious! Also today @ScienceMagazine add EVOLVEpro, a protein large language model combined with a regression model, for genome editing, antibody binding and more applications for evolving proteins https://t.co/V4BLfkg5lP @omarabudayyeh @jgooten @idmjky… https://t.co/cn9F57zLbX
2024-11-22 00:09:17 Health inequities in the United States keep getting worse. There are 10 Americas as shown below, with stark reduction (widening gaps) of life expectancy https://t.co/dm1Nf8cfBF @TheLancet @IHME_UW https://t.co/lTg0dPGYUU
2024-11-21 21:07:30 RT @pushmeet: It was a pleasure to be part of @GoogleDeepMind’s first-ever AI for Science Forum. A highlight was joining this panel with @E…
2024-11-21 19:23:02 There's really no such thing as "blue zones" for longevity https://t.co/XhKfoKuAIU @NewsfromScience @ScienceMagazine open-access feature by @IgnacioAmigoH
2024-11-19 12:47:31 Definition of the brain circuitry that slows breathing during emotional stress or anxiety @salkinstitute @justsaysinmice @NatureNeuro https://t.co/GDwkGAlNuf
2024-11-19 10:24:28 which would also drive rebound weight gain after GLP-1 drug discontinuation
2024-11-18 18:32:16 In 23 countries, among >
2024-11-18 16:13:24 New @Nature A mechanism for why durable weight loss is so difficult: epigenetic memory of fat cells https://t.co/bfyTkvWS1P @vonMeyenn @laurahinte https://t.co/6NjAP0n366
2024-11-18 13:54:18 There are now 5 reports like this—#AI performing better than physicians + AI—and we don’t have the explanation for why yet (hybrid was supposed to be best) Gift link https://t.co/wS0MH3X21F https://t.co/GB1gQ24DIu
2024-11-17 15:47:53 RT @EricTopol: Time for some laughter medicine With the Glaucomfleckens @DGlaucomflecken @LGlaucomflecken In the new Ground Truths podcast…
2024-11-16 23:59:02 So proud of you, Oussama, for leading this impactful trial, getting the answer to such an important dangling question
2024-11-16 23:52:49 @SolidEvidence Since Election Day -17K here, +17K at Bluesky
2024-11-16 23:23:30 a clip from the conversation https://t.co/L18EXuhe91
2024-11-16 23:21:20 @MaxineMann52216 @NEJM @omwazni yes it does!
2024-11-16 00:42:30 @SolidEvidence Thanks Marc. That’s about right. All since the election. They’re leaving in droves and it’s not bots. I’ll keep posting here (never give up) but will be showing up much more on Substack Ground Truths (notes, analyses, and podcast) and Bluesky
2024-11-15 17:24:21 @EcoSexuality @ScienceMagazine Yes, I am there @erictopol.bsky.social
2024-11-15 16:55:25 RT @JMRothberg: What a week for biology!! Can’t wait to plug #Evo into @james_y_zou #virtuallab. @impossiblevines @ProteinEvo Thanks @…
2024-11-15 15:46:16 RT @EricTopol: How engineered T cells are changing the face of autoimmune diseases via B cell depletion https://t.co/yREY9OSeyY @ScienceMa…
2024-11-15 15:23:05 ChatGPT for DNA good explainer @ScienceMagazine https://t.co/Jv9JlVKDD9
2024-11-14 02:16:23 RT @EricTopol: New @NEJM A whopping (~90%) reduction of progression to Type 2 diabetes with tirzepatide (GLP-1 drug, dual receptor) vs pla…
2024-11-14 02:06:42 Economic burden of #LongCovid in the UK estimated to be >
2024-11-13 22:47:42 In other GLP-1 new publications today —Country-wide Sweden reduced hospitalizations for alcohol or substance abuse with these drugs https://t.co/qUh5HG0NHN @JAMAPsych —Concerns about discontinuation https://t.co/kknT7E5cFl @JAMA_current https://t.co/QOcoAtG6c6
2024-11-13 22:33:26 Case in point: successful treatment vs a fatal childhood brain tumor #DMG #DIPG @Nature today @michelle_monje and colleagues @StanfordMed @StanfordCancer https://t.co/fwi5l97rCM
2024-11-13 22:00:16 New @NEJM A whopping (~90%) reduction of progression to Type 2 diabetes with tirzepatide (GLP-1 drug, dual receptor) vs placebo in a randomized trial of >
2024-11-11 22:23:10 On the increase in alcohol intake that occurred with Covid in the United States https://t.co/UXqvIktjuR @AnnalsofIM @AyyalaDivya @AdamMLeventhal https://t.co/njg0VurZkT
2024-11-11 20:29:07 @ScottyWitte @theNCI @NCIHTAN @CharlesSwanton @cbailey_58 @oriol_pich @mischellab @MariamJHanjani @Nature Have been for more than a year https://t.co/4JZ7Lg24nd
2024-11-11 20:24:28 @theNCI @NCIHTAN Or the rogue, pernicious extrachromosomal DNA (ecDNA) that revs up tumor growth and block immune response, carrying a poor prognosis for patients https://t.co/6lmgNKHbB7 @CharlesSwanton @cbailey_58 @oriol_pich @mischellab @MariamJHanjani @Nature https://t.co/FbBZddomoJ
2024-11-11 19:25:17 RT @CarryLions: @EricTopol @NatureAging @BartolomucciLab Couldn’t have put it better myself! Thank you for the spotlight on our work!
2024-11-11 16:28:35 An experiment that couldn't be done in people (but might be applicable). Mice subjected to chronic social stress had accumulation of senescent cells in their brain, accelerating the brain aging process @NatureAging https://t.co/UfeoPQ1U74 @BartolomucciLab @CarryLions
2024-11-09 20:10:04 RT @_CatintheHat: @diannahaze This is a superb article from @zalaly &
2024-11-09 20:04:47 I'm not giving up. Not letting any political agendas interfere with dissemination of life science and medical stuff via this channel and others. The latter includes Substack, Threads, LinkedIn, Bluesky, and Mastodon.
2024-11-09 15:18:01 For further reading on this topic and #AI, you can download the PDF of this book by @birchlse for free https://t.co/w2D2JKhJVT https://t.co/EpNK2N90fH
2024-11-09 15:09:53 Brain organoids. Signs of sentience? https://t.co/0O3eNBCcYm by @birchlse https://t.co/GRbo9siKZI
2024-11-09 15:09:52 Organoids. A super review of their role in cancer and potential to guide individualized treatment https://t.co/RNiFZ5DLTE open-access @MedCellPress @karolinskainst https://t.co/AKJnDxOjns https://t.co/dfAlde8xL6
2024-11-07 19:41:37 Importance of the liver's vagus nerve for regulating circadian rhythm of food intake https://t.co/FfLowxdUgA @LaurenNWoodie https://t.co/d4vxRIlOmx @noeliamartsanc @davidra17581122 @ScienceMagazine @ScienceVisuals liver-brain axis for potential anti-obesity target https://t.co/Ov3Sy28UFj
2024-11-07 19:24:52 The Covid pandemic suppressed Flu. A new @ScienceMagazine study investigated why https://t.co/e650W6MVcs —nonpharmacologic intervention (masking, physical distancing) —reduced international travel —change in virus lineage dwell times https://t.co/PuUxQHqJw9
2024-11-07 19:13:38 Why does a wet dog shake it off? A mystery solved @ScienceMagazine The PEIZO 2 receptor https://t.co/62DUg93Owp https://t.co/WiMld7kt1b
2024-11-07 17:32:49 How can autoantibodies directed against the same target be both harmful or protective? Very goodby @EliverGhosn, senior author of this unanticipated finding https://t.co/Xcm91zwIq0
2024-11-07 16:42:59 On the definition, concerns, and benefits of open-source #AI models, particularly @Meta https://t.co/IommCdtdp6 https://t.co/YCd2Mj9wxK @Opensourceorg https://t.co/NeHPbKUQJc @TheEconomist
2024-11-05 01:10:34 I just passed my 15-year anniversary on this platform. It has substantially changed over the years, especially during the pandemic and X. Nonetheless, it still provides the most extensive reach to share interesting and important biomedical advances. That’s why I plan to stay… https://t.co/R4AVoCPClo
2024-11-04 18:43:24 RT @EricTopol: Meet Dr. Rachael Bedard, a physician who cares for and stands up for the people who can't stand up for themselves In the new…
2024-11-04 18:26:07 RT @JeremyFarrar: @EricTopol @NatMetabolism @CraigEdBrown @MyUVic Thanks for sharing @EricTopol - Worth linking role of IL-10 in infectious…
2024-11-04 17:05:33 RT @labs_mann: Check out the excellent ’Dawn of spatial medicine’ blog of Eric Topol where he describes our TEN DVP paper from last week.
2024-11-04 16:12:38 A super review of engineered T cells for cancer (CAR T and TILs) https://t.co/tS1NvsT0zl @JAMA_current @BrudnoN @MarcelaMaus @CSHinrichsMD https://t.co/HW7k1MOhWq
2024-11-02 23:59:00 @CatManDid Many thanks!
2024-11-02 17:52:09 Forget about the election this weekend. There's so much exciting stuff going on in life science and medicine right now, not to miss. Free to subscribe, no ads. Ground Truths. https://t.co/YllXW9IAcM https://t.co/TiuB1eFel8
2024-11-02 15:56:36 @AshleySchapitl Thanks for noting!
2024-11-02 15:44:16 @JaneAFlegal Agree! She's a real gem. Thanks for weighing in.
2024-11-02 15:24:21 @CarlynZwaren @himmoderator Thank you!
2024-11-01 00:56:18 The impact of climate change on health @TheLancet https://t.co/j2bTSyLWjJ a 50-page report Reduced healthy life expectancy at birth, increased vulnerability to infections and pandemics, sleep loss, job loss, increased indoor PM 2.5, food insecurity, and a lot more. Open-access.… https://t.co/97w0mx0e1T https://t.co/ZfipEmBNDE
2024-10-31 18:33:23 Two outstanding pieces by @kakape on misinformation, open-access, @ScienceMagazine https://t.co/FD8sQQtQQ0 https://t.co/zuLeK5PWGo
2024-10-31 16:00:43 Before this exciting discovery, a concise summary of what we knew about the brain-immune system protection or "guardians of the mind" https://t.co/7tKslqpbfD @stemcellreports https://t.co/fDmOv8hDzS
2024-10-31 15:52:33 Of ~5 million people with diabetes in a United States cohort, only 4.2% underwent screening for retinopathy over 5 years https://t.co/UcGBa3KClg @JAMAOphth Supposed to be done in 100% to prevent blindness
2024-10-31 15:19:12 A remarkable visionary perspective for the role of #AI agents to promote discovery in life science, laid out by @marinkazitnik and colleagues @CellCellPress https://t.co/xG6yBECZK6 @KempnerInst @HarvardDBMI @broadinstitute https://t.co/bKytAcduLB
2024-10-29 21:21:46 Across 7 countries, the incidence and symptom complex of #LongCovid, based on the new @WHO criteria (10 databases, >
2024-10-29 21:05:26 @BoWang87 Great work!! We need this
2024-10-29 19:46:53 The latest LLLM (large language of life) foundation model, with state-of-the art chronological age estimation, prediction of outcomes, and performance across different datasets and conditions https://t.co/QJGYC6Bj6g
2024-10-29 14:40:25 Identifying new cancer susceptibility and protective gene variants, new mechanisms, using gene-based burden tests https://t.co/9ecAIQrsVM @NatureGenet @erna_valdis @decodegenetics https://t.co/OfkmYvIFNh
2024-10-29 13:49:27 some of the previous reports https://t.co/QKhM9z4WnG https://t.co/bugfFk3wCJ
2024-10-27 21:21:27 RT @rlacombe: Link here: https://t.co/DOX6dAzzkP
2024-10-27 21:21:19 @rlacombe @euanashley Thank you!
2024-10-27 14:48:10 @labs_mann @NatureBiotech @MundAndreas @MPI_Biochem @Nature Link to my post about all of this https://t.co/3FxdGCexBz
2024-10-27 14:46:53 @labs_mann @NatureBiotech @MundAndreas @MPI_Biochem Here's the new @Nature paper, the first time spatial omics was used to save lives https://t.co/lUiEJL0lGI https://t.co/qHnC769NL6
2024-10-27 14:43:55 This breakthrough was an outgrowth of deep visual proteomics, pioneered by @labs_mann, with the main steps graphically outlined below https://t.co/Hwyahov61x @NatureBiotech @MundAndreas @MPI_Biochem https://t.co/diyRaaphB0
2024-10-25 15:10:55 Extreme healthspan and longevity Taking up running at age 100, and then setting world records https://t.co/XaPFrzz7Mg https://t.co/Op9Mc2nk5l https://t.co/ovdo6uwXGr
2024-10-25 14:32:03 Challenging medical dogma: After a stroke from atrial fibrillation, blood thinners should be started early (<
2024-10-25 14:29:07 Reassuring: decades after stem cell transplants, no indication of increase in cancer related gene mutations https://t.co/l0a7fUiPLD @ScienceTM https://t.co/aQJesDzEAd @Nature
2024-10-25 14:01:24 Here's the new CDC #SARSCoV2 genomic surveillance showing the XEC variant's continued rise, now accounting for about 1 in 5 cases in the US https://t.co/kv3jEFibgx https://t.co/vEAxdRnlu1
2024-10-25 00:19:22 RT @EricTopol: A substantial reduction of #Alzheimers disease associated with semaglutide (Ozempic) in >
2024-10-23 21:15:33 Burnout and depression among physicians, a @NEJM review https://t.co/G1tDAyplyk @Srijan_SenMDPhD #MedTwitter https://t.co/jF2oBB18tJ
2024-10-23 18:00:07 Covid booster shots: 2 new studies and an overview stress limitations of shots for inducing mucosal IgA immunity needed to prevent infections, reinforcing the need for nasal spray vaccines https://t.co/8KSPz7S8CQ https://t.co/9Rf5s8TNTd https://t.co/nH60C7T4Vk https://t.co/K8SdyUgsdb
2024-10-23 14:13:19 Systematic review of 51 studies on Covid transmission during airplane flights —sporadic clusters, proximity to cases —masks helpful for mitigation https://t.co/TmBnoib7Jo
2024-10-23 14:06:24 @WSJ + this oped @nytopinion by @maiasz gift link https://t.co/Oz6yoxQxxD https://t.co/JjGePkidwS
2024-10-23 13:28:39 The increased risk of heart disease associated with exposure to arsenic in the water supply at or below the regulatory limit level https://t.co/1zzWUElteN https://t.co/iHzTALuxmo
2024-10-21 21:45:16 A systematic review of 44 randomized trials of #AI assisted colonoscopy shows significantly improved polyp detection rate https://t.co/cj47bRR8kD @AnnalsofIM https://t.co/vgFefG1Iqj
2024-10-21 14:56:54 A discovery of a bacterial derived enzyme that could change the face of many autoimmune diseases that involve IgG auto-antibodies https://t.co/MaYy39C8iG @CellCellPress @EmoryUniversity @RockefellerUniv https://t.co/AtabPUwrtI
2024-10-21 14:18:23 More data from high-throughput proteomics implicating Herpes and other infections for risk of dementia https://t.co/R9MjAVF70Y https://t.co/GjbVX1RxWO https://t.co/iEZitWAYuI https://t.co/gYE8mNG6r8
2024-10-21 13:51:20 link https://t.co/yN9W15mnwd
2024-10-20 23:48:24 RT @AkassoglouLab: It was such a great pleasure discussing our research with @EricTopol in the Ground Truths podcast! Thank you for highlig…
2024-10-19 17:00:50 An elegant @Nature study by @AkassoglouLab has illuminated our understanding of the role of fibrin (component of blood clots), #SARSCoV2, and brain inflammation in Covid and #LongCovid. This discovery and more in the new Ground Truths podcast, with transcript, key figures (such… https://t.co/lrm8HPvAoV https://t.co/tSHtoIt8u0
2024-10-18 15:48:49 Mapping cancer resistance functional gene variants by #CRISPR genome editing, enabling effective alternative treatments https://t.co/A3h3h7aCr8 @NatureGenet @MatthewACoelho @Garnettlab @sangerinstitute https://t.co/s01FQaVqDX
2024-10-18 15:29:20 The GLP-1 drugs we've got now are just the beginning. The gut nutrient cell sensors ( a cellular instead of a peptide hormone target) have considerable potential. Brief thread by @HansClevers on their new @ScienceMagazine paper https://t.co/fIgAMBWvrJ
2024-10-18 14:37:22 Why intermittent consumption of a high-fat diet may be bad for you
2024-10-18 14:04:26 RT @NightShiftMD: Bottom line: current vaccines should work.
2024-10-17 22:30:31 @Dogma702 Much appreciated. Will stay on it until we have 'em here
2024-10-17 22:29:58 There's a pressing need to improve the efficiency of accurately detecting antimicrobial resistance. How about generative #AI? https://t.co/YDG5rFhXtF A problem of over-flagging, for now https://t.co/gthjEWO17F
2024-10-17 18:45:43 On demand, in the body, cell-based therapies are in the pipeline https://t.co/7GuBWzV3kY @ScienceMagazine @jrivnay @veiseho https://t.co/JRCH04UrmZ
2024-10-17 18:16:58 RT @EricTopol: The influence of diet on our immune system function is getting increasingly recognized, a feature today @Nature https://t.…
2024-10-17 16:25:22 Coverage at @WSJ gift link https://t.co/mI85wDJA50
2024-10-15 21:53:16 Does an AI/ML model provide more accurate warning of clinical deterioration than older models (logistic regression or point-based) among >
2024-10-15 19:42:10 How important circadian rhythm is for promoting our health: a study of ~89,000 @UK_biobank participants with 13 million hours of light sensors https://t.co/yf84XtD0YL @PNASNews @circadian247 "Minimizing night light, maximizing day light, and keeping regular light–dark patterns… https://t.co/x26nl3AXjz https://t.co/yFuDvEh5Gy
2024-10-15 18:32:51 Loosening restrictive access to GLP-1 drugs could save over 40,000 American lives per year https://t.co/azmqiA6rxm @PNASNews @abhiganit @Alison_Galvan @YaleSPH https://t.co/eQK5rZDDmi
2024-10-15 18:24:36 The potential for cell therapies is exploding, well beyond cancer and autoimmune diseases. Here's a new review for neurologic disorders @NatureMedicine https://t.co/G63YuH0FnL @CliveSvendsen @CedarsSinai https://t.co/kmaGLuLsSx
2024-10-15 17:27:51 On the first 1,000 #AI medical algorithms ("devices") authorized by @US_FDA https://t.co/CzbPqgHyvu @haiderwarraich @DrCaliff_FDA @JAMA_current https://t.co/oIUGyuIr4p
2024-10-13 23:17:27 RT @EricTopol: This week in key Covid publications and preprints: —Increased risk of major adverse cardiovascular events 3-years out, irres…
2024-10-13 21:06:59 On revolutionizing genome editing https://t.co/3yHtMnkb6D
2024-10-13 18:02:15 A bit of our conversation on the #AI scientist https://t.co/6UmbzFlBlP
2024-10-13 17:01:48 RT @UrnovFyodor: I have learned a lot from @EricTopol and from @pdhsu - I strongly suspect you will as well and thus recommend this convers…
2024-10-13 16:49:48 @mybadauditions @simonschuster Right! If only the publishing industry could move into the 21st century…….
2024-10-11 23:05:00 Our digital times :-) https://t.co/Hag8VxKoxh
2024-10-11 22:50:27 @JPWeiland If only it would stay that way.........but it won't!
2024-10-11 19:46:35 Why is the XEC variant on the move to be next up, when there's little change in its spike protein compared with KP.3.1.1? Its growth advantage appears to be a new path—due to the change in the nucleocapsid protein (case for this cracked by @LongDesertTrain), which is the 1st time… https://t.co/8Ud5AzUiWm https://t.co/G3GkLDlJD8
2024-10-11 19:01:49 Is loneliness a risk factor for #Alzheimer's disease and cognitive impairment? —Yes, association from a meta-analysis of >
2024-10-11 18:46:18 RT @VirusesImmunity: Much-needed data on the genetics of #longCOVID in a new preprint by @23andMeResearch - GWAS of #LongCOVID identified…
2024-10-08 23:12:52 @PeterHotez Much appreciated, Peter. You're the best!
2024-10-08 23:09:30 At the @NobelPrize press conference today, @geoffreyhinton's predictions for #AI's future impact https://t.co/PAr85BO6eJ
2024-10-08 21:47:50 @wendysueswanson @simonschuster Many thanks, Wendy Sue!
2024-10-08 17:23:12 A very thoughtful review and analysis of the interactions between the brain, the aging process, and energy cost/ conservation, by @MitoPsychoBio and colleagues @NatureAging https://t.co/oHbMpwO5ZL https://t.co/vCULSaH8Hz
2024-10-08 16:51:41 @LundinAdvocates @dysclinic Absolutely! She's a gem
2024-10-02 20:12:55 Novel method of LLM #AI for mental health diagnosis: Inputs of a person's speech patterns including variations in rhythm, pitch variability and voice quality that are typically imperceptible to human ears. Gift link https://t.co/SlTy3plM73 https://t.co/oj0ODYe0Wj https://t.co/JsKpTZw4TP
2024-10-02 17:14:35 The association of road traffic noise and risk of atrial fibrillation, a multi-national prospective assessment https://t.co/PjbJ68A5b0
2024-10-02 16:26:56 Mapping the brain of the fruit fly, smaller than the head of a pin, with 140,000 neurons, 50 million synapses. that took 5 years. It wouldn't have been accomplished without citizen scientists and volunteers! @Nature https://t.co/qhvpKtjqJ7 https://t.co/HDYHk2lld6
2024-09-30 21:29:28 In a randomized trial of time-restricted eating for people with metabolic syndrome for 3 months vs standard-of-care, the HbA1c improved 0.10%. Yes, that's zero point 1 per cent. https://t.co/RriB4fZati @AnnalsofIM https://t.co/loV0uyQJ4T
2024-09-30 18:45:15 Importance of carotid artery atherosclerosis progression by ultrasound (carotid plaque burden, cPB) for prediction of all-cause mortality in a prospective study of 5,700 participants without symptoms https://t.co/hf3XIRTCxg cPB was more informative for risk than coronary artery… https://t.co/ljBvtnKb4V https://t.co/0MQfnJ9A0C
2024-09-30 17:48:06 A prospective study of the impact of air pollution in ~175,000 participants newly diagnosed with T2 diabetes with over 8 years follow-up https://t.co/8MlQi0Z1Bz PM 2.5 exposure associated with increased all-cause mortality and multiple adverse outcomes https://t.co/aBBs0Tmjnd
2024-09-30 15:53:10 RT @EricTopol: My piece @ScienceMagazine today What happens when you can assay over 10,000 proteins in the blood, in tens of thousands of…
2024-09-29 18:48:41 The same group @RockefellerUniv, led by @casanova_lab, published this important paper @ScienceMagazine 4 years ago, on the life-threatening implications of pre-existing Type 1 interferon auto-antibodies https://t.co/upmsYwWQyQ Exemplifies the false dichotomy of "immunocompetent"… https://t.co/JQMUIFG62n https://t.co/i7WyU5VMjN
2024-09-29 17:59:33 @EckerleIsabella Along those lines, the authors of this nasal vaccine paper recently published https://t.co/a0b3suXunM showing ~100-fold increase of ability to neutralize various Omicron variants by nasal secretory IgA vs serum IgG or IgA antibodies, again highlighting the importance of mucosal… https://t.co/9bIvZbIbmj https://t.co/yFeglJYdJk
2024-09-29 14:57:19 RT @EckerleIsabella: Great reminder that mucosal immunity rocks! In my view, such vaccines will be the key for the next emerging respirator…
2024-09-29 03:35:38 @jvsetzler True!
2024-09-29 00:11:36 @DontInhaleVirus @VirusesImmunity Agree. Thanks
2024-09-25 22:32:43 RT @EricTopol: Two doses of a Covid nasal vaccine spray led to >
2024-09-25 17:53:40 Despite lack of data or evidence, there's no shortage of people advocating taking rapamycin, who take it themselves. A list from a year ago https://t.co/zfp19sg73f
2024-09-25 17:33:26 "At least 86.2% participants who completed 2 [nasal vaccine] doses maintained uninfected status, likely without even asymptomatic infection, for at least 3 months."
2024-09-25 15:17:54 The GLP-1 drugs are the most important drug class breakthrough in medical history. We're still learning how they have such broad impact, especially about their anti-inflammatory effects, systemically and in the brain https://t.co/8HagDdLsj7 A new feature @Nature, by @marilenharo https://t.co/ocofHjs28e https://t.co/WWoZyAtUYV
2024-09-25 15:07:40 More unanticipated capabilities of machine (digital) eyes....... The 12-lead ECG prediction of heart blood flow https://t.co/nonxbYY1UY @CellRepMed @fares_alahdab @almallahmo @JiaWu_PhD https://t.co/KZRWDTBy1H
2024-09-24 01:54:56 @loafnw @random_walker @sayashk @Princeton Much appreciated!
2024-09-24 00:51:00 This book —AI Snake Oil—is being published tomorrow, by @random_walker and @sayashk of @Princeton. We discussed it on the new Ground Truths podcast. With transcript and external links to relevant papers. Link in my profile https://t.co/vw4SDQ7fbO
2024-09-23 19:57:05 @casanova_lab Important advance. Congrats!
2024-09-23 19:31:31 About 10% of people who develop severe Covid have autoantibodies to Type 1 interferon, which doesn't get diagnosed. Now there's a simple assay. It's also relevant for other life-threatening viral illnesses, and these Abs exist in ~100 million people worldwide.… https://t.co/zn8qPOo7o0 https://t.co/MDyGyI363A
2024-09-23 15:18:52 One-third of former professional football players (N~2,000) perceived they are affected by chronic traumatic encephalopathy (CTE) https://t.co/teBC8mF0kL @JAMANeuro
2024-09-21 14:58:56 @LongDesertTrain @shannonosaka Couldn't agree more!
2024-09-21 14:48:43 Add the forever chemicals, PFAS ingested from plastic food packaging https://t.co/kbDCbKk2BU by @shannonosaka https://t.co/qEs09qayDe
2024-09-21 14:34:59 We're entrenched in a culture of [blood] cultures for diagnosis of sepsis https://t.co/IAkPYE3keX @TheLancet @UKAMREnvoy @mtosterholm @RickABright Yup. I wrote about this a couple of years ago at Ground Truths and nothing has changed (link in profile) https://t.co/rx6AQ04d5r
2024-09-21 14:23:16 A new, super review on antimicrobial resistance, especially emerging approaches and #AI https://t.co/cQgOHb0RTe @LancetMicrobe https://t.co/d6f3N5OAte
2024-09-21 14:17:20 Fixed link: https://t.co/HnfWPgZSRT
2024-09-19 02:38:27 @SolidEvidence @LongDesertTrain You both may well be right. Watching this with keen interest.
2024-09-18 22:48:49 The increasing global burden of stroke, despite~80% considered preventable, with air pollution now on par with smoking as a risk factor https://t.co/2iBGuhD3um @TheLancetNeuro https://t.co/sQV6t4Tj1G
2024-09-18 18:26:13 Young children (<
2024-09-18 17:45:02 A new finding that drives obesity and metabolic syndrome in the brain's arcuate nucleus of the hypothalamus, a disorder of extracellular matrix, which could be a target of therapy in the future https://t.co/AnCgr329nd @Nature https://t.co/uKQj0wny16 @NatureNV @justsaysinmice… https://t.co/4dgh8u8vvD https://t.co/X6CSadmoUl
2024-09-18 13:43:50 Today in #Alzheimer's disease —pTau-181 prediction in the real world https://t.co/mpDgTUpqo2 —Synergism of amyloid-β and Tau in asymptomatic phase https://t.co/6Mpjbp89my —the microRNAome biomarkers https://t.co/ieebZgRgM4 https://t.co/ewWuZQmQEK
2024-09-17 00:09:09 Bacterial antimicrobial resistance, which is steadily increasing, looms as a major threat. This new @IHME_UW report @TheLancet comprehensively reviews the past 3 decades and forecasts out to 2050. https://t.co/7fI3VOgY7Q open-access Much more needs to be done to avert tens of… https://t.co/QuVsfiqMBM https://t.co/Ex0pYtKaJt
2024-09-16 21:09:39 Here's an excellent review on the topic https://t.co/NxPViZuIZq And the @sxsw documentary that warned about it https://t.co/rV0H88MSaH https://t.co/CwnJU1qw3s
2024-09-16 20:52:31 Social determinants of health (SDoH) greatly affect risk of disease and outcomes, but they are usually not (or very incompletely) assessed in patients. Now LLM #AI is showing potential to help do that from clinical text https://t.co/CI7DHPAaDr @PNASNews https://t.co/ra6lhghhVH
2024-09-16 19:36:57 New immunology insights for #LongCovid Key #SARSCoV2-specific T cell receptor signatures maintained to 2 years compared with unaffected control participants @PNASNews @louiserowntree @TheDohertyInst @kedzierskalab @ProfPCDoherty https://t.co/4dDoe4Ftx4 https://t.co/2Hr6O7qTUU
2024-09-15 00:41:23 @iamzeeeggman They are all good. Novavax has less acute side effects.
2024-09-15 00:10:40 At this juncture, the XEC variant appears to be the most likely one to get legs next. Its current status nicely tracked by @Mike_Honey_ 's thread https://t.co/4AnLa3MXfz
2024-09-14 16:07:36 A sobering independent report on the current status of @NHS in England https://t.co/5TmQ1ppWju by @_StephenCastle Report: https://t.co/PllDZEUDgD Summary by @Carnall_Farrar When I was involved with the NHS review 2018-2019, it was in far better shape https://t.co/uQJCCfe5ns https://t.co/t61vH2eReq
2024-09-14 15:38:36 This week's @TheLancet editorial, a hard stance against direct-to-consumer medical testing https://t.co/IfnVNKfXHv https://t.co/fsZZe0mQf2
2024-09-14 15:25:49 Many countries provide guidelines for the public to avoid ultra-processed foods, but not the US. Perhaps, finally, a start here
2024-09-12 23:25:04 High lipoprotein(a) [(Lp(a)] is a genetically determined, important risk factor for cardiovascular disease that should be (but isn't) routinely measured (at least once). There are 5 drugs that look highly effective for markedly lowering levels in clinical trials. This new… https://t.co/wfFVDA4yfM https://t.co/h1DViytOcF
2024-09-12 23:07:19 Digital medical research exemplifies techquity, expanding the reach to people who can not or will not access site-based, conventional clinical efforts Our new @TheLancet essay https://t.co/gkPHFaON5u @julialmv, Vik Kheterpal @ScrippsRTI @scrippsresearch @careevolution https://t.co/srgFLUMDJ3
2024-09-12 22:42:21 More perspective and critique here, @Nature @maxdkozlov https://t.co/c7ubImSzPS —impact on brain aging most prominent of any organ —clearcut suppression of chronic inflammation —but based on only 12 monkeys assigned to treatment —as my previous post, absolutely requires… https://t.co/99SBYEAi3C
2024-09-12 18:00:08 New @ScienceMagazine How to reduce belief in conspiracy theories? Generative #AI !! —Original research showing ~20% decrease, lasting at least 2 months, even among people whose beliefs are entrenched https://t.co/wT3ksgpi93 —Perspective https://t.co/TVzOrJtT4Y —Editorial… https://t.co/01HvcRexLK https://t.co/gz4FxNzQX3
2024-09-12 16:46:27 —The age of the monkeys studied was between 13-16 years, which is equivalent to human age 40-50 years —The dose used was 20 mg/kg, which is on the high end of human dosing —It's an interesting report but there are conflicting data for metformin's effect
2024-09-11 13:43:26 An unsolved mystery, summary of work in progress to understand basis of propensity for metabolic syndrome and cardiovascular disease. Feature @Nature https://t.co/QsmYDhbe4V by @AnilOza16 https://t.co/whMQp2oPKn
2024-09-11 13:32:12 The impact of stress on sperm function, serially assessed in healthy men, noting a delay of 2-3 months for key changes to manifest https://t.co/fPk3S6oBse @NatureComms @neuronickole @TheBaleLab https://t.co/YnkXfzQVla
2024-09-11 12:51:46 THE ROAD TO WISDOM is a remarkably thoughtful and inspirational book out this week by Francis Collins. Our conversation about it and other related, important matters in the new Ground Truths podcast. (Link in profile d/t X-suppression) https://t.co/ZbTL05MMlY https://t.co/dXAowtNWQ6
2024-09-10 13:21:25 Coverage of this report @CNN https://t.co/gEHbtLtfQu by @mnholcombe
2024-09-10 13:21:24 The favorable effect of endurance exercise (>
2024-08-24 03:14:37 @ArleenElizondo @CorsIAQ @PBS Very kind of you
2024-08-23 17:36:19 We discussed his important recent paper on maximal lifespan https://t.co/niWR9w36gR
2024-08-23 16:32:02 A clip from our conversation Full video https://t.co/krzQWcOUja https://t.co/a3R6Xfu0ti
2024-08-23 15:53:09 Epigenetic aging clocks have become a commonly used metric in medical research and are being marketed to consumers. The new Ground Truths with @prof_horvath, who discovered these clocks a decade ago, provides a frank appraisal of their progress, limitations, and promise. With… https://t.co/ZeKHedfrI8 https://t.co/aOPGXOmfCA
2024-08-23 14:43:00 In the era of large language models: "The extensive efforts previously required to standardize and make coding systems and ontologies interoperable for traditional computing are no longer necessary." https://t.co/lUZsgF77kz by @jnkath @DanielTruhn @Dykex6 @IsabellaWies… https://t.co/1619XhjLgl https://t.co/dshSJOodVb
2024-08-19 21:37:49 Nice explainer for these 5 patterns of brain aging and how they can help predict risk @Nature https://t.co/Dg21bLa3xK
2024-08-19 20:52:27 This is a new finding and adds to the Ground Truths conversation with @euanashley link in profile https://t.co/wBCjavALPh
2024-08-19 19:35:32 A correlation between increased cardiorespiratory fitness (V02 max) and protection from brain aging (reflected by less demyelination) https://t.co/s5Rjvs3IEg @PNASNews @MusBouhrara https://t.co/oaw87P8a4X
2024-08-19 18:00:37 Latest wastewater data on the current wave Shows signs of peaking in all regions except Northeast https://t.co/KlD5tDMHOb
2024-08-19 15:05:43 To help address the antimicrobial resistance crisis, there are hundreds of very promising antibiotic candidates found hiding in our microbiome https://t.co/WhBLyI63Vw @CellCellPress @delafuenteupenn https://t.co/Q9RgbncnXQ
2024-08-17 18:34:46 @LongDesertTrain @SystemsVirology @StuartTurville Thanks Ryan. Would be good to solve this mystery
2024-08-17 15:42:57 The number of different ways cancer can hijack our cells is striking. Add this mechanism to the list: recruiting macrophages that suppress our immune response https://t.co/oT1hJAczQ7 @NatureCancer
2024-08-17 14:52:32 A new review on obesity @TheLancet https://t.co/vCJ9Yf82Ay @IldikoLingvay @psumithran1 https://t.co/U3oNw9OzsG
2024-08-17 00:42:45 Here is the main text of the report in case you had any difficulty accessing it https://t.co/QtM2Hn3WbI
2024-08-17 00:25:27 Just published is the KP.3.1.1 characterization by @SystemsVirology, which helps explain why this has become the dominant variant here and throughout many other countries—higher infectivity and more immune evasion than other variants, w/ its S31 deletion playing a key role… https://t.co/wvQDpak8nZ https://t.co/vOXO6TL7o0 https://t.co/KXVMWNkmHY
2024-08-15 23:28:44 Tirzepatide (Mounjaro) achieves more weight loss than Semaglutide (Wegovy), but how do clinical outcomes compared in the real world? https://t.co/Ffu5b4Zl19 Major differences in less Type 2 diabetes, all-cause mortality and cardiovascualar events https://t.co/aNcQJoXnO7
2024-08-15 18:17:33 How sleep resets the brain for new memories Discovery of new type of hippocampus neuron firing called BARRS (barrage of action potentials) that go silent during deep sleep https://t.co/0oKAvhVtef https://t.co/2zDCEAsobB @ScienceMagazine https://t.co/3ZCbNbdGvr
2024-08-15 18:05:45 Just out @ScienceMagazine New insights from #SARSCoV2 structural biology for pan-betacoronavirus antibodies (which could also be factored into developing universal vaccines) https://t.co/SkopcnxvpK https://t.co/CkUDArIfOD
2024-08-15 16:17:42 Good summary of this intriuging study https://t.co/QkeRGlJK9d
2024-08-15 14:45:48 RT @EricTopol: My conversation with @pnatarajanmd on preventing cardiovascular disease is the new Ground Truths podcast —how low to go for…
2024-08-14 01:40:49 @bluestarpr @YouTube Thanks. We’re trying to get @23andMe to make this work again. Sorry for the difficulty
2024-08-14 01:24:25 RT @pnatarajanmd: Great conversation with @EricTopol on the Ground Truths podcast! We covered a lot! @MGHHeartHealth @MGH_RI @broadinstitut…
2024-08-13 23:05:47 Great advice on ? apoB (a snippet) Full video interview @YouTube (link in post) https://t.co/YFnpXdQ7qW
2024-08-13 22:55:50 My conversation with @pnatarajanmd on preventing cardiovascular disease is the new Ground Truths podcast —how low to go for LDL cholesterol? — apoB, Lp(a), polygenic risk score, CHIP, role of inflammation —new RNA drugs [sorry, link is in my profile due to X-suppression] https://t.co/quKclLig8e https://t.co/gDKoSKS3NL
2024-08-13 14:45:25 Creative approaches, all of which are desperately needed, to address the antimicrobial resistance crisis https://t.co/EafBBNyecc @Nature including #AI, harnessing natural products
2024-08-11 14:08:53 "We seem to have memory-holed not just the suffering of Covid-19 but also the initial burst of inspiring if imperfect solidarity it produced"—@dwallacewells https://t.co/oLkFlBLwJb https://t.co/xCGxQXZCrH
2024-08-09 23:17:22 Explainer for the groundbreaking proteomic clock paper @Nature https://t.co/krK3exzit3
2024-08-09 14:28:59 RT @PamBelluck: About 400 million people worldwide have had long Covid, presenting a global economic cost of $1 trillion a year, a new repo…
2024-08-09 13:38:40 A new #LongCovid comprehensive review @NatureMedicine https://t.co/WT5oSq6kfQ by @zalaly @ahandvanish @LisaAMcCorkell @leticiasaurus @swulfie @VirusesImmunity and me This thread by Ziyad takes you through the essential points https://t.co/hFbsn8j3bs https://t.co/p7Wq8EkKRR https://t.co/wpDQNNuxXT
2024-08-09 12:27:57 RT @zalaly: Our review "Long COVID science, research and policy" is out in @NatureMedicine By @zalaly @ahandvanish @LisaAMcCorkell @letic…
2024-08-08 21:14:11 @austinargen @NatureMedicine Easy when it's so exceptional and groundbreaking! I meant what I wrote as a "landmark" contribution Thanks
2024-08-04 19:58:08 RT @EricTopol: Much of dementia—perhaps half—could be prevented or substantially delayed with attention to 14 modifiable risk factors @The…
2024-08-04 18:26:28 RT @EdBelongia: Nice COVID19 summary by @EricTopol. Some key points: Summer wave of KP.3 variant w/ more severe cases. Consider old b…
2024-08-04 16:27:35 Summary Figure from the new review and my previous Ground Truths post on this topic https://t.co/KtGZ7QgDyM
2024-08-04 16:27:34 We keep ignoring CHIP (clonal hematopoiesis of indeterminate potential= mutations in our blood stem cells) even though it is no longer "indeterminate." A key marker for risk of cardiovascular events and blood cancers. It should be routinely assayed in older adults.… https://t.co/gBGMwojZcF https://t.co/86iZ6m2hvR
2024-08-04 14:58:59 Explainer for current US Covid wave and action plan With links to work by @profshanecrotty @SystemsVirology @JPWeiland @VirusesImmunity @trishgreenhalgh @zalaly @BernieSanders @WUSTLmed #LongCovid [Sorry, link is in my profile because it is otherwise X-suppressed] https://t.co/FZA86ZKrUh
2024-08-02 20:55:37 More from this review https://t.co/UrdS9BwvFy
2024-08-02 19:03:24 Here's @JPWeiland's update on the current wave https://t.co/IJVW5fBMxn
2024-08-02 15:56:27 Cool. Congrats @leetothekiefer #OlympicGames No trade necessary, keep 'em both! https://t.co/WnNDwfIyWT https://t.co/5GBUb9URFm
2024-08-02 15:42:07 @loafnw First week of September
2024-08-02 15:21:49 Up to 20% of people with normal LDL cholesterol have a high apoB level, indicative of increased cardiovascular risk https://t.co/63Fca1Yz8X https://t.co/N5A57OElcj
2024-07-24 22:52:50 Which simply adds more to the state-of-the-science review by @trishgreenhalgh and colleagues. https://t.co/b8JC8yNanc
2024-07-24 22:42:14 A randomized trial in over 4,500 participants for surgical masks [2 weeks, public places] vs controls [no masks] found a 30% reduction (3/100 absolute) of respiratory symptoms consistent w/ infections https://t.co/GUGNFvNFXf @Runar_Solberg @bmj_latest https://t.co/IRMAEGWBRQ
2024-07-24 19:41:22 Good explainer by @LizzieGibney https://t.co/T5HquTf2Rs @Nature
2024-07-24 19:09:31 Learning from single-cell RNA-seq of 1.3 million brain cells from 16 individuals with #Alzheimers disease and 32 controls. Potential protective of Reelin and choline intake/supplementation https://t.co/kLVAqj2qnz @manoliskellis @MathysHansruedi @carles_boix @DrLiHueiTsai and… https://t.co/eM1zP6BtUx
2024-07-24 16:05:37 On GenAI model collapse with training sets of excessive #AI-generated content https://t.co/IfO2yH282k https://t.co/5Nxw8yEqmr @iliaishacked @yaringal @OATML_Oxford https://t.co/gGstPt1Uau https://t.co/S8mia2jIH6
2024-07-21 15:13:23 Meanwhile, not enough is being done to get nasal vaccines (to prevent infections) and universal shots (vs all variants) ready, which would get us out of this vicious cycle of waning immunity, new variants, and reliance on shots which don't achieve mucosal immunity 5/5
2024-07-21 15:13:22 But the FDA has tried to force fit Covid into an annual shot like flu, even though all data tells us it doesn't follow an annual pattern. Even the CDC acknowledges this now https://t.co/Jp6c06ahik 3/5
2024-07-21 15:13:21 We've known about KP.3's marked growth advantage since April and could have made the call then to make the new booster. That would have been aligned well with the current wave (available in July) https://t.co/iPNXFDardi 2/5 https://t.co/09Bht8ifQk
2024-07-21 15:13:20 The new boosters (vs. KP.2) should be available the first week of September. It takes ~90 days make them from the FDA decision on June. https://t.co/vWxxNw7FdF But it didn't have to be that way.......1/5
2024-07-19 19:49:58 @EwingT_PhD @ScienceMagazine @DanielJDrucker Thank you!
2024-07-19 19:48:09 RT @JPWeiland: July 19th update: Another substantial increase this week (+26%). Wastewater signal now higher than last summer's peak, and…
2024-07-19 17:25:50 Just in case you thought the virus wasn't still evolving. Mapped by @dfocosi https://t.co/mHeUaaYaW3
2024-07-19 16:17:31 RT @EricTopol: The GLP-1 drugs have favorable actions well beyond weight loss. How? A succinct @ScienceMagazine review by @DanielJDrucker,…
2024-07-19 15:43:55 The relationship between sleep duration and some chronic conditions in ~7,000 @AllofUsResearch participants @NatureMedicine https://t.co/7xfmnraKnV https://t.co/i2huEUj40I
2024-07-11 22:58:26 The Long Haul, a book on #LongCovid by @r_prior, reviewed by @mendenhall_em @TheLancet Appropriately spotlights the extraordinary patient activism "It's really possible they changed the history of medicine"—@zalaly https://t.co/ZhV0rkssWm https://t.co/PRs8kZEpx0
2024-07-11 18:38:28 While progress has been made with genomics and wastewater surveillance, digital is the big miss. My colleague @JayPandit put together a review paper on this topic @NatureBiotech https://t.co/NswHMmwjPl @ScrippsRTI @scrippsresearch @GiorgioQuer https://t.co/bGhFlpBTLH
2024-07-11 18:29:36 On the notably feeble U.S. response to cow flu #H5N1 @ScienceMagazine https://t.co/AgxQdqdRQd https://t.co/mKgBstwaYk by @sciencecohen https://t.co/euncbG1Bzo
2024-07-11 18:14:19 One of the big missed opportunities in the pandemic was more use of digital tracking. A new @ScienceMagazine paper by @ChristoPhraser @LucaFerrettiEvo and colleagues shows its rich, real-time transmission assessment, value beyond contact tracing https://t.co/5huwzB9CPD https://t.co/a5yGA3xex7
2024-07-11 16:18:01 Discovery of a molecular switch basis for lupus (SLE) using #CRISPR screens to unravel the CXCL-13 T cell circuitry @Nature https://t.co/TrRqadQ8ri @CalvinYLaw_ @Deepakarao @jaehyukchoimd @vwacle @NorthwesternMed https://t.co/VMMWbs8DZl
2024-07-06 17:11:14 RT @BJJscientist: “Exercise could be the most powerful medical intervention ever discovered." In @EricTopol's Ground Truths, learn why no…
2024-07-06 13:27:03 Does “one minute of exercise buy you five minutes of extra life”? My conversation with @euanashley on exercise In the new Ground Truths podcast (link in my profile) with transcript https://t.co/p3iINi6DWe
2024-07-06 13:17:47 RT @19joho: Many doctors who misinformed the public from day 1, like @ScottAtlas_IT, claim they were right. Yet, they refuse to accuratel…
2024-07-05 21:02:10 @ReiterLab Thanks. Missed that typo, fixed. Waist-to-height ratio (not weight)
2024-07-05 21:00:37 A group of 29 experts in Europe came to consensus on many aspects of #obesity diagnosis and management —a chronic, progressive disease —focus on abdominal adiposity —use waist-height ratio (>
2024-07-04 20:58:02 @CarlosdelRio7 @ylecun @ashishkjha @Ilibagiza @CarnegieCorp Absolutely! You’re in this group, Carlos
2024-07-04 18:16:44 A major medical milestone late last year was the first #CRISPR genome editing approval (Casgevy) vs sickle cell disease. But it's very complicated and expensive. How about an epigenetic modifier pill with the same target, as seen here @ScienceMagazine? https://t.co/IXhJM8zWfp… https://t.co/hmLZYsTNbj https://t.co/RpS8BVORZr
2024-07-04 18:03:22 The first tumor infiltrating lymphocytes (TILs) were FDA approved to treat refractory cancer (melanoma) this year. In the new issue @ScienceMagazine a rundown and perspective from the pioneer who worked on developing this living drug for >
2024-07-04 15:51:16 RT @EricTopol: Up to 2 years after Covid, persistent virus and T cell activation in multiple tissues, especially high in gut #LongCovid htt…
2024-07-04 15:16:32 @vkola_lab Very impressive!
2024-03-01 00:00:00 CAFIAC FIX
2024-03-11 00:00:00 CAFIAC FIX
2023-05-22 19:20:09 Older people are the big aerosol particle emitters https://t.co/RFBdviRWOS @PNASNews https://t.co/QaE2a6Wx9o
2023-05-22 15:30:50 Another example https://t.co/VueXtAFqgU
2023-05-22 15:28:45 Seeing pain the brain "The development of personalized pain biomarkers will be central to accurate diagnosis, tracking prognosis and for future therapeutic drug and device development." @NatureNeuro @PrasadShirvalka @NeurosurgUCSF https://t.co/l2RTmjRjhY https://t.co/rSzqvKvsF8
2023-05-22 15:26:44 Example https://t.co/JcyvN2AUs2
2023-05-22 15:26:43 @NatureBiotech Continuous wearable ultrasound using #AI to auto-capture body deep tissue imaging and physiology during mobility for up to 12 hours https://t.co/GVZwrLTEkr @JackLin62608901 @XugroupUCSD @JWangnano @UCSDJacobs
2023-05-22 15:09:19 "#SARSCoV2 was detected in aerosol samples up to 52 days after the initial infection." @NatureAging from aerosol monitoring of 3 Belgian nursing home outbreaks https://t.co/Y8xcfk7a1P #COVIDisAirborne @ElsKeyaerts @johanvawe and colleagues
2023-05-22 13:24:19 Our #AI times :-) @speedbumpcomic https://t.co/YVdjg3VQy6
2023-05-22 13:07:16 A biomarker has been validated as an independent and significant risk factor for heart disease and cancer, but isn't being used clinically. Why? https://t.co/notqyijOMH https://t.co/EPtoEwNbSG
2023-05-21 20:26:11 It's time to get serious about CHIP. Step 1-what is it? https://t.co/notqyijOMH https://t.co/bFkmW9DNUo
2023-05-20 19:51:12 More on this, H/T @LawrenceYoung11 https://t.co/OxJf8Ake8B https://t.co/WOG7D135TP
2023-05-20 17:49:11 This is part of the Hospital-at-Home movement, reviewed here https://t.co/W95yJBsFGp
2023-05-20 15:51:22 #MONITORHF trial @HFA_ESC #HeartFailure2023 Presented today by Jasper Brugts, @rudolf_deboer and colleagues https://t.co/xPzNGd5ku3
2023-05-20 15:42:28 @TheLancet A randomized trial in patients with heart failure shows superiority of remote monitoring for prevention of hospitalizations and marked improvement in quality of life metrics compared with standard care https://t.co/HKtWu8VMid @escardio @rudolf_deboe https://t.co/LNGegBNC9F
2023-05-19 23:21:06 @sciencethecat @alanalda Thank you!
2023-05-19 19:00:00 CAFIAC FIX
2023-05-21 19:00:00 CAFIAC FIX
2023-04-21 00:00:01 CAFIAC FIX
2023-04-15 00:10:53 RT @pnatarajanmd: Why do hibernating bears, despite prolonged immobility, not get venous thromboembolism? In a new study, scientists prior…
2023-04-15 00:09:43 @DocJeffD That’s a key point that many people miss. Thanks
2023-04-14 22:46:33 RT @JPWeiland: According to wastewater data from https://t.co/BDwnbGcDaH, US infections are the lowest they've been in over a year. Out of…
2023-04-14 16:19:25 How #AI performance results should be reported, not the way it's done now https://t.co/6XGX0XWure @ScienceMagazine by @DrRyanBurnell and colleagues and https://t.co/pdG03N1bPt @brittanytrang @statnews https://t.co/nPZMxweEMa
2023-04-14 15:11:42 This week there have been 2 important reports that reinforce the bivalent BA.5 booster did better than expected 1. Protection vs BQ.1.1 and XBB.1.5 https://t.co/tBIutN6SVP 2. High effectiveness vs severe Covid in large cohort age 65+ https://t.co/tt54BE3WzI https://t.co/Qfhqrdqrw2
2023-04-14 15:02:11 The XBB.1.16 characterized by @SystemsVirology https://t.co/5yC2vlnp1v
2023-04-14 14:59:09 The XBB.1.16 variant, with a decided growth advantage as seen in India, is starting its overtake to become the dominant one in the United States https://t.co/jjl2AnOYb5 Clinical implications are unclear, but likely not a significant wave here. Still reason to be cautious. https://t.co/LFu2TA3J3i
2023-04-14 14:40:10 How is our gut microbiome transmitted? https://t.co/9HDLp1J2dA @cibiocm @Nature https://t.co/5wd4kJouvg by @Amira_Metwaly @nsegata @NatRevGastroHep Important implications for health and disease https://t.co/dVJmUATl0T
2023-04-13 22:42:52 "This study is one of the first to evaluate real-world effectiveness of the bivalent mRNA vaccine booster to reduce hospitalization or death due to Covid-19." 68% reduction of death https://t.co/2RjM4XpUWY
2023-04-13 22:39:25 A 72% reduction of Covid hospitalizations with the bivalent (BA.5) booster vs not boosted in people age 65+ https://t.co/5Bw8YvZwvm @TheLancetInfDis @ClalitHealth @ClalitResearch @ArbelRonen and colleagues https://t.co/9eo6ES4up3
2023-04-13 17:09:01 It's not (usually) cancer that kills
2023-04-13 16:35:21 On the multitude of ways LLM #AI like #GPT4 can impact healthcare https://t.co/Rp4cjo0RGV @Nature https://t.co/kL3oaMGUwH https://t.co/hdeVeQ34cC
2023-04-13 15:42:26 Nice graphic summary of cancer immunotherapies https://t.co/JjlghpGJdL @CellCellPress https://t.co/m1KJRjbeAi
2023-04-13 14:43:18 Our #AI times by @kaltoons https://t.co/kHTskiYrR8
2023-04-13 14:13:59 Smartphone DIY ultrasound imaging w/ #AI guidance https://t.co/4TOhpA2nXD More in-depth here https://t.co/cqHYQjCziX https://t.co/WeoiC5u1TO
2023-04-13 13:57:44 A T-cell directed vaccine against Covid, with non-spike, conserved antigens (e.g. nucleocapsid, ORF1ab), effective in experimental models for preventing disease, has gone into clinical trials https://t.co/Iahj9pTCzI https://t.co/JbQYGGjd8c @CellCellPress https://t.co/j1wJGVHLNT
2023-04-13 13:36:36 Beyond autoimmunity as a mechanism for #LongCovid, the heightened risk of autoimmune diseases "Compelling and reliable evidence that #SARSCoV2 infection is linked to a substantially increased risk of developing diverse new-onset autoimmune diseases..." https://t.co/QJx7nBcvGe https://t.co/D1qPPNONbL
2023-04-13 00:50:54 If you’re interested in how #AI will reshape healthcare in the large language model era https://t.co/49Z35U2hED
2023-04-12 23:07:50 A significant advance for #Parkinsons disease: the biomarker α-synuclein is an accurate classifier, detects very early (prodromal), and a target for Rx as determined in a large cohort with controls https://t.co/NEQUzefu0n @TheLancetNeuro https://t.co/v7IBfpkgSL
2023-04-12 21:24:06 A tour de force work in clinical genomics: >
2023-04-12 21:03:59 Full text And consistent with prior post in January on the bivalent booster's outperformance https://t.co/tR5S4BBaYb https://t.co/x6Ce1SiLrP
2023-04-12 21:01:00 The bivalent (BA.5) booster protection from Covid hospitalizations and deaths exceeded expectations vs the BQ.1.1 and XBB.1.5 variants https://t.co/0zi9RPBXC0 But VE waning seen
2023-04-12 18:04:48 National Public Radio (@NPR), a leading independent, trusted, non-profit news media organization in the United States that reaches millions of Americans every day, quits @Twitter https://t.co/QRZce75hLm
2023-04-12 17:47:53 RT @GaviSeth: Fascinating read by @EricTopol on the “major triumph” of new #RSV vaccines and why “this is the most exciting time in the his…
2023-04-12 17:45:06 @pnatarajanmd @Nature @AlexBickMDPhD @jaiswalmdphd Great body of work. Why isn't CHIP getting routinely or ever assessed in clinical practice?
2023-04-12 17:40:23 That is why this program is so damn important https://t.co/bCN1afrKt9 https://t.co/nwTGUGa4Jw
2023-04-12 16:59:38 How to prevent Covid infections in multiple experimental models that were not prevented with shots. Sterilizing immunity by a nasal vaccine https://t.co/zfpVQozLJE And a potential 2-fer against flu! https://t.co/g3z3J67TE1
2023-04-12 16:31:58 Nice thread and perspective by @Michael_D_Moor https://t.co/d88GgPuJ2z
2023-04-12 15:18:25 For free access to the @Nature paper https://t.co/Rp4cjo0jRn
2023-04-12 15:14:59 I've summarized some of the key points in a new Ground Truths https://t.co/kL3oaMGUwH
2023-04-12 15:12:42 Our @Nature paper on Foundation models (aka Large Language, Generative #AI, such as #GPT4) for medicine was just published https://t.co/z6eB0l80vY @Michael_D_Moor @pranavrajpurkar @ZahraShakerii @jure @hmkyale
2023-04-12 13:59:32 Our #AI times :-) https://t.co/ODqVL2Y2rp
2023-04-11 22:23:11 RT @CrabbBrendan: I talk about this disconnect a bit in this thread. https://t.co/a4IvkWxGTg
2023-04-11 20:05:35 "We have isolated and characterized 2 human monoclonal antibodies which exhibited neutralizing activities against all #SARSCoV2 variants tested, including BQ.1. and XBB.1.5" https://t.co/jCiQumZgG0 https://t.co/EpQAFemTuW
2023-04-11 17:36:05 As global confirmed Covid deaths reach a new low for the pandemic, excess mortality estimates are on the rise @OurWorldInData https://t.co/SJfbplurOg
2023-04-11 17:18:45 RT @chrischirp: Why or why aren't we investing in cleaner indoor air? It's a no brainer. It would be a no brainer even if covid had never h…
2023-04-11 17:03:20 Important work, nicely summarized by @VirusesImmunity's thread (above) and the paper's concluding paragraph https://t.co/tNgYfMnEIB
2023-04-11 16:24:03 @KenGursky From the @washingtonpost article. I'm quite upbeat we'll have a nasal vaccine to help block infections and this program will get us there faster https://t.co/NNisfRUX8X
2023-04-11 15:47:19 A randomized trial to individualize blood pressure medication for optimal control https://t.co/naNRVwO7IZ @JAMA_current This could be facilitated by automated, 24/7 frequent blood pressures as reviewed here https://t.co/Ek9AtGmET0 https://t.co/yTKoT7g18V
2023-04-11 14:13:58 RT @EricTopol: Should you get a multi-cancer early detection (MCED) blood test? A solid, balanced appraisal of the new "liquid biopsy" 18…
2023-04-11 12:53:46 Immune evasion of #SARSCoV2 is not only via blocking our interferons or neutralizing antibodies. As the virus evolved, suppressing the T cell response now demonstrated. https://t.co/TsZj1ovs4K
2023-04-11 12:46:40 Print version of the announcement in today's paper https://t.co/8wMqq4evM9
2023-04-11 00:39:10 @pknoepfler @AnnalsofIM @BobVolkPhD @glynelwyn Hi Paul, I wrote about it some months back (last section), not much has changed https://t.co/e7Fl0F8BDW Short term ?
2023-04-11 00:17:40 Should you get a multi-cancer early detection (MCED) blood test? A solid, balanced appraisal of the new "liquid biopsy" 18 tests that, in healthy people, can pick up microscopic cancer and w/ #AI determine site of origin https://t.co/pmfXfWLUi5 @AnnalsofIM @BobVolkPhD @glynelwyn https://t.co/zGPa0XTSkp
2023-04-10 23:49:03 This was 2 years ago. We don't need to dream anymore we can do this. https://t.co/bCN1afrKt9 https://t.co/mIgANALAar
2023-04-10 22:05:56 The background and rationale for this important initiative https://t.co/bCN1afrKt9 https://t.co/CrEaqcJkXe
2023-04-10 21:34:34 I wrote about Project Next-Gen—thankfully the United States has gotten serious about new Covid vaccines and treatments. https://t.co/bCN1afrKt9
2023-04-10 20:25:25 This is big, folks. The @WhiteHouse is supporting next generation—nasal and variant-proof Covid vaccines —and therapies with a $5 billion program https://t.co/fMxCJAzIA5 by @ddiamond Thanks to the relentless efforts of @AshishKJha46 and @WHCOVIDResponse
2023-04-10 19:53:28 How to reduce airborne disease transmission during indoor gatherings Besides mask-wearing, "ventilation and break times are critical" in prevention. "Their impact would equal or exceed that of masking and moderate isolation of infected individuals." https://t.co/ePxZTNRZhN https://t.co/wxusx7vSD9
2023-04-10 17:41:16 RT @EricTopol: A double feature Ground Truths in the past 2 days —Automated 24/7 cuff-less blood pressure wristband sensor https://t.co/Ek9…
2023-04-10 15:12:30 A randomized trial of coaching for physicians (N=40
2023-04-09 19:19:46 Chromosomal instability (CIN) "remains one of the greatest unresolved genomic challenges in cancer treatment" and may become druggable .https://t.co/n4XMLBv14I @ScienceMagazine by @Samuel_Bakhoum https://t.co/lV9LfXqDtS
2023-04-09 18:25:54 @CNakas Good to know. Thanks!
2023-04-09 18:18:39 RT @siobhannyc: “This is the most exciting time in the history of vaccines.” Great edition of this very great newsletter!
2023-04-09 17:07:05 RT @sarikaphatak: Non-invasive, cuff-less, continuous blood pressure monitoring bracelet - a holy grail of sensor &
2023-04-09 16:54:48 @BillyWcostigan She didn't have Long Covid
2023-04-09 16:44:09 After a patient saw multiple physicians and neurologists over 6 months and was assigned a diagnosis of #LongCovid, a relative entered her symptoms into #ChatGPT with the correct output. Diagnosis was confirmed by antibody testing and therapy has been initiated. https://t.co/lFfp1zZmRT
2023-04-09 00:45:14 A double feature Ground Truths in the past 2 days —Automated 24/7 cuff-less blood pressure wristband sensor https://t.co/Ek9AtGmET0 —Why the new RSV vaccines are a BFD https://t.co/MJmiy8FFUj https://t.co/yIZnHbUeBL
2023-04-08 20:32:33 @BagaiDr Thanks Sanjeev
2023-04-08 19:35:52 https://t.co/fxvud14CnX
2023-04-08 17:24:27 RT @Daltmann10: Posts Exaggerate Lab Findings About COVID-19’s Impact on Immune System https://t.co/SD3LKVmg2m via @factcheckdotorg
2023-04-08 15:59:10 A very good glossary in the new world of GPT-x #AI https://t.co/MDOFG8iBpB by @Adampasick https://t.co/PoZlAXAZjt
2023-04-08 15:50:00 The free speech of @elonmusk's Twitter, yet again https://t.co/GHlwBcjgdJ by @kateconger @RMac18 https://t.co/gvFGNRDjj9
2023-04-08 14:49:32 Yup. #AI will have a transformative impact on medicine https://t.co/jYWmstBrft by @ISBLeeHood @ISBNathanPrice https://t.co/ekyM3WQswp
2023-04-08 00:53:45 Incredible and pathetic: this is what @twitter puts out in response to my post on substack! https://t.co/5Dnyao4trN https://t.co/VCQwToDwKg
2023-04-08 00:00:58 RT @JPWeiland: I'm honored to have my work featured in @NYMag along with @EricTopol ! Yes, the US is in a decent lul, but it's imperative…
2023-04-07 21:18:49 So Twitter won't allow responses or retweets to a Substack post. "free speech" https://t.co/5Dnyao4trN
2023-04-07 21:00:48 Characterization of the growth advantage of XBB.1.16 compared with XBB, XBB.1.5, with its increased fitness that will likely account for it replacing the current variants https://t.co/5yC2vlnp1v by @SystemsVirology
2023-04-07 20:34:26 @DKThomp I just posted a new @Substackinc and @twitter won't allow responses or retweets! https://t.co/Ek9AtGmET0
2023-04-07 20:31:47 Independent replication of some reduction (~25-30%) of #LongCovid with Paxlovid treatment versus controls, among non-hospitalized, vaccinated people with acute Covid https://t.co/52pBWBYpBt @rushin311 @SarjuGanatraMD and colleagues @LaheyMedicine @LaheyHospital https://t.co/bmMuo3ZAds
2023-04-07 20:19:23 The new Ground Truths is about a continuous BP monitoring bracelet I've been testing https://t.co/Ek9AtGmET0
2023-04-07 15:11:23 Spike protein in the skull-meninges An important niche of the brain immune response as reviewed in this new @ScienceMagazine paper https://t.co/RQ7uxMWQra https://t.co/yfJwjUoiGt
2023-04-07 15:02:15 XBB subvariants are starting to crowd out XBB.1.5 in the US without notable change in clinical outcomes. XBB.1.16 is here and not shown by @CDCgov tally, likely the one to overtake in the weeks ahead https://t.co/jjl2AnOYb5 https://t.co/hdxN6pb4Sm https://t.co/YRSB3jepwW
2023-04-07 14:36:48 Nah by @sdutBreen https://t.co/qdGs3tcc5u
2023-04-07 14:18:48 For a future of everything piece, I spoke to @arianapeca2 about smartphone ultrasound image #AI selfies https://t.co/4TOhpA2nXD https://t.co/gO9Dt5HWc5
2023-04-07 05:54:56 @chrishendel @karlsteinberg @ScienceMagazine @jcouzin Exactly. Thanks
2023-04-06 22:59:29 How Covid is transmitted in households, via a prospective study and dense longitudinal testing (through Alpha variant wave) https://t.co/H9U8YVvgJl @LancetMicrobe Hands and surfaces play a role https://t.co/xxNC1Natwb
2023-04-06 22:08:45 This also relates to the very interesting report of #SARSCoV2 spike protein found in the skull-meninges-brain axis today https://t.co/N2tVLKn37A
2023-04-06 22:07:04 Our understanding of the brain and immune system has radically changed . A new, 5 review @ScienceMagazine today by @castel_giulia @Tommaso_Croese and @WeizmannScience colleagues w/ @ScienceVisuals https://t.co/RQ7uxMWQra https://t.co/k97SYiurRP
2023-04-06 21:24:43 Julia, better than R and Python, for life science? https://t.co/oZNEd7mR9e @NatureMethods by @Roesch_E @theosysbio @jgreener64 @nassarhuda @ChrisRackauckas @adamlmaclean @JuliaHubInc https://t.co/i82bgpMAEN
2023-04-06 20:26:22 I think we can do this without an algorithm https://t.co/wxD0iOZFms https://t.co/eFzq4sRNeq
2023-04-06 18:23:16 Ugh. Honey, I (new Alzheimer drugs) shrunk the brain https://t.co/2LpM15zPRz @ScienceMagazine @jcouzin https://t.co/yd6Qkrk65P
2023-04-06 17:34:27 The potential and a mechanism for diet and probiotics to rev up immunotherapy vs cancer and improve clinical outcomes https://t.co/zvyKyaFDYr @CellCellPress @MeiselLab @MackJBender @AlexCMcPherson https://t.co/crLnjgJkPM
2023-04-06 17:19:58 Spike protein in post-mortem human brain https://t.co/HFlOfy7krf
2023-04-06 16:33:33 A randomized trial of time-restricted eating (w/ intermittent fasting, iTRE) vs calorie restriction or standard care in people at risk for diabetes #T2DM https://t.co/BuyDdOYdJb iTRE best for glucose metabolism @NatureMedicine https://t.co/AoHi0Z0b0K
2023-04-06 15:52:06 Centenarians have a youth-pattern gut microbiome signature https://t.co/nkkSAMdxcV @NatureAging https://t.co/4N39oyrVAo
2023-04-06 15:04:33 The death rate for Covid still markedly exceeds that of flu for hospitalized patients with either virus (6% vs 3.75%), as seen among people age 65+, and higher among unvaccinated, in the @DeptVetAffairs dataset https://t.co/DUNjRkxjp5 https://t.co/CTi7bNKQ6Q
2023-04-06 14:15:54 as shown here https://t.co/lfxHqsy5Wf
2023-04-06 14:00:31 https://t.co/2svEVytLG3
2023-04-06 14:00:30 Important new report on #LongCovid and the brain demonstrating persistence of the virus spike protein, throughout the body and particularly the skull-meninges axis, both in humans and the mouse model https://t.co/tcOywXMafL by @erturklab @zhouyi_rong @HongchengM @Sakethkapoor https://t.co/JqISpqaiLi
2023-04-05 21:22:13 These are major triumphs 66 years later after RSV was 1st reported. It is the/a leading cause of pneumonia in young children and older adults. Accompanying editorial by @ruth_karron https://t.co/q7EVzpTnls See importance of prefusion spike stabilization in Feb 15 thread above https://t.co/7DwqRyUvbs
2023-04-05 21:14:31 "But now with these LLMs like #ChatGPT, you see patients going to and asking questions that they’ve wanted to ask their doctors — because...you forget things when you go to the doctor, perhaps because you’re stressed, and because, unfortunately, doctors don’t have that much time"
2023-04-05 21:09:14 "Having #AI as an assistant to the doctor is going to play to the strength of the doctor as an intellectual, compassionate provider of care....I fully anticipate is going to happen in the next year, year and a half"—@zakkohane https://t.co/wp3YpI0BoA
2023-04-05 21:02:00 New @NEJM today: 2 new randomized trials showing high efficacy and safety for an RSV vaccine in pregnancy (against infant illness) and adults 60+ years of age https://t.co/fAs6UFuEPr https://t.co/F3JJwt8SMO https://t.co/VRNDvqIciH https://t.co/K7TkpcvbDI
2023-04-05 20:36:09 RT @stephaniemlee: Scoop: A peer-reviewed study claimed that as many as 278,000 people have died from COVID vaccines. It went viral in anti…
2023-04-05 19:52:32 RT @SouaidTarek: 1/ Ever wondered how the 4th industrial revolution (#AI, robotics, and big data) is reshaping healthcare? Let's dive i…
2023-04-05 15:40:49 Air pollution and diminished Covid vaccine response https://t.co/7q4Z6cjINF and lung cancer in non-smokers https://t.co/Fb1aMnJyys @Nature https://t.co/w6E30TVFMr
2023-04-05 15:20:37 "#AI-guided assessment of cardiac function in echocardiography was... superior to the initial assessment by the sonographer." Saved time for both sonographers and cardiologists https://t.co/6OBOdfIrxh @Nature @David_Ouyang @bryandhe @james_y_zou @CedarsSinai @StanfordDBDS https://t.co/w1iFM92axJ
2023-04-05 01:27:18 Mask studies, before &
2023-04-04 21:06:11 @inducekarmaaa Maybe you should read the thread before posting......
2023-04-04 19:16:55 Twitter's steady deterioration. As recently documented here by @faizsays and @jeremybmerrill https://t.co/G6835BLBrL It extends well beyond its "For You" timeline https://t.co/ue7YB0VD42
2023-04-04 16:01:35 #GPT4 and #ChatGPT comes to radiology https://t.co/736FIz1rBN "GPT-4 successfully transformed all free-text reports into valid JSON files without error (170/170), which could then be read automatically." https://t.co/JLbBlKXGyi Tested for breast cancer screening advice
2023-04-04 15:44:04 I hadn't heard "King Kong" applied to the new obesity drugs https://t.co/OHFt8X6FMY by @Loftus I reviewed them here https://t.co/SMZO20WGRs https://t.co/2B4BuVk21u
2023-04-04 15:24:02 The weekly US Covid death rate hit a low for the pandemic https://t.co/hdxN6pb4Sm But so many of the ~230 deaths per day are preventable https://t.co/LiUWY65XRC
2023-04-04 14:46:10 In the works: multiple shots on goal for preventing Alzheimer's disease https://t.co/S6uOvC3WAL Feature @Nature by @alison_c_abbott https://t.co/z8FD0ifgcp
2023-04-04 02:06:00 RT @CrabbBrendan: The science keeps moving... Well worth keeping infection/reinfection rates down with existing vax, breathing clean indo…
2023-04-04 00:56:39 It should not be paywalled. Here's the crux of the text https://t.co/NdddNA3EZM
2023-04-04 00:42:48 Finally. @US_FDA approval to make available free 2nd bivalent booster for age 65+ and immunocompromised https://t.co/2D22cuxt9W by @lauriemcginley2 and @bylenasun
2023-04-03 21:55:30 Before we were left with no effective monoclonal antibodies to #SARSCoV2, some real world evidence suggests they were effective in reducing death by 86%, hospitalization by 26%, including immunocompromised people https://t.co/NHDSOz1Xe6 @AnnalsofIM @marroquinoc @UPMC https://t.co/gi0hNBvLns
2023-04-03 17:54:30 A review of nanomedicines for heart and vascular indications "Nowhere is this more evident, important and impactful than in cardiovascular medicine." https://t.co/mcoWBDok3c @NatureCVR https://t.co/ZQCMAgGJ20
2023-04-03 16:07:53 It's very expensive to train #AI large language models, quantified, making this unlikely to be achievable in academic institutions https://t.co/lDNrKtscgV https://t.co/5coO3yR4up
2023-04-03 15:49:14 @NatMachIntell https://t.co/HHfMoOrX4O
2023-04-03 15:45:23 A blueprint for multimodal graph #AI learning https://t.co/zATisTNBZk outstanding perspective piece by @YEktefaie @marinkazitnik @GDasoulas @ayushnoori @MahaFarhat @harvard_data @HarvardDBMI https://t.co/Dr1SkcDJLA
2023-04-03 15:16:13 Important work by @NouaillesLab and colleagues @ewyler @ChariteBerlin @FU_Berlin entering clinical trials https://t.co/uxglb1PmJQ
2023-04-03 15:16:12 A nasal vaccine induced superior mucosal and systemic immunity vs #SARSCoV2 variants compared with mRNA (Pfizer) and adenovirus-vector vaccines by serology, histopathology, scRNA -seq in hamsters @NatureMicrobiol https://t.co/N2DVNyUPIA https://t.co/YjsDRUy7aj
2023-04-01 06:11:42 @OpenMedFuture @Twitter @verified @SubstackInc Better business model? https://t.co/G6835BLBrL
2023-04-01 06:06:50 @WorkmanLesley Many thanks
2023-04-01 05:23:14 I'm with @DanRather and so many others who I respect, follow and trust on this https://t.co/x4WaZP1dOY
2023-04-01 04:06:43 @LMetermaid @Twitter @verified @SubstackInc https://t.co/b6jcsh9ZJK
2023-04-01 03:55:55 @Arriadna @Twitter @verified @SubstackInc Thanks. Exactly what’s happening
2023-04-01 03:35:31 Wouldn't pay @twitter for a blue After >
2023-04-01 02:36:29 RT @loscharlos: Spoke with @Nature about how it’s incredibly perplexing for NIH to be prioritizing #LongCovid clinical trials that will add…
2023-04-01 00:30:19 Two more new publications and on #AI for surgery by this outstanding team https://t.co/TK7Rrsdjrq
2023-03-31 20:20:13 RT @MarkELindsay: Pleasure to write this editorial with @EricTopol describing our present and future work applying #AI to genetic and clini…
2023-03-31 20:10:21 Potential concern raised by these variants on T cell immunity https://t.co/bfuUvZKyZb
2023-03-31 20:10:20 Continuation of USA=XBB variants with XBB.1.9.1 gaining and XBB.1.16 (big in India) in the background showing more growth advantage https://t.co/jjl2AnOYb5 Unclear whether any clinical outcomes will be affected by transition from XBB.1.5 to these recombinants w/ added mutations https://t.co/yTXUHM5Sj1
2023-03-31 19:46:08 RT @jburnmurdoch: The result is that the US is the only developed country where even if you strip out all Covid deaths, life expectancy sti…
2023-03-31 02:33:40 Dysmorphic, widened aortas are quite common
2023-03-30 23:51:31 Using #AI to predict and ultimately prevent aortic dissection Our new @TheLancet digital medicine essay https://t.co/zTPk4MtrD6 @MarkELindsay @patrick_ellinor @jpirruccello https://t.co/oqjyHRUTyr
2023-03-30 19:50:42 RT @TCLawry: If you want to move beyond the hype surrounding GPTx and its application to medicine, read this assessment by @EricTopol of a…
2023-03-30 19:30:06 The connection between obesity and autoimmunity https://t.co/qJl1XbzCad @ScienceMagazine w/ @ScienceVisuals https://t.co/7LmkotJVLg
2023-03-30 18:33:00 Using #AI to enhance the performance of surgeons https://t.co/qsKA2wMQdQ @natBME @AjhungMD @DaniKiyasseh @Runzhuo_Ma @haqueward @ddonoho @AnimaAnandkumar https://t.co/US3c6GrZdU
2023-03-30 18:20:26 RT @davidrliu: Today we report in @ScienceMagazine a one-time base editing treatment for Spinal Muscular Atrophy (SMA), the leading genetic…
2023-03-30 01:40:14 Here is one example from the book where #GPT4 is coaching the doctor to be more sensitive and empathetic https://t.co/TFFzjH06jC https://t.co/nz9UeBols6
2023-03-29 23:41:04 @AndrewYNg Thanks for this important thread, Andrew
2023-03-29 21:38:17 @ATabarrok Intentional. Thanks for your close read, Alex
2023-03-29 21:28:54 This is the #AI in medicine review article with historical context and a short section on chatbots https://t.co/grbBThRROQ
2023-03-29 21:08:49 Link for the #GPT4 paper https://t.co/bHgUgFzPsf
2023-03-29 21:05:00 New @NEJM Marked reassurance that the bivalent BA.5 vaccine is not associated with increased clotting events https://t.co/LurDno0QBD "We previously found no increase in the incidence of stroke, acute MI, or pulmonary embolism after the administration of the monovalent vaccine." https://t.co/u44yk7aVoy
2023-03-29 21:01:00 The @NEJM is getting serious about covering #AI in medicine with a new series and journal. A #GPT4 preview, review and editorial today This important advance is covered in-depth in a new book https://t.co/hGyrJt4yt7 https://t.co/NeOeOGtxsb
2023-03-29 18:51:38 Discovery of a "molecular syringe": new way to deliver functional proteins into human cells with very high efficiency that exploits #AlphaFold, #AI, and nature https://t.co/yvlBaXBCZO @heidiledford https://t.co/ImfwywvNJ0 @Nature @zhangf and colleagues
2023-03-29 17:32:23 Is this really worth full page ads @nytimes and @washingtonpost today? https://t.co/QAeHINKBRc
2023-03-29 17:01:54 Our #AI times :-) @speedbumpcomic https://t.co/mCmCcqd2jz
2023-03-29 02:16:38 RT @AI_4_Healthcare: Leave it to @EricTopol to whet my appetite for the next big #AIinHealthcare book. Can't wait to read it. Hey @peteratm…
2023-03-28 21:59:19 "I struggle to understand why the healthcare systems of the world’s richest countries are not yet using all the knowledge that science has provided to bring more help to.. millions of others living with pain." https://t.co/STqC1VB2qh by @lucy_os @Nature https://t.co/YynX6ATaLX
2023-03-28 21:43:51 Wild animals suppress misinformation but we can't https://t.co/UWvTtNV58j @PNASNews https://t.co/sJm6mVaBnL
2023-03-28 21:25:23 #ChatGPT is so old Here's what GPT-4 (and beyond) can do for healthcare https://t.co/hGyrJt56iF
2023-03-28 21:20:16 For uninitiated healthcare personnel, #AI can guide obtaining high quality ultrasound images in patients with trauma https://t.co/95o99AYh3v @JAMANetworkOpen https://t.co/xWRu9RRGAH
2023-03-28 20:06:24 RT @LGlaucomflecken: New episode! We had a fascinating conversation with @EricTopol about how AI will affect the medical profession in p…
2023-03-28 05:46:06 RT @Ban_Kawas: @EricTopol @peteratmsr @goldbergcarey @zakkohane >
2023-03-28 02:00:58 RT @chrishendel: This was a fascinating read! The GPT-x Revolution in Medicine by @EricTopol Review of a new book with 6 months of asses…
2023-03-27 22:25:38 @dineshxr @peteratmsr @goldbergcarey @zakkohane Thanks. Fixed.
2023-03-27 22:17:43 I wrote about GPT-4 in medicine and a new outstanding book by @peteratmsr @goldbergcarey @zakkohane coming out soon https://t.co/hGyrJt56iF
2023-03-27 22:13:43 @loscharlos not --1000% thanks to all you are doing to maintain awareness and education with the latest information every single day
2023-03-27 22:11:03 And this :-( https://t.co/J7FSXqKssO
2023-03-27 19:48:46 Brings this piece to mind and that we need to markedly accelerate and quadruple efforts for effective treatments. Much too little is being done. https://t.co/X4B0k6ubDm #LongCovid https://t.co/Z1R7ztmZTI https://t.co/hTh6hmDwQd
2023-03-27 17:57:02 Does regular physical exercise lead to cognitive gains across the lifespan? https://t.co/p1XWeItOJv The causal evidence from the aggregated 24 meta-analyses of randomized trials is "far from conclusive" @NatureHumBehav
2023-03-27 17:09:51 Pairs with this https://t.co/1pTi8V8QMY
2023-03-27 16:48:07 Our #AI times
2023-03-25 18:46:32 @Cacciamani_MD Thank you!
2023-03-25 18:07:45 RT @chrischirp: 9. To sum up: Long Covid is real &
2023-03-25 05:46:19 @Brad49M @DelthiaRicks @DFisman @BogochIsaac Yes. Aligns with this report. Real potential for nasal spray broad neutralizing antibodies that will be variant-proof and potentially quite durable https://t.co/Ao7LT6haaV
2023-03-25 03:34:33 @harari_yuval @tristanharris @aza Thanks for cheering us up, Yuval
2023-03-25 00:58:47 RT @LongCovidAdvoc: Yes @EricTopol calling out the Denial Dismissal Unempathetic Biopsychosocial Model of #LongCovid (This includes p…
2023-03-24 22:40:37 The key and under-appreciated dimension of time and our circadian clock in the diagnosis and treatment of cancer https://t.co/k0v8gEcYrk @TrendsCellBio @CellCellPress @ETH_en https://t.co/6NoSlHOsvP
2023-03-24 21:49:41 While there has been progress in ways to reduce the likelihood of developing #LongCovid, there's very little to show for any treatment. Small randomized trials of Paxlovid and Naltrexone are underway. Reviewed here https://t.co/NyRhyCiVJO https://t.co/BY30d03eNv
2023-03-24 20:15:21 The potential for inducing pluripotent stem cells (iPSCs) from a person to treat Parkinson's disease, congenital heart disease, and many other incurable conditions is going to be assessed in multiple clinical trials https://t.co/HiCQC1tgFz by @NidhiSubs https://t.co/ddvx3t1z5m
2023-03-24 19:44:52 USA = XBBs https://t.co/jjl2AnOYb5 XBB.1.9.1, XBB.1.5.1 showing up
2023-03-24 19:27:16 RT @chrischirp: LONG COVID : Clips from today's @IndependentSage from world leading experts. PLEASE WATCH! 1. @EricTopol We know a LOT M…
2023-03-24 03:48:04 @inducekarmaaa @NewsfromScience @ScienceMagazine @jcouzin Perhaps you haven't read many essays I've written on that very topic. There is NO minimization coming from me. 1 example https://t.co/PcV84bUOwy https://t.co/MdHYgerJvw
2023-03-24 03:33:18 RT @zalaly: Paxlovid can prevent #LongCovid The latest from our team in @JAMAInternalMed by @Biostayan @TaeyoungChoi93 @zalaly A thread…
2023-03-23 21:48:18 Thanks @substackInc! https://t.co/e1AEPEZCkP https://t.co/YllXW9J82k https://t.co/FHjr572JWR
2023-03-23 20:08:42 RT @thehowie: Four principal ways to Preventing Long Covid, with *NOVID* at the top of the list. Great piece from @EricTopol https://t.co/1…
2023-03-23 20:05:06 Summary of data supporting less #LongCovid with Omicron and its subvariants (along with more immunity built via vaccinations, infections, and their combinations) https://t.co/2Z1OxL3w2B @NewsfromScience @ScienceMagazine by @jcouzin
2023-03-23 19:37:33 A prospective, multicenter study of label-free #AI classification of brain tumors (diffuse gliomas) with 93% accuracy in <
2023-03-23 18:24:15 The #SARSCoV2 virus impact on our epigenome https://t.co/T0AxihtgJ9 @NatureMicrobiol may help "pave the way for unraveling the molecular basis of #LongCovid for its intervention" https://t.co/5SNK6JvGTf
2023-03-23 18:18:47 Links to the new @JAMAInternalMed #LongCovid papers Paxlovid https://t.co/4g04GXeYUo by @zalaly and colleagues Vaccination https://t.co/N0hZ3UPCjl
2023-03-23 16:33:09 @WBryanH @JAMAInternalMed @substack Yes, vaxxes are spike-specific for inducing antibodies in contrast to full virus exposure (including nucleocapsid protein) from infections
2023-03-23 16:24:20 Link to the post https://t.co/NyRhyCiVJO
2023-03-23 15:02:00 In @JAMAInternalMed today, 2 new papers on #LongCovid, one a systematic meta-analysis showing protection associated with vaccination--a 43% reduction, and the other with Paxlovid--a 26% reduction I wrote about this w/context in a new @Substack post https://t.co/eARtGCcZyv
2023-03-23 00:45:29 Another coffee study published today https://t.co/GAPcOWIXf2 https://t.co/VZ7g6lvRqe
2023-03-23 00:03:15 Now another large language model GPT-4 has scored >
2023-03-22 21:12:17 More today on this exciting potential outgrowth of the mRNA nanoparticle platform https://t.co/kQNleLFyqd by @kathleen_neuzil @NEJM https://t.co/Ptb0xSoGp0
2023-03-22 21:04:13 "Coffee drinkers have consistently had reduced morality in prospective cohort studies, but the mechanism for this result remains unknown"
2023-03-22 21:02:32 A randomized trial of coffee consumption showed no increased of premature atrial contractions (PACs). Secondary endpoints (hypothesis-generating): more PVCs, more physical activity, ~30 mins less sleep, no change in glucose levels https://t.co/7KDnmcpcOC @NEJM https://t.co/L9ofCbBsEr
2023-03-22 19:31:22 @dfocosi @ScienceTM Agree on all points, Daniele. There have been several bnAbs with variant-proof potential (not this one) and the concept of multi-year protection via this path is alluring, to say the least, for immunocompromised individuals
2023-03-22 18:41:37 Agree on transformative impact of #AlphaFold but that wouldn't be classified as a LLM https://t.co/7bit917Bfj
2023-03-22 18:23:48 Generative AI, LLMs: “This is going to change everything about how we do everything. I think that it represents mankind’s greatest invention to date."--@MundieCraig (a bit of hype) https://t.co/amQvYIZovL @tomfriedman Even healthcare? https://t.co/lvIjbPjZIB by @bellelin_ https://t.co/GvKsQs6vCu
2023-03-22 18:05:44 Potential of 3-year protection from Covid with a broad neutralizing antibody https://t.co/5QTuMuIc4i @ScienceTM https://t.co/nHQlkt7Dnb
2023-03-22 17:12:22 @LizSzabo He consented!
2023-03-22 16:43:51 Beethoven's DNA https://t.co/XgNfMtAOqI Identified hepatitis B and other risks for liver disease, no genetic explanation for hearing loss @CurrentBiology https://t.co/HavKGkYzp6 https://t.co/4zyLBHVpHQ
2023-03-22 05:17:53 Debunking the obesity-survival paradox for patients with heart failure https://t.co/S6gzar7Dzq emphasizing BMI as a poor metric https://t.co/yFpQe7aIEA
2023-03-21 18:26:09 This action is months overdue. The FDA has left people of advanced age and immunocompromised vulnerable https://t.co/n8BLZAPGBj by @StephArmour1 w/ @mtosterholm @BarneyGrahamMD https://t.co/KVLeWZHoKB
2023-03-20 23:07:45 @DocJeffD @AnnalsofIM Exactly. A reason for early termination of the trial and a good news that is reinforced by multiple other reports https://t.co/6iqDJ3oV1b
2023-03-20 22:28:53 @wgpWoman Thank you!
2023-03-20 22:10:28 A randomized trial of a blood thinner after severe Covid to prevent clothing events. Summary of result: "highly compatible with estimates of efficacy ranging from a 56% reduction to a 95% increase risk of apixiban compared with placebo https://t.co/SqsS7OCwKq @AnnalsofIM https://t.co/mZCcbXwKBf
2023-03-19 20:02:05 On neural innervation of cancer tissue and mind-body interactions https://t.co/9JzBpfggPY by @david_j_linden https://t.co/Rq4bu8zj43
2023-03-19 19:27:38 After the first global reduction of life expectancy since World War II, a path towards "longer and healthier lives" https://t.co/FabQ5X6RsK by @Atul_Gawande https://t.co/vCbA13L490
2023-03-19 19:11:44 A large retrospective electronic health record study of #LongCovid, with many limitations (some acknowledged) https://t.co/fitmwC7NNe w/ @zalaly @VirusesImmunity and good thread dissecting it https://t.co/wrlrn1UK9l https://t.co/5GTgdT97VD
2023-03-17 22:56:07 RT @JPWeiland: Short-term forecast for the US looking good! XBB.1.5 is receding with nothing to take it's place in the near term, with n…
2023-03-17 22:27:30 @ProperLookout Thanks!
2023-03-17 21:18:35 Why this can be considered a good sign https://t.co/qTgIEjnydz
2023-03-17 18:25:23 Thanks to all the readers and subscribers of my Ground Truths newsletter. It’s going to a new, expanded phase https://t.co/ldL5SfDzdL https://t.co/JBuy0H2Sco
2023-03-17 18:18:45 @DeepaRamani1 @ScienceMagazine Much appreciated
2023-03-17 18:16:43 @Nancy_had_enuf Thanks for noting. Yes, on Mastodon and Post. But will be using substack as my primary means of getting stuff out. https://t.co/ldL5SfDzdL
2023-03-17 17:35:19 The vital role of patients and the public in guiding #LongCovid research https://t.co/V2xLnrMLIi @NatureMedicine by @AshRouten and colleagues https://t.co/6qif9SHjUB
2023-03-17 17:18:06 All remains quiet on the new variant front https://t.co/jjl2AnOYb5 https://t.co/uw5AQ1ftNY
2023-03-17 04:38:54 RT @TCLawry: If you want to understand where GPT and Large Language Models are taking us in health and medicine, this is the piece to read.…
2023-03-16 22:10:48 @FurnessColin Thanks for your input. To quote the report "the majority of recovered COVID-19 patients had normal olfactory function based on three-year follow-up." I didn't write anything about brain function or tissue
2023-03-16 20:48:05 Loss of smell after Covid: by 3-years (the longest follow-up study to date) >
2023-03-16 20:09:40 The ceramide story and how it may add to cholesterol for gauging risk and intervening for heart disease https://t.co/gFlZfPaWeN @ScienceMagazine https://t.co/MvX8eLmOLA
2023-03-16 18:37:23 Why are so many young people getting colon cancer? https://t.co/fcADufmq22 @ScienceMagazine w/ @ScienceVisuals by @GiannakisLab @KimmieNgMD @DFarberYoungCRC @DanaFarber https://t.co/wtS8RnXzeQ
2023-03-16 18:25:47 One of the most important advances for #AI in life science has been #AlphaFold. The prediction of proteins from amino acid sequences at atomic level has a new large language model, ESM-2, from @Meta https://t.co/Hs4H8wW4eS @ScienceMagazine https://t.co/m9RXmWviu7
2023-03-15 20:54:37 Not everyday a large language model scores 85.4% on the US medical licensing exam (USMLE) Implications https://t.co/aOWx7kAw4G https://t.co/0Ehb9BMnPT
2023-03-15 18:24:42 @ScienceTM Distinct and longer term immune protection induced by Prior Covid + vaccination (hybrid immunity) https://t.co/swk5Mz0ove @CIRI_Lyon @CIRI_Bcell_lab https://t.co/IcApu7L3Vm
2023-03-15 16:41:13 An important conversation with @HeartBobH about faculty, freedom of speech, the role of academic Iinstitutions and the Covid pandemic. With @cuttingforstone +transcript @Medscape https://t.co/XevAfk4npk
2023-03-15 16:16:18 RT @sheencr: Today is #LongCovidAwarenessDay LongCovid is a condition comprising often severe symptoms that can affect many different org…
2023-03-15 02:53:44 Nothing to see here for the numbified https://t.co/OYKQV32gvz https://t.co/sX20RvgITN
2023-03-15 00:06:12 @MatisseMs @ScrippsRTI @scrippsresearch Thank you!
2023-03-14 23:23:58 A thoughtful editorial on #ChatGPT in healthcare by the editors @NatureMedicine https://t.co/thDj3UteMy There's a lot going on today with release of GPT-4, success of Med-PaLM 2 on USMLE. Put in context here https://t.co/aOWx7kAw4G https://t.co/31tiv9dWiV
2023-03-14 21:11:17 RT @ScrippsDTC: In this 2009 @TEDTalks, @EricTopol highlights several of the most important wireless devices in medicine's future. Today,…
2023-03-14 20:43:58 Today @GoogleAI's Med-PaLM 2, was just reported to score 85% of the US Medical Licensing Exam, up from 67% a few months ago https://t.co/W1Sz2CMI3C Generative #AI is going to rock medicine I just wrote about it https://t.co/aOWx7kAw4G
2023-03-14 19:50:16 RT @fammedfeisty: A really important read! Especially the part near the end about the potential for AI and LLMs to greatly reduce the admin…
2023-03-14 19:49:10 @j_corey02 https://t.co/DyGfAylUO6 It originally stated, incorrectly, that Eric Topol had declared the Covid pandemic “to be over”. In fact, while Dr Topol stated there are multiple indicators that we are entering an endemic phase of the pandemic, he does not believe the pandemic to be over
2023-03-14 17:10:24 The remarkable story of @DrFejzo's perseverance to find the biologic basis for a condition she suffered from and to help establish leadership and advocacy for it @HGMoms https://t.co/bBmEm3pueX by @scienceofmom
2023-03-14 04:48:47 RT @xkcd: Lymphocytes https://t.co/yTkMCQayZv https://t.co/2AeyEu6dFa
2023-03-14 04:31:12 @tmprowell Thanks Tatiana!
2023-03-14 01:24:15 On the mission of communicating science and medical information to the public. A newsletter about this Ground Truths newsletter and an announcement about where it's headed. All proceeds to be donated to @ScrippsRTI @scrippsresearch https://t.co/ldL5SfDzdL
2023-03-13 23:48:00 @annbmcguire123 Thanks! And @dr_kkjetelina is a gem
2023-03-13 23:29:38 @LLColorMeBlue Much appreciated!
2023-03-13 23:10:00 AI isn't "superhuman intelligence" but it's interesting that humans can up their game by learning from it https://t.co/6J619boqDu @PNASNews @jinkimsci @basvanopheusden @cocosci_lab https://t.co/M5PaDcUwqF
2023-03-13 22:59:19 A new and very good review on the emerging impact of #AI for cancer diagnosis, prognosis and treatment https://t.co/0o2Fyn2btP @CellCellPress @KyleWSwanson @ericwu93 @AshAlizadeh @james_y_zou @StanfordMed @StanfordEng https://t.co/Z5fweUWZpP
2023-03-13 21:43:24 RT @SubstackInc: "Unfortunately the toxicity of twitter has progressively gotten worse, while at the same time the ability to reach followe…
2023-03-13 20:12:07 A new post about the Ground Truths newsletter and where it's headed https://t.co/ldL5SfDzdL https://t.co/ixSk1fbtIq
2023-03-13 15:22:58 Graphic derived from this @NEJM report https://t.co/AJHTK3HesC https://t.co/f0XXHcYHvK
2023-03-13 15:05:34 Two data-driven tips to optimize vaccine immune response 1. Sufficient Sleep https://t.co/pelUhPzfOi @CurrentBiology 2. Same arm https://t.co/fqBXV8HQtq https://t.co/SPhwRrNV6j
2023-03-13 14:29:08 35% of hospital admissions with medical errors/ adverse events, according to an 11-hospital Massachusetts study. Some are being addressed with #AI tools https://t.co/IOSULOeWit by @LauraALandro https://t.co/OymOwpZdbu
2023-03-13 14:14:41 Better, but ~400 Covid deaths per day is unacceptably high, given so many are preventable https://t.co/ShoeHVejq0 https://t.co/hRwfdwTAxM https://t.co/CX1JkcOpPA
2023-03-13 03:55:02 @AlisaValdesRod1 @ewencallaway Agree. Thanks
2023-03-12 22:32:36 @DrMaireadDB @j_corey02 @AlanEnglish9 @Independent_ie @PatKennyNT @NewstalkFM Thanks. I notified @PatKennyNT @NewstalkFM as well
2023-03-12 22:07:32 RT @zalaly: @EricTopol @ScienceMagazine @NEJM This is absolutely on point. One of my favorite quotes from an Op-Ed @EricTopol wrote in @…
2023-03-12 21:19:45 Despite an estimated 10-20% of an "Omicron-like event" in the next 2 years, as I reviewed here https://t.co/qTgIEjnydz Hard to find any major initiative to develop better Covid vaccines for broader, more durable protection &
2023-03-12 21:01:16 There are over 50 published papers that identify such candidate "universal" vaccines or potent broad neutralizing antibodies that can be used as a template for such vaccines. A sampling below https://t.co/QzLzYEGTGX
2023-03-12 20:51:56 In 2021, there were urgent calls for a universal coronavirus vaccine https://t.co/V71aBHAKlr @ScienceMagazine https://t.co/XsOwK7Pcnx @NEJM There is little to show for this, despite abundant candidates vs β-coronaviruses (#SARSCoV2 variant-proof) https://t.co/tss9IivpnA
2023-03-12 17:15:16 @j_corey02 Thanks Julia. I have written to @AlanEnglish9 demanding a correction about this misinformation @Independent_ie
2023-03-11 22:24:27 It's complicated. High levels of autoantibodies have been demonstrated in some people with #LongCovid. https://t.co/NwXVISGlNd by @VirusesImmunity @PutrinoLab https://t.co/n1hxFYd4Fk by @LabHeath But some of these antibodies appear to be protective https://t.co/XlgMCwvaWd https://t.co/RvwrsnXAVg
2023-03-11 20:08:08 RT @EricTopol: My conversation this week with Prof @linseymarr, a civil engineer and leading authority on air quality, viruses, and the imp…
2023-03-11 19:36:55 3+ years in, it's sad and notable that so much work has to go in to providing the evidence (for a respiratory virus) they work. https://t.co/j9qf2ul7rA https://t.co/zEZswCHp4g https://t.co/8wFaqlj7iS
2023-03-11 15:58:24 @BiffAndFinn @Mirella_PhD @brownecfm Dr. Mirella has made a repeated false accusation that I deleted a tweet--which I did not. And thank you for explaining the lack of need for "damage control," another bogus assertion she has made.
2023-03-11 00:59:42 There's a lot of confusion about what a Covid endemic phase means. I think this short essay by @ArisKatzourakis @Nature is the best description I've seen https://t.co/J16ZGW86lu "a disease can be endemic and both widespread and deadly" https://t.co/5saXi5Q9z7 https://t.co/e2MPzrrSPH
2023-03-11 00:24:01 RT @brownecfm: 1. This is a must-read from Irish journalist, Tess Finch-Lees, dissecting the recent declaration from Professor Luke O'Neill…
2023-03-10 20:43:41 Yet another pan-sarbecovirus (#SARSCoV2 variant-proof) vaccine candidate, this one with effective neutralization vs the BQ.1.1 and XBB variants in non-human primates https://t.co/ftkVFKAYP5 @PNASNews Bu none of these have progressed to clinical trials https://t.co/YratTfR9fU
2023-03-10 17:23:48 More on this, including declaration from @cochranecollab director that their review interpretation was "inaccurate and misleading" https://t.co/eRAbEAIq6C @nytopinion by @zeynep
2023-03-10 15:55:01 The pandemic at 3 years https://t.co/rvOR5COfai by @CarlaKJohnson @AP
2023-03-10 15:37:37 Unchanged US status for #SARSCoV2 genomics with XBB.1.5 accounting for 90% of new cases, no new variants showing growth advantage https://t.co/jjl2AnOqlx I reviewed implications here: https://t.co/qTgIEjn0o1 https://t.co/PST3C7wr9l
2023-03-10 13:48:20 @MichaelColey @MichaelSFuhrer That's correct. I did not say/write "the pandemic is over"but that it appears we've entered an endemic phase (think wavelets rather than major waves). And i reviewed the current high baseline of adverse outcomes and risk of a new major variant family https://t.co/qTgIEjnydz
2023-03-10 03:18:49 @JusDayDa @Twitter That’s what I heard now from hundreds of people who follow me
2023-03-10 03:11:34 This one and most of my @twitter posts are being suppressed from being seen by followers. Whether it’s attributable to intent or default is unclear. I’ve been on this platform for 13.5 years and the ability to share information is now significantly impaired
2023-03-10 00:03:43 3 years in, the status of #LongCovid Editorial @TheLancet "Progress has been excruciatingly slow due to lack of attention and resources" https://t.co/qdQ9nF2Uon https://t.co/fxauyKYAAr
2023-03-09 23:26:40 @Sara_Sawyer_ @ScienceMagazine @ScienceVisuals @CJayWarren That kicker was powerful! Great and much needed piece
2023-03-09 22:18:22 @covid19_alex Many thanks
2023-03-09 21:22:27 @EcoSexuality Yes
2023-03-09 21:15:48 On Pandemic preparedness "Given the profound consequences of virus epidemics and pandemics, and the highly flammable tinder of 8 billion people crowded onto the planet" @ScienceMagazine w/ @ScienceVisuals https://t.co/gZRFmIr0mQ by @CJayWarren @Sara_Sawyer_ https://t.co/UF8gm5VGjm
2023-03-09 20:55:02 Beyond a month post-Covid, there's a significantly elevated risk of clots, including heart attacks and strokes that has been established by multiple studies, with reduced risk among those vaccinated https://t.co/6iqDJ3oV1b https://t.co/7bXyGZiugc
2023-03-09 20:46:26 A prospective study implicating the gut microbiome and its interconnected immune response for hospital-acquired infections https://t.co/MB82FjpscM @NatureMedicine https://t.co/UzrLLZmX1k
2023-03-09 19:46:36 Update: People age 65+ are now eligible to participate https://t.co/2FHe53TKeI
2023-03-09 16:38:20 How Covid infection induces DNA damage https://t.co/I8FKt5mreK @NatureCellBio https://t.co/qAHpRffdEv
2023-03-09 16:21:29 Current treatment of blood pressure, the most common chronic medical condition, is hit or miss, with multiple drug classes and frequent lack of adequate control. What if relevant gene variants were screened? https://t.co/ohpGLuHpkN @ScienceTM https://t.co/JxDDhL04Tj
2023-03-09 16:04:27 The effects of radiation therapy Bad: Heart
2023-03-09 15:47:56 piece is by @adampiore (not adampio)
2023-03-09 15:35:09 Looks familiar https://t.co/5XBqDVmKw7 @adampio @Newsweek (and the latter isn't ready, or even close) https://t.co/nDatHpTM9z
2023-03-09 01:24:29 Will we get "Omicronized" again? https://t.co/qTgIEjnydz https://t.co/Bera1D7BEc
2023-03-09 00:49:49 Alrighty then https://t.co/iZO9avfbS2 @Uroweb #EAU23
2023-03-09 00:38:53 RT @ahandvanish: This is so exciting (not as a brag!), but because it concretely shows huge increased interest in #LongCovid, including by…
2023-03-08 23:59:01 A new systematic review of the Covid pandemic's impact on mental heath provides some reassurance from an aggregate of 137 unique reports https://t.co/6Ir0pMPB0g @bmj_latest https://t.co/NwBlwqeUH6
2023-03-08 19:22:54 The impact of pandemic school disruption (cohort, grades 7-9, in Germany), with the intelligence test gap in results persisting out 16 months https://t.co/yhfbrZZp51 https://t.co/pR9Sbp1PuP
2023-03-08 18:52:56 Our #LongCovid review @NatureRevMicro has surpassed 10,000 @altmetric and 670K downloads @ahandvanish @LisaAMcCorkell @julialmv https://t.co/EgO7gtFvoe https://t.co/IJukoucvgE
2023-03-08 17:12:08 Along similar lines https://t.co/igjwQB4miX @TheAtlantic by @jdkstern13 "Either ChatGPT will completely reshape our world or it’s a glorified toaster.... the rest of us sit quietly somewhere in the middle, trying to make sense of this strange new world."
2023-03-08 17:07:47 Discovery of specialized neurons in the upper airway that, when removed, disrupted sickness from a respiratory virus, similar to the effect of ibuprofen or aspirin https://t.co/RGpFboFRbY @Nature @justsaysinmice @HHMINEWS https://t.co/NmRi1e8rN5 https://t.co/dP3nF9uS0i
2023-03-08 16:15:12 A succinct summary of the findings https://t.co/80zIGxMXYt by @PamBelluck https://t.co/RXLEimEzD7
2023-03-08 15:56:46 @Mike_Honey_ Here is the graph from my post. XBB.1.5 was not dominant in the US in January
2023-03-08 15:39:04 @WomenInTheBurbs Both
2023-03-08 15:24:13 The first randomized trial to show that some #LongCovid can be prevented, and other Covid updates https://t.co/qTgIEjnydz https://t.co/5kH20Tpdgb
2023-03-08 15:13:53 @thehowie Thanks Howie!
2023-03-08 14:54:34 The —is bigger better ?— for LLM #AI When #ChatGPT and large language models get exponentially bigger (such as GPT-4 at 100 trillion parameters), will they perform better? An outstanding @nature feature https://t.co/efnazvOKBi by @anilananth https://t.co/TJMx1blJM4
2023-03-08 06:15:23 @Mia__Kennedy Thank you!
2023-03-08 03:20:47 Some positive news on Covid https://t.co/qTgIEjnydz
2023-03-07 20:01:20 A nasally administered monoclonal antibody in patients with mild-to-moderate Covid for favorably modulating the hyperactive T cell immune response https://t.co/ZdkvYN74Ta @PNASNews https://t.co/IFoLSgsK53
2023-03-07 18:58:08 Indoor air quality: We're not paying attention to it or doing anything substantive about improving it. It's long overdue to get serious and all over it. a new @Nature feature https://t.co/k2LB6MkYN2 by @dyanilewis https://t.co/17vy1yURSg
2023-03-07 18:12:27 A very good thread by @zalaly on this new paper https://t.co/yE0uAE2gfF
2023-03-07 17:25:27 RT @EckerleIsabella: All true at the same time: 1) #SARSCoV2 is entering an endemic phase, new variants not causing massive infection waves…
2023-03-07 16:55:39 Why #LongCovid can affect virtually every organ system in the body? Where there is high level of ACE2 expression, the cellular entry receptor or #SARSCoV2 Connecting the dots https://t.co/P0ilk3fj9s https://t.co/EgO7gtFvoe https://t.co/z3d7SCi0xz
2023-03-07 16:39:36 @DKMedJournalist That's not the correct interpretation. The 95%CI are overlapping (below age 45 and above) and there is not a treatment by age subgroup interaction.
2023-03-07 16:06:20 Here's a good summary graphic and highlighted abstract https://t.co/NWKZJrOKIW
2023-03-07 15:58:55 The gastrointestinal impact of #LongCovid https://t.co/2lk7cJ0qsR by @zalaly and colleagues Just published @NatureComms Broad risk of GI adverse outcomes after 30 days, worse with severity of Covid, but clearcut increased predisposition even in those without hospitalization https://t.co/W7aneWVcK2
2023-03-07 15:45:09 https://t.co/SgFazpBINK
2023-03-07 15:30:39 Two very good articles on Postural Orthostatic Tachycardia Syndrome (POTS) #LongCovid https://t.co/KeTfzQKxde @PostHealthSci by @AmandaMoMorris https://t.co/m8CJHs6OM2 @bmj_latest by @trishgreenhalgh @AnaBelenEspino2 https://t.co/JQu8MXEyEm
2023-03-07 15:21:22 @Bob_Wachter Given the lack of side effects and cost for a 2 week course, I think these data support use of metformin now. We do need more studies (for a solid replication), factorial design w/ Paxlovid. There are no subgroup treatment interactions so unclear how to partition its use
2023-03-07 14:53:55 @Rob_Messinger Thank you!
2023-03-07 14:38:41 Front page @latimes AT least 95 passages of plagiarism in a #1 @Amazon book (subtitled "Nature's Lessons for a Long and Happy Life") https://t.co/6JVSLNiQFB https://t.co/btGUjhqH44
2023-03-07 01:59:58 For a total takedown of the @cochranecollab report See @tomaspueyo https://t.co/0dp9FSwQ3X For the full body of evidence on masks See @trishgreenhalgh https://t.co/h0pUsWeYeb
2023-03-06 23:52:31 That's right. https://t.co/DRX2Aq5Nax
2023-03-06 23:40:35 @CDCgov_parody @BramanteCarolyn I do.
2023-03-06 23:06:33 Genetic conditions involving impaired Type 1 Interferon response predispose to severe COVID pneumonia (previously thought to only promote susceptibility to bacterial infections) https://t.co/jF8KENVYYf @JExpMed https://t.co/qU4wF7GmNq
2023-03-06 19:16:32 Dose of metformin: 1 pill (500 mg) day 1, twice daily for 4 days, then 1 in AM, 2 in PM for 9 days Cost as low as $1. https://t.co/iSK9IYrjar
2023-03-06 18:35:17 Worked consistently across key subgroups https://t.co/8EF7hHVuhQ
2023-03-06 18:35:16 Very good news Metformin significantly helped prevent #LongCovid in a placebo-controlled randomized trial, a 42% relative reduction https://t.co/go20dm3NnN by @BramanteCarolyn and colleagues https://t.co/4uUZVINq62
2023-03-06 16:15:16 Self-directed Abs (autoantibodies) against specific chemokines (cell secreted proteins) are linked with protection from #LongCovid https://t.co/2dsP0ifxq4 @NatImmunol https://t.co/80uncmfTSp
2023-03-06 15:56:47 RT @EricTopol: We've known that Covid can predispose towards clots. But what about late effects, months after an infection? A summary of th…
2023-03-06 15:45:42 From the article https://t.co/HIOyZwJDWC
2023-03-06 15:35:45 When Medical #AI makes the headlines https://t.co/22FnYHGLJ2 @satariano @CadeMetz https://t.co/WhnUHcwjRS
2023-03-06 01:59:55 Good to see @LesleyRStahl find out what happened to Sydney @bing #ChatGPT #AI :-) https://t.co/XAjQQAn8Fh @60Minutes https://t.co/GVH3M3XfBC https://t.co/ZcvH6MYBqH
2023-03-05 16:54:58 The potential for #AI to predict flares in patients with ulcerative colitis as well or better than pathologists in a multicenter prospective study #IBD https://t.co/Lw3PYpj2hO @AGA_Gastro by @MariettaIacucci @tommasoparigi and colleagues https://t.co/l7Msqr4ewu
2023-03-05 16:39:30 Smartphone imaging to detect anemia in a vulnerable, understudied pediatric population with sensitivity 93%, specificity 90% in a small cohort https://t.co/7PfeKiHfgf @thomas_wemyss and @UCL @UnivofGh colleagues @PLOSONE https://t.co/yH7UlJQEFG
2023-03-05 16:05:18 We've known that Covid can predispose towards clots. But what about late effects, months after an infection? A summary of the evidence that has been recently updated https://t.co/6iqDJ3oV1b https://t.co/RsoxU166Yr
2023-03-05 10:00:00 CAFIAC FIX
2023-03-02 22:00:00 CAFIAC FIX
2023-02-28 02:54:05 @JN1171 @cmyeaton @dr_kkjetelina Much appreciated!
2023-02-28 02:00:12 @sharongoldman @OpenAI No! :-(
2023-02-28 00:38:19 A fun visit with 2 great epidemiologists today @cmyeaton and @dr_kkjetelina giving a little tour of La Jolla cove https://t.co/0S2WqqCB5X
2023-02-28 00:04:21 This is a unique "bedside to bench to model" study (starting with affected patients to RNA-seq to experimental model) for #LongCovid and may help identify specific candidate anti-inflammatory therapies
2023-02-27 23:59:49 @sfedelelondon @NatureCVR Agree!
2023-02-27 20:35:30 Towards understanding lung scarring in people with #LongCovid and potential treatment https://t.co/mJtlBvKskn Single cell RNA-seq used to identify specific markers (e.g. IL-6, CD47) and blocking these in a humanized mouse model to decrease lung scarring @PNASNews @GerlindeWernig https://t.co/qLEK4TNdtE
2023-02-27 18:14:50 The UK has led the world in human genomics. Can it further become a science superpower? https://t.co/gvzuSDhOyU new editorial @ScienceMagazine by @jameswilsdon https://t.co/OpeqEKSiBg
2023-02-27 17:30:00 RT @tomaspueyo: Do masks work? Recently, some ppl have started claiming it's proven that they don't. Is this true? I dove into the detai…
2023-02-27 16:30:47 The persistent excess of cardiovascular deaths in the United States through the 1st 2 years of the pandemic, consistent throughout 5 Covid waves, even well after surges in cases waned https://t.co/6oXy15KX47 @NatureCVR https://t.co/InSmk1C4v4
2023-02-27 16:18:52 Summary of the multiple recent reports that support autoimmune component of atherosclerosis https://t.co/CW7cKLF9sH @NatureCVR @AndreasEdsfeldt https://t.co/xpweW6l2FS
2023-02-27 16:06:14 A new report from Canada on Covid vaccine related myocarditis in teens among 1.65 million doses (77 cases) https://t.co/yjsfU2o0TY @JAMAPediatrics "the risk of these events remains very rare" reduced further by longer interval to 2nd dose https://t.co/3KY19VeE0P
2023-02-27 15:55:37 There are already several randomized trials showing #AI chatbots can support mental health. What will be the impact of large language models? https://t.co/tUhQJq5RTB @NewYorker @DhruvKhullar https://t.co/0utc60ZSGa @NatureMedicine https://t.co/m8ZT3WQHVJ
2023-02-27 01:00:00 CAFIAC FIX
2023-02-20 17:28:20 RT @CraigJoseph: Thorough overview by @EricTopol of the history of hospital-at-home, the impact that #COVID19 had on #HaH, and what the fut…
2023-02-20 17:20:20 What if you could remove APOE4, the most important genetic risk factor for Alzheimer's disease, from the brain? They did https://t.co/KjSdgdukym @NatureAging by @GladstoneInst @justsaysinmice https://t.co/ycPrG7q219
2023-02-20 16:53:52 The @JAMA_current Editors weigh in on this new trial and the body of evidence that all points to lack of Ivermectin benefit https://t.co/3wCxBV92Sd by @KBibbinsDomingo @PreetiNMalani https://t.co/QXCXuTLFBr
2023-02-20 16:49:04 Nearly all Paxlovid drug-drug interactions can be circumvented by holding the drug or reducing its dose. A quick and practical summary @JAMAInternalMed https://t.co/Fi3Vmxn9fY
2023-02-20 16:18:37 Covid vaccination is associated with significantly reduced incidence of heart attacks and strokes during follow-up. Results of a nationwide @ncats_nih_gov study https://t.co/YsfQ3Olqj0 @JACCJournals https://t.co/H8YvtDAOyJ
2023-02-20 16:06:00 This comes after @cochranecollab review of all evidence from 11 trials + 3 recent randomized trials that were all negative. There are still >
2023-02-20 16:01:31 A new Ivermectin randomized, placebo-controlled trial at high doses for long duration fails to show any benefit, published @JAMA_current today @snaggie1 @boulware_dr and colleagues https://t.co/PyT6k8Q5Jm https://t.co/oe227wjFtF
2023-02-20 14:50:30 Our digital times :-) by Hartley Lin and @MatttDavies https://t.co/DPmjlSZoIF
2023-02-20 01:56:34 RT @NHLBlackhawks: A statement from Captain Jonathan Toews https://t.co/tn7CP57bQN
2023-02-20 01:16:52 These 2 papers were the most impressive life science achievements of the week (if not much longer). I wrote about their significance and the remarkable progress that is being made in the field of genome editing https://t.co/EGCvhT76ld
2023-02-19 22:45:26 If you want to read about some really exciting biomedical genome editing stuff https://t.co/EGCvhT76ld
2023-02-19 16:39:16 @wunschcritcare Yes, it was your brilliant book I reviewed for Nature.
2023-02-19 01:40:05 @AndrewLBeam @zakkohane @NEJM @arjunmanrai Says a lot about AI in medicine when @nejm starts a dedicated journal
2023-02-19 00:57:20 I just finished a book on the history of polio. It made me think of some interesting contrasts and similarities vs #SARSCoV2 https://t.co/wDlWaeU0zR
2023-02-18 17:12:27 Two-thirds of people age 65+ have 2 or more comorbidities. Graph of in-hospital mortality in males by age groups. A "dose response" of comorbidities on top of age. Reduced physiological reserve a key factor. "Inflammaging" discussed. https://t.co/bbTJchkrnE
2023-02-18 17:12:26 A new and astute review of comorbidities and Covid, with attention to causality and biases https://t.co/4unhpohrbX @NatureMedicine by @clarkdrussell @ICULone @kennethbaillie Their influence varies considerably by the 3 phases of illness. #LongCovid least impacted https://t.co/RXrHVUi4LM
2023-02-18 03:20:49 Just when you think you've seen it all....... https://t.co/K9Wk0Ma2Up https://t.co/mcW6gEmNNm
2023-02-17 21:21:21 When we think of the immune system, antibodies and B &
2023-02-17 18:00:37 On a related front, the definitive review on autoimmune neurologic diseases https://t.co/nXVi8Dufx0 by @darshi_r @RussellCDale and colleagues @NatRevNeurol https://t.co/Kbo0JIyiF4
2023-02-17 16:48:00 This is the best and up-to-date paper (preprint) I've seen on transformer models, what's generating the LLM buzz in #AI now https://t.co/lVeZ1BooTA by @xamat https://t.co/y4Isg5Xf8M
2023-02-17 16:04:17 XBB.1.5 now dominant is all US regions without an uptick in hospitalizations or deaths in recent weeks https://t.co/fOz9luTlTo
2023-02-17 16:04:16 Variant https://t.co/jjl2AnOYb5 Now 80% XBB.1.5 as the variant accounting for new cases, with no other variant showing gains https://t.co/81VKDjgPLO
2023-02-17 15:27:40 Ignominy. From https://t.co/JzZFPPUbwp https://t.co/8luYZ6ExJi
2023-02-17 15:03:13 When large language models make the headlines https://t.co/MrICIzKqwT "The A.I. Isn't Ready for Humans" It's worth reading @kevinroose's full 2-hour transcript for many reasons, including conversation length has now been cut by @Bing https://t.co/dtZy8MjwL0
2023-02-17 14:51:27 From the Lancet paper, the difference in health care policy for prior Covid in the US and other countries https://t.co/VUJpaTSIrB
2023-02-17 14:51:26 A year ago I wrote about the failure of the US to acknowledge the protection afforded by prior Covid https://t.co/a7bue4mMgW
2023-02-17 00:28:58 Good summary for infection-acquired immunity. The unpredictability of a Covid infection with respect to inducing severe disease and chance of developing #LongCovid https://t.co/20YnGjtgPW
2023-02-17 00:06:34 RT @WesElyMD: 1/The Haunting Brain Science of Long COVID Here I use science to raise awareness of a growing public health nightmare hid…
2023-02-16 23:47:02 Link https://t.co/CVIyJDjF74 Graph shows comparison vs vaccination for different outcomes over time Conclusionpulls a lot of data all together Work by @IHME_UW team https://t.co/ucnoWJ0SB8
2023-02-16 23:47:01 New @TheLancet Prior Covid provided high protection vs severe disease, including Omicron BA.1 ( ~90% at 10 months post-infection), as determined by systematic review of 65 studies Protection vs reinfection was high (~78% at 10 months) until Omicron,to ~44% w/ more rapid https://t.co/DfuwoSFaW3
2023-02-16 23:12:45 Muscle biopsy in-depth assessment in people with #LongCovid w/ exercise symptoms compared with 2 control groups shows microvascular abnormalities with reduced capillaries, immune cell dysregulation, distinct gene expression signature https://t.co/ngv2vKhcLn @ChariteBerlin https://t.co/ED8OJ2zNQ2
2023-02-16 20:17:11 RT @JenSeniorNY: Can we discuss long Covid for a sec? I know: You're over it. I was too, until I got it. I'd now like to talk...etiquette.…
2023-02-16 18:09:38 Beyond an association, as established in many previous reports, evidence from Mendelian randomization that Covid can cause atrophy in specific brain regions https://t.co/NnMdcdIxuV https://t.co/IBeXhzZMFa
2023-02-16 17:05:52 A 2nd @NatureMedicine report today showing prevention of hypertrophic cardiomyopathy in mice via genome editing, reinforcing the potential of a single-dose to cure the most common genetic heart disease https://t.co/S8lqnjRyJt @davidrliu @danielreichart3 and colleagues @harvardmed https://t.co/Q4c7IJjApb
2023-02-16 16:53:39 Exciting to see genome editing of hypertrophic cardiomyopathy to correct the pathogenic variant in the humanized mouse model, laying the groundwork for a potential cure in the future https://t.co/mB4obCSMnJ @NatureMedicine @Transactivator @andreas_c_chai @UTSWNews https://t.co/6i5yvXF4jQ
2023-02-16 16:43:08 Two new prospective studies of #LongCovid --59% organ impairment at 1 year https://t.co/v1YXyYMITb -->
2023-02-16 16:29:00 A new and exceptional review of neurodegenerative diseases @CellCellPress that breaks them down to 8 hallmarks https://t.co/RymBdFZzMs https://t.co/BeWJmSbMTe
2023-02-16 15:04:21 This work to understand prefusion stabilization for RSV helped set the foundation for very rapid Covid vaccines using the 2-P (proline) substitution that stabilized the spike protein before entering cells, making it much more immunogenic.
2023-02-15 23:39:26 More background on the roll out here https://t.co/xYyfJPufCO https://t.co/ElyNtKFLih
2023-02-15 22:20:59 Why did it take so long to get these effective vaccines vs. RSV? It took structure-based design to stabilize the prefusion protein, as shown below, and nicely explained by @BarneyGrahamMD https://t.co/SDxXuKSjIs https://t.co/WuIGN5qbQB
2023-02-15 22:19:15 Another RSV vaccine much larger randomized trial (also of 1 dose) with very high efficacy in people age 60+ https://t.co/SuyAu9Dxby https://t.co/1014036Bbe
2023-02-15 22:06:56 The RSV virus was discovered in 1956 and sequenced in 1982. Only now do we have effective vaccines. Today @NEJM results for age 65+ randomized trial https://t.co/SuyAu9E516 https://t.co/HloAhDADV2
2023-02-15 19:10:01 Link @ScienceTM https://t.co/mxwylkjo6H Nice #AI work by @NimaAghaeepour and colleagues @Stanford to predict newborn outcomes @StanfordPeds @StanfordPain @StanfordOBGYN https://t.co/iCarPFNaYt
2023-02-15 19:10:00 "Using 2 cohorts w/ a total of 27,000 mothers linked to more than 32,000 neonates, and validated externally with more than 12,000 newborns, we demonstrated the ability to serially and comprehensively predict neonatal outcomes from various maternal conditions extracted from EHRs." https://t.co/KH80B8YUNe
2023-02-15 16:11:14 Delay of onset of other autoimmune diseases in small randomized, placebo-controlled trials for people at high risk Multiple sclerosis https://t.co/IyNTODFgxu Rheumatoid arthritis https://t.co/5es4J6jYEY https://t.co/qjV6NOlgCJ
2023-02-15 14:37:52 The first disease-modifying drug for autoimmune, Type 1 diabetes, to forestall its onset, represents a big first step towards preventing such conditions from ever manifesting https://t.co/YnRUdOPtrg @Nature @ElieDolgin https://t.co/H4umWEnJKV
2023-02-15 05:20:24 RT @BenLGreenberg: @EricTopol @doximity Thank you Dr. Topol! So proud of DocsGPT - Conceived and built by @doximity folks far more talente…
2023-02-15 01:46:18 It isn't taking long for #ChatGPT and large language models #AI to help physicians deal with insurance companies! @BenLGreenberg and team @doximity is all over it https://t.co/hRxorApIB8 https://t.co/9gruAX3Utz
2023-02-15 00:33:37 https://t.co/264pbVKK3C
2023-02-14 23:51:55 Succinct full text reviews the different underpinnings, the unmet needs (a lab test, distinct subtypes, validated treatments) and recognition of patient led research https://t.co/rgfhCJmz13
2023-02-14 23:43:42 Towards a deeper understanding of #LongCovid by @VirusesImmunity and @PutrinoLab https://t.co/NwXVISGlNd @TheLancetInfDis https://t.co/sYgUQapfEm
2023-02-14 20:13:58 The difference in T cell response for autoimmune conditions, response to infection, and cancer. From a new review @ImmunityCP https://t.co/QYeqcBIQsP by @Dr_ImmunoMan_D @AnaAndersonlab https://t.co/nxpYzIN0CA
2023-02-14 20:00:09 The article features @UCLAHealth's #LongCovid Clinic, with a section here on POTS https://t.co/IRnQgcQFg5 https://t.co/TNLZ3Kyt37
2023-02-14 16:53:14 A new study @CedarsSinai with association of higher diabetes risk after Covid (adjusted odds ratio 1.58) and reduction with vaccination https://t.co/7poBVuKzOx @JAMANetworkOpen https://t.co/RTmz6B1zmY
2023-02-14 14:46:59 Neurologic sequelae of #LongCovid https://t.co/aceRT1teZd @sciam by @SutherlandPhD https://t.co/mmqTdhFSVe
2023-02-14 01:47:49 RT @jonirutter: Thanks @EricTopol for highlighting this important piece by @AmyDMarcus w/ @LisaAMcCorkell. Some resources to help are here…
2023-02-14 01:12:59 RT @TCLawry: A great read (as always) from Eric Topol MD on the need to pull forward the Hospital-at-Home movement. @EricTopol #HaH #hos…
2023-02-14 00:06:31 New Ontario, Canada report of Paxlovid effectiveness shows 44% reduction of hospitalizations, 51% reduction of deaths (point estimates) without being significantly affected by age (67% age 70+) or vaccination status https://t.co/b3AQq8tmax @CMAJ https://t.co/3xej0K2xIm
2023-02-13 23:55:15 Accompanying editorial https://t.co/FUguodHuql "Given that no association was found between oral antiviral treatment and viral burden rebound ... emphasizes the importance of continuing to offer antivirals to individuals with COVID-19 who are at increased risk of progression.." https://t.co/8VwcVU9XgZ
2023-02-13 23:49:22 Lack of evidence of overall Paxlovid viral or clinical rebound in a hospitalized cohort, with subgroups identified at higher or reduced risk https://t.co/lNcuVBLzAb @CarlosWongHKU @bencowling88 @gmleunghku @TheLancetInfDis https://t.co/IsPpKzAnw0
2023-02-13 22:16:54 A long held general perception is that adults with type 1 diabetes tend not to be overweight. A new @AnnalsofIM publication of a national sample challenges that view https://t.co/J9zA25dQwj @JohnsHopkinsSPH https://t.co/1Pr0vgoLJD
2023-02-13 16:18:47 Real-time, 3D tracking of the gastrointestinal tract via a wireless ingestible microdevice https://t.co/gcJ8qF1APH @NatureElectron @Caltech tested in large animal models https://t.co/M04vwrU96P
2023-02-13 15:55:39 The pandemic provided an unprecedented incentive in the US for hospital-at-home reimbursement by Medicare. Now what? https://t.co/W95yJBsFGp https://t.co/TmTbBo47YL
2023-02-12 18:22:42 The 1st survey to assess public views of polygenic testing of embryos before implantation (commercially available in the US without data to supports it use) had surprising results @ScienceMagazine this week Excellent explainer thread below, by the report's first author https://t.co/uDbhhUbgee https://t.co/Lk5VM1pdb0
2023-02-12 17:49:43 @danielalamasmd "....this staggering scientific advance has left them facing existential questions." https://t.co/tc9aVZ8rcN
2023-02-12 15:47:03 I wrote about the Hospital-at-Home movement https://t.co/W95yJBsFGp
2023-02-11 17:36:52 @AditGinde The sensitivity analyses (as commented by the editorialists) you did to understand the missingness in test date are important. Since there are innumerable critics of the day 0 imbalance, it would be great for you to lay this out in a thread https://t.co/BQy1MOca51
2023-02-11 16:08:44 Accompanying editorial https://t.co/vsJPj094Uc by @CarlosWongHKU and @gmleunghku For those brilliant critics of the day 0 effect, read the paper https://t.co/DH8U6dd7cn
2023-02-11 15:56:04 A review of 68 vaccine effectiveness studies: Preserved protection vs hospitalizations and deaths out to 6 months, substantial waning vs infections, especially Omicron
2023-02-11 15:45:50 As we're seeing w/ #LongCovid, it's essential for researchers to work closely with patients to make progress, democratizing medical science https://t.co/LmKqgH723V by @AmyDMarcus w/ @LisaAMcCorkell @patientled "We consider patients as researchers"— @jonirutter @ncats_nih_gov https://t.co/Jdd9VGPH0S
2023-02-11 15:16:52 A new #LongCovid deep assessment of the immune response confirms dysregulation, exhausted CD8+ T cells, uncoordinated humoral-cell arms https://t.co/hIIoSyajeK @GladstoneInst @UCSFMedicine Previous report https://t.co/jFbxvgWLUP @VirusesImmunity @PutrinoLab https://t.co/prZuUlBLWA
2023-02-11 01:07:42 RT @agingdoc1: When M.D. is a Machine Doctor Helping medical doctors and patients in the Foundation Model A.I. era Excellent discussion b…
2023-02-11 00:22:25 @AstroKatie @TheLancetInfDis It's very unusual for any drug to do better in the real world (via effectiveness studies) than in randomized, placebo-controlled clinical trials. Now that we've seen this broad benefit replicated multiple times, I'd say yes (made available)
2023-02-11 00:11:22 Very low rate of clinical relapse (aka rebound) "Using emergency department visits as a surrogate for clinically significant relapse ...., we observed a *lower* ED visit rate in patients treated with nirmatrelvir–ritonavir [3.9%] compared with untreated patients [4.7%]"
2023-02-11 00:06:06 A new real-world effectiveness study documents 85% reduction of deaths and 55% reduction of hospitalizations for Paxlovid, independent of vaccination status, age, variants https://t.co/9Hu7W6NPs3 @TheLancetInfDis https://t.co/D7TGUvPCYf
2023-02-10 20:43:27 @kyle_carm Community levels (below), a formula defined by the CDC website, are different from transmission https://t.co/6ZN3NXbhwW
2023-02-10 20:30:05 RT @NSpottiswoodeMD: What a delight to talk about unbiased diagnostics and amoebic brain infections with the awesome @ronwinslow at the @WS…
2023-02-10 19:40:01 Community transmission data by county is improving but still relatively high, so don't let your guard down https://t.co/WrhEyCPXkF https://t.co/InuBEkxloM
2023-02-10 19:34:49 "Metagenomics is the future of medical diagnostics. It should be the present, but not many hospitals are equipped to do it." https://t.co/bi8eExQbxX @UCSFHospitals @UCSFMedicine by @ronwinslow More here (A Culture of Cultures): https://t.co/Y8eZSBt3dQ https://t.co/LsyGgUl2d3
2023-02-10 17:57:31 RT @hholdenthorp: My column that builds on the great editorial from Shirley Malcom and @sudipsparikh about graduate student and postdoc sal…
2023-02-10 16:59:02 Some common underpinnings of #LongCovid with multisytem inflammatory syndrome in children (MISC-C) https://t.co/gdgV4JoNOL Persistent virus/remnants, dysregulated immune cell activation, multisystem involvement, autoantibodies, delayed response @ScienceMagazine by @BrodinPetter https://t.co/G0HEm5FJnl
2023-02-10 15:48:10 Outside the Northeast region during XBB.1.5's rise, there was no surge in hospitalizations, now below 30,000 nationally. Deaths have come down from ~500/day, but still alarmingly high with a substantial proportion preventable https://t.co/1gAUEnzRZQ
2023-02-10 15:37:37 All regions are XBB.1.5 dominant except the Northwest https://t.co/hl2s2kN6kT
2023-02-10 15:37:36 The XBB.1.5 variant now accounts for ~75% of new cases in the United States, with no other variant showing gains (including CH.1.1) https://t.co/jjl2AnOYb5 https://t.co/PpqPgz8atN
2023-02-09 21:06:14 Discovery of a new receptor for the #SARSCoV2 spike protein (LRRC15) that binds to the virus like molecular Velcro https://t.co/D8WbwEvjGp @PLOSBiology @Neely_Lab @LLTheResearcher @Sydney_Uni and colleagues
2023-02-09 19:27:23 Accompanying editorial pointing out the flaws in medical education https://t.co/teVQigZtT4 https://t.co/GEi7cePwQv
2023-02-09 19:14:53 When #ChatGPT performs at the passing threshold for the US medical licensing exam (USLME) https://t.co/6ct6fbOujI @PLOSDigiHealth I wrote about the implications https://t.co/2Axg5C4HtT https://t.co/XquPMjXtNu
2023-02-09 18:04:01 New @CDCMMWR reviews the data above, age 12+ https://t.co/03bkAOmvh4 https://t.co/D7QbJi15IX
2023-02-09 17:03:21 An inhaled hydrogel shield coats the airway to prevent Covid infections, yet another way to get ahead of this virus, no less other respiratory pathogens https://t.co/UhWJ61IFEi @NatureMaterials https://t.co/E9q8ZsYf8t
2023-02-09 16:48:05 Long term caloric restriction: a small effect on biologic aging, as assessed via DNA methylation markers in a randomized trial of healthy adults @NatureAging https://t.co/OBBmA3RRu3 https://t.co/M9ebUU5v1n
2023-02-09 15:51:31 RT @Dakota_150: Osterholm Update: "Episode 124: Taking Long COVID Seriously" https://t.co/rJZK3LocYA
2023-02-09 14:57:38 “The pandemic after the pandemic” Today’s @washingtonpost editorial on #LongCovid https://t.co/8gjEK16dao
2023-02-09 14:35:34 RT @EricTopol: Interferon λ, a new way to cut hospitalizations by 50% after Covid, in a randomized, placebo-controlled trial >
2023-02-09 03:03:09 It is frankly pathetic that this treatment will unlikely be available in the US, based on FDA regulatory and financial issues https://t.co/GzTIylaxam @benjmueller “I don’t know of any virus that can navigate a cell where interferon got there first”--@virusninja https://t.co/19lTWBKWUs
2023-02-09 01:23:53 It took over an hour to post this thread when Twitter was down and I almost gave up. But persisted because I think it’s quite a significant finding that broadens our potential (currently very limited) out-patient treatments
2023-02-09 00:02:15 Why are doctors so polarized about Covid treatments (HCQ, ivermectin, vaccines)? https://t.co/WaBCVuGe3Y "The preference for @FoxNews is a significant predictor of 8 outcomes (controlling for political ideology)" "Political ideology colors the evaluation of scientific evidence" https://t.co/VYECDMsvFx
2023-02-08 23:49:19 New @bmj_latest Protection for newborns/infants by maternal vaccination https://t.co/lkFaPRLiTY https://t.co/puT8gu1KwS
2023-02-08 23:00:38 And as seen here and in the new trial report, viral clearance was accelerated https://t.co/9izufULZ2I
2023-02-08 22:56:01 A single dose injected under the skin No increase in adverse events cf placebo Some key data summary points below https://t.co/YY0dYVqbfg
2023-02-08 22:56:00 Consistent across pre-specified subgroups, notably vaccinated (84%) and the unvaccinated https://t.co/Bovuyn71hq
2023-02-08 22:53:08 Consistent impact across variants, ~50% Omicron https://t.co/tc1MVhEvlO
2023-02-08 22:53:07 Interferon λ, a new way to cut hospitalizations by 50% after Covid, in a randomized, placebo-controlled trial >
2023-02-08 20:19:50 I was disappointed and surprised by the lack of mention of #LongCovid during last night's SOTU https://t.co/l5X0T8MaCU https://t.co/9dNC8iUx8b
2023-02-08 20:11:07 @_Eric_Reinhart @nytopinion @NewYorker Much appreciated, Eric. Your oped was so powerful, folding in the last few years of Covid, and deeply reinforcing the need for universal healthcare. If only we could use our collective power, as you aptly put it, to achieve the changes so desperately needed
2023-02-08 19:25:47 "Doctors can no longer be passive witnesses to these harms." Common threads for this important @nytopinion essay https://t.co/r31vUIC0GR by @_Eric_Reinhart and a piece I wrote a few years back https://t.co/XrEHsIjDQd @NewYorker https://t.co/kJPtWJpmuG
2023-02-08 17:25:20 Abnormalities of the gut microbiome in myalgic encephalomyelitis #MECFS in 2 cohorts and controls https://t.co/1mVV4RuB9W @cellhostmicrobe implications for #LongCovid too https://t.co/ZjvWWINRdX
2023-02-08 17:13:50 The search for missing heritability and a new report of ~400,000 exomes on rare/ultrarare coding variants https://t.co/39BWeJDdOG Rare variants contribute relatively little at pop level @Luke0connor @broadinstitute @danweiner92 @NadigAjay @nature https://t.co/sSPduscYRa https://t.co/SSgYVqSm74
2023-02-08 16:57:06 Agree with @JoannaStern "A big change is coming to how we get information and how we interact with our computers." https://t.co/kbsj8hVEwv @Microsoft @bingc #ChatGPT https://t.co/R6ygqmTsVo
2023-02-08 15:58:27 I discussed #AI (including LLMs) and the future of healthcare with @RobertPearlMD in the latest @FixingHCPodcast https://t.co/jaaJl0Ei6V https://t.co/Wewm3agczO
2023-02-08 15:50:02 Good news that there are no new #SARSCoV2 variants detected in China to date: @TheLancet report from ~3000 sequences (mainly BF.7 and BA5.2). Just from Beijing, thru 2022, and only a snapshot, so genomic surveillance is a work in progress https://t.co/cw7jkH5yP0 https://t.co/hLDt5UtWrh
2023-02-07 23:56:05 @JusDayDa @Microsoft @bing @CadeMetz @KYWeise Yes, I wrote about that https://t.co/2Axg5C4HtT
2023-02-07 23:17:23 Bingo for @Microsoft's new #ChatGPT powered @bing today https://t.co/LnoGJJwykQ @CadeMetz @KYWeise https://t.co/PwD9Zu0XVk
2023-02-07 22:51:38 In 2020, @ConsumerReports's investigative work showed @GoodRx was sharing medication data to tech companies w/o user permission https://t.co/qFq10QZe4o That was just the beginning->
2023-02-07 18:42:09 —I'd like to accurately sequence DNA and epigenetic modifications simultaneously —No problem, here you go —Are you kidding? —No https://t.co/cB6cBk8Xpo @NatureBiotech @Joanna_Holbrook @CEGX_news @walraj @paidicreed @ChemCambridge @Cambridge_Uni https://t.co/eO54Ecl5vp
2023-02-07 18:15:45 One end of the LLM user spectrum from @Nature link above re: @haffi67 https://t.co/TE8fQDvU0w
2023-02-07 16:59:13 The term "generative #AI" may be appropriate since #ChatGPT and LLMs are generating a helluva lot of biomedical articles https://t.co/iQJHM1lpri @stokel @Richvn @Nature https://t.co/TmGh593Sgr @KyleLam93 @LancetDigitalH https://t.co/jaLw2gp4So https://t.co/0LdLIm4S6t
2023-02-07 16:29:20 Good to see the first #AI randomized controlled trial for enhanced chest X-ray detection of lung nodules in screening >
2023-02-07 16:14:42 Direct-to-consumer drug ads: the less a drug's clinical effect, the more spent by the drug companies https://t.co/vaR3VTUyQd @JAMA_current They should be banned. And so should "further research is needed" in the conclusion. https://t.co/NXL6fh7YEL
2023-02-07 16:00:14 Spotlight on pacing for #LongCovid and #MECFS in today's @PostHealthSci by @AmandaMoMorris https://t.co/jTE6rmX7gR https://t.co/SErWfhXeep
2023-02-07 15:50:45 Reviews the biology known about IgG4, difference seen with adenovirus vector vaccines. Conclusion highlighted below https://t.co/z26fZzHryc
2023-02-07 15:35:50 A tour de force review on engineering T cells https://t.co/N9BgKZPsud by @lenghan_bioinfo @JingwenYang_ @yingjing06 @GreenLymphoLab @_meimeimei_ @MDAndersonNews that adds much to my recent review of this exciting field https://t.co/2m7WF34Pj3 https://t.co/OwZDZa1vCk
2023-02-07 15:21:44 New @SciImmunology Getting the IgG4 story right (after mRNA vaccines) https://t.co/VhgLLgb6up by @ShivPillai4 @ragoninstitute "Is it bad, good, or is IgG4 just misunderstood?" https://t.co/VnO09TOrNa https://t.co/27IkIntIc1
2023-02-07 02:47:00 RT @danielalamasmd: Imagine if your life expectancy increased by decades within your own lifespan. That’s the story for cystic fibrosis rig…
2023-02-07 02:27:25 RT @DanielCohrsMD: Great article + thread on #LongCovid and the innovative review paper below, written as a collaboration between patients…
2023-02-07 00:20:26 We had the real privilege of having @pearsekeane, @ucl Prof of Artificial Medical Intelligence, as our @ScrippsRTI visiting professor today https://t.co/odHJlYLIBx
2023-02-07 00:03:57 Vitamin D may reduce the risk of developing Type 2 diabetes in people deemed pre-diabetic, combining 3 randomized, placebo-controlled trials with a modest effect https://t.co/3hYOVKUQWH @AnnalsofIM https://t.co/opbeuZcx2L
2023-02-06 23:50:47 RT @VirusesImmunity: A team member working on our #PrimeandSpike nasal spray COVID booster vaccine developed #longCOVID Long COVID is a…
2023-02-06 18:48:58 More on this report linking the APOE gene with gut microbiome-brain communication https://t.co/hkWNHdTmck @Nature @Alfonso_525 @UFNeuroscience @UFMBI https://t.co/zvNyxYhez0
2023-02-06 17:23:02 RT @WesElyMD: 25/ fin Read the most well-researched review on Long COVID to date @ahandvanish &
2023-02-06 16:26:11 Based on nationwide screening in Iceland, the prevalence of smoldering multiple myeloma (precursor to MM, no symptoms) is higher than expected and has implications for early treatment https://t.co/ozVoIhzqj2 @NatureMedicine https://t.co/tqBRuHS2LX
2023-02-06 16:18:54 A study today purports a healthy lifestyle before Covid was associated with reduced risk of #LongCovid. That doesn't align with my experience at all—that affected individuals were remarkably health conscious and fit https://t.co/zYAnqeihUu @JAMAInternalMed https://t.co/IY1H9Fprs9
2023-02-06 16:08:56 Excess mortality among American physicians during the Covid pandemic https://t.co/fGHu44FE9R "Active physicians had lower excess mortality than nonactive physicians despite their higher risk " @JAMAInternalMed https://t.co/gMEhQ2ibRc
2023-02-05 19:21:17 RT @euanashley: A landmark study. Adverse drug outcomes significantly lower in those with pharmacogenomically-guided therapy. It is time…
2023-02-05 17:32:40 Twitter, by @stephanpastis https://t.co/ex5JhfeZGu
2023-02-05 17:24:07 Good graphic and essay for delineating the mechanism of tirzepatide (Mounjaro), a potent anti-obesity drug "that rivals the efficacy of bariatric surgery" https://t.co/A0WNI0yR62 @jclinicalinvest An important topic that I recently reviewed https://t.co/SMZO20WGRs https://t.co/ouLG6obbgI
2023-02-04 17:51:45 Rare genetic disorders in the interferon pathway and life-threatening Covid https://t.co/Mn2XZ8Bjnb @jclinicalinvest by @casanova_lab and @MAndersonUCSF https://t.co/wjZIVTzBo3
2023-02-04 17:13:08 Two studies from leading labs characterized XBB.1.5 this week. We're very fortunate that the rise of this variant to dominance in the US was not accompanied by worse outcomes https://t.co/4y0WxqCzbe @SystemsVirology https://t.co/BcoiR7MItP @yunlong_cao @TheLancetInfDis https://t.co/ztUMayhP6w
2023-02-04 16:58:31 How can #AI help improve outcomes for lung cancer, the leading cause of cancer mortality worldwide? An outstanding review https://t.co/lSRW7kUDgU @CellRepMed @ColtonLadbury @DrAryaAmini @DrRaviSalgia @cityofhope https://t.co/wS7n8XWblH
2023-02-04 16:43:35 A bit of irony "It turns out #ChatGPT is quite bad at math" https://t.co/gmR7JGo8IC @JoshZumbrun https://t.co/ImexjxNyZu
2023-02-03 23:27:55 RT @inthebubblepod: What chronic symptoms and health risks are most common in those with #LongCovid ? @EricTopol tells @ASlavitt they can r…
2023-02-03 18:07:39 Differentiate from #AI, humans spot on, by @nytdavidbrooks https://t.co/rstp6eytdS (the premise of #DeepMedicine, too) https://t.co/zwOebyJSY9
2023-02-03 16:51:47 Insightful on #ChatGPT, LLMs for science "Soon this technology will evolve to the point that it can design experiments, write and complete manuscripts, conduct peer review and support editorial decisions to accept or reject manuscripts." https://t.co/u1Gj9Ln1h3 @Nature https://t.co/ZZJzCS7aNO
2023-02-03 15:53:53 The XBB.1.5 variant now accounts for ~66% of new cases in the US, up only ~5% from last week. https://t.co/jjl2AnOYb5 CH.1.1 still low at 1.6%. No other variants gaining at an appreciable level https://t.co/PfgVZMv7xj
2023-02-03 15:46:58 My conversation with @ASlavitt on #LongCovid and getting ahead of the virus https://t.co/tuQh6rktOj @inthebubblepod Regarding our recent review https://t.co/EgO7gtFvoe @ahandvanish @LisaAMcCorkell @julialmv @NatureRevMicro
2023-02-03 14:35:32 New and succinct review of postural orthostatic tachycardia syndrome (POTS) and autonomic dysfunction post-acute Covid https://t.co/Y6NHGkKTHV #LongCovid @ArturFedorowski @NatRevCardiol https://t.co/oEOGU4EmQV
2023-02-02 23:57:02 Dignity-based medicine "Respecting the dignity of the patient as a knower suggests that expertise should also include the expertise of patients—on their body, their experience of pain or joy, and how they weight the risk of harm against benefit" https://t.co/UgyNum3j5q https://t.co/PDwoBMw6wR
2023-02-02 23:20:24 The promise for T-cell therapies has jumped from their success in refractory blood cancers to approaching solid tumors, autoimmune conditions, and anti-scarring, along with many new ways to engineer the cells https://t.co/2m7WF34Pj3 https://t.co/NX6vPfmJ18
2023-02-02 18:08:30 New CDC report on bivalent booster protection vs XBB.1.5 variant infections https://t.co/DXz5pVEbg5 https://t.co/0uo1kHpYFR
2023-02-02 16:13:07 Good new rundown on bivalent booster benefit https://t.co/mGmGjb0e3s by @SmithDanaG @NYTHealth https://t.co/s4Cofcsxsk
2023-02-02 15:13:52 @PeacockFlu @LongDesertTrain Right, thanks to Ryan. And your new report culminating in this https://t.co/RzxY7Xdv92
2023-02-02 04:05:22 RT @EricTopol: The future of Covid vaccines that we need now, a new feature @Nature by @ewencallaway, including nasal, for mucosal immunity…
2023-02-02 00:19:23 A terrific new review of our innate immunity @NEJM today, with relevance to #SARSCoV2 and Covid https://t.co/xpEMyzmgKK https://t.co/0kQW9y6bPg
2023-02-01 20:51:49 RT @ScrippsRTI: Immunocompromised people are increasingly on their own when it comes to protecting themselves against COVID-19. @EricTopol…
2023-02-01 19:56:16 Ready for a smart toilet? https://t.co/agsdJb2kqx @ScienceTM I'm not. But it could be a good research tool for data collection for willing participants https://t.co/zkyfxJMbLw
2023-02-01 18:07:26 This was the "Dream Vaccine" exceptional @Sciencemagazine article by @sciencecohen nearly 2 years ago. Next generation vaccines are not a dream—they could have been a reality by now https://t.co/K7D2L3hNbY https://t.co/2btmXVGFZr
2023-02-01 17:59:06 RT @WHCOS: As COVID cases rose in Dec/Jan, ICUs were not crushed this time? Why? The world-leading @WHCOVIDResponse plan to make paxlovid…
2023-02-01 17:28:14 See @loganawalsh's explainer thread and congratulation to this @mcgillu team for both seminal papers! https://t.co/52549BKbwc
2023-02-01 17:24:48 One of the hottest fields is biomedicine is spatial resolution of #cancer via millions of single-cell mapping + #AI. Elucidating pathobiology and better ways to Rx 2 papers @Nature today on the brain and lung https://t.co/NfCCORa0ak https://t.co/tfQqaeMPY5 https://t.co/SSZ0J8bddm
2023-02-01 16:48:19 @ahmkep Here's the rest of the article https://t.co/uYHAUfhikC
2023-02-01 16:40:23 How the time of day may affect cancer treatment https://t.co/i7ur2E83df @Nature @NatureNV https://t.co/raKvPEQwUt
2023-02-01 15:20:35 RT @Medscape: .@EricTopol and @cuttingforstone chat with the UK's professor @FryRsquared about taking risks and asking the right questions.…
2023-02-01 14:43:20 For nasal vaccines we got the first results from a large, randomized trial yesterday which were encouraging for inducing better immunity and less side-effects vs shots https://t.co/ufxF2r04wQ https://t.co/P28GNuXW0G
2023-02-01 14:27:55 The future of Covid vaccines that we need now, a new feature @Nature by @ewencallaway, including nasal, for mucosal immunity, and universal, more durable, variant-proof ones with less side effects https://t.co/9U5xO2Ve1B https://t.co/Mb8mHtDSVW
2023-02-01 01:53:38 An African lion in a zoo, deer reservoir, #SARSCoV2 probable transmission and spillover, respectively https://t.co/kcoJx00UUd @PNASNews https://t.co/Lf9JpLyClJ https://t.co/c3iBod1GBA
2023-02-01 00:55:58 RT @EricTopol: The 1st results for the @BharatBiotech nasal vaccine (BBV154, approved in India) randomized trial vs shots now posted, super…
2023-01-31 19:29:00 Accompanying text https://t.co/Sxf34WhrD4
2023-01-31 19:19:53 A good diagram by @daniella_raz @TheEconomist Example: —95% of Americans age 65+ have had at least 2-shots —Most Covid deaths are in people age 65+ who are vaccinated —There's still ~90% reduction of death for vaccinated vs unvaccinated https://t.co/oq3jBYkNly
2023-01-31 18:35:29 2. Pharmacists unwilling to prescribe Paxlovid, even though empowered (these are results from new @Medscape survey) 3. Dr. Jha is a champion for developing nasal and universal coronavirus vaccines and explains why it hasn't happened (yet)
2023-01-31 18:35:28 My interview with @AshishKJha46, leader of the @WHCOVIDResponse, about the pandemic We covered many important issues https://t.co/dzSNMOCQRH 1. Underuse of Paxlovid in older patients: not backed up by low incidence of rebound and ease of sidestepping potential drug interactions
2023-01-31 17:53:18 RT @JamesSurowiecki: An effective nasal vaccine for Covid would be exceptionally valuable.
2023-01-31 17:20:49 @YaleSPH @kmpanthagani @meganranney Terrific news. Congrats Megan!
2023-01-31 17:08:27 @AstroKatie @BharatBiotech There are no head-to-head trials of mRNA vs Covaxin so hard to know, different populations and tracking of outcomes. Data posted is for immune response and side effects only
2023-01-31 17:01:38 T and B cell responses for nasal vaccine (2 doses) vs Covaxin shots (2 doses) https://t.co/NBQ84Fgs2Y
2023-01-31 16:58:18 The 1st results for the @BharatBiotech nasal vaccine (BBV154, approved in India) randomized trial vs shots now posted, superior antibody and cellular immune response (vs ancestral and Omicron)
2023-01-31 16:41:00 And now the @JAMA_current editors weigh in https://t.co/qXaZNQ4oKU @AFlanagin @KBibbinsDomingo https://t.co/GMNk6qYrvu
2023-01-31 16:31:05 The CDC quietly posts these data on their website (Jan 25th latest installment) which counters the myth that only people age 65+ derive survival benefit from boosters. There is nothing magical about a particular age cutoff-—it's a subgroup analysis used to support one's beliefs
2023-01-31 16:24:58 The #AI machine vision kicks in for the gastroenterologist late in the day when fatigue sets in: nearly 4-fold better performance for polyp detection in randomized trials https://t.co/eb1jhDkZMA @JAMANetworkOpen https://t.co/HNGm2Tfq2D
2023-01-31 16:00:12 The underused Covid treatment https://t.co/XcvEFol8A4 by @germanrlopez Significant reasons, as verified by the new @Medscape survey, are the exaggerated concerns about drug interactions and rebound not backed up by data
2023-01-31 15:00:05 More on the link between persistent infections and #LongCovid Among 381 infections lasting 30+ days, a 50% higher rate compared with infected controls https://t.co/MyUcgwIEvV
2023-01-31 13:59:46 Only high-income country without universal healthcare coverage https://t.co/Lmc6ULjHkZ
2023-01-31 13:59:45 Worst maternal and infant mortality https://t.co/NsUN0pQ6zK
2023-01-31 13:59:44 Highest death rate from Covid https://t.co/1QR82VHC6Y
2023-01-31 13:59:42 With highest spending https://t.co/EyofQqhDJu
2023-01-31 13:59:41 The United States, the perennial outlier when it comes to healthcare spending and outcomes New data through 2021 vs peer countries by @commonwealthfnd https://t.co/qa9q75IEJB Worst @OECD life expectancy https://t.co/2tBkW9b7SH
2023-01-31 03:27:19 “I don’t think that the conventional cardiac surgeon, as we know him, will exist in a few years’ time” https://t.co/EkOEoBuczZ by @simonakam H/T @herbgreenberg https://t.co/A2AoWtcUYB
2023-01-30 23:52:43 Immune imprinting of #SARSCoV2 and its potential benefits https://t.co/ze970tAN99 @TheLancetInfDis by @CiesekSandra @SebastianHoehl https://t.co/jU6rYu2kyv
2023-01-30 23:28:38 Updated @CDCgov data on bivalent booster, age groups and deaths Overall 91% reduction of deaths across all age groups vs unvaccinated, less (80%) without bivalent booster The absolute reduction increases w/ age
2023-01-30 18:49:41 Innovation in cancer vaccines to markedly increase cancer antigen-specific T cells and activation of these cells @natBME @CHADNANO @DrMTeplensky @MirkinGroupNU @NUFeinbergMed @IINanoNU https://t.co/rLXCM7OI4r https://t.co/HEFCqldgqd
2023-01-30 18:17:49 RT @mehdirhasan: It’s mild! It’s like the flu! It doesn’t affect kids!
2023-01-30 16:43:01 fixed link https://t.co/5FV3Gn0tUw
2023-01-30 16:40:15 New support for autoimmunity as a component for triggering atherosclerosis via CD4+ T cells https://t.co/d5EI71E8gV @mariedepuydt @UniLeidenNews https://t.co/LpjCBSMoNV
2023-01-30 16:10:37 From an analysis of 42 studies in 15 countries, "students lost out on about 35% of a normal school year's worth of learning" during the Covid pandemic https://t.co/yYm4nLNTob @NatureHumBehav https://t.co/iUMwWDjDEY
2023-01-30 16:03:45 "In this study, COVID-19 was a leading cause of death among individuals aged 0 to 19 years in the US." @JAMANetworkOpen https://t.co/AWawqJ0KLl by @flaxter and colleagues https://t.co/BIokfnMDez
2023-01-30 15:06:07 @hholdenthorp @DukeMedSchool @DavidJSkorton @AAMCtoday @Bob_Wachter It’s amazing it took this long for med schools and universities to stand up
2023-01-30 14:33:37 Some years ago, owing to the formidable and practical challenges, I thought the chance for T cell therapy to make a difference would be minimal. That's changing. https://t.co/2m7WF34Pj3
2023-01-30 01:00:00 CAFIAC FIX
2023-01-17 00:05:50 Mapping XBB.1's antigenic distance (among others): "We observed that human post-vaccination neutralisation titres reflected the antigenic map, as the largest reduction in neutralising titres compared with the D614G variant" https://t.co/epa5txNqqw @LancetMicrobe @bart_haagmans https://t.co/oEIeUKt8HR
2023-01-16 21:20:11 "I would advocate *not* moving fast and breaking things." —@demishassabis https://t.co/lvGrs8mwVl @TIME @billyperrigo on LLMs
2023-01-16 20:35:54 Important work andby @SystemsVirology to characterize the XBB.1.5 variant. Fortunately, our immunity wall in the US is helping to blunt its impact to be much less than Omicron BA.1. Could be even less w/uptake of bivalent vaccines and mitigation https://t.co/mnaA3kemLp https://t.co/XRU6WCgsiW
2023-01-16 18:40:55 @VirusesImmunity @ahandvanish @LisaAMcCorkell @juliamv Thanks Akiko!
2023-01-16 18:40:43 RT @VirusesImmunity: Amazing, timely, comprehensive, and evidence-based review - Long COVID: major findings, mechanisms and recommendations…
2023-01-16 17:58:54 If you're not keeping up on the disruptive power of #AI chatbots, you might want to read these from today https://t.co/DFTGcMFTaq @NathanSanders_ @schneierblog @BKCHarvard @nytopinion https://t.co/dFjsgjYwGA @KalleyHuang https://t.co/X9FyYh2IyH
2023-01-16 17:33:35 We keep ignoring somatic mutations in the blood (CHIP) as an important risk factor for atherosclerotic cardiovascular disease, cancer, and all-cause mortality. Now a mechanistic underpinning: TP53, damage repair genes, unraveled @NatureCVR https://t.co/XttD6KynW4 https://t.co/5Oh5WUMCN6
2023-01-16 17:18:09 @terrigriffith @SFUBeedie That was the intent. Many thanks!
2023-01-16 17:13:38 Just published @NatureMedicine An astute take on the future of clinical trials and evidence-based medicine, in the digital and #AI era, by @VivekSubbiah https://t.co/625WIwa6Qx https://t.co/cLpfZKAiMI
2023-01-16 15:53:04 I review the transformative potential of #AI in medicine, now in the era of LLM/Foundation Models, in this new post, with the links to the above exams and much more https://t.co/2Axg5C4HtT
2023-01-16 15:53:03 3. US, 2022, the large language model (LLM) Med-PaLM takes the US medical licensing exam. A huge (33% relative) jump in accuracy of answering medical questions: 92.6% doctors say the AI was correct vs 92.9% other doctors were correct. Now replicated by ChatGPT. https://t.co/16itDiq3LF
2023-01-16 15:53:02 The #AI takes the medicine qualifying exam. Three to take note: 1. China, 2017, Xiaoyi passed the licensing exam with a score of 456 (passing 360-600) based on memorization and information recall, with poor performance on patient cases https://t.co/Aq3fuDiOBP
2023-01-16 14:38:38 For more on pacing (top row of the Table), a very good piece by @AmandaMoMorris today @PostHealthSci https://t.co/jTE6rmXF6p
2023-01-16 01:50:44 @Mon4Kooyong Thanks and agree on the sure fire way to prevent #LongCovid
2023-01-15 19:44:42 You've been hearing a lot about ChatGPT, DALL-E, Stable Diffusion and other foundation #AI models (also known as Large Language Models or Generative AI) lately. How are they beginning to impact medicine and healthcare? https://t.co/2Axg5C4HtT
2023-01-15 18:36:02 Sorry, I gave the wrong twitter handle for my @ScrippsRTI colleague, @julialmv. That gives me a chance to note she is currently leading this important research project to help immunocompromised individuals https://t.co/cJb7tBzJGs
2023-01-15 18:30:31 Foundation #AI goes to the movies "A.I. could create in minutes what a filmmaker worked on for years" https://t.co/Af4aU6MOg9 by @frankpavich https://t.co/ISUVLIgw7U
2023-01-15 18:26:18 It is sad to see that things have gotten worse in Japan, with fatalities towering above its prior waves https://t.co/4GVLATIav4 https://t.co/4lccBLVoky
2023-01-15 00:58:46 RT @doctorasadkhan: This is THE #LongCovid paper. Comprehensive yet accessible, jam packed with everything you need to know. Science 1-psyc…
2023-01-14 22:58:51 An excellent review of the challenges surrounding highly effective and durable nasal vaccines to achieve mucosal immunity vs respiratory viruses (including #SARSCoV2) https://t.co/TCQKwpCYKO by @NIAIDNews @cellhostmicrobe H/T @mtosterholm https://t.co/0iY0ec2HJA
2023-01-14 17:34:18 The ~80% bivalent booster vaccine effectiveness (US and Israel studies) summarized is compared to controls with prior infections, vaccinations and boosters, making that high level of protection for people age 65+ noteworthy
2023-01-14 17:30:39 The US did a great job getting its seniors vaccinated, with 94% having the primary series of 2 shots. But in the last 6 months, less than 40% have gotten a booster, and they account for most of the hospitalizations and deaths https://t.co/tR5S4BBaYb
2023-01-14 17:03:24 New insights on the gut microbiome-brain axis, based on https://t.co/kU2nnGA0uB @dongohseo1 and colleagues with @ScienceVisuals https://t.co/ndd8MfLa8P
2023-01-14 17:03:23 "These exciting results highlight the potential to harness the gut microbiota to prevent or slow the progression of AD and other tauopathies and raise awareness about the potential long-term effects of early-life diet" https://t.co/c4Xh83gekQ @Tan_ee_Ya @YuemingLiLab https://t.co/lLz2meYgR0
2023-01-14 15:00:15 RT @ahandvanish: Our review of #LongCovid research is out! This was a HUGE labor of love over 10 months from @julialmv @LisaAMcCorkell @Er…
2023-01-14 14:17:13 @zalaly @ahandvanish @LisaAMcCorkell @julialmv @NatureRevMicro Thanks Ziyad! Much of what we know about #LongCovid comes from your outstanding research contributions
2023-01-13 23:39:12 RT @loscharlos: Absolutely incredible work — a comprehensive overview on the explicit biological abnormalities of #LongCovid — thank you @E…
2023-01-13 23:39:06 RT @DrCaliff_FDA: The bivalent COVID-19 vaccines have been associated with a significant reduction in hospitalization and death in all popu…
2023-01-13 22:30:25 @CrabbBrendan @ahandvanish @LisaAMcCorkell @juliamv @NatureRevMicro Thanks Brendan!
2023-01-13 22:06:22 @nickiykwim @ahandvanish @LisaAMcCorkell @juliamv @NatureRevMicro Thanks for noting this Correct link @julialmv
2023-01-13 20:48:36 This was an outgrowth of a very long process, with multiple rounds of peer and editor reviews. In a field constantly updating. But it was all worth it to have the privilege to work with 3 all-star co-authors, each of whom have had #LongCovid. We hope you'll find it useful
2023-01-13 20:29:26 I amended my extensive review of the bivalent booster this week, which works better than expected, to comment on this issue https://t.co/tR5S4BBaYb
2023-01-13 20:29:25 Today the CDC reported a possible safety concern about the Pfizer bivalent vaccine, unconfirmed by any other dataset https://t.co/on5LcVmNwz @lauriemcginley2 @bylenasun https://t.co/Fwqg7YLpFn
2023-01-12 23:35:12 A couple of corrections to the Table, thanks to @BarouchLab —Moderna used a pseudovirus assay —The Suthar (Emory) study changed from 4-fold (bivalent vs original) to 2.3-fold vs BA.5 from their preprint to the @NEJM report https://t.co/cHyo16WjSE
2023-01-12 21:15:36 "These findings highlight the key role of antigen presentation at the mucosa and support a protective effect of mucosal immunity for up to 8 months" https://t.co/zUuVnRamin What nasal vaccines could simulate to achieve durable mucosal immunity https://t.co/lZv2BqyXh4
2023-01-12 19:29:28 RT @GeoffreySupran: NEW: In @ScienceMagazine today, our latest peer-reviewed research shows Exxon scientists predicted global warming with…
2023-01-12 17:27:15 For decades the #AI field has loosely used the term artificial neurons. Now they've really been made https://t.co/qpinCVNyEk artificial neurons that closely mimic the characteristics of biological nerve cells @NatureMaterials
2023-01-12 17:10:04 The problem of reduced T-cell immune response (CD4+) for people age 65+ to Covid vaccination https://t.co/kn5DAx8G2Z @NatureAging https://t.co/2djizJJc8P
2023-01-12 17:02:14 Beyond grim. A humanitarian crisis https://t.co/I7LJsdbbcm by @lilkuo https://t.co/EiyDxT9RRO
2023-01-12 16:56:27 Good news: In the Northeast where the XBB.1.5 variant now accounts for >
2023-01-12 15:51:27 RT @NightShiftMD: Read the fantastic review by @EricTopol. The bivalent booster dramatically prevents hosp and death esp in older patients…
2023-01-12 13:58:36 RT @Bob_Wachter: Important thread: @EricTopol was a bit skeptical about the bivalent when it rolled out. His detailed review of emerging la…
2023-01-12 02:13:26 I was quite skeptical in September when the bivalent was rolled out without human data. Now there’s compelling evidence to support its benefit.
2023-01-12 00:10:28 Fixed link @bmj_latest https://t.co/grs74wi8f4
2023-01-11 23:40:11 3. The vaccinated individuals did better: less dyspnea and more likeness to controls. 4. Children had more Strep throat &
2023-01-11 23:40:10 2. Major symptoms of difficulty breathing, cognitive impairment and weakness were present at 1 year. Also loss of smell, taste, dizziness and cough https://t.co/bF6hIauesm
2023-01-11 23:40:09 A new retrospective nationwide EHR assessment of #LongCovid in ~230,000 people w/ mild Covid and matched controls for age, sex, vaccination status, variant Some downplaying of persistent symptoms at 1 year: 1. Median age of cohort = 25 years. People age 41-60 had worse outcomes https://t.co/BV5qyoxQHU
2023-01-11 22:00:50 The Covid bivalent vaccine booster works better than expected. I've reviewed the cumulative data https://t.co/tR5S4BBaYb That's in contrast to a @NEJM essay today and 2 lab studies that used a pseudovirus assay without assessing the XBB variants
2023-01-11 19:58:14 Cell-free DNA fragmentation patterns and sequencing from small amounts of plasma hold considerable promise for screening and early detection of cancer https://t.co/9FRzcWj9Pj @ScienceTM https://t.co/ui6GlTSzyg
2023-01-11 19:05:38 Some #SARSCoV2 mutations that confer resistance to Paxlovid have been deposited @NCBI &
2023-01-11 18:28:23 Immune evasion of #SARSCoV2 typically refers to our antibodies having less neutralization capacity vs new variants. But our 1st line of defense, the innate immune system—interferons—also play a critical role as elegantly reviewed https://t.co/eCw4D5BslI @JudyMinkoff @virusninja https://t.co/jC64iN7Hx5
2023-01-11 18:01:02 @AshishKJha46 Referring to this brief thread post https://t.co/3LZnn5o3SU
2023-01-11 18:00:06 The Table accompanying this post was inadvertently deleted https://t.co/DMZlKiW4PZ
2023-01-11 17:54:53 RT @AshishKJha46: Dr. Topol is right. The evidence from high quality studies is clear: The bivalent vaccine is far superior to the origi…
2023-01-11 16:58:02 RT @WesElyMD: “China’s in the midst of a #Covid crisis w unmitigated spread &
2023-01-11 16:33:29 Health advice :-) by @stephanpastis https://t.co/PIB2TzkQup
2023-01-11 16:19:40 The lack of reproducibility issues that haunt medical #AI https://t.co/bG5ANEx2u4 @Nature https://t.co/jz5TJ8cyse
2023-01-11 04:03:40 An outstanding appraisal of #SARSCoV2 evolution as an antigen, the potential role of immune imprinting (original antigenic sin), and strategies to prevail https://t.co/OJGA1RA4kn @jclinicalinvest @MarionKoopmans @GijsbertNierop https://t.co/LaZvpQqXNZ
2023-01-10 20:54:27 While the bivalent booster was directed against BA.5, fortunately it broadens immunity and works better than the original booster for inducing antibodies vs BQ.1.1 and the XBB variants. Live virus assays are more reliable than pseudovirus
2023-01-10 20:44:17 Summary of the 8 lab studies for the bivalent BA.5 vaccine booster vs original. Neutralizing antibody (nAb) levels vs BA.5 and XBB variants All 5 live virus studies showed significant increase (3-8 fold) nAb increase for bivalent vs BA.5 and some cross-immunity vs XBB https://t.co/r4UuBdobhE
2023-01-10 17:57:36 "These data demonstrate that MVA-S vaccination confers a complete protection against #SARSCoV2 brain infection and the associated neuropathological damage (neuronal loss and vascular damage), even after a second viral infection." https://t.co/rHzB2Yu4hD @NatureNeuro @ibis_sevilla https://t.co/rzGOTPkeAe
2023-01-10 16:59:16 Bacteria play a more significant role in cancer than we previously envisioned, as we've recently been learning via spatial genomics https://t.co/E0tvczq68A @ImmunityCP @natedandy_PhD @sangerinstitute https://t.co/mi9MqNbxc3
2023-01-10 14:32:06 "The bivalent booster vaccination enhanced neutralizing antibody titers against all Omicron lineage viruses tested, including a 10-fold increase in neutralization of BQ.1 and BQ.1.1 viruses that predominated in the US." https://t.co/MbyhV05r9j
2023-01-10 14:15:03 “It’s almost certainly going to dominate in the world. I cannot find a single competitor now. Everything else is incomparable.”—@yunlong_cao https://t.co/bo13QV7xVo
2023-01-09 22:16:05 Let's create some proteins [Stop dilly-DALL-E-ing with silly images] Potential for foundation #AI models to impact life science https://t.co/kbqTbzDWzn @CadeMetz https://t.co/4C7Pa6kF9n
2023-01-09 21:55:02 These data align with the recent CDC analysis https://t.co/rqkjmug1ki
2023-01-09 20:47:44 The bivalent booster in people age 65+ compared with those who did not receive it, among >
2023-01-09 19:35:47 Cancer cells can change the shape of their nucleus to facilitate their spread throughout the body
2023-01-09 16:36:49 So powerful. Unforgettable. Thank you @celinegounder https://t.co/I9DoGvlJpW https://t.co/8BCe7j3bzV
2023-01-09 16:25:18 The association of healthy heating habits and reduced mortality in 2 large cohorts, ~120,0000 people, with up to 36 years follow up. across all racial and ethnic groups https://t.co/qcpcuCdxzX @JAMAInternalMed with the usual diet study caveats @HarvardChanSPH https://t.co/MZ8nCJfyBX
2023-01-09 15:45:26 Our digital times :-) https://t.co/5wC9nvEZ0T
2023-01-09 15:20:36 The virus is talking. We're not listening https://t.co/k6ymRyUE6f https://t.co/7JOxoWbu3R
2023-01-09 00:49:15 “The implications of XBB.1.5 are also much bigger than just this formidable variant. The virus is talking to us, and it is telling us it has many more ways to evolve.”
2023-01-09 00:25:52 “That [XBB.1.5] should serve as a wake-up call for the country to re-invest in new vaccines, treatments and pandemic monitoring”
2023-01-08 16:30:40 What the XBB.1.5 variant is telling us. And what we can do about it. My oped @washingtonpost https://t.co/k6ymRyUE6f @PostOpinions https://t.co/PQnsAl0YzZ
2023-01-08 03:31:52 RT @HamlinIsland: Putting love into the world comes back 3xs as much… thankful for everyone who has reached out and prayed. This will make…
2023-01-07 22:37:46 The poor pharma industry https://t.co/oZ7fhX3D9i by @david_wainer "It’s in the industry’s best interest to say the sky is falling”—@DusetzinaS https://t.co/3g0cdrdiXo
2023-01-07 19:30:37 There are important differences between multisystem inflammatory syndrome in children (MIS-C) vs Kawasaki's disease, but still much to learn about its pathophysiology https://t.co/TIg9U0knK0 https://t.co/j3YU5eq78f
2023-01-07 19:22:08 Good graphic to convey an important negative trend https://t.co/2f2TaSsogQ @maxdkozlov https://t.co/i3WYhUI3f7
2023-01-07 19:02:39 @RickABright @GISAID Community extrapolation only, unfortunately
2023-01-07 18:50:36 But in North Carolina, with much lower % XBB.1.5, a similar spike in hospital admissions among seniors, which supports other factors besides this variant as a principal driver https://t.co/1nk28wAwHT
2023-01-07 18:50:35 The notable rise of Covid hospitalizations in the Northeast, where XBB.1.5 variant accounts for ~75% cases, among people age 70+, especially in Massachusetts (approaching ~80% of its BA.1 wave) https://t.co/OYKQV32gvz https://t.co/aVyTHlHXiQ
2023-01-06 22:06:50 RT @aetarke: Can CD4+ T cells cross-recognize different coronaviruses (CoV), offering immune protection from potential future CoV pandemics…
2023-01-06 19:24:21 You would think the @US_FDA would have learned from Aduhelm. This drug is not deserving of any accelerated approval https://t.co/AsbZSO0RhF
2023-01-06 17:23:27 New York, where the XBB.1.5 variant was first detected, and the US bellwether for its growth, still shows signs of increasing hospitalizations, particularly for those age 70+ https://t.co/3YFO480SJ6
2023-01-06 17:16:37 Northeast region dominance of XBB.1.5 unchanged, 5 of the 8 regions still in single digits https://t.co/013DOVZXwF
2023-01-06 17:16:36 New @CDCgov #SARSCoV2 variant report Corrects/ lowers XBB.1.5 proportion of new cases from ~40% (last week) to 28% nationally now, leaving more runway before this variant achieves dominance cross country. No other variant showing growth https://t.co/jjl2AnOYb5 https://t.co/SGHJmQ12NH
2023-01-06 06:06:36 I’d reject their proposal for various reasons, but will let you and respondents air it out
2023-01-06 05:43:03 A new explanatory model proposed for #LongCovid https://t.co/62ztuTDsPH @LancetRespirMed "an embodied condition with heterogeneous biological, psychological (experiential), and social (or environmental) factors integrated in complex relationships" https://t.co/8ygX8cYeqc
2023-01-06 00:59:42 A new study finds no indication of autoantibodies, an intact immune response vs controls (antibody and T cell) but evidence of persistent, elevated circulating full-length spike protein unbound by antibodies https://t.co/mdYuj6x2Ww https://t.co/0OSC1NNg0g
2023-01-05 20:08:04 The essentiality of wastewater surveillance "Core component of infectious disease monitoring, providing a variant-specific, community-representative picture of public health trends that captures previously undetected spread and pathogen transmission links" https://t.co/D0D8WcP2bM
2023-01-05 19:57:47 How obesity can induce neuroinflammation: Reprogramming innate immunity, particularly macrophages (via epigenetics), can facilitate age-related macular degeneration in an experimental model https://t.co/Q1seFXIxwk https://t.co/JPEsOfWlSg @ScienceMagazine https://t.co/5jQMrO4hZ7
2023-01-05 19:44:40 The hidden humanitarian Covid crisis in China https://t.co/3ejhlzkLvv @ScienceMagazine https://t.co/vUaOtrxJAm @joyuwang @kaltoons https://t.co/dNAfxw21Iq @hj257 https://t.co/ymFhguPllj
2023-01-05 17:39:35 "All around the world, Covid surveillance is faltering. That, rather than the surge of cases in China, is the main reason for worry" The number of sequences submitted @GISAID has dropped 90% https://t.co/noDmDB4bDZ
2023-01-05 00:58:42 RT @TWenseleers: @BrunnCarrigg @Tuliodna @EricTopol Also see graph below. There is some registration delays apparently... https://t.co/ECnM…
2023-01-05 00:58:33 RT @TWenseleers: @BrunnCarrigg @Tuliodna @EricTopol The effect, like for BQ.1, will be felt mainly by seniors (which is perhaps why Tulio t…
2023-01-04 23:08:43 https://t.co/rHe6SJNWsg
2023-01-04 23:07:45 From studying transmission of the Delta and Omicron variants in nearly 2000schools and 300 preschools in Australia: “community restrictions, rather than school closures, best mitigated COVID-19 impacts.” https://t.co/wOruadiPk8…
2023-01-04 19:17:36 @Tuliodna Dear Tulio, I don’t think it’s being overplayed due to its remarkable growth advantage and very rapid rise to dominance here and likely much of the world But I agree that our immunity wall will undoubtedly blunt its impact
2023-01-04 19:12:51 “Our results highlight the importance and feasibility of a universal vaccine to fight against SARS-CoV-2 antigenic drift.” @ScienceTM https://t.co/yrNkWjQwb2
2023-01-04 18:21:31 No, vaccines DO NOT induce variants. That's what infections do. Blatant misinformation: "Growing evidence also suggests that repeated vaccinations may make people more susceptible to XBB" https://t.co/JroxuQpxe8
2023-01-04 17:55:53 The #SARSCoV2has been relentlessly evolving over the past 3 years to find new hosts. Its latest iteration, XBB.1.5, acquired a critical double mutation that maintains high level of immune escape while increasing infectivity by @yunlong_cao and colleagues https://t.co/32QqpChRVR https://t.co/M2GxCbmcgs
2023-01-04 17:27:58 Science and technology are getting less disruptive on the basis of 45 million papers and 3.9 million patents published in the past 6 decades https://t.co/7RxiutNR9z @Nature @russellfunk @michae1park https://t.co/RHLYmJYQz6
2023-01-04 16:35:32 The breakthrough obesity drugs, a new feature @Nature https://t.co/wXRkQe0Tyw by @meprillaman aligns with my recent review https://t.co/SMZO20WGRs https://t.co/VxLQzCwHzN
2023-01-04 16:28:20 The @UF faculty report on Florida surgeon general Ladapo's "seriously flawed," "careless, irregular, or contentious [vaccine] research practices" https://t.co/W7JQsRUWlT https://t.co/r2HxNltPve
2023-01-03 23:05:34 Why hasn't Paxlovid implementation lived up to its expectations? Prescribed for only 13% in the US &
2023-01-03 21:36:50 A hopeful turning point for Japan after having gone through its worst wave for fatalities https://t.co/ifrPlXXEdc
2023-01-03 21:19:07 @JohnKasich @vkhosla Meanwhile, for comic relief you can't beat @themattfriend https://t.co/RtXHTP5kYw
2023-01-03 21:11:36 Exceptional new reviews of the 12 interconnected biologic hallmarks of aging @CellCellPress and cancer @Cell_Metabolism https://t.co/WViWtj4NK6 https://t.co/WRDQokSbiZ https://t.co/NIWny2torf
2023-01-03 16:53:30 @TWenseleers Much appreciated, Tom
2023-01-03 01:01:35 ~63% of Americans age 65+ have not had a recent/bivalent booster, leaving them vulnerable —Lab data supports some bivalent booster cross-immunity protection vs XBB.1.5, even though it was BA.5 directed —Before XBB.1.5 becomes dominant across the US, that's a way to help defend
2023-01-03 00:45:47 That's >
2023-01-03 00:43:38 I reviewed all we know about the XBB.1.5 variant 10 days ago, w/its high transmissibility https://t.co/mnaA3kemLp The ? now is whether it will have a material impact on adverse outcomes, for which there is some evidence among seniors in states with >
2023-01-02 19:55:06 Annual sales of tirzepatide (Mounjaro) may reach $48 billion, far surpassing prior records. I reviewed why these new obesity drugs are a breakthrough, but also a liability https://t.co/FUYOzzzm73 https://t.co/SMZO20WGRs
2023-01-02 19:49:58 Unraveling #Alzheimer's disease by single-cell genomics, a new tour de force review https://t.co/Wihfht4gbe @NatureNeuro @mhmurdock1 @DrLiHueiTsai @MIT https://t.co/R0B7Jwa6WW
2023-01-02 17:31:06 Comparative effectiveness of Pfizer vs Moderna booster shot in US Delta and Omicron waves via large @DeptVetAffairs experience https://t.co/ecVit591vO Significant less symptomatic infections and hospitalizations among those treated with Moderna @NatureMicrobiol https://t.co/8lV7RpmRni
2023-01-02 17:19:32 abstract and key figure https://t.co/jSVOfYQJna
2023-01-02 17:11:42 New @NatureMedicine Proof that Covid vaccines do reduce Omicron transmission from prison data, but the impact is ~20-40% https://t.co/du9ABpahEq
2022-12-31 22:31:29 RT @BNOFeed: BREAKING: Number of Americans hospitalized with COVID-19 rises to 45,279, the highest since February
2022-12-31 22:29:13 RT @JPWeiland: I can confidently say XBB.1.5 will NOT approach the levels of hospitalizations and deaths seen in the initial Omicron wave i…
2022-12-31 18:33:05 Where were the major #SARSCoV2 variants that led to continental or global dominance first detected? Alpha—United Kingdom Beta—South Africa Gamma—South America Delta—India Omicron—Southern Africa XBB.1.5—United States
2022-12-31 18:19:50 “If you make a big bet, and you’re successful with a program [Operation Warp Speed], you should keep making big bets" https://t.co/zHVRYmP4vW @SmithsonianMag by @SimarSBajaj
2022-12-31 18:05:04 @bwizel @TRyanGregory Thank you!
2022-12-31 16:24:03 RT @Ideas_Sleep: 'The UK is incontrovertibly the world leader in genomics' – @EricTopol In 5-10 years, the UK looks set to lead the way i…
2022-12-30 21:13:00 RT @BNOFeed: Number of Americans hospitalized with COVID-19 rises to 44,138, the highest in more than 5 months
2022-12-30 20:06:17 Here for all ages 18+ Similar relative reduction, less absolute, for bivalent vs non-bivalent or without vaccination https://t.co/M2Bu9r1YTe https://t.co/CMKyrM4pl6
2022-12-30 20:00:31 New data for bivalent protection vs Covid hospitalization For age 65+, >
2022-12-30 17:34:58 Current US regional variant map. XBB.1.5 just getting started in multiple regions https://t.co/XM3fjdtoYB
2022-12-30 17:18:57 @JuliaRaifman Right, Julia. Unfortunately, That’s the XBB.1.5 signature seen in many Northeast WW in recent days
2022-12-30 17:16:26 All we know about the XBB.1.5 variant summarized here a week ago https://t.co/mnaA3kemLp We’ve not seen such rapid growth of a variant since Omicron BA.1 a year ago. Total US XBB last week = 18% of cases. Northeast now ~75% XBB.1.5. Perhaps CDC and media will finally take note
2022-12-30 17:05:15 Wow. XBB.1.5 more than doubled across the United States in 1 week, now ~40%, out-competing all variants https://t.co/PeE8P7eAeH
2022-12-30 16:14:48 @chrischirp Heading towards multi-continental dominance, first one USA evolved (first detected in New York)
2022-12-30 01:39:00 @ansonjtong You'll be hearing a lot more about it tomorrow (finally)
2022-12-30 01:38:24 Among the best @nytgraphics for 2022, this one for #LongCovid really stands out https://t.co/pYPLoTTQUj @joshkellerjosh
2022-12-29 19:50:11 "This is not how epidemiology works. One cannot extrapolate a death rate across a nation from a single death." —@kmpanthagani https://t.co/Le7cUb4nlI https://t.co/KQWzZkN4hY
2022-12-29 18:20:37 For people age 65+, the bivalent booster linked to >
2022-12-29 17:42:09 @jordan_peccia @kmpanthagani This is what XBB.1.5 looks like
2022-12-29 17:16:23 The predictive utility of a heart disease polygenic risk score for primary prevention, use of statins, especially in people less than age 50 https://t.co/hCMjfzTxgX @JAMACardio by @marstonMD and colleagues https://t.co/JmwBIKB4pu
2022-12-29 15:56:40 With focused on China, Japan, a country w/ one of the best pandemic outcomes, as previously reviewed: https://t.co/z68bDAQuhi is experiencing its worst death toll, during a 2nd BA.5 wave, with waning immunity, under-boosted, and 25% population age 65+ https://t.co/o7TgtHAgWn
2022-12-28 23:50:14 I asked why, with all the evidence, there is such resistance to accepting that masks help (for all respiratory viruses) https://t.co/rPJBJ0VjOh
2022-12-28 23:50:12 Transcript is now posted. Here is Prof @linseymarr explaining 1- and 2-way masking impact https://t.co/tkIvdxRmgd https://t.co/cbhQPkm4oT
2022-12-28 22:42:41 New @NEJM A randomized trial of an oral remdesivir analog drug (VV116) vs Paxlovid suggests it may provide an alternative (fulfilling the pre-specified non-inferiority criteria, but 1.17 hazard ratio) https://t.co/ytECEc0Fvb https://t.co/TmvZTCWDMe
2022-12-28 15:57:51 This is the summary of all @CDCgov and media coverage of the XBB.1.5 variant to date https://t.co/R5jKtidChB
2022-12-28 15:53:30 There are ~7 million Americans who are immunocompromised, more vulnerable to severe Covid, and now Evusheld rendered ineffective. We've just launched a new direct-to-participant-research program with free molecular tests &
2022-12-28 05:24:39 We’ve just launched a new research program for immuncompromised individuals in the US with free home molecular testing and rapid access to medications when needed. Please help spread the word https://t.co/PfZGBYjcQi
2022-12-28 02:22:28 I've updated this post on the XBB.1.5 variant with new data provided by @yunlong_cao, @JPWeiland and @rquiroga777. For those questioning what could be done if CDC/media raised awareness (for which there has been none), that is addressed, too. https://t.co/mnaA3kemLp
2022-12-28 01:53:57 @yunlong_cao @JPWeiland @LongDesertTrain Thanks Yunlong. That’s precisely the piece that was missing….that you’ve filled in once again
2022-12-28 01:13:39 @SystemsVirology @yunlong_cao @biorxivpreprint Thanks @SystemsVirology! Have you done any assays for XBB.1.5?
2022-12-27 23:19:45 RT @JPWeiland: I overlaid some of @trvrb group's analysis of effective Reproductive Number over time since a variant first starts spreading…
2022-12-27 20:18:17 It started in New York, now contributing in contiguous states, like Connecticut https://t.co/MOQpgmNWGl https://t.co/H6fLKYP2LU
2022-12-27 19:43:01 A functional @CDCgov would alert the public about the XBB.1.5 variant—which has already established dominance throughout the Northeast—and, with its big growth advantage over BQ.1.1, soon country-wide. https://t.co/tL2Y2HF2ew
2022-12-27 00:38:23 The Outlier 2021 US health care expenditures: $4.3 trillion
2022-12-26 23:38:46 @rquiroga777 Thanks so much, Rodrigo. I think your graphic is the best way to simply and accurately represent the progression of mutations that led to XBB.1.5. I revised the Substack post to include it https://t.co/mnaA3kemLp
2022-12-24 21:48:54 RT @LongDesertTrain: Excellent piece by @EricTopol on XBB.1.5, which @JPWeiland first called attention to a couple weeks ago. Nothing is ce…
2022-12-24 19:56:55 @macroliter Agree. To be announced soon
2022-12-24 19:15:21 @Globalbiosec Thanks so much, Raina. Very kind of you! All the best for the holidays
2022-12-24 18:38:54 Highly recommended for straight talk about airborne transmission of respiratory viruses (including #SARSCoV2) and how we can defend against it
2022-12-24 18:11:23 I've added citations to @jbloom_lab @LongDesertTrain @RajlabN. All indications are that XBB.1.5 will become dominant throughout the US in the weeks ahead, the 1st variant evolved here to have such marked growth advantage.
2022-12-23 22:48:03 Special thanks to the people who have been carefully tracking the variants, whose work is referenced in this post @yunlong_cao @JPWeiland @dfocosi @rquiroga777 @PeacockFlu @CorneliusRoemer @richardneher @siamosolocani @firefoxx66 https://t.co/pHj2uAkZiI @nextstrain
2022-12-23 20:31:57 @NoAutocracy Appreciate your feedback
2022-12-23 19:50:30 I wrote about the XBB.1.5 variant in the United States https://t.co/mnaA3kvpNp
2022-12-23 18:34:35 During surgery, frozen sections of tissue are obtained for key decision making (e.g. resecting a tumor) but there are problems w/ speed &
2022-12-23 18:23:31 "Our study demonstrates that [Molnupiravir] this commonly used antiviral can supercharge viral evolution in immunocompromised patients, potentially generating new variants and prolonging the pandemic." https://t.co/dRr0ifMF6t
2022-12-23 17:29:40 The good news is that the US flu season has peaked, started descent https://t.co/GoRVfCcLvn
2022-12-23 15:52:40 More here https://t.co/spPWEERiJf
2022-12-23 15:32:39 New York is the XBB.1.5 bellwether A brief thread on what's going on there and this variant https://t.co/B9hkn2MeeB
2022-12-23 15:30:20 New US #SARSCoV2 genomics indicates an important shift to XBB gaining on BQ.1.1. While the BQ.1s are dominant overall, the Northeast is now XBB dominant (particularly rapidly growing XBB.1.5) https://t.co/jjl2AnwOWX https://t.co/0wSbgRjtTK
2022-12-23 04:13:13 The 2 key mutations beyond XBB that appear to be linked to XBB.1.5's big growth advantage https://t.co/a1SGsKkRqr
2022-12-23 03:30:19 Look what's happening in New York State XBB (likely XBB.1.5) is quickly outcompeting BQ.1.1 https://t.co/uY35MktbbN https://t.co/XaOJRvMEnx
2022-12-23 03:20:29 What variant has the highest growth advantage of all in the mix right now https://t.co/PInFKwKIlz XBB.1.5 (based on a large number of sequences) https://t.co/ELJyQTlMlR
2022-12-23 02:07:28 If you like impersonators, Matt Friend is amazing His range seems limitless and he moves from one character to another like I've not seen before (maybe Robin Williams). https://t.co/nB91MxXL4t
2022-12-23 00:38:00 RT @linseymarr: What a delight to chat with @EricTopol for a @Medscape podcast about virus transmission and interventions!
2022-12-23 00:21:55 While the time to recovery was shortened, the price to pay is a very high rate of #SARSCoV2 mutations induced (its obligatory mechanism). That alarming rate has been amply documented by @LongDesertTrain https://t.co/RIPTr3useX https://t.co/ignWWSTU9B
2022-12-22 23:30:00 Just out @TheLancet Failure of Molnupiravir to reduce Covid hospitalizations or deaths in a very large randomized trial (N>
2022-12-22 21:42:17 Highest Covid hospitalizations in New York since January and soaring in seniors, as the XBB variant with added mutations gains growth advantage https://t.co/cz0BwwaIM3 https://t.co/AE7Gh7fQ1P
2022-12-22 20:04:00 My conversation this week with Prof @linseymarr, a civil engineer and leading authority on air quality, viruses, and the impact of masks. She's a remarkable explainer and my go-to expert on this topic https://t.co/cX7MPqhVjE #COVIDIsAirborne @Medscape
2022-12-22 19:16:03 Late after mRNA Covid vaccines, or with booster or breakthrough infections, there is a shift to IgG4 antibodies, not seen with adenovirus vector vaccines. The clinical significance is not known https://t.co/5thLxRwemm @SciImmunology @UniFAU https://t.co/YozSLVjVLd
2022-12-22 18:38:38 Another death in the lecanemab trial https://t.co/yX1xWdZ1TM @ScienceMagazine @cpiller
2022-12-22 17:58:15 RT @erikbryn: The news about life expectancy in America is devastating. Covid is taking a huge toll, but so are other causes like drug over…
2022-12-22 17:42:16 "We discovered large-scale mother-to-infant interspecies transfer of mobile genetic elements, frequently involving genes associated with diet-related adaptations." https://t.co/36B9VDy6QN by @tvatanen and colleagues @broadinstitute https://t.co/3aoXtFImGX
2022-12-22 16:57:02 BTW the cover of @CellCellPress this week shows #3D the aortic regions of a human heart whose vascular plaques are analyzed by DISCO-MS (#AI) technology (1st post in this thread) https://t.co/9n0KNUtS1T
2022-12-22 16:51:01 More jumps in the era of spatial omics 3D proteomics of intact tissue with #AI https://t.co/R7rhPr8jAj @CellCellPress @erturklab @labs_mann
2022-12-22 16:21:55 Great to see that we're making headway against KRAS, a driver of so many cancers that were previously untreatable by target. Two @NEJM reports vs the KRAS G12C mutation https://t.co/4ghBGdroZw https://t.co/1Y5nRDaBkF https://t.co/WSRRqMHoWp
2022-12-22 15:17:24 Now at a 25 year low, life expectancy in the US continues to fall. Covid persists as the 3rd leading cause of death and increasing ~20% over 2020 https://t.co/KldEystLDM @littlewern @jon_kamp https://t.co/hWpAGoQ49g
2022-12-22 01:21:01 @emollick Agree!
2022-12-21 23:53:08 When the #AI couldn't pass the radiologist qualifying examination @BMJ_latest (with special dispensation) @SusieShels @JWeirMcCall and colleagues https://t.co/CRGgMzdCTM https://t.co/m3aoYeAGZi
2022-12-21 22:59:26 Full text. One of multiple lab studies now to show the bivalent booster helps increase the immune (neutralizing antibody) response vs BQ.1.1 and XBB https://t.co/dejyM7rNrb
2022-12-21 22:01:00 New @NEJM "Persons who received the BA.5-containing bivalent booster had better neutralizing activity against all Omicron subvariants (especially against BA.2.75.2, BQ.1.1 and XBB) than those who received 1 or 2 monovalent [original] boosters" https://t.co/5m6Pmahli3 https://t.co/zuiyGWmAfC
2022-12-21 20:29:50 Coverage of this report https://t.co/GqUy6rIxLR by @dmosbergen https://t.co/XWUK5aLNWn
2022-12-21 19:18:05 A step towards improving potency of immune response for RSV vaccines. Stabilizing the pre-fusion conformation, as used in many Covid vaccines @ScienceTM https://t.co/CxDiDh0j24 @RuckwardtTracy @lauren_a_chang @NIAIDNews https://t.co/eWzSsA9DTo https://t.co/ayEPSvIUqh
2022-12-21 19:00:03 Why do some people have persistent loss of smell post-Covid? A biopsy-based study shows durable T-cell mediated inflammation long after the virus is cleared from tissue @ScienceTM by @goldstein_brad and colleagues https://t.co/5iG5ZaCtTX https://t.co/u56zCWlIGF
2022-12-21 16:13:28 New @Nature A significant discovery underpinning glioblastoma, a deadly brain cancer, involving an epigenetic target (BRD8) that blocks P53's guardian function https://t.co/N9rVOz9WkR by @CSHL @SunSherine @olaf_klingbeil and colleagues https://t.co/sEeQJZNOF3
2022-12-21 15:17:46 in today's NYT https://t.co/WP0LxOVR0X @Emily_Baum https://t.co/b39VTSo60o
2022-12-21 01:51:34 RT @elonmusk: I will resign as CEO as soon as I find someone foolish enough to take the job! After that, I will just run the software &
2022-12-20 23:47:39 The Framingham Risk Score for heart disease originated 25 years ago. Today @TheLancet a new holistic score/model was tested and validated in 2 large biobanks https://t.co/Bs1lnkrnTE @DoGenetics @IainSForrest @IcahnMountSinai @OmegaPetrazzini #AI https://t.co/ya5HqCP2Bg
2022-12-20 23:23:09 Repeated exposures to Covid or vaccines have little impact on spike-specific T cells in the circulation, in contrast to antibodies https://t.co/VYo9oo5m5h (does not address T cell breadth, homing, or durability) by @virusmonologues and colleagues @UCT_news https://t.co/W30IcpHUZF
2022-12-20 22:30:05 @drjorgemd No
2022-12-20 22:02:17 @SworldWilly @OurWorldInData Tell me about it https://t.co/sVhhbOMWfh
2022-12-20 21:40:15 For the "it's a cold" and "the pandemic is over" folks https://t.co/mzIAinl8LS
2022-12-20 21:24:19 Twitter turmoil and its influence on science https://t.co/qMgq0m0SOx w/ @CT_Bergstrom @trishgreenhalgh @OdedRechavi @RodrigoCostas1 @dsquintana @siggs28 @BristOliver
2022-12-20 19:43:42 @T_Brautigan @eBioMedicine @FelicityLiew @ShubhaTalwar @VirusesImmunity @SciImmunology No science? Goodbye.
2022-12-20 19:35:21 RT @p_openshaw: Thanks @EricTopol for flagging our study- big collaborative effort by @CCPUKstudy and especially @FelicityLiew ,@InThwaiteI…
2022-12-20 18:51:17 A stroke that emanates from the left atrium doesn't require atrial fibrillation. A prospective study of atrial cardiopathy https://t.co/uAHcz5NiIP https://t.co/HcU3TIF5IP @AnnalsofIM @faye_epi @EmeliaBenjamin @darae_ko https://t.co/gyIQZobreX
2022-12-20 17:56:29 I recently reviewed the new breakthrough obesity drugs https://t.co/SMZO20ExDk A new @PostHealthSci piece by @lauriemcginley2 and @LennyMBernstein hits on many useful, practical points https://t.co/eZDN44geuu https://t.co/UgA2gG4ZLe
2022-12-20 17:11:25 A good sign. France, the 1st country to face the BQ.1.1 variant dominance, and the US, were running neck and neck for Covid hospital admissions. Now they're diverging and France is in descent for cases. @OurWorldInData https://t.co/Gl7UoLZ6AX
2022-12-20 16:53:34 We keep evolving.... "A more expansive view of the functional potential of the human genome... embraces these hard-to-detect, small, but significant proteins that show no traces of conservation." https://t.co/SBgKjQZlsQ @CellReports https://t.co/79md3Qm4bo
2022-12-20 16:47:58 @T_Brautigan @eBioMedicine @FelicityLiew @ShubhaTalwar Maybe you should read about it, like the piece I wrote with @VirusesImmunity @SciImmunology, before sending DON'T replies. #SARSCoV2 ≠ flu. https://t.co/OujfFxMgU6 https://t.co/KdVRVVp5fM
2022-12-20 16:25:13 We just learned a lot more on the genomics of colon cancer. A multi-omics approach in over 100,000 cases shows association cumulatively up to 73% of familial risk @NatureGenet @fredhutch and global collaborators https://t.co/mguJS3KpAj https://t.co/KxwMkFL8nU
2022-12-20 15:29:01 New @ScienceMagazine Following Covid, MIS-C, the rare and potentially lethal multisystem inflammatory syndrome in children, has been elusive for its biologic basis. Today a report of 5 unrelated kids with genetic OAS-RNase L deficiencies https://t.co/LHgIlLeMIS Link needs fixing https://t.co/V1CguLr844
2022-12-20 15:07:06 RT @ScienceMagazine: The authors of “Gradual emergence followed by exponential spread of the SARS-CoV-2 Omicron variant in Africa” are retr…
2022-12-20 01:34:38 The Figure tells the story https://t.co/cqKaP7J4J3
2022-12-20 01:26:34 Why we desperately need nasal vaccines to block infections and reinfections https://t.co/hzYDvrq34M @eBioMedicine by @FelicityLiew @ShubhaTalwar and colleagues https://t.co/G3nJiGwiSz
2022-12-19 20:22:34 RT @kmpanthagani: You may have heard the shocking headline that 250,000 people die every year in the US due to misdiagnosis in the ER. You…
2022-12-19 20:15:30 The 1st drug to show efficacy vs NASH (nonalcoholic steatohepatitis) in a Phase 3 randomized trial after a long run of negative trials https://t.co/8tsaLo35r7 https://t.co/A4teHc8M84 https://t.co/Lr3iBlbPKK
2022-12-19 17:10:59 Rapid sequencing of blood or relevant body fluids can identify the root cause of serious infections and help guide therapy (in less than 8 hours), but, with rare exceptions, it isn't being done. Now ~9 years after proof of its lifesaving capacity https://t.co/Hr6AVrNBRB https://t.co/Sy8UUXWIQo
2022-12-19 16:51:05 The tonsils and adenoids of children who have had Covid have persistent tissue-specific immunity which includes antigen-specific memory B and T cells https://t.co/fxTpLKz1oU @NatImmunol by @ManthiramMD and colleagues @NIAIDNews https://t.co/dkxB458zgt
2022-12-19 16:31:50 The diverse prospects for nanomedicine to tackle Covid-induced clotting and related inflammation https://t.co/b6TNXIFHaZ @NatureNano @peijerussell @NicoVoelcker @MIPS_Australia https://t.co/25DyKFvYvG
2022-12-18 19:26:35 Good explainer for what I think was the most interesting paper last week @ScienceMagazine https://t.co/hIgBViXMaJ https://t.co/t4a8zLNt8P
2022-12-18 19:03:35 Link to graph https://t.co/Cze8bZxwXr Link to 94% of people age 65+ had 2 shots and only 36% have had a recent booster https://t.co/WWoVjw5Bll Link to the new data on booster impact reduction of hospitalization age 65+ https://t.co/sAxR8IxKgr
2022-12-18 19:00:07 The US "senior wave" of Covid hospitalizations has already exceeded the summer BA.5 wave and may soon surpass the Delta wave. Most of these admissions could have been prevented with a booster shot. https://t.co/plG8BngKxy
2022-12-18 18:49:44 @billbrown Historically yes. Both those challenges have now been squarely addressed in thousands of such diagnosed patients with costs of desktop sequencing and reagents not a barrier. Think about the cost of 1 day in the ICU
2022-12-18 18:41:18 @nanopore @GSTTnhs Thanks @nanopore. I forgot about that paper (even though I posted it at the time it was published last year). I've revised the substack to include it and appreciate all you're doing to make clinical metagenomics the standard of care
2022-12-18 16:28:20 Rapid sequencing of a person's blood or relevant body fluid can determine the root cause of a serious infection. Why isn't this standard medical practice?https://t.co/Y8eZSBaTZI https://t.co/dFklQ7Y4Yg
2022-12-18 01:43:22 @alexmeshkin @WHCOVIDResponse February 2023
2022-12-18 01:40:48 Impressed. Ordered 15 Dec
2022-12-17 22:32:50 @mdhhsu I did
2022-12-17 22:15:11 Why don't we use rapid sequencing (metagenomics) to identify the cause of sepsis? https://t.co/Y8eZSBaTZI
2022-12-17 16:08:09 When you consider that much of the new data on bivalent booster protection is based on comparison with people who have had multiple shots and boosters, and infections, it's particularly impressive https://t.co/sAxR8IxKgr
2022-12-17 16:03:32 Sorry, that's @fmanjoo
2022-12-17 15:57:56 @Veinless @kyle_minogue @CDCMMWR The BA.5 bivalent, the only bivalent in the US
2022-12-17 15:56:05 This is really well done, by both @manjoo and #ChatGPT https://t.co/2StExLekaE @nytopinion https://t.co/fM7K6sgMwM
2022-12-17 15:39:36 The tripledemic #dataviz https://t.co/aR5bQXSeFE by @amyswalk @nytgraphics https://t.co/eivKuuoyao
2022-12-16 22:02:25 @cwarden19 Thanks for your reply. I’ve put a clarification about the comparator group and context with prior reports
2022-12-16 21:59:25 Clarification: this study compares vaccine-induced myocarditis with viral myocarditis (not Covid). There are several other reports that I’ve previously posted w/ direct comparison with Covid myocarditis
2022-12-16 21:48:00 RT @thehowie: "If you want to give a great holiday gift to any and all seniors you know, that could be life-saving or prevent a hospitaliza…
2022-12-16 21:19:48 The natural history of vaccine-induced myocarditis for outcomes such as heart failure, dilated cardiomyopathy, or death is far different—more favorable—than from Covid myocarditis (besides the latter being considerably more common) https://t.co/2de1Eth12N https://t.co/UKOMRKYNt0
2022-12-16 20:27:19 Where is the new @NIH Director with Francis Collins having stepped down a year ago? @hholdenthorp is on it https://t.co/WtwrtcHIi7 @ScienceMagazine https://t.co/fLHV76Sufz
2022-12-16 20:15:30 Here's my quick update for what we now know about the bivalent booster impact on outcomes https://t.co/sAxR8IxKgr
2022-12-16 18:53:14 Until now the immune escape of BQ.1.1 and XBB has been largely (if not exclusively) assessed via neutralizing antibodies. Here are new (in silico data): the T cell responses (CD4+, CD8+) are likely intact vs these variants, which helps prevent severe Covid https://t.co/j2ycDYFtU1
2022-12-16 18:24:31 Here are the new data for the bivalent booster for all ages vs emergency room and urgent care visits https://t.co/tedNCNoYV2 https://t.co/Fpzo6UoiQi
2022-12-16 18:07:42 Yet 64% of seniors in the US have not had a recent booster https://t.co/WWoVjw5Bll And seniors account for nearly all of the rise of Covid hospitalizations https://t.co/Cze8bZxwXr https://t.co/OKJoCnapvr
2022-12-16 17:56:29 First look at bivalent booster vaccine effectiveness vs hospitalizations through November for age 65+ Strong protection >
2022-12-16 17:22:33 The new, potent anti-obesity drugs have impact beyond reducing obesity https://t.co/v0YRKWjZXa @NatureRevEndo I reviewed in some depth here https://t.co/SMZO20ExDk https://t.co/vbujFvTU1s
2022-12-16 16:53:20 A call to action for rebooting randomized clinical trials by leading cardiologists, published in @CircAHA @JACCJournals @ESC_Journals https://t.co/DB454UYfWY particularly to use digital technologies, reduce cost, improve efficiency and speed https://t.co/R8u58iSId9
2022-12-16 15:44:13 XBB's double-digit % presence in the Northeast. https://t.co/KXVXx8r0qs
2022-12-16 15:44:12 The BQ.1 variants rise in the US to ~70%, updated today. BQ.1.1 itself (38%) is still not dominant
2022-12-16 00:22:35 Reducing symptoms and increasing activity in a small cohort of people with #LongCovid using pacing https://t.co/1uKg2x046z https://t.co/QVEAOhQsFm
2022-12-16 00:10:32 200 years after the birth of Louis Pasteur, the most visible scientist of his century "Perhaps no one better symbolizes the fundamental role of science within medicine" https://t.co/sBeQbiO3DP @TheLancet's new theme issue is rich with reviews, perspectives https://t.co/wmXbGU4s5I
2022-12-15 23:11:14 T-cell engineering vs cancer has gone to an unprecedented level for when and where cells act, via synthetic circuits @ScienceMagazine https://t.co/84Prp9xDPd https://t.co/ldH6E16bvs Good explainer @Nature https://t.co/F4ttkfQvQ1 Cellular engineering's impact is growing quickly https://t.co/6aXYNxz18I
2022-12-15 20:02:17 What's POTS? Nice demonstration by @ahandvanish https://t.co/mOD0OwLvXw
2022-12-15 19:03:30 What is @ScienceMagazine's Breakthrough of the Year? The James Webb Space Telescope Runners-up include progress in RSV vaccine, the Epstein-Barr virus associated with multiple sclerosis, foundation (creative) models #AI https://t.co/Dp0oiR2txZ https://t.co/98C8bV38WP https://t.co/hesn4Uneg6
2022-12-15 17:22:17 The primary efficacy endpoint--1-sided superiority--was pre-specified in the protocol and analysis plan https://t.co/mGhEBwwARc https://t.co/0NuF6PWi4v
2022-12-15 17:15:02 This week's editorial @Nature on Covid mortality https://t.co/3oX0TxocAX https://t.co/8rzozUQzql
2022-12-15 16:42:50 The broad benefit of SGLT2 inhibitor drugs (sodium/glucose cotransporter 2) in patients heart failure with preserved ejection fraction and symptoms https://t.co/SJsGxIedjt @NatureMedicine today
2022-12-15 15:42:36 What really matters in a crisis: experiments to explore life-and-death situations https://t.co/J9tGaV2DX0 @gordon_hecker @bengurionu https://t.co/kOAi6EP0nK
2022-12-15 15:31:36 For access https://t.co/HJWbrLS5QE
2022-12-15 02:40:58 The Elonathon by @stephanpastis https://t.co/NyMuWgUoxJ
2022-12-15 00:59:49 RT @EricTopol: We've never had medications that can safely achieve ≥20% body weight loss. With over 1 billion people with obesity and >
2022-12-15 00:37:15 Returning to free Covid tests in the US . They'll come in handy with upcoming gatherings, especially with the current wave gaining steam. Ordering starts tomorrow https://t.co/t7GnkZ8Qva
2022-12-14 21:43:32 "Loss of smell and taste during COVID-19 infection are strong predictive factors for a robust immunologic response based on IgG [antibody] titers" https://t.co/2sbGdI1R2G @PLOSOne @ColumbiaOto @ColumbiaMed
2022-12-14 21:23:18 Can an intermittent fasting (IF) diet reverse Type 2 diabetes? A small randomized trial says yes, w/ 47% of IF-assigned participants achieving remission for at least 1 year vs 3% of controls (odds ratio of 31
2022-12-14 21:11:55 All is not quiet on the Asian-Pacific front (besides China) https://t.co/ON6Xhw2DvP
2022-12-14 20:48:39 @LisaAMcCorkell @Nature @yunlong_cao I feel so lucky to have worked with you, @ahandvanish, and @julialmv on the soon to be published #LongCovid review paper in a @NaturePortfolio journal
2022-12-14 20:24:24 @yunlong_cao @Nature @LisaAMcCorkell We are all deeply appreciative of the fine work that you and your colleagues have done to extensively characterize #SARSCoV2 variants , and published the data, well before they declare themselves clinically
2022-12-14 19:04:08 RT @bel10: This is a really positive, hopeful read if you need one today. Actual lasting silver linings of this pandemic have been few and…
2022-12-14 18:48:52 This is what not protecting seniors results in.... Add the BQ.1.1 variant to under-boosting, lack of mitigation factors On the way to exceeding BA.5 variant wave peak https://t.co/axTWPiQjNE
2022-12-14 18:29:58 Impressive work by @Lenka_Dohnal @nitaidean @sellmyerlab @FitzGerald__Lab @PSUmetabolomics @BaurLab @AmberAlhadeff @Helfrich_lab @MaayanLevy_Lab See thread by @ThaissLab Hope they have a @redcube link for those with access issues https://t.co/5G7ByqA1Q5 https://t.co/4XutRKAqmo
2022-12-14 18:20:13 RT @alexnatarosMD: Excellent synopsis of @elonmusk-era #MedTwitter @CMAJ Highlights MDs to “counter &
2022-12-14 18:09:15 Among @Nature's Top 10 people who shaped science in 2022, big congratulations to @yunlong_cao Covid predictor and @LisaAMcCorkell #LongCovid advocate https://t.co/i7KcjWRQMy https://t.co/AMGURebvvy
2022-12-14 16:53:06 "My gut microbiome made me do it" "What?" "Exercise" https://t.co/Ntys1n6RX4 @Nature by @ThaissLab @ChristophThaiss @PennMicro @PennMedicine https://t.co/k3WdHmjOFM @NatureNV @pipethero @GulistanAgirman @UCL @justsaysinmice https://t.co/ijfXtwzcMD
2022-12-14 16:40:47 The deaths from Covid in the first 2 years of the pandemic were nearly 3-fold reported—~15 million globally—by @WHO excess death calculations https://t.co/YwZHD4ufC1 @Nature https://t.co/sE7wVs0tWR
2022-12-14 16:31:57 The distribution and persistence of #SARSCoV2 throughout the body and brain in people who died from Covid https://t.co/plsFOl1QYM @Nature https://t.co/pO8DX3G2jQ
2022-12-14 15:32:28 PML (progressive multifocal leukoencephalopathy) is a rare, dreaded and often fatal brain infection that can occur after immunosuppressant drugs. The potential for screening gene variants to avoid PML is raised here https://t.co/XN9MjUU0Ds https://t.co/CtZSXWtPDa
2022-12-14 15:17:44 Just published @CellCellPress "Alarming antibody evasion properties of rising #SARSCoV2 BQ and XBB subvariants" These are the current US variants to reckon with. Were it not for the immunity wall that's been built, we'd be having a much rougher go at it https://t.co/VqxKpU5ZKu https://t.co/3WjcHL7jPB
2022-12-14 01:30:24 My review of where this is headed, well beyond infectious diseases and cancer. Real pluripotent potential https://t.co/6l2aW15kRF https://t.co/eVrOaQuPXB
2022-12-14 01:26:34 In just 3 weeks using the mRNA platform we've seen: —a universal flu vaccine effective in multiple experimental models https://t.co/CfABwulTzS —1st sign of efficacy in a cancer randomized trial (vs Stage 3/4 melanoma) https://t.co/KtwPrwq9oO https://t.co/LEmljWiqbd
2022-12-13 18:59:15 The ongoing Covid "senior wave" in the United States, already has surpassed the BA.2, BA.5, and soon Delta waves for hospital admissions among people age 70+ https://t.co/Cze8bZxwXr Most admitted have had 2 shots but w/o a booster in >
2022-12-13 15:30:49 Debunking myths on metabolism and daily energy expenditure, especially with respect to age https://t.co/9KQ5IjvpEs by @HermanPontzer @sciam https://t.co/1NhTVcctN9
2022-12-13 14:32:57 @HelenBranswell @WHO @JeremyFarrar @wellcometrust Yes, this is big news. Congratulations @JeremyFarrar for your new post! And to @WHO for recruiting him
2022-12-13 14:15:34 More on this here, by @matthewherper @statnews https://t.co/KtwPrw8yxg and https://t.co/VIbuOauW3Z @FT @JamieSmythF https://t.co/ur9GsUguB9
2022-12-13 12:09:00 The 1st randomized trial of an mRNA cancer vaccine to show efficacy: Stage III/IV melanoma, a combination immunotherapy + vaccine was superior to immunotherapy alone for recurrence-free survival. 157 participants (Phase 2b) w/ large trial planned PR by Moderna &
2022-12-13 02:14:16 RT @FutureDocs: @EricTopol it’s like he wants us all to go but we should not comply
2022-12-13 01:57:06 If the #ScienceTwitter &
2022-12-13 00:09:49 For people with Type 2 diabetes, an open-label randomized trial of a low carb, high fat diet vs hi carb, low fat showed substantial benefits for 6 months that were not sustained during follow-up https://t.co/VsqmlejcE1 @AnnalsofIM @AleksanderKrag @Camilla_Dalby https://t.co/NzN4JyxBHY
2022-12-12 23:52:08 France has withstood the challenge of the BQ.1.1 variant fairly well as the 1st country to see it achieve dominance, an encouraging sign relative to its immune evasiveness @OurWorldInData and https://t.co/kraBgpXvtv https://t.co/LYAzvwikiI
2022-12-12 23:22:10 Significant reduction of hospitalization (by 40%) and deaths (by 70%) among patients who received Paxlovid vs controls in a large US health system (@MassGenBrigham) https://t.co/adjB62nooJ @AnnalsofIM @AnnWoolleyMD @SDrydenPeterson https://t.co/m1NgJXAvBI
2022-12-12 19:46:22 Part of the explanation for why there's a lot of variability for neutralizing antibodies after Covid: genomic variants in the imunoglobulin heavy chain https://t.co/UUvqfOrbfh @ImmunityCP https://t.co/dLm7N5ktWi
2022-12-12 16:50:55 RT @EricTopol: I wrote about the new anti-obesity drugs—semaglutide (Wegovy) and tirzepatide (Mounjaro)—that represent one of the most impo…
2022-12-12 16:47:56 Accompanying editorial by @dysclinic and @ArturFedorowski https://t.co/20gmj51uxv https://t.co/Q9ZFjTBKqR
2022-12-12 16:33:54 Postural orthostatic tachycardia syndrome (POTS) can occur after Covid and in the 90-day period following vaccination. It is 5-fold more common with infection https://t.co/MYMYvt1sOJ @NatureCVR @CedarsSinai https://t.co/PR390ypkET
2022-12-11 20:45:18 "When it comes to protecting seniors, we’re doing a terrible job of that in this country” https://t.co/vGLtcHNLyw by @CarlaKJohnson @laura_ungar @AP @APHealthScience In many states, Covid hospitalizations for people 70+ are higher than during their BA.2 and BA.5 waves https://t.co/ptqvUcngqH
2022-12-11 18:32:11 Why are long-lived lung, tissue-resident memory T cells so important vs Covid ? https://t.co/BOBSmGZrLi @NatRevImmunol Francis Carbone @TheDohertyInst @UniMelb https://t.co/JbYAAli0mV
2022-12-11 17:47:29 We've never had medications that can safely achieve ≥20% body weight loss. With over 1 billion people with obesity and >
2022-12-11 17:08:58 My friend, @UrnovFyodor, a pioneer of genome editing, lays out his vision and deep concerns about "word-processer- like control over DNA" "The invention of CRISPR gene editing gave us remarkable treatment powers, yet no one should do a victory lap." https://t.co/49OwXvP7kg https://t.co/3RV3I37sHl
2022-12-10 20:41:51 I wrote about the new anti-obesity drugs—semaglutide (Wegovy) and tirzepatide (Mounjaro)—that represent one of the most important breakthroughs in medicine https://t.co/SMZO20ExDk
2022-12-10 16:45:42 We're now in the era of spatial biology: it's not only possible but becoming essential to define the spatial process &
2022-12-10 16:26:05 "These observations indicate the need for development of mucosal vaccines to induce potent immune responses at sites where #SARSCoV2 infection occurs." https://t.co/OJQuUipaHi H/T @chrishendel https://t.co/tWhL61J2mu
2022-12-10 15:33:09 Just out @NEJM, a "milestone" The level of neutralizing antibodies induced by Covid vaccines has been established as a correlate of protection, i.e. a surrogate endpoint for predicting clinical outcomes and use for regulatory approvals https://t.co/CLMoASrRnt https://t.co/ZBIIb9rFsM
2022-12-09 18:36:00 RT @davelevitan: Just because this tool is pulling from millions of peer-reviewed papers doesn't make its conclusions true or good. "You…
2022-12-09 18:22:21 Case report of 2 individuals with #SARSCoV2 remnants in penile tissue at 1 month after Covid https://t.co/dYUfJjKQdL https://t.co/3hhgIC1hjJ
2022-12-09 17:27:56 In the same time frame September to now, look at booster uptake in England among 65+ seniors (>
2022-12-09 16:37:30 The GATTACA film 25 years later Its "prescient forewarnings are still relevant today in light of the current trajectory of genomic science and technology." by @dovgreenbaum and @MarkGerstein @NatureGenet https://t.co/0jBNjgwaTP https://t.co/kpn25pUOIN
2022-12-09 16:23:39 —90% of Covid deaths in the US are now in people age 65+ —94% of Americans age 65+ have had 2 shots, but majority with no booster, only 34% with bivalent booster https://t.co/5wOCpbxZO1 @dwallacewells @nytopinion
2022-12-09 15:41:12 Some regional variability for BQ.1.1 https://t.co/qJCk7AaoJ2
2022-12-09 15:41:11 The BQ.1 variants taking over, now ~70% in the US with the BQ.1.1 37%
2022-12-09 04:46:21 @msb1iop @paulg @NatureMedicine @ma_hamer @M_Stamatakis Thanks. I didn't delete anything
2022-12-08 22:03:27 China's elders problem https://t.co/3TcJQYrFul https://t.co/uG4zedUfuK
2022-12-08 21:43:12 Comparison of ChatGPT and AlphaCode https://t.co/QjlEMViyOT
2022-12-08 21:41:13 @richardludlow @NatureMedicine @ma_hamer @M_Stamatakis No cause and effect established or asserted
2022-12-08 19:46:05 RT @hholdenthorp: Enjoyed talking to Tony Fauci about the last few years and what lies ahead. Lots of great stuff in here for science polic…
2022-12-08 19:22:32 No problem, I'll code for you #AlphaCode https://t.co/7m41MgwHUM "This result marks the 1st time an #AI system has performed competitively in programming competitions" @DeepMind @OriolVinyalsML Not so fast. What it can and can't do. https://t.co/lasA1mJK08 by @zicokolter https://t.co/QqRYL14VJh
2022-12-08 18:40:15 Why does having a human cell atlas, with single-cell and spatial definition, have such transformative potential in medicine? https://t.co/l1II0q1was by @jennyErood @AidMaart @teichlab @GraphicAnja Aviv Regev @NatureMedicine https://t.co/0ZSvKnYaMg
2022-12-08 18:29:52 @JeremyKonyndyk Thanks Jeremy!
2022-12-08 17:36:09 1 vs 3 , a 3-fer https://t.co/ik98DuHT76 by @AlexLJanin w/ @dr_kkjetelina https://t.co/jZnusaUtxA @taraparkerpope @FenitN https://t.co/MyRvFSqD2G
2022-12-08 16:51:44 The conclusion is worth reviewing —1 minute bursts, 3 to 4 per day —for non-exercisers, there's hope —these finding only possible via ~25,000 people from @uk_biobank, wearable sensors, and #AI analytics —1st research to measure VILPA effects https://t.co/ECoOUmaaOo
2022-12-08 16:45:19 @paulg @NatureMedicine @ma_hamer @M_Stamatakis Yes, correct. 1 minute bursts made a difference, 3-4 per of these per day associated with the protection
2022-12-08 16:34:59 Vigorous intermittent lifestyle physical activity (VILPA), 3-4 minute bursts per day, associated with ~40% reduction of all-cause mortality, cancer and cardiovascular mortality https://t.co/BoGmigjqWl @NatureMedicine @ma_hamer @M_Stamatakis https://t.co/UPx61oh4Gs
2022-12-08 16:19:41 Subsequent development of #LongCovid detected by gene expression during acute infection. Two different patterns related to antibody production to spike protein https://t.co/ZklAmwyk4L @NatureMedicine @noambeckmann1 @IcahnMountSinai https://t.co/7uklWADq7e
2022-12-08 15:18:00 RT @Yale: PODCAST: @thehowie and @hmkyale are joined by Dr. Eric Topol, a physician and writer to discuss his career turn toward genomics a…
2022-12-08 13:00:00 CAFIAC FIX
2022-12-07 08:00:00 CAFIAC FIX
2022-11-13 23:12:39 @DrAhmedKalebi @washingtonpost Hope so!
2022-11-13 22:29:15 RT @pnatarajanmd: .@EricTopol discusses the exciting advances in more cost-efficient timely clinical while genome sequencing. Uniquely, the…
2022-11-13 21:11:24 @DeAnnGlobalHea1 @washingtonpost @PostOpinions I do the best that I can with the data that are (or when they are) availablehttps://t.co/DzBiZvrXBN
2022-11-13 21:06:43 I'm getting criticized for not highlighting more parts of the editorial. Here's the updated highlighted version https://t.co/zMgnTgISos
2022-11-13 20:54:07 I liked Michael Lewis's book a lot more https://t.co/QtrUJzxjlf
2022-11-13 20:30:13 Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so much attention has been on the lowering of cost, [sample ->
2022-11-13 17:03:30 @Mssarahmssarah @washingtonpost @PostOpinions Sure. I could have highlighted every word—it was that good
2022-11-13 16:51:54 Thanks for the mention/linkhttps://t.co/yEQ6h5f4KW
2022-11-13 16:51:53 Excellent, pitch perfect editorial on the new variants and current status of the pandemic, by @washingtonpost editorial board todayhttps://t.co/zdU2fPCTpJ @PostOpinions https://t.co/CmrSN3RsyW
2022-11-13 15:35:13 My friend @LCalabreseDO, a leading rheumatologist, relates his own experience with #LongCovidhttps://t.co/spHlV61gAg @HealioRheum https://t.co/dpqnJ7Gi5X
2022-11-13 02:17:15 Nevada. Winner Catherine-Cortez MastoSenate retained control to Democrats just now
2022-11-12 23:37:46 @nlj @OurWorldInData That's right and I stand by it. If Omicron had not arrived, the pandemic would have been over after Delta.My statement was very clear: "If there's not a worse than Delta...." And there was. Period.
2022-11-12 23:32:57 The same applies to excess mortality for the world.Yet so many people are unreceptive to any good news https://t.co/6X15RMUv0W
2022-11-12 17:44:15 Another review of @DrSidMukherjee's Song of the Cell, one of the best books this year@nytimesbooks by @jenszalai https://t.co/yLFzOpT539 https://t.co/NUGLG1FEEB https://t.co/iyHkq6644o
2022-11-12 16:18:29 Good to seeNear pandemic low and trending lower by log-plot@OurWorldInData https://t.co/zENBw9dnAW
2022-11-12 16:03:21 Covid has been associated with an increased risk of both Type 1 (autoimmune) and Type 2 diabetes, but there are many unresolved questions. A good perspective piece @NatMetabolism https://t.co/d1cnHGukq8 https://t.co/3bYG7uLvPz
2022-11-11 23:06:07 @chrischirp good to see this!
2022-11-11 17:43:13 @mlipsitch Agree with your point, Marc, but disagree that vaccines provide adequate/durable protection vs symptomatic (re-)infections. That was true through Delta but there's been marked erosion of that protection since Omicron in late 2021 and its descendants
2022-11-11 16:57:58 What is encouraging is that New York State, the highest BQ.1.1% in the US still shows no sign of increased Covid hospitalizations. Same for the US overall https://t.co/fGkw5lysLP
2022-11-11 16:49:00 A simplified map of human metabolic pathways
2022-11-11 15:55:31 New US Covid genomics: the BQ.1 variants have risen to account for 44% of cases, with BQ.1.1 at 24% (18% a week ago), as BA.5 rapidly fades. BN.1 shows some increasehttps://t.co/jjl2AnOYb5 https://t.co/94vLZ04aXA
2022-11-11 15:25:02 A new first-rate review of how the mRNA-nanoparticle platform is moving in clinical trials of infectious diseases, cancer, protein therapy and genome editing. And the many innovations in storehttps://t.co/esvgsHWF9y @NatureMedicine https://t.co/F2gYQgMRrL
2022-11-11 15:04:07 RT @EricTopol: The daily pandemic briefing Ground Truths today is on 2 publications regarding Covid reinfections and #LongCovid https://t.…
2022-11-11 02:58:10 @ValdaVinson @hholdenthorp @oooitsplasma @hoelza She’s the best life science graphic artist!
2022-11-11 01:31:36 The daily pandemic briefing Ground Truths today is on 2 publications regarding Covid reinfections and #LongCovid https://t.co/QyJtagZamT
2022-11-10 23:00:44 RT @larrybrilliant: No one knows if this winter will see a surge, a wave, or a flat and even decreasing level of cases and deaths from COV…
2022-11-10 22:32:39 New @SciImmunology —Covid vaccines neutralizing activity is almost entirely to S1 subunit of the spike—2-P substitution works well to nAbs, 6-P would likely be better—Better vaccines can and should be madehttps://t.co/u0TBY4KXBU by @veeslerlab
2022-11-10 22:23:33 The best review of tissue macrophage cells—critical for both preserving health and their role in many diseases—that I've seenhttps://t.co/5brtq516qI @CellCellPress @MiriamMerad @SinaiImmunol @park_mstreet @AymericSilvin @FGinhoux @SinaiMSTP https://t.co/FetlDBc74X
2022-11-10 19:24:51 New report from Germany of a large matched-control #LongCovid study of 157,000 people w/Covid, including ~12,000 children and adolescents"The results of the present study indicate that post-Covid-19 cannot be dismissed among children and adolescents."https://t.co/JvNgibLw21 https://t.co/sryOmAY4uI
2022-11-10 18:07:18 RT @EricTopol: Today's Ground Truths, pandemic briefing, on booster waning, brain fog with #LongCovid, and potential of Paxlovid resistance…
2022-11-10 18:00:58 Documenting #SARSCoV2 evolution in deer and a deer-to-human transmissionhttps://t.co/jlMwOcIvOj @NatureMicrobiol by @jeffcbowman @SMubareka and colleagues @UofTEPIC @UofT
2022-11-10 16:58:19 Vaccine status was not protective vs reinfection sequelae, which is why we need nasal vaccines to achieve mucosal immunity, limit infections, reinfections, and spread. Since the arrival of Omicron, we've seen limited (effectiveness &
2022-11-10 16:38:34 Just published @Nature 1st #CRISPR genome editing of immune T-cells to treat cancer, individualized for 16 patients with solid tumors, with some successhttps://t.co/vaAtFm43nbhttps://t.co/HFaQLyi6rkby @heidiledford https://t.co/ymkxkx6HaS
2022-11-10 16:16:36 All-cause mortality, hospitalizations and adverse sequelae are increased by reinfection, not just in the acute phase but during 6 month follow up https://t.co/6Uulb3fxGa
2022-11-10 16:16:34 Graphic of adverse outcomes by number of infections, a dose-response relationship https://t.co/mmM9zA9sn5
2022-11-10 16:11:29 Covid reinfections are bad for your health. Big @DeptVetAffairs study published @NatureMedicine today. #LongCovidhttps://t.co/1ZMbAnolSiby @zalaly and colleagues https://t.co/OXD2uGpVZ1
2022-11-10 01:43:56 Today's Ground Truths, pandemic briefing, on booster waning, brain fog with #LongCovid, and potential of Paxlovid resistancehttps://t.co/qMi0fhXEOJ
2022-11-10 00:36:28 The 4th shot (2nd booster) induced a good, sustained neutralizing antibody response but its protection vs infection was less durable (lasting ~3 months) than the 3rd shothttps://t.co/6sAPJvJAR6 @NEJM https://t.co/TavoVpkfVb
2022-11-09 22:27:52 The mechanism of brain fog with #LongCovid (and potential biomarker, CCL11) after a mild casehttps://t.co/8k2O8EA3xn @VarunVenkatara2 https://t.co/webMwfeVzF @CellCellPress @Franklandlab https://t.co/NQAgabJntg
2022-11-09 22:18:35 Evidence for benefit of masking in schools when the universal policy was rescindedhttps://t.co/c2evJWVm5v @NEJM @ToriCowger @KTHallPhDMPHeditorial https://t.co/WBm16es4gj by @JuliaRaifman @Tiffany_L_Green https://t.co/R7Wv10jxWM
2022-11-09 22:06:28 A triumph of successful in utero (fetal) treatment of Pompe's disease, a rare fatal genetic conditionhttps://t.co/5W1UdBbI78 @NEJM https://t.co/uZjb9Wt3U4
2022-11-09 19:20:00 3 important #cancer papers today1. Spatial genomicshttps://t.co/sr50tvUYac@nature2. Cancer vaccineshttps://t.co/37L9NSzrYr @ScienceTM3. Engineering immune cells (CAR-T) for Rxhttps://t.co/syPpYN8lUr @ScienceTM https://t.co/FvAr8lfWKX
2022-11-09 18:11:39 "We thus identified a recovery-organizing neuronal subpopulation that is necessary and sufficient to regain walking after paralysis"Restoration of walking capability in 9 patients with spinal cord injuryhttps://t.co/Jr8FepTreohttps://t.co/1tsvSyfQH6@Nature @EPFL_en @gcourtine https://t.co/Fm8xtZag3V
2022-11-09 16:37:42 Can Calmodulin gene variants exonerate "Australia's worst female serial killer"?https://t.co/IipS3z4oRO@nature by @nickyphillips_ https://t.co/6owJ75e6f0
2022-11-09 16:27:41 In pregnancy, a 10-fold higher #SARSCoV2 antibody from vaccine compared with Covid infections and enhanced protection for the newbornhttps://t.co/5Q3xzq6Q4Q @JAMANetworkOpen @dus10flan @ChildrensPhila @karen_puopolo @PennMedicine
2022-11-09 15:43:51 A new review of how mRNA vaccines work and the multiple ways the mRNA-nanoparticle platform can be improved to be more effective with less side effects (that is hardly being pursued)https://t.co/Wik2hH2pLN @ImmunityCP by @rein_verbeke and colleagues https://t.co/qXIjXzYOnd
2022-11-09 04:13:35 Polls. Schmolls.Again
2022-11-09 03:09:53 RT @mehdirhasan: Covid didn’t even get a mention in these midterms. Absolutely crazy.
2022-11-08 22:08:53 https://t.co/wbWEtix2s5
2022-11-08 19:03:24 @Agtgtwn Many thanks!
2022-11-08 18:53:36 @bbdd333 yes https://t.co/2dcaYJqbVF
2022-11-08 18:51:13 RT @jrfunke: Good news: "This uncoupling of lab assays of immune escape vs a benign clinical outlook is the first we have seen in the pande…
2022-11-08 16:51:04 RT @EricTopol: The reasons I think it's essential for #ScienceTwitter and #MedTwitter to stay with @Twitter right now—Spread the truth/fac…
2022-11-08 16:28:55 A brilliant review of the role of immunity in Alzheimer's disease and its potential as a target for therapyhttps://t.co/aZXEDZVYRtby @xiaoyingchen36 @holtzman4 @WUSTLmed @ImmunityCP @WUADRC https://t.co/edCSx5kE1D
2022-11-08 15:16:05 The impact of #LongCovid on the American workforcePersistent loss of ~500,000 workers"A mass disabling event"—@Cutler_econ https://t.co/PxnX3S69nS by @sinoceros @laurenweberWSJ https://t.co/ID1GlOQVBJ
2022-11-08 14:56:54 RT @EricTopol: An optimistic outlook (with caveats)My daily pandemic briefing, #6https://t.co/yEQ6h5f4KW If you find these useful, please…
2022-11-08 05:21:07 @DrJayneMorgan Thank you!
2022-11-08 03:56:36 @rquiroga777 Noted and thanks for pointing this out. Time will tell on the BQ.1.1x
2022-11-08 03:31:45 @iaincheeseman @StearnsLab @BlaineyLab @lukebfunk @WhiteheadInst @broadinstitute @CellCellPress Sorry on the misspelling, Iain. What a remarkable resource you and your colleagues published today
2022-11-08 02:02:31 @vaccinate Much appreciated!
2022-11-08 01:55:57 An optimistic outlook (with caveats)My daily pandemic briefing, #6https://t.co/yEQ6h5f4KW If you find these useful, please subscribe and share. They are free and always will be.
2022-11-07 22:03:42 How to determine all the essential human genes?Analyze >
2022-11-07 20:39:49 The prolonged recovery of consciousness in some patients with severe Covid is unusual. The brain state and pattern resembles the painted turtle and may be protective https://t.co/nFrLle1l4L @PNASNews https://t.co/iLVbiS1m9y @NYTScience @carlzimmer https://t.co/JbtKcSa4FO
2022-11-07 17:01:39 So you want to take down all the β-coronaviruses?Yet another path to broadly neutralizing antibodies as a template for variant-proof vaccines—the stem helixhttps://t.co/NkBfjUstbz @cellhostmicrobe @NIAIDNews @scrippsresearch https://t.co/b1SiuRtmiG
2022-11-07 16:06:21 As the BQ.1.1 threat fades in France (the bellwether), it's a preliminary good omen for the holiday season that we won't be facing a major waveAdd to this: the bivalent booster induces some cross-immunity protection vs BQ.1.1 &
2022-11-07 15:09:33 RT @EricTopol: The first study to show improvement in long-term outcomes after Paxlovid—including less #LongCovid, deaths, hospitalizations…
2022-11-07 01:35:00 We haven't had a treatment for Lp(a), a well known risk factor for heart disease. We may now. https://t.co/E8TAfp5coE #AHA2022 @NEJM @DrM_ODonoghue@marcsabatine @TIMIStudyGroup @Brighamw https://t.co/hJICTPq4MQ
2022-11-07 01:27:42 @dralicehan Thank you!
2022-11-07 00:37:56 Consistent and significant reduction of #LongCovid with Paxlovid treatment across all subgroups including age, sex, race, risk factors, prior Covid, vaccination, booster, unvaccinated https://t.co/T0oGWhfaTS
2022-11-06 18:31:46 Kudos to my friend @MollyJongFast! https://t.co/qSp7S0IKkV https://t.co/5ayJzD0H7d
2022-11-06 18:23:28 @JReinerMD https://t.co/z68bDAQuhi
2022-11-06 18:07:24 The first study to show improvement in long-term outcomes after Paxlovid—including less #LongCovid, deaths, hospitalizations and complications—is a major advance. I've reviewed and contextualized it herehttps://t.co/bugfFk44sh
2022-11-06 15:31:37 The mean age of the participants in this study was 65.In the US, people age 70+ are the least likely to receive Paxlovid (missing out on acute phase benefit) https://t.co/5GuZG9BTwt
2022-11-06 14:32:46 That’s reduction (not reception)The further divergence of deaths and hospitalizations after the acute phase is notable
2022-11-06 04:23:52 @DocJeffD Thanks!
2022-11-06 04:23:27 The reception of #LongCovid and severe outcomes in the post-acute phase, associated with paxlovid treatment, was independent of vaccination, booster, prior infection or unvaccinated status https://t.co/Ivrdq4C701
2022-11-06 03:20:41 Breakdown of reduction by system and symptoms associated with Paxlovid vs controls https://t.co/4soa5duMyi
2022-11-06 03:13:37 Divergence of curves for reduction of #LongCovid https://t.co/DthdD50HMs
2022-11-06 03:06:58 Important new preprint just posted from @zalaly and colleagues
2022-11-05 17:21:53 RT @EricTopol: How #AI is transforming human embryo selection and improving in vitro fertilization. A renaissance in reproductive medicine…
2022-11-05 15:56:47 It's a good sign when you add 3 convergent mutations to BA.5's spike, have multiple lab assays showing much more antibody evasion for BQ.1.1, but we don't see any clinical sequelae (yet)Mutation map via @PeacockFlu More on this herehttps://t.co/8ikz6ZDm26 https://t.co/HUQZz3L7Y1
2022-11-05 15:20:41 Dr. Ozby @DrewSheneman https://t.co/X1ZypOJhlO
2022-11-05 01:43:11 @DennisOwen @Twitter Much appreciated
2022-11-05 01:42:01 @wudanyan Thank you!
2022-11-05 01:30:19 A note of optimism to end the weekhttps://t.co/8ikz6ZDm26
2022-11-04 23:46:49 https://t.co/fjSTg9HIvi
2022-11-04 21:14:40 @cookyscan1 @RSNA @RadiologyEditor @cekahn @luker_md @arosenkrantzmd @ReedDunnick @ruthcarlosmd @DrLindaMoy @Abbara_UTSW Thanks @DavidBluemke @RadiologyEditor @RSNA for inviting me and I throughly enjoyed our discussion
2022-11-04 21:09:30 Europe hasn't look this good for new Covid hospital admissions for some time @OurWorldInData https://t.co/4Dm88BVF5C
2022-11-04 20:41:01 Will be staying and posting @twitter for nowAlso set up here at MastodonAnd will continue posting daily (brief) pandemic updateshttps://t.co/YllXW9J82kUntil this all gets sorted out https://t.co/SWDINcV5AY
2022-11-04 17:30:04 More on current BQ.1.1 variant status and outcomes in FranceGood thread by @nicolasberrod https://t.co/kwVYa0HIlB https://t.co/swbzAWzW2S
2022-11-04 16:32:12 We now have 6 studies of the bivalent BA.5 booster->
2022-11-04 16:20:33 New York State has >
2022-11-04 16:01:28 New US CDC Covid genomicsBQ.1.1 now 19%, showing most growth advantage vs other variants (with BQ.1 combined ~35% of new cases)https://t.co/jjl2AnOYb5 https://t.co/5gecIINrcm
2022-11-04 14:34:13 How #AI is transforming human embryo selection and improving in vitro fertilization. A renaissance in reproductive medicineOur latest @TheLancet digital medicine essayw/ @MrHadiShafiee https://t.co/W2Vc7iLglB https://t.co/mIRbfRvvsR
2022-11-04 13:28:48 Here are the data presentedhttps://t.co/RRhBYPPAUsAs seen by the Table above of the 5 recent bivalent reports, importance of live virus assay needs to be underscored.Also looks good from that standpoint vs BQ.1.1 https://t.co/DpPx7zFjbs
2022-11-04 13:12:00 More on the results, why 4-fold increase is very good, augmented response seen in people age 55+https://t.co/GkKlYHJnLd by @HelenBranswell @STATnews w/ @florian_krammer (excerpt below) https://t.co/VvnxPUyv8w
2022-11-04 10:45:00 Pfizer BA.5 bivalent booster data just presented by company press release, live virus assay:Compared w/ original booster, 4-fold increase neutralizing Abs vs BA.5 at 1 month Results very similar to @SutharLab below and very encouraging https://t.co/RH2G5NZ9lL
2022-11-04 02:38:35 Even @Oprah (who made Dr. Oz's TV career) knows https://t.co/FVgH89kc27 https://t.co/UiBTCYYOUn
2022-11-04 01:54:29 Can we extrapolate the outcomes in France to the United States if BQ.1.1* proceeds here to dominance?Perhaps, but there is a major gap in vaccination and boosters favoring France https://t.co/BbZ3bkcg1h
2022-11-04 01:09:06 Correcting the Table (Shi study used a live, chimeric virus). Thanks @florian_krammer for noting https://t.co/QF6uUznCzF
2022-11-03 22:32:21 The BQ.1.1 variant's marked immune evasion in the lab is not playing out clinically to date. It is dominant (>
2022-11-03 21:27:15 Why are males predisposed to viral and vaccine-induced myocarditis?https://t.co/jJpekAAkPw @ScienceTM @SeanM_Wuvery likely steroid signaling mediated, lessons from immune-checkpoint inhibitor myocarditis https://t.co/n7pp7p3ZfI
2022-11-03 20:13:37 Special section @ScienceMagazine new issueOur interconnected brain with its ~86 billion neurons (and ~10,000 synapses with each one) when working well is a "synchronized symphony" with aesthetic featureshttps://t.co/8LEomFfvjS https://t.co/Cltl3MJSSp
2022-11-03 18:16:56 Two new reports @PLOSGenetics on genomic susceptibility or protection from severe Covid1. A risk gene (TYK2) variant for lupus is protectivehttps://t.co/lmU3YYzLDU2. 5-fold increased risk of a rare TLR7 variant https://t.co/ZWi7hf9LaB
2022-11-03 17:06:46 It has taken 3 decades and a pandemic to actualize mRNA as a therapeutic platform, and now, with attention to improving efficiency/delivery, the potential applications are remarkably broadA new outstanding reviewhttps://t.co/ta3x0ZffEm@NatureBiotech https://t.co/LUgzWijRug
2022-11-03 14:47:21 The marked propensity for blood clots with severe Covid: antibodies to platelet factor 4 likely a contributorhttps://t.co/7grOoRnJxg @PNASNews @NIAIDNews https://t.co/Tf01jttH3n
2022-11-03 03:18:43 Summary of the 5 bivalent booster reportshttps://t.co/RDydfv4MlD https://t.co/OIOmumKgDR
2022-11-03 00:56:02 In it is a summary of the now 5 bivalent booster reports that compare its immune response (neutralizing antibodies) with the original booster. And vs the BQ.1.1 variant. https://t.co/KHTtZxw0cD
2022-11-02 23:29:22 Today's brief pandemic updatehttps://t.co/RDydfuNaX3
2022-11-02 21:59:19 A 5th report on the bivalent booster vs BQ.1.1 today reinforces the high level of immune evasion of this variant, with minimal difference for the bivalent ->
2022-11-02 21:50:48 A new, fourth assessment of the BA.5 bivalent booster showed augmented neutralizing antibody response to BA.5 compared to the original, but lacking a robust response to BQ.1.1, XBB and BA.2.75.2https://t.co/HUPkDil40v https://t.co/TEmivAXvhW https://t.co/j8qBPDERG1
2022-11-02 21:05:00 Real world mRNA vaccine effectiveness in children and teens, vs Omicron infections, Qatar https://t.co/puXbEE1tDqjust published @NEJM by @HChemaitelly @Laith_AbuRaddad and colleagues https://t.co/g97JwNe9jc
2022-11-02 20:40:26 @EladSharonMD @drorsos That’s right
2022-11-02 19:42:24 How #AI can unravel cellular immunity https://t.co/H6TBbz1Mn9 @ScienceAdvances @BerendSnijder @snijderlab @BenHale89559171 @ETH_en @IMSB_ETH https://t.co/LzAj2dlWUf
2022-11-02 19:25:06 For sepsis, quantifying immune dysfunction via whole blood RNA-seq or microarray led to accurate prediction of clinical outcomes across pathogens (including Covid) and age groups https://t.co/JkRq6w6soC #AI @ScienceTM @KnightGenetics @NDMOxford @OxfordMedSci @eddiecg https://t.co/ovfe8bJh9s
2022-11-02 18:20:18 RT @GaviSeth: A great graph. We are in a renaissance of Vaccinology. I can’t wait to see what new breakthroughs science will bring!
2022-11-02 18:16:34 LinksHo https://t.co/QT5emKL881Barouchhttps://t.co/j8XNrYTaomSutharhttps://t.co/... here:https://t.co/IOVczxd0fM
2022-11-02 18:16:33 There have been 3 bivalent booster reports w/ different results. Why?—Suthar lab used live virus, others pseudovirus—There was v small advantage (vs monovalent) for BA.5 nAbs (&
2022-11-02 17:30:16 Progress: an update of @MaxCRoser's @OurWorldInData famous graph that showed the hyper-accelerated Covid vaccine success, but many pathogens without a vaccine. Good news now for RSV (1st identified in 1956) and others with promising clinical trial data () https://t.co/6k9cy0vygd
2022-11-02 16:25:06 Impact of the rollout of an inhalable Covid vaccine in Chinahttps://t.co/okFulwr2Fr @FT @cansinobio_inc by @EleanorOlcott @WillLangley96 Yet nasal or oral vaccines get no priority or dedicated funding in the United States https://t.co/9ew7dS5X1G
2022-11-02 16:11:22 This reflect the immune evasion posed by BA.5 and replicates a few previous reports, such as this one (for age 18+).Also reinforces the waning immunity over time and reliance on boosters to maintain high level of protection https://t.co/J4fXDu3AaI
2022-11-02 16:01:58 Within the United States, the BQ.1.1 variant is highest in New York (not dominant yet), so this is good to seehttps://t.co/CbsSRbB6mz https://t.co/2NGiKfvZzn
2022-11-02 14:42:10 The new data for the bivalent booster's broadening of immune response against the BQ.1.1 variant, summarized, in context with a new paper that frames the impact of boostershttps://t.co/IOVczxuB7k
2022-11-02 14:34:31 Condensates, the peculiar shape-shifting blob droplets inside cells, are being targeted for cancer and neurodegenerative diseases, among other conditionsA @Nature feature by @ElieDolgin https://t.co/1PZA3EnSbH https://t.co/pneNmUUwrl
2022-11-02 14:27:21 Confirmation of some loss of protection of vaccines/boosters vs hospitalizations and deaths in the BA.5 wave, age 50+, Ontario, Canadahttps://t.co/ycnwmaDveZ @DrJeffKwong @ICESOntario @PublicHealthON @UofT https://t.co/PyMY7YR2eU
2022-11-02 01:20:32 @SuzBrockmann Thank you!
2022-11-01 23:18:59 @SolliesSurgery Read on
2022-11-01 22:41:32 Here's my Ground Truths daily/frequent brief pandemic update for todayhttps://t.co/IOVczxdy5kIt's free. Subscriptions tell me that it's helpful.
2022-11-01 22:11:53 Some good news for the BA.5 bivalent booster Immune response protection vs BQ.1.1 and BA.2.75.2https://t.co/t08KNiBCKY @SutharLab live virus neutralization assay indicates broadened humoral immunity vs new Omicron subvariants (and neutralization >
2022-11-01 19:57:33 RT @ScrippsRTI: “With so many millions of people impaired, the need for accelerating clinical trials with promising immune-system-modulatin…
2022-11-01 18:49:35 I can remember the days when $1 billion/year for a pharma product was considered a blockbuster. Now Pfizer has 2—$34 billion for vaccines and $22 billion for Paxlovid—and they're markedly raising prices of the former "to offset weaker demand"https://t.co/aiCcxGPbtj @JamieSmythF https://t.co/GDoIKVARxS
2022-11-01 18:03:03 @LieslMcconchie @NatureComms @Lucie_Bernard_R @CadwellLab @YaleIBIO @VirusesImmunity Thanks. I plan to briefly cover that topic in my daily update later today https://t.co/YllXWa0b4k
2022-11-01 18:01:02 On the BQ.1.1* and XBB* variant growth, these are the main countries to watch for now https://t.co/UwC8lrswjgIt's early but encouraging to see lack of adverse outcomes so far. More here: https://t.co/UFnDH2Ydwf https://t.co/quIOcIDeaI
2022-11-01 17:50:04 Not enthusiastic about daily or twice daily nasal sprays. Where are the nasal vaccines?https://t.co/eEipWNPNo5
2022-11-01 16:43:13 Some further potential evidence for immune imprinting from a nationwide Qatar study on vaccination, with or without a booster, for protection from Omicron -raddadreinfectionhttps://t.co/qEQm2vTwq4 @HChemaitelly @Laith_AbuRaddad and colleagues https://t.co/zQe0ceataU
2022-11-01 16:26:59 The gut-to-brain axis precise mechanism for how food poisoning and chemotherapies induce nausea and vomiting https://t.co/YyUG2CxY0A @CellCellPress @Tsinghua_Uni https://t.co/POLgCSiO1S
2022-11-01 15:34:42 Just published @SciImmunology The immune response gained from booster shots is largely confined to neutralizing antibodies (nAbs), not T-cellshttps://t.co/G8kB5jB1pT by @LabWalz @YMaringer and colleagues Which links the importance of nAbs to protection vs severe Covid https://t.co/ilIIP82G5D
2022-11-01 15:14:24 Beyond Covid treatments aimed at the virus, there's interest (and FDA approved drugs that can be repurposed) in targeting human protein kinases. And concerns.https://t.co/tZQbUhKGg1 @PostHealthSci https://t.co/Yxhg2TyuNH @scisignal @Tomer_M_Yaron @BrookHeaton5 @heatonlab https://t.co/9IlnmZd32h
2022-11-01 14:53:39 Covid infections disrupt the gut microbiome and increase vulnerability to secondary bloodstream infectionshttps://t.co/OMunSh31Xi@NatureComms @Lucie_Bernard_R @CadwellLab @YaleIBIO @VirusesImmunity https://t.co/7OT2okLeMj
2022-11-01 03:44:45 @mariat444 @Twitter @SubstackInc Will continue to post on Twitter unless or until it becomes unbearable. For the 5 reasons I outlined
2022-11-01 01:09:13 Nevertheless....https://t.co/tKVt1n6zXo
2022-11-01 00:35:20 With @twitter's turbulence, I've decided to post a daily/ frequent brief pandemic update @SubstackInc, beyond the ones I do on biomedicine, #AI, &
2022-10-31 21:26:59 In these uncaring times, do we [physicians] really care? by @BobDohertyDC, former SVP @ACPinternists https://t.co/frOfMQUGtZ @AnnalsofIM https://t.co/UUOnx5HSIL
2022-10-31 18:02:47 @steveagee OK, then here you go, from @dfocosi https://t.co/i6InalnmHS
2022-10-31 17:48:50 Good graphic to simplify what's going onhttps://t.co/M95l9q0bkj
2022-10-31 17:43:34 If you didn't like BQ.1.1's immune escape profile, then you really won't like BQ.1.1.10 and likewise for XBB add- on mutations (or BA.4.6.3, CH.1.1) https://t.co/IHIKgppPc4
2022-10-31 16:49:49 Good question. There's no good excuse why the US isn't aggressively pursuing thishttps://t.co/KkUyGYW9Ei @TIMEHealth by @AliceParkNY w/ @VirusesImmunity @CEPIvaccines @DrRHatchett @cansinobio_inc @BharatBiotech @NIAIDNews
2022-10-31 16:42:13 3. Overcoming bias of self-assembling peptide selectionhttps://t.co/HT0yd38vnU @NatureChemistry @argonne @TroyDLoeffler and colleagues https://t.co/I3IwvFCuUZ
2022-10-31 16:42:11 2. Unsupervised learning of multi-omic microscopic imaginghttps://t.co/a24GkwGUsTby @junbum_kim @afrendeiro @ElementoLab https://t.co/G62clj5FL5
2022-10-31 16:42:09 3 very good #AI papers today1. Graph neural networks #AI for biomedicine and #healthcarehttps://t.co/l5fHAbfNjV by @_michellemli @KexinHuang5 @marinkazitnik @natBME @broadinstitute @harvard_data https://t.co/3RqIbv2bR1
2022-10-31 14:39:01 No, that won't work :-) https://t.co/CPcBb9rViG
2022-10-31 14:08:21 The new variants with marked immune evasive properties are quickly picking up additional mutations. Important thread summary of a preprint just posted. https://t.co/RZofy5MNj6
2022-10-30 19:19:05 @MaskingForAll @Twitter Thank you. I do have a substack and will keep up with posts every couple of weeks or more frequently as warrantedhttps://t.co/YllXWa0b4k
2022-10-30 18:46:21 @morganstephensa What a great chapter and summary you put together https://t.co/fFhqwapn0L
2022-10-30 18:39:07 Graphs are the most recent data posted by @CDCgov https://t.co/HGyjNwCm0v
2022-10-30 18:36:14 The reasons I think it's essential for #ScienceTwitter and #MedTwitter to stay with @Twitter right now—Spread the truth/facts/good info—Counter &
2022-10-30 18:19:39 What if you had something that decreased death by >
2022-10-30 16:55:30 @theheatherhogan @fi_lowenstein @LisaAMcCorkell @priyakamal @chiluvs1 @dunkindona @karlitaliliana @PutrinoLab @WildNycgirl @VirusesImmunity your great chapter on dysautonomia
2022-10-30 16:49:47 What a remarkable #LongCovid info resource by 20 long-haulers &
2022-10-29 19:05:35 The #1 sleuth of life science data manipulation and imaging fraud, @MicrobiomDigest, has analyzed more than 100,000 papers since 2014. She reviews what she's learned and lays out what needs to change https://t.co/AYjYeVcrTP@nytopinion https://t.co/gw75OwQZb7
2022-10-29 17:49:56 @DrSidMukherjee Thinking back. Funny that I reviewed The Gene in Cellhttps://t.co/PYMcpbr1zj https://t.co/fYcV8huFOV
2022-10-29 17:27:33 Q—Before the pandemic, when was the last time an intervention's efficacy and safety was validated in >
2022-10-29 16:27:22 Song of the Cell, @DrSidMukherjee's new book, is an extraordinary work that covers the cell's history and future, along with its mysteries, like he did for genes in The Gene. Reviewed by @DShaywitz @WSJhttps://t.co/ec8WVRk0T6 https://t.co/YUSxRINVEb
2022-10-29 15:25:57 A ranking of the immune evasion for the new variantshttps://t.co/1lrjUMGa9X
2022-10-29 15:21:45 Good summary of the variant swarm/soup status @nature by @ewencallaway with @CorneliusRoemer @yunlong_cao https://t.co/wNwFgdLkvC https://t.co/jvAaShLJqh
2022-10-29 15:15:15 An encouraging sign for one of the (if not the) most immune evasive new variantsXBB is dominant in India and Bangladesh without a rise in cases or deaths to datehttps://t.co/kraBgpFU4V and @OurWorldInData https://t.co/oZdLOXtoSI
2022-10-28 19:37:55 Long-lived plasma cells: real time, cell-by-cell time stamping of their immune response after vaccinationhttps://t.co/bKWGL3a5rp half-life of ~700 days in the mouse model @SciImmunology @MonashUni https://t.co/vRFXcnB8Jy
2022-10-28 18:50:00 Billion-dollar experiments to "escape scientific stagnation"https://t.co/t9uGywZXnS https://t.co/fhmXKtENt6
2022-10-28 17:21:41 @uche_blackstock I'm not going anywhere, Uché. That's how I first met you
2022-10-28 17:18:01 @Nate_DiCamillo @CellCellPress unlocking the article https://t.co/8OakGeNT0I
2022-10-28 17:08:59 The case for some vigorous physical activity: association with reduced mortality, heart disease and cancer in ~72,000 people, mean age 63, followed ~6 yearshttps://t.co/h6XY9Cqms4@ESC_Journals @uk_biobank @Matthew_Ahmadi_ @M_Stamatakis https://t.co/pzYJf68EsU
2022-10-28 16:54:42 "Compelling evidence for the role of carboxylic acid in guiding the mosquito's preference toward specific people"https://t.co/wredsoM8ux @CellCellPress https://t.co/EvMS4VES25
2022-10-28 16:32:26 via @chrischirp In England, the share of cases (and spurt) of BQ.1.1 and BQ.1 is similar to the USHospital admissions are currently on the way down (for now at least) https://t.co/FmfnifCxAT
2022-10-28 15:17:45 @ACPinternists @scrippsresearch Thanks @ACPinternists!
2022-10-28 15:15:25 Besides the hopeful sign from France noted yesterday https://t.co/I4ujEQvJgw Region 2 of the US has the highest BQ.1.1/1, particularly New York, where new hospital admits have not shown a recent rise https://t.co/rcWUlpd8dk
2022-10-28 14:55:38 New US Covid genomics: BQ.1.1 and BQ.1 variants now account for 27% of cases, up from 17% a week ago, on a path to be dominant (>
2022-10-27 22:28:59 On a related front, metabolites from a specific gut microbiome bacterium in people with inflammatory bowel disease can promote tumor developmenthttps://t.co/6NNwlJvWmMhttps://t.co/hPXcuOt3ID https://t.co/72VEts7Soa
2022-10-27 22:15:34 Operation Nasal Vaccine. Please.https://t.co/OujfFxMgU6 @SciImmunology https://t.co/CtoZneSx9O
2022-10-27 21:49:26 Thanks to the swientists!https://t.co/YhPoxt6gaO @ScienceMagazine by @sciencecohen https://t.co/N48xJOHv12
2022-10-27 21:47:32 and this https://t.co/RnhEX54VOD
2022-10-27 19:11:59 @CathyLozupone @KristiKuhn @cu_medicine Agree!
2022-10-27 19:06:02 @BenIsraelow Delighted to do so, especially when it's so impressive and gives us much hope for a far better approach/defense
2022-10-27 18:30:09 Protective efficacy of the spike booster lasted for ~4 months, pan-sarbecovirus, using no adjuvants or replication-deficient or live attenuated virus (like FluMist), elicited broad neutralizing Abs.This is the variant-proof booster we need now to help prevent infections &
2022-10-27 18:16:56 Just published @ScienceMagazine A nasal vaccine booster (after primary vaccination) induces mucosal immunity —IgA, memory B and T cell—against the sarbecovirus family in the experimental modelhttps://t.co/j03xNjIXzhby @VirusesImmunity @tianyangmao and team @YaleIBIO @YaleMed https://t.co/M6LQUZWnlc
2022-10-27 17:44:25 RT @MassMedical: .@EricTopol said it would be a mistake to skip these shots. They still work, they just may not be much of an improvement o…
2022-10-27 17:39:01 Very hopeful signFrance is the 1st country in Europe to see the BQ.1.1 variant dominance (>
2022-10-26 21:05:00 The benefit of vaccination and boosters, along with prior Covid, against Omicron infections, in the California prison systemhttps://t.co/VSwHQIkwrD @NEJM https://t.co/3xg2Yn8DBm
2022-10-26 18:42:07 @Alexander_Tin @CNN @US_FDA @moderna_tx The number of participants in each of the 2 bivalent BA.5 booster independent studies is far greater than the ones Pfizer and Moderna have thus presented (zero) and are quite typical for assessment of neutralizing antibody response throughput the pandemic
2022-10-24 01:51:07 That Singapore's XBB variant wave was not severe, with relaxed mitigation, as @Fiona_M_Russell points out, is v encouraging https://t.co/tJuJ82OOBO —XBB's immune evasion could've ->
2022-10-24 01:21:15 @BagaiDr Many thanks Dr, Bagai!
2022-10-23 20:54:45 A booster is your best shot now. Why?https://t.co/G9Gnosk8E8
2022-10-23 18:04:32 It's not a good sign when 3 shots and a breakthrough (BA.1) infection (lower panel) doesn't elicit neutralizing antibodies to some of the new variants (BQ.1.1, XBB, BA.2.75.2) https://t.co/YS9rbTlSGZ
2022-10-23 16:21:46 RT @paula_span: The new bivalent COVID booster: Older folks, a highly vaccinated group, appear less interested in getting it than earlier s…
2022-10-23 16:17:42 @elderconsult I think the likely explanation is a high rate of prior infection, particularly with the Beta variant which seems to provide more cross-immunity than the others
2022-10-22 22:09:29 Thanks for the critique and feedback, @AstroKatie, @choo_ek and many others. A sense of equivalency was never intended. Preventing deaths, hospitalizations and #LongCovid towers over any liabilities.Here's a fixed version https://t.co/hrlYbI8rEI
2022-10-22 20:10:45 For the first year of vaccines, over 20 million lives saved around the world through December 2021 https://t.co/4GnPgEvg7W
2022-10-22 20:10:44 End of July 202291% reduction of deaths, all ages https://t.co/GIPkSo2daH
2022-10-22 20:10:42 Vaccines and boosters save lives. Across all ages.96% reduction of deaths for 2 boosters vs unvaccinatedEnd of May 2022@OurWorldInData https://t.co/UYkn5iszKT
2022-10-22 19:52:45 RT @cshperspectives: Sci comm irony when the first scientist quoted in a story has deleted their twitter account by the time the article ap…
2022-10-22 19:51:15 @JusDayDa @_TheAncientOne_ @MoritzGerstung Yes, that one is good, too. I had summarized it yesterdayhttps://t.co/fS78A4Vrwr
2022-10-22 19:32:01 @JusDayDa @MoritzGerstung Best I've seen is from @yunlong_cao and colleagueshttps://t.co/qWJ4AGtiur
2022-10-22 19:29:06 Avoiding #LongCovidhttps://t.co/VIVNew8bGWMy interview with @maggiemfox @Medscape, video w/ transcript https://t.co/FOpoBMAEOe
2022-10-22 16:59:36 A review of how #AI has been used during the pandemichttps://t.co/tvjS0ifKFE @PLOSDigiHealth "No clinical trials evaluating any applications impact on patient health" by @RANDCorporation @carlberdahl https://t.co/GeoWpysyyj
2022-10-22 15:31:45 The BQ.1.x wave projection for the US, and calculations for many other countries based on growth advantage vs BA.5, by @MoritzGerstung https://t.co/4TozbJWNLa https://t.co/wtuI1qLi4r
2022-10-22 14:15:56 Their XBB wave was projected to exceed BA.5.Strong NPI mitigation practices and very high vaccine/booster uptake (a top 10 country) likely contributed https://t.co/93Vd3T3Qg2
2022-10-22 14:05:17 This is very good news.The XBB variant wave in Singapore is in descenthttps://t.co/mZS5FePzrNXBB and BQ.1.1 are 2 of the most immune evasive variants and Singapore was the first country to experience a wave induced by one of them, now letting up https://t.co/DbkSC4OPN7
2022-10-22 01:27:48 @BMcranty @AstroKatie @Sarcasmorator I don't consider major reduction of deaths, hospitalizations, and #LongCovid as "meh"
2022-10-21 22:51:43 91% reduction of Covid deaths for age 50+ with 2 boosters, August 2022, vs unvaccinated BA.5 wave https://t.co/HGyjNwCm0v https://t.co/VI7LzxaLtM
2022-10-21 22:11:19 @AstroKatie I'm with you. Trying to provide as much balance as possible
2022-10-21 22:08:33 Yesterday's @CDCMMWR report that shows slippage of protection vs hospitalization after 4 months, age 18+, during BA.5 wavehttps://t.co/DRB7tiyffU https://t.co/1bTzbZvhAv
2022-10-21 22:05:10 @Sara43347888 The answer is NO. The @sfchronicle headline is terrible and worse than that is to have it behind a paywall. Unacceptable.
2022-10-21 22:01:41 For ages 18-49, the 72% reduction of Covid hospitalizations with ≥ boosterhttps://t.co/M2Bu9rj1Ve https://t.co/DX8wcxAzzt
2022-10-21 21:48:59 Since Omicron in late 2021, mRNA booster protection vs infections &
2022-10-21 20:53:57 @JohnRossMD That's one of several refutes See @K_G_Andersen https://t.co/HcVEo29XaAAnd @Friedemann1https://t.co/VJCmgWR1Vj
2022-10-21 20:45:55 RT @JohnRossMD: In case you missed it, UK COVID minimizer Francois Balloux has deleted his account after amplifying a spectacularly wrong p…
2022-10-21 18:27:42 RT @JReinerMD: Pfizer projects that it will make $32 billion from its COVID vaccine in 2022 and $22 billion from Paxlovid. Their plan to ch…
2022-10-21 17:41:28 The BQ variants and the UShttps://t.co/KEeCny0P9A by @ErinMPrater @FortuneMagazine
2022-10-21 16:36:27 RT @K_G_Andersen: BQ.1(.1)* picking up steam, but still too low to be making a major difference in cases/hospitalizations - follow this tre…
2022-10-21 15:59:15 That's right—Covid boosters aren't for everyone.But for WSJ to print this seriously flawed claim about cardiac deaths in men age 18-39 is inappropriate, to say the least https://t.co/KCox0mhlHG https://t.co/NixQ2Uki1R
2022-10-21 15:02:26 New lab assessment of these variantsBQ.1.1 has the most immune evasion and fusogenicityhttps://t.co/5FQn5FxOZ1 https://t.co/PmZPkQHB4n
2022-10-21 14:50:01 What are the #SARSCoV2 variants accounting for US cases?New CDC genomic surveillance updateOn the rise: Predominantly BQ.1 and BQ.1.1 (~17%), also BF.7 (7%), BA.2.75.2On the decline: BA.5, BA.4.6https://t.co/jjl2AnwOWX https://t.co/r7i6cYnjSe
2022-10-21 14:37:20 RT @mhornig: Not convinced efforts to avoid #SARSCoV2 infx are worth it? Think #LongCOVID and potential for #MECFS are fantasy? Please list…
2022-10-21 14:20:48 Myalgic encephalomyelitis was first recorded in 1934 in Los Angeles after an outbreak of atypical polio. It has taken nearly a century and #LongCovid to "get needed attention"https://t.co/ryyI15mfnf @NanetteAsimov #mecfs https://t.co/xOYiOk9R2A
2022-10-21 02:54:11 Keep an eye on New York, leading the country with % cases BQ.1.1, bellwether for the next wave https://t.co/vw77IAyHJj (update, first picked up by @JPWeiland) https://t.co/MPJSVvzqEY
2022-10-21 01:50:07 The inversion (next wave) is likely starting by the rise in hospitalizations. Great time for CDC to stop daily tracking https://t.co/RXymG9t41x
2022-10-20 23:56:25 On the imprinting issue, in the Discussion"antibody responses to some Omicron S[spike]-specific epitopes were hindered by prior antigenic exposure" https://t.co/w9oiWH8s5A
2022-10-20 22:39:04 Is the science information credible? For the competent outsider:https://t.co/cuyEKL762s@danrpimentel @ScienceMagazine https://t.co/z8WsB1TOjF
2022-10-20 20:02:03 The mechanism by which time-restricted eating limits obesity (in mice)https://t.co/gENt2Muxtq@DamienLagarde @kazaklab @ScienceMagazine @ScienceVisualsre:https://t.co/DN3oCsON5y@JoeBass91471540 and colleagues https://t.co/iVqHsgvAy8
2022-10-20 18:57:29 Vaccination alone did not induce neutralizing activity in the nasal mucosa, but that was achieved via breakthrough infections."These observations... .motivate the development and evaluation of a next generation of vaccines administered intranasally." https://t.co/XIaSiKDJ7R
2022-10-20 18:36:12 "We identified an ultrapotent pan-variant neutralizing antibody, that is a strong candidate for clinical development."https://t.co/jlo7fjwCr5@ScienceMagazine @veeslerlab https://t.co/bwBA8q2zfQ
2022-10-20 18:30:15 A feature @ScienceMagazine on what to do about lab virus work https://t.co/aZhzc3k7X8 by @jocelynkaiser https://t.co/Ypyp24G90K
2022-10-20 17:17:31 Also to note that 60%+ max is not the 80%+ protection vs hospitalization that was consistently seen prior to BA.5, (90%+ for Delta and prior strains) and that finding replicates 2 other studies.Underscores the importance and need for a variant-proof, pan-sarbecovirus vaccine
2022-10-20 17:07:07 Why a booster is important to maintain protection from hospitalization: waning immunityNew @CDCMMWR shows the protection vs BA.5 drops down to 37% (2 shots) and 29% (3 shots) after 4 monthshttps://t.co/DRB7tiyffUData are for all ages 18+ https://t.co/Pa0PtdlWIY
2022-10-20 15:30:35 In a prospective cohort of critically ill adults, sequencing the blood (metagenomics) identified the pathogen 99% and predicted sepsis in 74%https://t.co/tQTgyQHSjY@NatureMicrobiol @UCSF @klkalantar and colleagues https://t.co/wx4u4HpqD5
2022-10-20 13:33:04 "Middle-aged people accounted for the biggest losses in life expectancy"https://t.co/czRQeP2WkHMore at "In America and eastern Europe, covid-19 got worse in 2021" https://t.co/SxZup76Cic
2022-10-20 12:47:01 RT @bmj_latest: “This virus is so amenable to taking it down . . . But we’re just not acting like we can do this. And we can.” @EricTopol…
2022-10-20 01:56:23 RT @EricTopol: There's a lot of total BS out there about myocarditis in kids and adolescents. To state facts:1. CDC does NOT decide about…
2022-10-19 22:20:40 For children 5-11 years in males, 2nd dosethe rate is 2.5 per million https://t.co/kXEH3wMsZl
2022-10-19 22:14:25 There's a lot of total BS out there about myocarditis in kids and adolescents. To state facts:1. CDC does NOT decide about Covid vaccines in schools 2. There are no kids dying of myocarditis from the vaccines3. It is very rare, mild 4. The anti-vaxx world has gone beserk
2022-10-19 21:56:45 The BA.4.6 variant accounts for ~12% of US Covid cases (pattern of growth below, left). Its level of immune escape was characterized @NEJM today: 2-3 fold less neutralizing antibodies than BA.5 (below, right)https://t.co/WdRlUvagsW @BarouchLab https://t.co/HCJYiczVfX
2022-10-19 21:38:19 A timely, outstanding @NEJM review on myocarditis today https://t.co/WAT7pvAMZX by @Cristinabasso64 https://t.co/kx9NytqNro
2022-10-19 21:06:24 Randomized, placebo-controlled trial of the 2-dose @moderna_tx vaccine in children 6 months to 5 years, during Omicron. Safe in ~4,800 kids
2022-10-19 21:00:25 New @NEJM"Our study indicates that [Pfizer] vaccine-induced myocarditis in adolescents appears to be a rare adverse event [<
2022-10-19 19:10:16 "Alexa, what's a mechanical neural network?"https://t.co/3d8yQNsBO1 @SciRobotics #AI https://t.co/X5TbigpMCa
2022-10-19 18:00:25 4. No increased risk of miscarriage or other pregnancy complications from vaccination or booster https://t.co/mVFxD3aE8e
2022-10-19 18:00:23 3. Newborn/infant (0-5 months) avoidance of hospitalization by mother's vaccination https://t.co/T2Wut9L6kK
2022-10-19 18:00:21 2. Vaccination protected vs hospitalization vs Delta and Omicron infections with booster (same with ED or urgent care visits)But 57% of expectant mothers have not been vaccinated or had a booster https://t.co/e9BEJwfVse
2022-10-18 23:34:04 RT @morgfair: I got my booster AND flu shot 3 weeks ago. Please consider making time to get these vaccines in order to protect yourself and…
2022-10-18 23:32:35 And it looks like the 25,000 threshold was not crossed after all, erroneous data @medriva https://t.co/tYv0wdLUup
2022-10-18 23:27:30 @JPWeiland Very strange, since they were in synch, ??
2022-10-18 23:19:33 Sadly, an inversion is in the works in the weeks ahead.And that will be amplified by lack of US booster protection, especially in age 50+, but there was 72% reduction of hospitalizations during BA.5 for age 18-49 https://t.co/M2Bu9rj1Ve https://t.co/2mB1G9juGg
2022-10-18 23:09:33 Today is the first time US Covid hospitalizations went below 25,000 in 5 months https://t.co/Y2TdaIXScs
2022-10-18 23:02:07 Denmark's BA.5 wave. Prior Omicron infection plus booster had high protection against reinfection (93%) and hospitalization (96%). The risk of BA.5 hospitalizations was higher than the prior BA.2 wavehttps://t.co/0G1oRpViRd @TheLancetInfDis @C_HHansen @SSI_dk https://t.co/1hI1eg0PlH
2022-10-18 21:04:49 Reinfections, from @sporeMOH https://t.co/YiAqPtn4LV https://t.co/yvL2JVmiTq
2022-10-18 19:58:11 We've been thinking that the Omicron variant evolved from an immunocompromised individual with accelerated in vivo mutations. A new report @PNASNews raises the potential that it emanated from mice ->
2022-10-18 19:41:38 RT @florian_krammer: 1) Boston University researches have made a SARS-CoV-2 virus that has the spike of Omicron BA.1 and the remaining geno…
2022-10-18 18:46:11 The human asks: "Is there a bacteria on the slide?"The #AI responds: "Yes, indeed, and I've identified it for you"https://t.co/6d14dbMWAn @naturemethods developed by @KevinJohnCutler, a @UW physics grad student, with explanatory thread below https://t.co/axnXgss6qr
2022-10-18 18:01:02 Each day in the United States our immunity wall (vs severe Covid) develops more cracks in itWhy?Far more people have their vaccine or infection-induced immunity waned than are getting a booster
2022-10-18 17:24:41 ImmunosenescenceAdvanced age and reduced Covid mRNA vaccine induction of neutralizing antibodies and T-cell responseAnother reason why boosters, by preempting waning immunity, is so important in older age groupshttps://t.co/SF7YhiRIRs @NatureAging https://t.co/76cQS4hq5K https://t.co/U3gZaJgbax
2022-10-18 16:00:50 The XBB variant wave in Singapore will soon be their 2nd worst for the pandemic. The reinfection rate prior to the wave was 5% and now up to 17%, which tells us about the immune escape properties of this variant (akin to BQ.1.1, very high level of immune evasion) https://t.co/IMoMuymp75
2022-10-18 15:26:11 For essential workers, a recent (<
2022-10-18 15:15:22 The US purchased 171 million bivalent BA.5 booster shots
2022-10-18 14:32:36 Inflammation and dysfunction of the lining of blood vessels—the endothelium—is the basis for many of the cardiovascular complications of Covid. A new, solid review here https://t.co/1GiS8XXzT7 https://t.co/CSBS7xjXCR
2022-10-18 03:49:18 RT @dnewheiser: In case it wasn't clear, the widespread prevalence of long COVID is a VERY BAD THING.@EricTopol explains that COVID is as…
2022-10-17 23:23:08 "The results reveal inequalities in molecular risk factors for chronic diseases often decades before diagnoses"Linking socioeconomic status (SES) and mRNA signatures of disease in >
2022-10-17 21:45:07 The choice of blood thinner for patients w/ atrial fibrillation &
2022-10-17 21:33:41 Why reducing the cost of insulin is critical"A total of 16.5% (95% CI, 13.8% to 19.6%) of insulin users rationed insulin ["to save money"] in the past year, or 1.3 million adults with diabetes nationwide."https://t.co/l6Vnd1WYD7@AnnalsofIM https://t.co/d7y1Borr49
2022-10-17 21:20:49 "Countries with a higher share of vaccinated individuals suffered the least life expectancy deficit."and to note bounce back of USA for age 80+ in 2021https://t.co/EM2Fq0hciJSummary of the paper@jschoeley @jm_aburto @ridhikash07 @OxfordDemSci https://t.co/gHSvgiTj90
2022-10-17 18:21:33 How to protect vs the XBB variant wave in Singapore?With the new and significant wave, cases are up, along with hospitalizations. The 79% population booster rate (double the US) is helping to avoid severe outcomes https://t.co/mZS5FePzrN @sporeMOH https://t.co/JVmgqD15OW
2022-10-17 18:06:14 Biomarker hunt for correlation with #LongCovid risk 7 months out from 108 people with mild to moderate Covid comes up with candidates such as Rig-1 and multiple cytokineshttps://t.co/lESwHXAmWv@eLife https://t.co/5q4qRgJxxU
2022-10-17 16:09:10 In contrast to most other countries, the life expectancy decline in the US occurred across all ages 20+ "In the United States, the pandemic has accentuated the pre-existing mid-life mortality crisis. This is clear from the strong contribution of increasing mortality <
2022-10-17 15:55:44 Making human salivary gland organoids to determine #SARSCoV2 infectivity https://t.co/GkOjqWt2c9 @NatureCellBio "SARS-CoV-2 derived from saliva in asymptomatic individuals may participate in the spread of the virus" https://t.co/cWRA6BgBi1
2022-10-17 15:11:30 Life expectancy changes during the Covid pandemic among 29 countries: the US among the most pronounced reduction. Several countries had bounce back improvement in 2021 (black arrows below). Vaccination uptake was correlated w/ less deficithttps://t.co/DIxN3ZrvsK @NatureHumBehav https://t.co/GE2VJMjP84
2022-10-17 14:25:01 Good review of the treatments that have been validated for Covid https://t.co/aavLANCV4A by @nymurakami @DavidLeaf9 and colleagues @BWHKidney @NatRevNeph https://t.co/WRqSbh81WP
2022-10-16 22:47:21 RT @JPWeiland: Something interesting is happening in New York. Cases have been flat over the past month, however hospitalizations are jump…
2022-10-16 18:25:06 The @sporeMOHreport on the XBB variant wave https://t.co/LwzJzRh2Hk…—Expects peak of 15,000 cases/d (>
2022-10-16 15:40:11 RT @florian_krammer: Ours is moving. Phase II in Mexico, Phase I in the US. But funding in the US for these vaccines is hard to find.
2022-10-08 15:32:28 Our digital times :-)by @speedbumpcomic https://t.co/LzEjDTehAV
2022-10-08 14:50:36 The start of Singapore's XBB variant waveNotable how this variant left BA.2.3.20 in the dust, a variant with substantial growth advantage over BA.5
2022-10-08 01:55:55 Keep this summary data--preventing deaths--in mindhttps://t.co/Vc87IkH9WS
2022-10-08 01:52:24 2 key data points from the segment https://t.co/yjL0j9YNQC
2022-10-08 01:34:54 A data-driven segment on vaccines and boosters worth watching.Thanks @chrislhayes for staying on this as we face a new wave in the weeks ahead with an exceptionally low (34%) booster rate (half that of all high income countries) https://t.co/N2K3QCptrz
2022-10-07 22:15:48 @DanRather To support you point, DanLives saved in 2021 by Covid vaccines and boostershttps://t.co/ICyk0xZBiG
2022-10-07 18:50:43 Why do some people develop blood pressure dysregulation after severe Covid?https://t.co/yYGSMBTWQc@ScienceAdvances by @UChicagoPME @UChicago @srouhani1 and collaborators https://t.co/G5X7hIbHHC
2022-10-07 18:07:31 For more on today's UK report, an informative thread https://t.co/Dnz16oZ8ko
2022-10-07 17:54:04 New weekly US genomic surveillance https://t.co/jjl2AnwOWXBA.5 continues to fade as BA.2.75x creeps up, BF.7 (BA.5.2.1.X) &
2022-10-07 17:31:38 In a large US cohort of ~200,000 people who had Covid, vaccination reduced the risk of #LongCovid by 30-40% and this protection persisted through breakthrough infectionshttps://t.co/UqFViYOWdm
2022-10-07 17:02:35 A new profile on @Tuliodna &
2022-10-07 15:03:14 RT @EricTopol: @ArianaSeigel Since Omicron emerged, the vaccine/booster protection vs infection and spread has diminished and is less durab…
2022-10-07 14:15:21 RT @hholdenthorp: The medical establishment, especially @AAMCtoday and @AmerMedicalAssn, really needs to own the damage they are doing by n…
2022-10-07 14:10:56 The US booster rate (34%) vs peer, high income countries https://t.co/DVvWNke276
2022-10-07 13:51:21 @cindymclennan @NatureMedicine No, it's the BA.5 bivalent, but we don't have such data on that yet. This Beta variant bivalent was never made at scale
2022-10-07 13:45:42 @JELesq Yes. Read Ryan Hisner's threadhttps://t.co/hSwCNBpMHc
2022-10-07 13:39:46 New and encouraging @NatureMedicine on bivalent Beta booster"These results indicate that bivalent booster vaccines can induce potent, durable and broad antibody responses against multiple variants, providing a new tool in response to emerging variants"https://t.co/H5Q98bXoHa https://t.co/reK5Jx99sx
2022-10-07 12:51:24 The US booster rate is less than half of all its peer countries, leaving Americans vulnerable now and as the next wave hits in the weeks ahead. By @ddiamond @VPMaryBeth @majohnso https://t.co/f4OYPlfvFd
2022-10-07 03:07:23 New on MolnupiravirA randomized trial of ~26,000 patients with Covid, mean age 57 with 2 days of symptoms, showed no difference in hospitalizations or deaths, the primary endpoint, compared with usual carehttps://t.co/6ai5AawdLn https://t.co/HIF845BRLx
2022-10-06 23:01:43 In my clinic today, after routine 6-lead ECG and during smartphone echo, a faster heart rate was noted. Repeat 6-lead ECG showed atrial flutter. All part of the extended physical exam with sensors
2022-10-06 21:06:12 Good summary today on this innovation and why time to diagnosis is so critical https://t.co/F5SxIIcsnQ @Medscape
2022-10-06 20:21:23 Masks help. So do vaccines and boosters.Japan has the lowest Covid death rate of any large country in the world, per capita https://t.co/adUZVdUcu8
2022-10-06 17:38:48 @TigerlillySusan BQ.1.1 is there but not at levels that would be driving a case wave (yet)
2022-10-06 17:32:23 Unlike Singapore, where the XBB variant wave has begun https://t.co/cT9YQbHiBn
2022-10-06 17:32:22 Here we go, before the new variants kick in https://t.co/FwMmKSqE73
2022-10-06 17:09:02 The #AI can "see" kidney disease from your retina and anemia from your electrocardiogramhttps://t.co/l8GkL5vyaC
2022-10-06 15:13:46 "During the pandemic, the practice [in Japan] became pervasive, though the gov't has never enforced a mask mandate... A recent survey showed that half of Japanese would like to keep wearing masks as much as possible, regardless of medical advice or rules."https://t.co/Avfztzfd0R
2022-10-06 14:44:48 https://t.co/OsGmJVDZzW
2022-10-06 14:32:12 It's "Data Liberation Day" in the United StatesPatients can now access all *their* health records A real liberation would mean having, controlling, owning all *our* medical datahttps://t.co/zATgTyrhhC @statnews @caseymross
2022-10-06 14:25:27 @TWenseleers Start of the first XBB wave? https://t.co/J4VpmygBdB
2022-10-06 01:13:22 RT @TWenseleers: @EricTopol @Tuliodna This is the growth rate advantages I am getting of these different emerging lineages based on a fit t…
2022-10-06 01:03:25 The relationship between climate and CovidA comprehensive and very thoughtful assessmenthttps://t.co/Rb90ME8Rky @TheLancetPlanet @ccadapt @B_vanBavel @carolzavaleta and colleagues https://t.co/jwg3ZOrNBB
2022-10-05 23:37:54 @Tuliodna Hope you are right, TulioBut some of these look pretty menacing (especially BQ.1.1 and XBB right now)
2022-10-05 23:18:33 There's also this new study on T-cell immunity induced by prior infections or vaccination or both (hybrid)https://t.co/VHneulgImm@NatureComms https://t.co/KoNPpMPjH2
2022-10-05 23:18:32 There has not been adequate regard for the level of immunity acquired from Covid infection, albeit with its attendant risk and unpredictable #LongCovid sequelae.I reviewed many of the earlier studies in this threadhttps://t.co/dWMGRpKKVa
2022-10-05 23:18:31 A systematic review for protection vs Omicron hospitalization or severe disease out to 6 monthsHybrid immunity + 3 shots 95%Hybrid immunity + 2 shots 96%Prior Covid alone 80%Vaccination (2 shots) alone 65%https://t.co/z0JxOhaaZM @nikbobrovitz @lsubissi https://t.co/JS2dSTpEj3
2022-10-05 21:20:50 Prior Omicron infections protected against BA.5 (~80% effectiveness) whereas prior Covid, non-Omicron protection was markedly lower (~30%). Likely related both to immunity waning and cross-immunity within Omicron lineageshttps://t.co/kEtABqGH97 @NEJM https://t.co/V9wjEcGczS
2022-10-05 18:46:25 @AmyGlaw_1 @RajlabN @CorneliusRoemer Thank you. Yes, definitely
2022-10-05 18:33:27 RT @rkhamsi: Holy smokes! This is maybe the most important paper I’ve read in 2022…We know that this #COVID virus is good at hiding from…
2022-10-05 18:26:58 Knock 'em all out.Discovery by @EmoryVaccineCtr of a broadly neutralizing antibody (bnAb) vs all #SARSCoV2 variants through BA.5. Could be used alone or in combo w/ other bnAbs to make a variant-proof vaccinehttps://t.co/r3YDB1FOB0 @ScienceAdvances @SanjeevKumar_01 https://t.co/nUWf21gUuX
2022-10-05 16:42:27 "Alpha Tensor typically discovers thousands of algorithms for each size of matrix""Algorithms that multiply large matrices 10-20% faster than those commonly used on that piece of hardware"from the Cliff Notes versionhttps://t.co/8VPDQ2ySAT https://t.co/ZhWI3enwhY
2022-10-01 01:18:36 RT @marypcbuk: I valye twitter for precisely this flattening
2022-10-01 00:36:14 @dan_psyd Agree https://t.co/XrEHsI1uC5
2022-09-30 23:33:25 On the two-edged sword of @Twitter, by @richardhorton1 @TheLancet https://t.co/JXjjw150JZThanks for the mention with @chrischirp https://t.co/7GR1Kf1Xoh
2022-09-30 23:14:54 Already high before the pandemic, the alarming current rate (63%) and increase in physician burnout "We cared about quality of patients' experience, building relationships with them"https://t.co/MJJfpv5kHk @oliverwhang21 w/ @JBryanSexton1 @JBryanSexton1 @MayoProceedings https://t.co/YhcozuPjQh
2022-09-30 19:05:57 RT @CatchTheBaby: @RajlabN Thanks. This is very helpful.BQ.1.1 is concerning since it is resistant to both Evusheld and Bebtelovimab. http…
2022-09-30 18:59:36 Broadly neutralizing antibodies (bnAbs) are the template for variant-proof, pansarbecovirus vaccines. A new review shows the extensive discovery work has been to find bnAbs, and these are just vs the spike protein!https://t.co/dN8XsURly3@NatRevImmunol https://t.co/3DvfXiwOHN
2022-09-30 17:54:15 Current data (28 September), for those past 6 monthsAge 65+, <
2022-09-30 17:08:44 Each day in the US we have far more people whose immunity has waned, >
2022-09-30 15:58:59 RT @Tuliodna: Early reflections of the historical event @Illumina genomics forum. In this short thread, I highlight that it is not the tech…
2022-09-30 15:16:20 New US genomic surveillanceAs the BA.5 variant proportion of cases descends, the rise of BA.4.6 (13%), BF.7 (aka BA.5.2.1.7
2022-09-30 14:50:51 We've seen this movie before@OurWorldInData https://t.co/rIIR21VdsA
2022-09-30 14:39:24 No, people don't die of "old age."https://t.co/KmASnvxZNs by @MarkLandler https://t.co/viETh0rE1Hby @miho_inada https://t.co/Rm7ll7jXW6
2022-09-30 01:19:05 For #AI to be an integral part of medical practice, compelling data from randomized and prospective trials are needed. A new systematic review of all 41 RCTs shows the weak status of what has been done to datehttps://t.co/Gj8ToPdGJZ @PlanaDeborah @dlshung @BenjaminKannMD https://t.co/WdJ7iZAy4z
2022-09-30 00:42:06 RT @TIME: "Hannah Davis (@ahandvanish)’s advocacy has been a light in the darkness for many people whose Long COVID struggles have been dou…
2022-09-29 22:00:38 "We show how this [science-guided] battle got lost on Facebook very early during the COVID-19 pandemic and why the mainstream majority, including many parenting communities, had already moved closer to more extreme communities by the time vaccines arrived"https://t.co/IMUyqA80Xo https://t.co/qFrA74XBNs
2022-09-29 21:31:02 And here's a short video what we're doing for a universal, variant-proof Covid vaccine, via joint efforts of immunology and structural biology, with @DennisRBurton and Ian Wilson, @WardLab1https://t.co/yjYPkSBERa
2022-09-29 19:20:04 How to accurately identify an uncommon and lethal disease (IPF) 1 to 4 years sooner than in general medical practice?Train #AI with data from 3 million people, >
2022-09-29 18:56:34 New @USGAO @theNAMedicine report on #AI in healthcare https://t.co/ZHui8ACW92 addressing the challenges, glad to have participated @theNASEM https://t.co/T0mqQ6i0LW https://t.co/MhIq0hhNnm
2022-09-29 18:40:43 My @scrippsresearch colleagues just published @nchembio a new oral drug vs Covid that blocks ACE2 binding to the spike protein, inhibiting viral entry and infections in the experimental modelhttps://t.co/lronrARbxU https://t.co/a18sJ64O1a
2022-09-29 17:49:30 @ImmunomePro @waynekoff1 @TedSchenkelberg So glad to be a part of this new and exciting initiative with planning over the past few days, bringing together leading immunologists and computer/data scientists from all over the world
2022-09-29 14:23:11 False positives and unnecessary biopsies frequently arise from mammography screening for breast cancer. A new study using #AI of MRI scans shows the potential for much improvement https://t.co/uCZy32IBlp @ScienceTM @JanWitowski @kjgeras@nyuniversity @nyugrossman and colleagues https://t.co/CsTpJA7EI7
2022-09-29 01:17:37 He basically summarized we've made solid progress with genomics research, such as with the @AllofUsResearch program, but slow to move to the clinical realmAgree. We'll get there eventually....... https://t.co/NmbW8oHwNc
2022-09-29 00:42:20 Good to hear @BarackObama’s candid appraisal of where we stand with precision medicine #IGF https://t.co/cfyBBeFy7i
2022-09-28 19:35:51 RT @Alex_Aravanis: Looking forward to hearing from @francesarnold, @EricTopol, @amyleecp3, @j_echevarria, @clopezcorrea, and @WohlgemuthJay…
2022-09-28 16:20:29 The Lasker-DeBakey Medical Research Award today for discovery of circulating cell-free fetal DNA, the foundation for prenatal screening. Congratulations to Dennis Lohttps://t.co/N8tKiMKoSQ @NEJM @LaskerFDN https://t.co/g2RXi6W3iz
2022-09-28 15:48:15 What may be the sequelae of the new variants https://t.co/f37WFDZaUn by @GretchenVogel1 @ScienceMagazine (hint: the pandemic isn't over)And my simplified version of @dfocosi'soutstanding convergence map highlighting the 2 variants discussed in this piece https://t.co/GwfrweY5iO
2022-09-28 14:29:15 A small pilot study of plasma proteomics in health care workers with mild Covid or controls suggests potential for predicting #LongCovid https://t.co/Nygcmq4VN8 @eBioMedicine @uclnews @gabycaptur @DrWendy_Heywood https://t.co/y7anc6T31W
2022-09-28 02:37:15 @Tuliodna @christian_happi @fdesouza @illumina Welcome, Tulio and team, to Capetown of the US, without Table Mountain
2022-09-28 00:12:24 Has the β-amyloid hypothesis for Alzheimer's (AD) finally been proven? Results of a Phase 3, placebo-controlled trial of a monoclonal Ab in 1,800 participants with early stage AD raises the possibility (need to see all the data)https://t.co/npXgPzNAht https://t.co/OYlvevWCNv
2022-09-27 22:53:24 The BA.4.6 variant now accounts for >
2022-09-27 22:16:49 How long is Covid infectious and what's the best way to track it that correlates with culture positivity?"Most adults have replication-competent #SARSCoV2 for 10-14 after symptom onset, and N antigen testing is a strong predictor of viral infectiousness"https://t.co/we0hTuzKjk https://t.co/uf1AVGd5ZT
2022-09-27 18:26:48 @dfocosi @TRyanGregory @florian_krammer @Tuliodna @CorneliusRoemer @PeacockFlu @DrEricDing @kakape @SolidEvidence @ewencallaway @RobertoBurioni @mlipsitch @JeremyKonyndyk Info overload!My dumbed-down version https://t.co/Vfq1xPrKHw
2022-09-27 18:03:50 Current CDC recommendations>
2022-09-27 17:11:56 A very interesting report that adds to the possible underpinnings of #LongCovid. Reactivation of viruses such as EBV has been raised, along w/ persistent remnants/reservoir of #SARSCoV2, and autoimmunity. But imprinting from a common cold coronavirus is unlike these mechanisms
2022-09-27 15:46:49 The Cliff Notes version of this important study@NatureMedicine https://t.co/vwzkq448LU https://t.co/tlYdhUsepI
2022-09-27 14:53:21 Good summary @PopSci integrates findings from a 3rd report https://t.co/R9AwAdv7cZ by @LPBaisas
2022-09-27 14:42:37 The persistent excess of arterial and venous blood clots after Covid at 1 year compared with controlshttps://t.co/phpGVQgCOh @CircAHA by @jonathanasterne and colleagues https://t.co/Q0ONqbnHr3
2022-09-27 13:56:37 @DFisman @kasza_leslie @VirusesImmunity Thanks David! Prime + nasal boostThe link for those interestedhttps://t.co/OujfFxvdS6 @SciImmunology
2022-09-27 13:33:48 New @CellCellPress Why getting a booster too soon after Covid is not a good idea: suboptimal B-cell responsehttps://t.co/ZMFiSFxa0R@NIAIDNews https://t.co/GGMfM2OATG
2022-09-27 01:34:49 These results are derived from ~450,000 people prospectively followed for 12.5 yearsChallenging medical dogma, arrhythmias were reduced by coffee (caffeinated, not decaffeinated), as was heart failure and strokeUsual caveats of self-reporting https://t.co/AUpZKemkW0
2022-09-27 00:23:53 Coffee lovers will love this new report
2022-09-25 15:57:46 @luckytran Over 200,000 Americans died from Covid in 2022 and still now >
2022-09-25 15:34:16 A good graphic on imprinting. We don't yet know how well the bivalent BA.5 will do, but boosters are our best shot for maintaining high level protection vs severe Covidhttps://t.co/aqOp2TpAUDSummary of what's known about boosters
2022-09-25 15:19:54 Sneak preview of what's to come from @JosetteSchoenma BA.2.75.2 and BQ.1.1 in 3 countrieshttps://t.co/qqPnt9vYqO
2022-09-24 21:55:55 @AlbertBourla @loscharlos "Back in mid-August"A reinfection in such a short time bespeaks the big unmet need to block infections and spread, which we're not going to get better at with shots at this point
2022-09-24 17:53:46 Nothing to worry about out there
2022-09-24 16:14:28 The 4-D ultrasound image of the fetus (age 32-36 weeks) after the mother eats kale :-)https://t.co/FIkqxdi30C https://t.co/aBe91sTWUS
2022-09-24 16:01:35 Our metabolites indicate risk of more than 20 common diseases beyond traditional clinical risk factorsNew @NatureMedicine report from ~120,000 participants, >
2022-09-24 15:51:26 Retina images are emerging as a window to blood pressure and glucose control, kidney and hepatobiliary diseases, risk of heart disease, and Alzheimer's. Could they be a biomarker for #LongCovid?https://t.co/AFUypPKoZt https://t.co/DXhxQREHbD
2022-09-23 22:32:29 RT @captainslim: I’ve been enrolled in this study almost since it started. I’m fascinated by the idea of using passively collected data fro…
2022-09-23 20:31:25 Pandemic virus sequencing has provided the notable edge of seeing variants before they go exponential, characterizing them, determining in advance whether and which treatments (mAbs), vaccines will be effective More here: https://t.co/xr8J0OtwED by @PhilFebboMD_CMO
2022-09-23 20:22:53 And my prior post on 2 with immunoprofiling (BA.2.75.2 and BQ.1.1)https://t.co/p6F7JAUxFc
2022-09-23 20:21:00 New info on the major variants on the radar screen, by @yunlong_cao https://t.co/Qg4Nxc0W82
2022-09-23 19:59:30 These 2 large studies are consistent and concerning.Reminder: it took ~15 years after the 1918-9 pandemic to pick up the increased risk of Parkinson's disease among survivors.
2022-09-23 19:40:25 The immune system response &
2022-09-23 19:01:54 Work @ScienceMagazine w/ @ScienceVisuals Report by Yang Cao @zhenqi_zhou @MarcusSeldin @DOM_UCLA @KeckMedUSC @dgsomucla Perspective by @josephahill https://t.co/ts08EMj8BL
2022-09-23 18:51:57 We know about the heart-brain and brain-gut interactive axis. Now there's the liver-heart:A clotting factor (FXI) made in the liver protects the heart (unexpectedly) from failurehttps://t.co/vG2cFlo0Jghttps://t.co/4BqeHEiMyu https://t.co/ZizV6OvrbO
2022-09-23 15:57:34 Note. Good time to be sure you get a booster if you're ≥4 months out https://t.co/bi4HV1cdHj @NicolaKSDavis @guardianscience https://t.co/Iy3EfcY5nXhttps://t.co/KRqlB6UNMx @ONS https://t.co/ZC3UCHbDCo
2022-09-23 15:36:24 Using epigenomics (methylation markers) a person's biologic age can be determined fairly accuratelyNow digitizing #brain age is getting attention via imaging #AIOur new @Lancet Digital Medicine essay@DavidJonesBrain @NaipMayo https://t.co/bA6ypagsJC https://t.co/VRAx1Bk8r2
2022-09-23 15:12:15 Two new independent reports, one Norway nationwide, and the other US-based, indicate increased risk of Type 1 (autoimmune) diabetes from Covid in children and teenshttps://t.co/8zTYGLmblk@EASDnews https://t.co/q4t1DfcYk9 @JAMANetworkOpen https://t.co/fn1Wqnf2Th
2022-09-23 14:39:15 For opera, "It ain't over till the fat lady sings"For the pandemic, It ain't over (contained, under control, ahead of it) till we get better vaccines that block infections and spread (e.g. nasal) and are variant-proof, pan-sarbecovirus
2022-09-23 14:11:17 And @EllingUlrich has an insightful thread about both the convergent and non-convergent mutations for the new variants https://t.co/M6yWQqEren https://t.co/WgB5SZXZEv
2022-09-23 14:11:16 Here @SolidEvidence has mapped out their evolutionary path with a convergence of several mutations https://t.co/XEfxyTn0n0
2022-09-23 14:11:14 New US #SARSCoV2 genomic surveillance dataThe proportion of BA.5 cases is declining, as new variants are out-competing, some of which have already been shown to have more immune escape such as BA.2.75.2 and BQ.1.1https://t.co/jjl2AnOYb5 https://t.co/FUSgl3CAR0
2022-09-23 13:54:27 RT @NatureMedicine: In our latest Review: Multimodal #AI models could unlock many exciting applications in health and medicine
2022-09-23 01:41:31 The global Covid death toll would be more than double by now without vaccines (about 50 million people died in the 1918 influenza pandemic)https://t.co/RGe96GeJ5s
2022-09-23 01:31:34 Although we have no validated treatments yet for #LongCovid, a new @bmj_latest paper provides practical support and guidance for both patients and clinicians https://t.co/eBKGloKDEI by @trishgreenhalgh @sivanmanoj @bcdelaney1 @REvans_Breathe @ruairidhm https://t.co/1DGWMqjOxI
2022-09-22 23:54:39 Why wrist sensor surveillance should be part of pandemic monitoring https://t.co/2cTRFyybzg @LancetDigitalH by @jmradin @GiorgioQuer @JayPandit @ScrippsRTI @careevolution @SteveSteinhubl @BacaMotes @ERamosPhD @GadaletaMatteo @scrippsresearch https://t.co/0GyqYpqBif
2022-09-22 21:09:42 Think outside the spike (again)#SARSCoV2's ORF7a protein inhibits antigen presentation CD8+ T cells, may contribute to immune evasion https://t.co/toygmNWQxE@PNASNews @PaulBieniasz @RockefellerUniv https://t.co/ACjP7UYZHK
2022-09-22 20:33:26 @hholdenthorp @alanalda I love @alanalda Here's is our back and forth after I got the @ScienceMagazine review back for Covid and the heart https://t.co/Ql4PIA6rBE
2022-09-22 18:58:28 Why is obesity an important risk factor for severe Covid?@ScienceTM, a potential contributing factor #SARSCoV2 infects fat cells -->
2022-09-22 18:19:06 Discovery of a Sarbecovirus (Khosta-2) in Russian bats resistant to neutralization in serum from people who had Covid vaccineshttps://t.co/XTdua8Hwa0 @PLOSPathogens "Our findings ...underscore the urgent ned to develop broader-protecting universal sarbecovirus vaccines" https://t.co/oRRfPOrn4A
2022-09-22 17:15:38 A big brain dayhttps://t.co/M62pTCsKFf @ScienceMagazine @ScienceInsider Congrats @JoeEcker @salkinstitute to lead $126M effort to map aging human brainAnd a report @TheEconomist https://t.co/sS02x3pV2f @natashaloder https://t.co/LMSk5hSdOM
2022-09-22 16:59:00 RT @firefoxx66: What should we expect from #SARSCoV2 this autumn?I think it would be smart to prepare for both an increase in #COVID19 du…
2022-09-22 16:08:02 Some context:—77% White males (Veteran population), so generalizability—<
2022-09-22 15:05:02 Here's the breakdown by risk of outcome and excess burden per 1,000 people https://t.co/rwCEybLbk5
2022-09-22 15:03:08 @NatureMedicine Comprehensive analysis of #LongCovid neurologic outcomes at 1 year from >
2022-09-22 14:11:19 Congratulations @demishassabis @DeepMind for being awarded the Breakthrough Prize today #AlphaFold #AIhttps://t.co/kZSwCaOWwc"Few discoveries so dramatically alter a field, so rapidly” --@MoAlQuraishi
2022-09-22 14:00:12 The true pandemic death toll is currently ~22 million, not the official 6.5 million https://t.co/57lVnlqOPIMarked variance in official vs excess mortality between countries https://t.co/iCyz9XSYlU
2022-09-22 13:38:29 I don't usually agree with Paul Offit on his booster take but he makes a few good points herehttps://t.co/MzWuOJ4yu7 https://t.co/WeekdGZdQg
2022-09-22 13:35:30 New neutralizing antibody data for BA.1 and BA.5 boosters, monovalent or bivalent, in micehttps://t.co/xlSWTEh6st @BioNTech_Group BA.5 better than BA.1 (for BA.5 counter)
2022-09-22 13:14:40 Our Covid times :-)by @Walt_Handelsman https://t.co/U5QjdLm4nj
2022-09-22 02:45:04 Here is a graph showing the current growth advantage of BQ.1.1 and BA.2.75.2 relative to BA.5.2* in the UKhttps://t.co/wbicHdEOqX https://t.co/5fs2qBgWhD
2022-09-21 23:50:04 RT @thrasherxy: In its most lethal year, 1996, AIDS took about 1,100 lives in the United States each week. Last week, COVID took at least…
2022-09-21 22:45:55 Recovery >
2022-09-19 01:43:20 @meganranney Thanks Megan!
2022-09-19 01:02:26 Or that only 1 of 3 Americans have had any booster shot. A proclamation "it's over" is not going to help that https://t.co/oSnWZYX75g
2022-09-19 01:02:25 And what about the 400-500 Americans dying each day since April https://t.co/LduqLo6Iu2
2022-09-19 00:38:26 Wish this was true. What's over is @POTUS's and our government's will to get ahead of it, with magical thinking on the new bivalent boosters. Ignores #LongCovid, inevitability of new variants, and our current incapability for blocking infections and transmission https://t.co/sZyChorhC9
2022-09-19 00:28:03 @TheLizArmy Much appreciated and fully identify with you
2022-09-19 00:00:32 @terrawellington Great question. We need to push our government hard to invest in more durable and effective, variant-proof nasal sprays and shots. Instead of wasting $ billions on >
2022-09-18 18:14:51 For now: get a booster. It's the best shot you have to stay maximally protected (unless you had BA.5). It's worth the early side-effectsFor the future: we need a better strategy that prevents infections, transmission (ergo #LongCovid) and is far more durable, variant-proof
2022-09-18 18:14:50 12. There are no data to show durability of boosters vs severe Covid beyond 4-6 months. Or to even show that the new (? more potent) bivalent Omicron BA.5 will perform better than original or BA.1 bivalent boosters. A ≥ 2-time booster strategy per year is untenable, long term.
2022-09-18 18:14:49 11. Figures from the outstanding threads by @EllingUlrich and @yunlong_caohttps://t.co/EYv2j5wrVYhttps://t.co/58GWiHN9Ahthat suggest imprinting as at least part of the explanation for this observation https://t.co/s0H4G0Ehhx
2022-09-18 18:14:48 10. Is this because Omicron BA.1 is less immunogenic or because of imprinting (responding preferentially to 1st exposure strain)?Same pattern of reduced antibody response in mice (and humans) to BA.1 and BA.5 compared with ancestral https://t.co/OLJCIWdldP
2022-09-18 18:14:46 9. Let's zoom in further on these data (here's the fog part)The antibody response to Omicron BA.1 (geometric mean titer) was multi-fold less than against the ancestral strain for the bivalent or original booster https://t.co/15WrhxFGA6
2022-09-18 18:14:44 8. Yet the overall data to support the need for boosters is clearcut. What about the bivalent Omicron vaccine that matches up to BA.5 (and BA.4.6) that account for ~99% of American cases?The data for a BA.1 bivalent vaccine was published @NEJM 16 Sept https://t.co/3ZJXrOchHh
2022-09-18 18:14:43 7. More on lack of enthusiasm for new bivalent Omicron boosters (actual data to be released this week)https://t.co/cgfn3roAhb @NPR by @nprscottsimon @robsteinnews https://t.co/Vo6yJucG8K
2022-09-18 18:14:42 6. Today's NY Times front page https://t.co/cJOWj5pIzEby @jackhealyNYT @sharonNYT @amyyqin Reasons: lack of perceived benefit, reactogenecity side-effects, unaware, "it's over"I'll come back to "potent" subsequently https://t.co/tWjakyDUYi
2022-09-18 18:14:40 5. So why haven't the majority of even high-risk (age 50+) gotten a 2nd booster? Updated datahttps://t.co/YBz9U1MBA4 https://t.co/unpmxhLE2N
2022-09-18 18:14:38 4. There is also evidence that boosters help protect vs #LongCovid (point estimate 84% reduction for 3 shots in this cohort of health care workers)https://t.co/IAuQCZs6bl https://t.co/T33YZHq1VD
2022-09-18 18:14:36 3. The magnitude of benefit has been consistent over time, for different Omicron subvariants. Here in May, across all ages, H/T @redouad, 96% reduction of death for 4 shots vs unvaccinated https://t.co/oetnzuCikH
2022-09-18 18:14:34 2. The most recent @CDCgov data, compared with unvaccinated, age 50+4 shots: 94% reduction of death3 shots: 83.5% reduction of death https://t.co/ZXvVOKOhEb
2022-09-18 18:14:33 Lifting the booster fogThe evidence supporting boosters is incontrovertible. Summary of data for 4th vs 3rd shots for survival benefit, age 50+The unequivocal benefit is for enhanced protection vs severe Covid https://t.co/2Gpaxq8xlM
2022-09-18 15:19:13 @CarlHoefer1 @AlpertReyes @a1daylanan @mtosterholm Read the article
2022-09-17 20:49:26 This IS good news and aligns well with many prior report vaccination-mediated reduction (≥40%) of #LongCovid But to *prevent* this we need to block infections and transmission. As the virus evolved, that's unlikely to come from shotshttps://t.co/HqzfKW3JCk https://t.co/JiEAqC08T2 https://t.co/JUvJnk6ucm
2022-09-17 19:01:25 When hallucinating can be a good thing......"Our results highlight the rich diversity of new protein structures that can be generated using deep learning"https://t.co/085N9nDqFd @ScienceMagazine @UWproteindesign @BasileWicky #ProteinMPNN #AlphaFold #AI https://t.co/aVQe1uqeVN
2022-09-17 18:11:10 It’s “a landmark study in the treatment of autoimmunity” —Aimee Payne @PennMedicine https://t.co/QKkstwc7AL @ScienceMagazine @jcouzin
2022-09-17 17:06:26 This thread is rich with new insights about imprinting in response to BA.5 breakthrough infections (relative lack of nAb response), and for the BA.2.75.2 variant pinpointing the mutations that help explain its immune escape https://t.co/SzcTYViNKN https://t.co/0oUIdbJIlZ
2022-09-17 15:13:10 Here's the preprint by @BenjMurrell and colleagues now posted, summarized in his threadhttps://t.co/6kuQCL8AJs"BA.2.75.2 was neutralised...five-fold less potently than BA.5... These data raise concerns that BA.2.75.2 may effectively evade humoral immunity in the population."
2022-09-17 03:31:35 @MikeMadden Not to worry. It would take a couple of months for this one or an alternative to become dominant, even with exponential growth
2022-09-16 20:27:54 Independent replication BA.2.75.2https://t.co/AovxlrORTx
2022-09-16 20:17:10 This is one of the main BA.2 new variants to be concerned about, with real immune-evasive potential to outcompete BA.5 https://t.co/nE5OdNBYsl
2022-09-16 20:11:07 @BenjMurrell I'm with you on this, Ben. Very concerned about BA.2.75.2
2022-09-16 18:41:26 "if just 5% ultimately fulfill criteria for #LongCovid, that means 7.5 M individuals would be affected in the US. In comparison, each year in the US, ~1.8 M individuals are diagnosed w/cancer and 1.5 M are diagnosed w/ diabetes."https://t.co/SrtRtGsYCD@Health_Affairs https://t.co/fww1YTcF6o
2022-09-16 18:14:52 If it's a 1-pager, it's simple stuffhttps://t.co/jJ8SMZaS5R @CellCellPress @WickstromLab @WickstromLab https://t.co/n8K9L5LNJj
2022-09-16 18:06:22 The remarkably prominent and diverse role of macrophage cells in the heart continues to grow. A new, well done review @ImmunityCP https://t.co/kk9NYwIBVI by @rysa_zaman @EpelmanLab @UofT @uoftmedicine https://t.co/F6g5tdnQ5f https://t.co/gf4gAhupjb
2022-09-16 17:44:24 @berthacoombs Unfortunately, I think it's unlikely to provide longer (>
2022-09-16 16:54:41 Latest report of BA.2.75 https://t.co/kNqdzC0PiNAnd thread on prior oneshttps://t.co/awxz6JydTV https://t.co/t2SOHzrf0z
2022-09-16 16:40:20 BF.7 is BA.5.2.1.XBA.2.75 (spike mutations below, H/T @PeacockFlu ) isn't as concerning as further BA.2 derivatives BA.2.75.2 acquired 3 more key spike mutations, more immune evasion potentialNB: The virus is still showing substantial signs of evolution
2022-09-16 16:24:54 The latest US genomic surveillance data shows another small gain of BA.4.6 but, for the 1st time, past the 1% threshold of BA.2.75 and BF.7https://t.co/jjl2AnOYb5 https://t.co/HzwoPmIyre
2022-09-16 16:06:15 No differences in reactogenicity/safety between original and bivalent Omicron booster(this is an issue which needs to improve and discourages people from getting booster shots) https://t.co/vRFcIC3G18
2022-09-16 16:02:39 Just out @NEJM The bivalent ancestral/BA.1 Moderna vaccine as a 2nd booster vs original boosterhttps://t.co/tlZQSJaTTi~2-fold increase of neutralizing antibodies vs BA.1, BA.5, no effectiveness data https://t.co/FqHikImL19
2022-09-16 14:03:15 The danger of Covid vs fluFact-free viewshttps://t.co/dCZC9uqkS8 @NPR @robsteinnews Facts by @ProfPCDoherty https://t.co/lQoju88xDK https://t.co/Asua2czmBX
2022-09-16 13:50:25 It's exciting to see the powerful impact of CRISPR genome editing "In the low-dose group, the one-time infusion also reduced by 91% the painful swelling “attacks” commonly experienced by patients with a rare condition called hereditary angioedema"https://t.co/SfC6squo9G https://t.co/Qxl1kwVd56
2022-09-13 03:11:04 I posted an addendum to clarify misinterpretations that I have undervalued the profound contributions of human genomics.
2022-09-12 23:29:47 @MelissaServedio @SSI_dk @GKPedersen @eBioMedicine No.
2022-09-12 22:55:39 A Covid shot prime and nasal vaccine boost significantly reduced upper airway viral load and transmission in an experimental model, w/ perspective on other shot plus nasal vax booster clinical successhttps://t.co/wpaudojNbP @SSI_dk @GKPedersen @eBioMedicine https://t.co/lAsigX4DdX
2022-09-12 22:34:35 The protection derived from a 4th shot mRNA booster in ~40,000 people age 80+ in Singapore, compared w/ ~40,000 matched controls with 3 shots, during its BA.2 and BA.5 waveshttps://t.co/mHohjlT2lx @AnnalsofIM https://t.co/t6kpxAwnZp
2022-09-12 21:23:07 The road to cancer cures may go through the nervous system. An astute perspective on cancer-neuroscience interactions @NatureCellBio https://t.co/T4wEDD0O9B by @ChenchenPan1 @Winkler_Lab https://t.co/AGKX3CQP0z
2022-09-12 19:59:36 The paper was mistakenly put behind a paywall, which has now been corrected. Here's the link https://t.co/rYT7Hsf2jH
2022-09-12 18:17:03 A 2nd paper today with more results from this cohort on physical activity and cadence, specifically for association with cardiovascular and cancer events during follow-uphttps://t.co/qPenxKQoSO @JAMAInternalMed https://t.co/KElFmqRyga
2022-09-12 17:52:24 RT @DKThomp: This is really exciting: I'm talking to @EricTopol tomorrow afternoon in a live interview about the future of medical innova…
2022-09-12 16:11:13 A new and outstanding review of Covid/#SARSCoV2 in immunocompromised individuals https://t.co/51TMhVW1Kd @ImmunityCP @dewolf_susan @SantoshVardhana @MSKCancerCenter https://t.co/1UBQ9BzLiH
2022-09-12 15:45:49 From combining genetic data in over 730,000 people and 80 diseases burden estimates:"Genetic risk factors can explain a sizable number of healthy life years lost both at the individual and population level"https://t.co/ggljmkcmHG @NatureMed @andganna @DrSakari @FIMM_UH https://t.co/rUI1Ua3mIP
2022-09-12 00:57:50 RT @McFaul: Ukrainian warriors are humiliating Putin and his generals.
2022-09-12 00:40:00 The chasm between knowledge and practice needs to be addressed https://t.co/SU49gPt8RZ
2022-09-12 00:02:30 RT @mor10: "COVID is over" they say as the pandemic burns through the population making people sick, giving people chronic illness, killing…
2022-09-11 20:18:41 More than 20 years after the 1st human genome was sequenced, there's relatively little to show for it in clinical practice. https://t.co/NmbW8oqtLc
2022-09-11 17:14:28 I don't think so:"In a not-too-distant future, your Prime membership may include a free annual checkup."https://t.co/5Q8JeqlYPp by @david_wainer https://t.co/dOMwe7Fxgr
2022-09-11 16:22:29 Don't be numb to thishttps://t.co/t2x5LYfzZc by @jon_kamp https://t.co/qZlKRLrBdZ
2022-09-11 15:39:35 "The U.S. shouldn’t live with covid. It should get beyond the virus."https://t.co/u0USbACt9aOn annual shots working: "that is a massive if""The nation needs a massive push to create a universal coronavirus vaccine against all variants and for a long duration." https://t.co/5ABsPsdhoO
2022-09-11 15:19:18 The first organ transplant in the US was in 1954.Now there have been 1 million.105,000 people are on the waiting list.~17 die each day waitinghttps://t.co/5luRM9owWJ by @LNeergaard @APHealthScience https://t.co/zhMZXLJzoR
2022-09-10 22:40:42 "These findings highlight the need to develop vaccines that enhance nasal immunity."https://t.co/MkDNgpb6HT @FelicityLiew @p_openshaw @LanceTurtle @InThwaiteImmune and colleagues https://t.co/CXVvcVF3Yo
2022-09-10 19:28:25 RT @EricTopol: We'd never met someone w/ degrees in math, physics, history (2), and expertise in health data scienceProf Christina Pagel @…
2022-09-10 18:53:42 Superior antibody vs variants of concern and T-cell response for nasal vaccine (i.n.) compared with shots (s.c.)https://t.co/YmX3XHML6y @StJohnLab @dukenus @justsaysinmice https://t.co/VThK88lwSS
2022-09-10 18:24:48 And this by @maryhul @QZ is chillinghttps://t.co/dSjnHSMAr7 https://t.co/JCvF0acvg2
2022-09-10 18:24:47 Across the board, worst for Native Americanshttps://t.co/1antdOz14w by @germanrlopez @ashhwu @nytgraphics https://t.co/GkDVpAJZOW
2022-09-09 19:55:05 Does when you load calories during the day help with weight loss? A randomized, crossover trial says no https://t.co/pUJPMk7FUF @Cell_Metabolism https://t.co/bDmqe3f2iX
2022-09-09 19:23:06 We'd never met someone w/ degrees in math, physics, history (2), and expertise in health data scienceProf Christina Pagel @chrischirp is a leading information &
2022-09-09 18:38:30 Latest US #SARSCoV2 genomic surveillance: 89% BA.5, 9% BA.4.6Slow growth of the latter, ~1%/week, and overall decline in cases No other variants at appreciable levels https://t.co/cVICaeqetJ
2022-09-09 17:49:01 RT @chrischirp: Delighted to chat to @EricTopol and @cuttingforstone at length about maths, physics, history, my day job - and mostly - Cov…
2022-09-09 14:39:52 Hey, U.S., is this the best you can do?“At this point, we know another variant is coming — we just don’t know when,” a senior administration official said. “Our job is to make [the vaccine] available. And then people can do what they want.”https://t.co/1dK0FAoEUJ@adamcancryn
2022-09-09 14:14:49 The comprehensive list of validated treatments for ME/CFS and #LongCovid.This has to change. https://t.co/qW2wMapwVq
2022-09-09 14:03:33 In this thread, @chrischirp provides a useful summary of the responses for each of the 6 salient topicshttps://t.co/NbESV9XOIG
2022-09-08 23:11:36 A single amino acid change helps explain our cognitive power compared with Neanderthals!https://t.co/MnvqZxeyVwhttps://t.co/iJ5etwtnsI@ScienceMagazine And a @carlzimmer explainerhttps://t.co/njk0bQqbt6 @NYTScience https://t.co/Gq1NwEaboZ
2022-09-08 22:38:50 RT @ProfPCDoherty: It's important not to 'push through' with high level fitness activities if you've had mild COVID and, months later, your…
2022-09-08 19:12:37 As opposed to what is generally thought (from under-reporting sequence variation of Covid samples)......"Our study has revealed significant within host infection diversity of #SARSCoV2 through full genome sequence analysis."https://t.co/22Ab1H4dl0 @PLOSGenetics https://t.co/mErDXuNoCZ
2022-09-08 18:24:57 Quite the @ScienceMagazine feature on Covid and children with key questions and insightshttps://t.co/OpTu7vWJlG@AldertonBiol w/ @chrischirp @dgurdasani1 @BinitaKane @carlpierce @PeterHotez @sarahcobey @scotthensley https://t.co/JpDwJTqRM8
2022-09-08 18:07:08 Full text here https://t.co/vtrwAWD9kF
2022-09-08 18:07:06 Excellent, succinct review of myalgic encephalomyelitis (ME/CFS) and its overlapping features with #LongCovid @ScienceMagazine https://t.co/CipzsAdv2r https://t.co/nSAfeCU9eL
2022-09-08 16:43:49 Missed opportunities in the U.S. The intellectual property for multiple Covid nasal vaccines was licensed to companies in other countries, such as that of @WUSTLmed to @BharatBiotech https://t.co/YrV9ojPWpH https://t.co/clrbrUUDiQ
2022-09-08 16:36:06 Seeing the invisible by expansion microscopy and #AI intelligent microscopy https://t.co/vo88mCIQMS@TheEconomist @eboyden3 https://t.co/l9leXjhDAk@naturemethods @SulianaManley @EPFL_en https://t.co/HD3uLt2FNg https://t.co/KyXAhqOX49
2022-09-08 14:52:09 New research initiative on #LongCovid root causes @research_long @polybioRF @microbeminded2 https://t.co/8BCJXXeL9D@rddysum https://t.co/Olx9gDzUYK @lukemmoney https://t.co/VxAMtM0dgb
2022-09-07 23:00:36 More on the risk of artificial sweeteners ascertained through a large (>
2022-09-07 22:10:07 2 more reports characterizing BA.2.75https://t.co/0Q16FPfXw4 @cellhostmicrobe https://t.co/jt1p9uuLUv @NEJM But the concern is now shifted to BA.2.75.2, which has acquired 3 more key spike mutations, more immune evasion, see @PeacockFlu &
2022-09-07 21:44:34 @JaneEspenson @NEJM Yes, for sure, in high-risk people. There is no question of Paxlovid's high efficacy—protection vs hospitalizations and deaths—despite the occurrence of rebound in some (per cent still unknown) people
2022-09-07 21:19:47 How well does an original (ancestral strain) mRNA booster hold up vs BA.5 over time for neutralizing antibodies?https://t.co/W00tJM8bZW @NEJMNot well, especially in people without breakthrough or prior infections https://t.co/S08OQzpRSJ
2022-09-07 21:11:56 A small, in-depth study of Paxlovid rebound demonstrates high viral load with symptoms or positive antigen tests—which supports infectiousness— along with occurrence in 5 of 13 families, suggesting it is not uncommonhttps://t.co/Zqz8kaZpT4 @NEJM https://t.co/ot8yVTTu3G
2022-09-07 16:56:50 Why do people have a high affinity to fat in their diet?https://t.co/VwqKEDhZF8Discovery of a gut-brain axis with distinct cells and receptors for fat perference, not indexed to taste@ColumbiaMed @nature @justsaysinmice https://t.co/Iux0q2jmQR @HHMINEWS https://t.co/G48CUANIDc
2022-09-07 14:40:16 @cshperspectives This adds to where we stand now in [not] protecting Americans who are immunocompromisedhttps://t.co/6xoOO1MbZH https://t.co/lxySNXBi5b
2022-09-07 13:50:27 A new report confirms BA.4.6's (now ~10% in US) immune escape, loss of Evusheld sensitivity"The loss of activity of tixagevimab and cilgavimab against BA.4.6 leaves us with bebtelovimab as the only therapeutic mAb that has retained potent activity"https://t.co/6zIY01Fi0w https://t.co/pJE1BfaHnW https://t.co/IJ2RkH1Eow
2022-09-07 13:31:53 @yunlong_cao @CorneliusRoemer @chrischirp @TheLancetInfDis @BenjMurrell @PeacockFlu @DannySheward Quite concerning. Look forward to reviewing the data Thank you
2022-09-07 02:25:34 What is the prevalence of #LongCovid with the BA.5 variant? A new report from US, June-July, w/o controls, is the first crack at the question: 21.5% had symptoms >
2022-09-06 22:39:03 More good news on BA.2.75, replicating and extending the prior (attached) reporthttps://t.co/duCTPI7c5s"antibody escape is an overall less pronounced characteristic of BA.2.75 compared with BA.4/5"@TheLancetInfDis https://t.co/9SszCrYNkB
2022-09-06 22:21:21 @FlyingFish06 @GradyMcGregor @cansinobio_inc It was there, now removed. The author, @GradyMcGregor, should respond
2022-09-06 21:59:32 @lexbyanyname @leozh @HMogan24 @scottshanno @loriand95467435 @lehudgins Yes, the lowest estimate was 15% reduction, from this reporthttps://t.co/2JUuTatett
2022-09-06 21:47:18 The U.S. hasn't really even tried https://t.co/OEhpuFFenL by @GradyMcGregor Meanwhile 1 breath of @cansinobio_inc's inhaled vaccine booster was better than a 3rd shot vs Omicron for neutralizing antibody response (92% vs 0%) at 4 weeks
2022-09-06 21:31:45 @CarlosdelRio7 on "boosting our way" out is untenable, but to give a false impression of year-long protection (vs severe disease and death) with the data in hand is not acceptable. There are multiple ways this can be achieved, and the US is not actively aggressively pursuing any of them.
2022-09-06 19:43:34 I've previously addressed the vital need for variant-proof &
2022-09-06 18:50:25 Just tweaking the lipid nanoparticles could make a big difference"There is still so much optimization and development that needs to happen"—@AnnaBlakney "There's a huge amount of RNA that's not being used"—@sahayg1https://t.co/Q3wiygjRcd by @ElieDolgin @ScienceMagazine https://t.co/3ZT4fOkNeo
2022-09-06 18:24:35 This has the ring of Covid capitulation https://t.co/9boHwQ6nYiI'm certain we can do better than this. The science foundation is there for multiple paths of extended durability and enhanced protection. The will is not. https://t.co/iBMu0mcqRa
2022-09-06 18:12:59 @Laurie_Garrett Agree, Laurie
2022-09-06 17:40:44 I don't see any evidence for how an annual Covid shot will provide durable protection (current ones wane after 4-6 months) without better vaccines, such as variant-proof, improved nanoparticles, and nasalhttps://t.co/uytgskKKN9 https://t.co/knjhSjNELL
2022-09-06 16:51:28 Discovery of new antibiotics is critical to deal with the resistance issue. Hope this would be accelerated with the use of #AlphaFold is tempered by this new @EMBOPress report https://t.co/rydDsMeE6v by @MIT_IMES @MITdeptofBE https://t.co/BVqn1gh69n
2022-09-06 16:34:35 @HenrikVogt Wrong. You have completely misinterpreted and twisted what I wrote. I simply pointed out that the symptoms of the Yale/Mt. Sinai study participants tracked tightly with the multiple molecular biomarkers they assessed.
2022-09-06 15:05:31 The link between physical activity (steps) and avoidance of dementia A new @uk_biobank study of over 78,000 people showed largest decrease for >
2022-09-06 14:10:54 Timely feature @Nature : How nasal spray vaccines could change the pandemic https://t.co/R9xcvCe0qlby @EmWaltz https://t.co/ml8tfxUOVB
2022-09-06 13:32:35 Nasal and oral vaccines are our best shot to block infections, transmission, achieve containment of the virus, reduce the toll of sickness, &
2022-09-05 16:47:04 RT @VirusesImmunity: Very happy to see that China approved the world’s first inhaled vaccine against COVID-19. Convidecia Air is an aerosol…
2022-09-05 16:43:38 First inhaled Covid vaccine approved, with improved Omicron antibody response as booster to 2 shots (Coronavac) compared to 3 shots https://t.co/3MtEgb7Rro by @GradyMcGregor
2022-09-05 16:22:25 @HoffmannJedrzej @NatureMedicine @v_puntmann @AShchendrygina @c_eike @AndreasZeiher @GoetheCVI Such an important study to help us understand cardiac implications and ties to symptoms during extended follow up in a selected cohort of mild Covid, with controls. Thanks to you and your colleagues
2022-09-05 15:27:18 The main symptom was difficulty breathing with exertion
2022-09-05 15:13:51 "The imaging findings suggest that inflammatory cardiac involvement after COVID may be a pathophysiological commonality shared among all individuals, regardless of the expression of cardiac symptoms" https://t.co/NuA9h9CXIL
2022-09-05 15:13:49 @NatureMedicine Heart manifestations of #LongCovidA prospective MRI study of 346 people with mild Covid, and controls, demonstrated myocardial inflammation at 3 months, worse w/ symptoms, and edema at ~1 yearby @v_puntmann and colleagues @GoetheCVI https://t.co/TjrAJphYCh https://t.co/RxlRyHCcZ1
2022-09-04 19:54:22 Entry of #SARSCoV2, with viral membrane fusion and transfer of the genome to the cytosol of the cell. Requires an acidic pH (nasal pH in 17 healthy participants was 6.6)https://t.co/As5p6jg7JO@PNASNews https://t.co/7LoyTJyCf0
2022-09-04 18:18:08 Vaccine breakthrough infections teach us about the upper airway T-cell immune response, its durability, and hybrid immunity. Yet another indicator of what nasal vaccines could achieve instead of breakthrough infectionshttps://t.co/12cocEJ8MK @JExpMed by @bertoletti_lab https://t.co/XYkPrD9KA3
2022-09-04 00:45:15 @LongDesertTrain It's certainly possible, Ryan. Which is why I wrote "several" instead of "many" weeks respite and emphasized variant-chasing isn't the right strategy.There's also the BA.2.3 you've spotlightedhttps://t.co/ez2XHPwhPX
2022-09-03 19:29:07 The new bivalent boosters are already available in many drugstores around the country. The BA.5 spike protein mRNA comprises 15 μg for Pfizer and 25 μg for Moderna https://t.co/mf2Leop05q
2022-09-03 18:51:22 The new bivalent BA.5/ancestral booster may help restore that and could also improve protection vs infections and transmission. But we won't know that for several weeks /5https://t.co/BR54il19st
2022-09-03 18:51:21 What is concerning to me is to see the decline in vaccine effectiveness vs hospitalizations for BA.5 compared with the prior Omicron subvariants /4https://t.co/64b9g7HW1h https://t.co/7fzohLYZ7X
2022-09-03 18:51:20 Please be aware there's still lots of circulating virus, ~90% of which is BA.5 out thereOnly BA.4.6 is slowly competing at an appreciable level, recently ~1% growth/ weekLatest transmission map /3https://t.co/S0JGpwehtc. . https://t.co/v0bcuHFCZH
2022-09-03 18:51:18 The US metricsExcept for deaths that remain at a ~500 deaths/day plateau, all are pointing in the right directionCases are notoriously under-reported, but we are at the lowest level in 4 months, (that number of confirmed cases, 78K, is still very high) /2 https://t.co/BYmoS9p3IH
2022-09-03 18:51:17 The BA.5 variant wave is in descent in the US and throughout the world. Without a threatening new variant that exhibits ability to strongly compete now, we should have several weeks of a respite World cases/ deathsJapan, one of the last to get hit, still on the rise for deaths https://t.co/pq4fkpYEoF
2022-09-03 16:49:29 The involvement of endothelium, the lining of blood vessels, is an important underpinning of #LongCovid's pathophysiology. An impressive review paper @jclinicalinvesthttps://t.co/TYLx2ZsZZF https://t.co/w1OMf3Y2ah
2022-09-03 01:16:54 @CarlosdelRio7 Yes, Carlos, because it has no real competition. That may be good, and help us avoid a new wave for many weeks. I don't want to see a variant that can rapidly out-compete BA.5!
2022-09-02 20:57:18 Very good #LongCovid review of what's known on mechanism, sequelae and treatments. One edit from me on the title https://t.co/Rs6Filotob@PNASNews by @LeahabShafferWe urgently need to get treatments validated https://t.co/F5XvBrAIof
2022-09-02 18:44:06 One of the big biomedical advances this year was the report that multiple sclerosis is caused by the Epstein-Barr virus. A new essay @jclinicalinvest says not so fast, the strong evidence was restricted to one grouphttps://t.co/1xmbTJV1DV by @ihorwitz@Idasim and colleagues https://t.co/bO0LTBUyx6
2022-09-02 18:15:06 @AWeissmann_ Somehow "classified" and "empty folders" doesn't seem to go together very well
2022-09-02 17:27:56 "Our study demonstrates an unexpected role for GnRH [gonadotropin-releasing hormone] in olfactory &
2022-09-02 16:23:35 some more on backgroundhttps://t.co/ApmNy5w7S6
2022-09-02 15:11:20 BA.4.6 (in blue) shows a lot of regional variation https://t.co/BjcE3uJrev
2022-09-02 15:11:18 Latest US genomic surveillance data posted shows BA.5 at 89%, BA 4.6 at 8.4% (slow growth) and no detection at appreciable levels of a new variant https://t.co/jjl2AnwOWX https://t.co/CNV3zZfjft
2022-09-02 14:41:29 To efficiently block Covid infections and transmission, we need to get high levels of secretory IgA, reflecting mucosal immunity. Important work by @florian_krammer and colleagues
2022-09-02 14:16:00 "Equivalent of a James Webb Space Telescope for biology," now predicting 3D structure of >
2022-09-02 01:57:48 An indefatigable force throughout the pandemic, @trishgreenhalgh goes deep to understand the big miss—that #COVIDisAirborne https://t.co/erqAF4iAiB@BMJ_latest w/ @DRTomlinsonEP and Mustafa Ozbilgin https://t.co/i5oX0kQw2Z
2022-09-01 23:06:56 Sone good news about the BA.2.75 variant, in case it gets legs: it's not more immune evasive than BA.5, has cross-immunity w/ BA.1/2, and is still sensitive to Evusheld and Bebtelovimabhttps://t.co/EgnyuWpCYm @TheLancetInfDis @BenjMurrell @PeacockFlu @DannySheward &
2022-09-01 21:03:26 "A Gut Reaction" A nice explainer published today @CellCellPress on this important study https://t.co/YC9RqQx7XC https://t.co/gUKqe42NWr
2022-09-01 17:30:08 Some slippage of vaccine protection vs BA.5 hospitalizations is concerning, reflects its immune escape, and there's hope for bolstering by the new boosters. As previously noted, it ought to prompt aggressive efforts for pan-sarbecovirus and nasal vaccineshttps://t.co/vwK1ZXsU7m
2022-09-01 17:01:20 Aligns with this @nature summary and perspective of a recent analysis by @DebCro @KirbyInstitute that suggests there may be little difference between the 2 bivalent vaccines (BA.1 v. BA.5) https://t.co/iqA2L2qPp7https://t.co/cejMclUDLu by @ewencallaway https://t.co/JW5uEcYvth
2022-09-01 16:18:26 Data also presented for protection vs BA.5 symptomatic infection for age 50+ (by booster dose and over time) https://t.co/lr1mzJulKq
2022-09-01 15:50:26 New data at today's CDC/ACIP meeting on vaccine effectiveness vs BA.5 wave hospitalizations, all adultshttps://t.co/64b9g7HW1hLess protection for both 3rd and 4th dose vaccines compared with the prior wave (BA.2, BA.2.12) https://t.co/JTichjw2I3
2022-09-01 15:36:55 And in mouse model challenged with BA.5 virus, similar impact for the 2 bivalent vaccines, better than original (ancestral) vaccine https://t.co/syanLPV1ni
2022-09-01 15:36:54 First look at BA.5 bivalent booster vaccine data from @moderna_tx, only in mice, at today's ACIP meetinghttps://t.co/8cZMlkWCmuNeutralizing antibody response similar to BA.1 bivalent vaccine https://t.co/g6KuRGt0pM
2022-09-01 01:59:32 RT @MaryPeltola: My position on the right to choose is simple: our government should not be in the business of telling people what they can…
2022-08-31 23:23:56 @pelagicbird @GretchenVogel1 @ScienceInsider @ScienceMagazine @lauriemcginley2 @washingtonpost @PostHealthSci Correct. I pointed that out too and still do not understand why we aren't going vs BA.5 only https://t.co/BR54il19st
2022-08-31 23:22:09 There's one country that doesn't get what it pays for, which preceded the pandemic https://t.co/7PaLGyglVTNow >
2022-08-31 22:36:50 Congratulations to @yuwang_15 for this groundbreaking workAnd the —seeing is believing—video https://t.co/W05gz13l7B
2022-08-31 22:29:56 Good to see for JapanStart of BA.5 wave descent for fatalities @OurWorldInData Japan has one of, if not the, lowest cumulative (and excess) mortality rates of large population countries in the world with rigorous tracking https://t.co/W1GR7Jdmtp
2022-08-31 22:09:12 @molly_knight @doctorsoumya @MommasGoneCity Thanks for sharing the horrible ordeal of what you're going through and so glad you're seeing some improvement. POTS is real as a #LongCovid serious sequelae, despite the denialism out there, and vaxx/boosters cannot be relied upon to protect
2022-08-31 21:27:32 A new, very good Covid vaccine review article @NEJM https://t.co/xglkQ5HQCO by @BarouchLab "Current Covid-19 vaccines are less effective at blocking infection with the omicron variant than ... prior variants, but protection against severe disease remains largely preserved." https://t.co/APj8UwoK6f
2022-08-31 21:01:28 Full text and table from supplemental for context https://t.co/tMVa93K8ga
2022-08-31 21:01:26 A Portugal nationwide study shows prior infections with BA.1 and BA.2 protects better vs BA.5 than earlier major variants, in a highly vaccinated population https://t.co/JuxIzrDZIFThat's good since previous data was unclear for BA.1/2 and there were a lot of these infections https://t.co/bfzrI5sk8B
2022-08-31 16:54:32 2 helpful articles on the questions surrounding the new boostershttps://t.co/K9RGJb7N8g by @GretchenVogel1 @ScienceInsider @ScienceMagazine https://t.co/eRibjK3CsU by @lauriemcginley2 @washingtonpost @PostHealthSci https://t.co/BOSWMCv9kM
2022-08-31 16:39:42 How fat tissue talks to the brainThe dogma was it occurred slowly through hormones. Now there's proof it occurs rapidly through neurons.https://t.co/Uh1c3L1rWtby my colleagues @scrippsresearch @liye_tsri@ardemp @Nature https://t.co/RDw6l8xeLf
2022-08-31 16:19:18 @Nature On autoimmune features of #LongCovid "..autoreactivity persists in a subset of patients w/post-acute sequelae, raising important questions...emerging autoreactivity to ongoing symptomology upon recovery"https://t.co/xyGIqRQYrkExtrapolated via patients w/severe Covid https://t.co/Hv43gMERvC
2022-08-31 16:03:13 Relevant to new BA.5 boosters for people with recent infection <
2022-08-31 14:19:14 No surprise hereBut it’s not a straightforward decision https://t.co/BR54il19st https://t.co/iB7SZa4Ns4
2022-08-31 13:42:53 This precipitous drop and current level is substantially worse than 21 peer countrieshttps://t.co/NAEMjhs4j3 https://t.co/QhrZ1Xnwcr
2022-08-31 13:38:27 That's one way to counter Covid mis/dis-information from doctorshttps://t.co/bE5XVLgI4m @stevenleemyers https://t.co/0YSyJL1u2f
2022-08-31 12:50:05 The historic drop in US life expectancyBiggest two-year decline —2.7 years in total — in almost 100 yearsNow 76.1, the lowest in 25 years Levels at 1944 for AIANPandemic, accidents and overdoses were 1° drivershttps://t.co/0Z9TQIIXRwhttps://t.co/3iFlziN2Xk https://t.co/relDFO7Xhb
2022-08-31 03:52:05 @kyledcheney a picture worth a thousand(s) of [secret] words
2022-08-31 00:34:50 A digital, site-less, smartphone app, randomized clinical trial detected more than 2-fold atrial fibrillation warranting blood thinners compared to usual carehttps://t.co/HCCCfLXfQs@NatureMedicine https://t.co/u6TTkByW1M
2022-08-31 00:01:16 @CatchTheBaby @StephenAtHome Thanks Ruth Ann! Not sure how I goofed to get the link wrong
2022-08-30 23:47:49 RT @JusDayDa: @EricTopol @OurWorldInData Last 12 months... https://t.co/rk4bWpb7pU
2022-08-30 21:41:50 A colleague just sent me this video segment I did with @StephenAtHome from nearly a decade ago. It brought back some fun and funny memories https://t.co/Dc0gRFET3B
2022-08-30 21:18:51 @Andr3wW1l3s @acweyand Deeply appreciated
2022-08-30 20:14:44 Missed RussiaThanks for spotting @Dr_Rezaee https://t.co/XNT7S8MPNr
2022-08-30 20:03:18 Pandemic mortality over the past 12 months, outliers, per capitaOnly Greece and Hong Kong fared worse than the United StatesJapan (even w/ BA.5 wave that has doubled cumulative deaths), UAE, Qatar are among the lowest fatality ratesvia @OurWorldInData https://t.co/U2gtBX8H98 https://t.co/hJJf9EpwGw
2022-08-30 18:35:47 The term "accessory genes mutations" is used to denote those outside of the spike"We interpret these data as suggesting that mutations outside of spike may be driving critical phenotypes of #SARSCoV2 infection and disease"Nice work by @mcgrath_marisa @MattFrieman and colleagues
2022-08-30 18:35:46 The spike-centric thinking of #SARSCoV2 does not take into account pathogenic mutations outside the spikeA report documenting potential importance of ORF3a/b and ORF8 in vivo, known to affect our innate immune response (IFN, 1st line of defense)https://t.co/d0xXiXGzBI@PNASNews https://t.co/X4f0MoftDp
2022-08-30 17:10:41 Good to see steady, albeit slow decline in US Covid hospitalizations, now less than 37,000But still nearly 3-fold that of April 2022's lowest point (metric definition hasn't changed) which should be attainable, at the leasthttps://t.co/7N96LQP0Dm https://t.co/im2u98ovUI
2022-08-30 13:53:42 On the after-effects of Covid, beyond and including #LongCovid"Covid generated a kind of epidemiological aftershock by leaving people susceptible to a huge range of other conditions"https://t.co/Tr9eFjnovw @FT by @SarahNev @federicacocco https://t.co/S2JNYobrhL
2022-08-28 15:39:31 This headline will not induce public confidence in the BA.5 boosters, with 175 million doses purchased https://t.co/v68wV79fVQIt may well turn out to be the right call, but there are many uncertainties, superimposed on poor US booster uptake, discussed https://t.co/BR54il19st https://t.co/rJvS1gYi69
2022-08-28 14:42:35 On the need for physician validation and empathy https://t.co/qIAunN252B
2022-08-28 14:42:33 The brain and #LongCovid https://t.co/kRS3MLXK5F a 5 summary by @WesElyMD Evidence/paths ->
2022-08-27 22:46:22 What's a variant-proof, universal vaccine?Our @scrippsresearch team put together a 2 minute video explainer https://t.co/hjfXoVj70G https://t.co/FNwI992VyP
2022-08-27 19:57:04 I reviewed the data herehttps://t.co/BR54il19st
2022-08-27 19:57:03 Why to make of the BA.5 boosters coming soon?The range of opinionshttps://t.co/9pXvgEs554 @LNeergaard @AP @Latimes @US_FDAhttps://t.co/QN03vrWJm4 @AliceParkNY @TIME @DrPaulOffit https://t.co/uNcejx0EFp
2022-08-27 18:40:41 Using RNA sequencing from tissue biopsy and #AI to discover, validate, and quantify Covid vascular inflammation (called C19-RS) from CT scans, linked with clotting and adverse prognosishttps://t.co/xJIaDGseKm @LancetDigitalH @escardio #esc2022 https://t.co/QL7Qf53KQ4
2022-08-27 18:23:20 If you're a man 65 to 74 years old, should you have cardiovascular screening including a CT scan calcium score, ankle-brachial index, AF, blood tests for LDL and diabetes?A large randomized trial with 5.6 year follow-up showed lack of benefithttps://t.co/HFMXfyeN8c @escardio https://t.co/2jOgxOLAnQ
2022-08-27 17:28:39 Relevant statements from the reports of these 2 trials https://t.co/fcZn7G56tx
2022-08-27 17:28:37 No.Ad in @NYTmag for a dietary supplement (Urolithin A) that costs $200/month and claims to be "clinically proven to renew mitochondria"2 small clinical trials cited, called ENERGIZE and ATLAS, conducted by the companyhttps://t.co/I10jupjXYQhttps://t.co/zzWJnGgAs8 https://t.co/8Hhmv33XBz
2022-08-27 16:30:19 Wrist sensors can help in early diagnosis of Covid/viral illness and may also be useful in managing #LongCovid, @TheLancet with @julialmv @ScrippsRTI and @RobertHirten @IcahnMountSinai https://t.co/KUhmHg3U28 https://t.co/MMIftkHcwo
2022-08-27 16:05:53 A bit of contrast https://t.co/TWWeKVLyxP
2022-08-26 19:35:38 @AstroKatie Agree, Katie. It's unpredictable. But I wouldn't have expected these findings in 20-year-old healthy soldiershttps://t.co/Z9WNhhNuJj
2022-08-26 19:19:47 While it isn't large, this is one of the most comprehensive #LongCovid prospective, w/controls studies yet. Not assessing mechanistic data (like immune response, persistent virus) but insights about enduring multi-system sequelae in a cohort that would be considered very low risk
2022-08-26 18:56:44 A prospective study of #LongCovid in young (median age=21), healthy, males (93%), with controls: "new evidence that even infections in young adults can lead to sequelae that persist several months"https://t.co/379fy4HmMW https://t.co/mp8METJrE6
2022-08-26 18:01:33 If you're into the impact of circadian rhythm and sleep on health, you'll find this new review @NatureRevGenet quite informative https://t.co/7avEroBCA4by @jlane_boston @SusanRedline and colleagues @BrighamWomens @broadinstitute https://t.co/4i560J0JPi
2022-08-26 16:26:25 This week's US genomic surveillance update BA.4.6 growth competing vs BA.5, slowly, most pronounced in one region (7)No other new variants at appreciable levelshttps://t.co/jjl2AnwOWX https://t.co/4O66l736Ld
2022-08-26 15:45:31 @SKDitta Much appreciated!
2022-08-26 15:29:49 Vaccines and boosters during the Omicron wave in Singapore, among >
2022-08-26 15:07:15 Consistent w/ the idea that "vaccine absolutism" (term from @SaskiaPopescu) won't cut itIn https://t.co/aGyvgFdoRO by @KatherineJWu
2022-08-26 15:02:22 "Most importantly, we need to achieve containment of the virus once and for all, and should not rely only on just the BA.5 booster." https://t.co/BR54il19st
2022-08-26 13:46:05 RT @Aiims1742: Nicely done! #OpenAccess in @NatureCancer:Cancer vaccines: the next immunotherapy frontierhttps://t.co/an3fahkaPE https://…
2022-08-26 06:05:31 How life expectancy in the United States "fell off a cliff"https://t.co/avXRtbg22T by @jburnmurdoch https://t.co/x6t4ZkSr8K
2022-08-25 22:55:16 "COVID-19 sequelae: can long-term effects be predicted?"No. That's the problem. #LongCovid cannot be predicted.https://t.co/eEy4EbtGqo @TheLancetInfDis
2022-08-25 21:52:49 RT @HandNF: "It’s actually striking that in 2 months from the June 28th FDA meeting, there is a BA.5 vaccine booster made at scale. That is…
2022-08-25 19:02:17 If you look at the spike mutation map for BA.5 and compare it to Alpha, the first major variant, it's striking how well vaccines have held up vs severe disease, and not surprising why it has been harder to suppress infections and spreadhttps://t.co/BR54il19st https://t.co/NMKx7mWadd
2022-08-25 17:45:57 The rate of asymptomatics for current infectious disease of interestPolio ~70%https://t.co/wCrxFSSscn.Covid ~30%https://t.co/SaD7D9WGS9Monkeypox ?% (cases documented)https://t.co/uQiXzPNGCN
2022-08-25 17:21:06 @katecrawford @AlondraNelson46 Yes, I wish it started right away instead of 2026
2022-08-25 16:21:52 Now replicated. Synthetic embryos in mice from embryonic stem cells https://t.co/dgJazenrWihttps://t.co/3o07C96ybIhttps://t.co/3wcakSd55B“The next milestone in this field very likely will be a synthetic stem-cell based human embryo”
2022-08-25 15:58:31 Gene therapies, the potentially curative "miracles of medicine," are hitting stride with 40-50 expected to be approved by 2030. But their up front costs remains a formidable challenge, despite favorable cost-benefit analyseshttps://t.co/tcT4bBLOaN https://t.co/p9GUXhQxen
2022-08-25 15:04:41 Important on #LongCovid —@BrookingsInst report on loss of ability to work and the financial tollhttps://t.co/VvFAlvpiNe by @kathrynsbach —"A whole new approach is needed"https://t.co/m6OEFrJkXs by @zeynep @nytopinion https://t.co/T4uyer0zqS
2022-08-25 14:50:50 Pre-bunking to fight against misinformation. Validation via 6 randomized trials using scalable videoshttps://t.co/B2cVrGHjHQ by @ScienceAdvances @roozenbot @Sander_vdLinden @_BGoldberg@steverathje2 @STWorghttps://t.co/cyMNJrik47 @nicoagrant @tiffkhsu https://t.co/TG6h3hX2IQ
2022-08-25 01:33:33 What we know and don't know about the BA.5 booster rolling out for all Americans age 12+ in ~2 weekshttps://t.co/BR54il19st https://t.co/5nF85lOnVq
2022-08-24 23:37:16 RT @PeterHotez: Pretty important thread from @EricTopol my take: despite the rebound, unpleasant minor side effects (metallic aftertaste+ s…
2022-08-24 22:53:39 Also published today, during the BA.2 wave in Hong Kong, among hospitalized patients without need for oxygen supplementation, early Paxlovid use associated with a 66% reduction of death compared with matched controlshttps://t.co/I8pG2RIFm8 and reduction ~50% with Molnupiravir https://t.co/3yimLea69Z
2022-08-24 22:32:50 @davidakin Thank you!
2022-08-24 22:24:58 @mdhhsu read the post to find out
2022-08-20 02:26:35 New CDC data on Covid deaths, age 50+, posted today, vs unvaccinated2 boosters: 94% reduction of death1 booster: 83% reduction of deathhttps://t.co/HGyjNwCm0vCurrent 2 boosters in USage 50-64: 11%age 65+: 26% https://t.co/L7OVsysrmB
2022-08-20 00:51:06 RT @SciImmunology: A new Editorial by @EricTopol and @VirusesImmunity calls for an accelerated initiative for nasal vaccination against #SA…
2022-08-19 20:04:12 This accompanied original research by @Jie_Immunology @ImmunologyTang @UVAImmunology colleagues https://t.co/kbV1dEJOK6Robust sterilizing respiratory tract immunity (BAL) from a nasal booster vaccine in the murine model, not seen with shots in people, including vs Omicron BA.1 https://t.co/n3kBAv8qh4
2022-08-19 19:23:52 "We urgently need to achieve population-wide respiratory mucosa immunity" to break the chain of transmission of Covid and achieve containment of the virusOur Operation Nasal Vaccine essay published @SciImmunology today https://t.co/OujfFxvdS6 an honor to work w/@VirusesImmunity https://t.co/eBHW3dRLMI
2022-08-19 18:09:55 @andkg @robsteinnews @NPR @NPRHealth @Nature @heidiledford Let me be clear. BA.5 ≠ influenza. It will be the 1st vaccine to go out at scale in the US since the original. There are no data for nAbs to BA.5 vax in humansWe don't even know if it will provide better clinical protection. There is no rush. Such data can be obtained in weeks.
2022-08-19 17:26:45 It was nice knowing you, US universal healthcare (light) for Covidhttps://t.co/UnCGPibWWU by @StephArmour1 https://t.co/NiCMWaaQVk
2022-08-19 17:13:36 Which &
2022-08-19 15:35:56 The skinny on non-nutritive sweeteners (they are not inert) via a randomized trial &
2022-08-19 14:41:35 What do high-demand cognitive work and chewing have in common? Energy sinks.Cognitionhttps://t.co/dFejfKmHwV @CurrentBiology Chewing https://t.co/zDIVuUnJtY@ScienceAdvances https://t.co/Kg96fdv4wg
2022-08-19 14:20:21 A new review of the T cell immune response from Covid infections, vaccines, and combined effect (hybrid) https://t.co/jWgo1smo3M @Anto_Berto @bertoletti_lab @ImmunityCP https://t.co/mG65sipeGt
2022-08-19 02:54:45 This isn't what "Living With Covid" was intended to mean https://t.co/Q1UV8aJrfF
2022-08-19 01:41:44 A high-resolution study of length of mild Covid infectiousness with virus culture and viral RNA load2/3rd of cases shedding virus, still infectious at 5 days post-symptom onset
2022-08-18 20:18:29 Fixed annotation, sorry https://t.co/KGA6ue9lxn
2022-08-18 20:16:21 US Covid hospitalizations are at a plateau ~40,000, which is ~4-fold where we were in April this year.Likewise, deaths are at ~500 each day, and confirmed cases still hover about 100,000 per day.This is not what containing the virus looks like. https://t.co/rh9ja8SKNK
2022-08-18 19:55:17 Full text here. One point I'm a bit at adds with:There has been some reduction of vaccine/booster protection from severe disease with variants, although it's still high (75-80%). Prior to Omicron and subvariants it was >
2022-08-18 19:06:34 RT @_Eric_Reinhart: My short piece this week builds on @EricTopol's 2019 essay in @NewYorker, and also what has been an unsurprisingly larg…
2022-08-18 18:01:25 A super summary on the pivotal role of T cell immunity in response to Covid vaccines @ScienceMagazine w/ @ScienceVisualsby @EJohnWherry and @BarouchLab https://t.co/GHng2HSEuL https://t.co/1CUt9KJUjl
2022-08-18 17:22:12 Only 30% of American children age 5 to 11 have thus far been vaccinated. A new @CDCMMWR of >
2022-08-18 15:41:26 Japan ranks 4th in the world for boosters, the US ranks 71st https://t.co/gWCbSb6EfDJapan's cumulative deaths per capita is 1/11th of the USYet BA.5, with its very high level of immune evasion, has challenged its immunity wallhttps://t.co/pQYFuqy954 https://t.co/NOLCYRykdI
2022-08-18 15:26:08 The ability to take on #SARSCoV2 variants can be greatly facilitated by improving nanoparticles A superb review @NatureNano https://t.co/34JnqDMZ8cBut it's science advances sitting in labs, not getting done at large to get ahead of the virus https://t.co/ZzQ8LFJ7eu
2022-08-18 15:10:45 @TRyanGregory @_TheAncientOne_ @OurWorldInData Japan's management of the pandemic has been exemplary
2022-08-18 14:25:08 Variants in Japan over time https://t.co/JzRj8Tkor8
2022-08-18 14:25:07 Japan's BA.5 wave deaths are now higher than any previous variant and still rising sharply @OurWorldInData https://t.co/2ZM3hEuN4t
2022-08-18 14:16:43 This would be a mistake"For the first time, the FDA is planning to base its decision about whether to authorize new boosters on studies involving mice instead of humans."https://t.co/T1NFucQdf7Public trust is essential before rolling out BA.5 boosters to millions of people
2022-08-18 00:46:53 The new study with longer follow-up of nearly 1.3 million people with Covid adds to the concerns and replication of these 2 brain imaging studies https://t.co/HJWtJWieWL
2022-08-17 22:56:08 Link for the editorial https://t.co/fnSZ6miI5AAnd quick summary @FT @clivecookson https://t.co/iNztfFpjjM https://t.co/BmVSUrWtBa
2022-08-17 22:35:09 Accompanying editorial @TheLancetPsych with good context @GlynLewis9 @drjprogers @ucl @UCLPsychiatry https://t.co/97NisoBsHq
2022-08-17 22:35:08 Main endpoint of increased risk and graphs showing timing over 2 years. Data from electronic health records, retrospective https://t.co/9bNlqJzUJo
2022-08-17 22:35:06 US data, lack of differences between variants (Alpha, Delta, Omicron) https://t.co/KmdPfaXj4h
2022-08-17 22:30:09 In 1.28 million people, up to 2 years after Covid, w/ matched controls: "The persisting increased risk of post-COVID cognitive deficit, dementia, psychotic disorders, and epilepsy or seizures" and "similar during the delta and omicron waves" #LongCovid https://t.co/FRyGDJ8pSd https://t.co/NuqJ5Fq0Kx
2022-08-17 21:13:10 Editorial: Stop using drugs that don't work.Ivermectin and Fluvoxamine and still widely prescribed.https://t.co/XfOPgSoyjE@ProfAbdoolKarim https://t.co/wEHoMpRVzv
2022-08-17 21:03:07 A randomized, placebo-controlled trial of 3 different drugs for Covid—metformin, ivermectin, or fluvoxamine—all of which failed to benefit with respect to primary endpoint, possible metformin benefit for a 2° endpointby @BramanteCarolyn and colleagueshttps://t.co/37zFMRvq8F https://t.co/ntmA0HBrvF
2022-08-17 19:59:22 Rapid waning of immune protection by BA.1/BA.2 infections (mostly breakthroughs) against BA.5 infectionshttps://t.co/9XTirVPDa2 15-day intervals (A->
2022-08-17 19:13:40 Give @CDCDirector for admitting "dramatic mistakes"https://t.co/zqvoJ1mkI1 the @FT coverage by @JamieSmythF with comments by @AmeshAAand me https://t.co/ESaAaWBbCP
2022-08-17 18:24:14 From yesterdayhttps://t.co/QNVmho3ikJ
2022-08-17 18:23:16 We went from sequence of #SARSCoV2 to highly effective vaccines in 10 months, which was unprecedented. But nearly 2 years later, we see no replication of such hyper-accelerated effort, despite remarkable advances in science Today @ScienceTM yet another https://t.co/aQCjw2Z30o https://t.co/BmbD7aDjWg
2022-08-17 17:21:31 How the amount of virus in infectees breathe changed as #SARSCoV2 evolvedhttps://t.co/dcNWs2Dtmchttps://t.co/opmUMvCgxd https://t.co/1UKBiPFNBx
2022-08-17 16:46:09 "The nightlife setting was the driver of Covid-19 spread, while household and healthcare settings were in the lower course of transmission chains"New report tracking Covid spread in Tokyohttps://t.co/kb9XFOGBKP https://t.co/HnxwVgcsbK
2022-08-17 16:13:29 @YouAreLobbyLud @CDCgov and now this.... https://t.co/rbW8X4RMlS
2022-08-17 15:49:16 We learned how to image cells without labelling, preempting disruption or killing, via deep learning #AI. Now the ability to sequence RNA of single cells without killing them https://t.co/cNyJcH987A another meaning to slice of life @BartDeplancke @EPFL_en @WanzeChen https://t.co/tX7Malx3EB
2022-08-17 02:56:18 Another step towards a pan-sarbecovirus, variant-proof vaccine. There are now >
2022-08-17 02:23:12 A brief #LongCovid thread well worth the read, on @jcouzin's @ScienceMagazine coverage/context of the new and insightful mechanistic report https://t.co/4bbg3VD5yV
2022-08-16 20:46:32 The denialist's Venn diagram https://t.co/5ih65iQwKo
2022-08-16 18:40:22 More perspective on the important new #LongCovid work by @sneakyvirus1 @VirusesImmunity @PutrinoLab and their colleagues @ScienceMagazine by @jcouzin https://t.co/vnVUVUpnIo“We should be trying these [potential treatments] right now” https://t.co/jhUL1OeHJf https://t.co/ZOj4RPqVkd
2022-08-16 17:25:33 Adding to the suboptimal T cell response in seniors, new data from @OHSUNews and @UTSWImmuno on how the neutralizing (and non-neutralizing) antibody response to vaccination diminishes with agehttps://t.co/rBEFjm5Qxd https://t.co/fxzKk1KHB3
2022-08-16 17:00:26 "Even a single case of paralytic polio represents a public health emergency in the United States."https://t.co/1Qavun6No3 new @CDCMMWR "95% vaccination coverage is required to provide herd immunity"https://t.co/pksC3nzU2E @FT @JamieSmythF @caitlinsgilbert https://t.co/d04pt3eEpk
2022-08-16 16:20:55 RT @YouAreLobbyLud: This is an excellent article by @EricTopol. It eviscerates the @CDCgov, and rightly so. I cannot understand what they a…
2022-08-16 15:05:13 The risk of blood clots in hospitalized patients with Covid vs influenza was increased 60-90% within 90 days, for venous but not arterial thrombosishttps://t.co/wPHf18NYYB @JAMA_currentRetrospective, much smaller influenza cohort from 2018-2019 https://t.co/sClYHF0J6U
2022-08-16 01:48:57 @ChristosArgyrop Thank you!
2022-08-16 00:48:16 New report on BA.2.75 today confirms less immune evasiveness compared with BA.5, and less cell-cell fusion than BA.5 https://t.co/u7hnNALX5a https://t.co/xgyPL5GRb7
2022-08-15 22:21:22 Bedside manner. From the patient perspective. Outstanding and inspiring, by Michelle Izmaylov @VUMChealth https://t.co/wnCrTpxh2B@AnnalsofIM https://t.co/MMgVx8OJbN
2022-08-15 22:02:48 RT @AnjKhem: "By steadfastly continuing to endorse this flawed CDC guidance, our public health agency has failed its namesake mission of co…
2022-08-15 18:16:56 Does multi-dose BCG vaccination help prevent Covid?A small randomized, placebo controlled trial in people with Type 1 diabetes https://t.co/iYUhzLnRyQ@CellRepMed https://t.co/fX0MXMvr1m
2022-08-15 17:15:42 RT @Kit_Yates_Maths: "The CDC position that we need to “live with Covid”, as espoused with its guidance, should be countered by exploiting…
2022-08-14 23:48:08 What I wrote about the @uk_biobank when it came out. The need for independent replication. That's what the new study provides.https://t.co/wySNMFcytY
2022-08-14 22:59:17 RT @Mike_Honey_: @EricTopol Thanks and I'm glad it was useful.Here's the full thread for more context - recent growth advantage is a heal…
2022-08-14 19:42:11 The formidable challenge of BA.5 doesn't detract from the outstanding containment of the virus and high adoption of vaccines in these countries, with a 6-11 fold reduction of cumulative mortality per capita compared with the United States@OurWorldInData https://t.co/00wQpIlJ3T
2022-08-14 19:00:11 For the multitude of people who think mild cases of Covid are totally meaningless, these results would beg to differ. Yes, it's a short-term effect so far and may be partially reversed over time. Yes, likely to be less w/ current variants and vaccination. But denial doesn't work.
2022-08-14 18:30:40 This week a new post-Covid brain MRI study was published, without baseline images and not as large as the best study to date by @uk_biobank I've compared them herehttps://t.co/SIWJuCDidR @PNASNews https://t.co/JF5UviTdYO @nature https://t.co/5zXZ0csnLV
2022-08-14 17:29:35 The rise of BA.2.75 has been studied very carefully by @TWenseleers and its trajectory may vary considerably between countries. Or we could see a co-dominance pattern, something that hasn't occurred yet /9 https://t.co/myYGLCDDGg
2022-08-14 17:29:33 More on BA.2.75Unlike BA.4.6, more evasive to BA.5 breakthrough infectionsGrowth advantage tied to enhanced ACE2 bindingBebtelovimab and Evusheld predicted to still be effective No sig increase in hospitalizations in India /8https://t.co/T8iIzUGTvZhttps://t.co/B7RGir61Hc
2022-08-14 17:29:32 What about BA.2.75?Spike: 9 amino acid residues differ from BA.2One report of less immune evasion than BA.5https://t.co/aSNpEAdW5KSimilar pathogenicity as BA.5 in expt'l model /7https://t.co/bFG1mrwYHi https://t.co/4ggttrP8cK
2022-08-14 17:29:31 What do we know about BA.4.6's properties?https://t.co/E4QrGwV6BZSpike mutation R346T may be keyIt appears to have more immune evasion than BA.5, some cross-immunity w/ BA.5 breakthrough infections, not resistant to Bebtelovimab, but Evusheld may not protect as well /6
2022-08-14 17:29:30 And to avoid spike-centric thinking, the mutation differences extend well beyond the spike, such as in the nucleocapsid (N), envelope (E), or ORF7b /5 https://t.co/Ma6PsxIFf8
2022-08-14 17:29:29 There are substantial differences in mutations for these 2 variants, spike map here, with context /4https://t.co/ExWF5Dsbhw https://t.co/7JERUyUkl6
2022-08-14 17:29:28 In the US, BA.4.6 has a foothold accounting for 5% of new cases https://t.co/jjl2AnwOWX, newly updated.BA.4.6 has been steadily growing here since JuneIt is already at 13% in US Region 7 /3 https://t.co/s5UndyXda2
2022-08-14 17:29:26 While BA.2.75 is becoming dominant in India, out-competing BA.5, we're now seeing signs it can also compete with BA.4.6 in Australia, as posted by @Mike_Honey_ /2 https://t.co/r1sRc2YjJm
2022-08-14 17:29:25 What variant will take over for BA.5 in the United States and why does it matter?It's currently between a BA.4/5 vs BA.2 subvariant https://t.co/V1UsNSU6m7
2022-08-14 16:49:04 @RenzPolster Yes, I made that point https://t.co/IEMD9R3LtU
2022-08-14 16:05:31 The @uscensusbureau data for #LongCovidSelf-reported, without controls, or pre-Covid baseline symptoms like the new Netherlands study (12% prevalence) https://t.co/nnZsWWa0jVBut, no matter how you look at it, it's affecting a substantial number of people https://t.co/10abaYrpJR
2022-08-14 14:20:10 RT @CrabbBrendan: Thanks again for this excellent summary @EricTopol. And while we search for 'cures', I can't stress enough your final con…
2022-08-13 16:25:04 @paulg The protective power of massive prior infection exposure (hitting majority of their populations) which also adds to vaccine protection with hybrid immunity (vs the whole virus plus enhanced vs spike).Explained in full herehttps://t.co/pQYFuqy954
2022-08-13 16:20:36 Previously it was @GeisingerHealth and @Regeneron. Now it's @MountSinaiNYC and @Regeneron. Large health systems with their electronic health data and genomic sequencing for potential of drug discovery, but also bioethical considerationshttps://t.co/0rScAFfaYc by @JoeKGoldstein https://t.co/wLkD7A9yie
2022-08-13 15:28:39 @calirunnerdoc Yes, evidence from multiple reportshttps://t.co/tatxeNskY9
2022-08-13 15:18:39 Many other countries, like the US, had major case surges uncoupled from deaths as a function of their immunity walls, particularly related to prior infections. Discussed here https://t.co/pQYFuqy954
2022-08-13 15:18:38 The BA.5 wave resulted in higher deaths than from any prior variant in Australia, New Zealand and soon to be the case in Japan. That's despite very high vaccination and booster rates, attributable to BA.5's extreme biologic properties of immune escape and transmissibility https://t.co/z9TxC6shTR
2022-08-13 15:01:50 In one week's time we learned more about #LongCovid that we had in months, including evidence for a potential biomarker. Yet we're still way behind where we need to be to help millions of people who are affected. https://t.co/IEMD9R3LtU https://t.co/ONWeuShJ1o
2022-08-13 14:25:58 Thread referred to by @holmescnn https://t.co/dKNsWXpM0b
2022-08-13 14:25:57 Last evening, we discussed the new @CDCgov guidelines, purportedly a shift to "protect the vulnerable," but fail to do so on many counts https://t.co/lJeFXASFjs
2022-08-12 17:34:36 RT @Karl_Lauterbach: Hier noch einmal eine gute Übersicht der Studien, die ab 50 einen klaren Überlebensvorteil der 4. Impfung zeigen. Die…
2022-08-12 16:58:36 RT @profhelenward: Excellent summary of evidence from recent Long Covid studies. Suggests clusters, and possible mechanisms for some.Also…
2022-08-12 15:57:50 @manda_trkac @ImmunityCP @kieluni Agree! Not petty at all.
2022-08-12 15:47:43 @ImmunityCP On T cell response to vaccination in seniors"Our results reveal that an intrinsic defect of the CD4+ T cell repertoire causes the age-dependent decline of immune response quality against SARS-CoV-2"https://t.co/ensXlddJ3T @kieluni https://t.co/VnCZf2RkTn
2022-08-12 15:38:56 For context"The increase in maternal death during delivery hospitalization and pregnancy-related complications during the pandemic is alarming."@JAMANetworkOpen todayhttps://t.co/TOvbaiWeSB by @Rose_L_Molina @BIDMC_ObGyn @HarvardChanSPH @joefigs2 @harvardmed https://t.co/zpCCNfdTwR
2022-08-12 14:42:20 RT @pranavrajpurkar: Delighted to share our review on "Self-supervised learning in medicine and healthcare" in Nature Biomedical Engineerin…
2022-08-12 13:34:58 The US booster botch for even 3rd shots. All @OECD countries except US >
2022-08-12 13:34:57 Summary of data supporting survival benefit of a 4th shothttps://t.co/lMLDEgpQvL
2022-08-12 12:54:05 RT @sheencr: Really excellent summary from @EricTopol on #LongCovid latest data incl markers to identify patients (a role for cortisol) a…
2022-08-12 04:34:31 RT @uche_blackstock: The CDC is relaxing COVID guidelines and saying it’s because we have a high percentage of population immunity when onl…
2022-08-12 01:06:10 In the past week, there's been a flurry of new, informative reports on #LongCovid. I've tried to summarize them here along with the implicationshttps://t.co/IEMD9R3LtU (PS you can subscribe, it's free)
2022-08-12 00:11:21 This seems importantClassified documents relating to nuclear weapons were among the items FBI agents sought in a search of former president Donald Trump’s Florida residence ohttps://t.co/tclYL3Nbyh
2022-08-11 23:06:01 Marked reassurance for safety of Covid vaccines and reduction of significant health events in pregnancy with an unvaccinated pregnant control grouphttps://t.co/rHhkzKO1BA @TheLancetInfDis https://t.co/jEOyjRvUlq https://t.co/ZqBnREl5sa
2022-08-11 20:06:25 RT @EricTopol: Covid and the brainhttps://t.co/SIWJuCDidRJust published @PNASNews —cortical atrophy and cognitive dysfunction in 81 peop…
2022-08-11 19:40:09 Covid and the brainhttps://t.co/SIWJuCDidRJust published @PNASNews —cortical atrophy and cognitive dysfunction in 81 people with mild Covid vs matched controls (as seen in @uk_biobank study)—astrocyte infection in severe Covid, recapitulated by iPSCs https://t.co/p8Id5nzbO3
2022-08-11 19:26:49 Our CDC at work. This is embarrassing, to say the least. https://t.co/21IFipxDNl
2022-08-11 19:17:30 The 4th shot in Americans age 50+ 10% age 50-6425% age 65+The US now ranks 80th in the world for booster vaccines at 32% of populationhttps://t.co/gWCbSb6EfD https://t.co/SOtBwq1zCZ
2022-08-11 19:13:21 My concerns a month ago, unaddressedhttps://t.co/AzO91kFuMQ
2022-08-11 19:06:14 https://t.co/RrJM060RXw is the link
2022-08-11 19:06:13 The @CDCgov doubles down on its flawed, not evidence based Covid recommendations with a new guidance document1. Leaves fully vaccinated = 2 shots, stay "up to date"2. Leaves isolation at 5 days w/o rapid tests3. Pushes "community levels" when real info is "transmission levels" https://t.co/Sflm8U0xbS
2022-08-11 17:13:50 The positivity rate of self rapid antigen tests tracked well with PCR throughout the United States Omicron and subvariant waves https://t.co/zNZYmyHZf6 https://t.co/cOzT3bbDpc
2022-08-11 17:04:35 CAPTCHA 2.0 :-)by @speedbumpcomic https://t.co/2DYo2YIG3g
2022-08-11 16:31:59 We've learned a lot this year about the underpinning of Epstein Barr virus in multiple sclerosis. The gut #microbiome is also important, as delineated in this excellent review https://t.co/11ly64ojsR @NatRevNeurol https://t.co/OLae2MFyeJ
2022-08-11 16:10:51 Persistent circulating spike protein in #LongCovid (PASC)https://t.co/R7QmEFaeMSAdds to finding of antibodies to #SARSCoV2 nucleocapsid (N) in unvaccinated people with Long Covidhttps://t.co/jFbxvhdOWP https://t.co/OZdrDPEb3y
2022-08-11 15:06:38 Until now, most #AI in medicine has involved large annotated datasets for inputs, known as supervised deep learning. Next up is self-supervised learning. @RayanKrishnan @pranavrajpurkar and I review this topic @natBME https://t.co/5Uyrc8rX4m https://t.co/81EhU0StVi
2022-08-11 02:00:53 There have now been >
2022-08-11 00:58:25 @_TheAncientOne_ @ewencallaway @Nature @yunlong_cao Yes, it would be good to hear from Yunlong on this contradiction
2022-08-11 00:37:18 What about BA.2.75?“I think people who have had BA.5 will not have a breakthrough infections with BA.2.75, and vice versa.”https://t.co/T8iIzUpi7p by @ewencallaway @nature w/ @yunlong_caoand https://t.co/2dFHUOIv2T https://t.co/iqwpQvneFk
2022-08-10 23:53:08 BA.4.6 is currently the only other variant in the US besides BA.5 that has appreciable growth, at ~5% of cases, w/ its R346T mutation. A new study suggests:—Cross-immunity w/ BA.5 breakthrough infections—Bebtelovimab still potent, but Evusheld escapehttps://t.co/E4QrGwV6BZ https://t.co/nJ2SofgG5b
2022-08-10 19:25:26 The low cortisol levels and ACTH in the #LongCovid group is especially intriguing, supports a dysfunctional hypothalamic-pituitary-adrenal axis, not so simple for steroid Rx. May help explain some symptoms and serve as a potential biomarker https://t.co/tT1wPBKZ9q
2022-08-10 18:18:10 My colleagues @scrippsresearch just published exciting work discovering broad neutralizing antibodies from macaques (with their structural biology) that could be used as a template for variant-proof Covid vaccineshttps://t.co/lbTuGRzWvh @andrabi_raiees @DennisRBurton @menz45 https://t.co/2rDWrAiYQ5
2022-08-10 17:30:57 Correction, typo: its striking BA.2 wave
2022-08-10 17:26:43 South Korea's BA.5 wave. Currently highest cases per capita in the world. Much less impact than (and an outgrowth from) its striking BA.1 wave.@OurWorldInData https://t.co/ui1mrfJr4c
2022-08-10 16:56:14 An extraordinary high-resolution map of the heart after myocardial infarction, with spatially integrated single-cell gene expression and epigenomics https://t.co/P1L6bTDUdI@Nature @rkramann @KuppeChristoph @saezlab https://t.co/b9WIJtihd8
2022-08-10 15:46:32 And here's the explainerby @VirusesImmunity https://t.co/9TMcyKrGXV
2022-08-10 15:42:45 New insights on the underpinnings and biomarkers for #LongCovid (LC) in a systematic study https://t.co/jFbxvhdOWP*Uniformly low cortisol level*, along w/antibody and T cell findings @VirusesImmunity @PutrinoLab HC-healthy controls, CC-convalesced w/o LC https://t.co/3IN7RckkdE
2022-08-10 15:11:41 @K_G_Andersen @NatRevImmunol @rahulsurya85 @TheOttLab Yes, I see your point for how the table is over-simplified and can be misleading. Their point on susceptibility to *infection* as a function of variant (not severe disease, yet not specified in the text) has some merit, consistent with what is being seen clinically
2022-08-10 14:59:00 How does Covid heighten the risk of clotting?https://t.co/WT96lC9dyB@NatRevImmunol @emconway99 @JHMorrissey https://t.co/DkXwSpUbRB
2022-08-10 14:45:55 If you thought we've seen the end of major #SARSCoV2 variants, think again https://t.co/DkiguWbGJ9
2022-08-10 14:29:54 The enhanced protection afforded by hybrid immunity (Covid infection plus vaccination) is influenced by variants https://t.co/ocjVAUDpZF @NatRevImmunol @rahulsurya85 @TheOttLab https://t.co/X7d4L6wAS8
2022-08-10 00:57:34 End of paper:"Consistent w/ this perspective, 70 investigators signed a letter to the FDA on April 21, 2022 encouraging the inclusion of T cell responses in addition to antibody titers for the evaluation of SARS-CoV-2 vaccines in humans"Letter (I signed)https://t.co/cvgOcvas96 https://t.co/r1vB5joQjE
2022-08-10 00:51:36 And what happens if you deplete CD8+ (cytotoxic) T cells with a monoclonal antibody after vaccination + #SARSCoV2 infection?https://t.co/7wjpI8rILe @SciImmunology (macaque model) https://t.co/glworgmhVU
2022-08-09 22:22:37 Why are people age 50+ at higher risk of severe Covid?A new @PNASNews study indicates their significant narrowing of T cell diversity in response to infections may be part of the explanationhttps://t.co/vamn6sp8ug https://t.co/kbtIfnMv0Y
2022-08-09 20:46:51 @calirunnerdoc @Nature @heidiledford I agree with this concern. Most, if not all, of the trials are small
2022-08-09 19:55:13 Important to emphasize this is a potential that has not been actualized clinically.But all the more reason to be prepared, accelerate efforts to have backup and combination oral anti-virals
2022-08-09 19:51:31 @JuliaRaifman For current virus, likely yesFor Mpro resistant mutations (*if* they become prevalent), hard to know
2022-08-09 19:35:40 More signs that Paxlovid resistance may be on the horizonhttps://t.co/ARkSE5akdRhttps://t.co/2BFZ9NWS1t https://t.co/nNDetN8bot
2022-08-09 19:08:08 @nlj @OurWorldInData No question! US has >
2022-08-09 17:53:48 Recognition for the 1st open-source Covid vaccine phenomenal contribution by @mebottazzi and @PeterHotez @FastCompany by @adambluestein https://t.co/V21apBgAvf https://t.co/n6AujxMikQ
2022-07-26 23:53:38 RT @EricTopol: A new BA.5 variant report from Portugal indicates higher rate of hospitalization (>
2022-07-26 19:47:48 BA.5 in AustraliaNew record of hospitalizations @covidbaseau Sharp rise in deaths @OurWorldInData https://t.co/PQYcZtmSOl
2022-07-26 18:58:08 RT @bhrenton: As today's White House summit starts in the next hour, a pertinent commentary by @EricTopol and @VirusesImmunity, who propose…
2022-07-26 17:32:30 The length of time of infectiousness of #SARSCoV2 https://t.co/IB2yW3wMjT"There is no data to support 5 days or anything shorter than ten days [of isolation]."Paxlovid rebound may extend that further
2022-07-26 16:11:16 The BA.5 variant now accounts for 82% of new cases in the United Stateshttps://t.co/jjl2AnwOWX https://t.co/8M1MtXtXyu
2022-07-26 15:57:11 "Hundreds of thousands of [Evusheld] doses sit on shelves in hospitals and infusion centers across the country" while the vast majority of 7 million immunocompromised Americans who would benefit are not getting this prevention https://t.co/LhL4WofyFF
2022-07-26 15:07:31 New @ScienceMagazine on the science of the origin of #SARSCoV2 https://t.co/FH7eNfRfHshttps://t.co/YLTRcFx7fX https://t.co/2y8krUeoY0
2022-07-26 14:51:40 But despite this and demonstrated efficacy &
2022-07-26 14:51:39 Just out @ScienceTM The robust antibody immune response that an mRNA vaccine induces in children, including "highly preserved omicron-specific functional immunity"https://t.co/Qsa0fxdhwv @ragoninstitute https://t.co/n5iExIZlla
2022-07-26 14:30:00 The body of evidence for the protective benefit of masks, updated with multiple new studies, for community and health care settingshttps://t.co/1hsoxKYaNX @AnnalsofIM https://t.co/m6QWBWVbrp
2022-07-26 14:02:01 @backagainmaybe @mehdirhasan the graph was for Japan, and deaths are on the rise there https://t.co/Fa2nKoDykY
2022-07-26 13:48:42 The absolute rates of hospitalization are low, due to the immunity walls built in Portugal and Denmark (from vaccines, boosters, infections), but the increase with BA.5 reflects its higher virulence/pathogenicity
2022-07-26 13:19:39 No sign of BA.5 wave let up here https://t.co/3qdpIeF2Je
2022-07-26 05:14:01 A new BA.5 variant report from Portugal indicates higher rate of hospitalization (>
2022-07-26 02:56:45 No. https://t.co/l3bE5AIgNM @CellRepMed https://t.co/PPkROpI2ON
2022-07-26 00:44:26 RT @EdwardTufte: Brilliant and credible reporting of current situation. To reason about a pandemic requires pandemic data, a longer time…
2022-07-25 22:19:25 Here's the agenda for tomorrow's WH meeting on future of Covid vaccines. You can register here: https://t.co/1o8JKN1FdW I was asked to join the 2nd panel, but unable to make it. Great that @VirusesImmunity will be there. Let's gets nasal &
2022-07-25 21:15:11 if you don't have time to read the above @statnews piece, here's the gist https://t.co/kWrYthpweS
2022-07-25 21:11:17 https://t.co/tk7xwvLO8Phttps://t.co/tk7xwvLO8P
2022-07-22 15:19:04 Some reassuring new data for #LongCovid in kidshttps://t.co/6M7eDe0CaP Only "slightly higher" than the rates vs matched children without Covid, more seen in hospitalized and older kids @JAMANetworkOpen https://t.co/zZYQCjXHME
2022-07-22 14:26:26 Very good to see that the rare and potentially fatal Covid MIS-C in children (multi-system inflammatory syndrome) has markedly declined with Omicron, 95% less than Alpha https://t.co/6TcTFwBybn @deniseroland https://t.co/J9nSV55UGV
2022-07-22 14:16:24 Where the spread of the BA.5 variant has outpaced the prior BA.1 wave with nearly 200,000 cases yesterday https://t.co/bSW4QCF9Gp
2022-07-22 14:00:39 RT @ddiamond: White House has vowed to go “above and beyond” CDC guidance to care for Biden.“The fact they are overriding CDC recommendat…
2022-07-22 13:53:07 The prognosis is good, may take longer to fully resolve with BA.5. I also spoke to Kim about debunking the notion that vaccines "are not working." Yes, they're leaking re: infections, but they've already saved >
2022-07-22 13:06:05 RT @IforRWilliams: A clarion call from @EricTopol @VirusesImmunity in a new editorial:"As the virus continues its accelerated ability to e…
2022-07-22 04:39:10 @ShanLuLiu1 @SciImmunology @VirusesImmunity Such an important study and contribution from you and your colleagues. Back to you—thanks!
2022-07-22 02:51:18 RT @VirusesImmunity: I am thrilled to coauthor an editorial piece for @SciImmunology with @EricTopol highlighting the need for Operation Na…
2022-07-21 22:22:53 @TWenseleers After a few weeks looking at 2.75, your post was the first one I saw for any place outside India w/ growth advantage over BA.5 (despite detection in so many countries). There are mixed data out on its immune evasion. Agree it needs to be watched
2022-07-21 21:37:45 Here's the list of the 12 nasal vaccines in clinical trialshttps://t.co/xbbjwc4Ln7 @TheScientistLLC https://t.co/LJzN3S3vyT
2022-07-21 21:27:35 @TWenseleers Appreciate your points, Tom, w/ BA.2.75 data from countries w/ a BA.5 bkgd. My point on "scariants" (a word I coined) is that we needn't get carried away until we have clearcut + data, since so many have turned out to be false alarmsOthers feel similarlyhttps://t.co/yZgM8Bfk9Y
2022-07-21 20:02:47 RT @SciImmunology: “The prospect of achieving [containment of #SARSCoV2] with nasal vaccines is high, but will only be possible with dedica…
2022-07-21 19:03:53 We fully recognize the challenge of a successful nasal vaccine for high efficacy &
2022-07-21 18:57:42 That's "lightning speed" not lightened.There are now 12 nasal vaccines in clinical trials and 4 are far along, in Phase 3.But no plans for manufacturing at scale, distribution, accelerating. No government support. Yet a major unmet need
2022-07-21 18:27:50 It accompanies an elegant study in people &
2022-07-21 18:27:49 In today's @SciImmunology, @VirusesImmunity and I call for Operation Nasal Vaccine, the urgent need for a lightened speed initiative, to help block Covid infections and transmissionhttps://t.co/OujfFxMgU6 https://t.co/a6bXX7sy01
2022-07-21 17:09:36 But the 65% increased risk of hospitalization for BA.5 is a source for significant concern, if replicated would point to higher pathogenicity and virulence for this variant
2022-07-21 17:01:39 "No evidence of decreased vaccine effectiveness against BA.5 compared to BA.2" (With most extensive genome sequencing to date to help differentiate variant effects)
2022-07-18 14:59:10 BA.5 in Greece https://t.co/5Rrdcwfdbx
2022-07-18 14:07:26 Novavax vaccine with booster induced neutralization antibodies vs BA.1 and BA.4/5 as well as 3 mRNA shotshttps://t.co/p3Pkeh30UT https://t.co/uYQp9fyOpu
2022-07-18 13:54:27 Not "Living with Covid" by the @bmj_latest Editorshttps://t.co/PettYwCGzk"How is the government responding to this crisis? Largely by pretending it is not happening or implying it is all under control."Seems familiar here https://t.co/89PKIs6UWw
2022-07-18 13:46:41 @matthewherper Thanks Matt. It was always a fishy story, too good to be true
2022-07-18 13:31:32 Our covid times :-)by PC Vey @NewYorker https://t.co/bgWZQUBxkn
2022-07-18 00:15:36 Epstein-Barr virus is the leading cause of multiple sclerosishttps://t.co/Q7aEwL45ZwSummary of one of the most important advances in life science this year @ScienceMagazine https://t.co/2tUgZrfxye https://t.co/8FjgOstXsu
2022-07-17 21:37:21 "But last week we got a reminder of other kinds of facts, the kind that bring us awe and comfort and context — even joy. The kinds of facts that prompt scientists to break down in tears."https://t.co/LYg2cwKQXh+ @sdutBreen :-) https://t.co/nl6N0BA9Ln
2022-07-17 19:28:23 @uhoelzle Yes, I do think more infections in the unvaccinated reference group is playing a role, reducing the VE gradient. But they're also frequent in vaccinated, which should bolster immunity. Paxlovid is now heavily being used, adding another confounding factor for hospital admits
2022-07-17 19:18:55 OTOH, hospital admissions are up more sharply in many countries that provide their data, overall well below BA.1 levels, for the same reason https://t.co/BNfkHN95PU
2022-07-17 18:57:29 The world and the BA.5 wave—2nd highest in confirmed cases after Omicron BA.1 with substantially less reported—Uptick in deaths, fortunately much lower than BA.1, due to population immunity wall of vaccines, boosters and infections@OurWorldInData https://t.co/2i8uYgRcjU
2022-07-17 15:14:46 Boosters are essential to provide protection, but that may be slipping as the virus continues to evolve.Not encouraging.From >
2022-07-17 01:16:22 RT @debra_caplan: After successfully avoiding Covid for 2.5 years, my husband tested positive for Covid 3 weeks ago, cleared the infection,…
2022-07-16 21:17:55 @UrnovFyodor Thanks. Hope for a rapid and full recovery, Fyodor
2022-07-16 20:45:06 And herehttps://t.co/wpFmCmul30
2022-07-16 20:15:49 @anonymous1967x Agree!
2022-07-16 20:07:59 So many candidates, yet so little attention https://t.co/xbbjwc4Ln7 @TheScientistLLC by @JefAkst https://t.co/7bWAKxrlHl
2022-07-16 19:54:42 I recently wrote more about this and what can be donehttps://t.co/vwK1ZXsU7mhttps://t.co/ibgdJ7yYlI https://t.co/eXLGIFtyUT
2022-07-16 19:50:46 @SmoMichelle @StudBigg That's why I tried to simplify itHere is the Figure and the legend, p. 34And I previously wrote at length about this topichttps://t.co/vwK1ZXsU7m https://t.co/Ak879dwgoE
2022-07-16 19:40:24 @StudBigg there's a link if you are not too lazy to look at it and answer your question
2022-07-16 19:31:25 As the variant antigens drift further away from the ancestral #SARSCoV2, with more immune escape, growth advantage and fitness of the virus, the people drift off to sleep rather than taking initiativeAntigenic map adapted from https://t.co/VBDwVFH3Su https://t.co/0zo0AE8zwl
2022-07-15 23:26:28 Do the added mutations in BA.2.75 confer a different immune evasive pattern cf BA.5?Yes, at least that appears to be the case for Bebtelovimab, which has still shown efficacy for BA.5Other differences noted.https://t.co/Wf6uHNbGIW Mutation map at right by @PeacockFlu https://t.co/BTdGuT1B3v
2022-07-15 19:54:45 Acknowledging that the unvaccinated reference group is much more apt over time to include people w/ Covid infections. But so are the vaccinated, w/ hybrid immunity. IMO, there are multiple signs of VE attrition in this data set, particularly for BA.2 variants. No BA.5 data yet
2022-07-15 18:12:02 Recall that through the Delta variant w/ a 3rd shot booster, vaccine effectiveness vs hospitalizations was maintained ~95%
2022-07-15 17:46:40 This is quite telling about the slippage of protection of vaccines vs hospitalizations. With BA.2/BA.2.12.1 and 3 shots, in age 50+, vaccine effectiveness was only 55%.Restored to 80% w/ 4th shot Too much happy talk about vaccines providing great protection from severe disease https://t.co/5wOtxQU9Zf
2022-07-15 17:42:58 New CDC @CDCMMWR on Omicron variants (BA.1, BA.2, BA.2.12.1) Importance of booster to restore vaccine effectiveness improved after significant drop-off (Table), BA.2/BA.2.12.1 variants worse declineBenefit3rd shot all ages 18+4th shot age 50+https://t.co/nlB0B7A9R1 https://t.co/LDP1Lus6Uz
2022-07-15 16:55:10 New: 2nd booster/4th shot broadening in the UK"people aged above 50, along w/ residents &
2022-07-15 16:36:59 RT @PeterHotez: At the risk of sounding like a broken record: maximize your boosters. Get your 2nd booster (4th immunization) if you are el…
2022-07-15 14:34:45 Misleading: Detection ≠ Spreadhttps://t.co/ryd3Wyv6IK https://t.co/ywXKA2ylep
2022-07-15 14:28:04 US Covid hospitalizations crossed 40,000 for first time since the end of February and slope of their ascent is increasinghttps://t.co/QPRo6jaOka https://t.co/oYIST9PYeL
2022-07-15 14:19:54 RT @EricTopol: Yet another study of improved survival with 4th dose of vaccine compared with 3rd, nationwide Sweden, here for age 80+https…
2022-07-15 02:03:28 With #COVIDisAirborne, the factors that modulate the duration of aerosol infectivityhttps://t.co/Bc9Iwx4uV0 @PNASNews @JakobLondahleditorial to https://t.co/DLhZvenOvj https://t.co/s5DdBWTZhL
2022-07-14 23:44:14 Reduction of death for age 50+, 4th vs 3rdhttps://t.co/HGyjNwCm0v https://t.co/dntiKA57IH
2022-07-14 23:44:12 Here for improved survival, 4th vs 3rd shot, age 60+https://t.co/tcGQ0D9aM9 https://t.co/SYLM0XjqK1
2022-07-14 23:21:35 Yet another study of improved survival with 4th dose of vaccine compared with 3rd, nationwide Sweden, here for age 80+https://t.co/tWMhxQdYxn https://t.co/jSKBxtK7Hi
2022-07-14 21:12:31 Nice summary of this report @Nature https://t.co/5kiusZ6XB5 by @meprillaman w/ @profshanecrotty https://t.co/OxlHpp5kTJ
2022-07-14 19:13:57 Very good explainer on imprinting @FT to complement the new publicationhttps://t.co/5MmqWrLmFC
2022-07-14 19:13:56 The #SARSCoV2 infection imprinting problemhttps://t.co/PE4QjMv69Unew @ScienceMagazine by @BoytonRosemary @Daltmann10 @imperialcollege and colleagues https://t.co/fZYaTcWYv2
2022-07-14 17:37:04 @saahilmenghani Hard to give strong recommendations without specific immunologic data but, in general, mixing (not matching) an adenovirus-vector or whole virus with an mRNA or protein--primary series/booster or vice versa--would be expected to induce broadest immune response
2022-07-14 17:14:52 @ScottGottliebMD Important qualifier. Thanks for noting
2022-07-14 17:11:46 Reassuring.There are no signs of spread of BA.2.75 ("Centaurus") in any other country besides India, a place with minimal BA.5 https://t.co/bQuxSTGGa9
2022-07-14 01:27:03 Full @pbsnewshour segment on the BA.5 variant, Paxlovid, action steps, with transcripthttps://t.co/grWLMlK8lK w/ @WmBrangham and @JudyWoodruff
2022-07-14 01:05:22 Latest review of incidence and natural history of myocarditis/pericarditis following Covid vaccination with 46 studies, >
2022-07-13 23:26:01 RT @NewsHour: The new BA.5 coronavirus variant is fueling yet another wave of COVID-19 infections. The CDC said it's now the dominant strai…
2022-07-13 22:11:52 Good https://t.co/zimKAarr8Z
2022-07-13 22:01:16 Ladder diagram of variant growth advantage, shown at yesterday's @WHCOVIDResponse BA.5 press briefing https://t.co/W2pfbrI3ys by Tony Fauci https://t.co/e0TVBnbPJF
2022-07-13 21:52:30 RT @AliHMokdad: Agree with @EricTopol “They haven’t gotten across that two shots is totally inadequate,” they are not doing enough and not…
2022-07-13 21:10:00 2 @NEJM reports on acute hepatitis in children raising the question as to whether adenovirus 41 is involved—still not resolvedhttps://t.co/Lwq8gjPEd7https://t.co/BOdLOaUVQB https://t.co/KJNeSmbdo0
2022-07-13 19:21:34 US Covid status: difficult to track, but this is what we've got:Hospitalizations about to cross 40,000 todayhttps://t.co/QPRo6jaOkaAll metrics are uphttps://t.co/OYKQV2K7hr https://t.co/uVwcvMkZZQ
2022-07-13 18:29:00 A step towards a universal flu vaccine https://t.co/Dgb7cPg6YP @ScienceTM A more formidable challenge than one (variant-proof) to #SARSCoV2 as we reviewed @nature here https://t.co/eKHGg7EPtM https://t.co/ZNtft5C9M3
2022-07-13 16:03:48 How #SARSCoV2 infects/affects brain astrocyteshttps://t.co/bXKLN6GzCg @PNASNews by @Andrews_MG @tmturkee @TheOttolab @Kriegsteinlab and colleagues https://t.co/Tlk4PNMHp6
2022-07-13 15:16:59 @NateSilver538 @OurWorldInData New Zealand is a model country for how it managed the pandemic, including a high vaccination &
2022-07-13 15:03:52 @NateSilver538 @OurWorldInData Yes, that hasn't changed throughout the pandemic. The signal from small population countries can be difficult to interpret, but longitudinal assessment helps. As does global contexthttps://t.co/dDpgqd3vpf https://t.co/XOMiVDzCBO
2022-07-13 14:55:53 BA.5 in New ZealandNote deaths vs Omicron BA.1 wave@OurWorldInData https://t.co/MilkXb3MtD
2022-07-13 01:42:51 This is better than what might have been predicted with the relatively narrow observed immune response from BA.1., BA.2. Bodes well for some added protection vs BA.5 from a BA.1 booster
2022-07-13 01:39:59 @kallmemeg Yes, certainly, Meaghan. it's the known "boost (bird) in the arm (hand)" benefit now vs. some unknowns in the months ahead. No right answer, but the way BA.5 is erupting here would think to. take the up-front protective benefit for those at increased risk
2022-07-13 01:01:57 New study from Qatar on BA.4/5 reinfection—Protection of a previous infection against BA.4/BA.5 was lower than that against BA.1/BA.2 (>
2022-07-13 00:47:20 @ejwillingham and also seen with Delta, as they demonstrated. Thanks
2022-07-12 23:48:26 Another undesirable feature of the BA.5 variant: Enhanced antagonism of innate immunity not seen in prior Omicron variants (BA.1, BA.2) https://t.co/6AfXx0RuBO https://t.co/nQ9e9vs6fa
2022-07-12 22:15:23 Thinking about the overlap of Americans who are still Covid cautious and those paying close attention to the Jan 6th hearings...... and those ignoring both
2022-07-12 21:11:49 https://t.co/WPD4HOwHTo
2022-07-12 21:11:48 The US pandemic mortality gap vs Canadahttps://t.co/mkc4PuljI3 by @DFisman @PNASNews "How many lives could have been spared, had it emulated some of its global peers"Editorial accompanying paper by @Alison_Galvani and colleagues in connected post below https://t.co/OFIIN06A96
2022-07-12 18:37:08 For now https://t.co/Uomri7gwwX
2022-07-12 17:40:00 @Ddrekonja Agree on that. Thanks
2022-07-12 16:55:36 Would add hybrid immunity to the boost later column (i.e. 3 shots and a prior infection). Note this refers to a 4th shot, with a person beyond 4-6 months from 1st booster
2022-07-12 16:52:14 I'm getting a lot of "To boost or not to boost" questions, so here's a Table with some recommendations now that boosters will soon be available to all adults. There are many uncertainties for waiting, and the original vaccine boost provides an extra layer of protection. https://t.co/FWq0m8p4g4
2022-07-12 16:16:10 BA.5 is now >
2022-07-12 15:40:20 @NightShiftMD Many thanks, Brian
2022-07-12 15:33:07 What happens if we don't take much more aggressive steps now towards nasal spray and variant-proof vaccines when an even worse #SARSCoV2 immune evasive variant shows up in the months ahead?
2022-07-12 15:21:12 Just published @ScienceMagazine are 2 more broad neutralizing antibodies with "unprecedented breadth" that add to a long list of well-suited candidates/basis for a universal pan-β-coronavirus vaccine https://t.co/VP75TyBMN7https://t.co/ZFT0pmYZXN https://t.co/VzCk5aELhY
2022-07-12 14:47:20 Today @CDCgov finally warned about BA.5Can you please fix the other issues on this punch list? https://t.co/AzO91kFuMQ
2022-07-12 14:35:39 @Laurie_Garrett @uche_blackstock @WhiteHouse Finally, the wake-up call ⏰
2022-07-12 14:17:31 @CarlosdelRio7 @latimes Thanks Carlos
2022-07-12 13:54:29 @CarlosdelRio7 @CDCgov The CDC is a major reason why this occurredA year after boosters were validated to save lives, the CDC still says "fully vaccinated"= 2 shotsAnd https://t.co/Amgvw8BEGw
2022-07-11 17:49:08 People keep writing "it's just a cold now." Wrong. https://t.co/HwRh6GlKd7
2022-07-11 17:49:07 You can't will it away.The rise of BA.5 globally https://t.co/xN9tUBUlla
2022-07-11 17:44:20 Good (new) summary of the @UK_biobank brain study. A larger cohort with paired imaging and matched controls from this exceptional resource is expected later this yearhttps://t.co/91yvemya8L https://t.co/uLBchEop8E
2022-07-11 16:15:59 BA.5 has evolved substantially from its Omicron predecessor variants, now acquiring enhanced cell infectivity like Delta, beyond its formidable immune escape. What are the implications? https://t.co/ibgdJ7yYlI https://t.co/hcw2rZapOH
2022-07-11 15:37:28 @DeepaRamani1 @rosemaryCNN I did thathttps://t.co/ibgdJ7yYlI
2022-07-11 14:53:45 @WHCOS @WHCOVIDResponse @ScottGottliebMD Yes it's critical. So why isn't it being shouted from the rooftops? "You should consider" is a different message than there is a body of evidence to show it's lifesaving.https://t.co/YzhFOuKPDmhttps://t.co/HGyjNwCm0vhttps://t.co/tcGQ0D9aM9
2022-07-11 14:13:30 Discussing the BA.5 variant status with @rosemaryCNN last evening https://t.co/XuLT6zp8XT
2022-07-11 14:03:55 RT @chrischirp: Quick Thread on Covid update in England:Firstly BA.5 and its child BA.5.1 are now the dominant variants and outcompeting…
2022-07-11 13:38:28 What country has a lower booster rate than Iran, Rwanda, Sri Lanka, Azerbaijan, Tajikistan and 61 others? https://t.co/gWCbSb6EfDThe United States
2022-07-11 13:24:33 RT @ddiamond: “BA.5 has taught us once again, the virus doesn’t just get milder and fade away,” @EricTopol writes. “While the virus revs up…
2022-07-11 02:44:04 There's a lot going on with the Omicron BA.5 variant. I wrote a new chapter to update its status https://t.co/ibgdJ7yYlI
2022-07-10 23:49:56 The double whammy of immune escape and increased infectivity
2022-07-10 18:14:53 "BA.5 could mediate not only extensive cytopathiceffects but was also significantly more infectious per diagnostic Ct value compared to the co-circulating BA.2 parental variant.""Appears to have evolved tropism towards pre-Omicron [cell] entry pathways"
2022-07-10 18:14:52 on BA.5 biology"Curiously, the change in BA.5 not only gives the virus greater antibody evasion potential but concurrently has changed its tropism [efficient use of TMPRSS2] along with an increased transmission potential in the community."https://t.co/U0r0ms6Mr7 https://t.co/qgCKTCHKTb
2022-07-10 17:43:58 We desperately need #LongCovid biomarker(s)Many reports show persistent virus antigens, such as this recent small onehttps://t.co/nlrgzWIscM but a few counter https://t.co/pKFX1d7cTfWith millions suffering LC, it's long overdue this gets nailed down w/large, definitive studies https://t.co/kvJFDAMEjE
2022-07-10 16:52:44 https://t.co/czSashfSGL
2022-07-10 16:52:43 An obstetrician writes about post-Roehttps://t.co/5TVVK8X8JO by @DavidNHackney @nytopinion https://t.co/F25ybClbjy
2022-07-10 15:53:35 The @uk_biobank brain study was quite concerning, so this new report is reassuring and welcome. We’ll need more high quality longitudinal studies (like these two) with extended follow-up to sort this out.
2022-07-10 15:20:39 The waste of 1.1 billion Covid vaccines that could have done a world of good to reduce deaths, hospitalizations, sickness and #LongCovid https://t.co/LXSEZObiu4 by @hannahkuchler @FT
2022-07-10 15:05:01 "America has decided the pandemic is over. The coronavirus has other ideas."https://t.co/5uRqAbZ14v by @JoelAchenbach
2022-07-09 23:16:00 @kallmemeg @profesterman @guardian Meaghan, Thanks for your post. I shared @profesterman's piece (an epidemiologist) for his perspective (not mine), which is not in my summary of BA.5 https://t.co/vwK1ZXsU7m.No intent to mislead. I will delete it and let him defend his calculation
2022-07-09 23:07:06 https://t.co/F5uXha5j3w
2022-07-09 23:07:05 Brain imaging &
2022-07-09 18:47:56 Coverage of the new @ONS UK reporthttps://t.co/QuPCZO0kpy @FT @SarahNev w/ comments by @LawrenceYoung11Report https://t.co/Fsb4G7mIKR https://t.co/68AGghg7m9
2022-07-09 18:19:37 BA.5 got started in S. Africa and Portugal. Besides affecting much of Western Europe and the US now, it is leading to new surges in the Asian-Pacific region and South America. In most regions deaths have remained low to date@OurWorldInData https://t.co/CbO1qpeuwA
2022-07-09 01:53:58 The @CDCgov twitter post todayhttps://t.co/Mp2Tfrx5Q0
2022-07-09 01:18:06 @scrivenix Much appreciated
2022-07-08 21:13:40 A systematic review of 43 studies on post-Covid reinfections from 17 countries. Pre-Omicron protection was very high and durable (Left panel)Post-Omicron: substantially lower and declined more rapidly (Right panel)https://t.co/YOFrTTAKzc by @IHME_UW https://t.co/blooSrvaFC
2022-07-08 20:55:54 BA.5 signs on in JapanNearly as vertical as Omicron BA.1, and despite a big BA.2 wave@OurWorldInData and https://t.co/t6RYIZYbFE https://t.co/9Is3zGNZt7
2022-07-08 20:39:23 Link to the @CDCgov site which provides "community level" virus by county, a deceptive and hazardous view of our BA.5 situation now. Hidden behind that on the site is the "community transmission level," as previously shown (and below)https://t.co/cp8qDLJbEn https://t.co/ujP2kooI9J
2022-07-08 20:11:20 @Jlguest Thanks Dr. Guest
2022-07-08 19:14:59 RT @mehdirhasan: Embarrassing. Shameful. Inexcusable.
2022-07-08 18:07:29 New and outstanding @SciImmunology review on #LongCovid and other respiratory viral infection chronic sequelae with particular attention to lung impact https://t.co/iivxZXQIc5by @hnarasim23 @Jie_Immunology @goplenNP @Yue_Wu_IMM @UVA_MIC @MayoClinic https://t.co/ZzuQ95YDlL
2022-07-08 17:17:11 Reference for survival advantage of a 4th shot (2nd booster) for age 50+ (besides 2 Israel @NEJM reports)https://t.co/HGyjNwCm0v https://t.co/TqusVj3d8l
2022-07-08 17:17:10 Reference for 5 days as median for length of infectiousness (best proof is not a rapid test but how long the virus can be cultured)https://t.co/OSIzRKxt33
2022-07-08 16:46:27 This is our @CDCgov X No warning on BA.5X Still says 2 vaccine doses ="fully vaccinated"X Says 5 days is all that's needed for isolation when 5 days is the median length of infectiousnessX 1 in 4 age 50+ w/ 2nd booster (<
2022-07-08 15:56:18 @cellhostmicrobe More on BA.4/5 immune escapehttps://t.co/7yDUJ5vTxqWith simplified street-sign view of its antigenic distance from prior (sub) variants that account for this property https://t.co/pmEH6HvurU
2022-07-08 14:19:30 Meanwhile, here in Californiahttps://t.co/2hpenSZ59k https://t.co/uyNSsW3mgr
2022-07-08 13:57:04 Despite the >
2022-07-08 13:57:03 Why is it the "worst variant" yet?Not because it causes worse disease. There is no evidence for that.Because it is the most transmissible and most immune-evasive of any version of the virus since the pandemic began.https://t.co/vwK1ZXsU7m
2022-07-08 13:34:54 Today's @nytimes BA.5 variant coverage by @LaurenLeatherby https://t.co/DUxqHMgHGz https://t.co/SIeCseZm37
2022-07-08 13:28:23 Today's @washingtonpost editorial on the BA.5 varianthttps://t.co/HLRpQSYBNG https://t.co/eNm00RbBxE
2022-07-08 04:03:06 @mocoband @LaurenLeatherby Yes, thanks. Introduced in Mayhttps://t.co/P7KQmSc8qK
2022-07-08 02:49:51 @mattyglesias @dgmacarthur Agree with @patrickc for what is holding us back. It's not the science, as we wrote about in early 2021https://t.co/eKHGg7EPtM @Nature
2022-07-08 02:45:06 RT @michaelmina_lab: Goes without saying at this point…Test before exiting isolation to know you are no longer infectious(Do not listen…
2022-07-06 23:29:28 It's not just about cases https://t.co/PPN3yKhOXf
2022-07-06 23:26:10 Some countries, like Singapore, have already hit 2nd highest case peak after Omicron BA.1 https://t.co/JEUTK7Kp0Z
2022-07-06 23:26:08 Broadening impact of BA.5 around the world https://t.co/kkpT6Zgodr
2022-07-06 23:10:36 Pharmacists in the US (>
2022-07-06 21:01:00 Understatement:"The rapid emergence of new variants makesvariant-specific vaccine development dificult" https://t.co/kLAuVbkDps@NEJM todaya.k.a variant chasingPan-β-coronavirus and nasal vaccines would avoid V-chasing and can help get is to variant-proof status, ahead of https://t.co/fIsYc3bdlK
2022-07-06 17:33:20 @LeanneGSinger @AshishKJha46 Agree! Instead of throwing away tens of millions of vaccines about to expire, they should be distributing 4th shots to all who want them
2022-07-06 17:22:39 Genome editing for potential definitive treatment or curies for many genetic conditions is moving forward at high velocity. A new @CellCellPress review is a masterful state-of-the-science for deliveryhttps://t.co/SJtJ512NE1 @davidrliu @samagyabanskota @liugroup @broadinstitute https://t.co/jYdghFsF3s
2022-07-06 14:14:15 Such profound waste of tens of millions of vaccines that could have saved lives, prevented hospitalizations, sickness and #LongCovid @Loftus https://t.co/qF8324imGG
2022-07-06 13:41:55 The kind of forward thinking needed to get ahead of the virus, by @CalTech @bjorkmanlab https://t.co/wpLKJ7lgDf@ScienceMagazine Nanoparticles with multiple different #SARSCoV2 receptor binding domainshttps://t.co/EAsUdng9Jx @corinnepurtill @LATMelissaHealy @latimesscience https://t.co/kOPV9d8loA
2022-07-06 13:30:17 Collateral impact of a post-Roe United States—In vitro fertilizationhttps://t.co/5WTmZQp7Zsby @JanHoffmanNYT —Prenatal genetic testinghttps://t.co/4Qmct1kcYY @CellRepMed by @MAllyse and @MarshaMichie https://t.co/nKZuGhc64G
2022-07-06 13:18:35 More on this from brain neuroinflammation in 24 patients and matched controlshttps://t.co/t8JQqSx5B8 5 severe Covid patients had #SARSCoV2 immunoreactive neurons in brainstem nuclei https://t.co/GzfT2gjVMF
2022-07-05 23:42:26 The microvascular injury and inflammation of the brain, with immune complex formation, that can occur from Covid, from in-depth assessment of 9 patient autopsies and controls. https://t.co/AWbo70nrBK by @NINDSnews https://t.co/oiBC8lXygI
2022-07-05 23:03:26 US CDC genomic surveillance updateBA.5 growth marches on, now 54%BA.4/5 combined >
2022-07-05 15:05:04 For both 2020 and 2021, Covid was the 3rd leading cause for death in the United States, by @theNCI @JAMAInternalMed In 2021, it was the #1 cause of death in Americans age 45-54 https://t.co/hFcvKAomER https://t.co/pH8sBTbLz5
2022-07-04 19:01:00 Hello BA.5 https://t.co/kZK5Ss0Ofh
2022-07-04 18:17:21 RT @shannonrwatts: Having unfettered access to 400 million guns isn’t freedom. Being able to take your kid to a Fourth of July parade witho…
2022-07-04 16:57:38 The promise of individualized medicine for systemic autoimmune rheumatic diseases https://t.co/CS5TbPUmqL A new @NatureMedicine review@guthridgej @OUHealth @OMRF https://t.co/Y1qOLMZCs1
2022-07-04 16:34:16 —I'd like an inhalable Covid vaccine with exosomes decorated by #SARSCoV2 receptor being domain—Sure, here it ishttps://t.co/RSBJaVNzm0 @NatBMESeriously, we need nasal spray vaccines
2022-07-04 15:39:32 If you're into #AI for healthcare, an essential new review article @natBME today https://t.co/3F0row83l6@Joseph_C_Wu @james_y_zou Angela Zhang @StanfordMed @StanfordCVI https://t.co/ljeO8Mji7J
2022-07-04 15:08:29 The basis for concern about the Omicron BA.2.75 variant. 8 mutations beyond BA.5, many in the N-terminal domain, which could make immune escape worse than what we’re seeing now. Competing w/ BA.5 in India. Excellent thread by @EllingUlrich https://t.co/Ko5AYxEonv
2022-07-04 14:50:22 @mebottazzi Congratulations for this richly deserved recognition!
2022-07-04 14:38:21 Celebrating Great Immigrants, Great Americans, the essential contributions of immigrants to American LifeSuch as @ardemp &
2022-07-04 03:49:38 RT @Bob_Wachter: Covid (@UCSF) Chronicles, Day 838The die is now cast: BA.5 is destined to be our dominant virus. In today’s I discuss t…
2022-07-04 01:22:02 RT @deschiam: If you do nothing else please read this. I get the fatigue but this is not doom and gloom. There is a path out but we have to…
2022-07-03 17:20:11 Relevance to Omicron infections"Omicron infection had little or no beneficial effect of boosting any part of the immune system — antibodies, B-cells or T-cells — among people who had been imprinted with earlier #SARSCoV2 variants"https://t.co/PE4QjMv69U@ScienceMagazine
2022-07-03 16:43:08 Impact on optimizing boosters, timing, and next-generation of Covid vaccines"Patterns of anti-spike immunity in different people and populations have become heterogeneous, complex and unpredictable"by @clivecookson @JamieSmythF @ian_bott_artist https://t.co/z4dT40Fwjy
2022-07-03 16:43:07 What is immune imprinting and why it is important?A superb explainer“Our first encounter with the spike antigen, either through infection or vaccination, shapes our subsequent pattern of immunity through immune imprinting" —@BoytonRosemaryhttps://t.co/OYMd5RRe1j https://t.co/8hfXjGno29
2022-07-02 23:28:27 Small study of health care workers suggests possibility that there may be increased protection from #LongCovid with increased doses of vaccine https://t.co/1tBWtHdsJM @JAMANetworkOpen https://t.co/n0OhnsxTRL
2022-07-02 20:50:29 @RajlabN @Mike_Honey_ Thanks. But I’m referring to sign of growth of BA.2.75 here. Not 2 isolates. We’ll obviously be seeing more if it in the days ahead
2022-07-02 19:13:09 Connecting the dots for these 2 sequential @KPSCalResearch reportsVaccine effectiveness vs hospitalization, 3 mRNA shots, <
2022-07-02 18:13:38 Omicron subvaraints in the US—BA.5 is likely >
2022-07-02 17:09:46 @DianaGHealth @MiamiDadeCounty Yes, concerning, and across the US test positivity only exceeded during initial Omicron wave
2022-07-02 16:45:00 Be careful out thereOn the way up. US Covid cases, hospitalizations and deaths. BA.4/5https://t.co/QPRo6jaOkahttps://t.co/g9qEGacIrz https://t.co/4230aNMcKj
2022-07-02 16:24:03 The same @KPSCalResearch group previously published their data with 2 or 3 mRNA shots over time for Delta and Omicron. Vaccine effectiveness vs hospitalization vs Delta was 89% (95%CI 83-93) for <
2022-07-02 16:24:02 A reminder that prior to Omicron vaccine effectiveness with 3 mRNA shots vs symptomatic disease (and hospitalization) was ~90% for at least 3 monthshttps://t.co/pKg2TyidP5@ScienceMagazine w/ @GuptaR_lab https://t.co/B9RwRzyfCV
2022-07-02 15:57:05 The need for better vaccines vs Omicron subvariantsReduction in 3-shot mRNA vaccine protection vs Emergency Department admission from BA.1 to BA.2 (5% at ≥ 3 mos) https://t.co/mxSyJaHRmN3-shot vaccine effectiveness vs hospitalization 80% BA.1, 74% BA.2 at <
2022-07-01 20:21:16 RT @EricTopol: Has the @CDCgov warned you about BA.5, now accounting for ~37% of Covid cases, a liability for reinfections, less protection…
2022-07-01 17:58:16 I guess the CDC woke up today on thishttps://t.co/hmQq0numog
2022-07-01 17:01:01 RT @john_actuary: Another 39% increase in today's admissions figure, to 1,572, bringing the weekly average to 1,290, itself up 34% on the w…
2022-07-01 16:47:13 "It is both perplexing and not a little devastating that this mysterious, lingering disease finds a way to continue wreaking havoc in the face of a largely vaccinated population and a supposedly milder variant."—@Daltmann10 https://t.co/NbWldSRi0Q @guardian via @JeremyFarrar
2022-07-01 15:39:50 The importance of investigating unexpected findings:the role of a silent KRAS gene variant in cancerhttps://t.co/J1MjkFTbZa by @molina_arcas @JulianDownward @NEJM https://t.co/51sToFMIxH
2022-07-01 15:23:51 Hospitalizations for croup in children with Covid rose substantially with Omicron BA.1.1https://t.co/3b9qQ0COxf @JAMANetworkOpen https://t.co/TsbMaY8S7J
2022-07-01 14:55:01 How does BA.5 spread so fast and what we can do about ithttps://t.co/vwK1ZXsU7m
2022-07-01 14:46:06 The rise of BA.5 globally https://t.co/OoY95naYJp https://t.co/ru4EuNrlAV
2022-07-01 14:34:40 The BA.5 variant: here, there (UK) and everywhere, on a path to global dominancehttps://t.co/drfdJlqjOM @clivecookson @FT https://t.co/3B9h8mrm5w
2022-07-01 05:06:51 RT @JPWeiland: Positivity rates have only been higher two times since the beginning of the pandemic. The first weeks of the pandemic, and…
2022-07-01 00:45:58 RT @AI4Pathology: Our @TheLancet perspective w/ @EricTopol highlights key findings from our recent @NatureMedicine article about AI-driven…
2022-06-30 22:57:49 Can #AI promote accuracy of diagnosing organ transplant rejection?Our new @TheLancet essayhttps://t.co/0kLA0JlBrpw/ @AI4Pathology @BWHPath @harvardmed @broadinstitute and their colleagues recent work https://t.co/KgDBuwDlgc @NatureMedicine https://t.co/piSnqdtn2b
2022-06-30 22:39:03 The 3 figures from the study to convey these 2 points https://t.co/ygFwdSJWqI
2022-06-30 22:34:55 Largest study of BMI and Covid vaccination—Underweight/low BMI less likely to get vaccinated + severe disease risk after 2nd dose higher in than in people w/normal to high BMI (need 3rd shot)—Obesity did not impact vaccine effectivenesshttps://t.co/nrEtKhwowK @TheLancetEndo https://t.co/X8I4xEBSbI
2022-06-30 20:25:54 Impact of "The hiatus of the handshake"https://t.co/ML50IIZvDV @ScienceMagazine @kbratnelson @B_Lopman @EmoryRollins @EmoryEPI A thoughtful essay on what we've learned from the pandemic, the rippling effects on other infectious diseases spread, &
2022-06-30 20:18:22 How it's going hereHospitalizationsICUsDeaths https://t.co/q39jhVwoiP
2022-06-30 18:53:24 It seems like almost every day there is another major discovery of broad, neutralizing antibodies to #SARSCoV2 that could be the foundation for pan-β-coronavirus vaccinesYesterdayhttps://t.co/53pFFnNx9gTodayhttps://t.co/rGEXabRCJF https://t.co/qANrWz3ybF
2022-06-30 18:47:20 A new, tour de force review of the gut microbiome and its implications for health and disease https://t.co/jOIuUaF60l @ScienceMagazine @abaumler @TsolisRenee @Jeeyon84 @ucdavis https://t.co/0R94eGpbt4
2022-06-30 16:37:29 @RobertoBurioni @ScienceMagazine @NewsfromScience @RobertFService Hope you are right, RobertoSince the potential exists, it would be ideal to have other drugs and combinations ready
2022-06-30 16:07:51 Here's the US Covid hospital admissions, log-scale, with BA.5 on the rise https://t.co/icf7bUryc4
2022-06-28 16:57:53 RT @Bob_Wachter: Great BA.5 primer by @EricTopol. Key points:1) Will be dominant variant soon2) infectious &
2022-06-28 15:16:51 @buzzindelhi @DrAmbrishMithal Yes
2022-06-28 15:13:46 Maternal mortality in the United States, highest of all 38 @OECD countries, increased during the pandemic and now, with banning of abortion in many states, is positioned to go even higher, w/ disproportionate impact by race and ethnicityhttps://t.co/HwPyEHs6ty @JAMANetworkOpen https://t.co/NBlQEm0M5m
2022-06-28 14:55:19 The comprehensive list of the actions taken during the pandemic to get ahead of the virus https://t.co/QxKHUKCz9v
2022-06-28 14:46:01 Note there is no BA.1 while the @US_FDA Advisory Committee debates today the merit of an EUA for a BA.1 booster that has a 3-fold drop in neutralizing antibodies vs BA.4/5https://t.co/6X3AwmEfol https://t.co/18vu12n7e4
2022-06-28 14:31:58 The BA.5 variant is now 37% of Covid cases in the US, and the BA.4/5 combo has now overtaken BA.2.12.1 to become dominanthttps://t.co/jjl2AnwOWX https://t.co/7xWs8tKUfb https://t.co/K6FuxPaxP2
2022-06-28 14:11:11 10 years ago today a @ScienceMagazine online paper with an obscure title turned out to be the beginning of the most important life science breakthrough in many decades: #CRISPR genome editinghttps://t.co/y23NPGumVV @carlzimmer https://t.co/gO4JoMgUkA
2022-06-28 02:20:03 This variant is center stage for the @US_FDA Advisory Committee hearing tomorrow about updating vaccines and the question of (EUA) approval of an Omicron (BA.1) booster (a variant that is no longer circulating)https://t.co/eHgCgUvnO0 by @SharonLNYT
2022-06-28 02:11:33 When it comes to #SARSCoV2 and Covid, it's important to keep your eyes on the ball. The ball is BA.5 and here is what we know about ithttps://t.co/vwK1ZXsU7m https://t.co/qaH1eTdqPO
2022-06-27 21:18:58 RT @chrishendel: "It’s frankly sickening to watch this virus continue to outrun us, knowing we are so damn capable of getting ahead of it"…
2022-06-27 20:51:08 I wrote about about the Omicron BA.5 variant: (1) what we know about its biology
2022-06-27 16:08:16 A new outstanding review on the antibody response to #SARSCoV2 https://t.co/7NbLF1HBQy @NatImmunol and the path to variant-proof Covid vaccines https://t.co/hnZnCnyzYr
2022-06-27 15:15:55 The promise of digital health. Our new @theNAMedicine perspective piecehttps://t.co/SfNm1YwuAu "A digital health ecosystem that provides high-quality, personalized, equitable care to all who need it is achievable and worthy of our best individual and collective efforts." https://t.co/8jE2J5OTjr
2022-06-27 14:05:42 Canada has done remarkably well throughout the pandemic compared with peer countries (G10) for major outcomes and vaccinations https://t.co/nJflYNqLHY @CMAJ https://t.co/3lWZOii6iQ
2022-06-26 17:35:28 A timely an important update, thread from @jburnmurdoch on this https://t.co/EA7K4i81wn
2022-06-26 17:26:11 As the world turns to BA.5 https://t.co/cqbVuPTjp8
2022-06-26 15:09:00 BA.5 has the most transmissibility and immune escape of any version of the virus since the pandemic began. Although its spike(S) sequence is nearly the same as BA.4, there are several mutations in other parts of the virus that may account for itsfitness https://t.co/nKnmp5OBZK https://t.co/dUsPxu2LIL https://t.co/9feAvwKAMY
2022-06-26 14:45:10 @thehowie That's incredibly kind of you, Howie. Deep thanks!
2022-06-26 14:41:53 This is the simple graph that should have been in the paper, #dataviz from @TheEconomist for saving ~20 million lives in the first year of Covid vaccinationshttps://t.co/bFNPnYyPCd @ECONdailycharts https://t.co/7WDD0YoJ4O
2022-06-25 19:48:49 RT @IAmPoliticsGirl: A court that abandons its own precedent, undermines its own authority. https://t.co/uZOtzRYQtX
2022-06-24 19:12:14 The BA.5 variant is a beast w/r to immune escape and transmissibility—UK report today on its growth advantage relative to BA.2.12.1 and BA.4https://t.co/VW6RafyHNK—San Diego wastewater todayhttps://t.co/rqPGc1qN24 https://t.co/D695PIeDFb
2022-06-24 16:49:54 A real CDC would be aggressively disseminating these data and doing everything possible to prevent unnecessary deaths from Covid https://t.co/Qj3lAZ8K4y
2022-06-24 15:33:11 "The editors of the New England Journal of Medicine strongly condemn the U.S. Supreme Court’s decision."https://t.co/m4wmq0ipFz https://t.co/NZa3rGpEYl
2022-06-24 15:15:35 RT @EricTopol: This week @TheLancet's cover https://t.co/Fnj8uzkJTn
2022-06-24 14:26:27 RT @luckytran: Today, the CDC Director flippantly dismissed the importance of counting rapid tests."You don't need to count the rain drop…
2022-06-24 14:17:44 @clivecookson @alexisak @OurWorldInData @FT @jburnmurdoch @JamieSmythF Thanks Clive. Yes, well shown here https://t.co/zEKob7UFZr
2022-06-24 14:12:01 the bigger picture https://t.co/RQtShVeZsi
2022-06-24 13:57:20 @alexisak @OurWorldInData @FT @jburnmurdoch @JamieSmythF Yes, I cited ithttps://t.co/pu7tSg4YwBBut a lot more is happening since then (and beyond Europe) attributable to BA.4/5
2022-06-24 13:31:13 The rise of BA.5 in Israel https://t.co/zMQih3Ym2g
2022-06-24 13:12:13 Not just England. The BA.4/5 wave in Europehttps://t.co/TMJf6Au4cJ and @OurWorldInData https://t.co/xs8gY8MLSQ
2022-06-24 01:46:18 RT @EricTopol: New @CDCgov data on 2nd booster protection from death for people age 50+, compared with unvaccinated, through Omicron BA.1,…
2022-06-24 00:05:47 "Trust in science has actually become a matter of life and death.”—@NaomiOreskeshttps://t.co/qCmowtRfHI @TheLancet Cover and profile of Professor Oreskes https://t.co/DMeuvBJjgF
2022-06-23 22:30:00 @TheLancetInfDis In the 1st year of Covid vaccinations, ~20 million deaths were prevented worldwide (data from 185 countries)Another ~600,000 lives would have been saved if the @WHO 40% target been achievedhttps://t.co/BWig83xlnN @azraghani @imperialcollege @MRC_Outbreak https://t.co/lF8biBJIlK
2022-06-23 21:57:17 A new study of the "atomic-level dynamics by multiple microseconds simulations" for how the #SARSCoV2 spike gets modified to more efficiently enter host cellshttps://t.co/Pybvy05L2q@PNASNews https://t.co/Z1Q3cPpP86
2022-06-23 19:10:46 Just out @ScienceMagazine "Our findings highlight the urgent need to find next-generation COVID-19 vaccines and broad-spectrum therapeutics, as well as to tighten non-pharmaceutical measures to reduce acute and chronic disease burden (#LongCovid)..."https://t.co/LGBn3krkEf
2022-06-23 19:06:08 The antigen distance map of #SARSCoV2 variants through BA.1 and BA.2 "BA.1 and BA.2 both escape vaccine-induced antibody responses as a result of different antigenic characteristics" Needs a BA.4/5 update, off the chart https://t.co/GGYW6AaMdF @SciImmunology https://t.co/GoE6YC14wz
2022-06-23 18:32:43 A bacteria, as a microbe, is expected to only be visible via a powerful compound microscope. Until this one that was discovered to be macroscopic, reported today @ScienceMagazine https://t.co/KjRYmaU1hA @PetraLevin Easy to remember its name if you like very large margaritas https://t.co/VzeWmuyMM4
2022-06-23 17:56:40 @AstroKatie No good reason. See US hospitalization data by age groups https://t.co/M2Bu9rj1Ve
2022-06-23 17:35:09 https://t.co/ibU6PHvkpR
2022-06-23 17:35:08 The Israeli researchers nailed this down back in February and have published extensively on the protection of the 4th shot for reducing death and severe diseasehttps://t.co/W4xkPskVdP
2022-06-23 16:23:17 Only 1 in 4 Americans age 50+ have had a 2nd booster. https://t.co/k1hTZD8CciPlease go for it. It could be lifesaving.
2022-06-23 16:19:26 New @CDCgov data on 2nd booster protection from death for people age 50+, compared with unvaccinated, through Omicron BA.1, BA.22 boosters: 99% reduction 1 booster: 86% reductionVaxx, no boosters: 81% reductionhttps://t.co/HGyjNwCm0v https://t.co/yaEtuClQA5
2022-06-23 16:07:49 RT @kallmemeg: A little sent me these. The BA.4/5 wave is here… https://t.co/ojQ7b2TNgQ
2022-06-23 16:04:22 The trajectory in Englandhttps://t.co/UzmuMktkq5
2022-06-23 15:48:42 More @TheEconomist today on @mcuban's @costplusdrugs and @CivicaRx efforts to take down drug costshttps://t.co/jJH6hmH3sq https://t.co/iiRyMe6QKZ
2022-06-23 14:51:28 On the amazing 300 million smell receptors in dogs that can sniff out Covid and diseaseshttps://t.co/f6opxKX7lU@nature @PVWDCvet @juliannaphos https://t.co/oY89CE4O4o
2022-06-23 14:22:57 A new systematic review of #LongCovidKids https://t.co/GP73U57KOb https://t.co/8IVwtzpwXl
2022-06-23 02:42:26 A few added mutations in the spike sequence (BA.4/5) are leading to even more immune evasiveness and a new Covid wave in many places around the world https://t.co/xMlXAyb6VY
2022-06-23 01:44:40 "Astoundingly, they found that more than 78% of all the CTCs obtained were from the samples taken during the resting [sleep] phase."https://t.co/nQVG1s5pLA@NatureNV https://t.co/eJZbKkU2gT
2022-06-23 01:34:39 The exact opposite:@VirusesImmunity tips for 1st rate science communication on @Twitter https://t.co/qPqFWGJBCs@NatImmunol https://t.co/0cZSsalGfC
2022-06-22 22:57:27 Accompanying editorial https://t.co/u28w8wyG6Pby @skr9skr9 and Denise Jamieson https://t.co/XHa1dBDX7X
2022-06-22 22:30:13 Largest study of #LongCovid in kids, a nationwide Denmark report with age-sex-matched controls @LancetChildAdol Higher odds of >
2022-06-22 21:49:14 How vaccinating 1 person protects 2Expectant mothers and their newbornshttps://t.co/CgARnJzAab https://t.co/BH0VOBuBDT
2022-06-21 21:43:55 A new report on Covid reinfections is particularly concerning. I've written about it here https://t.co/2dRK90OeoV
2022-06-21 19:11:55 The link to this important report is now active https://t.co/iOHqC3ulET
2022-06-21 18:09:47 A wake-up call for drug-gene interactionshttps://t.co/CufZhaKPp9by @CeciliaChung11 and colleagues @VUMChealth @VUMC_Medicine @VUMCClinPharm https://t.co/Cm6nK5Ji0X@AnnalsofIM https://t.co/3TV4Ztl2Iz
2022-06-21 17:00:13 New @CDCMMWR reports Real world evidence for Paxlovid efficacy, striking increase in prescriptions, and their mismatch in places of high vulnerability/needhttps://t.co/HCMlSrgrK4https://t.co/NB76ONZDPi https://t.co/ScUIGIQbum
2022-06-21 16:22:26 Sorry, meant to link this risk of reinfection paperhttps://t.co/AiV7P6hQLO
2022-06-21 16:18:49 Before Omicron the chance of reinfection was ~1%. That has markedly increased w/ Omicron, especially for BA.4/5 with reduced protection from BA.1 infections. Reinfections carry substantial risk, as shown in this new analysis, so please keep your guard uphttps://t.co/Rx6p2lLw66
2022-06-21 15:28:32 The BA.4/5 impact is just starting to take hold, with no region of the US at a dominant level yet. It is also on a path to dominance in multiple countries in Europe, and Australia, with some attributable increases in hospitalizations https://t.co/pu7tSg4YwB https://t.co/CO1gfjwKSQ
2022-06-21 15:23:01 BA.4/5, the Omicron subvariants with the most immune escape (and highest transmissibility) since the pandemic began, now account for 35% of new cases in the United Stateshttps://t.co/jjl2AnwOWX https://t.co/teIGeGTUVC
2022-06-21 15:01:58 Americans spent ~$50 billion on vitamins and supplements in 2021. A new systematic review of 84 studies shows they are a "waste of money," lacking value in non-pregnant adults, and specifically risk of beta-carotene and lack of Vit E effect @JAMA_current https://t.co/mTPSw1u7kp
2022-06-21 14:36:06 Having so many new and repeat infections during a prolonged Omicron subvariant wave (BA.2.12.1, BA.4/5) with their toll on sickness and #LongCovid should not be comforting or give anyone the impression this is behind ushttps://t.co/FrGtjbmmf2 https://t.co/8WzkZSI2FD
2022-06-21 14:24:54 For those questioning about peer review, these authors have published extensively on Covid cardiovascular outcomes https://t.co/bCXl6MEeP0, breakthrough infections and #LongCovid https://t.co/2JUuTasGDVdiabetes, mental health, kidney disease, and morehttps://t.co/mT5sylrfy4
2022-06-21 01:27:07 RT @mcuban: Hey @JoeBiden , @LeaderMcConnell, @SpeakerPelosi , @GOPLeader, @SenSanders @RonDeSantisFL @AOC have your people call my peop…
2022-06-21 01:19:30 Covid reinfections are not benign: ~39,000 people w/reinfections vs ~5.4 million controls indicates extensive and persistent risk with a "dose-response" (more risk with repeat reinfections) https://t.co/v8nZXBEuNdby @zalaly @BCBowe @Biostayan @WUSTLmed @VAResearch https://t.co/U4pPQZLEaB
2022-06-21 00:21:08 Text and more data from the reportNote the vaccines that participants had received were Sinopharm (BBIBP-CorV) and Anhui Zhifei Longcom (ZF2001) https://t.co/jKAs8p4hIb
2022-06-20 23:58:35 Post-vaccination breakthrough infections with Omicron subvariants (BA.1, BA.2) lead to a narrow, specific neutralizing antibody response setting up vulnerability to BA.4/5 https://t.co/Kf7hDxZaf1 @TheLancetInfDis https://t.co/gkwj8XpVIX
2022-06-20 21:27:35 The new paper was based on <
2022-06-20 21:17:53 Table from the paperAnd https://t.co/sH9CNbZPAlExamples for 2 of the most frequent drugs I prescribe vs retailLisinopril for BP ($3.60 vs $24)Atorvastatin ($3.60 vs $55.20) https://t.co/V5EK6vCb9h
2022-06-20 21:10:04 The many $ billions the US could save each year by @mcuban's @costplusdrugs (MCCPDC) is remarkablehttps://t.co/3vVXM2TbnL@AnnalsofIM @BrighamWomens by @DrHussainL @PORTAL_Research @akesselheim @bnrome https://t.co/eyGwDewo1x
2022-06-20 19:34:35 Speech and spread of #SARSCoV2 "Our results suggest that the quantity of speech aerosol, in particular in the ≥ 4-μm range, may have been strongly underestimated in many prior reports"https://t.co/z4z0xj4h3g <
2022-06-20 19:07:19 "What SARS-CoV-2 does to our brains"https://t.co/8c7ORLBvgr @ImmunityCP potential of immune systems response both acutely and w/ #LongCovid @HelenaRadbruch @f_heppner @ChariteBerlin https://t.co/ktFYe6QHlS
2022-06-20 17:58:35 Deep learning #AI to rapidly identify new driver mutations in 37 types of #cancerhttps://t.co/C6V85OgfSjby @MIT_CSAIL @lab_berger @m_a_sherman @olivercpriebe @AdamYaari @NatureBiotech https://t.co/SQCdzRFZBS
2022-06-20 17:43:14 “I don’t think there can be any doubt in anyone’smind that these are a source of new variants”—@GuptaR_lab https://t.co/YXiaN6j12K @Nature by @ewencallaway https://t.co/xBoipvrpT8
2022-06-20 17:37:55 RT @NatureBiotech: Smartphone apps in the COVID-19 pandemic https://t.co/0VLZ5LGAVQ https://t.co/oyfsFNHPLo
2022-06-20 16:12:42 The role of digital surveillance and real-time individualized risk assessment throughout the pandemic has not been adequately emphasized
2022-06-20 16:00:54 The evolution of #SARSCoV2 in immunocompromised people with chronic infections is driven by immune evasion, especially seen w/ viral rebound, and requires extensive genomic monitoring for detection of new VOCs @NatureMedicine https://t.co/GFK4nW10Lj https://t.co/cNF1ivKViU
2022-06-20 15:12:55 Just published @NatureBiotechOur review of smartphone apps for Covid-19: outbreak epidemiology, individual screening, contact tracing and their futureby @JayPandit @jmradin @GiorgioQuer @ScrippsRTI @scrippsresearch https://t.co/NswHMmNmRl https://t.co/9pNO2VCnde
2022-06-19 16:14:33 How the pandemic is catalyzing innovations1. https://t.co/G5aKL6z8IX @NatureMedicine 2. https://t.co/6l2aW15kRF3. https://t.co/KUc1KWIyQP https://t.co/U8xnQc8JoC
2022-06-18 21:25:39 RT @Medscape: .@EricTopol speaks with @DeepMind CEO @demishassabis about harnessing the potential of AI in health and medicine. https://t.c…
2022-06-18 16:51:09 How can you go from sequence of a novel virus to 2 vaccines with 95% efficacy and safety (>
2022-06-18 16:43:11 ‘Why aren’t we having a vaccine...that gives you a 5- or 10-year duration of protection like most vaccines?"— @PeterHotez
2022-06-18 16:43:10 ‘‘In terms of what really keeps me up at night, it’s the knowledge that we can’t keep boosting."—Dr. Peter Marks @US_FDAhttps://t.co/gLmtGp2WTf by @StephArmour1 https://t.co/j22vTDxmDo
2022-06-18 15:11:18 Concerns echoed herehttps://t.co/4VT2MQVphu"Uğur Şahin warned that a sub-variant of Omicron that fully escapes vaccines’ protection might emerge as countries prepare to launch autumn booster campaigns"@hannahkuchler @JamieSmythF https://t.co/RwBbG1nDih
2022-06-17 19:12:07 More on this from @chrischirp @bmj_latest https://t.co/S0MsyPqwJV https://t.co/sSYi3djtey
2022-06-17 17:01:47 Parts of the text https://t.co/aPjzqIc5lI
2022-06-17 16:56:44 The Omicron BA.4/5 subvariants are leading to a new wave in Europe and the United States, with an impact of some increase in hospitalizationshttps://t.co/y0LvkzoCRb @SarahNev @JamieSmythF @jburnmurdoch @TWenseleers https://t.co/pBuS7Xc5Li
2022-06-17 16:41:58 A noteworthy failure of individualized medicine (or amyloid hypothesis) for prevention of Alzheimer's disease: a randomized, placebo-controlled trial of a monoclonal antibody for people w/ presenilin 1 mutation (amyloid precursor) failed to show benefithttps://t.co/e5cwN4UIsY https://t.co/KAG3AjfpQZ
2022-06-17 15:18:31 Just published @Nature The extent of immune evasiveness of Omicron subvariants BA.2.12.1 and BA.4/5 raises concern about effectiveness of the Omicron (BA.1) specific vaccine booster impacthttps://t.co/foDTHDo49p https://t.co/2WmXQHmRwr
2022-06-17 15:08:07 Oh, really?
2022-06-17 03:11:51 A review of what we know about 3 theories that may represent underpinnings of #LongCovid @ScienceMagazine: (1) microclots, (2) persistent virus, and (3) immune system gone haywirehttps://t.co/KuY8N9dVp6
2022-06-17 02:40:13 Substantial (~50-75%) reduction of #LongCovid with Omicron compared with Delta variant, magnitude influenced by age and time since vaccination @TheLancet https://t.co/shAzJn8WSj https://t.co/bXoct0sXd1
2022-06-16 16:55:35 There's only 1 person who fits this profile and he's one of the leading forces in the world for advancing #AI, solving intelligence, and fortunately for us much of that work is in life science, such as #AlphaFold https://t.co/vqUEkGqvzyA conversation with @demishassabis https://t.co/XmvkX8fLA2
2022-06-16 16:33:26 The genetic distance (GD) of #SARSCoV2 variant's receptor binding domain predicts vaccine effectiveness vs symptomatic infections (from ~2 million sequences, 49 studies, >
2022-06-16 02:37:51 RT @demishassabis: Thanks for having me on the podcast @EricTopol, was one of the most fun and wide-ranging conversations I've had, discuss…
2022-06-15 21:28:21 3. 3-shot mRNA vs Omicron hospitalization had 77% (95% CI 71,82%) effectiveness in 21 US hospitals https://t.co/EbI5MRTM1O https://t.co/anG7253CWr
2022-06-15 21:28:19 2. Continued "That previous #SARSCoV2 infection history can imprint such a profound, negative impact on subsequent protective immunity is an unexpected consequence of COVID-19" —@BoytonRosemary @Daltmann10 and colleagues @ScienceMagazine https://t.co/dFtjfp9cGY
2022-06-15 21:28:18 A 3-fer on Omicron infections1. Vaccine protection vs BA.1 and BA.2 variants similar, national Qatar study https://t.co/VVcQuMSNqR @NEJM2. Evidence of imprinting ("antigenic sin") by ancestral or Alpha infections w/ reduced immune response to Omicronhttps://t.co/PE4QjMv69U https://t.co/WVT2M6xKBt
2022-06-15 17:34:25 I’ve done a lot of interviews over the years, but I can’t remember one as enthralling as this one with @demishassabis on #AI, #alphafold, foundation models and the future of biomedicine @DeepMind w/transcript https://t.co/vqUEkGqvzy
2022-06-14 15:56:02 @FSBuchholzer @KasperKepp @apsmunro Actually, your accusation &
2022-06-13 22:52:54 RT @EricTopol: "We estimated that a single-payer universal healthcare system would have saved 212,000 lives in 2020 alone. We also calculat…
2022-06-13 20:33:08 “But the threat – mostly of long-term problems – seems too big to ignore.”Thanks Bob for this very important thread https://t.co/BkQzKexv5m
2022-06-13 20:14:03 Link to paper https://t.co/eNKJhkt1GX w/ @MeaganCFitz @AlyssaParpia @abhiganit and collaborators
2022-06-13 20:14:02 "We estimated that a single-payer universal healthcare system would have saved 212,000 lives in 2020 alone. We also calculated that US$105.6 billion of medical expenses associated with COVID-19 hospitalization could have been averted by a Medicare for All system."@Alison_Galvani https://t.co/cbE58eBprh
2022-06-13 17:39:27 Dr. Monje's excellent https://t.co/NxZp0l89Bn
2022-06-13 17:37:35 "We explored the neurobiological effects of [mild] respiratory SARS-CoV-2 infection and found white-matter-selective microglial reactivity in mice and humans" Parallels to chemo-brainhttps://t.co/R8LoXsCDcO @michelle_monje @VirusesImmunity @ThisIsAnthonyFC @CellCellPress https://t.co/Fq1QlopJiF
2022-06-13 16:26:26 @euanashley Thanks Euan
2022-06-13 16:22:43 The Peizo1 ion channel protein was found to trigger cardiac hypertrophy, with important potential implications for an unmet clinical needhttps://t.co/0aRm4vGekL@NatureCVR @VictorChangIns @BorisMartinac @justsaysinmice https://t.co/W1IswsfQLI
2022-06-13 15:32:53 @NatureBiotechA rapid (<
2022-06-13 14:40:24 "These kinds of vaccines could buy us long-lasting protection against infections and disease. When combined together, our armamentarium for fighting Covid is growing" On the potential of nasal and pan-β-coronavirus vaccineshttps://t.co/UhoGKQdBFO by @deeptabhattacha @nytopinion
2022-06-13 14:33:15 A cluster of unprecedented reports of individualized medicine for cancer—I've tried to summarize and contextualize here https://t.co/uM9vNK1tF3
2022-06-13 14:03:59 Our covid times by @BruceEricKaplan https://t.co/6iLFDoKcfC
2022-06-12 23:01:00 Our brains get hotter than anticipated: 1st 4-D map of healthy human brain temperature indicates deeper brain regions often exceed 40°C, especially for women during the daytime https://t.co/o0Xdm5f7d9 by @Neurocool and colleagues @MRC_LMB @Brain1878 https://t.co/Sx0d8uvDzo
2022-06-12 22:25:39 Worthwhile insights on this from @karpathy and @cajundiscordian https://t.co/kRzal3bFeJ
2022-06-12 18:29:05 Covid in Colorado https://t.co/wS1wyTXwit
2022-06-12 17:45:37 To contextualize this post, in particular, that has evoked considerable interesthttps://t.co/CPwDqlV2KD
2022-06-12 17:45:36 A Google engineer @cajundiscordian claimed it was and was put on paid administrative leave for violating its confidentiality policy https://t.co/RM1wwUELfN by @nitashatiku with balanced perspective https://t.co/UJHZmbROJL
2022-06-12 17:45:35 We're well into the 3rd "large-scale" era of machine learning https://t.co/0vEjA39edE which has given rise to Foundation Models https://t.co/HK0FYbahd4 and a recent controversy about whether LaMDA, a language model, is sentient #AI https://t.co/KUsH9mc8vX
2022-06-12 16:06:24 @BlocknixBibi You are VERY wrong. The Covid pandemic is not just about deaths. There's this thing called #LongCovid affecting millions, you fail to acknowledge. There are millions of people sick right now, and hundreds of thousands in hospitals around the world for Covid, many in the ICU
2022-06-12 15:39:21 "73 percent of people who die of cancer had cancers that are not detected by standard tests" https://t.co/vwK8yOY7hYCould a new $949 blood test change this?Not yet. I wrote about it here>
2022-06-12 15:12:36 The mysterious acute hepatitis in children is being called Long Covid Liver https://t.co/nuW0jyhQk5
2022-06-11 22:43:39 RT @VirusesImmunity: A brilliant &
2022-06-11 22:34:18 BA.5 is on the rise in Australia, toohttps://t.co/0wnV0URdjp
2022-06-11 22:21:48 RT @DKThomp: “I believe this is the first time this has happened in the history of cancer”https://t.co/gaEMq13lH7Here is the shot of ne…
2022-06-11 22:20:25 RT @PeterHotez: It’s really interesting @EricTopol how the same subvariants are now producing such widely divergent public health effects i…
2022-06-11 19:25:19 @berthacoombs Masks, distancing, ventilated, filtration etc
2022-06-11 18:55:56 Not every day you see 3-year follow-up of one-shot genome editing to keep 31/31 people with severe sickle-cell disease without any crises and 42/44 with beta-thalassemia without transfusionshttps://t.co/QpFJGa1Kxr #EHA2022 @CRISPRTX
2022-06-11 18:27:57 https://t.co/d7VsfmoKYb
2022-06-11 18:27:56 https://t.co/aAhdTjOihA
2022-06-11 18:27:55 Last week BA.4/5 accounted for 13% of new cases in the US (95%CI 9,18%)Note the biologic features of these 2 variants in the posts below https://t.co/90n2CrRkzx
2022-06-11 18:15:27 Not a good idea to capitulate when the #SARSCoV2 variants with the most immune escape since the pandemic began are into exponential growth, especially when there's so much that could be done beyond the usual measureshttps://t.co/N5zk6WaGIt
2022-06-11 18:15:26 US cases are still rising, 7% increase week-to-week, >
2022-06-11 18:00:05 BA.4/5 is on the rise to become dominant in the US and UK. It hit South Africa and Portugal first. Note the difference in impact for those 2 countries in deaths https://t.co/9Y4io9tZwo
2022-06-11 15:36:57 RT @stevenbjohnson: “The narrative has been incubating for many years, but in recent days we are witnessing some extraordinary progress in…
2022-06-11 14:31:37 If you're looking for some very upbeat biomedical stuff, here it ishttps://t.co/uM9vNKj53D…Including the first time immunotherapy alone eliminated the need for chemotherapy, radiation and surgery
2022-06-10 23:20:56 @EagleMD3 Much appreciated
2022-06-10 23:04:56 @cocodoxy Thank you!
2022-06-10 22:49:00 I wrote about a cluster of new individualized medicine reports for cancer that are noteworthyhttps://t.co/uM9vNK1tF3
2022-06-10 16:49:47 Science communication during public health criseshttps://t.co/GxdFO841cI @Clin_Chem_AACC @_AACC w/ @hholdenthorp @apoorva_nyc @jsross119 @dicktofel @ClinChemJoe https://t.co/AQRp5J9qi5
2022-06-10 15:46:49 The Omicron subvariant wave (particularly BA.4/5) is starting to emerge in the UK and the implications are nicely summarized in this https://t.co/Zymh4BqGOK
2022-06-09 23:14:12 In case you are not familiar with the nuclear pore complex, it is in every cell of your body (that has a nucleus), comprised of >
2022-06-09 22:25:42 More NPC stuffhttps://t.co/Cyq6RGfpFfhttps://t.co/JTYzbbvXM9 https://t.co/opADCCIpeO
2022-06-09 22:21:43 At @TheEconomist, a great overview on foundation models, an exciting, rapidly evolving frontier in #AI. Best line:"True, foundation models are capable of behaving like an idiot, but then humans are, too."https://t.co/HK0FYbahd4https://t.co/eqdvWTbdD9 https://t.co/xvMrwX7uuh
2022-06-09 20:33:28 Enough with the mice. We need this for peoplehttps://t.co/1fxeOGzBKdPerformed better than intramuscular shots@PNASNews https://t.co/CyJ4moUxRx
2022-06-09 18:49:31 Extraordinary work and perseverance by multiple groupshttps://t.co/rzi5w0CcbFThis wouldn't have happened without #AI #AlphaFold https://t.co/Gq8supfKRv
2022-06-09 18:33:39 Today is a BFD triumph in life science—solving the 3D structure at near atomic level resolution, one of the world's hardest, giant jigsaw puzzles—the nuclear pore complex—the largest molecular machine in human cells, with structure-based AI prediction @ScienceMagazine https://t.co/k2B91KOr8B
2022-06-09 16:01:53 We've chronically undervalued the importance of diet for promoting &
2022-06-09 15:34:43 With all we've learned in recent years about the gut #microbiome, what is healthy eating now?https://t.co/ashCdpiVzp A tour de force review @cellhostmicrobe https://t.co/beTCzbUj2P
2022-06-09 15:24:43 The BA.4/5 variants, the next chapter of the pandemic in the US and Europe, is a story of immune escape, nicely characterized in this new @CellCellPress paperhttps://t.co/1aCfzw6ivO https://t.co/mhA87niphU
2022-06-09 13:33:50 Nationwide England data (57 million people) for the 1st 2 waves of the pandemic and the risk of immune-mediated diseases/medications used to treathttps://t.co/8slzQXGuHm @LancetDigitalH https://t.co/AJ4rLMOpaL @TheLancetRheum https://t.co/1ECfsRHGYz
2022-06-09 12:40:11 Ahem. Over 210,000 confirmed new cases yesterday (= well over a million real ones) https://t.co/krzSvEkEI2
2022-06-09 01:37:31 If you prefer event curves https://t.co/BKaeneXmnU
2022-06-09 01:37:30 New @NatureMedicineGood to see @KPSCalResearch, large health systemOmicron BA.1, BA.1.1, BA.2 infections had far less unfavorable outcomes than Delta, *adjusted*, ~40% less hospitalization, ~80% less death (vaxx or no vaxx)https://t.co/dYwYnzTu0r https://t.co/T0snElzTxO
2022-06-08 23:31:42 The march of the Omicron subvariants will prolong the current wave, which is the highest case burden except during Omicron BA.1 in the US pandemic, adjusted for lack of central/PCR testing https://t.co/oeV2d8JkIL
2022-06-08 23:18:38 A simplified mutation map of the changes in the spike protein for the US Omicron subvariant wave https://t.co/JlIP7KuUFf
2022-06-08 22:47:35 Omicron subvariants response to monoclonal antibodies: more immune escapeTable (lower number, more sensitivity) vs BA.2BA.4/5: ~20-fold more resistant to Evusheld(on path to US dominant)BA.2.12.1: 4-fold more resistant (now dominant in US)https://t.co/cULie0sU8H https://t.co/4EmKghcz7l
2022-06-08 21:04:40 "Our results underscore the potential importance of selective pressures such as the use of monoclonal antibodies — in combination with the lack of an effective endogenous immune response--in promoting escape mutations"https://t.co/Gtzmv6y3AN in 5 immunocompromised patients @NEJM https://t.co/veGpi3Vhhr
2022-06-08 18:10:03 They're still increasing during the current US Omicron subvariant wave, but at least the rate of rise is slowing@OurWorldInData https://t.co/HrYFvqV25B
2022-06-08 17:43:26 Challenging dogma:When mutations don't change the amino acid (synonymous) but alter the fitness of the protein, and can be as harmful as non-synonymous mutationshttps://t.co/zEQahjDhw0https://t.co/WUUNNgVB7E@Nature @NatureNV https://t.co/FuTMt9ChWH
2022-06-08 17:29:02 An exceptional #LongCovid thread by @trishgreenhalgh https://t.co/w1o2qNfJoa
2022-06-08 15:56:12 When #CovidisAirborne at a Nurses Station during a hospital outbreakhttps://t.co/2MEqNA6ZlU @JAMANetworkOpen https://t.co/8ycndJ08PL
2022-06-08 15:33:24 More evidence of #SARSCoV2 viral reservoir in some patients with #LongCovid "the presence of residual virus within the appendix and breast tissue of 2 patients who exhibited LC symptoms"https://t.co/bc36mOGyxd https://t.co/V4nC8NzqEM
2022-06-08 15:13:40 And the 1st onehttps://t.co/TKtZSpSuef
2022-06-08 04:00:31 @GetOffMyLawnPod That there's potential that Paxlovid might not work very well in the future
2022-06-08 03:45:43 High level Paxlovid resistance (up to 80-fold) can be created in lab w/ highfitness2 reports replicate (mutations L50F, E166V/A, +/- L167F)https://t.co/EoLVXLRcKhhttps://t.co/FTyE4RP8yRSupports need for genomic surveillance + development of more potent oral anti-viral pills https://t.co/s3Azsw97Tb
2022-06-08 01:15:01 more Covid in Florida https://t.co/1rYT5tf2XW
2022-06-07 23:03:11 Reduction of severe Covid increased when Evusheld given early, and present/similar magnitude across nearly all subgroups https://t.co/MbtUtdXhTq
2022-06-07 22:56:27 @LancetRespirMed A randomized trial of Evusheld vs placebo reduced severe Covid, from 9% to 4%, among 910 participants (RRR 50.5%). Previously Evusheld had proven efficacy for prevention in immunocompromised
2022-06-07 21:26:23 Covid in Florida https://t.co/bVTQ2CQmW6
2022-06-07 21:07:01 @JeffBlackham @FryRsquared Agree!Important data point @FryRsquared reviewed for chemotherapy after breast cancer surgery in 100 women. How many does it actually benefit? 5 https://t.co/IcsLqVxwVt
2022-06-07 19:52:36 As predicted, FDA Advisory Committee votes 21-0 today to recommend @Novavax EUA
2022-06-07 19:33:32 RT @virusninja: This study is one of the few that benchmarks the host response to #SARSCoV2 against #flu. This enables us to define what m…
2022-06-07 18:51:25 That's right.https://t.co/OUwlOKLlkq by @henryimiller @GeneticLiteracy
2022-06-07 18:27:24 Not every day there's an anti-obesity drug that leads to 15-20% body weight loss https://t.co/5jiUjsV5nB recently @US_FDA approved for #diabetes treatmenthttps://t.co/o3gMtSrkeG https://t.co/bWpb9BA5TJ
2022-06-07 17:36:21 "A once-in decades opportunity now exists"New @JAMA_current accompanying the @CDCgov reporthttps://t.co/vuF9Y0FFhn via @chrishendel https://t.co/4nJmrjNx65
2022-06-07 17:01:39 "Ventilation is a key strategy recommended to reduce COVID-19 spread in school settings" —new @CDCMMWR reportSo why aren't we doing that everywhere?https://t.co/mkhKpV9PGL #COVIDisAirborne https://t.co/vA150WKy0n
2022-06-07 16:59:45 @EcoSexuality Hopefully, if the L452 mutation is key, and shared by these 3 variants (BA.2.12.1, BA.4, BA.5)
2022-06-07 16:09:57 Olfactory bulb (comparison with influenza) and transcriptomics of peripheral organs https://t.co/vFWJeTYE9M
2022-06-07 15:44:23 New, important #LongCovid report @ScienceTM: persistent pro-inflammatory biology"These data highlight a molecular mechanism for persistent COVID-19 symptomatology and provide a small animal model to explore future therapeutics."https://t.co/iLQ8dTw8BA @Justin_Frere @virusninja https://t.co/sheH9B5W4v
2022-06-07 15:12:07 "So drink up--but it would be prudent to avoid too many caramel macchiatos while more evidence brews." Excellent editorial succinctly reviews all the data on coffee and outcomes, by @wee_christina https://t.co/olLFERsRmN https://t.co/RE8R9RDjGt
2022-06-07 15:03:17 The @AnnalsofIM studyhttps://t.co/NmTg0F3xzu https://t.co/jiqV3fQ3H4
2022-06-07 15:03:16 For lovers, good news (with the usual caveats of observational studies, as highlighted below)https://t.co/eCK4bzwuo2 https://t.co/8gI2nXn8Py
2022-06-07 14:48:38 ->
2022-06-07 00:15:11 Mass shootings in the US—2022, thru June 5, 246—2021 year, 240https://t.co/DcI1cKrbeT@juledurg @dataKateR https://t.co/C2A031RGhS
2022-06-06 23:40:43 @CarlosdelRio7 @AnnalsofIM Many were not
2022-06-06 21:35:18 RT @JamesSurowiecki: "But, of course, CDC can't provide the data" is such a sad, and true, sentence.
2022-06-06 21:33:03 When the primary efficacy metric is low, you go on a hunt for more:"This secondary analysis of the ... trial sought to identify other potential clinical benefits of molnupiravir versus placebo@AnnalsofIM 1° results https://t.co/MC2XwTek8V2° resultshttps://t.co/NNTfy1H5QZ https://t.co/ezTnbNVa7k
2022-06-06 20:25:30 A look at who is getting hospitalized in the US during the BA.2/BA.2.12.1 wave.>
2022-06-06 19:59:32 Maternal asthma and the risk of children with asthmaEvidence for an epigenetically mediated mechanism during in utero exposure https://t.co/OgVfgEjJyN @PNASNews https://t.co/UFGjIzl7pQ
2022-06-06 18:00:02 BA.4 and BA.5 have different mutations than BA.2.12.1 in the spike protein and other parts of the virus (nucleocapsid, ORFs) as shown herehttps://t.co/0dcenIjbZ6 https://t.co/cKewJ8ADrw
2022-06-06 16:16:50 Typo: BA.4/BA.5 more immune evasiveness than BA.2.12.1.....
2022-06-06 16:13:03 The graph at the left is weeks behind. On the right, from Minnesota's twin cities, is where we are headed. BA.4/BA.5 has more immune evasiveness than BA.1.12.1, more transmissibility, and more pathogenic in the lab and experimental model https://t.co/x2K0UT1Tqg https://t.co/JhD6Fhbhe8
2022-06-06 14:45:43 4th shot datahttps://t.co/W4xkPskVdP
2022-06-06 14:40:55 @RyanCartwright @joshulick yes
2022-06-06 14:34:15 Following one of the worst 1st booster shot uptakes in the world among developed countries, of more than 112 million Americans age 50+, only ~5 million have had a 2nd booster shothttps://t.co/9u80GJOkQl by @joshulick https://t.co/hyDGbbBMDc
2022-06-06 14:21:11 "The coronavirus pandemic has created a mass-disabling event" #LongCovid https://t.co/0urhgtH3zZby @FrancesSSellers
2022-06-06 01:09:20 RT @macroliter: @EricTopol @LizSzabo Yup. I’m quite concerned that 3x mRNA vaccinated folks like me who’ve thus far managed to avoid contra…
2022-06-05 17:51:53 'A complete remission in every single patient is “unheard-of”'Combining genomics diagnosis of mismatch repair deficient + PD-1 immunotherapy led to complete remission of 18 consecutive patients w/ advanced colorectal cancer https://t.co/54yFGoTDoZhttps://t.co/CZsoFHM0Gl #ASCO22 https://t.co/Lqtlir8Nr3
2022-06-05 16:56:49 @moskov Because the have the same spike sequenceThey differ in other parts of the virus https://t.co/92rCNiT9f2
2022-06-05 16:26:55 It's not over, by any means, but the chances of dying from Covid keep declining https://t.co/6Bl6ULPeey
2022-06-05 15:58:18 In case you were wondering if BA.4/5 will outcompete BA.2.12.1, and more.... https://t.co/7Lv7kAyD3j
2022-06-04 16:04:05 6 cases of myocarditis, all recovered, no other safety concernsData clearly meet criteria for EUA and many people have been waiting for a non-mRNA alternative for primary vax or booster https://t.co/tYCbGgCjv1
2022-06-04 16:04:03 The @Novavax vaccine @US_FDA documentshttps://t.co/QZHMRa0N9eGood efficacy (pre-Omicron) vs all infections https://t.co/pzrNwjCRBa
2022-06-04 15:36:13 A distinct post-Covid phenotype with smell and taste dysfunction is associated with better recovery #LongCovid "This stresses the heterogeneity of post-acute Covid sequelae, each requiring tailored management strategies"https://t.co/nTfTMjTjui https://t.co/fz8xaR80te
2022-06-04 15:11:07 A randomized trial in patients with colon cancer demonstrates the benefit of liquid biopsy to markedly reduce chemotherapyWhen "biology outperforms anatomy to improve therapy"https://t.co/gd0vVevqJX #ASCO22https://t.co/D7M1osPXWw https://t.co/6xNTDhuYB1
2022-06-04 14:56:42 The "S" word for the pandemic is subvariants. Who even heard or used this word prior to Omicron's descendants? 6 weeks ago the US was in the best shape since it all started. Then came BA.2, now BA.2.12.1, and next up BA.4, BA.5. https://t.co/CwdlEZMdWJ
2022-06-03 19:18:29 @larrybrilliant Thanks Larry. Wish it could be more optimistic
2022-06-03 17:59:53 Our immune system follows circadian rhythm. A new review @SciImmunology. And why getting Covid vaccines in the morning elicits a better antibody and cellular immune responsehttps://t.co/nqDxy3XYv1 @ScheiermannLab https://t.co/qfmkX4kQ4g
2022-06-03 17:31:43 Confirms and extends prior summaryhttps://t.co/d7VsfmoKYb
2022-06-03 17:01:05 New @CDCMMWR on #Monkeypoxhttps://t.co/h9lI3IHt2o https://t.co/aecCLiOHJ2
2022-06-03 15:56:32 Just out @SciImmunology Post-vaccination breakthrough infections with Omicron BA.1 provide strong neutralizing activity vs BA.2 (and prior variants) but not vs BA.4/5https://t.co/EyBy7aaEps https://t.co/RYhIAwUHj5
2022-06-03 14:51:58 From my book Deep Medicine https://t.co/GLk8mic7LH
2022-06-03 14:43:52 Human touch is irreplaceable. https://t.co/yarGl5vo2K
2022-06-03 14:27:52 A 59 % higher risk of developing diabetes in post-acute COVID-19 phase versus healthy controls, from pooled analysis from 4 large retrospective studies #LongCovidhttps://t.co/l0MtYPgbRO https://t.co/fcqNQUuA9b
2022-06-03 04:37:31 7% reduction in cases, week-to-week https://t.co/QPRo6jaOkaI'm certainly not convinced it's peaked, but I never give up hope. And know there will likely be BA.4/5 to contend with and known unknown variants ahead. https://t.co/mhAD8MbYOL
2022-06-03 04:04:39 Could the US BA.2/BA2.12.1 wave have peaked?Hard to know with under-reporting/lack of testing and many regions still in flux, but let's hope it's a good sign https://t.co/PA3FpMKeSI
2022-06-02 23:33:35 On a related front, Turbocharging the T cells to fight cancer https://t.co/2Gsq6B27jQ https://t.co/CvJBSiFG4u
2022-06-02 18:57:05 "Height may be an unrecognized but biologically plausible risk factor for several common conditions in adults" @PLOSGenetics https://t.co/c0rmnf91RMTall stature associated w/ protection vs atrial fibrillation, cardiovascular conditions but heightened risk (no pun) for others https://t.co/JtaTAQIvj0
2022-06-02 18:01:58 Nothing to see or do anything about hereBecause we've capitulatedhttps://t.co/N5zk6WaGIt https://t.co/feorbboflJ https://t.co/6DiTkGYpvG
2022-06-02 17:58:11 With the US now BA.2.12.1 variant dominant, yesterday there were over 263,000 new confirmed cases reported and 1,247 more people hospitalized for Covidhttps://t.co/QPRo6jaOka
2022-06-02 17:40:50 This may be the 1st report of the liquid biopsy biomarker result predicting immunotherapy response better than a solid (tumor) biopsyhttps://t.co/CahP0OUYDI #cancer @TischCancer @MountSinaiNYC @ChristianRolfo https://t.co/CWxpBKmkRK
2022-06-02 16:53:01 What was the impact of Covid vaccine mandates for increased uptake across multiple countries?A big range, from <
2022-06-02 16:45:28 Correction: autoimmune diseases (IBD, MS, SLE, RA, PSS, etc) and heart disease
2022-06-02 16:41:19 You'll be seeing a lot more of these headlines, not just for infectious diseases, but also for cancer, autoimmune heart disease, and genetic disordershttps://t.co/SDfsw4g30KMy substack review of this exciting path forwardhttps://t.co/KoEDkEsYrb https://t.co/nTmcL5T2DH
2022-06-02 01:19:20 Even with the common rebound issue, it really turned out to be a just-in-time breakthrough, as I wrote about ~6 months agohttps://t.co/lcAtZU4RJW
2022-06-01 22:25:17 More symptoms, disruption with BA.2 than BA.1https://t.co/eTDXmumK7wReinforces: as the virus evolve, it doesn't necessarily become less virulent
2022-06-01 22:25:16 Recently, worse symptoms from BA.2 infections have been documented compared with BA.1below. A new report shows the BA.2 variant replicates more efficiently in the upper airway and lung compared with BA.1https://t.co/GQdm0hJ65w @hkumed https://t.co/g6DzDe0hta
2022-06-01 22:07:58 Accompanying editorial. helpful context, significancehttps://t.co/3JUN43GH8h by @CMelief https://t.co/N5Z6bOIUIp
2022-06-01 21:04:30 It's a @NEJM case report, but a groundbreaking one. For a woman with refractory pancreatic cancer, genetically engineered T cells directed towards the KRAS driver mutation achieved substantial tumor regressionhttps://t.co/X7NuoRehtq https://t.co/TsGg84GzHa
2022-06-01 20:00:44 A new real-world effectiveness report of Paxlovid during the Omicron wave: in people age 65+ an 81% reduction in death and 67% reduction in hospitalizationshttps://t.co/ZNohKWmTK6@ArbelRonen @ClalitHealth and colleagues https://t.co/MbakbgkbAJ
2022-06-01 18:14:59 The overall sensitivity of Covid detection by trained dogs was 97% and "even reached 100% in asymptomatic individuals" compared to nasopharyngeal swab PCR tests. Overall canine sensitivity vs PCR (97% CI: 91 to 99 versus 84% CI: 74 to 90, p = 0.006), https://t.co/tE2oD6Ecdf https://t.co/uC9hDTH9WM
2022-06-01 17:16:25 The mutations our blood cells acquire as we age—clonal hematopoiesis—is the norm, 10% of blood cells for age 70+, with marked reduction of diversity
2022-06-01 14:41:31 A1 and other useful graphs, data https://t.co/AXEknMTPZs
2022-06-01 14:41:29 Yes, the marked increase in transmissibility of Omicron over Delta was a driving factor. But vaccinations in age 65+ during Omicron were critical: 2-shots reduced deaths by 85% and with a booster there were 96% less deaths https://t.co/8jL05VYudb
2022-06-01 13:52:14 Our brain's impressive immune defense systemhttps://t.co/RSNmd230Xm@Nature feature by @DianaMKwon https://t.co/FYGBuOFM0c
2022-06-01 13:47:33 A black market for Covid anti-viral pills, the Molnupiravir experience https://t.co/zzCOKZnf2u @bmj_latest https://t.co/IT6FuMy1rM
2022-06-01 02:37:53 A new @bmj_latest systematic review of 53 studies of boosters and mix and match shows marked benefit of boosters but little difference for mixing (mRNA and adenovirus) vs matching (3 mRNAs)https://t.co/QsoBUwyIhx https://t.co/euWoXj3ul8
2022-06-01 02:03:27 And is dominant (>
2022-06-01 02:03:26 The BA.2.12.1 variant is now 59% [95% CI 55,63%] of new cases in the United Stateshttps://t.co/jjl2AnwOWX(It's ~25% more transmissible than BA.2, which it out-competed) https://t.co/S6Uo7GscDh
2022-06-01 01:53:57 Publsihed today @PNASNews Mask wearing significantly reduces #SARSCoV2 community transmission. Analysis of the effect in 92 regions, 6 continents https://t.co/t9lD0KYvTt by @g_leech_ and colleagues https://t.co/I6HxL5fSR0
2022-05-31 22:31:01 Is it time to do systematic medical real-world reviews with #AI support to promote accuracy and reduce bias?https://t.co/Mua9o8tspe@AnnalsofIM @AnnelieseArno @jhjelliott https://t.co/gQE4vkhnIL
2022-05-31 18:52:33 Quite a feat:"We report the transplantation of a human liver discarded by all centers, which could be preserved for several days using ex situ normothermic machine perfusion."https://t.co/TQuXIh0ie3@NatureBiotech
2022-05-31 16:59:18 "As of mid-May, more than one-quarter of Americans 65 and older had not had their most recent vaccine dose within a year. And more than half of people in that age group had not been given a shot in the last six months." https://t.co/s2iDznH0x8
2022-05-31 16:27:43 Omicron's lethality rate among seniors was worse than Deltahttps://t.co/DqZooPJKvaThe waning of vaccinations, lack of adequate booster uptake in this high-risk age group were contributory factors
2022-05-31 16:17:14 @CT_Bergstrom @JAMANetworkOpen In agreement. Here are the other graphs from their report. The other issue is pitting models vs doctors when that is not the real world for how medical decisions/prognosis are determined https://t.co/kg8TpWXeOU
2022-05-31 15:34:23 When the machines outperformed 74 oncologists for predicting outcomes in a prospective study of over 2,000 patients with advanced cancer #AIhttps://t.co/UmfjRhZak2 @JAMANetworkOpen https://t.co/5zJSb0qv0g
2022-05-31 15:23:18 "Our findings suggest that even in the context of airborne transmission, approximately 4% of index [Covid] cases in indoor settings would account for 80% of secondary cases"A new analysis of superspreader events and overdispersionhttps://t.co/OsTuZfJHPU
2022-05-31 15:12:13 Pulse oximetry overestimates arterial oxygen saturation in racial minority groups with Covid, leading to lack or delay of therapies. This "occult hypoxemia" may worsen outcomeshttps://t.co/fc9FRQUx1k @JAMAInternalMed https://t.co/QzKwVGwZjh
2022-05-31 14:03:27 Over 2 billion doses of mRNA + nanoparticles has laid the foundation for a new approach to infectious and autoimmune diseases, cancer, genetic disorders, and prevention of heart attackshttps://t.co/KoEDkEsYrb
2022-05-31 02:44:18 Progressively taking the death out of the Covid calculus, now 90% reduced from peak worldwide@OurWorldInData https://t.co/GNBRK6gMyC
2022-05-31 01:05:13 Quite the lede"The isolation of CCoV-HuPn-2018 from a child respiratory swab indicates that more coronaviruses are spilling over to humans than previously appreciated."https://t.co/GmUA4P289i @CellCellPress by @veeslerlab https://t.co/RqZd6e9NL4
2022-05-31 00:39:23 RT @gabrieldane: Happening tomorrow, 7p ET. Let’s BLOW THIS UP #medtwitter. Let’s show we can focus our collective energy on making a dent…
2022-05-30 21:36:13 A look at the bright side of the pandemic for decades to comehttps://t.co/KoEDkEsYrb
2022-05-30 17:34:19 "Our study reveals how specific neuron clusters located in diverse regions of the brain relevant to fear and the fight or flight response cause massive changes in leukocyte distribution and function"Elegant work w/ #optogenetics @WolframPoller @IcahnMountSinai @SinaiHeartBlood
2022-05-30 17:27:54 With a great resource that summarizes all the mutations that have changed amino acids and led to impact, with references https://t.co/5WtVC43zvz
2022-05-30 17:15:21 @NatureMedicine "The pandemic is not over, and #SARSCoV2 is spreading at a high level globally. Now is the time to enhance global sequencing capacities, focusing on widening coverage to include previous geographical and population blind spots"https://t.co/yL2xisDH0r@lsubissi https://t.co/xip3MR762v
2022-05-30 16:22:17 Just published @Nature How acute stress impairs our immunity to Covidhttps://t.co/dmI0FgzoOV https://t.co/ru5xh26Yjb
2022-05-30 15:51:29 Covers @NewYorker by Eric Drookerpaired withhttps://t.co/z04JguVmPL by @jelani9 https://t.co/zlwl0Q1CZ9 by @rachmonroe https://t.co/N74IKbf1ZO by @winterjessica https://t.co/l2yXqQdHXx by @JohnCassidy https://t.co/uUGMGn3nAa
2022-05-30 15:33:02 RT @ChasBeekeeper: @EricTopol @AditGinde That’s reassuring and I’m so grateful for having received Evusheld in February. Without additional…
2022-05-30 15:25:37 For the pandemic, "U.S. deaths were 15 percent above normal — a number surpassed by only four other large countries in the same income group: Chile, the Czech Republic, Poland and Romania."https://t.co/mRvXoGktRd @DeniseDSLu @nytgraphics https://t.co/rShmir7w0g
2022-05-30 15:11:09 Paxlovid became a household name in the US during the BA.2 waveDuring the week that ended May 6, prescribers wrote 8,977 scripts of Lagevrio (Molnupiravar) and 118,123 scripts of Paxlovidhttps://t.co/bkCwy9p6kL by @JaredSHopkins
2022-05-30 15:05:41 A bad case :-)by @speedbumpcomic https://t.co/FzkBfRump5
2022-05-30 01:41:34 RT @Bob_Wachter: We’ve been counting on Evusheld to remain a key tool for protecting immunosuppressed people during Omicron. Ir wasn’t a sl…
2022-05-29 21:40:28 First real-world assessment of Evusheld protection for immunompromised people during the Omicron wave:Marked reduction of mortality, hospitalization and infectionshttps://t.co/q59gyiInui @AditGinde https://t.co/zvpGL97JOX
2022-05-29 18:39:28 If you're looking for some inspiration, look no further than @jacindaardern's commencement addresshttps://t.co/I8GJCklHKx)
2022-05-29 17:50:07 https://t.co/9BEj4Ns973
2022-05-29 17:38:54 RT @ACPinternists: How can we address #priorauth and the burden it puts on physicians/patients? On 5/31, join ACP &
2022-05-29 17:32:00 Graph via @trvrb https://t.co/1Fc9uytdv4 https://t.co/L6YKTLHPok
2022-05-29 17:31:59 Updating, one year laterOriginal: https://t.co/xec3OdHiFV @CellCellPress by @K_G_Andersen and colleagues https://t.co/8Kt6rDfx7E
2022-05-29 15:23:36 "compel us to take bold action" --@aboutKPSay it: Ban assault weapons. And much more https://t.co/OF43dV9NvO
2022-05-29 15:18:05 "We could have more Warp Speeds — for therapeutics, for ventilation systems, for rapid global provision of vaccine technology."https://t.co/v54dznAqUF by @dwallacewells @nytopinion https://t.co/KxlIHrmYtZ
2022-05-29 15:10:06 That's right. Thanks @aboutKP https://t.co/JEUyY3jd8q
2022-05-29 02:02:01 I attempted to make a graph to highlight this point of *intrinsic* virulence increasing up to 3 times via diff't (sub)variants during the pandemic, which has been misinterpreted. The point is made below w/data above and the graph has been deleted. https://t.co/eZmw5hAVOa
2022-05-29 01:40:38 @socalsysbio There is confounding of vaccination and prior infection. Adjusting for that, Omicron was thought to be ~25% less virulent than Delta. Subsequent studies for BA.2 and BA.4/5 are summarized in the
2022-05-28 22:41:54 The progression of the virus's fitness throughout the pandemic. Fitness encompasses a lineage's growth, Ro reproduction number, immune-evasiveness and generation time. Graph doesn't include BA.2.12.1 and BA.4/5 which are more fit than BA.2https://t.co/0WY7gW3RtB https://t.co/gKvvyYbMOO
2022-05-28 22:14:04 The US current BA.2/BA.2.12.1 wave may be extended by the BA.4/5 variants, owing to their growth advantage and higher fitness, as aptly reviewed here https://t.co/1Fc9uytdv4
2022-05-28 20:14:35 "Odds of infection for those who did not always compared to those who always wore a mask was 66% higher pre-Delta, 53% higher during Delta, declining to 16% higher during Omicron"https://t.co/mXBde7wn6AOmicron's hyper-transmissibility necessitates high- quality masks (KN95/N95) https://t.co/CEtUmz5lXM
2022-05-28 16:49:44 Two countries where the BA.4/BA.5 variants became dominant: the outcomes are quite different@OurWorldInData (Not so easy to extrapolate impact of variants across places w/ marked differences in population demographics, prior/strain of infections, vaccinations, testing, etc) https://t.co/tgfHVsR3qY
2022-05-28 16:26:53 The current BA.2/BA2.12.1 wave is the 2nd highest case burden for the US pandemic
2022-05-28 16:17:41 The immune response induced by Omicron post-vaccination breakthrough infections is blunted compared with Delta breakthrough infections https://t.co/Bf5oDUKWvh @ImmunityCP @MariosKoutsakos @TheDohertyInst @ProfStephenKent and colleagues https://t.co/yWvbd4u3oY
2022-05-28 15:57:39 Prior Covid, unvaccinated, offers limited protection from Omicron infections in contrast with 3-dose vaccination: new report from the California prison system during Omicron wave of ~25,000 cases and >
2022-05-27 20:27:04 "BA.4 and BA.2.12.1 can overcome immunity provided by earlier infections with other Omicron subvariants." "This was unexpected...maybe we should adapt the system of naming"—@houzhouhttps://t.co/D0Ce1VPmsj @Nature by @amymaxmen
2022-05-27 19:56:34 @trvrb @LongDesertTrain @calmarten I provided the source in the threadhttps://t.co/IKqSKtzdR6 which did include the antigenic map below, conveying the same point as the genetic distance, but may be more difficult to interpret for people not familiar with the mutations https://t.co/IgS0piAXdr
2022-05-27 17:56:42 —BA.2 more symptoms than BA.1 https://t.co/eTDXmumK7w—BA.2.12.1 and BA.4/5 more replication in lung cells than BA.2—BA.4/5 more pathogenic than BA.2 in exp'tl modelhttps://t.co/TvwlO8ljPJ—BA.4/5 more immune escape than BA.2.12.1https://t.co/IKqSKtzdR6
2022-05-27 17:27:20 Keep your eyes on theevolutionThe antigenic distance (how our immune system "sees" the virus) from Omicron BA.1 to BA.2.12.1 (the dominant variant is the US now) and to BA.4/5 is pronounced. Note no functional sub-variants of any prior Greek letter VoCs https://t.co/Q2BTBI2OUJ
2022-05-27 17:00:15 + ThisFederal assault gun ban expired in 2004#ThisIsOurLane @ThisIsOurLane https://t.co/yl5qbH49bx
2022-05-27 15:15:20 https://t.co/GMsglbBvqW
2022-05-27 14:40:04 Or this https://t.co/o3HqIBGndQ
2022-05-27 14:06:35 @mroliverbarnes @FT Thanks for your indefatigable work covering the pandemic!
2022-05-27 13:32:29 .@HHMINEWS https://t.co/VpYawj2qe3 by @laurenmlumpkin https://t.co/LgbZh3kTtt
2022-05-27 13:24:35 And this https://t.co/YKheISjYVe
2022-05-27 13:24:34 This https://t.co/gLd1tQ7raq
2022-05-27 12:51:57 RT @trishgreenhalgh: This is causing waves among virology Twitter. Bottom line: the pandemic is not over, and it's NOT getting milder.
2022-05-27 12:42:09 RT @Noahpinion: Yes we are
2022-05-27 03:55:04 "The United States has 46 percent of the world’s civilian-owned guns "https://t.co/Hf7fTQoRS3That was as of 2018, and has increased since then
2022-05-27 03:50:47 Confirmed Covid deaths, as of todayUS 1,004,121World 6,284,446https://t.co/gV8kcaeLPK
2022-05-27 03:27:30 American exceptionalismThe United States comprises 4% of the world's population 16% of the world's Covid confirmed deaths 40% of world's guns Only industrialized nation in the world with states making abortion illegal
2022-05-27 02:38:45 @TenTenbrink Thank you!
2022-05-27 02:36:05 Table of the 7 casesThe Omicron high viral load issue, as opposed to Delta when the Paxlovid randomized trials were conducted, may well be the driver of this rebound https://t.co/QGWCtff3sy
2022-05-27 02:33:01 @violetblue Thanks, Violet. I had missed this, completely unacceptable and fulfills your WTF label
2022-05-27 02:29:37 RT @gmleunghku: Thanks @EricTopol for shoutout…I’ve put together a thread here to explain in a little more detail about this and another re…
2022-05-27 02:27:42 Paxlovid relapse insights from 7 individualsHigh viral loads at enrollment and for 17 days
2022-05-27 02:01:54 1st report of real-world effectiveness of Paxlovid in the outpatient setting, BA.2 wave, Hong Kong75% reduced death, 31% reduced hospitalization, 53% reduced adverse outcomesNo impact of vaccination on outcomes
2022-05-26 23:33:48 @antoniottwalter @SystemsVirology More than prevalent. BA.2.12.1 is dominant in the US
2022-05-26 23:26:16 Above is the 2nd example of a new variant (BA.2) being more virulent than a predecessor (BA.1)The first was Delta over AlphaNew data today suggests the Omicron subvariants (BA.4/5, BA.2.12.1) may have more virulence than BA.2
2022-05-26 23:20:02 BA.2.12.1 and BA.4/BA.5 characterized in human lung cells and an experimental model by @SystemsVirology —All 3 Omicron subvariants have enhanced replication in lung cells compared w/ BA.2—BA.4/5 is more pathogenic than BA.2 in animal modelhttps://t.co/TvwlO8ljPJ https://t.co/gSwzPoatg3
2022-05-26 23:09:37 The immune evasion is more extensive for BA.4/5 than BA.2.12.1 variant, raising the possibility that the former can out-compete the latter. Only one clinically available monoclonal antibody (bebtelovimab) has full potency against these Omicron subvariantshttps://t.co/IKqSKtzdR6 https://t.co/6RWSGiGtjw
2022-05-26 19:55:14 @hholdenthorp @juliettekayyem @meghas I could have highlighted every word.Thanks Holden https://t.co/rccOheCQeB
2022-05-26 18:10:35 A smorgasbord of outstanding reviews and perspectives on the human microbiome in the new issue of @ScienceMagazinehttps://t.co/Y67TpxzTm5 https://t.co/79q041Tcfz
2022-05-26 18:06:35 The first dissolving pacemaker with a wireless body network for smartphone physiologic vital sign monitoring and real-time patient haptic feedback, on a temporary basis@ScienceMagazine https://t.co/nWtVpvIhyehttps://t.co/ZIzgQkT3Do https://t.co/9FhHSc0LWq
2022-05-26 14:38:22 Head-to-head comparison of immune response, both antibody and cellular, for 4 vaccines: Moderna, Pfizer, Novavax and J&
2022-05-26 14:03:55 "Affinity Escape"Another potential mechanism for #SARSCoV2 immune escape: if a variant has stronger binding to ACE2, it could compete with neutralizing antibodieshttps://t.co/O9ThYVDjWC
2022-05-26 13:47:41 @CarlosdelRio7 @NatureMedicine @zalaly @BCBowe @Biostayan @WUSTLmed Unclear, but certainly worth finding out if it helps
2022-05-26 13:28:45 https://t.co/Lw5joeipRK
2022-05-26 13:17:31 @ZekeJMiller @ashishkjha https://t.co/QPRo6jaOka https://t.co/eIHYp0P8vl
2022-05-26 12:46:33 @ZekeJMiller @ashishkjha Deaths are rising.
2022-05-26 03:14:04 RT @kaitlancollins: Amerie Jo Garza's father, a med aide, says he found out she was one of the victims when he arrived on the scene and was…
2022-05-26 02:10:25 "Only" >
2022-05-25 23:40:14 The J&
2022-05-25 23:36:49 "BA.4/BA.5 are antigenically distinct from previous Omicron variants, particularly BA.1, and are still at a substantial distance from the closely related BA.2."Breakthrough infections help ->
2022-05-25 21:41:41 OWS 2.0 hasn't happened because "we" gave up, very tired, and pretending this is over—when it isn't. Far from it. https://t.co/N5zk6WsPWB
2022-05-25 21:00:26 During the Delta wave in Israel, the importance of hybrid immunity, a booster shot, or prior Covid for protection from infections. In @NEJM today https://t.co/tDjnmxsnSr@MiloLabWIS @WeizmannScience @TechnionLive @IsraelMOH https://t.co/NxFiLtqP29
2022-05-25 18:48:36 @LSteelback @ScienceTM Thanks for your vote of confidence. We have. All these agencies and the @WHCOVIDResponse want to support but there's this entity called Congress that is blocking it = zero funding
2022-05-25 18:32:05 Operation Warp Speed (OWS)1.0 was one of the most important, life-saving programs in US historyAre we foolish enough not to have an OWS 2.0 to get nasal vaccines, pan-sarbecovirus vaccines, and more/better drugs across the goal line?
2022-05-25 18:27:06 Just about every week there is a new, broad neutralizing antibody (bnAb) discovery, like this one, that is variant-proof and would take down all #SARSCoV2, that vaccines could be made to induce, that we're not advancinghttps://t.co/ektcfd0NEN @ScienceTM https://t.co/01xhPBANj2
2022-05-25 17:19:56 RT @chrischirp: This is a really important paper because it looks at risk of long covid and other post covid impacts (eg on kidneys, heart…
2022-05-25 15:55:56 This graph breaks down the risk of BTI by out-patient or hospitalized/ICU. For the common, non-severe breakthrough infections, the risks are still increased during 6-month follow-up for multiple outcomes https://t.co/rEUNf0GBQ8
2022-05-25 15:00:25 Less risk of #LongCovid sequelae with BTI compared with unvaccinated Covid https://t.co/HcygHmYnRF
2022-05-25 15:00:24 BTI relative risk and absolute excess burden at 6 months for death, particularly increased for clot-related, lung sequelae https://t.co/em3KgnPxoM
2022-05-25 15:00:22 Just out @NatureMedicine The natural history of post-vaccine breakthrough infections (BTI) in 33,000 people, >
2022-05-25 14:21:15 freja kirsebom chrischirp he misclassification explanation for these differences in vs hospitalization seems optimistic without clear data to back it up
2022-05-25 13:32:32 he 2 variant s impact on 3 shot reduced protection vs hospitalization after 3 4 months compared with 1 is noteworthy https t co i jon gix
2022-05-25 13:19:34 xhibit for the people who don t think cases are important https t co 3 nsq y
2022-05-25 13:17:25 o infection of 1 and 2 detected by random sampling underlines the need for effective genomic surveillance to reduce the risk of generating o 2 recombinants with novel pathogenic and immunologic properties https t co n r h https t co e64 lrh73
2022-05-25 13:09:54 he 6th 2 12 1 2 wave esterday s over 140 000 new confirmed cases multiply by 7 for real number gt
2022-05-24 23:39:04 chrischirp his gap is more pronounced than previously reported by and concerning hat are your thoughts
2022-05-24 23:28:27 shley an peechless eartbroken urious 20 years since olumbine27 school shootings so far 14 babies not coming ho
2022-05-24 23:26:35 emmcnally xactly hanks for pointing that out
2022-05-24 23:16:26 able https t co 4y ts k or
2022-05-24 23:16:24 ew he ancet nf is eduction in vaccine booster effectiveness vs hospitalization for 2 vs 1 variants at 10 weeks https t co 6r29aba510 14 wks 70 2 vs 85 415 wks 56 5 vs 80 4 ee table below for 95 and text for detailsby freja kirsebom and colleagues https t co m 0t2js
2022-05-24 23:07:24 clairlemon hat kind of country lets their children be massacred at school
2022-05-24 23:06:19 nd now another heinous catastrophehttps t co gq 0w ym
2022-05-24 17:45:41 verall age breakdown and graphic https t co 6i nn fxf
2022-05-24 17:45:40 new on ong ovid supports its very high frequency and particular associated risks of cardiovascular neurologic respiratory diabetes kidney mental health and musculoskeletal involvementhttps t co l6ch h https t co q d h 9
2022-05-24 16:00:07 uke2315yee tell it like it is hen there s good news will post it f you only want happy talk don t follow me
2022-05-24 15:52:39 2 12 1 now dominant is the 58 of new cases gov https t co x ud4 uaov
2022-05-24 15:32:48 he axis has to be expanded for 2 12 1 and 4 5 and further variants to come
2022-05-24 15:12:31 ith maximal exercise aerosol particle emission increased an average of 132 foldhttps t co s i8 9 1 ews hese data not only explain o 2 transmissions during indoor group exercise but also can be used to design better targeted mitigation measures https t co 2 j5e k
2022-05-24 14:25:04 ust published cience agazine rom analysis of gt
2022-05-24 13:48:31 ontrary to the perception that recent variants have become successively milder micron 2 was associated with reporting more symptoms with greater disruption to daily activities than 1 2 vs 1 igure https t co e mum 7w https t co 01h7din m
2022-05-20 08:11:00 CAFIAC FIX
2022-10-28 19:37:55 Long-lived plasma cells: real time, cell-by-cell time stamping of their immune response after vaccinationhttps://t.co/bKWGL3a5rp half-life of ~700 days in the mouse model @SciImmunology @MonashUni https://t.co/vRFXcnB8Jy
2022-10-28 18:50:00 Billion-dollar experiments to "escape scientific stagnation"https://t.co/t9uGywZXnS https://t.co/fhmXKtENt6
2022-10-28 17:21:41 @uche_blackstock I'm not going anywhere, Uché. That's how I first met you
2022-10-28 17:18:01 @Nate_DiCamillo @CellCellPress unlocking the article https://t.co/8OakGeNT0I
2022-10-28 17:08:59 The case for some vigorous physical activity: association with reduced mortality, heart disease and cancer in ~72,000 people, mean age 63, followed ~6 yearshttps://t.co/h6XY9Cqms4@ESC_Journals @uk_biobank @Matthew_Ahmadi_ @M_Stamatakis https://t.co/pzYJf68EsU
2022-10-28 16:54:42 "Compelling evidence for the role of carboxylic acid in guiding the mosquito's preference toward specific people"https://t.co/wredsoM8ux @CellCellPress https://t.co/EvMS4VES25
2022-10-28 16:32:26 via @chrischirp In England, the share of cases (and spurt) of BQ.1.1 and BQ.1 is similar to the USHospital admissions are currently on the way down (for now at least) https://t.co/FmfnifCxAT
2022-10-28 15:17:45 @ACPinternists @scrippsresearch Thanks @ACPinternists!
2022-10-28 15:15:25 Besides the hopeful sign from France noted yesterday https://t.co/I4ujEQvJgw Region 2 of the US has the highest BQ.1.1/1, particularly New York, where new hospital admits have not shown a recent rise https://t.co/rcWUlpd8dk
2022-10-28 14:55:38 New US Covid genomics: BQ.1.1 and BQ.1 variants now account for 27% of cases, up from 17% a week ago, on a path to be dominant (>
2022-10-27 22:28:59 On a related front, metabolites from a specific gut microbiome bacterium in people with inflammatory bowel disease can promote tumor developmenthttps://t.co/6NNwlJvWmMhttps://t.co/hPXcuOt3ID https://t.co/72VEts7Soa
2022-10-27 22:15:34 Operation Nasal Vaccine. Please.https://t.co/OujfFxMgU6 @SciImmunology https://t.co/CtoZneSx9O
2022-10-27 21:49:26 Thanks to the swientists!https://t.co/YhPoxt6gaO @ScienceMagazine by @sciencecohen https://t.co/N48xJOHv12
2022-10-27 21:47:32 and this https://t.co/RnhEX54VOD
2022-10-27 19:11:59 @CathyLozupone @KristiKuhn @cu_medicine Agree!
2022-10-27 19:06:02 @BenIsraelow Delighted to do so, especially when it's so impressive and gives us much hope for a far better approach/defense
2022-10-27 18:30:09 Protective efficacy of the spike booster lasted for ~4 months, pan-sarbecovirus, using no adjuvants or replication-deficient or live attenuated virus (like FluMist), elicited broad neutralizing Abs.This is the variant-proof booster we need now to help prevent infections &
2022-10-27 18:16:56 Just published @ScienceMagazine A nasal vaccine booster (after primary vaccination) induces mucosal immunity —IgA, memory B and T cell—against the sarbecovirus family in the experimental modelhttps://t.co/j03xNjIXzhby @VirusesImmunity @tianyangmao and team @YaleIBIO @YaleMed https://t.co/M6LQUZWnlc
2022-10-27 17:44:25 RT @MassMedical: .@EricTopol said it would be a mistake to skip these shots. They still work, they just may not be much of an improvement o…
2022-10-27 17:39:01 Very hopeful signFrance is the 1st country in Europe to see the BQ.1.1 variant dominance (>
2022-10-26 21:05:00 The benefit of vaccination and boosters, along with prior Covid, against Omicron infections, in the California prison systemhttps://t.co/VSwHQIkwrD @NEJM https://t.co/3xg2Yn8DBm
2022-10-26 18:42:07 @Alexander_Tin @CNN @US_FDA @moderna_tx The number of participants in each of the 2 bivalent BA.5 booster independent studies is far greater than the ones Pfizer and Moderna have thus presented (zero) and are quite typical for assessment of neutralizing antibody response throughput the pandemic
2022-10-24 01:51:07 That Singapore's XBB variant wave was not severe, with relaxed mitigation, as @Fiona_M_Russell points out, is v encouraging https://t.co/tJuJ82OOBO —XBB's immune evasion could've ->
2022-10-24 01:21:15 @BagaiDr Many thanks Dr, Bagai!
2022-10-23 20:54:45 A booster is your best shot now. Why?https://t.co/G9Gnosk8E8
2022-10-23 18:04:32 It's not a good sign when 3 shots and a breakthrough (BA.1) infection (lower panel) doesn't elicit neutralizing antibodies to some of the new variants (BQ.1.1, XBB, BA.2.75.2) https://t.co/YS9rbTlSGZ
2022-10-23 16:21:46 RT @paula_span: The new bivalent COVID booster: Older folks, a highly vaccinated group, appear less interested in getting it than earlier s…
2022-10-23 16:17:42 @elderconsult I think the likely explanation is a high rate of prior infection, particularly with the Beta variant which seems to provide more cross-immunity than the others
2022-10-22 22:09:29 Thanks for the critique and feedback, @AstroKatie, @choo_ek and many others. A sense of equivalency was never intended. Preventing deaths, hospitalizations and #LongCovid towers over any liabilities.Here's a fixed version https://t.co/hrlYbI8rEI
2022-10-22 20:10:45 For the first year of vaccines, over 20 million lives saved around the world through December 2021 https://t.co/4GnPgEvg7W
2022-10-22 20:10:44 End of July 202291% reduction of deaths, all ages https://t.co/GIPkSo2daH
2022-10-22 20:10:42 Vaccines and boosters save lives. Across all ages.96% reduction of deaths for 2 boosters vs unvaccinatedEnd of May 2022@OurWorldInData https://t.co/UYkn5iszKT
2022-10-22 19:52:45 RT @cshperspectives: Sci comm irony when the first scientist quoted in a story has deleted their twitter account by the time the article ap…
2022-10-22 19:51:15 @JusDayDa @_TheAncientOne_ @MoritzGerstung Yes, that one is good, too. I had summarized it yesterdayhttps://t.co/fS78A4Vrwr
2022-10-22 19:32:01 @JusDayDa @MoritzGerstung Best I've seen is from @yunlong_cao and colleagueshttps://t.co/qWJ4AGtiur
2022-10-22 19:29:06 Avoiding #LongCovidhttps://t.co/VIVNew8bGWMy interview with @maggiemfox @Medscape, video w/ transcript https://t.co/FOpoBMAEOe
2022-10-22 16:59:36 A review of how #AI has been used during the pandemichttps://t.co/tvjS0ifKFE @PLOSDigiHealth "No clinical trials evaluating any applications impact on patient health" by @RANDCorporation @carlberdahl https://t.co/GeoWpysyyj
2022-10-22 15:31:45 The BQ.1.x wave projection for the US, and calculations for many other countries based on growth advantage vs BA.5, by @MoritzGerstung https://t.co/4TozbJWNLa https://t.co/wtuI1qLi4r
2022-10-22 14:15:56 Their XBB wave was projected to exceed BA.5.Strong NPI mitigation practices and very high vaccine/booster uptake (a top 10 country) likely contributed https://t.co/93Vd3T3Qg2
2022-10-22 14:05:17 This is very good news.The XBB variant wave in Singapore is in descenthttps://t.co/mZS5FePzrNXBB and BQ.1.1 are 2 of the most immune evasive variants and Singapore was the first country to experience a wave induced by one of them, now letting up https://t.co/DbkSC4OPN7
2022-10-22 01:27:48 @BMcranty @AstroKatie @Sarcasmorator I don't consider major reduction of deaths, hospitalizations, and #LongCovid as "meh"
2022-10-21 22:51:43 91% reduction of Covid deaths for age 50+ with 2 boosters, August 2022, vs unvaccinated BA.5 wave https://t.co/HGyjNwCm0v https://t.co/VI7LzxaLtM
2022-10-21 22:11:19 @AstroKatie I'm with you. Trying to provide as much balance as possible
2022-10-21 22:08:33 Yesterday's @CDCMMWR report that shows slippage of protection vs hospitalization after 4 months, age 18+, during BA.5 wavehttps://t.co/DRB7tiyffU https://t.co/1bTzbZvhAv
2022-10-21 22:05:10 @Sara43347888 The answer is NO. The @sfchronicle headline is terrible and worse than that is to have it behind a paywall. Unacceptable.
2022-10-21 22:01:41 For ages 18-49, the 72% reduction of Covid hospitalizations with ≥ boosterhttps://t.co/M2Bu9rj1Ve https://t.co/DX8wcxAzzt
2022-10-21 21:48:59 Since Omicron in late 2021, mRNA booster protection vs infections &
2022-10-21 20:53:57 @JohnRossMD That's one of several refutes See @K_G_Andersen https://t.co/HcVEo29XaAAnd @Friedemann1https://t.co/VJCmgWR1Vj
2022-10-21 20:45:55 RT @JohnRossMD: In case you missed it, UK COVID minimizer Francois Balloux has deleted his account after amplifying a spectacularly wrong p…
2022-10-21 18:27:42 RT @JReinerMD: Pfizer projects that it will make $32 billion from its COVID vaccine in 2022 and $22 billion from Paxlovid. Their plan to ch…
2022-10-21 17:41:28 The BQ variants and the UShttps://t.co/KEeCny0P9A by @ErinMPrater @FortuneMagazine
2022-10-21 16:36:27 RT @K_G_Andersen: BQ.1(.1)* picking up steam, but still too low to be making a major difference in cases/hospitalizations - follow this tre…
2022-10-21 15:59:15 That's right—Covid boosters aren't for everyone.But for WSJ to print this seriously flawed claim about cardiac deaths in men age 18-39 is inappropriate, to say the least https://t.co/KCox0mhlHG https://t.co/NixQ2Uki1R
2022-10-21 15:02:26 New lab assessment of these variantsBQ.1.1 has the most immune evasion and fusogenicityhttps://t.co/5FQn5FxOZ1 https://t.co/PmZPkQHB4n
2022-10-21 14:50:01 What are the #SARSCoV2 variants accounting for US cases?New CDC genomic surveillance updateOn the rise: Predominantly BQ.1 and BQ.1.1 (~17%), also BF.7 (7%), BA.2.75.2On the decline: BA.5, BA.4.6https://t.co/jjl2AnwOWX https://t.co/r7i6cYnjSe
2022-10-21 14:37:20 RT @mhornig: Not convinced efforts to avoid #SARSCoV2 infx are worth it? Think #LongCOVID and potential for #MECFS are fantasy? Please list…
2022-10-21 14:20:48 Myalgic encephalomyelitis was first recorded in 1934 in Los Angeles after an outbreak of atypical polio. It has taken nearly a century and #LongCovid to "get needed attention"https://t.co/ryyI15mfnf @NanetteAsimov #mecfs https://t.co/xOYiOk9R2A
2022-10-21 02:54:11 Keep an eye on New York, leading the country with % cases BQ.1.1, bellwether for the next wave https://t.co/vw77IAyHJj (update, first picked up by @JPWeiland) https://t.co/MPJSVvzqEY
2022-10-21 01:50:07 The inversion (next wave) is likely starting by the rise in hospitalizations. Great time for CDC to stop daily tracking https://t.co/RXymG9t41x
2022-10-20 23:56:25 On the imprinting issue, in the Discussion"antibody responses to some Omicron S[spike]-specific epitopes were hindered by prior antigenic exposure" https://t.co/w9oiWH8s5A
2022-10-20 22:39:04 Is the science information credible? For the competent outsider:https://t.co/cuyEKL762s@danrpimentel @ScienceMagazine https://t.co/z8WsB1TOjF
2022-10-20 20:02:03 The mechanism by which time-restricted eating limits obesity (in mice)https://t.co/gENt2Muxtq@DamienLagarde @kazaklab @ScienceMagazine @ScienceVisualsre:https://t.co/DN3oCsON5y@JoeBass91471540 and colleagues https://t.co/iVqHsgvAy8
2022-10-20 18:57:29 Vaccination alone did not induce neutralizing activity in the nasal mucosa, but that was achieved via breakthrough infections."These observations... .motivate the development and evaluation of a next generation of vaccines administered intranasally." https://t.co/XIaSiKDJ7R
2022-10-20 18:36:12 "We identified an ultrapotent pan-variant neutralizing antibody, that is a strong candidate for clinical development."https://t.co/jlo7fjwCr5@ScienceMagazine @veeslerlab https://t.co/bwBA8q2zfQ
2022-10-20 18:30:15 A feature @ScienceMagazine on what to do about lab virus work https://t.co/aZhzc3k7X8 by @jocelynkaiser https://t.co/Ypyp24G90K
2022-10-20 17:17:31 Also to note that 60%+ max is not the 80%+ protection vs hospitalization that was consistently seen prior to BA.5, (90%+ for Delta and prior strains) and that finding replicates 2 other studies.Underscores the importance and need for a variant-proof, pan-sarbecovirus vaccine
2022-10-20 17:07:07 Why a booster is important to maintain protection from hospitalization: waning immunityNew @CDCMMWR shows the protection vs BA.5 drops down to 37% (2 shots) and 29% (3 shots) after 4 monthshttps://t.co/DRB7tiyffUData are for all ages 18+ https://t.co/Pa0PtdlWIY
2022-10-20 15:30:35 In a prospective cohort of critically ill adults, sequencing the blood (metagenomics) identified the pathogen 99% and predicted sepsis in 74%https://t.co/tQTgyQHSjY@NatureMicrobiol @UCSF @klkalantar and colleagues https://t.co/wx4u4HpqD5
2022-10-20 13:33:04 "Middle-aged people accounted for the biggest losses in life expectancy"https://t.co/czRQeP2WkHMore at "In America and eastern Europe, covid-19 got worse in 2021" https://t.co/SxZup76Cic
2022-10-20 12:47:01 RT @bmj_latest: “This virus is so amenable to taking it down . . . But we’re just not acting like we can do this. And we can.” @EricTopol…
2022-10-20 01:56:23 RT @EricTopol: There's a lot of total BS out there about myocarditis in kids and adolescents. To state facts:1. CDC does NOT decide about…
2022-10-19 22:20:40 For children 5-11 years in males, 2nd dosethe rate is 2.5 per million https://t.co/kXEH3wMsZl
2022-10-19 22:14:25 There's a lot of total BS out there about myocarditis in kids and adolescents. To state facts:1. CDC does NOT decide about Covid vaccines in schools 2. There are no kids dying of myocarditis from the vaccines3. It is very rare, mild 4. The anti-vaxx world has gone beserk
2022-10-19 21:56:45 The BA.4.6 variant accounts for ~12% of US Covid cases (pattern of growth below, left). Its level of immune escape was characterized @NEJM today: 2-3 fold less neutralizing antibodies than BA.5 (below, right)https://t.co/WdRlUvagsW @BarouchLab https://t.co/HCJYiczVfX
2022-10-19 21:38:19 A timely, outstanding @NEJM review on myocarditis today https://t.co/WAT7pvAMZX by @Cristinabasso64 https://t.co/kx9NytqNro
2022-10-19 21:06:24 Randomized, placebo-controlled trial of the 2-dose @moderna_tx vaccine in children 6 months to 5 years, during Omicron. Safe in ~4,800 kids
2022-10-19 21:00:25 New @NEJM"Our study indicates that [Pfizer] vaccine-induced myocarditis in adolescents appears to be a rare adverse event [<
2022-10-19 19:10:16 "Alexa, what's a mechanical neural network?"https://t.co/3d8yQNsBO1 @SciRobotics #AI https://t.co/X5TbigpMCa
2022-10-19 18:00:25 4. No increased risk of miscarriage or other pregnancy complications from vaccination or booster https://t.co/mVFxD3aE8e
2022-10-19 18:00:23 3. Newborn/infant (0-5 months) avoidance of hospitalization by mother's vaccination https://t.co/T2Wut9L6kK
2022-10-19 18:00:21 2. Vaccination protected vs hospitalization vs Delta and Omicron infections with booster (same with ED or urgent care visits)But 57% of expectant mothers have not been vaccinated or had a booster https://t.co/e9BEJwfVse
2022-10-29 19:05:35 The #1 sleuth of life science data manipulation and imaging fraud, @MicrobiomDigest, has analyzed more than 100,000 papers since 2014. She reviews what she's learned and lays out what needs to change https://t.co/AYjYeVcrTP@nytopinion https://t.co/gw75OwQZb7
2022-10-29 17:49:56 @DrSidMukherjee Thinking back. Funny that I reviewed The Gene in Cellhttps://t.co/PYMcpbr1zj https://t.co/fYcV8huFOV
2022-10-29 17:27:33 Q—Before the pandemic, when was the last time an intervention's efficacy and safety was validated in >
2022-10-29 16:27:22 Song of the Cell, @DrSidMukherjee's new book, is an extraordinary work that covers the cell's history and future, along with its mysteries, like he did for genes in The Gene. Reviewed by @DShaywitz @WSJhttps://t.co/ec8WVRk0T6 https://t.co/YUSxRINVEb
2022-10-29 15:25:57 A ranking of the immune evasion for the new variantshttps://t.co/1lrjUMGa9X
2022-10-29 15:21:45 Good summary of the variant swarm/soup status @nature by @ewencallaway with @CorneliusRoemer @yunlong_cao https://t.co/wNwFgdLkvC https://t.co/jvAaShLJqh
2022-10-29 15:15:15 An encouraging sign for one of the (if not the) most immune evasive new variantsXBB is dominant in India and Bangladesh without a rise in cases or deaths to datehttps://t.co/kraBgpFU4V and @OurWorldInData https://t.co/oZdLOXtoSI
2022-10-28 19:37:55 Long-lived plasma cells: real time, cell-by-cell time stamping of their immune response after vaccinationhttps://t.co/bKWGL3a5rp half-life of ~700 days in the mouse model @SciImmunology @MonashUni https://t.co/vRFXcnB8Jy
2022-10-28 18:50:00 Billion-dollar experiments to "escape scientific stagnation"https://t.co/t9uGywZXnS https://t.co/fhmXKtENt6
2022-10-28 17:21:41 @uche_blackstock I'm not going anywhere, Uché. That's how I first met you
2022-10-28 17:18:01 @Nate_DiCamillo @CellCellPress unlocking the article https://t.co/8OakGeNT0I
2022-10-28 17:08:59 The case for some vigorous physical activity: association with reduced mortality, heart disease and cancer in ~72,000 people, mean age 63, followed ~6 yearshttps://t.co/h6XY9Cqms4@ESC_Journals @uk_biobank @Matthew_Ahmadi_ @M_Stamatakis https://t.co/pzYJf68EsU
2022-10-28 16:54:42 "Compelling evidence for the role of carboxylic acid in guiding the mosquito's preference toward specific people"https://t.co/wredsoM8ux @CellCellPress https://t.co/EvMS4VES25
2022-10-28 16:32:26 via @chrischirp In England, the share of cases (and spurt) of BQ.1.1 and BQ.1 is similar to the USHospital admissions are currently on the way down (for now at least) https://t.co/FmfnifCxAT
2022-10-28 15:17:45 @ACPinternists @scrippsresearch Thanks @ACPinternists!
2022-10-28 15:15:25 Besides the hopeful sign from France noted yesterday https://t.co/I4ujEQvJgw Region 2 of the US has the highest BQ.1.1/1, particularly New York, where new hospital admits have not shown a recent rise https://t.co/rcWUlpd8dk
2022-10-28 14:55:38 New US Covid genomics: BQ.1.1 and BQ.1 variants now account for 27% of cases, up from 17% a week ago, on a path to be dominant (>
2022-10-27 22:28:59 On a related front, metabolites from a specific gut microbiome bacterium in people with inflammatory bowel disease can promote tumor developmenthttps://t.co/6NNwlJvWmMhttps://t.co/hPXcuOt3ID https://t.co/72VEts7Soa
2022-10-27 22:15:34 Operation Nasal Vaccine. Please.https://t.co/OujfFxMgU6 @SciImmunology https://t.co/CtoZneSx9O
2022-10-27 21:49:26 Thanks to the swientists!https://t.co/YhPoxt6gaO @ScienceMagazine by @sciencecohen https://t.co/N48xJOHv12
2022-10-27 21:47:32 and this https://t.co/RnhEX54VOD
2022-10-27 19:11:59 @CathyLozupone @KristiKuhn @cu_medicine Agree!
2022-10-27 19:06:02 @BenIsraelow Delighted to do so, especially when it's so impressive and gives us much hope for a far better approach/defense
2022-10-27 18:30:09 Protective efficacy of the spike booster lasted for ~4 months, pan-sarbecovirus, using no adjuvants or replication-deficient or live attenuated virus (like FluMist), elicited broad neutralizing Abs.This is the variant-proof booster we need now to help prevent infections &
2022-10-27 18:16:56 Just published @ScienceMagazine A nasal vaccine booster (after primary vaccination) induces mucosal immunity —IgA, memory B and T cell—against the sarbecovirus family in the experimental modelhttps://t.co/j03xNjIXzhby @VirusesImmunity @tianyangmao and team @YaleIBIO @YaleMed https://t.co/M6LQUZWnlc
2022-10-27 17:44:25 RT @MassMedical: .@EricTopol said it would be a mistake to skip these shots. They still work, they just may not be much of an improvement o…
2022-10-27 17:39:01 Very hopeful signFrance is the 1st country in Europe to see the BQ.1.1 variant dominance (>
2022-10-26 21:05:00 The benefit of vaccination and boosters, along with prior Covid, against Omicron infections, in the California prison systemhttps://t.co/VSwHQIkwrD @NEJM https://t.co/3xg2Yn8DBm
2022-10-26 18:42:07 @Alexander_Tin @CNN @US_FDA @moderna_tx The number of participants in each of the 2 bivalent BA.5 booster independent studies is far greater than the ones Pfizer and Moderna have thus presented (zero) and are quite typical for assessment of neutralizing antibody response throughput the pandemic
2022-10-24 01:51:07 That Singapore's XBB variant wave was not severe, with relaxed mitigation, as @Fiona_M_Russell points out, is v encouraging https://t.co/tJuJ82OOBO —XBB's immune evasion could've ->
2022-10-24 01:21:15 @BagaiDr Many thanks Dr, Bagai!
2022-10-23 20:54:45 A booster is your best shot now. Why?https://t.co/G9Gnosk8E8
2022-10-23 18:04:32 It's not a good sign when 3 shots and a breakthrough (BA.1) infection (lower panel) doesn't elicit neutralizing antibodies to some of the new variants (BQ.1.1, XBB, BA.2.75.2) https://t.co/YS9rbTlSGZ
2022-10-23 16:21:46 RT @paula_span: The new bivalent COVID booster: Older folks, a highly vaccinated group, appear less interested in getting it than earlier s…
2022-10-23 16:17:42 @elderconsult I think the likely explanation is a high rate of prior infection, particularly with the Beta variant which seems to provide more cross-immunity than the others
2022-10-22 22:09:29 Thanks for the critique and feedback, @AstroKatie, @choo_ek and many others. A sense of equivalency was never intended. Preventing deaths, hospitalizations and #LongCovid towers over any liabilities.Here's a fixed version https://t.co/hrlYbI8rEI
2022-10-22 20:10:45 For the first year of vaccines, over 20 million lives saved around the world through December 2021 https://t.co/4GnPgEvg7W
2022-10-22 20:10:44 End of July 202291% reduction of deaths, all ages https://t.co/GIPkSo2daH
2022-10-22 20:10:42 Vaccines and boosters save lives. Across all ages.96% reduction of deaths for 2 boosters vs unvaccinatedEnd of May 2022@OurWorldInData https://t.co/UYkn5iszKT
2022-10-22 19:52:45 RT @cshperspectives: Sci comm irony when the first scientist quoted in a story has deleted their twitter account by the time the article ap…
2022-10-22 19:51:15 @JusDayDa @_TheAncientOne_ @MoritzGerstung Yes, that one is good, too. I had summarized it yesterdayhttps://t.co/fS78A4Vrwr
2022-10-22 19:32:01 @JusDayDa @MoritzGerstung Best I've seen is from @yunlong_cao and colleagueshttps://t.co/qWJ4AGtiur
2022-10-22 19:29:06 Avoiding #LongCovidhttps://t.co/VIVNew8bGWMy interview with @maggiemfox @Medscape, video w/ transcript https://t.co/FOpoBMAEOe
2022-10-22 16:59:36 A review of how #AI has been used during the pandemichttps://t.co/tvjS0ifKFE @PLOSDigiHealth "No clinical trials evaluating any applications impact on patient health" by @RANDCorporation @carlberdahl https://t.co/GeoWpysyyj
2022-10-22 15:31:45 The BQ.1.x wave projection for the US, and calculations for many other countries based on growth advantage vs BA.5, by @MoritzGerstung https://t.co/4TozbJWNLa https://t.co/wtuI1qLi4r
2022-10-22 14:15:56 Their XBB wave was projected to exceed BA.5.Strong NPI mitigation practices and very high vaccine/booster uptake (a top 10 country) likely contributed https://t.co/93Vd3T3Qg2
2022-10-22 14:05:17 This is very good news.The XBB variant wave in Singapore is in descenthttps://t.co/mZS5FePzrNXBB and BQ.1.1 are 2 of the most immune evasive variants and Singapore was the first country to experience a wave induced by one of them, now letting up https://t.co/DbkSC4OPN7
2022-10-22 01:27:48 @BMcranty @AstroKatie @Sarcasmorator I don't consider major reduction of deaths, hospitalizations, and #LongCovid as "meh"
2022-10-21 22:51:43 91% reduction of Covid deaths for age 50+ with 2 boosters, August 2022, vs unvaccinated BA.5 wave https://t.co/HGyjNwCm0v https://t.co/VI7LzxaLtM
2022-10-21 22:11:19 @AstroKatie I'm with you. Trying to provide as much balance as possible
2022-10-21 22:08:33 Yesterday's @CDCMMWR report that shows slippage of protection vs hospitalization after 4 months, age 18+, during BA.5 wavehttps://t.co/DRB7tiyffU https://t.co/1bTzbZvhAv
2022-10-21 22:05:10 @Sara43347888 The answer is NO. The @sfchronicle headline is terrible and worse than that is to have it behind a paywall. Unacceptable.
2022-10-21 22:01:41 For ages 18-49, the 72% reduction of Covid hospitalizations with ≥ boosterhttps://t.co/M2Bu9rj1Ve https://t.co/DX8wcxAzzt
2022-10-21 21:48:59 Since Omicron in late 2021, mRNA booster protection vs infections &
2022-10-21 20:53:57 @JohnRossMD That's one of several refutes See @K_G_Andersen https://t.co/HcVEo29XaAAnd @Friedemann1https://t.co/VJCmgWR1Vj
2022-10-21 20:45:55 RT @JohnRossMD: In case you missed it, UK COVID minimizer Francois Balloux has deleted his account after amplifying a spectacularly wrong p…
2022-10-21 18:27:42 RT @JReinerMD: Pfizer projects that it will make $32 billion from its COVID vaccine in 2022 and $22 billion from Paxlovid. Their plan to ch…
2022-10-21 17:41:28 The BQ variants and the UShttps://t.co/KEeCny0P9A by @ErinMPrater @FortuneMagazine
2022-10-21 16:36:27 RT @K_G_Andersen: BQ.1(.1)* picking up steam, but still too low to be making a major difference in cases/hospitalizations - follow this tre…
2022-10-21 15:59:15 That's right—Covid boosters aren't for everyone.But for WSJ to print this seriously flawed claim about cardiac deaths in men age 18-39 is inappropriate, to say the least https://t.co/KCox0mhlHG https://t.co/NixQ2Uki1R
2022-10-21 15:02:26 New lab assessment of these variantsBQ.1.1 has the most immune evasion and fusogenicityhttps://t.co/5FQn5FxOZ1 https://t.co/PmZPkQHB4n
2022-10-21 14:50:01 What are the #SARSCoV2 variants accounting for US cases?New CDC genomic surveillance updateOn the rise: Predominantly BQ.1 and BQ.1.1 (~17%), also BF.7 (7%), BA.2.75.2On the decline: BA.5, BA.4.6https://t.co/jjl2AnwOWX https://t.co/r7i6cYnjSe
2022-10-21 14:37:20 RT @mhornig: Not convinced efforts to avoid #SARSCoV2 infx are worth it? Think #LongCOVID and potential for #MECFS are fantasy? Please list…
2022-10-21 14:20:48 Myalgic encephalomyelitis was first recorded in 1934 in Los Angeles after an outbreak of atypical polio. It has taken nearly a century and #LongCovid to "get needed attention"https://t.co/ryyI15mfnf @NanetteAsimov #mecfs https://t.co/xOYiOk9R2A
2022-10-21 02:54:11 Keep an eye on New York, leading the country with % cases BQ.1.1, bellwether for the next wave https://t.co/vw77IAyHJj (update, first picked up by @JPWeiland) https://t.co/MPJSVvzqEY
2022-10-21 01:50:07 The inversion (next wave) is likely starting by the rise in hospitalizations. Great time for CDC to stop daily tracking https://t.co/RXymG9t41x
2022-10-20 23:56:25 On the imprinting issue, in the Discussion"antibody responses to some Omicron S[spike]-specific epitopes were hindered by prior antigenic exposure" https://t.co/w9oiWH8s5A
2022-10-20 22:39:04 Is the science information credible? For the competent outsider:https://t.co/cuyEKL762s@danrpimentel @ScienceMagazine https://t.co/z8WsB1TOjF
2022-10-20 20:02:03 The mechanism by which time-restricted eating limits obesity (in mice)https://t.co/gENt2Muxtq@DamienLagarde @kazaklab @ScienceMagazine @ScienceVisualsre:https://t.co/DN3oCsON5y@JoeBass91471540 and colleagues https://t.co/iVqHsgvAy8
2022-10-20 18:57:29 Vaccination alone did not induce neutralizing activity in the nasal mucosa, but that was achieved via breakthrough infections."These observations... .motivate the development and evaluation of a next generation of vaccines administered intranasally." https://t.co/XIaSiKDJ7R
2022-10-20 18:36:12 "We identified an ultrapotent pan-variant neutralizing antibody, that is a strong candidate for clinical development."https://t.co/jlo7fjwCr5@ScienceMagazine @veeslerlab https://t.co/bwBA8q2zfQ
2022-10-20 18:30:15 A feature @ScienceMagazine on what to do about lab virus work https://t.co/aZhzc3k7X8 by @jocelynkaiser https://t.co/Ypyp24G90K
2022-10-20 17:17:31 Also to note that 60%+ max is not the 80%+ protection vs hospitalization that was consistently seen prior to BA.5, (90%+ for Delta and prior strains) and that finding replicates 2 other studies.Underscores the importance and need for a variant-proof, pan-sarbecovirus vaccine
2022-10-20 17:07:07 Why a booster is important to maintain protection from hospitalization: waning immunityNew @CDCMMWR shows the protection vs BA.5 drops down to 37% (2 shots) and 29% (3 shots) after 4 monthshttps://t.co/DRB7tiyffUData are for all ages 18+ https://t.co/Pa0PtdlWIY
2022-10-20 15:30:35 In a prospective cohort of critically ill adults, sequencing the blood (metagenomics) identified the pathogen 99% and predicted sepsis in 74%https://t.co/tQTgyQHSjY@NatureMicrobiol @UCSF @klkalantar and colleagues https://t.co/wx4u4HpqD5
2022-10-20 13:33:04 "Middle-aged people accounted for the biggest losses in life expectancy"https://t.co/czRQeP2WkHMore at "In America and eastern Europe, covid-19 got worse in 2021" https://t.co/SxZup76Cic
2022-10-20 12:47:01 RT @bmj_latest: “This virus is so amenable to taking it down . . . But we’re just not acting like we can do this. And we can.” @EricTopol…
2022-10-20 01:56:23 RT @EricTopol: There's a lot of total BS out there about myocarditis in kids and adolescents. To state facts:1. CDC does NOT decide about…
2022-10-19 22:20:40 For children 5-11 years in males, 2nd dosethe rate is 2.5 per million https://t.co/kXEH3wMsZl
2022-10-19 22:14:25 There's a lot of total BS out there about myocarditis in kids and adolescents. To state facts:1. CDC does NOT decide about Covid vaccines in schools 2. There are no kids dying of myocarditis from the vaccines3. It is very rare, mild 4. The anti-vaxx world has gone beserk
2022-10-19 21:56:45 The BA.4.6 variant accounts for ~12% of US Covid cases (pattern of growth below, left). Its level of immune escape was characterized @NEJM today: 2-3 fold less neutralizing antibodies than BA.5 (below, right)https://t.co/WdRlUvagsW @BarouchLab https://t.co/HCJYiczVfX
2022-10-19 21:38:19 A timely, outstanding @NEJM review on myocarditis today https://t.co/WAT7pvAMZX by @Cristinabasso64 https://t.co/kx9NytqNro
2022-10-19 21:06:24 Randomized, placebo-controlled trial of the 2-dose @moderna_tx vaccine in children 6 months to 5 years, during Omicron. Safe in ~4,800 kids
2022-10-19 21:00:25 New @NEJM"Our study indicates that [Pfizer] vaccine-induced myocarditis in adolescents appears to be a rare adverse event [<
2022-10-19 19:10:16 "Alexa, what's a mechanical neural network?"https://t.co/3d8yQNsBO1 @SciRobotics #AI https://t.co/X5TbigpMCa
2022-10-19 18:00:25 4. No increased risk of miscarriage or other pregnancy complications from vaccination or booster https://t.co/mVFxD3aE8e
2022-10-19 18:00:23 3. Newborn/infant (0-5 months) avoidance of hospitalization by mother's vaccination https://t.co/T2Wut9L6kK
2022-10-19 18:00:21 2. Vaccination protected vs hospitalization vs Delta and Omicron infections with booster (same with ED or urgent care visits)But 57% of expectant mothers have not been vaccinated or had a booster https://t.co/e9BEJwfVse
2022-11-18 00:42:08 By current variant growth advantage patterns, the next couple of months in the US will be BQ.1.x dominated. Bivalent boosters will help protect
2022-11-18 00:20:49 @WHCOS Nicely put, Ron. Thanks!
2022-11-18 00:20:19 RT @WHCOS: In simpler terms: Go get your new COVID vaccination now.
2022-11-18 00:06:48 What science forgot during the pandemic https://t.co/12ffbs3ZOF by @richardhorton1 @TheLancet https://t.co/aoJSA3dEco
2022-11-17 23:56:45 A new report confirms the immune escape of the BQ.1.1 variant, along with BA.4.6 &
2022-11-17 23:26:54 We still don't have a way to diagnosis chronic traumatic encephalopathy (CTE) in people who are alive, but may be getting closer https://t.co/SftRQR7TWD by @el_belson @NYTSports https://t.co/BTh6oXUxRg
2022-11-17 21:47:06 RT @rowlsmanthorpe: Long covid has wrecked my life It’s bad, very bad. But you knew that already I want to tell you a hopeful story. A st…
2022-11-17 19:37:27 @PraliNoisette I don't see any sign of that https://t.co/e7u7aZCfBZ
2022-11-17 19:12:51 To note https://t.co/y2qdjFrvDR
2022-11-17 19:11:30 75 years later we have chips with >
2022-11-17 18:08:47 BA.5, déjà vu https://t.co/eILO8PxIkY
2022-11-17 17:33:41 RT @linseymarr: You get a 2-for-1 with filtration. It removes virus from the air and PM2.5 that is associated with an increased risk of inf…
2022-11-17 17:28:45 RT @Aiims1742: Important #OpenAccess paper in @Cancer_Cell from @CharlesSwanton &
2022-11-17 17:09:54 Strong evidence that particulate matter air pollution (ambient PM2.5) increases the risk of Covid infection, a systematic analysis https://t.co/RueG44Hk2m @MonashUni https://t.co/kpREoqJVPi
2022-11-17 15:46:50 About 1 in 5 of us have an APOE4 gene variant, the #1 genetic risk factor for Alzheimer's disease. But the mechanism for brain injury was a mystery, now getting unraveled (cholesterol processing by oligodendrocytes) https://t.co/gIpGt0CA28 @nature https://t.co/hbmdpO6R3t https://t.co/4zFZIhUTCI
2022-11-17 01:27:50 @amitsurg Because they do. That's mostly related to the excess of rebound after Paxlovid
2022-11-17 00:58:05 We've (re-)learned a few important lessons from the Paxlovid rebound experience about randomized trials and real world evidence Reviewed here https://t.co/jmT9vIipg9
2022-11-16 19:46:41 The Paxlovid rebound story New data reviewed in the 16 November daily briefing of Ground Truths https://t.co/jmT9vIipg9
2022-11-16 17:48:15 The US Covid death rate (7-day average) drops below 300 for the first time since June 2022. Lowest since pandemic began was 222 in July 2021. https://t.co/Cze8bZgtVr https://t.co/uxGosRY1KO
2022-11-16 17:14:12 Immunotherapy can induce myocarditis but the mechanism has been poorly understood. A new report @nature today supports the culprit auto-antigen role of α-myosin and cytotoxic T-cells directed to it https://t.co/uPRUQBbkVh by @MargaretAxelrod @BalkoLab https://t.co/vWZP1IcW19
2022-11-16 16:37:07 Humidity (indoor, relative) is associated with outcomes of Covid infections, a population-based study in 121 countries https://t.co/dWMmyMfBSL https://t.co/hW7Jq1mhdo
2022-11-16 01:17:21 RT @PeterHotez: Important and well-conducted study by @EricTopol My take: even though rebound is real and significant, in my conversation…
2022-11-15 23:33:25 For the people pointing out that @POTUS, @CDCDirector and Tony Fauci all had Paxlovid rebound, that's why you do prospective, systematic studies. We've learned that "rebound" also occurs without Paxlovid and that anecdotes/twitter are not representative of the real world
2022-11-15 20:14:34 Each participant did rapid antigen testing every other day through day 15, symptom surveys through day 17, and are being followed for 6 months https://t.co/8bDtswdytR
2022-11-15 20:00:32 The event curves for Paxlovid treated compared with controls https://t.co/2ykeOuBUAX
2022-11-15 19:56:25 Our prospective Paxlovid rebound study with controls preprint is posted By symptoms: ~12% rebound (19% Pax vs 7% controls) By positive testing: ~5% rebound (14% Pax vs 9% controls) Much lower than many estimates https://t.co/czeGEYIJvA by @JayPandit @michaelmina_lab @ScrippsRTI
2022-11-15 19:45:43 Foundation #AI models come to science https://t.co/G7Xx31w1Of https://t.co/HNjVOs3J4I
2022-11-15 19:23:17 @Jdrodric12 that's right!
2022-11-15 18:47:56 @SarahWLaurence @ScrippsRTI Thank you!
2022-11-15 18:31:49 On a day when the world has reached about ~8 billion people, it's notable there have been >
2022-11-15 17:10:19 @surrogateexpare @Medscape Included here https://t.co/bugfFk44sh@Medscape Please fix the links
2022-11-15 17:09:38 This post has all the relevant links and review the recent its for protection vs #LongCovid https://t.co/bugfFk44sh
2022-11-15 16:30:20 Paxlovid interactionsA new report claims 14.6% of patients had contraindications to treatment. But most of these meds could have been safely stopped for 5 dayshttps://t.co/FP3o0J0eBzMore on this herehttps://t.co/i3pUyAJlAs @Medscape https://t.co/0tsAf3xUqu
2022-11-15 16:11:35 Start of new waves in South Korea and Japan, having sustained recent BA.5 waves and this variant still accounts for most new casesThe pandemic isn't over https://t.co/DhwWhZ4CJi
2022-11-15 16:01:28 Here's the article. A potential path to preventing brain tissue from dying https://t.co/ODGuD8X8iy
2022-11-15 00:48:03 Today's pandemic briefing on new booster data and the thick soup of new variantshttps://t.co/LA3nl6FxSx
2022-11-14 17:22:13 RT @danrdanny: Excited to see our work on 3-hour genome sequencing highlighted here! If you think this is interesting we have a bench scien…
2022-11-14 17:04:44 The potential for detecting heart dysfunction (ejection fraction <
2022-11-14 14:37:14 RT @EricTopol: Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so m…
2022-11-14 14:28:16 In aggregate, solid evidence that the bivalent booster elicits a strong and broadened neutralizing antibody immune response. Yet, less than 27% of Americans 65+, the have had it and poor uptake across all age groupshttps://t.co/V5Xlj3cKln
2022-11-14 14:28:15 https://t.co/fJbLUdcYJdCoverage @statnews by @matthewherper w/ @SutharLab, whose results were replicated by the new data (Table)
2022-11-14 12:00:01 Moderna BA.5 bivalent booster results announced (via @moderna_tx press release)—largest study to date of >
2022-11-18 00:42:08 By current variant growth advantage patterns, the next couple of months in the US will be BQ.1.x dominated. Bivalent boosters will help protect
2022-11-18 00:20:49 @WHCOS Nicely put, Ron. Thanks!
2022-11-18 00:20:19 RT @WHCOS: In simpler terms: Go get your new COVID vaccination now.
2022-11-18 00:06:48 What science forgot during the pandemic https://t.co/12ffbs3ZOF by @richardhorton1 @TheLancet https://t.co/aoJSA3dEco
2022-11-17 23:56:45 A new report confirms the immune escape of the BQ.1.1 variant, along with BA.4.6 &
2022-11-17 23:26:54 We still don't have a way to diagnosis chronic traumatic encephalopathy (CTE) in people who are alive, but may be getting closer https://t.co/SftRQR7TWD by @el_belson @NYTSports https://t.co/BTh6oXUxRg
2022-11-17 21:47:06 RT @rowlsmanthorpe: Long covid has wrecked my life It’s bad, very bad. But you knew that already I want to tell you a hopeful story. A st…
2022-11-17 19:37:27 @PraliNoisette I don't see any sign of that https://t.co/e7u7aZCfBZ
2022-11-17 19:12:51 To note https://t.co/y2qdjFrvDR
2022-11-17 19:11:30 75 years later we have chips with >
2022-11-17 18:08:47 BA.5, déjà vu https://t.co/eILO8PxIkY
2022-11-17 17:33:41 RT @linseymarr: You get a 2-for-1 with filtration. It removes virus from the air and PM2.5 that is associated with an increased risk of inf…
2022-11-17 17:28:45 RT @Aiims1742: Important #OpenAccess paper in @Cancer_Cell from @CharlesSwanton &
2022-11-17 17:09:54 Strong evidence that particulate matter air pollution (ambient PM2.5) increases the risk of Covid infection, a systematic analysis https://t.co/RueG44Hk2m @MonashUni https://t.co/kpREoqJVPi
2022-11-17 15:46:50 About 1 in 5 of us have an APOE4 gene variant, the #1 genetic risk factor for Alzheimer's disease. But the mechanism for brain injury was a mystery, now getting unraveled (cholesterol processing by oligodendrocytes) https://t.co/gIpGt0CA28 @nature https://t.co/hbmdpO6R3t https://t.co/4zFZIhUTCI
2022-11-17 01:27:50 @amitsurg Because they do. That's mostly related to the excess of rebound after Paxlovid
2022-11-17 00:58:05 We've (re-)learned a few important lessons from the Paxlovid rebound experience about randomized trials and real world evidence Reviewed here https://t.co/jmT9vIipg9
2022-11-16 19:46:41 The Paxlovid rebound story New data reviewed in the 16 November daily briefing of Ground Truths https://t.co/jmT9vIipg9
2022-11-16 17:48:15 The US Covid death rate (7-day average) drops below 300 for the first time since June 2022. Lowest since pandemic began was 222 in July 2021. https://t.co/Cze8bZgtVr https://t.co/uxGosRY1KO
2022-11-16 17:14:12 Immunotherapy can induce myocarditis but the mechanism has been poorly understood. A new report @nature today supports the culprit auto-antigen role of α-myosin and cytotoxic T-cells directed to it https://t.co/uPRUQBbkVh by @MargaretAxelrod @BalkoLab https://t.co/vWZP1IcW19
2022-11-16 16:37:07 Humidity (indoor, relative) is associated with outcomes of Covid infections, a population-based study in 121 countries https://t.co/dWMmyMfBSL https://t.co/hW7Jq1mhdo
2022-11-16 01:17:21 RT @PeterHotez: Important and well-conducted study by @EricTopol My take: even though rebound is real and significant, in my conversation…
2022-11-15 23:33:25 For the people pointing out that @POTUS, @CDCDirector and Tony Fauci all had Paxlovid rebound, that's why you do prospective, systematic studies. We've learned that "rebound" also occurs without Paxlovid and that anecdotes/twitter are not representative of the real world
2022-11-15 20:14:34 Each participant did rapid antigen testing every other day through day 15, symptom surveys through day 17, and are being followed for 6 months https://t.co/8bDtswdytR
2022-11-15 20:00:32 The event curves for Paxlovid treated compared with controls https://t.co/2ykeOuBUAX
2022-11-15 19:56:25 Our prospective Paxlovid rebound study with controls preprint is posted By symptoms: ~12% rebound (19% Pax vs 7% controls) By positive testing: ~5% rebound (14% Pax vs 9% controls) Much lower than many estimates https://t.co/czeGEYIJvA by @JayPandit @michaelmina_lab @ScrippsRTI
2022-11-15 19:45:43 Foundation #AI models come to science https://t.co/G7Xx31w1Of https://t.co/HNjVOs3J4I
2022-11-15 19:23:17 @Jdrodric12 that's right!
2022-11-15 18:47:56 @SarahWLaurence @ScrippsRTI Thank you!
2022-11-15 18:31:49 On a day when the world has reached about ~8 billion people, it's notable there have been >
2022-11-15 17:10:19 @surrogateexpare @Medscape Included here https://t.co/bugfFk44sh@Medscape Please fix the links
2022-11-15 17:09:38 This post has all the relevant links and review the recent its for protection vs #LongCovid https://t.co/bugfFk44sh
2022-11-15 16:30:20 Paxlovid interactionsA new report claims 14.6% of patients had contraindications to treatment. But most of these meds could have been safely stopped for 5 dayshttps://t.co/FP3o0J0eBzMore on this herehttps://t.co/i3pUyAJlAs @Medscape https://t.co/0tsAf3xUqu
2022-11-15 16:11:35 Start of new waves in South Korea and Japan, having sustained recent BA.5 waves and this variant still accounts for most new casesThe pandemic isn't over https://t.co/DhwWhZ4CJi
2022-11-15 16:01:28 Here's the article. A potential path to preventing brain tissue from dying https://t.co/ODGuD8X8iy
2022-11-15 00:48:03 Today's pandemic briefing on new booster data and the thick soup of new variantshttps://t.co/LA3nl6FxSx
2022-11-14 17:22:13 RT @danrdanny: Excited to see our work on 3-hour genome sequencing highlighted here! If you think this is interesting we have a bench scien…
2022-11-14 17:04:44 The potential for detecting heart dysfunction (ejection fraction <
2022-11-14 14:37:14 RT @EricTopol: Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so m…
2022-11-14 14:28:16 In aggregate, solid evidence that the bivalent booster elicits a strong and broadened neutralizing antibody immune response. Yet, less than 27% of Americans 65+, the have had it and poor uptake across all age groupshttps://t.co/V5Xlj3cKln
2022-11-14 14:28:15 https://t.co/fJbLUdcYJdCoverage @statnews by @matthewherper w/ @SutharLab, whose results were replicated by the new data (Table)
2022-11-14 12:00:01 Moderna BA.5 bivalent booster results announced (via @moderna_tx press release)—largest study to date of >
2022-11-19 00:57:34 This poses a major concern for immunocompromised who have benefited from Evusheld (preventive) &
2022-11-19 00:57:33 The BQ.1.1 variant, as compared with many of the other new variants, is resistant to all clinically used monoclonal antibodies. BQ.1/BQ.1.1 are now the dominant variants in the United States https://t.co/PCFPSGF2uy @TheLancetInfDis https://t.co/dHucxoGokC
2022-11-18 21:17:45 Good news: 1st drug to alter the course of Type 1 diabetes in 100 years approved by @US_FDA Bad news: it costs ~$200,000/14-day treatment
2022-11-18 20:40:04 @legalnomads BA.1 bivalent induces about half as much neutralizing antibodies vs BA.5 as the BA.5 bivalent (live virus assays), both better than original booster. Whether that translates to any difference clinically is unclear.
2022-11-18 20:12:01 The bivalent BA.1 booster is being use in many countries around the world, but data are limited compared with the original (WT) booster against BA.5. New today: doubling of neutralizing antibodies https://t.co/M2YUB5wpH4 (BA.5 bivalent was ~3-5X WT in several recent studies) https://t.co/xYwnfcXkm6
2022-11-18 18:44:04 How to improve science discovery and productivity? Not just about money (see graph below): funding fast, bets on talent/people, take risk, think big https://t.co/HEAXu2L87H by @greg_ip w/ @patrickc @tylercowen @pdhsu https://t.co/7O6qplOf9C
2022-11-18 18:01:46 @KMunoz46 Correct. That's why there's no good explanation
2022-11-18 17:44:15 RT @ElinSilveous: “Foreign rivals have raced ahead in approving long-awaited nasal-spray vaccines, including one invented in St. Louis, cre…
2022-11-18 17:27:39 Does going to @NFL games increase risk of Covid? https://t.co/UzghLiDCgT Interesting findings of an association in the 14-21 day postgame period when >
2022-11-18 16:57:29 If you'd like to boost your protection vs BQ.1.1, 2 new studies that back up the bivalent as the way to get that done https://t.co/wAoTyur6be https://t.co/fDF4KEyJAL https://t.co/FiBnQRxlMG
2022-11-18 16:52:03 US Covid genomics
2022-11-18 15:54:32 A systematic review of Covid vaccines for kids age 5 to 11 (30 studies) Effectiveness 75% vs hospitalization
2022-11-18 15:45:27 @TopherSpiro46 @AshishKJha46 I know, Topher. Absolutely no reason for refusal of Congress and failure to fund. Appreciate @ashishkjha's strong advocacy
2022-11-18 14:58:07 An explainer for why the US is not pursuing nasal vaccines. TLDR: there is no good explanation https://t.co/Ih6ypzOva7 by @benjmueller w/ @VirusesImmunity @florian_krammer
2022-11-18 05:38:35 @hola_jonathan Many thanks!
2022-11-18 05:37:46 @amuendelheim Thanks!
2022-11-18 05:10:48 I'll be here until the lights go out........ You can also find me @erictopol@mstdn.social and https://t.co/YllXWa0b4k https://t.co/5rfMlDkCdM
2022-11-18 03:51:13 @lainemartin1 Very appreciative of your note!
2022-11-18 03:33:22 Refers to BQ.1.1 (see blue arrow)
2022-11-18 03:32:12 New data for why a bivalent booster will help: "These data suggest the bivalent BA.4/5 vaccine is more immunogenic than the original ...vaccine against circulating Omicron sublineages, including BQ.1.1 that is becoming prevalent globally." https://t.co/wAoTyur6be Get boosted! https://t.co/j21g0bELIp
2022-11-18 00:42:08 By current variant growth advantage patterns, the next couple of months in the US will be BQ.1.x dominated. Bivalent boosters will help protect
2022-11-18 00:20:49 @WHCOS Nicely put, Ron. Thanks!
2022-11-18 00:20:19 RT @WHCOS: In simpler terms: Go get your new COVID vaccination now.
2022-11-18 00:06:48 What science forgot during the pandemic https://t.co/12ffbs3ZOF by @richardhorton1 @TheLancet https://t.co/aoJSA3dEco
2022-11-17 23:56:45 A new report confirms the immune escape of the BQ.1.1 variant, along with BA.4.6 &
2022-11-17 23:26:54 We still don't have a way to diagnosis chronic traumatic encephalopathy (CTE) in people who are alive, but may be getting closer https://t.co/SftRQR7TWD by @el_belson @NYTSports https://t.co/BTh6oXUxRg
2022-11-17 21:47:06 RT @rowlsmanthorpe: Long covid has wrecked my life It’s bad, very bad. But you knew that already I want to tell you a hopeful story. A st…
2022-11-17 19:37:27 @PraliNoisette I don't see any sign of that https://t.co/e7u7aZCfBZ
2022-11-17 19:12:51 To note https://t.co/y2qdjFrvDR
2022-11-17 19:11:30 75 years later we have chips with >
2022-11-17 18:08:47 BA.5, déjà vu https://t.co/eILO8PxIkY
2022-11-17 17:33:41 RT @linseymarr: You get a 2-for-1 with filtration. It removes virus from the air and PM2.5 that is associated with an increased risk of inf…
2022-11-17 17:28:45 RT @Aiims1742: Important #OpenAccess paper in @Cancer_Cell from @CharlesSwanton &
2022-11-17 17:09:54 Strong evidence that particulate matter air pollution (ambient PM2.5) increases the risk of Covid infection, a systematic analysis https://t.co/RueG44Hk2m @MonashUni https://t.co/kpREoqJVPi
2022-11-17 15:46:50 About 1 in 5 of us have an APOE4 gene variant, the #1 genetic risk factor for Alzheimer's disease. But the mechanism for brain injury was a mystery, now getting unraveled (cholesterol processing by oligodendrocytes) https://t.co/gIpGt0CA28 @nature https://t.co/hbmdpO6R3t https://t.co/4zFZIhUTCI
2022-11-17 01:27:50 @amitsurg Because they do. That's mostly related to the excess of rebound after Paxlovid
2022-11-17 00:58:05 We've (re-)learned a few important lessons from the Paxlovid rebound experience about randomized trials and real world evidence Reviewed here https://t.co/jmT9vIipg9
2022-11-16 19:46:41 The Paxlovid rebound story New data reviewed in the 16 November daily briefing of Ground Truths https://t.co/jmT9vIipg9
2022-11-16 17:48:15 The US Covid death rate (7-day average) drops below 300 for the first time since June 2022. Lowest since pandemic began was 222 in July 2021. https://t.co/Cze8bZgtVr https://t.co/uxGosRY1KO
2022-11-16 17:14:12 Immunotherapy can induce myocarditis but the mechanism has been poorly understood. A new report @nature today supports the culprit auto-antigen role of α-myosin and cytotoxic T-cells directed to it https://t.co/uPRUQBbkVh by @MargaretAxelrod @BalkoLab https://t.co/vWZP1IcW19
2022-11-16 16:37:07 Humidity (indoor, relative) is associated with outcomes of Covid infections, a population-based study in 121 countries https://t.co/dWMmyMfBSL https://t.co/hW7Jq1mhdo
2022-11-16 01:17:21 RT @PeterHotez: Important and well-conducted study by @EricTopol My take: even though rebound is real and significant, in my conversation…
2022-11-15 23:33:25 For the people pointing out that @POTUS, @CDCDirector and Tony Fauci all had Paxlovid rebound, that's why you do prospective, systematic studies. We've learned that "rebound" also occurs without Paxlovid and that anecdotes/twitter are not representative of the real world
2022-11-15 20:14:34 Each participant did rapid antigen testing every other day through day 15, symptom surveys through day 17, and are being followed for 6 months https://t.co/8bDtswdytR
2022-11-15 20:00:32 The event curves for Paxlovid treated compared with controls https://t.co/2ykeOuBUAX
2022-11-15 19:56:25 Our prospective Paxlovid rebound study with controls preprint is posted By symptoms: ~12% rebound (19% Pax vs 7% controls) By positive testing: ~5% rebound (14% Pax vs 9% controls) Much lower than many estimates https://t.co/czeGEYIJvA by @JayPandit @michaelmina_lab @ScrippsRTI
2022-11-15 19:45:43 Foundation #AI models come to science https://t.co/G7Xx31w1Of https://t.co/HNjVOs3J4I
2022-11-15 19:23:17 @Jdrodric12 that's right!
2022-11-15 18:47:56 @SarahWLaurence @ScrippsRTI Thank you!
2022-11-15 18:31:49 On a day when the world has reached about ~8 billion people, it's notable there have been >
2022-11-15 17:10:19 @surrogateexpare @Medscape Included here https://t.co/bugfFk44sh@Medscape Please fix the links
2022-11-15 17:09:38 This post has all the relevant links and review the recent its for protection vs #LongCovid https://t.co/bugfFk44sh
2022-11-15 16:30:20 Paxlovid interactionsA new report claims 14.6% of patients had contraindications to treatment. But most of these meds could have been safely stopped for 5 dayshttps://t.co/FP3o0J0eBzMore on this herehttps://t.co/i3pUyAJlAs @Medscape https://t.co/0tsAf3xUqu
2022-11-15 16:11:35 Start of new waves in South Korea and Japan, having sustained recent BA.5 waves and this variant still accounts for most new casesThe pandemic isn't over https://t.co/DhwWhZ4CJi
2022-11-15 16:01:28 Here's the article. A potential path to preventing brain tissue from dying https://t.co/ODGuD8X8iy
2022-11-15 00:48:03 Today's pandemic briefing on new booster data and the thick soup of new variantshttps://t.co/LA3nl6FxSx
2022-11-14 17:22:13 RT @danrdanny: Excited to see our work on 3-hour genome sequencing highlighted here! If you think this is interesting we have a bench scien…
2022-11-14 17:04:44 The potential for detecting heart dysfunction (ejection fraction <
2022-11-14 14:37:14 RT @EricTopol: Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so m…
2022-11-14 14:28:16 In aggregate, solid evidence that the bivalent booster elicits a strong and broadened neutralizing antibody immune response. Yet, less than 27% of Americans 65+, the have had it and poor uptake across all age groupshttps://t.co/V5Xlj3cKln
2022-11-14 14:28:15 https://t.co/fJbLUdcYJdCoverage @statnews by @matthewherper w/ @SutharLab, whose results were replicated by the new data (Table)
2022-11-14 12:00:01 Moderna BA.5 bivalent booster results announced (via @moderna_tx press release)—largest study to date of >
2022-11-19 20:21:41 A new and useful perspective on this report @NatRevNeurol https://t.co/wZ9kvh567Q by @alessandro5161 and @andreapilotto https://t.co/cjturtGVq2
2022-11-19 20:00:42 @TheLarvinMewis Thank you!
2022-11-19 19:46:26 My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SARSCoV2 variant with a marked increase in immune evasion not to have induced a wave. https://t.co/DqMJ7LAALu
2022-11-19 15:35:10 Correcting my typo: it's ronna, not rona More on this here @nature by @LizzieGibney https://t.co/Erb4zTYWCl https://t.co/zMGRoGHeTk
2022-11-19 15:20:02 I thought that many bytes should be named helluva but the new name is quetta https://t.co/d77lA6LTc2
2022-11-19 00:57:34 This poses a major concern for immunocompromised who have benefited from Evusheld (preventive) &
2022-11-19 00:57:33 The BQ.1.1 variant, as compared with many of the other new variants, is resistant to all clinically used monoclonal antibodies. BQ.1/BQ.1.1 are now the dominant variants in the United States https://t.co/PCFPSGF2uy @TheLancetInfDis https://t.co/dHucxoGokC
2022-11-18 21:17:45 Good news: 1st drug to alter the course of Type 1 diabetes in 100 years approved by @US_FDA Bad news: it costs ~$200,000/14-day treatment
2022-11-18 20:40:04 @legalnomads BA.1 bivalent induces about half as much neutralizing antibodies vs BA.5 as the BA.5 bivalent (live virus assays), both better than original booster. Whether that translates to any difference clinically is unclear.
2022-11-18 20:12:01 The bivalent BA.1 booster is being use in many countries around the world, but data are limited compared with the original (WT) booster against BA.5. New today: doubling of neutralizing antibodies https://t.co/M2YUB5wpH4 (BA.5 bivalent was ~3-5X WT in several recent studies) https://t.co/xYwnfcXkm6
2022-11-18 18:44:04 How to improve science discovery and productivity? Not just about money (see graph below): funding fast, bets on talent/people, take risk, think big https://t.co/HEAXu2L87H by @greg_ip w/ @patrickc @tylercowen @pdhsu https://t.co/7O6qplOf9C
2022-11-18 18:01:46 @KMunoz46 Correct. That's why there's no good explanation
2022-11-18 17:44:15 RT @ElinSilveous: “Foreign rivals have raced ahead in approving long-awaited nasal-spray vaccines, including one invented in St. Louis, cre…
2022-11-18 17:27:39 Does going to @NFL games increase risk of Covid? https://t.co/UzghLiDCgT Interesting findings of an association in the 14-21 day postgame period when >
2022-11-18 16:57:29 If you'd like to boost your protection vs BQ.1.1, 2 new studies that back up the bivalent as the way to get that done https://t.co/wAoTyur6be https://t.co/fDF4KEyJAL https://t.co/FiBnQRxlMG
2022-11-18 16:52:03 US Covid genomics
2022-11-18 15:54:32 A systematic review of Covid vaccines for kids age 5 to 11 (30 studies) Effectiveness 75% vs hospitalization
2022-11-18 15:45:27 @TopherSpiro46 @AshishKJha46 I know, Topher. Absolutely no reason for refusal of Congress and failure to fund. Appreciate @ashishkjha's strong advocacy
2022-11-18 14:58:07 An explainer for why the US is not pursuing nasal vaccines. TLDR: there is no good explanation https://t.co/Ih6ypzOva7 by @benjmueller w/ @VirusesImmunity @florian_krammer
2022-11-18 05:38:35 @hola_jonathan Many thanks!
2022-11-18 05:37:46 @amuendelheim Thanks!
2022-11-18 05:10:48 I'll be here until the lights go out........ You can also find me @erictopol@mstdn.social and https://t.co/YllXWa0b4k https://t.co/5rfMlDkCdM
2022-11-18 03:51:13 @lainemartin1 Very appreciative of your note!
2022-11-18 03:33:22 Refers to BQ.1.1 (see blue arrow)
2022-11-18 03:32:12 New data for why a bivalent booster will help: "These data suggest the bivalent BA.4/5 vaccine is more immunogenic than the original ...vaccine against circulating Omicron sublineages, including BQ.1.1 that is becoming prevalent globally." https://t.co/wAoTyur6be Get boosted! https://t.co/j21g0bELIp
2022-11-18 00:42:08 By current variant growth advantage patterns, the next couple of months in the US will be BQ.1.x dominated. Bivalent boosters will help protect
2022-11-18 00:20:49 @WHCOS Nicely put, Ron. Thanks!
2022-11-18 00:20:19 RT @WHCOS: In simpler terms: Go get your new COVID vaccination now.
2022-11-18 00:06:48 What science forgot during the pandemic https://t.co/12ffbs3ZOF by @richardhorton1 @TheLancet https://t.co/aoJSA3dEco
2022-11-17 23:56:45 A new report confirms the immune escape of the BQ.1.1 variant, along with BA.4.6 &
2022-11-17 23:26:54 We still don't have a way to diagnosis chronic traumatic encephalopathy (CTE) in people who are alive, but may be getting closer https://t.co/SftRQR7TWD by @el_belson @NYTSports https://t.co/BTh6oXUxRg
2022-11-17 21:47:06 RT @rowlsmanthorpe: Long covid has wrecked my life It’s bad, very bad. But you knew that already I want to tell you a hopeful story. A st…
2022-11-17 19:37:27 @PraliNoisette I don't see any sign of that https://t.co/e7u7aZCfBZ
2022-11-17 19:12:51 To note https://t.co/y2qdjFrvDR
2022-11-17 19:11:30 75 years later we have chips with >
2022-11-17 18:08:47 BA.5, déjà vu https://t.co/eILO8PxIkY
2022-11-17 17:33:41 RT @linseymarr: You get a 2-for-1 with filtration. It removes virus from the air and PM2.5 that is associated with an increased risk of inf…
2022-11-17 17:28:45 RT @Aiims1742: Important #OpenAccess paper in @Cancer_Cell from @CharlesSwanton &
2022-11-17 17:09:54 Strong evidence that particulate matter air pollution (ambient PM2.5) increases the risk of Covid infection, a systematic analysis https://t.co/RueG44Hk2m @MonashUni https://t.co/kpREoqJVPi
2022-11-17 15:46:50 About 1 in 5 of us have an APOE4 gene variant, the #1 genetic risk factor for Alzheimer's disease. But the mechanism for brain injury was a mystery, now getting unraveled (cholesterol processing by oligodendrocytes) https://t.co/gIpGt0CA28 @nature https://t.co/hbmdpO6R3t https://t.co/4zFZIhUTCI
2022-11-17 01:27:50 @amitsurg Because they do. That's mostly related to the excess of rebound after Paxlovid
2022-11-17 00:58:05 We've (re-)learned a few important lessons from the Paxlovid rebound experience about randomized trials and real world evidence Reviewed here https://t.co/jmT9vIipg9
2022-11-16 19:46:41 The Paxlovid rebound story New data reviewed in the 16 November daily briefing of Ground Truths https://t.co/jmT9vIipg9
2022-11-16 17:48:15 The US Covid death rate (7-day average) drops below 300 for the first time since June 2022. Lowest since pandemic began was 222 in July 2021. https://t.co/Cze8bZgtVr https://t.co/uxGosRY1KO
2022-11-16 17:14:12 Immunotherapy can induce myocarditis but the mechanism has been poorly understood. A new report @nature today supports the culprit auto-antigen role of α-myosin and cytotoxic T-cells directed to it https://t.co/uPRUQBbkVh by @MargaretAxelrod @BalkoLab https://t.co/vWZP1IcW19
2022-11-16 16:37:07 Humidity (indoor, relative) is associated with outcomes of Covid infections, a population-based study in 121 countries https://t.co/dWMmyMfBSL https://t.co/hW7Jq1mhdo
2022-11-16 01:17:21 RT @PeterHotez: Important and well-conducted study by @EricTopol My take: even though rebound is real and significant, in my conversation…
2022-11-15 23:33:25 For the people pointing out that @POTUS, @CDCDirector and Tony Fauci all had Paxlovid rebound, that's why you do prospective, systematic studies. We've learned that "rebound" also occurs without Paxlovid and that anecdotes/twitter are not representative of the real world
2022-11-15 20:14:34 Each participant did rapid antigen testing every other day through day 15, symptom surveys through day 17, and are being followed for 6 months https://t.co/8bDtswdytR
2022-11-15 20:00:32 The event curves for Paxlovid treated compared with controls https://t.co/2ykeOuBUAX
2022-11-15 19:56:25 Our prospective Paxlovid rebound study with controls preprint is posted By symptoms: ~12% rebound (19% Pax vs 7% controls) By positive testing: ~5% rebound (14% Pax vs 9% controls) Much lower than many estimates https://t.co/czeGEYIJvA by @JayPandit @michaelmina_lab @ScrippsRTI
2022-11-15 19:45:43 Foundation #AI models come to science https://t.co/G7Xx31w1Of https://t.co/HNjVOs3J4I
2022-11-15 19:23:17 @Jdrodric12 that's right!
2022-11-15 18:47:56 @SarahWLaurence @ScrippsRTI Thank you!
2022-11-15 18:31:49 On a day when the world has reached about ~8 billion people, it's notable there have been >
2022-11-15 17:10:19 @surrogateexpare @Medscape Included here https://t.co/bugfFk44sh@Medscape Please fix the links
2022-11-15 17:09:38 This post has all the relevant links and review the recent its for protection vs #LongCovid https://t.co/bugfFk44sh
2022-11-15 16:30:20 Paxlovid interactionsA new report claims 14.6% of patients had contraindications to treatment. But most of these meds could have been safely stopped for 5 dayshttps://t.co/FP3o0J0eBzMore on this herehttps://t.co/i3pUyAJlAs @Medscape https://t.co/0tsAf3xUqu
2022-11-15 16:11:35 Start of new waves in South Korea and Japan, having sustained recent BA.5 waves and this variant still accounts for most new casesThe pandemic isn't over https://t.co/DhwWhZ4CJi
2022-11-15 16:01:28 Here's the article. A potential path to preventing brain tissue from dying https://t.co/ODGuD8X8iy
2022-11-15 00:48:03 Today's pandemic briefing on new booster data and the thick soup of new variantshttps://t.co/LA3nl6FxSx
2022-11-14 17:22:13 RT @danrdanny: Excited to see our work on 3-hour genome sequencing highlighted here! If you think this is interesting we have a bench scien…
2022-11-14 17:04:44 The potential for detecting heart dysfunction (ejection fraction <
2022-11-14 14:37:14 RT @EricTopol: Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so m…
2022-11-14 14:28:16 In aggregate, solid evidence that the bivalent booster elicits a strong and broadened neutralizing antibody immune response. Yet, less than 27% of Americans 65+, the have had it and poor uptake across all age groupshttps://t.co/V5Xlj3cKln
2022-11-14 14:28:15 https://t.co/fJbLUdcYJdCoverage @statnews by @matthewherper w/ @SutharLab, whose results were replicated by the new data (Table)
2022-11-14 12:00:01 Moderna BA.5 bivalent booster results announced (via @moderna_tx press release)—largest study to date of >
2022-11-21 03:25:03 @kjhyuijhybh Yes I did that https://t.co/mJyBxYKymV
2022-11-21 03:24:06 @fstults2 https://t.co/mJyBxZ1BoV works
2022-11-21 01:21:26 Tumors also can have fungi within them which can, like (and interact with) bacteria, have functional impact on cancer and its therapy https://t.co/KDWV9XjQzW @CellCellPress https://t.co/72eyqbrMq0
2022-11-21 00:03:11 @steveagee Approved in China, India, Iran Big clinical trial in Mexico A company (Ocugen) has licensed the Bharat Biotech (India, IP from @WUSTL) for the United States but there’s no regulatory guidance by @US_FDA yet for Covid nasal vaccines
2022-11-20 23:46:08 RT @EricTopol: My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SAR…
2022-11-20 23:14:08 @kellyclose Both, Kelly. T1D mostly in young, predominantly T2D overall
2022-11-20 22:12:36 Great to see a big win for @UVA @UVAMensHoops
2022-11-20 19:10:31 https://t.co/N60zU6pExk
2022-11-20 19:10:30 Bacteria within tumors are capable of suppressing the immune response and promoting cancer spread https://t.co/g0WfQOd6lA @nature elegant work by @BullmanLab and @CJohnstonLab1 using spatial genomics https://t.co/K1sAMmpvhS https://t.co/C62S0nwLFR
2022-11-20 18:55:24 The consistent increased risk of diabetes after Covid across all age groups, highest in the first 3 months after infection, from a systematic review of 9 studies, ~40 million people https://t.co/uJ5T3ENGrj https://t.co/GZzZmhDrfH
2022-11-20 18:41:40 No need to dream anymore. This can be done. But it takes will, priority and funding And debunking the delusion that we're done with #SARSCoV2 https://t.co/TrR777xZTI https://t.co/eKHGg7EPtM https://t.co/1ijx5gN79W
2022-11-20 17:54:58 Months ago @VirusesImmunity and I laid out the strong case for nasal vaccines to achieve containment of the virus, breaking the chain of transmission at the individual and population level https://t.co/OujfFxMgU6 @SciImmunology https://t.co/lPGQTC2T1i
2022-11-20 16:23:27 I'm outraged by this pathetic and inexcusable inability for this country to go after nasal and better, durable, variant-proof vaccines https://t.co/u2AErUyYpN https://t.co/CuRQ51q8pi
2022-11-20 16:10:23 The variants accounting for new cases in Japan as of 11 November https://t.co/Tkkh0fwsf9 https://t.co/2JPHxUOxG1
2022-11-20 15:58:24 There's a 2nd BA.5 wave happening in Japan, the country that has best managed the pandemic https://t.co/z68bDAyl3a https://t.co/FTGx5BB1qt
2022-11-20 15:45:21 Why is the outlook favorable when new variants with marked immune evasion and growth advantage have become dominant? https://t.co/DqMJ7LSJZC
2022-11-19 20:21:41 A new and useful perspective on this report @NatRevNeurol https://t.co/wZ9kvh567Q by @alessandro5161 and @andreapilotto https://t.co/cjturtGVq2
2022-11-19 20:00:42 @TheLarvinMewis Thank you!
2022-11-19 19:46:26 My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SARSCoV2 variant with a marked increase in immune evasion not to have induced a wave. https://t.co/DqMJ7LAALu
2022-11-19 15:35:10 Correcting my typo: it's ronna, not rona More on this here @nature by @LizzieGibney https://t.co/Erb4zTYWCl https://t.co/zMGRoGHeTk
2022-11-19 15:20:02 I thought that many bytes should be named helluva but the new name is quetta https://t.co/d77lA6LTc2
2022-11-19 00:57:34 This poses a major concern for immunocompromised who have benefited from Evusheld (preventive) &
2022-11-19 00:57:33 The BQ.1.1 variant, as compared with many of the other new variants, is resistant to all clinically used monoclonal antibodies. BQ.1/BQ.1.1 are now the dominant variants in the United States https://t.co/PCFPSGF2uy @TheLancetInfDis https://t.co/dHucxoGokC
2022-11-18 21:17:45 Good news: 1st drug to alter the course of Type 1 diabetes in 100 years approved by @US_FDA Bad news: it costs ~$200,000/14-day treatment
2022-11-18 20:40:04 @legalnomads BA.1 bivalent induces about half as much neutralizing antibodies vs BA.5 as the BA.5 bivalent (live virus assays), both better than original booster. Whether that translates to any difference clinically is unclear.
2022-11-18 20:12:01 The bivalent BA.1 booster is being use in many countries around the world, but data are limited compared with the original (WT) booster against BA.5. New today: doubling of neutralizing antibodies https://t.co/M2YUB5wpH4 (BA.5 bivalent was ~3-5X WT in several recent studies) https://t.co/xYwnfcXkm6
2022-11-18 18:44:04 How to improve science discovery and productivity? Not just about money (see graph below): funding fast, bets on talent/people, take risk, think big https://t.co/HEAXu2L87H by @greg_ip w/ @patrickc @tylercowen @pdhsu https://t.co/7O6qplOf9C
2022-11-18 18:01:46 @KMunoz46 Correct. That's why there's no good explanation
2022-11-18 17:44:15 RT @ElinSilveous: “Foreign rivals have raced ahead in approving long-awaited nasal-spray vaccines, including one invented in St. Louis, cre…
2022-11-18 17:27:39 Does going to @NFL games increase risk of Covid? https://t.co/UzghLiDCgT Interesting findings of an association in the 14-21 day postgame period when >
2022-11-18 16:57:29 If you'd like to boost your protection vs BQ.1.1, 2 new studies that back up the bivalent as the way to get that done https://t.co/wAoTyur6be https://t.co/fDF4KEyJAL https://t.co/FiBnQRxlMG
2022-11-18 16:52:03 US Covid genomics
2022-11-18 15:54:32 A systematic review of Covid vaccines for kids age 5 to 11 (30 studies) Effectiveness 75% vs hospitalization
2022-11-18 15:45:27 @TopherSpiro46 @AshishKJha46 I know, Topher. Absolutely no reason for refusal of Congress and failure to fund. Appreciate @ashishkjha's strong advocacy
2022-11-18 14:58:07 An explainer for why the US is not pursuing nasal vaccines. TLDR: there is no good explanation https://t.co/Ih6ypzOva7 by @benjmueller w/ @VirusesImmunity @florian_krammer
2022-11-18 05:38:35 @hola_jonathan Many thanks!
2022-11-18 05:37:46 @amuendelheim Thanks!
2022-11-18 05:10:48 I'll be here until the lights go out........ You can also find me @erictopol@mstdn.social and https://t.co/YllXWa0b4k https://t.co/5rfMlDkCdM
2022-11-18 03:51:13 @lainemartin1 Very appreciative of your note!
2022-11-18 03:33:22 Refers to BQ.1.1 (see blue arrow)
2022-11-18 03:32:12 New data for why a bivalent booster will help: "These data suggest the bivalent BA.4/5 vaccine is more immunogenic than the original ...vaccine against circulating Omicron sublineages, including BQ.1.1 that is becoming prevalent globally." https://t.co/wAoTyur6be Get boosted! https://t.co/j21g0bELIp
2022-11-18 00:42:08 By current variant growth advantage patterns, the next couple of months in the US will be BQ.1.x dominated. Bivalent boosters will help protect
2022-11-18 00:20:49 @WHCOS Nicely put, Ron. Thanks!
2022-11-18 00:20:19 RT @WHCOS: In simpler terms: Go get your new COVID vaccination now.
2022-11-18 00:06:48 What science forgot during the pandemic https://t.co/12ffbs3ZOF by @richardhorton1 @TheLancet https://t.co/aoJSA3dEco
2022-11-17 23:56:45 A new report confirms the immune escape of the BQ.1.1 variant, along with BA.4.6 &
2022-11-17 23:26:54 We still don't have a way to diagnosis chronic traumatic encephalopathy (CTE) in people who are alive, but may be getting closer https://t.co/SftRQR7TWD by @el_belson @NYTSports https://t.co/BTh6oXUxRg
2022-11-17 21:47:06 RT @rowlsmanthorpe: Long covid has wrecked my life It’s bad, very bad. But you knew that already I want to tell you a hopeful story. A st…
2022-11-17 19:37:27 @PraliNoisette I don't see any sign of that https://t.co/e7u7aZCfBZ
2022-11-17 19:12:51 To note https://t.co/y2qdjFrvDR
2022-11-17 19:11:30 75 years later we have chips with >
2022-11-17 18:08:47 BA.5, déjà vu https://t.co/eILO8PxIkY
2022-11-17 17:33:41 RT @linseymarr: You get a 2-for-1 with filtration. It removes virus from the air and PM2.5 that is associated with an increased risk of inf…
2022-11-17 17:28:45 RT @Aiims1742: Important #OpenAccess paper in @Cancer_Cell from @CharlesSwanton &
2022-11-17 17:09:54 Strong evidence that particulate matter air pollution (ambient PM2.5) increases the risk of Covid infection, a systematic analysis https://t.co/RueG44Hk2m @MonashUni https://t.co/kpREoqJVPi
2022-11-17 15:46:50 About 1 in 5 of us have an APOE4 gene variant, the #1 genetic risk factor for Alzheimer's disease. But the mechanism for brain injury was a mystery, now getting unraveled (cholesterol processing by oligodendrocytes) https://t.co/gIpGt0CA28 @nature https://t.co/hbmdpO6R3t https://t.co/4zFZIhUTCI
2022-11-17 01:27:50 @amitsurg Because they do. That's mostly related to the excess of rebound after Paxlovid
2022-11-17 00:58:05 We've (re-)learned a few important lessons from the Paxlovid rebound experience about randomized trials and real world evidence Reviewed here https://t.co/jmT9vIipg9
2022-11-16 19:46:41 The Paxlovid rebound story New data reviewed in the 16 November daily briefing of Ground Truths https://t.co/jmT9vIipg9
2022-11-16 17:48:15 The US Covid death rate (7-day average) drops below 300 for the first time since June 2022. Lowest since pandemic began was 222 in July 2021. https://t.co/Cze8bZgtVr https://t.co/uxGosRY1KO
2022-11-16 17:14:12 Immunotherapy can induce myocarditis but the mechanism has been poorly understood. A new report @nature today supports the culprit auto-antigen role of α-myosin and cytotoxic T-cells directed to it https://t.co/uPRUQBbkVh by @MargaretAxelrod @BalkoLab https://t.co/vWZP1IcW19
2022-11-16 16:37:07 Humidity (indoor, relative) is associated with outcomes of Covid infections, a population-based study in 121 countries https://t.co/dWMmyMfBSL https://t.co/hW7Jq1mhdo
2022-11-16 01:17:21 RT @PeterHotez: Important and well-conducted study by @EricTopol My take: even though rebound is real and significant, in my conversation…
2022-11-15 23:33:25 For the people pointing out that @POTUS, @CDCDirector and Tony Fauci all had Paxlovid rebound, that's why you do prospective, systematic studies. We've learned that "rebound" also occurs without Paxlovid and that anecdotes/twitter are not representative of the real world
2022-11-15 20:14:34 Each participant did rapid antigen testing every other day through day 15, symptom surveys through day 17, and are being followed for 6 months https://t.co/8bDtswdytR
2022-11-15 20:00:32 The event curves for Paxlovid treated compared with controls https://t.co/2ykeOuBUAX
2022-11-15 19:56:25 Our prospective Paxlovid rebound study with controls preprint is posted By symptoms: ~12% rebound (19% Pax vs 7% controls) By positive testing: ~5% rebound (14% Pax vs 9% controls) Much lower than many estimates https://t.co/czeGEYIJvA by @JayPandit @michaelmina_lab @ScrippsRTI
2022-11-15 19:45:43 Foundation #AI models come to science https://t.co/G7Xx31w1Of https://t.co/HNjVOs3J4I
2022-11-15 19:23:17 @Jdrodric12 that's right!
2022-11-15 18:47:56 @SarahWLaurence @ScrippsRTI Thank you!
2022-11-15 18:31:49 On a day when the world has reached about ~8 billion people, it's notable there have been >
2022-11-15 17:10:19 @surrogateexpare @Medscape Included here https://t.co/bugfFk44sh@Medscape Please fix the links
2022-11-15 17:09:38 This post has all the relevant links and review the recent its for protection vs #LongCovid https://t.co/bugfFk44sh
2022-11-15 16:30:20 Paxlovid interactionsA new report claims 14.6% of patients had contraindications to treatment. But most of these meds could have been safely stopped for 5 dayshttps://t.co/FP3o0J0eBzMore on this herehttps://t.co/i3pUyAJlAs @Medscape https://t.co/0tsAf3xUqu
2022-11-15 16:11:35 Start of new waves in South Korea and Japan, having sustained recent BA.5 waves and this variant still accounts for most new casesThe pandemic isn't over https://t.co/DhwWhZ4CJi
2022-11-15 16:01:28 Here's the article. A potential path to preventing brain tissue from dying https://t.co/ODGuD8X8iy
2022-11-15 00:48:03 Today's pandemic briefing on new booster data and the thick soup of new variantshttps://t.co/LA3nl6FxSx
2022-11-14 17:22:13 RT @danrdanny: Excited to see our work on 3-hour genome sequencing highlighted here! If you think this is interesting we have a bench scien…
2022-11-14 17:04:44 The potential for detecting heart dysfunction (ejection fraction <
2022-11-14 14:37:14 RT @EricTopol: Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so m…
2022-11-14 14:28:16 In aggregate, solid evidence that the bivalent booster elicits a strong and broadened neutralizing antibody immune response. Yet, less than 27% of Americans 65+, the have had it and poor uptake across all age groupshttps://t.co/V5Xlj3cKln
2022-11-14 14:28:15 https://t.co/fJbLUdcYJdCoverage @statnews by @matthewherper w/ @SutharLab, whose results were replicated by the new data (Table)
2022-11-14 12:00:01 Moderna BA.5 bivalent booster results announced (via @moderna_tx press release)—largest study to date of >
2022-11-21 16:14:51 As of 10 November 2022, it is estimated that 94% of Americans have had Covid at least once, much of those infections in the past year. Ranking of states w/ most vulnerability d/t lack of vaccines/ boosters https://t.co/W5zzyrD0vN @HarvardChanSPH https://t.co/FlY9MqC3Jq
2022-11-21 14:55:09 Unlike the prior 2 holiday seasons in the US, a major surge is unlikely, which is not in keeping with new, dominant variants with marked immune evasion. https://t.co/DqMJ7LAALu However, waning of immunity, poor uptake of boosters, and lack of mitigation sets up vulnerability https://t.co/rEQSBzeewg
2022-11-21 14:38:35 Encouraging new data for @Novavax boosters (1st and 2nd) for inducing neutralizing antibody response vs BA.5 https://t.co/CmpPueCwuG https://t.co/sbeWpljL7e
2022-11-21 14:28:55 Myocarditis after mRNA Covid vaccines: results from over 10 million doses in British Columbia https://t.co/CrnzxyPSDX @CMAJ https://t.co/y4rcdcJS67
2022-11-21 03:25:03 @kjhyuijhybh Yes I did that https://t.co/mJyBxYKymV
2022-11-21 03:24:06 @fstults2 https://t.co/mJyBxZ1BoV works
2022-11-21 01:21:26 Tumors also can have fungi within them which can, like (and interact with) bacteria, have functional impact on cancer and its therapy https://t.co/KDWV9XjQzW @CellCellPress https://t.co/72eyqbrMq0
2022-11-21 00:03:11 @steveagee Approved in China, India, Iran Big clinical trial in Mexico A company (Ocugen) has licensed the Bharat Biotech (India, IP from @WUSTL) for the United States but there’s no regulatory guidance by @US_FDA yet for Covid nasal vaccines
2022-11-20 23:46:08 RT @EricTopol: My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SAR…
2022-11-20 23:14:08 @kellyclose Both, Kelly. T1D mostly in young, predominantly T2D overall
2022-11-20 22:12:36 Great to see a big win for @UVA @UVAMensHoops
2022-11-20 19:10:31 https://t.co/N60zU6pExk
2022-11-20 19:10:30 Bacteria within tumors are capable of suppressing the immune response and promoting cancer spread https://t.co/g0WfQOd6lA @nature elegant work by @BullmanLab and @CJohnstonLab1 using spatial genomics https://t.co/K1sAMmpvhS https://t.co/C62S0nwLFR
2022-11-20 18:55:24 The consistent increased risk of diabetes after Covid across all age groups, highest in the first 3 months after infection, from a systematic review of 9 studies, ~40 million people https://t.co/uJ5T3ENGrj https://t.co/GZzZmhDrfH
2022-11-20 18:41:40 No need to dream anymore. This can be done. But it takes will, priority and funding And debunking the delusion that we're done with #SARSCoV2 https://t.co/TrR777xZTI https://t.co/eKHGg7EPtM https://t.co/1ijx5gN79W
2022-11-20 17:54:58 Months ago @VirusesImmunity and I laid out the strong case for nasal vaccines to achieve containment of the virus, breaking the chain of transmission at the individual and population level https://t.co/OujfFxMgU6 @SciImmunology https://t.co/lPGQTC2T1i
2022-11-20 16:23:27 I'm outraged by this pathetic and inexcusable inability for this country to go after nasal and better, durable, variant-proof vaccines https://t.co/u2AErUyYpN https://t.co/CuRQ51q8pi
2022-11-20 16:10:23 The variants accounting for new cases in Japan as of 11 November https://t.co/Tkkh0fwsf9 https://t.co/2JPHxUOxG1
2022-11-20 15:58:24 There's a 2nd BA.5 wave happening in Japan, the country that has best managed the pandemic https://t.co/z68bDAyl3a https://t.co/FTGx5BB1qt
2022-11-20 15:45:21 Why is the outlook favorable when new variants with marked immune evasion and growth advantage have become dominant? https://t.co/DqMJ7LSJZC
2022-11-19 20:21:41 A new and useful perspective on this report @NatRevNeurol https://t.co/wZ9kvh567Q by @alessandro5161 and @andreapilotto https://t.co/cjturtGVq2
2022-11-19 20:00:42 @TheLarvinMewis Thank you!
2022-11-19 19:46:26 My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SARSCoV2 variant with a marked increase in immune evasion not to have induced a wave. https://t.co/DqMJ7LAALu
2022-11-19 15:35:10 Correcting my typo: it's ronna, not rona More on this here @nature by @LizzieGibney https://t.co/Erb4zTYWCl https://t.co/zMGRoGHeTk
2022-11-19 15:20:02 I thought that many bytes should be named helluva but the new name is quetta https://t.co/d77lA6LTc2
2022-11-19 00:57:34 This poses a major concern for immunocompromised who have benefited from Evusheld (preventive) &
2022-11-19 00:57:33 The BQ.1.1 variant, as compared with many of the other new variants, is resistant to all clinically used monoclonal antibodies. BQ.1/BQ.1.1 are now the dominant variants in the United States https://t.co/PCFPSGF2uy @TheLancetInfDis https://t.co/dHucxoGokC
2022-11-18 21:17:45 Good news: 1st drug to alter the course of Type 1 diabetes in 100 years approved by @US_FDA Bad news: it costs ~$200,000/14-day treatment
2022-11-18 20:40:04 @legalnomads BA.1 bivalent induces about half as much neutralizing antibodies vs BA.5 as the BA.5 bivalent (live virus assays), both better than original booster. Whether that translates to any difference clinically is unclear.
2022-11-18 20:12:01 The bivalent BA.1 booster is being use in many countries around the world, but data are limited compared with the original (WT) booster against BA.5. New today: doubling of neutralizing antibodies https://t.co/M2YUB5wpH4 (BA.5 bivalent was ~3-5X WT in several recent studies) https://t.co/xYwnfcXkm6
2022-11-18 18:44:04 How to improve science discovery and productivity? Not just about money (see graph below): funding fast, bets on talent/people, take risk, think big https://t.co/HEAXu2L87H by @greg_ip w/ @patrickc @tylercowen @pdhsu https://t.co/7O6qplOf9C
2022-11-18 18:01:46 @KMunoz46 Correct. That's why there's no good explanation
2022-11-18 17:44:15 RT @ElinSilveous: “Foreign rivals have raced ahead in approving long-awaited nasal-spray vaccines, including one invented in St. Louis, cre…
2022-11-18 17:27:39 Does going to @NFL games increase risk of Covid? https://t.co/UzghLiDCgT Interesting findings of an association in the 14-21 day postgame period when >
2022-11-18 16:57:29 If you'd like to boost your protection vs BQ.1.1, 2 new studies that back up the bivalent as the way to get that done https://t.co/wAoTyur6be https://t.co/fDF4KEyJAL https://t.co/FiBnQRxlMG
2022-11-18 16:52:03 US Covid genomics
2022-11-18 15:54:32 A systematic review of Covid vaccines for kids age 5 to 11 (30 studies) Effectiveness 75% vs hospitalization
2022-11-18 15:45:27 @TopherSpiro46 @AshishKJha46 I know, Topher. Absolutely no reason for refusal of Congress and failure to fund. Appreciate @ashishkjha's strong advocacy
2022-11-18 14:58:07 An explainer for why the US is not pursuing nasal vaccines. TLDR: there is no good explanation https://t.co/Ih6ypzOva7 by @benjmueller w/ @VirusesImmunity @florian_krammer
2022-11-18 05:38:35 @hola_jonathan Many thanks!
2022-11-18 05:37:46 @amuendelheim Thanks!
2022-11-18 05:10:48 I'll be here until the lights go out........ You can also find me @erictopol@mstdn.social and https://t.co/YllXWa0b4k https://t.co/5rfMlDkCdM
2022-11-18 03:51:13 @lainemartin1 Very appreciative of your note!
2022-11-18 03:33:22 Refers to BQ.1.1 (see blue arrow)
2022-11-18 03:32:12 New data for why a bivalent booster will help: "These data suggest the bivalent BA.4/5 vaccine is more immunogenic than the original ...vaccine against circulating Omicron sublineages, including BQ.1.1 that is becoming prevalent globally." https://t.co/wAoTyur6be Get boosted! https://t.co/j21g0bELIp
2022-11-18 00:42:08 By current variant growth advantage patterns, the next couple of months in the US will be BQ.1.x dominated. Bivalent boosters will help protect
2022-11-18 00:20:49 @WHCOS Nicely put, Ron. Thanks!
2022-11-18 00:20:19 RT @WHCOS: In simpler terms: Go get your new COVID vaccination now.
2022-11-18 00:06:48 What science forgot during the pandemic https://t.co/12ffbs3ZOF by @richardhorton1 @TheLancet https://t.co/aoJSA3dEco
2022-11-17 23:56:45 A new report confirms the immune escape of the BQ.1.1 variant, along with BA.4.6 &
2022-11-17 23:26:54 We still don't have a way to diagnosis chronic traumatic encephalopathy (CTE) in people who are alive, but may be getting closer https://t.co/SftRQR7TWD by @el_belson @NYTSports https://t.co/BTh6oXUxRg
2022-11-17 21:47:06 RT @rowlsmanthorpe: Long covid has wrecked my life It’s bad, very bad. But you knew that already I want to tell you a hopeful story. A st…
2022-11-17 19:37:27 @PraliNoisette I don't see any sign of that https://t.co/e7u7aZCfBZ
2022-11-17 19:12:51 To note https://t.co/y2qdjFrvDR
2022-11-17 19:11:30 75 years later we have chips with >
2022-11-17 18:08:47 BA.5, déjà vu https://t.co/eILO8PxIkY
2022-11-17 17:33:41 RT @linseymarr: You get a 2-for-1 with filtration. It removes virus from the air and PM2.5 that is associated with an increased risk of inf…
2022-11-17 17:28:45 RT @Aiims1742: Important #OpenAccess paper in @Cancer_Cell from @CharlesSwanton &
2022-11-17 17:09:54 Strong evidence that particulate matter air pollution (ambient PM2.5) increases the risk of Covid infection, a systematic analysis https://t.co/RueG44Hk2m @MonashUni https://t.co/kpREoqJVPi
2022-11-17 15:46:50 About 1 in 5 of us have an APOE4 gene variant, the #1 genetic risk factor for Alzheimer's disease. But the mechanism for brain injury was a mystery, now getting unraveled (cholesterol processing by oligodendrocytes) https://t.co/gIpGt0CA28 @nature https://t.co/hbmdpO6R3t https://t.co/4zFZIhUTCI
2022-11-17 01:27:50 @amitsurg Because they do. That's mostly related to the excess of rebound after Paxlovid
2022-11-17 00:58:05 We've (re-)learned a few important lessons from the Paxlovid rebound experience about randomized trials and real world evidence Reviewed here https://t.co/jmT9vIipg9
2022-11-16 19:46:41 The Paxlovid rebound story New data reviewed in the 16 November daily briefing of Ground Truths https://t.co/jmT9vIipg9
2022-11-16 17:48:15 The US Covid death rate (7-day average) drops below 300 for the first time since June 2022. Lowest since pandemic began was 222 in July 2021. https://t.co/Cze8bZgtVr https://t.co/uxGosRY1KO
2022-11-16 17:14:12 Immunotherapy can induce myocarditis but the mechanism has been poorly understood. A new report @nature today supports the culprit auto-antigen role of α-myosin and cytotoxic T-cells directed to it https://t.co/uPRUQBbkVh by @MargaretAxelrod @BalkoLab https://t.co/vWZP1IcW19
2022-11-16 16:37:07 Humidity (indoor, relative) is associated with outcomes of Covid infections, a population-based study in 121 countries https://t.co/dWMmyMfBSL https://t.co/hW7Jq1mhdo
2022-11-16 01:17:21 RT @PeterHotez: Important and well-conducted study by @EricTopol My take: even though rebound is real and significant, in my conversation…
2022-11-15 23:33:25 For the people pointing out that @POTUS, @CDCDirector and Tony Fauci all had Paxlovid rebound, that's why you do prospective, systematic studies. We've learned that "rebound" also occurs without Paxlovid and that anecdotes/twitter are not representative of the real world
2022-11-15 20:14:34 Each participant did rapid antigen testing every other day through day 15, symptom surveys through day 17, and are being followed for 6 months https://t.co/8bDtswdytR
2022-11-15 20:00:32 The event curves for Paxlovid treated compared with controls https://t.co/2ykeOuBUAX
2022-11-15 19:56:25 Our prospective Paxlovid rebound study with controls preprint is posted By symptoms: ~12% rebound (19% Pax vs 7% controls) By positive testing: ~5% rebound (14% Pax vs 9% controls) Much lower than many estimates https://t.co/czeGEYIJvA by @JayPandit @michaelmina_lab @ScrippsRTI
2022-11-15 19:45:43 Foundation #AI models come to science https://t.co/G7Xx31w1Of https://t.co/HNjVOs3J4I
2022-11-15 19:23:17 @Jdrodric12 that's right!
2022-11-15 18:47:56 @SarahWLaurence @ScrippsRTI Thank you!
2022-11-15 18:31:49 On a day when the world has reached about ~8 billion people, it's notable there have been >
2022-11-15 17:10:19 @surrogateexpare @Medscape Included here https://t.co/bugfFk44sh@Medscape Please fix the links
2022-11-15 17:09:38 This post has all the relevant links and review the recent its for protection vs #LongCovid https://t.co/bugfFk44sh
2022-11-15 16:30:20 Paxlovid interactionsA new report claims 14.6% of patients had contraindications to treatment. But most of these meds could have been safely stopped for 5 dayshttps://t.co/FP3o0J0eBzMore on this herehttps://t.co/i3pUyAJlAs @Medscape https://t.co/0tsAf3xUqu
2022-11-15 16:11:35 Start of new waves in South Korea and Japan, having sustained recent BA.5 waves and this variant still accounts for most new casesThe pandemic isn't over https://t.co/DhwWhZ4CJi
2022-11-15 16:01:28 Here's the article. A potential path to preventing brain tissue from dying https://t.co/ODGuD8X8iy
2022-11-15 00:48:03 Today's pandemic briefing on new booster data and the thick soup of new variantshttps://t.co/LA3nl6FxSx
2022-11-14 17:22:13 RT @danrdanny: Excited to see our work on 3-hour genome sequencing highlighted here! If you think this is interesting we have a bench scien…
2022-11-14 17:04:44 The potential for detecting heart dysfunction (ejection fraction <
2022-11-14 14:37:14 RT @EricTopol: Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so m…
2022-11-14 14:28:16 In aggregate, solid evidence that the bivalent booster elicits a strong and broadened neutralizing antibody immune response. Yet, less than 27% of Americans 65+, the have had it and poor uptake across all age groupshttps://t.co/V5Xlj3cKln
2022-11-14 14:28:15 https://t.co/fJbLUdcYJdCoverage @statnews by @matthewherper w/ @SutharLab, whose results were replicated by the new data (Table)
2022-11-14 12:00:01 Moderna BA.5 bivalent booster results announced (via @moderna_tx press release)—largest study to date of >
2022-11-22 23:11:25 In synch with the hopeful tone https://t.co/uliFt9RZTS https://t.co/tHHLSvHdfg
2022-11-22 20:53:31 Vaccine effectiveness vs reinfection, a Denmark nationwide study The reduction of reinfection after primary vaccination was significant for the Alpha, Delta, and Omicron variant periods, ranging from 60-94%, lasting up to 9 months https://t.co/C9gWMfC1Tc @PLOSMedicine https://t.co/5VZq1Hgwk2
2022-11-22 20:46:42 Illuminating new @CDCMMWR repot for real world Paxlovid reduction of hospitalization by ~50% across all subgroups by age, vaccinated status, prior infection, month of infection (proxy for variant) https://t.co/LoMLSPepmd https://t.co/oLNscrf5M4
2022-11-22 20:05:09 New @CDCgov data for reduction of deaths by vaccination/boosters for age 12+ through September 2022 https://t.co/HGyjNwCm0v https://t.co/zo345UNZgb
2022-11-22 16:19:46 “Americans have been trained for 100 years to think that the hospital is the best place to be, the safest place. But we have strong evidence that the outcomes are actually better at home.” The hospital-at-home movement is just getting started https://t.co/TnfDzSCeoK @paula_span https://t.co/tvxqFMqwE5
2022-11-22 16:07:48 Our digital times :-) by @speedbumpcomic https://t.co/owtpzW5NqN
2022-11-21 16:14:51 As of 10 November 2022, it is estimated that 94% of Americans have had Covid at least once, much of those infections in the past year. Ranking of states w/ most vulnerability d/t lack of vaccines/ boosters https://t.co/W5zzyrD0vN @HarvardChanSPH https://t.co/FlY9MqC3Jq
2022-11-21 14:55:09 Unlike the prior 2 holiday seasons in the US, a major surge is unlikely, which is not in keeping with new, dominant variants with marked immune evasion. https://t.co/DqMJ7LAALu However, waning of immunity, poor uptake of boosters, and lack of mitigation sets up vulnerability https://t.co/rEQSBzeewg
2022-11-21 14:38:35 Encouraging new data for @Novavax boosters (1st and 2nd) for inducing neutralizing antibody response vs BA.5 https://t.co/CmpPueCwuG https://t.co/sbeWpljL7e
2022-11-21 14:28:55 Myocarditis after mRNA Covid vaccines: results from over 10 million doses in British Columbia https://t.co/CrnzxyPSDX @CMAJ https://t.co/y4rcdcJS67
2022-11-21 03:25:03 @kjhyuijhybh Yes I did that https://t.co/mJyBxYKymV
2022-11-21 03:24:06 @fstults2 https://t.co/mJyBxZ1BoV works
2022-11-21 01:21:26 Tumors also can have fungi within them which can, like (and interact with) bacteria, have functional impact on cancer and its therapy https://t.co/KDWV9XjQzW @CellCellPress https://t.co/72eyqbrMq0
2022-11-21 00:03:11 @steveagee Approved in China, India, Iran Big clinical trial in Mexico A company (Ocugen) has licensed the Bharat Biotech (India, IP from @WUSTL) for the United States but there’s no regulatory guidance by @US_FDA yet for Covid nasal vaccines
2022-11-20 23:46:08 RT @EricTopol: My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SAR…
2022-11-20 23:14:08 @kellyclose Both, Kelly. T1D mostly in young, predominantly T2D overall
2022-11-20 22:12:36 Great to see a big win for @UVA @UVAMensHoops
2022-11-20 19:10:31 https://t.co/N60zU6pExk
2022-11-20 19:10:30 Bacteria within tumors are capable of suppressing the immune response and promoting cancer spread https://t.co/g0WfQOd6lA @nature elegant work by @BullmanLab and @CJohnstonLab1 using spatial genomics https://t.co/K1sAMmpvhS https://t.co/C62S0nwLFR
2022-11-20 18:55:24 The consistent increased risk of diabetes after Covid across all age groups, highest in the first 3 months after infection, from a systematic review of 9 studies, ~40 million people https://t.co/uJ5T3ENGrj https://t.co/GZzZmhDrfH
2022-11-20 18:41:40 No need to dream anymore. This can be done. But it takes will, priority and funding And debunking the delusion that we're done with #SARSCoV2 https://t.co/TrR777xZTI https://t.co/eKHGg7EPtM https://t.co/1ijx5gN79W
2022-11-20 17:54:58 Months ago @VirusesImmunity and I laid out the strong case for nasal vaccines to achieve containment of the virus, breaking the chain of transmission at the individual and population level https://t.co/OujfFxMgU6 @SciImmunology https://t.co/lPGQTC2T1i
2022-11-20 16:23:27 I'm outraged by this pathetic and inexcusable inability for this country to go after nasal and better, durable, variant-proof vaccines https://t.co/u2AErUyYpN https://t.co/CuRQ51q8pi
2022-11-20 16:10:23 The variants accounting for new cases in Japan as of 11 November https://t.co/Tkkh0fwsf9 https://t.co/2JPHxUOxG1
2022-11-20 15:58:24 There's a 2nd BA.5 wave happening in Japan, the country that has best managed the pandemic https://t.co/z68bDAyl3a https://t.co/FTGx5BB1qt
2022-11-20 15:45:21 Why is the outlook favorable when new variants with marked immune evasion and growth advantage have become dominant? https://t.co/DqMJ7LSJZC
2022-11-19 20:21:41 A new and useful perspective on this report @NatRevNeurol https://t.co/wZ9kvh567Q by @alessandro5161 and @andreapilotto https://t.co/cjturtGVq2
2022-11-19 20:00:42 @TheLarvinMewis Thank you!
2022-11-19 19:46:26 My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SARSCoV2 variant with a marked increase in immune evasion not to have induced a wave. https://t.co/DqMJ7LAALu
2022-11-19 15:35:10 Correcting my typo: it's ronna, not rona More on this here @nature by @LizzieGibney https://t.co/Erb4zTYWCl https://t.co/zMGRoGHeTk
2022-11-19 15:20:02 I thought that many bytes should be named helluva but the new name is quetta https://t.co/d77lA6LTc2
2022-11-19 00:57:34 This poses a major concern for immunocompromised who have benefited from Evusheld (preventive) &
2022-11-19 00:57:33 The BQ.1.1 variant, as compared with many of the other new variants, is resistant to all clinically used monoclonal antibodies. BQ.1/BQ.1.1 are now the dominant variants in the United States https://t.co/PCFPSGF2uy @TheLancetInfDis https://t.co/dHucxoGokC
2022-11-18 21:17:45 Good news: 1st drug to alter the course of Type 1 diabetes in 100 years approved by @US_FDA Bad news: it costs ~$200,000/14-day treatment
2022-11-18 20:40:04 @legalnomads BA.1 bivalent induces about half as much neutralizing antibodies vs BA.5 as the BA.5 bivalent (live virus assays), both better than original booster. Whether that translates to any difference clinically is unclear.
2022-11-18 20:12:01 The bivalent BA.1 booster is being use in many countries around the world, but data are limited compared with the original (WT) booster against BA.5. New today: doubling of neutralizing antibodies https://t.co/M2YUB5wpH4 (BA.5 bivalent was ~3-5X WT in several recent studies) https://t.co/xYwnfcXkm6
2022-11-18 18:44:04 How to improve science discovery and productivity? Not just about money (see graph below): funding fast, bets on talent/people, take risk, think big https://t.co/HEAXu2L87H by @greg_ip w/ @patrickc @tylercowen @pdhsu https://t.co/7O6qplOf9C
2022-11-18 18:01:46 @KMunoz46 Correct. That's why there's no good explanation
2022-11-18 17:44:15 RT @ElinSilveous: “Foreign rivals have raced ahead in approving long-awaited nasal-spray vaccines, including one invented in St. Louis, cre…
2022-11-18 17:27:39 Does going to @NFL games increase risk of Covid? https://t.co/UzghLiDCgT Interesting findings of an association in the 14-21 day postgame period when >
2022-11-18 16:57:29 If you'd like to boost your protection vs BQ.1.1, 2 new studies that back up the bivalent as the way to get that done https://t.co/wAoTyur6be https://t.co/fDF4KEyJAL https://t.co/FiBnQRxlMG
2022-11-18 16:52:03 US Covid genomics
2022-11-18 15:54:32 A systematic review of Covid vaccines for kids age 5 to 11 (30 studies) Effectiveness 75% vs hospitalization
2022-11-18 15:45:27 @TopherSpiro46 @AshishKJha46 I know, Topher. Absolutely no reason for refusal of Congress and failure to fund. Appreciate @ashishkjha's strong advocacy
2022-11-18 14:58:07 An explainer for why the US is not pursuing nasal vaccines. TLDR: there is no good explanation https://t.co/Ih6ypzOva7 by @benjmueller w/ @VirusesImmunity @florian_krammer
2022-11-18 05:38:35 @hola_jonathan Many thanks!
2022-11-18 05:37:46 @amuendelheim Thanks!
2022-11-18 05:10:48 I'll be here until the lights go out........ You can also find me @erictopol@mstdn.social and https://t.co/YllXWa0b4k https://t.co/5rfMlDkCdM
2022-11-18 03:51:13 @lainemartin1 Very appreciative of your note!
2022-11-18 03:33:22 Refers to BQ.1.1 (see blue arrow)
2022-11-18 03:32:12 New data for why a bivalent booster will help: "These data suggest the bivalent BA.4/5 vaccine is more immunogenic than the original ...vaccine against circulating Omicron sublineages, including BQ.1.1 that is becoming prevalent globally." https://t.co/wAoTyur6be Get boosted! https://t.co/j21g0bELIp
2022-11-18 00:42:08 By current variant growth advantage patterns, the next couple of months in the US will be BQ.1.x dominated. Bivalent boosters will help protect
2022-11-18 00:20:49 @WHCOS Nicely put, Ron. Thanks!
2022-11-18 00:20:19 RT @WHCOS: In simpler terms: Go get your new COVID vaccination now.
2022-11-18 00:06:48 What science forgot during the pandemic https://t.co/12ffbs3ZOF by @richardhorton1 @TheLancet https://t.co/aoJSA3dEco
2022-11-17 23:56:45 A new report confirms the immune escape of the BQ.1.1 variant, along with BA.4.6 &
2022-11-17 23:26:54 We still don't have a way to diagnosis chronic traumatic encephalopathy (CTE) in people who are alive, but may be getting closer https://t.co/SftRQR7TWD by @el_belson @NYTSports https://t.co/BTh6oXUxRg
2022-11-17 21:47:06 RT @rowlsmanthorpe: Long covid has wrecked my life It’s bad, very bad. But you knew that already I want to tell you a hopeful story. A st…
2022-11-17 19:37:27 @PraliNoisette I don't see any sign of that https://t.co/e7u7aZCfBZ
2022-11-17 19:12:51 To note https://t.co/y2qdjFrvDR
2022-11-17 19:11:30 75 years later we have chips with >
2022-11-17 18:08:47 BA.5, déjà vu https://t.co/eILO8PxIkY
2022-11-17 17:33:41 RT @linseymarr: You get a 2-for-1 with filtration. It removes virus from the air and PM2.5 that is associated with an increased risk of inf…
2022-11-17 17:28:45 RT @Aiims1742: Important #OpenAccess paper in @Cancer_Cell from @CharlesSwanton &
2022-11-17 17:09:54 Strong evidence that particulate matter air pollution (ambient PM2.5) increases the risk of Covid infection, a systematic analysis https://t.co/RueG44Hk2m @MonashUni https://t.co/kpREoqJVPi
2022-11-17 15:46:50 About 1 in 5 of us have an APOE4 gene variant, the #1 genetic risk factor for Alzheimer's disease. But the mechanism for brain injury was a mystery, now getting unraveled (cholesterol processing by oligodendrocytes) https://t.co/gIpGt0CA28 @nature https://t.co/hbmdpO6R3t https://t.co/4zFZIhUTCI
2022-11-17 01:27:50 @amitsurg Because they do. That's mostly related to the excess of rebound after Paxlovid
2022-11-17 00:58:05 We've (re-)learned a few important lessons from the Paxlovid rebound experience about randomized trials and real world evidence Reviewed here https://t.co/jmT9vIipg9
2022-11-16 19:46:41 The Paxlovid rebound story New data reviewed in the 16 November daily briefing of Ground Truths https://t.co/jmT9vIipg9
2022-11-16 17:48:15 The US Covid death rate (7-day average) drops below 300 for the first time since June 2022. Lowest since pandemic began was 222 in July 2021. https://t.co/Cze8bZgtVr https://t.co/uxGosRY1KO
2022-11-16 17:14:12 Immunotherapy can induce myocarditis but the mechanism has been poorly understood. A new report @nature today supports the culprit auto-antigen role of α-myosin and cytotoxic T-cells directed to it https://t.co/uPRUQBbkVh by @MargaretAxelrod @BalkoLab https://t.co/vWZP1IcW19
2022-11-16 16:37:07 Humidity (indoor, relative) is associated with outcomes of Covid infections, a population-based study in 121 countries https://t.co/dWMmyMfBSL https://t.co/hW7Jq1mhdo
2022-11-16 01:17:21 RT @PeterHotez: Important and well-conducted study by @EricTopol My take: even though rebound is real and significant, in my conversation…
2022-11-15 23:33:25 For the people pointing out that @POTUS, @CDCDirector and Tony Fauci all had Paxlovid rebound, that's why you do prospective, systematic studies. We've learned that "rebound" also occurs without Paxlovid and that anecdotes/twitter are not representative of the real world
2022-11-15 20:14:34 Each participant did rapid antigen testing every other day through day 15, symptom surveys through day 17, and are being followed for 6 months https://t.co/8bDtswdytR
2022-11-15 20:00:32 The event curves for Paxlovid treated compared with controls https://t.co/2ykeOuBUAX
2022-11-15 19:56:25 Our prospective Paxlovid rebound study with controls preprint is posted By symptoms: ~12% rebound (19% Pax vs 7% controls) By positive testing: ~5% rebound (14% Pax vs 9% controls) Much lower than many estimates https://t.co/czeGEYIJvA by @JayPandit @michaelmina_lab @ScrippsRTI
2022-11-15 19:45:43 Foundation #AI models come to science https://t.co/G7Xx31w1Of https://t.co/HNjVOs3J4I
2022-11-15 19:23:17 @Jdrodric12 that's right!
2022-11-15 18:47:56 @SarahWLaurence @ScrippsRTI Thank you!
2022-11-15 18:31:49 On a day when the world has reached about ~8 billion people, it's notable there have been >
2022-11-15 17:10:19 @surrogateexpare @Medscape Included here https://t.co/bugfFk44sh@Medscape Please fix the links
2022-11-15 17:09:38 This post has all the relevant links and review the recent its for protection vs #LongCovid https://t.co/bugfFk44sh
2022-11-15 16:30:20 Paxlovid interactionsA new report claims 14.6% of patients had contraindications to treatment. But most of these meds could have been safely stopped for 5 dayshttps://t.co/FP3o0J0eBzMore on this herehttps://t.co/i3pUyAJlAs @Medscape https://t.co/0tsAf3xUqu
2022-11-15 16:11:35 Start of new waves in South Korea and Japan, having sustained recent BA.5 waves and this variant still accounts for most new casesThe pandemic isn't over https://t.co/DhwWhZ4CJi
2022-11-15 16:01:28 Here's the article. A potential path to preventing brain tissue from dying https://t.co/ODGuD8X8iy
2022-11-15 00:48:03 Today's pandemic briefing on new booster data and the thick soup of new variantshttps://t.co/LA3nl6FxSx
2022-11-14 17:22:13 RT @danrdanny: Excited to see our work on 3-hour genome sequencing highlighted here! If you think this is interesting we have a bench scien…
2022-11-14 17:04:44 The potential for detecting heart dysfunction (ejection fraction <
2022-11-14 14:37:14 RT @EricTopol: Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so m…
2022-11-14 14:28:16 In aggregate, solid evidence that the bivalent booster elicits a strong and broadened neutralizing antibody immune response. Yet, less than 27% of Americans 65+, the have had it and poor uptake across all age groupshttps://t.co/V5Xlj3cKln
2022-11-14 14:28:15 https://t.co/fJbLUdcYJdCoverage @statnews by @matthewherper w/ @SutharLab, whose results were replicated by the new data (Table)
2022-11-14 12:00:01 Moderna BA.5 bivalent booster results announced (via @moderna_tx press release)—largest study to date of >
2022-11-24 19:58:48 The growing body of evidence that the 3 respiratory viruses (Covid, flu, RSV) interfere with each other’s spread, limiting a tripledemic's threat https://t.co/auPadYfbsa @ScienceMagazine by @sciencecohen https://t.co/yUKqrZyNUW
2022-11-24 19:25:13 We're heading to a universal toolkit to engineer cells for diverse applications: cancer, autoimmune conditions, neurodegenerative diseases, repair of injured tissue and organs https://t.co/a1h3N2QCQY This week's @ScienceMagazine special section https://t.co/lPuSGVmA5F
2022-11-24 19:04:59 Just published @ScienceMagazine A universal influenza mRNA vaccine effective against all 20 lineages of influenza A and B, effective in experimental models https://t.co/CfABwuE2O0 https://t.co/hyA6lktAgX https://t.co/eyteciqmY2
2022-11-24 02:17:36 There is an impersonator of me, a fake account @EricTopol5, that has been reported @twitter @TwitterSupport
2022-11-24 00:21:29 The stigma and discrimination faced by most people with #LongCovid https://t.co/s4EYkgCv10 @PLOSONE by @PantelichMarija @Dr2NisreenAlwan and colleagues https://t.co/F8MdNUYAGd
2022-11-24 00:11:41 "Our results suggest that the development of a mucosal booster vaccine dose should be further exploited to induce a stronger sIgA response." @NEJM https://t.co/OPEaVtZmQT More rationale a nasal vaccine booster and benefit of mucosal immunity to augment salivary IgA https://t.co/JTX8sDrLyV
2022-11-23 23:35:06 This is about the short term outlook only, as I reviewed here https://t.co/DqMJ7LAALu still needed
2022-11-23 22:43:13 A very informative, fun and engaging conversation with @trishgreenhalgh about what constitutes evidence in medicine and the pandemic https://t.co/IaVXavjlC7 W/ @cuttingforstone @Medscape
2022-11-23 17:53:31 On the 1-year anniversary of Omicron’s detection, things are looking up. Worse variants countered by tens of millions of infections, vaccines, and boosters make a difference https://t.co/AsFyGcpFK9
2022-11-23 16:33:10 Japan's 2nd BA.5 wave reaches case peak level of Omicron BA.1 (>
2022-11-23 16:02:02 Good Intro editing :-) by @stephanpastis https://t.co/do6Lg8W93j
2022-11-22 23:11:25 In synch with the hopeful tone https://t.co/uliFt9RZTS https://t.co/tHHLSvHdfg
2022-11-22 20:53:31 Vaccine effectiveness vs reinfection, a Denmark nationwide study The reduction of reinfection after primary vaccination was significant for the Alpha, Delta, and Omicron variant periods, ranging from 60-94%, lasting up to 9 months https://t.co/C9gWMfC1Tc @PLOSMedicine https://t.co/5VZq1Hgwk2
2022-11-22 20:46:42 Illuminating new @CDCMMWR repot for real world Paxlovid reduction of hospitalization by ~50% across all subgroups by age, vaccinated status, prior infection, month of infection (proxy for variant) https://t.co/LoMLSPepmd https://t.co/oLNscrf5M4
2022-11-22 20:05:09 New @CDCgov data for reduction of deaths by vaccination/boosters for age 12+ through September 2022 https://t.co/HGyjNwCm0v https://t.co/zo345UNZgb
2022-11-22 16:19:46 “Americans have been trained for 100 years to think that the hospital is the best place to be, the safest place. But we have strong evidence that the outcomes are actually better at home.” The hospital-at-home movement is just getting started https://t.co/TnfDzSCeoK @paula_span https://t.co/tvxqFMqwE5
2022-11-22 16:07:48 Our digital times :-) by @speedbumpcomic https://t.co/owtpzW5NqN
2022-11-21 16:14:51 As of 10 November 2022, it is estimated that 94% of Americans have had Covid at least once, much of those infections in the past year. Ranking of states w/ most vulnerability d/t lack of vaccines/ boosters https://t.co/W5zzyrD0vN @HarvardChanSPH https://t.co/FlY9MqC3Jq
2022-11-21 14:55:09 Unlike the prior 2 holiday seasons in the US, a major surge is unlikely, which is not in keeping with new, dominant variants with marked immune evasion. https://t.co/DqMJ7LAALu However, waning of immunity, poor uptake of boosters, and lack of mitigation sets up vulnerability https://t.co/rEQSBzeewg
2022-11-21 14:38:35 Encouraging new data for @Novavax boosters (1st and 2nd) for inducing neutralizing antibody response vs BA.5 https://t.co/CmpPueCwuG https://t.co/sbeWpljL7e
2022-11-21 14:28:55 Myocarditis after mRNA Covid vaccines: results from over 10 million doses in British Columbia https://t.co/CrnzxyPSDX @CMAJ https://t.co/y4rcdcJS67
2022-11-21 03:25:03 @kjhyuijhybh Yes I did that https://t.co/mJyBxYKymV
2022-11-21 03:24:06 @fstults2 https://t.co/mJyBxZ1BoV works
2022-11-21 01:21:26 Tumors also can have fungi within them which can, like (and interact with) bacteria, have functional impact on cancer and its therapy https://t.co/KDWV9XjQzW @CellCellPress https://t.co/72eyqbrMq0
2022-11-21 00:03:11 @steveagee Approved in China, India, Iran Big clinical trial in Mexico A company (Ocugen) has licensed the Bharat Biotech (India, IP from @WUSTL) for the United States but there’s no regulatory guidance by @US_FDA yet for Covid nasal vaccines
2022-11-20 23:46:08 RT @EricTopol: My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SAR…
2022-11-20 23:14:08 @kellyclose Both, Kelly. T1D mostly in young, predominantly T2D overall
2022-11-20 22:12:36 Great to see a big win for @UVA @UVAMensHoops
2022-11-20 19:10:31 https://t.co/N60zU6pExk
2022-11-20 19:10:30 Bacteria within tumors are capable of suppressing the immune response and promoting cancer spread https://t.co/g0WfQOd6lA @nature elegant work by @BullmanLab and @CJohnstonLab1 using spatial genomics https://t.co/K1sAMmpvhS https://t.co/C62S0nwLFR
2022-11-20 18:55:24 The consistent increased risk of diabetes after Covid across all age groups, highest in the first 3 months after infection, from a systematic review of 9 studies, ~40 million people https://t.co/uJ5T3ENGrj https://t.co/GZzZmhDrfH
2022-11-20 18:41:40 No need to dream anymore. This can be done. But it takes will, priority and funding And debunking the delusion that we're done with #SARSCoV2 https://t.co/TrR777xZTI https://t.co/eKHGg7EPtM https://t.co/1ijx5gN79W
2022-11-20 17:54:58 Months ago @VirusesImmunity and I laid out the strong case for nasal vaccines to achieve containment of the virus, breaking the chain of transmission at the individual and population level https://t.co/OujfFxMgU6 @SciImmunology https://t.co/lPGQTC2T1i
2022-11-20 16:23:27 I'm outraged by this pathetic and inexcusable inability for this country to go after nasal and better, durable, variant-proof vaccines https://t.co/u2AErUyYpN https://t.co/CuRQ51q8pi
2022-11-20 16:10:23 The variants accounting for new cases in Japan as of 11 November https://t.co/Tkkh0fwsf9 https://t.co/2JPHxUOxG1
2022-11-20 15:58:24 There's a 2nd BA.5 wave happening in Japan, the country that has best managed the pandemic https://t.co/z68bDAyl3a https://t.co/FTGx5BB1qt
2022-11-20 15:45:21 Why is the outlook favorable when new variants with marked immune evasion and growth advantage have become dominant? https://t.co/DqMJ7LSJZC
2022-11-19 20:21:41 A new and useful perspective on this report @NatRevNeurol https://t.co/wZ9kvh567Q by @alessandro5161 and @andreapilotto https://t.co/cjturtGVq2
2022-11-19 20:00:42 @TheLarvinMewis Thank you!
2022-11-19 19:46:26 My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SARSCoV2 variant with a marked increase in immune evasion not to have induced a wave. https://t.co/DqMJ7LAALu
2022-11-19 15:35:10 Correcting my typo: it's ronna, not rona More on this here @nature by @LizzieGibney https://t.co/Erb4zTYWCl https://t.co/zMGRoGHeTk
2022-11-19 15:20:02 I thought that many bytes should be named helluva but the new name is quetta https://t.co/d77lA6LTc2
2022-11-19 00:57:34 This poses a major concern for immunocompromised who have benefited from Evusheld (preventive) &
2022-11-19 00:57:33 The BQ.1.1 variant, as compared with many of the other new variants, is resistant to all clinically used monoclonal antibodies. BQ.1/BQ.1.1 are now the dominant variants in the United States https://t.co/PCFPSGF2uy @TheLancetInfDis https://t.co/dHucxoGokC
2022-11-18 21:17:45 Good news: 1st drug to alter the course of Type 1 diabetes in 100 years approved by @US_FDA Bad news: it costs ~$200,000/14-day treatment
2022-11-18 20:40:04 @legalnomads BA.1 bivalent induces about half as much neutralizing antibodies vs BA.5 as the BA.5 bivalent (live virus assays), both better than original booster. Whether that translates to any difference clinically is unclear.
2022-11-18 20:12:01 The bivalent BA.1 booster is being use in many countries around the world, but data are limited compared with the original (WT) booster against BA.5. New today: doubling of neutralizing antibodies https://t.co/M2YUB5wpH4 (BA.5 bivalent was ~3-5X WT in several recent studies) https://t.co/xYwnfcXkm6
2022-11-18 18:44:04 How to improve science discovery and productivity? Not just about money (see graph below): funding fast, bets on talent/people, take risk, think big https://t.co/HEAXu2L87H by @greg_ip w/ @patrickc @tylercowen @pdhsu https://t.co/7O6qplOf9C
2022-11-18 18:01:46 @KMunoz46 Correct. That's why there's no good explanation
2022-11-18 17:44:15 RT @ElinSilveous: “Foreign rivals have raced ahead in approving long-awaited nasal-spray vaccines, including one invented in St. Louis, cre…
2022-11-18 17:27:39 Does going to @NFL games increase risk of Covid? https://t.co/UzghLiDCgT Interesting findings of an association in the 14-21 day postgame period when >
2022-11-18 16:57:29 If you'd like to boost your protection vs BQ.1.1, 2 new studies that back up the bivalent as the way to get that done https://t.co/wAoTyur6be https://t.co/fDF4KEyJAL https://t.co/FiBnQRxlMG
2022-11-18 16:52:03 US Covid genomics
2022-11-18 15:54:32 A systematic review of Covid vaccines for kids age 5 to 11 (30 studies) Effectiveness 75% vs hospitalization
2022-11-18 15:45:27 @TopherSpiro46 @AshishKJha46 I know, Topher. Absolutely no reason for refusal of Congress and failure to fund. Appreciate @ashishkjha's strong advocacy
2022-11-18 14:58:07 An explainer for why the US is not pursuing nasal vaccines. TLDR: there is no good explanation https://t.co/Ih6ypzOva7 by @benjmueller w/ @VirusesImmunity @florian_krammer
2022-11-18 05:38:35 @hola_jonathan Many thanks!
2022-11-18 05:37:46 @amuendelheim Thanks!
2022-11-18 05:10:48 I'll be here until the lights go out........ You can also find me @erictopol@mstdn.social and https://t.co/YllXWa0b4k https://t.co/5rfMlDkCdM
2022-11-18 03:51:13 @lainemartin1 Very appreciative of your note!
2022-11-18 03:33:22 Refers to BQ.1.1 (see blue arrow)
2022-11-18 03:32:12 New data for why a bivalent booster will help: "These data suggest the bivalent BA.4/5 vaccine is more immunogenic than the original ...vaccine against circulating Omicron sublineages, including BQ.1.1 that is becoming prevalent globally." https://t.co/wAoTyur6be Get boosted! https://t.co/j21g0bELIp
2022-11-18 00:42:08 By current variant growth advantage patterns, the next couple of months in the US will be BQ.1.x dominated. Bivalent boosters will help protect
2022-11-18 00:20:49 @WHCOS Nicely put, Ron. Thanks!
2022-11-18 00:20:19 RT @WHCOS: In simpler terms: Go get your new COVID vaccination now.
2022-11-18 00:06:48 What science forgot during the pandemic https://t.co/12ffbs3ZOF by @richardhorton1 @TheLancet https://t.co/aoJSA3dEco
2022-11-17 23:56:45 A new report confirms the immune escape of the BQ.1.1 variant, along with BA.4.6 &
2022-11-17 23:26:54 We still don't have a way to diagnosis chronic traumatic encephalopathy (CTE) in people who are alive, but may be getting closer https://t.co/SftRQR7TWD by @el_belson @NYTSports https://t.co/BTh6oXUxRg
2022-11-17 21:47:06 RT @rowlsmanthorpe: Long covid has wrecked my life It’s bad, very bad. But you knew that already I want to tell you a hopeful story. A st…
2022-11-17 19:37:27 @PraliNoisette I don't see any sign of that https://t.co/e7u7aZCfBZ
2022-11-17 19:12:51 To note https://t.co/y2qdjFrvDR
2022-11-17 19:11:30 75 years later we have chips with >
2022-11-17 18:08:47 BA.5, déjà vu https://t.co/eILO8PxIkY
2022-11-17 17:33:41 RT @linseymarr: You get a 2-for-1 with filtration. It removes virus from the air and PM2.5 that is associated with an increased risk of inf…
2022-11-17 17:28:45 RT @Aiims1742: Important #OpenAccess paper in @Cancer_Cell from @CharlesSwanton &
2022-11-17 17:09:54 Strong evidence that particulate matter air pollution (ambient PM2.5) increases the risk of Covid infection, a systematic analysis https://t.co/RueG44Hk2m @MonashUni https://t.co/kpREoqJVPi
2022-11-17 15:46:50 About 1 in 5 of us have an APOE4 gene variant, the #1 genetic risk factor for Alzheimer's disease. But the mechanism for brain injury was a mystery, now getting unraveled (cholesterol processing by oligodendrocytes) https://t.co/gIpGt0CA28 @nature https://t.co/hbmdpO6R3t https://t.co/4zFZIhUTCI
2022-11-17 01:27:50 @amitsurg Because they do. That's mostly related to the excess of rebound after Paxlovid
2022-11-17 00:58:05 We've (re-)learned a few important lessons from the Paxlovid rebound experience about randomized trials and real world evidence Reviewed here https://t.co/jmT9vIipg9
2022-11-16 19:46:41 The Paxlovid rebound story New data reviewed in the 16 November daily briefing of Ground Truths https://t.co/jmT9vIipg9
2022-11-16 17:48:15 The US Covid death rate (7-day average) drops below 300 for the first time since June 2022. Lowest since pandemic began was 222 in July 2021. https://t.co/Cze8bZgtVr https://t.co/uxGosRY1KO
2022-11-16 17:14:12 Immunotherapy can induce myocarditis but the mechanism has been poorly understood. A new report @nature today supports the culprit auto-antigen role of α-myosin and cytotoxic T-cells directed to it https://t.co/uPRUQBbkVh by @MargaretAxelrod @BalkoLab https://t.co/vWZP1IcW19
2022-11-16 16:37:07 Humidity (indoor, relative) is associated with outcomes of Covid infections, a population-based study in 121 countries https://t.co/dWMmyMfBSL https://t.co/hW7Jq1mhdo
2022-11-16 01:17:21 RT @PeterHotez: Important and well-conducted study by @EricTopol My take: even though rebound is real and significant, in my conversation…
2022-11-15 23:33:25 For the people pointing out that @POTUS, @CDCDirector and Tony Fauci all had Paxlovid rebound, that's why you do prospective, systematic studies. We've learned that "rebound" also occurs without Paxlovid and that anecdotes/twitter are not representative of the real world
2022-11-15 20:14:34 Each participant did rapid antigen testing every other day through day 15, symptom surveys through day 17, and are being followed for 6 months https://t.co/8bDtswdytR
2022-11-15 20:00:32 The event curves for Paxlovid treated compared with controls https://t.co/2ykeOuBUAX
2022-11-15 19:56:25 Our prospective Paxlovid rebound study with controls preprint is posted By symptoms: ~12% rebound (19% Pax vs 7% controls) By positive testing: ~5% rebound (14% Pax vs 9% controls) Much lower than many estimates https://t.co/czeGEYIJvA by @JayPandit @michaelmina_lab @ScrippsRTI
2022-11-15 19:45:43 Foundation #AI models come to science https://t.co/G7Xx31w1Of https://t.co/HNjVOs3J4I
2022-11-15 19:23:17 @Jdrodric12 that's right!
2022-11-15 18:47:56 @SarahWLaurence @ScrippsRTI Thank you!
2022-11-15 18:31:49 On a day when the world has reached about ~8 billion people, it's notable there have been >
2022-11-15 17:10:19 @surrogateexpare @Medscape Included here https://t.co/bugfFk44sh@Medscape Please fix the links
2022-11-15 17:09:38 This post has all the relevant links and review the recent its for protection vs #LongCovid https://t.co/bugfFk44sh
2022-11-15 16:30:20 Paxlovid interactionsA new report claims 14.6% of patients had contraindications to treatment. But most of these meds could have been safely stopped for 5 dayshttps://t.co/FP3o0J0eBzMore on this herehttps://t.co/i3pUyAJlAs @Medscape https://t.co/0tsAf3xUqu
2022-11-15 16:11:35 Start of new waves in South Korea and Japan, having sustained recent BA.5 waves and this variant still accounts for most new casesThe pandemic isn't over https://t.co/DhwWhZ4CJi
2022-11-15 16:01:28 Here's the article. A potential path to preventing brain tissue from dying https://t.co/ODGuD8X8iy
2022-11-15 00:48:03 Today's pandemic briefing on new booster data and the thick soup of new variantshttps://t.co/LA3nl6FxSx
2022-11-14 17:22:13 RT @danrdanny: Excited to see our work on 3-hour genome sequencing highlighted here! If you think this is interesting we have a bench scien…
2022-11-14 17:04:44 The potential for detecting heart dysfunction (ejection fraction <
2022-11-14 14:37:14 RT @EricTopol: Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so m…
2022-11-14 14:28:16 In aggregate, solid evidence that the bivalent booster elicits a strong and broadened neutralizing antibody immune response. Yet, less than 27% of Americans 65+, the have had it and poor uptake across all age groupshttps://t.co/V5Xlj3cKln
2022-11-14 14:28:15 https://t.co/fJbLUdcYJdCoverage @statnews by @matthewherper w/ @SutharLab, whose results were replicated by the new data (Table)
2022-11-14 12:00:01 Moderna BA.5 bivalent booster results announced (via @moderna_tx press release)—largest study to date of >
2022-11-29 01:23:20 RT @CorneliusRoemer: I'm seeing quite a bit of discussion about the potential impact of a big wave in mainland China on variant evolution.…
2022-11-29 00:43:08 Good thing it's so simple to predict optimal vaccine response
2022-11-28 22:36:33 In the 2nd year of the US pandemic "the shift in COVID-19 mortality to relatively younger people.. .contributed to markedly elevated years of life lost (YLL) from this increasingly preventable cause of death" https://t.co/Vj0DleONDZ @AnnalsofIM @MarkCzeisler https://t.co/nX7ZrnF9tG
2022-11-28 22:12:32 A randomized trial of medical masks vs N95s in health care workers to prevent Covid https://t.co/CSJkFLE15z —It's woefully underpowered but ruled out a doubling of hazard for use of medical masks —In 3 of the 4 countries there was less risk with N95s (p=NS) https://t.co/B7iBvT1J9B
2022-11-28 21:20:35 Despite David Ho and colleagues new preprint, I wrote that the concerns over these variants have yet to be clinically manifest. It's the 1st time in the pandemic that lab assays of marked increases in immune evasion have not played out w/ new major surges https://t.co/DqMJ7LSJZC
2022-11-28 20:51:49 "The extent of the antigenic drift or shift measured herein is comparable to the antigenic leap made by the initial Omicron variant from its predecessors one year ago." https://t.co/2wDWjZkTr7
2022-11-28 20:51:47 Nonetheless "Our findings indicate that BQ &
2022-11-28 20:42:33 A note of alarm from Ho lab about the immune escape features of XBB &
2022-11-28 19:52:20 Disruption of the gut microbiome by Covid infections https://t.co/eZO3FBW5xS by Martin Blaser and colleagues @RutgersCABM https://t.co/bFUwDEjFFJ
2022-11-28 19:25:44 Very concerning about the new drug w/modest effects for Alzheimer's disease (AD) "If the patient hadn’t been on lecanemab she would be alive today.” Underlying cerebral amyloid angiopathy is present in nearly half of AD patients https://t.co/UNRoKcICNw @cpiller @ScienceMagazine
2022-11-28 16:51:27 The pandemic isn't over. Besides the major trouble that is brewing in China, it's notable that Japan's new wave has exceeded its Omicron BA.1 surge, averaging over 100,000 cases/day, and still is on steep ascent @OurWorldInData https://t.co/XnNveiLs33
2022-11-28 16:43:14 It doesn't help that the @CDCgov still defines "fully vaccinated" as 2 shots, when it would now have taken 5 shots to counter the waning immunity/protect vs severe Covid for people age 50+
2022-11-28 15:34:09 Mask psychology by @lianafinck @NewYorker https://t.co/2uGXaeJhFe
2022-11-28 15:00:27 In the last month, nearly 90% of the deaths from Covid were in people age 65+ (16% of the US population). Their bivalent booster rate is less than 25%. Paxlovid use is low in seniors. A high % of these deaths are preventable. https://t.co/X3DTJcrU4F @arianaeunjung @dtkeating https://t.co/PBWUvsn3W4
2022-11-28 14:49:23 Help Elon :-) by @stephanpastis https://t.co/UMFrafyakl
2022-11-27 22:12:09 These projections for China were based on modeling. But with the low rate of seniors with booster shots, lower efficacy of their vaccines vs Omicron subvariants, and now inability to contain the virus, major trouble lies ahead https://t.co/2Ddz6coeNU
2022-11-27 03:40:59 If we can do a universal influenza vaccine, a pan-β-coronavirus (variant-proof) virus is well within reach!
2022-11-26 19:35:11 Not a good look for Covid in Arizona —Most increase in US hospitalizations in the past 2 weeks, notable in age 70+ —Hard to attribute to BQ.1.1 or other new variants https://t.co/Cze8bZxwXr https://t.co/xGxvgnpKiM
2022-11-26 17:01:55 The BQ.1.1 variant is resistant to all available monoclonal antibodies, including Evusheld and Bebtelovimab, leaving immunocompromised individuals particularly vulnerable. There are a few new antibodies currently being tested, with some promise https://t.co/Atfwxm2hjV @majohnso https://t.co/sjthau0XGT
2022-11-26 02:42:30 RT @DrTomasAragon: Here is are two papers from @trishgreenhalgh that complements this great podcast with @EricTopol - https://t.co/q9bk5jV…
2022-11-26 02:41:55 @dokhollidays Thank you!
2022-11-26 01:44:24 Evolution of the Omicron family of variants https://t.co/UnFls9aXeq by @CorneliusRoemer @LongDesertTrain @PeacockFlu and colleagues "It is entirely possible all the lineages described here would be outcompeted in the event of a second ‘Omicron-like event’" https://t.co/W0C7lTKx40
2022-11-25 21:18:05 RT @DrSethPT: “Whilst RCTs are a fantastic idea for testing drugs, they are a catastrophically bad idea for testing loads of other things.”…
2022-11-25 20:54:07 Genome editing to restore heart function of dilated cardiomyopathy in experimental model https://t.co/QsU87cYuAu @ScienceTM https://t.co/0msjDZmn1I
2022-11-25 17:29:51 Hope for avoiding a holiday Covid surge https://t.co/GpMStLVkrt by @jon_kamp In depth: https://t.co/DqMJ7LAALu https://t.co/gNqutFc8wm
2022-11-25 17:22:37 Common threads between #SARSCoV2 brain involvement and Alzheimer's disease at post-mortem: pattern of neuroinflammation and gene expression, microglia nodule formation, pathway activation, and vascular injury https://t.co/ln41iwTlvG @Pasing01 @IcahnMountSinai @IcahnCMIN https://t.co/UeUh2dOuRV
2022-11-25 16:51:06 Growth curves of BQ.1.1 and XBB in Region 2 (includes New York). The BQ.1s are >
2022-11-25 16:24:49 This week's CDC genomic update shows that 57% of new cases are due to BQ.1/BQ.1.1 variants as BA.5 fades and small increases in a few other variants (XBB, BN.1, BA.2.75) https://t.co/jjl2AnwOWX https://t.co/IWoEZFI5Rb
2022-11-25 15:57:51 Our digital times :-) @speedbumpcomic https://t.co/62Tuq2ozPl
2022-11-25 15:37:26 The molecular mechanism of #SARSCoV2 infection https://t.co/zxLN8q66Rf @ScienceMagazine highlighting the role of endosomes in a prize winning essay https://t.co/l3yukGRZ9B
2022-11-24 19:58:48 The growing body of evidence that the 3 respiratory viruses (Covid, flu, RSV) interfere with each other’s spread, limiting a tripledemic's threat https://t.co/auPadYfbsa @ScienceMagazine by @sciencecohen https://t.co/yUKqrZyNUW
2022-11-24 19:25:13 We're heading to a universal toolkit to engineer cells for diverse applications: cancer, autoimmune conditions, neurodegenerative diseases, repair of injured tissue and organs https://t.co/a1h3N2QCQY This week's @ScienceMagazine special section https://t.co/lPuSGVmA5F
2022-11-24 19:04:59 Just published @ScienceMagazine A universal influenza mRNA vaccine effective against all 20 lineages of influenza A and B, effective in experimental models https://t.co/CfABwuE2O0 https://t.co/hyA6lktAgX https://t.co/eyteciqmY2
2022-11-24 02:17:36 There is an impersonator of me, a fake account @EricTopol5, that has been reported @twitter @TwitterSupport
2022-11-24 00:21:29 The stigma and discrimination faced by most people with #LongCovid https://t.co/s4EYkgCv10 @PLOSONE by @PantelichMarija @Dr2NisreenAlwan and colleagues https://t.co/F8MdNUYAGd
2022-11-24 00:11:41 "Our results suggest that the development of a mucosal booster vaccine dose should be further exploited to induce a stronger sIgA response." @NEJM https://t.co/OPEaVtZmQT More rationale a nasal vaccine booster and benefit of mucosal immunity to augment salivary IgA https://t.co/JTX8sDrLyV
2022-11-23 23:35:06 This is about the short term outlook only, as I reviewed here https://t.co/DqMJ7LAALu still needed
2022-11-23 22:43:13 A very informative, fun and engaging conversation with @trishgreenhalgh about what constitutes evidence in medicine and the pandemic https://t.co/IaVXavjlC7 W/ @cuttingforstone @Medscape
2022-11-23 17:53:31 On the 1-year anniversary of Omicron’s detection, things are looking up. Worse variants countered by tens of millions of infections, vaccines, and boosters make a difference https://t.co/AsFyGcpFK9
2022-11-23 16:33:10 Japan's 2nd BA.5 wave reaches case peak level of Omicron BA.1 (>
2022-11-23 16:02:02 Good Intro editing :-) by @stephanpastis https://t.co/do6Lg8W93j
2022-11-22 23:11:25 In synch with the hopeful tone https://t.co/uliFt9RZTS https://t.co/tHHLSvHdfg
2022-11-22 20:53:31 Vaccine effectiveness vs reinfection, a Denmark nationwide study The reduction of reinfection after primary vaccination was significant for the Alpha, Delta, and Omicron variant periods, ranging from 60-94%, lasting up to 9 months https://t.co/C9gWMfC1Tc @PLOSMedicine https://t.co/5VZq1Hgwk2
2022-11-22 20:46:42 Illuminating new @CDCMMWR repot for real world Paxlovid reduction of hospitalization by ~50% across all subgroups by age, vaccinated status, prior infection, month of infection (proxy for variant) https://t.co/LoMLSPepmd https://t.co/oLNscrf5M4
2022-11-22 20:05:09 New @CDCgov data for reduction of deaths by vaccination/boosters for age 12+ through September 2022 https://t.co/HGyjNwCm0v https://t.co/zo345UNZgb
2022-11-22 16:19:46 “Americans have been trained for 100 years to think that the hospital is the best place to be, the safest place. But we have strong evidence that the outcomes are actually better at home.” The hospital-at-home movement is just getting started https://t.co/TnfDzSCeoK @paula_span https://t.co/tvxqFMqwE5
2022-11-22 16:07:48 Our digital times :-) by @speedbumpcomic https://t.co/owtpzW5NqN
2022-11-21 16:14:51 As of 10 November 2022, it is estimated that 94% of Americans have had Covid at least once, much of those infections in the past year. Ranking of states w/ most vulnerability d/t lack of vaccines/ boosters https://t.co/W5zzyrD0vN @HarvardChanSPH https://t.co/FlY9MqC3Jq
2022-11-21 14:55:09 Unlike the prior 2 holiday seasons in the US, a major surge is unlikely, which is not in keeping with new, dominant variants with marked immune evasion. https://t.co/DqMJ7LAALu However, waning of immunity, poor uptake of boosters, and lack of mitigation sets up vulnerability https://t.co/rEQSBzeewg
2022-11-21 14:38:35 Encouraging new data for @Novavax boosters (1st and 2nd) for inducing neutralizing antibody response vs BA.5 https://t.co/CmpPueCwuG https://t.co/sbeWpljL7e
2022-11-21 14:28:55 Myocarditis after mRNA Covid vaccines: results from over 10 million doses in British Columbia https://t.co/CrnzxyPSDX @CMAJ https://t.co/y4rcdcJS67
2022-11-21 03:25:03 @kjhyuijhybh Yes I did that https://t.co/mJyBxYKymV
2022-11-21 03:24:06 @fstults2 https://t.co/mJyBxZ1BoV works
2022-11-21 01:21:26 Tumors also can have fungi within them which can, like (and interact with) bacteria, have functional impact on cancer and its therapy https://t.co/KDWV9XjQzW @CellCellPress https://t.co/72eyqbrMq0
2022-11-21 00:03:11 @steveagee Approved in China, India, Iran Big clinical trial in Mexico A company (Ocugen) has licensed the Bharat Biotech (India, IP from @WUSTL) for the United States but there’s no regulatory guidance by @US_FDA yet for Covid nasal vaccines
2022-11-20 23:46:08 RT @EricTopol: My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SAR…
2022-11-20 23:14:08 @kellyclose Both, Kelly. T1D mostly in young, predominantly T2D overall
2022-11-20 22:12:36 Great to see a big win for @UVA @UVAMensHoops
2022-11-20 19:10:31 https://t.co/N60zU6pExk
2022-11-20 19:10:30 Bacteria within tumors are capable of suppressing the immune response and promoting cancer spread https://t.co/g0WfQOd6lA @nature elegant work by @BullmanLab and @CJohnstonLab1 using spatial genomics https://t.co/K1sAMmpvhS https://t.co/C62S0nwLFR
2022-11-20 18:55:24 The consistent increased risk of diabetes after Covid across all age groups, highest in the first 3 months after infection, from a systematic review of 9 studies, ~40 million people https://t.co/uJ5T3ENGrj https://t.co/GZzZmhDrfH
2022-11-20 18:41:40 No need to dream anymore. This can be done. But it takes will, priority and funding And debunking the delusion that we're done with #SARSCoV2 https://t.co/TrR777xZTI https://t.co/eKHGg7EPtM https://t.co/1ijx5gN79W
2022-11-20 17:54:58 Months ago @VirusesImmunity and I laid out the strong case for nasal vaccines to achieve containment of the virus, breaking the chain of transmission at the individual and population level https://t.co/OujfFxMgU6 @SciImmunology https://t.co/lPGQTC2T1i
2022-11-20 16:23:27 I'm outraged by this pathetic and inexcusable inability for this country to go after nasal and better, durable, variant-proof vaccines https://t.co/u2AErUyYpN https://t.co/CuRQ51q8pi
2022-11-20 16:10:23 The variants accounting for new cases in Japan as of 11 November https://t.co/Tkkh0fwsf9 https://t.co/2JPHxUOxG1
2022-11-20 15:58:24 There's a 2nd BA.5 wave happening in Japan, the country that has best managed the pandemic https://t.co/z68bDAyl3a https://t.co/FTGx5BB1qt
2022-11-20 15:45:21 Why is the outlook favorable when new variants with marked immune evasion and growth advantage have become dominant? https://t.co/DqMJ7LSJZC
2022-11-19 20:21:41 A new and useful perspective on this report @NatRevNeurol https://t.co/wZ9kvh567Q by @alessandro5161 and @andreapilotto https://t.co/cjturtGVq2
2022-11-19 20:00:42 @TheLarvinMewis Thank you!
2022-11-19 19:46:26 My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe. The first #SARSCoV2 variant with a marked increase in immune evasion not to have induced a wave. https://t.co/DqMJ7LAALu
2022-11-19 15:35:10 Correcting my typo: it's ronna, not rona More on this here @nature by @LizzieGibney https://t.co/Erb4zTYWCl https://t.co/zMGRoGHeTk
2022-11-19 15:20:02 I thought that many bytes should be named helluva but the new name is quetta https://t.co/d77lA6LTc2
2022-11-19 00:57:34 This poses a major concern for immunocompromised who have benefited from Evusheld (preventive) &
2022-11-19 00:57:33 The BQ.1.1 variant, as compared with many of the other new variants, is resistant to all clinically used monoclonal antibodies. BQ.1/BQ.1.1 are now the dominant variants in the United States https://t.co/PCFPSGF2uy @TheLancetInfDis https://t.co/dHucxoGokC
2022-11-18 21:17:45 Good news: 1st drug to alter the course of Type 1 diabetes in 100 years approved by @US_FDA Bad news: it costs ~$200,000/14-day treatment
2022-11-18 20:40:04 @legalnomads BA.1 bivalent induces about half as much neutralizing antibodies vs BA.5 as the BA.5 bivalent (live virus assays), both better than original booster. Whether that translates to any difference clinically is unclear.
2022-11-18 20:12:01 The bivalent BA.1 booster is being use in many countries around the world, but data are limited compared with the original (WT) booster against BA.5. New today: doubling of neutralizing antibodies https://t.co/M2YUB5wpH4 (BA.5 bivalent was ~3-5X WT in several recent studies) https://t.co/xYwnfcXkm6
2022-11-18 18:44:04 How to improve science discovery and productivity? Not just about money (see graph below): funding fast, bets on talent/people, take risk, think big https://t.co/HEAXu2L87H by @greg_ip w/ @patrickc @tylercowen @pdhsu https://t.co/7O6qplOf9C
2022-11-18 18:01:46 @KMunoz46 Correct. That's why there's no good explanation
2022-11-18 17:44:15 RT @ElinSilveous: “Foreign rivals have raced ahead in approving long-awaited nasal-spray vaccines, including one invented in St. Louis, cre…
2022-11-18 17:27:39 Does going to @NFL games increase risk of Covid? https://t.co/UzghLiDCgT Interesting findings of an association in the 14-21 day postgame period when >
2022-11-18 16:57:29 If you'd like to boost your protection vs BQ.1.1, 2 new studies that back up the bivalent as the way to get that done https://t.co/wAoTyur6be https://t.co/fDF4KEyJAL https://t.co/FiBnQRxlMG
2022-11-18 16:52:03 US Covid genomics
2022-11-18 15:54:32 A systematic review of Covid vaccines for kids age 5 to 11 (30 studies) Effectiveness 75% vs hospitalization
2022-11-18 15:45:27 @TopherSpiro46 @AshishKJha46 I know, Topher. Absolutely no reason for refusal of Congress and failure to fund. Appreciate @ashishkjha's strong advocacy
2022-11-18 14:58:07 An explainer for why the US is not pursuing nasal vaccines. TLDR: there is no good explanation https://t.co/Ih6ypzOva7 by @benjmueller w/ @VirusesImmunity @florian_krammer
2022-11-18 05:38:35 @hola_jonathan Many thanks!
2022-11-18 05:37:46 @amuendelheim Thanks!
2022-11-18 05:10:48 I'll be here until the lights go out........ You can also find me @erictopol@mstdn.social and https://t.co/YllXWa0b4k https://t.co/5rfMlDkCdM
2022-11-18 03:51:13 @lainemartin1 Very appreciative of your note!
2022-11-18 03:33:22 Refers to BQ.1.1 (see blue arrow)
2022-11-18 03:32:12 New data for why a bivalent booster will help: "These data suggest the bivalent BA.4/5 vaccine is more immunogenic than the original ...vaccine against circulating Omicron sublineages, including BQ.1.1 that is becoming prevalent globally." https://t.co/wAoTyur6be Get boosted! https://t.co/j21g0bELIp
2022-11-18 00:42:08 By current variant growth advantage patterns, the next couple of months in the US will be BQ.1.x dominated. Bivalent boosters will help protect
2022-11-18 00:20:49 @WHCOS Nicely put, Ron. Thanks!
2022-11-18 00:20:19 RT @WHCOS: In simpler terms: Go get your new COVID vaccination now.
2022-11-18 00:06:48 What science forgot during the pandemic https://t.co/12ffbs3ZOF by @richardhorton1 @TheLancet https://t.co/aoJSA3dEco
2022-11-17 23:56:45 A new report confirms the immune escape of the BQ.1.1 variant, along with BA.4.6 &
2022-11-17 23:26:54 We still don't have a way to diagnosis chronic traumatic encephalopathy (CTE) in people who are alive, but may be getting closer https://t.co/SftRQR7TWD by @el_belson @NYTSports https://t.co/BTh6oXUxRg
2022-11-17 21:47:06 RT @rowlsmanthorpe: Long covid has wrecked my life It’s bad, very bad. But you knew that already I want to tell you a hopeful story. A st…
2022-11-17 19:37:27 @PraliNoisette I don't see any sign of that https://t.co/e7u7aZCfBZ
2022-11-17 19:12:51 To note https://t.co/y2qdjFrvDR
2022-11-17 19:11:30 75 years later we have chips with >
2022-11-17 18:08:47 BA.5, déjà vu https://t.co/eILO8PxIkY
2022-11-17 17:33:41 RT @linseymarr: You get a 2-for-1 with filtration. It removes virus from the air and PM2.5 that is associated with an increased risk of inf…
2022-11-17 17:28:45 RT @Aiims1742: Important #OpenAccess paper in @Cancer_Cell from @CharlesSwanton &
2022-11-17 17:09:54 Strong evidence that particulate matter air pollution (ambient PM2.5) increases the risk of Covid infection, a systematic analysis https://t.co/RueG44Hk2m @MonashUni https://t.co/kpREoqJVPi
2022-11-17 15:46:50 About 1 in 5 of us have an APOE4 gene variant, the #1 genetic risk factor for Alzheimer's disease. But the mechanism for brain injury was a mystery, now getting unraveled (cholesterol processing by oligodendrocytes) https://t.co/gIpGt0CA28 @nature https://t.co/hbmdpO6R3t https://t.co/4zFZIhUTCI
2022-11-17 01:27:50 @amitsurg Because they do. That's mostly related to the excess of rebound after Paxlovid
2022-11-17 00:58:05 We've (re-)learned a few important lessons from the Paxlovid rebound experience about randomized trials and real world evidence Reviewed here https://t.co/jmT9vIipg9
2022-11-16 19:46:41 The Paxlovid rebound story New data reviewed in the 16 November daily briefing of Ground Truths https://t.co/jmT9vIipg9
2022-11-16 17:48:15 The US Covid death rate (7-day average) drops below 300 for the first time since June 2022. Lowest since pandemic began was 222 in July 2021. https://t.co/Cze8bZgtVr https://t.co/uxGosRY1KO
2022-11-16 17:14:12 Immunotherapy can induce myocarditis but the mechanism has been poorly understood. A new report @nature today supports the culprit auto-antigen role of α-myosin and cytotoxic T-cells directed to it https://t.co/uPRUQBbkVh by @MargaretAxelrod @BalkoLab https://t.co/vWZP1IcW19
2022-11-16 16:37:07 Humidity (indoor, relative) is associated with outcomes of Covid infections, a population-based study in 121 countries https://t.co/dWMmyMfBSL https://t.co/hW7Jq1mhdo
2022-11-16 01:17:21 RT @PeterHotez: Important and well-conducted study by @EricTopol My take: even though rebound is real and significant, in my conversation…
2022-11-15 23:33:25 For the people pointing out that @POTUS, @CDCDirector and Tony Fauci all had Paxlovid rebound, that's why you do prospective, systematic studies. We've learned that "rebound" also occurs without Paxlovid and that anecdotes/twitter are not representative of the real world
2022-11-15 20:14:34 Each participant did rapid antigen testing every other day through day 15, symptom surveys through day 17, and are being followed for 6 months https://t.co/8bDtswdytR
2022-11-15 20:00:32 The event curves for Paxlovid treated compared with controls https://t.co/2ykeOuBUAX
2022-11-15 19:56:25 Our prospective Paxlovid rebound study with controls preprint is posted By symptoms: ~12% rebound (19% Pax vs 7% controls) By positive testing: ~5% rebound (14% Pax vs 9% controls) Much lower than many estimates https://t.co/czeGEYIJvA by @JayPandit @michaelmina_lab @ScrippsRTI
2022-11-15 19:45:43 Foundation #AI models come to science https://t.co/G7Xx31w1Of https://t.co/HNjVOs3J4I
2022-11-15 19:23:17 @Jdrodric12 that's right!
2022-11-15 18:47:56 @SarahWLaurence @ScrippsRTI Thank you!
2022-11-15 18:31:49 On a day when the world has reached about ~8 billion people, it's notable there have been >
2022-11-15 17:10:19 @surrogateexpare @Medscape Included here https://t.co/bugfFk44sh@Medscape Please fix the links
2022-11-15 17:09:38 This post has all the relevant links and review the recent its for protection vs #LongCovid https://t.co/bugfFk44sh
2022-11-15 16:30:20 Paxlovid interactionsA new report claims 14.6% of patients had contraindications to treatment. But most of these meds could have been safely stopped for 5 dayshttps://t.co/FP3o0J0eBzMore on this herehttps://t.co/i3pUyAJlAs @Medscape https://t.co/0tsAf3xUqu
2022-11-15 16:11:35 Start of new waves in South Korea and Japan, having sustained recent BA.5 waves and this variant still accounts for most new casesThe pandemic isn't over https://t.co/DhwWhZ4CJi
2022-11-15 16:01:28 Here's the article. A potential path to preventing brain tissue from dying https://t.co/ODGuD8X8iy
2022-11-15 00:48:03 Today's pandemic briefing on new booster data and the thick soup of new variantshttps://t.co/LA3nl6FxSx
2022-11-14 17:22:13 RT @danrdanny: Excited to see our work on 3-hour genome sequencing highlighted here! If you think this is interesting we have a bench scien…
2022-11-14 17:04:44 The potential for detecting heart dysfunction (ejection fraction <
2022-11-14 14:37:14 RT @EricTopol: Whole genome sequencing is now being performed in 83 children's hospitals in the US and Canada for sick newborns. While so m…
2022-11-14 14:28:16 In aggregate, solid evidence that the bivalent booster elicits a strong and broadened neutralizing antibody immune response. Yet, less than 27% of Americans 65+, the have had it and poor uptake across all age groupshttps://t.co/V5Xlj3cKln
2022-11-14 14:28:15 https://t.co/fJbLUdcYJdCoverage @statnews by @matthewherper w/ @SutharLab, whose results were replicated by the new data (Table)
2022-11-14 12:00:01 Moderna BA.5 bivalent booster results announced (via @moderna_tx press release)—largest study to date of >
2022-12-07 20:33:05 "But over the last 30 years or so, I have begun to realize that while RCTs are a brilliant idea for testing drugs, they are a catastrophically bad idea for testing certain other things, masks being one of them."—@trishgreenhalgh https://t.co/IaVXavjlC7 w/ transcript
2022-12-07 19:37:31 @JReinerMD Thanks Jonathan!
2022-12-07 18:54:30 The last time Covid hospital admissions in New York State was this high was in early February 2022 https://t.co/vw77IAyHJj https://t.co/Zwy5b2byHT
2022-12-07 18:50:25 RT @EricTopol: The body of evidence we have for efficacy and safety of Covid vaccines is the largest in the history of medical interventions
2022-12-07 17:59:57 The rise in US Covid hospitalizations may surpass the summer BA.5 wave, fueled by waning immunity, lack of mitigation and BQ.1.1 https://t.co/o5ibW11jaX https://t.co/Y3Uf6EKC3i
2022-12-07 16:07:37 @JillianHortonMD Thank you!
2022-12-07 15:50:42 The denialism of a new wave extends to the risk of infections and reinfections. "Anyone who doesn’t take seriously the risk of COVID infection is in denial about the risk of #LongCovid and its potentially disabling effects."
2022-12-07 15:40:23 During COVID-19, the US lost more life expectancy than almost any other country as assessed here, #dataviz https://t.co/DIxN3ZrvsK @NatureHumBehav @FortuneMagazine by @Trans_World https://t.co/HSx8SprqVN
2022-12-07 15:27:34 Los Angeles County is the largest county in the US with a population of nearly 10 million people Now with a new Covid surge https://t.co/EM7Ei3cpGB @LukeMMoney @ronlin Cases have doubled and hospitalizations are up 77% in the last 2 weeks https://t.co/2hpenSZ59k https://t.co/xXBiuekLJi
2022-12-07 15:18:44 Much can be done to limit the new Covid wave....that isn't being done. https://t.co/cXxjLDiX3e @latimes my oped @latimesopinion https://t.co/JHQh2odOyG
2022-12-07 14:15:25 The body of evidence we have for efficacy and safety of Covid vaccines is the largest in the history of medical interventions
2022-12-07 23:26:54 France is the 1st country to have seen the BQ.1.1 variant become dominant (now >
2022-12-07 23:11:37 Characterization of the immune evasion and cell entry for the new variants: BQ.1.1, XBB.1, and BR.2.1 (<
2022-12-07 20:33:05 "But over the last 30 years or so, I have begun to realize that while RCTs are a brilliant idea for testing drugs, they are a catastrophically bad idea for testing certain other things, masks being one of them."—@trishgreenhalgh https://t.co/IaVXavjlC7 w/ transcript
2022-12-07 19:37:31 @JReinerMD Thanks Jonathan!
2022-12-07 18:54:30 The last time Covid hospital admissions in New York State was this high was in early February 2022 https://t.co/vw77IAyHJj https://t.co/Zwy5b2byHT
2022-12-07 18:50:25 RT @EricTopol: The body of evidence we have for efficacy and safety of Covid vaccines is the largest in the history of medical interventions
2022-12-07 17:59:57 The rise in US Covid hospitalizations may surpass the summer BA.5 wave, fueled by waning immunity, lack of mitigation and BQ.1.1 https://t.co/o5ibW11jaX https://t.co/Y3Uf6EKC3i
2022-12-07 16:07:37 @JillianHortonMD Thank you!
2022-12-07 15:50:42 The denialism of a new wave extends to the risk of infections and reinfections. "Anyone who doesn’t take seriously the risk of COVID infection is in denial about the risk of #LongCovid and its potentially disabling effects."
2022-12-07 15:40:23 During COVID-19, the US lost more life expectancy than almost any other country as assessed here, #dataviz https://t.co/DIxN3ZrvsK @NatureHumBehav @FortuneMagazine by @Trans_World https://t.co/HSx8SprqVN
2022-12-07 15:27:34 Los Angeles County is the largest county in the US with a population of nearly 10 million people Now with a new Covid surge https://t.co/EM7Ei3cpGB @LukeMMoney @ronlin Cases have doubled and hospitalizations are up 77% in the last 2 weeks https://t.co/2hpenSZ59k https://t.co/xXBiuekLJi
2022-12-07 15:18:44 Much can be done to limit the new Covid wave....that isn't being done. https://t.co/cXxjLDiX3e @latimes my oped @latimesopinion https://t.co/JHQh2odOyG
2022-12-07 14:15:25 The body of evidence we have for efficacy and safety of Covid vaccines is the largest in the history of medical interventions
2022-12-08 22:03:27 China's elders problem https://t.co/3TcJQYrFul https://t.co/uG4zedUfuK
2022-12-08 21:43:12 Comparison of ChatGPT and AlphaCode https://t.co/QjlEMViyOT
2022-12-08 21:41:13 @richardludlow @NatureMedicine @ma_hamer @M_Stamatakis No cause and effect established or asserted
2022-12-08 19:46:05 RT @hholdenthorp: Enjoyed talking to Tony Fauci about the last few years and what lies ahead. Lots of great stuff in here for science polic…
2022-12-08 19:22:32 No problem, I'll code for you #AlphaCode https://t.co/7m41MgwHUM "This result marks the 1st time an #AI system has performed competitively in programming competitions" @DeepMind @OriolVinyalsML Not so fast. What it can and can't do. https://t.co/lasA1mJK08 by @zicokolter https://t.co/QqRYL14VJh
2022-12-08 18:40:15 Why does having a human cell atlas, with single-cell and spatial definition, have such transformative potential in medicine? https://t.co/l1II0q1was by @jennyErood @AidMaart @teichlab @GraphicAnja Aviv Regev @NatureMedicine https://t.co/0ZSvKnYaMg
2022-12-08 18:29:52 @JeremyKonyndyk Thanks Jeremy!
2022-12-08 17:36:09 1 vs 3 , a 3-fer https://t.co/ik98DuHT76 by @AlexLJanin w/ @dr_kkjetelina https://t.co/jZnusaUtxA @taraparkerpope @FenitN https://t.co/MyRvFSqD2G
2022-12-08 16:51:44 The conclusion is worth reviewing —1 minute bursts, 3 to 4 per day —for non-exercisers, there's hope —these finding only possible via ~25,000 people from @uk_biobank, wearable sensors, and #AI analytics —1st research to measure VILPA effects https://t.co/ECoOUmaaOo
2022-12-08 16:45:19 @paulg @NatureMedicine @ma_hamer @M_Stamatakis Yes, correct. 1 minute bursts made a difference, 3-4 per of these per day associated with the protection
2022-12-08 16:34:59 Vigorous intermittent lifestyle physical activity (VILPA), 3-4 minute bursts per day, associated with ~40% reduction of all-cause mortality, cancer and cardiovascular mortality https://t.co/BoGmigjqWl @NatureMedicine @ma_hamer @M_Stamatakis https://t.co/UPx61oh4Gs
2022-12-08 16:19:41 Subsequent development of #LongCovid detected by gene expression during acute infection. Two different patterns related to antibody production to spike protein https://t.co/ZklAmwyk4L @NatureMedicine @noambeckmann1 @IcahnMountSinai https://t.co/7uklWADq7e
2022-12-08 15:18:00 RT @Yale: PODCAST: @thehowie and @hmkyale are joined by Dr. Eric Topol, a physician and writer to discuss his career turn toward genomics a…
2022-12-07 23:26:54 France is the 1st country to have seen the BQ.1.1 variant become dominant (now >
2022-12-07 23:11:37 Characterization of the immune evasion and cell entry for the new variants: BQ.1.1, XBB.1, and BR.2.1 (<
2022-12-07 20:33:05 "But over the last 30 years or so, I have begun to realize that while RCTs are a brilliant idea for testing drugs, they are a catastrophically bad idea for testing certain other things, masks being one of them."—@trishgreenhalgh https://t.co/IaVXavjlC7 w/ transcript
2022-12-07 19:37:31 @JReinerMD Thanks Jonathan!
2022-12-07 18:54:30 The last time Covid hospital admissions in New York State was this high was in early February 2022 https://t.co/vw77IAyHJj https://t.co/Zwy5b2byHT
2022-12-07 18:50:25 RT @EricTopol: The body of evidence we have for efficacy and safety of Covid vaccines is the largest in the history of medical interventions
2022-12-07 17:59:57 The rise in US Covid hospitalizations may surpass the summer BA.5 wave, fueled by waning immunity, lack of mitigation and BQ.1.1 https://t.co/o5ibW11jaX https://t.co/Y3Uf6EKC3i
2022-12-07 16:07:37 @JillianHortonMD Thank you!
2022-12-07 15:50:42 The denialism of a new wave extends to the risk of infections and reinfections. "Anyone who doesn’t take seriously the risk of COVID infection is in denial about the risk of #LongCovid and its potentially disabling effects."
2022-12-07 15:40:23 During COVID-19, the US lost more life expectancy than almost any other country as assessed here, #dataviz https://t.co/DIxN3ZrvsK @NatureHumBehav @FortuneMagazine by @Trans_World https://t.co/HSx8SprqVN
2022-12-07 15:27:34 Los Angeles County is the largest county in the US with a population of nearly 10 million people Now with a new Covid surge https://t.co/EM7Ei3cpGB @LukeMMoney @ronlin Cases have doubled and hospitalizations are up 77% in the last 2 weeks https://t.co/2hpenSZ59k https://t.co/xXBiuekLJi
2022-12-07 15:18:44 Much can be done to limit the new Covid wave....that isn't being done. https://t.co/cXxjLDiX3e @latimes my oped @latimesopinion https://t.co/JHQh2odOyG
2022-12-07 14:15:25 The body of evidence we have for efficacy and safety of Covid vaccines is the largest in the history of medical interventions
2022-12-08 22:03:27 China's elders problem https://t.co/3TcJQYrFul https://t.co/uG4zedUfuK
2022-12-08 21:43:12 Comparison of ChatGPT and AlphaCode https://t.co/QjlEMViyOT
2022-12-08 21:41:13 @richardludlow @NatureMedicine @ma_hamer @M_Stamatakis No cause and effect established or asserted
2022-12-08 19:46:05 RT @hholdenthorp: Enjoyed talking to Tony Fauci about the last few years and what lies ahead. Lots of great stuff in here for science polic…
2022-12-08 19:22:32 No problem, I'll code for you #AlphaCode https://t.co/7m41MgwHUM "This result marks the 1st time an #AI system has performed competitively in programming competitions" @DeepMind @OriolVinyalsML Not so fast. What it can and can't do. https://t.co/lasA1mJK08 by @zicokolter https://t.co/QqRYL14VJh
2022-12-08 18:40:15 Why does having a human cell atlas, with single-cell and spatial definition, have such transformative potential in medicine? https://t.co/l1II0q1was by @jennyErood @AidMaart @teichlab @GraphicAnja Aviv Regev @NatureMedicine https://t.co/0ZSvKnYaMg
2022-12-08 18:29:52 @JeremyKonyndyk Thanks Jeremy!
2022-12-08 17:36:09 1 vs 3 , a 3-fer https://t.co/ik98DuHT76 by @AlexLJanin w/ @dr_kkjetelina https://t.co/jZnusaUtxA @taraparkerpope @FenitN https://t.co/MyRvFSqD2G
2022-12-08 16:51:44 The conclusion is worth reviewing —1 minute bursts, 3 to 4 per day —for non-exercisers, there's hope —these finding only possible via ~25,000 people from @uk_biobank, wearable sensors, and #AI analytics —1st research to measure VILPA effects https://t.co/ECoOUmaaOo
2022-12-08 16:45:19 @paulg @NatureMedicine @ma_hamer @M_Stamatakis Yes, correct. 1 minute bursts made a difference, 3-4 per of these per day associated with the protection
2022-12-08 16:34:59 Vigorous intermittent lifestyle physical activity (VILPA), 3-4 minute bursts per day, associated with ~40% reduction of all-cause mortality, cancer and cardiovascular mortality https://t.co/BoGmigjqWl @NatureMedicine @ma_hamer @M_Stamatakis https://t.co/UPx61oh4Gs
2022-12-08 16:19:41 Subsequent development of #LongCovid detected by gene expression during acute infection. Two different patterns related to antibody production to spike protein https://t.co/ZklAmwyk4L @NatureMedicine @noambeckmann1 @IcahnMountSinai https://t.co/7uklWADq7e
2022-12-08 15:18:00 RT @Yale: PODCAST: @thehowie and @hmkyale are joined by Dr. Eric Topol, a physician and writer to discuss his career turn toward genomics a…
2022-12-07 23:26:54 France is the 1st country to have seen the BQ.1.1 variant become dominant (now >
2022-12-07 23:11:37 Characterization of the immune evasion and cell entry for the new variants: BQ.1.1, XBB.1, and BR.2.1 (<
2022-12-07 20:33:05 "But over the last 30 years or so, I have begun to realize that while RCTs are a brilliant idea for testing drugs, they are a catastrophically bad idea for testing certain other things, masks being one of them."—@trishgreenhalgh https://t.co/IaVXavjlC7 w/ transcript
2022-12-07 19:37:31 @JReinerMD Thanks Jonathan!
2022-12-07 18:54:30 The last time Covid hospital admissions in New York State was this high was in early February 2022 https://t.co/vw77IAyHJj https://t.co/Zwy5b2byHT
2022-12-07 18:50:25 RT @EricTopol: The body of evidence we have for efficacy and safety of Covid vaccines is the largest in the history of medical interventions
2022-12-07 17:59:57 The rise in US Covid hospitalizations may surpass the summer BA.5 wave, fueled by waning immunity, lack of mitigation and BQ.1.1 https://t.co/o5ibW11jaX https://t.co/Y3Uf6EKC3i
2022-12-07 16:07:37 @JillianHortonMD Thank you!
2022-12-07 15:50:42 The denialism of a new wave extends to the risk of infections and reinfections. "Anyone who doesn’t take seriously the risk of COVID infection is in denial about the risk of #LongCovid and its potentially disabling effects."
2022-12-07 15:40:23 During COVID-19, the US lost more life expectancy than almost any other country as assessed here, #dataviz https://t.co/DIxN3ZrvsK @NatureHumBehav @FortuneMagazine by @Trans_World https://t.co/HSx8SprqVN
2022-12-07 15:27:34 Los Angeles County is the largest county in the US with a population of nearly 10 million people Now with a new Covid surge https://t.co/EM7Ei3cpGB @LukeMMoney @ronlin Cases have doubled and hospitalizations are up 77% in the last 2 weeks https://t.co/2hpenSZ59k https://t.co/xXBiuekLJi
2022-12-07 15:18:44 Much can be done to limit the new Covid wave....that isn't being done. https://t.co/cXxjLDiX3e @latimes my oped @latimesopinion https://t.co/JHQh2odOyG
2022-12-07 14:15:25 The body of evidence we have for efficacy and safety of Covid vaccines is the largest in the history of medical interventions
2022-12-09 04:46:21 @msb1iop @paulg @NatureMedicine @ma_hamer @M_Stamatakis Thanks. I didn't delete anything
2022-12-08 22:03:27 China's elders problem https://t.co/3TcJQYrFul https://t.co/uG4zedUfuK
2022-12-08 21:43:12 Comparison of ChatGPT and AlphaCode https://t.co/QjlEMViyOT
2022-12-08 21:41:13 @richardludlow @NatureMedicine @ma_hamer @M_Stamatakis No cause and effect established or asserted
2022-12-08 19:46:05 RT @hholdenthorp: Enjoyed talking to Tony Fauci about the last few years and what lies ahead. Lots of great stuff in here for science polic…
2022-12-08 19:22:32 No problem, I'll code for you #AlphaCode https://t.co/7m41MgwHUM "This result marks the 1st time an #AI system has performed competitively in programming competitions" @DeepMind @OriolVinyalsML Not so fast. What it can and can't do. https://t.co/lasA1mJK08 by @zicokolter https://t.co/QqRYL14VJh
2022-12-08 18:40:15 Why does having a human cell atlas, with single-cell and spatial definition, have such transformative potential in medicine? https://t.co/l1II0q1was by @jennyErood @AidMaart @teichlab @GraphicAnja Aviv Regev @NatureMedicine https://t.co/0ZSvKnYaMg
2022-12-08 18:29:52 @JeremyKonyndyk Thanks Jeremy!
2022-12-08 17:36:09 1 vs 3 , a 3-fer https://t.co/ik98DuHT76 by @AlexLJanin w/ @dr_kkjetelina https://t.co/jZnusaUtxA @taraparkerpope @FenitN https://t.co/MyRvFSqD2G
2022-12-08 16:51:44 The conclusion is worth reviewing —1 minute bursts, 3 to 4 per day —for non-exercisers, there's hope —these finding only possible via ~25,000 people from @uk_biobank, wearable sensors, and #AI analytics —1st research to measure VILPA effects https://t.co/ECoOUmaaOo
2022-12-08 16:45:19 @paulg @NatureMedicine @ma_hamer @M_Stamatakis Yes, correct. 1 minute bursts made a difference, 3-4 per of these per day associated with the protection
2022-12-08 16:34:59 Vigorous intermittent lifestyle physical activity (VILPA), 3-4 minute bursts per day, associated with ~40% reduction of all-cause mortality, cancer and cardiovascular mortality https://t.co/BoGmigjqWl @NatureMedicine @ma_hamer @M_Stamatakis https://t.co/UPx61oh4Gs
2022-12-08 16:19:41 Subsequent development of #LongCovid detected by gene expression during acute infection. Two different patterns related to antibody production to spike protein https://t.co/ZklAmwyk4L @NatureMedicine @noambeckmann1 @IcahnMountSinai https://t.co/7uklWADq7e
2022-12-08 15:18:00 RT @Yale: PODCAST: @thehowie and @hmkyale are joined by Dr. Eric Topol, a physician and writer to discuss his career turn toward genomics a…